SPAG11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diol metabolic process (GO:0034311)9.88929076
2regulation of translational termination (GO:0006449)9.64003043
3behavioral response to ethanol (GO:0048149)9.52293956
4sphingoid metabolic process (GO:0046519)9.09801986
5regulation of chronic inflammatory response (GO:0002676)8.98033211
6ether lipid metabolic process (GO:0046485)8.97679729
7negative regulation of calcium ion-dependent exocytosis (GO:0045955)8.85598848
8regulation of protein glycosylation (GO:0060049)8.78348070
9adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)8.60446445
10single fertilization (GO:0007338)8.51440631
11adult feeding behavior (GO:0008343)8.47450993
12indole-containing compound catabolic process (GO:0042436)8.43978719
13indolalkylamine catabolic process (GO:0046218)8.43978719
14tryptophan catabolic process (GO:0006569)8.43978719
15heterotypic cell-cell adhesion (GO:0034113)8.40243595
16piRNA metabolic process (GO:0034587)7.69225664
17positive regulation of type 2 immune response (GO:0002830)7.45858467
18negative regulation of interleukin-10 production (GO:0032693)7.26791074
19tryptophan metabolic process (GO:0006568)7.24809576
20regulation of acrosome reaction (GO:0060046)7.16395864
21negative regulation of glycoprotein biosynthetic process (GO:0010561)7.15519058
22notochord development (GO:0030903)6.91155323
23positive regulation of cAMP-mediated signaling (GO:0043950)6.74983721
24negative regulation of nitric oxide biosynthetic process (GO:0045019)6.32777992
25aromatic amino acid family catabolic process (GO:0009074)5.76867458
26fertilization (GO:0009566)5.60084618
27thrombin receptor signaling pathway (GO:0070493)5.46943674
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.44787293
29cellular biogenic amine catabolic process (GO:0042402)5.42511236
30amine catabolic process (GO:0009310)5.42511236
31regulation of glutamate receptor signaling pathway (GO:1900449)5.33498049
32indolalkylamine metabolic process (GO:0006586)5.30721092
33negative regulation of glycoprotein metabolic process (GO:1903019)5.26178015
34negative regulation of interleukin-8 production (GO:0032717)5.11212738
35glycerol ether metabolic process (GO:0006662)4.90239266
36benzene-containing compound metabolic process (GO:0042537)4.84939628
37cellular response to ammonium ion (GO:0071242)4.72584707
38ether metabolic process (GO:0018904)4.68617181
39digestion (GO:0007586)4.56123867
40negative regulation of endopeptidase activity (GO:0010951)4.50859769
41ncRNA catabolic process (GO:0034661)4.46972035
42negative regulation of T cell apoptotic process (GO:0070233)4.39924789
43epithelial cell morphogenesis (GO:0003382)4.33670884
44negative regulation of cell-matrix adhesion (GO:0001953)4.32719677
45signal complex assembly (GO:0007172)4.31718537
46negative regulation of peptidase activity (GO:0010466)4.31088721
47regulation of cAMP-mediated signaling (GO:0043949)4.30984773
48positive regulation of cell-cell adhesion (GO:0022409)4.22612844
49regulation of clathrin-mediated endocytosis (GO:2000369)4.20064043
50aromatic amino acid family metabolic process (GO:0009072)4.18933583
51regulation of female receptivity (GO:0045924)4.10869824
52DNA replication-dependent nucleosome assembly (GO:0006335)4.06697635
53DNA replication-dependent nucleosome organization (GO:0034723)4.06697635
54negative regulation of adenylate cyclase activity (GO:0007194)3.98957267
55cellular response to alkaloid (GO:0071312)3.97071101
56protein-chromophore linkage (GO:0018298)3.89581671
57regulation of type 2 immune response (GO:0002828)3.88240047
58transepithelial transport (GO:0070633)3.87959126
59negative regulation of cyclase activity (GO:0031280)3.79180802
60tachykinin receptor signaling pathway (GO:0007217)3.79100473
61indole-containing compound metabolic process (GO:0042430)3.78447973
62vitamin catabolic process (GO:0009111)3.77048739
63fat-soluble vitamin catabolic process (GO:0042363)3.77048739
64pyrimidine dimer repair (GO:0006290)3.76386797
65sulfur amino acid catabolic process (GO:0000098)3.71928568
66regulation of odontogenesis (GO:0042481)3.70219622
67regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.67768198
68cornea development in camera-type eye (GO:0061303)3.66039508
69reverse cholesterol transport (GO:0043691)3.65060425
70regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.64737616
71membrane depolarization during action potential (GO:0086010)3.62034098
72mRNA cleavage (GO:0006379)3.61907408
73negative regulation of lyase activity (GO:0051350)3.57352105
74defense response to bacterium (GO:0042742)3.56382183
75glomerular visceral epithelial cell development (GO:0072015)3.55672038
76female mating behavior (GO:0060180)3.51887559
77regulation of rhodopsin mediated signaling pathway (GO:0022400)3.50447960
78DNA methylation involved in gamete generation (GO:0043046)3.48479917
79negative regulation of protein autophosphorylation (GO:0031953)3.44040319
80neuronal action potential (GO:0019228)3.38188912
81cell-cell junction maintenance (GO:0045217)3.35346725
82N-acetylneuraminate metabolic process (GO:0006054)3.34892627
83fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.33434828
84regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.33309587
85coenzyme catabolic process (GO:0009109)3.32174711
86spermatid development (GO:0007286)3.28864846
87protein localization to synapse (GO:0035418)3.28754631
88lipopolysaccharide biosynthetic process (GO:0009103)3.25281695
89phospholipid homeostasis (GO:0055091)3.23763074
90regulation of meiosis I (GO:0060631)3.23359446
91rhodopsin mediated signaling pathway (GO:0016056)3.22980925
92regulation of translational elongation (GO:0006448)3.20326557
93alpha-linolenic acid metabolic process (GO:0036109)3.19569446
94response to morphine (GO:0043278)3.19562765
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.14646387
96ribonucleoprotein complex disassembly (GO:0032988)3.12528734
97glycosphingolipid metabolic process (GO:0006687)3.11979558
98left/right axis specification (GO:0070986)3.11818723
99glomerular epithelial cell development (GO:0072310)3.09481046
100response to bacterium (GO:0009617)3.07719277
101dopamine receptor signaling pathway (GO:0007212)3.07276407
102response to isoquinoline alkaloid (GO:0014072)3.05807024
103regulation of lipoprotein metabolic process (GO:0050746)3.03094868
104polyol biosynthetic process (GO:0046173)3.03017157
105positive regulation of cardiac muscle cell differentiation (GO:2000727)3.02629027
106seminiferous tubule development (GO:0072520)24.7639204
107omega-hydroxylase P450 pathway (GO:0097267)2.98246923
108negative regulation of exocytosis (GO:0045920)2.96544220
109sensory perception of pain (GO:0019233)2.96335934
110N-terminal protein amino acid acetylation (GO:0006474)2.94963396
111regulation of macrophage activation (GO:0043030)2.94435702
112complement activation, alternative pathway (GO:0006957)2.94387574
113negative regulation of proteolysis (GO:0045861)2.92436475
114negative regulation of cAMP biosynthetic process (GO:0030818)2.92277856
115thyroid hormone generation (GO:0006590)2.88913102
116synaptic transmission, glutamatergic (GO:0035249)2.88621426
117glomerular basement membrane development (GO:0032836)2.83097192
118positive regulation of fatty acid transport (GO:2000193)2.82047359
119negative regulation of protein maturation (GO:1903318)2.81791757
120negative regulation of protein processing (GO:0010955)2.81791757
121negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.80779239
122membrane lipid metabolic process (GO:0006643)2.79714338
123regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.78289373
124RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77691207
125detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.76683259
126negative regulation of receptor-mediated endocytosis (GO:0048261)2.76166513
127positive regulation of cellular amide metabolic process (GO:0034250)2.75449571
128glycerophospholipid catabolic process (GO:0046475)2.74386747
129positive regulation of icosanoid secretion (GO:0032305)2.74067632
130cysteine metabolic process (GO:0006534)2.73452704
131glial cell proliferation (GO:0014009)2.73366719
132regulation of calcium ion-dependent exocytosis (GO:0017158)2.72909264
133O-glycan processing (GO:0016266)2.72457882
134lipopolysaccharide metabolic process (GO:0008653)2.71091588
135negative regulation of glycogen biosynthetic process (GO:0045719)2.70847830
136negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.68516124
137negative regulation of nucleotide biosynthetic process (GO:0030809)2.68516124
138thyroid hormone metabolic process (GO:0042403)2.67570677
139negative regulation of lymphocyte apoptotic process (GO:0070229)2.67520709
140sialylation (GO:0097503)2.67357091
141smooth muscle tissue development (GO:0048745)2.66556826
142glycolipid metabolic process (GO:0006664)2.66379804
143regulation of activated T cell proliferation (GO:0046006)2.65428195
144positive regulation of nitric oxide biosynthetic process (GO:0045429)2.64723858
145high-density lipoprotein particle remodeling (GO:0034375)2.64636929
146regulation of glycoprotein biosynthetic process (GO:0010559)2.64045765
147regulation of beta-amyloid formation (GO:1902003)2.63900451
148response to caffeine (GO:0031000)2.63731881
149urate metabolic process (GO:0046415)2.62517975
150negative regulation of hydrolase activity (GO:0051346)2.59899421
151regulation of memory T cell differentiation (GO:0043380)2.59235097
152low-density lipoprotein particle clearance (GO:0034383)2.55075508
153positive regulation of interleukin-12 production (GO:0032735)2.52884365
154columnar/cuboidal epithelial cell development (GO:0002066)2.48848639
155hormone catabolic process (GO:0042447)2.48619106
156negative regulation of glycogen metabolic process (GO:0070874)2.43487592
157regulation of endopeptidase activity (GO:0052548)2.42125148
158pyrimidine ribonucleoside catabolic process (GO:0046133)2.41651720
159response to misfolded protein (GO:0051788)2.40087497
160valine metabolic process (GO:0006573)2.39234321
161L-serine transport (GO:0015825)2.38165018
162regulation of amyloid precursor protein catabolic process (GO:1902991)2.35590920
163alpha-amino acid catabolic process (GO:1901606)2.32353146
164lipid catabolic process (GO:0016042)2.31294211
165regulation of peptidase activity (GO:0052547)2.30174626
166negative regulation of interleukin-6 production (GO:0032715)2.29442755
167triglyceride catabolic process (GO:0019433)2.28205528
168cellular amino acid catabolic process (GO:0009063)2.26254494
169regulation of T cell apoptotic process (GO:0070232)2.23814768
170neutral lipid catabolic process (GO:0046461)2.20074025
171acylglycerol catabolic process (GO:0046464)2.20074025
172positive regulation of sterol transport (GO:0032373)2.16711648
173positive regulation of cholesterol transport (GO:0032376)2.16711648
174positive regulation of bone resorption (GO:0045780)2.15663289
175positive regulation of bone remodeling (GO:0046852)2.15663289
176erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.13658383
177L-phenylalanine catabolic process (GO:0006559)2.13658383
178protein-lipid complex remodeling (GO:0034368)2.13192852
179macromolecular complex remodeling (GO:0034367)2.13192852
180plasma lipoprotein particle remodeling (GO:0034369)2.13192852
181regulation of interleukin-10 production (GO:0032653)2.09016588
182serine transport (GO:0032329)2.08259169
183myelin maintenance (GO:0043217)2.08230728
184COPI coating of Golgi vesicle (GO:0048205)2.07679662
185Golgi transport vesicle coating (GO:0048200)2.07679662
186cellular modified amino acid catabolic process (GO:0042219)2.07111048
187regulation of reproductive process (GO:2000241)2.06253149
188ethanol oxidation (GO:0006069)2.04831371
189negative regulation of tumor necrosis factor production (GO:0032720)2.04533774
190production of molecular mediator involved in inflammatory response (GO:0002532)14.1783662
191regulation of T cell tolerance induction (GO:0002664)14.1420440
192negative regulation of cytosolic calcium ion concentration (GO:0051481)14.0920869
193positive regulation of tolerance induction (GO:0002645)12.1443604
194negative regulation of cAMP-mediated signaling (GO:0043951)11.3436934
195sperm capacitation (GO:0048240)11.1271985
196sphingosine metabolic process (GO:0006670)10.9136465
197regulation of tolerance induction (GO:0002643)10.5664998
198kynurenine metabolic process (GO:0070189)10.3883388
199opioid receptor signaling pathway (GO:0038003)10.3676135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.67635779
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.01504677
3IKZF1_21737484_ChIP-ChIP_HCT116_Human3.90894500
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.65696950
5VDR_22108803_ChIP-Seq_LS180_Human3.46406546
6AR_21572438_ChIP-Seq_LNCaP_Human3.27959696
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.08241501
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse3.05856102
9TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.05856102
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.04680501
11EZH2_22144423_ChIP-Seq_EOC_Human2.91125382
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.71529716
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.66330705
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.61265606
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55120818
16GBX2_23144817_ChIP-Seq_PC3_Human2.54282404
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51357349
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.42774304
19RXR_22108803_ChIP-Seq_LS180_Human2.42081210
20ZNF263_19887448_ChIP-Seq_K562_Human2.40210675
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38383359
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.32911488
23RXR_22158963_ChIP-Seq_LIVER_Mouse2.24843004
24LXR_22158963_ChIP-Seq_LIVER_Mouse2.23816499
25TAF15_26573619_Chip-Seq_HEK293_Human2.23282082
26DNAJC2_21179169_ChIP-ChIP_NT2_Human2.13013252
27ZNF274_21170338_ChIP-Seq_K562_Hela2.09995010
28ESR2_21235772_ChIP-Seq_MCF-7_Human2.09530915
29TRIM28_21343339_ChIP-Seq_HEK293_Human2.07292488
30SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.99941448
31EGR1_19032775_ChIP-ChIP_M12_Human1.98939899
32SOX2_19829295_ChIP-Seq_ESCs_Human1.94453379
33NANOG_19829295_ChIP-Seq_ESCs_Human1.94453379
34IGF1R_20145208_ChIP-Seq_DFB_Human1.93381750
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87537506
36CLOCK_20551151_ChIP-Seq_293T_Human1.86645317
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84201285
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83528374
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.83148135
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83028637
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78523382
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.76710575
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74913625
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.74118706
45GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.73954426
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72689649
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70350766
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69591416
49CBP_20019798_ChIP-Seq_JUKART_Human1.67736496
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67736496
51SMAD1_18555785_Chip-Seq_ESCs_Mouse1.64648632
52PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64492586
53TCF4_23295773_ChIP-Seq_U87_Human1.63696644
54NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.61860592
55STAT3_23295773_ChIP-Seq_U87_Human1.57554564
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.56363328
57BCAT_22108803_ChIP-Seq_LS180_Human1.55535683
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55361640
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55361640
60TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.55136854
61SMAD4_21741376_ChIP-Seq_HESCs_Human1.52894445
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51899322
63FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48193013
64REST_19997604_ChIP-ChIP_NEURONS_Mouse1.47935674
65P300_19829295_ChIP-Seq_ESCs_Human1.47914752
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47368482
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.47303873
68FLI1_21867929_ChIP-Seq_CD8_Mouse1.47155665
69SOX2_22085726_ChIP-Seq_NPCs_Mouse1.44235952
70ESRRB_18555785_Chip-Seq_ESCs_Mouse1.41127571
71NANOG_20526341_ChIP-Seq_ESCs_Human1.39948011
72* GATA3_21867929_ChIP-Seq_TH1_Mouse1.38436859
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38354970
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.37612523
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36764066
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35933872
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.33165640
78SMAD3_21741376_ChIP-Seq_HESCs_Human1.33032335
79REST_21632747_ChIP-Seq_MESCs_Mouse1.31449277
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30495615
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30268174
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26630553
83SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.25862879
84AR_25329375_ChIP-Seq_VCAP_Human1.25081087
85CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24579512
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.24357619
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24083315
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.23806180
89ER_23166858_ChIP-Seq_MCF-7_Human1.22815526
90TP53_18474530_ChIP-ChIP_U2OS_Human1.22727532
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22563199
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22413141
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.22213833
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21706023
95* STAT1_17558387_ChIP-Seq_HELA_Human1.21628015
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.19980828
97P68_20966046_ChIP-Seq_HELA_Human1.18656824
98CTCF_18555785_Chip-Seq_ESCs_Mouse1.17715439
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.16775519
100* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16407531
101EZH2_27294783_Chip-Seq_ESCs_Mouse1.15987402
102GATA1_22025678_ChIP-Seq_K562_Human1.15665640
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.15174625
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14626733
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.13606852
106CEBPB_22108803_ChIP-Seq_LS180_Human1.12954178
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12636181
108FUS_26573619_Chip-Seq_HEK293_Human1.12331245
109BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.11800087
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11514743
111JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.11505331
112SMAD4_21799915_ChIP-Seq_A2780_Human1.11502427
113MYC_27129775_Chip-Seq_CORNEA_Mouse1.11471557
114MYC_19915707_ChIP-ChIP_AK7_Human1.10942366
115VDR_24787735_ChIP-Seq_THP-1_Human1.09731752
116RNF2_27304074_Chip-Seq_NSC_Mouse1.09652002
117CBX2_27304074_Chip-Seq_ESCs_Mouse1.09641524
118NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09151823
119TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09119926
120RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09113016
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08895707
122KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08651955
123SMC4_20622854_ChIP-Seq_HELA_Human1.07972766
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.07386134
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06241990
126SOX2_21211035_ChIP-Seq_LN229_Gbm1.06101200
127CRX_20693478_ChIP-Seq_RETINA_Mouse1.05832475
128SALL4_22934838_ChIP-ChIP_CD34+_Human1.05712641
129CDX2_22108803_ChIP-Seq_LS180_Human1.05484452
130RNF2_27304074_Chip-Seq_ESCs_Mouse1.05283247
131SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05106187
132RACK7_27058665_Chip-Seq_MCF-7_Human1.04918597
133MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04490394
134TCF4_22108803_ChIP-Seq_LS180_Human1.04028925
135ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03418788
136TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03328095
137TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03313773
138SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03098193
139UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03076796
140SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02682768
141OCT1_27270436_Chip-Seq_PROSTATE_Human1.02678708
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02678080
143OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02475366
144MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02379205
145SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02173702
146KDM2B_26808549_Chip-Seq_REH_Human1.01910267
147BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01752548
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01455568
149EED_16625203_ChIP-ChIP_MESCs_Mouse1.00801039
150AR_19668381_ChIP-Seq_PC3_Human1.00659708
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99680331
152STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99233287
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99196077
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98683739
155FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97459057
156EZH2_27294783_Chip-Seq_NPCs_Mouse0.96547963
157ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96289124
158SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95583947
159DROSHA_22980978_ChIP-Seq_HELA_Human0.95506698
160REST_18959480_ChIP-ChIP_MESCs_Mouse0.94397829
161EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93879952
162EZH2_27304074_Chip-Seq_ESCs_Mouse0.93419579
163TP53_20018659_ChIP-ChIP_R1E_Mouse0.93296420
164BCL6_27268052_Chip-Seq_Bcells_Human0.92588502
165FOXH1_21741376_ChIP-Seq_ESCs_Human0.92538185
166BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90542968
167SOX2_18555785_Chip-Seq_ESCs_Mouse0.89897153
168SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89831782
169PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88196725
170LXR_22292898_ChIP-Seq_THP-1_Human0.88080229
171ETS1_21867929_ChIP-Seq_TH2_Mouse0.87102823
172SOX2_20726797_ChIP-Seq_SW620_Human0.86651874
173RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85557896
174ERG_21242973_ChIP-ChIP_JURKAT_Human0.85333782
175P300_27268052_Chip-Seq_Bcells_Human0.85288117
176RAC3_21632823_ChIP-Seq_H3396_Human0.83597422
177NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.82971938
178BCOR_27268052_Chip-Seq_Bcells_Human0.82077052
179KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81042626
180HTT_18923047_ChIP-ChIP_STHdh_Human0.80952336
181OCT4_20526341_ChIP-Seq_ESCs_Human0.80874752

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.78839831
2MP0009278_abnormal_bone_marrow5.32484309
3MP0003195_calcinosis5.22418792
4MP0002254_reproductive_system_inflammat4.89755741
5MP0004043_abnormal_pH_regulation4.61628009
6MP0002139_abnormal_hepatobiliary_system4.17541437
7MP0010234_abnormal_vibrissa_follicle3.98273239
8MP0001968_abnormal_touch/_nociception3.83454779
9MP0003045_fibrosis3.76838302
10MP0005058_abnormal_lysosome_morphology3.41751531
11MP0005410_abnormal_fertilization3.37872070
12MP0005503_abnormal_tendon_morphology3.26070621
13MP0003136_yellow_coat_color3.20004888
14MP0003880_abnormal_central_pattern3.18757726
15MP0003329_amyloid_beta_deposits2.83491122
16MP0000678_abnormal_parathyroid_gland2.63891097
17MP0003646_muscle_fatigue2.52481619
18MP0003183_abnormal_peptide_metabolism2.51659146
19MP0003941_abnormal_skin_development2.41623083
20MP0009764_decreased_sensitivity_to2.35140002
21MP0005551_abnormal_eye_electrophysiolog2.22479678
22MP0000681_abnormal_thyroid_gland2.11214981
23MP0000003_abnormal_adipose_tissue2.09842435
24MP0005360_urolithiasis2.09085070
25MP0010329_abnormal_lipoprotein_level2.06419116
26MP0000604_amyloidosis1.97903756
27MP0005646_abnormal_pituitary_gland1.96309725
28MP0003300_gastrointestinal_ulcer1.94410084
29MP0005171_absent_coat_pigmentation1.93556624
30MP0002168_other_aberrant_phenotype1.92151734
31MP0001664_abnormal_digestion1.80788991
32MP0005365_abnormal_bile_salt1.80301206
33MP0009046_muscle_twitch1.70462186
34MP0000749_muscle_degeneration1.68718420
35MP0005397_hematopoietic_system_phenotyp1.68680748
36MP0001545_abnormal_hematopoietic_system1.68680748
37MP0004885_abnormal_endolymph1.68305283
38MP0006035_abnormal_mitochondrial_morpho1.67289231
39MP0003566_abnormal_cell_adhesion1.64047745
40MP0001765_abnormal_ion_homeostasis1.63680213
41MP0001501_abnormal_sleep_pattern1.61247179
42MP0003890_abnormal_embryonic-extraembry1.56881136
43MP0004130_abnormal_muscle_cell1.55692128
44MP0009745_abnormal_behavioral_response1.55269313
45MP0005085_abnormal_gallbladder_physiolo1.54654285
46MP0000569_abnormal_digit_pigmentation1.53700070
47MP0005375_adipose_tissue_phenotype1.53435603
48MP0005645_abnormal_hypothalamus_physiol1.53233426
49MP0003950_abnormal_plasma_membrane1.52622874
50MP0004147_increased_porphyrin_level1.50682173
51MP0001853_heart_inflammation1.44060042
52MP0004270_analgesia1.43212934
53MP0001440_abnormal_grooming_behavior1.42760147
54MP0004145_abnormal_muscle_electrophysio1.42316880
55MP0002837_dystrophic_cardiac_calcinosis1.41416648
56MP0009643_abnormal_urine_homeostasis1.37983793
57MP0000534_abnormal_ureter_morphology1.33707498
58MP0004859_abnormal_synaptic_plasticity1.33403998
59MP0002249_abnormal_larynx_morphology1.32686741
60MP0003690_abnormal_glial_cell1.32183660
61MP0004858_abnormal_nervous_system1.25772238
62MP0004185_abnormal_adipocyte_glucose1.25313330
63MP0005275_abnormal_skin_tensile1.24999552
64MP0005332_abnormal_amino_acid1.23493819
65MP0002118_abnormal_lipid_homeostasis1.20954098
66MP0003638_abnormal_response/metabolism_1.20718830
67MP0003705_abnormal_hypodermis_morpholog1.18572841
68MP0008438_abnormal_cutaneous_collagen1.17527921
69MP0001756_abnormal_urination1.15036551
70MP0005584_abnormal_enzyme/coenzyme_acti1.14539368
71MP0005083_abnormal_biliary_tract1.13454506
72MP0000537_abnormal_urethra_morphology1.12340431
73MP0003191_abnormal_cellular_cholesterol1.12320343
74MP0002089_abnormal_postnatal_growth/wei1.09273523
75MP0002796_impaired_skin_barrier1.08469319
76MP0005636_abnormal_mineral_homeostasis1.08186400
77MP0006276_abnormal_autonomic_nervous1.07521432
78MP0003632_abnormal_nervous_system1.06772987
79MP0009333_abnormal_splenocyte_physiolog1.05226273
80MP0002896_abnormal_bone_mineralization1.04781938
81MP0002009_preneoplasia1.02003638
82MP0005666_abnormal_adipose_tissue1.01256258
83MP0002160_abnormal_reproductive_system0.97594853
84MP0003252_abnormal_bile_duct0.96774284
85MP0003879_abnormal_hair_cell0.96654943
86MP0000230_abnormal_systemic_arterial0.95697070
87MP0003698_abnormal_male_reproductive0.94610317
88MP0003806_abnormal_nucleotide_metabolis0.93823115
89MP0000747_muscle_weakness0.93618040
90MP0002733_abnormal_thermal_nociception0.93565668
91MP0002909_abnormal_adrenal_gland0.92919587
92MP0009780_abnormal_chondrocyte_physiolo0.92519961
93MP0003075_altered_response_to0.90669401
94MP0008875_abnormal_xenobiotic_pharmacok0.89882378
95MP0005195_abnormal_posterior_eye0.89797513
96MP0006072_abnormal_retinal_apoptosis0.86828917
97MP0002136_abnormal_kidney_physiology0.86758367
98MP0000920_abnormal_myelination0.86752699
99MP0002876_abnormal_thyroid_physiology0.86744575
100MP0002572_abnormal_emotion/affect_behav0.82928225
101MP0000015_abnormal_ear_pigmentation0.82632694
102MP0002229_neurodegeneration0.82171904
103MP0002063_abnormal_learning/memory/cond0.81237656
104MP0005623_abnormal_meninges_morphology0.81226484
105MP0003937_abnormal_limbs/digits/tail_de0.80922150
106MP0003567_abnormal_fetal_cardiomyocyte0.80367100
107MP0002557_abnormal_social/conspecific_i0.80122951
108MP0002933_joint_inflammation0.79905402
109MP0003631_nervous_system_phenotype0.79852025
110MP0005389_reproductive_system_phenotype0.78407268
111MP0002064_seizures0.77992417
112MP0009765_abnormal_xenobiotic_induced0.76740405
113MP0005670_abnormal_white_adipose0.75985462
114MP0000609_abnormal_liver_physiology0.75915211
115MP0004036_abnormal_muscle_relaxation0.74926161
116MP0001270_distended_abdomen0.74885254
117MP0004782_abnormal_surfactant_physiolog0.74821472
118MP0008874_decreased_physiological_sensi0.74274395
119MP0001485_abnormal_pinna_reflex0.73362778
120MP0001324_abnormal_eye_pigmentation0.73123664
121MP0003787_abnormal_imprinting0.73117670
122MP0010678_abnormal_skin_adnexa0.72915416
123MP0003635_abnormal_synaptic_transmissio0.72564979
124MP0002067_abnormal_sensory_capabilities0.71818497
125MP0005319_abnormal_enzyme/_coenzyme0.71607865
126MP0002971_abnormal_brown_adipose0.69144793
127MP0003633_abnormal_nervous_system0.68945176
128MP0009384_cardiac_valve_regurgitation0.65807594
129MP0000778_abnormal_nervous_system0.65495852
130MP0001963_abnormal_hearing_physiology0.64958819
131MP0002752_abnormal_somatic_nervous0.64752480
132MP0002735_abnormal_chemical_nociception0.63601507
133MP0005395_other_phenotype0.62699018
134MP0002693_abnormal_pancreas_physiology0.62006041
135MP0005535_abnormal_body_temperature0.61547713
136MP0008775_abnormal_heart_ventricle0.61396011
137MP0000249_abnormal_blood_vessel0.61170037
138MP0005334_abnormal_fat_pad0.61148143
139MP0000538_abnormal_urinary_bladder0.60969383
140MP0008872_abnormal_physiological_respon0.59963385
141MP0004272_abnormal_basement_membrane0.59419885
142MP0005167_abnormal_blood-brain_barrier0.59168313
143MP0002272_abnormal_nervous_system0.59023990
144MP0003634_abnormal_glial_cell0.58236203
145MP0004742_abnormal_vestibular_system0.57241271
146MP0002295_abnormal_pulmonary_circulatio0.56553061
147MP0003959_abnormal_lean_body0.56505243
148MP0002138_abnormal_hepatobiliary_system0.55646034
149MP0001486_abnormal_startle_reflex0.55584850
150MP0000462_abnormal_digestive_system0.55581996
151MP0002095_abnormal_skin_pigmentation0.55489162
152MP0001666_abnormal_nutrient_absorption0.55286460
153MP0001986_abnormal_taste_sensitivity0.55120268
154MP0000751_myopathy0.53875868
155MP0001970_abnormal_pain_threshold0.53702982
156MP0002653_abnormal_ependyma_morphology0.52911886
157MP0005377_hearing/vestibular/ear_phenot0.52286014
158MP0003878_abnormal_ear_physiology0.52286014
159MP0000049_abnormal_middle_ear0.50493396
160MP0004142_abnormal_muscle_tone0.49947843
161MP0004233_abnormal_muscle_weight0.49937813
162MP0002938_white_spotting0.49381163
163MP0002166_altered_tumor_susceptibility0.49118156
164MP0001881_abnormal_mammary_gland0.48952597
165MP0009840_abnormal_foam_cell0.48622750
166MP0010771_integument_phenotype0.48372341
167MP0002161_abnormal_fertility/fecundity0.47722529
168MP0008057_abnormal_DNA_replication0.47390192
169MP0004381_abnormal_hair_follicle0.47124705

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.87262835
2Volvulus (HP:0002580)6.68648649
3Intestinal atresia (HP:0011100)6.23464304
4Broad alveolar ridges (HP:0000187)5.60099047
5Pancreatic islet-cell hyperplasia (HP:0004510)5.45850136
6Abnormality of the aortic arch (HP:0012303)5.39899046
7Myocardial infarction (HP:0001658)5.35672753
8Hypophosphatemic rickets (HP:0004912)5.24307233
9Facial shape deformation (HP:0011334)5.16241506
10Potter facies (HP:0002009)5.16241506
11Vascular calcification (HP:0004934)4.97519489
12Complement deficiency (HP:0004431)4.94941578
13Congenital ichthyosiform erythroderma (HP:0007431)4.85098606
14Large for gestational age (HP:0001520)4.75611000
15Thickened helices (HP:0000391)4.64976128
16Cardiovascular calcification (HP:0011915)4.62240854
17Oligodontia (HP:0000677)4.56250520
18Choroideremia (HP:0001139)4.47790119
19Neurofibrillary tangles (HP:0002185)4.36469938
20Amelogenesis imperfecta (HP:0000705)4.34802966
21Poor head control (HP:0002421)4.22796505
22Mesangial abnormality (HP:0001966)4.21032095
23Cerebral inclusion bodies (HP:0100314)4.16328337
24Gaze-evoked nystagmus (HP:0000640)4.08077689
25Tubular atrophy (HP:0000092)3.99089188
26Malnutrition (HP:0004395)3.78877092
27Dialeptic seizures (HP:0011146)3.62359049
28Abnormality of the pancreatic islet cells (HP:0006476)3.61537204
29Abnormality of endocrine pancreas physiology (HP:0012093)3.61537204
30Type II lissencephaly (HP:0007260)3.58314573
31Abnormality of complement system (HP:0005339)3.56492875
32Focal seizures (HP:0007359)3.53026265
33Recurrent gram-negative bacterial infections (HP:0005420)3.52944229
34Cerebellar dysplasia (HP:0007033)3.48312734
35Infantile muscular hypotonia (HP:0008947)3.42702821
36Neoplasm of the heart (HP:0100544)3.40284889
37Intention tremor (HP:0002080)3.27016092
38Abnormality of the ileum (HP:0001549)3.26533925
39Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22642255
40Rickets (HP:0002748)3.22330155
41Abnormality of the fovea (HP:0000493)3.17763399
42Agitation (HP:0000713)3.16370223
43Large eyes (HP:0001090)3.15283210
44Widely patent fontanelles and sutures (HP:0004492)3.13278371
45Supranuclear gaze palsy (HP:0000605)3.12071224
46Xanthomatosis (HP:0000991)3.04729014
47Gastrointestinal atresia (HP:0002589)3.03210492
48Choreoathetosis (HP:0001266)2.99123267
49Hyperthyroidism (HP:0000836)2.96057346
50Tented upper lip vermilion (HP:0010804)2.89086549
51Deep venous thrombosis (HP:0002625)2.88049199
52Vacuolated lymphocytes (HP:0001922)2.85242624
53Chromsome breakage (HP:0040012)2.84588818
54Progressive inability to walk (HP:0002505)2.82710606
55Hemiplegia (HP:0002301)2.81650535
56Congenital stationary night blindness (HP:0007642)2.77691577
57Neonatal respiratory distress (HP:0002643)2.77233512
58Hypoproteinemia (HP:0003075)2.74425128
59Aplasia/Hypoplasia of the brainstem (HP:0007362)2.73787389
60Hypoplasia of the brainstem (HP:0002365)2.73787389
61Lissencephaly (HP:0001339)2.71019204
62Abnormal rod and cone electroretinograms (HP:0008323)2.70665856
63Abnormality of macular pigmentation (HP:0008002)2.70119664
64Abnormality of the alveolar ridges (HP:0006477)2.68942624
65Polar cataract (HP:0010696)2.68063555
66Nephroblastoma (Wilms tumor) (HP:0002667)2.63001491
67Hypopigmentation of the fundus (HP:0007894)2.61036652
68Ketoacidosis (HP:0001993)2.58918871
69Peripheral hypomyelination (HP:0007182)2.57381546
70Pendular nystagmus (HP:0012043)2.52514250
71Hyperpituitarism (HP:0010514)2.51817273
72Osteomalacia (HP:0002749)2.49945330
73Myositis (HP:0100614)2.48853801
74Embryonal renal neoplasm (HP:0011794)2.48164869
75Broad-based gait (HP:0002136)2.47639619
76Optic nerve hypoplasia (HP:0000609)2.47363004
77Ketosis (HP:0001946)2.40822881
78Ulnar claw (HP:0001178)2.38249296
79Generalized tonic-clonic seizures (HP:0002069)2.35043616
80Bony spicule pigmentary retinopathy (HP:0007737)2.34937858
81Gout (HP:0001997)2.34521900
82Hemorrhage of the eye (HP:0011885)2.34285184
83Hyperglycinuria (HP:0003108)2.33442819
84Increased corneal curvature (HP:0100692)2.33389115
85Keratoconus (HP:0000563)2.33389115
86Intrahepatic cholestasis (HP:0001406)2.30824392
87Abnormality of purine metabolism (HP:0004352)2.30703700
88Difficulty running (HP:0009046)2.30645734
89Skin nodule (HP:0200036)2.28965015
90Testicular atrophy (HP:0000029)2.28671593
91Abnormal hemoglobin (HP:0011902)2.27677964
92Dysdiadochokinesis (HP:0002075)2.25849442
93Orchitis (HP:0100796)2.25448556
94Acanthosis nigricans (HP:0000956)2.24935608
95Severe visual impairment (HP:0001141)2.24215405
96Central scotoma (HP:0000603)2.23318246
97Pancreatic cysts (HP:0001737)2.21118668
98Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16273581
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15807215
100Focal segmental glomerulosclerosis (HP:0000097)2.15610503
101Hyporeflexia of lower limbs (HP:0002600)2.14997874
102Thin bony cortex (HP:0002753)2.12918594
103Abnormality of the vitreous humor (HP:0004327)2.11860066
104Abnormality of secondary sexual hair (HP:0009888)2.11405173
105Abnormality of the axillary hair (HP:0100134)2.11405173
106Ectropion (HP:0000656)2.11393084
107Goiter (HP:0000853)2.09271238
108Dysostosis multiplex (HP:0000943)2.07956845
109Hyperphosphatemia (HP:0002905)2.07379735
110Gait ataxia (HP:0002066)2.06717052
111Impulsivity (HP:0100710)2.05548733
112Parakeratosis (HP:0001036)2.04148044
113Abnormality of glycine metabolism (HP:0010895)2.02740422
114Abnormality of serine family amino acid metabolism (HP:0010894)2.02740422
115Pili torti (HP:0003777)2.02325615
116Poor speech (HP:0002465)2.02010849
117Hyperparathyroidism (HP:0000843)2.01745332
118Spastic diplegia (HP:0001264)2.01075732
119Ileus (HP:0002595)2.01066282
120Thyroid-stimulating hormone excess (HP:0002925)12.9397370
121Epidermoid cyst (HP:0200040)1.99344852
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.99055043
123Hepatoblastoma (HP:0002884)1.96891190
124Hypoplastic iliac wings (HP:0002866)1.96786962
125Decreased circulating renin level (HP:0003351)1.96314320
126Myokymia (HP:0002411)1.96224218
127Non-midline cleft lip (HP:0100335)1.95988272
128Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95224680
129Hypoplasia of the pons (HP:0012110)1.95024331
130Ectopia lentis (HP:0001083)1.94220416
131Tubulointerstitial fibrosis (HP:0005576)1.93643028
132Hypertriglyceridemia (HP:0002155)1.93543029
133Hyperlipoproteinemia (HP:0010980)1.93033211
134Right ventricular cardiomyopathy (HP:0011663)1.91916352
135Attenuation of retinal blood vessels (HP:0007843)1.91387526
136Muscle fiber splitting (HP:0003555)1.90752625
137Scotoma (HP:0000575)1.90521522
138Hyperammonemia (HP:0001987)1.87716943
139Restlessness (HP:0000711)1.86428989
140Long nose (HP:0003189)1.86046835
141Inability to walk (HP:0002540)1.85475268
142Systemic lupus erythematosus (HP:0002725)1.85258900
143Hypophosphatemia (HP:0002148)1.85068646
144Glomerulosclerosis (HP:0000096)1.84460658
145Degeneration of the lateral corticospinal tracts (HP:0002314)1.84191932
146Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.84191932
147Progressive neurologic deterioration (HP:0002344)1.84041366
148Hydroxyprolinuria (HP:0003080)1.83056743
149Abnormality of proline metabolism (HP:0010907)1.83056743
150Hamartoma (HP:0010566)1.82477433
151Hypohidrosis (HP:0000966)1.80482588
152Nonprogressive disorder (HP:0003680)1.80264774
153Atonic seizures (HP:0010819)1.79705496
154Wide cranial sutures (HP:0010537)1.78681090
155Segmental peripheral demyelination/remyelination (HP:0003481)1.78259328
156Pancreatic fibrosis (HP:0100732)1.77074081
157Status epilepticus (HP:0002133)1.75888325
158High anterior hairline (HP:0009890)1.75562090
159Gangrene (HP:0100758)1.74164640
160Oligomenorrhea (HP:0000876)1.74014734
161Lack of skin elasticity (HP:0100679)1.73827514
162Amyloidosis (HP:0011034)1.73653948
163Muscular dystrophy (HP:0003560)1.72365065
164Peritonitis (HP:0002586)1.71806963
165Elevated erythrocyte sedimentation rate (HP:0003565)1.71512107
166Action tremor (HP:0002345)1.71479241
167Striae distensae (HP:0001065)1.71393944
168Prominent nose (HP:0000448)1.71293547
169Abnormality of glycolipid metabolism (HP:0010969)1.70944399
170Abnormality of liposaccharide metabolism (HP:0010968)1.70944399
171Abnormality of glycosphingolipid metabolism (HP:0004343)1.70944399
172Increased connective tissue (HP:0009025)1.70833959
173Difficulty walking (HP:0002355)1.70726224
174Aplastic anemia (HP:0001915)1.70709877
175True hermaphroditism (HP:0010459)1.69678439
176Facial diplegia (HP:0001349)1.69314226
177Psychosis (HP:0000709)1.67438491
178Autoimmune hemolytic anemia (HP:0001890)1.67434913
179Hypoalphalipoproteinemia (HP:0003233)1.67309630
180Abnormality of sulfur amino acid metabolism (HP:0004339)1.66609175
181Loss of speech (HP:0002371)1.66539917
182Hyperglycinemia (HP:0002154)1.66234633
183Increased neuronal autofluorescent lipopigment (HP:0002074)1.65805455
184Abnormality of the renal cortex (HP:0011035)1.65654137
185Abnormality of the periventricular white matter (HP:0002518)1.64947941
186Gastrointestinal dysmotility (HP:0002579)1.64537405
187Increased CSF protein (HP:0002922)1.64517619
188Abnormality of macrophages (HP:0004311)1.63581121
189Late onset (HP:0003584)1.63476322
190Calf muscle hypertrophy (HP:0008981)1.62824793
191Pigmentary retinal degeneration (HP:0001146)1.62507133
192Subcapsular cataract (HP:0000523)1.61234038
193Abnormality of monocarboxylic acid metabolism (HP:0010996)1.60535218
194Gonadotropin excess (HP:0000837)1.59920594
195Urinary glycosaminoglycan excretion (HP:0003541)1.59843525
196Mucopolysacchariduria (HP:0008155)1.59843525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK29.30330356
2PINK13.88320778
3MST43.77404773
4STK38L3.48286368
5ERN13.34179439
6LMTK23.20291356
7IRAK32.88321155
8EPHB12.80123798
9SIK12.65250561
10ADRBK12.61412330
11IRAK12.37315010
12LRRK22.37274076
13ACVR1B2.36260998
14PKN22.33891315
15FGFR22.24570717
16TRIB32.22425888
17FER2.15346084
18TAOK32.13715346
19PDGFRA2.13268128
20PNCK2.09700058
21FGFR41.96833405
22WNK41.95259426
23MUSK1.93458465
24STK391.84304194
25PRKD31.74141408
26BMPR1B1.65775719
27ZAK1.57737641
28TGFBR11.50857460
29MAP3K21.50505924
30DYRK31.47479325
31TNK21.46980574
32PTK61.42744699
33PRKCE1.40064857
34RET1.36412530
35TTN1.33919758
36TYRO31.31859410
37MYLK1.31852871
38STK31.30166467
39MAP2K21.29304016
40EPHA21.26533815
41NTRK31.25117485
42RIPK41.23972107
43PTK2B1.22775409
44STK101.20698672
45PTK21.19715072
46PAK31.18379050
47INSR1.16163540
48NTRK11.15568001
49MELK1.11888240
50MAP2K41.11565071
51CDK191.02591146
52SCYL21.02556531
53PRKCH1.00262134
54NEK20.98825913
55PAK60.98088901
56FRK0.98032336
57GRK70.95785813
58TESK10.95506663
59CLK10.95317296
60GRK10.93647134
61FGFR30.93443856
62KSR20.91441538
63MAP3K70.91000111
64BCKDK0.89743783
65NEK90.89495883
66MAPK110.88878032
67EPHB20.86344273
68MAP3K120.85761563
69DMPK0.84540560
70PAK20.82340746
71CDK50.79553142
72ALK0.77017456
73PLK20.76738141
74CAMK1G0.76352122
75GSK3A0.75037658
76PAK40.74944938
77PRKCI0.74013319
78PRKG20.73743314
79LATS20.72966158
80MAPKAPK50.72904774
81CAMK2A0.72523638
82AKT30.72502836
83PHKG10.71268442
84PHKG20.71268442
85WNK10.70834492
86PRKCG0.70253128
87NTRK20.70207033
88MAP3K60.69256477
89DAPK20.67115001
90ICK0.66167287
91EPHA40.66021725
92JAK20.65782029
93MAP2K10.65161175
94DDR20.64907771
95SIK20.63975900
96SRC0.63974156
97PDK30.62259813
98PDK40.62259813
99FYN0.60339766
100PDGFRB0.60104882
101RIPK10.59744380
102MAP3K130.59023929
103FGFR10.57384577
104ROCK20.57279490
105UHMK10.56623106
106PRKACG0.55778278
107CAMK1D0.53621588
108PRKD10.53524581
109MINK10.53258717
110CSNK1E0.53049509
111PRKCZ0.53023247
112CSNK1A1L0.52370657
113FLT30.51888527
114MET0.51503316
115STK380.51228945
116EGFR0.50773573
117GRK50.49786199
118CDK60.49080925
119ERBB20.47713942
120OXSR10.46705318
121LATS10.46635626
122EEF2K0.46203569
123FES0.45574587
124INSRR0.43417140
125MOS0.43124254
126PRKCQ0.42698747
127JAK10.42507483
128WEE10.42179710
129BMX0.41478366
130PIK3CG0.41339941
131CSK0.41151186
132NLK0.40458601
133PDPK10.39412285
134CASK0.35881931
135TIE10.34951306
136SGK10.33914436
137TAF10.33026684
138PRKCB0.32655046
139TGFBR20.32134237
140BRSK10.30473933
141PRKAA20.29719992
142MAPK10.29566431
143CAMK10.29439981
144MAPK30.29319462
145WNK30.28810021
146AKT10.25943444
147MKNK10.25785100
148PRKACA0.25265515
149RPS6KA30.24919711
150ABL10.24617331
151MST1R0.23173324
152MKNK20.22350994
153MAP4K20.22316046
154BRAF0.22058756
155PRKCA0.21818818
156MARK10.21454025
157EIF2AK30.20993110
158CAMK40.19051775
159MAPK130.18563072
160MAPK150.18094699
161CSNK1A10.16864769
162DYRK1A0.15221240
163TSSK60.14519488
164MARK30.14251894
165GSK3B0.12905096
166CSNK1G20.12842227
167TEC0.10196169
168TXK0.09624695
169CSNK2A20.09090836
170PRKACB0.08932778

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.08001070
2Dorso-ventral axis formation_Homo sapiens_hsa043204.23465433
3Glutathione metabolism_Homo sapiens_hsa004804.23009936
4Phototransduction_Homo sapiens_hsa047444.00177872
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.77861977
6Arachidonic acid metabolism_Homo sapiens_hsa005903.45694229
7Sphingolipid metabolism_Homo sapiens_hsa006003.44360373
8Tryptophan metabolism_Homo sapiens_hsa003803.42814055
9Thyroid hormone synthesis_Homo sapiens_hsa049183.31356041
10African trypanosomiasis_Homo sapiens_hsa051433.26350954
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.21837854
12Morphine addiction_Homo sapiens_hsa050322.87157460
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.66371829
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.53347739
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.45477107
16Taste transduction_Homo sapiens_hsa047422.28008513
17Nicotine addiction_Homo sapiens_hsa050332.15110706
18Sulfur metabolism_Homo sapiens_hsa009202.12940561
19Fatty acid degradation_Homo sapiens_hsa000712.06844224
20Fatty acid metabolism_Homo sapiens_hsa012122.02203625
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96385400
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.88313936
23Arginine biosynthesis_Homo sapiens_hsa002201.79771957
24Ovarian steroidogenesis_Homo sapiens_hsa049131.72291484
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70761365
26PPAR signaling pathway_Homo sapiens_hsa033201.67579756
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.67310169
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59137077
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54721204
30Linoleic acid metabolism_Homo sapiens_hsa005911.51436094
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49327598
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47596357
33Salivary secretion_Homo sapiens_hsa049701.38703330
34Glycerolipid metabolism_Homo sapiens_hsa005611.38571675
35Sulfur relay system_Homo sapiens_hsa041221.38305900
36Fanconi anemia pathway_Homo sapiens_hsa034601.20754645
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17765313
38Propanoate metabolism_Homo sapiens_hsa006401.17090773
39Calcium signaling pathway_Homo sapiens_hsa040201.14889625
40Complement and coagulation cascades_Homo sapiens_hsa046101.11969409
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.11474718
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11276277
43Renin secretion_Homo sapiens_hsa049241.10380587
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09101090
45Pentose phosphate pathway_Homo sapiens_hsa000301.05827458
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02645851
47Lysosome_Homo sapiens_hsa041420.99791943
48Gastric acid secretion_Homo sapiens_hsa049710.99464910
49Butanoate metabolism_Homo sapiens_hsa006500.98608619
50Basal transcription factors_Homo sapiens_hsa030220.93832214
51Bile secretion_Homo sapiens_hsa049760.93563409
52Serotonergic synapse_Homo sapiens_hsa047260.93143212
53beta-Alanine metabolism_Homo sapiens_hsa004100.93084446
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92865926
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91572678
56Fat digestion and absorption_Homo sapiens_hsa049750.89057474
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88712188
58Pyruvate metabolism_Homo sapiens_hsa006200.86938059
59Retinol metabolism_Homo sapiens_hsa008300.86348238
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86256464
61Phenylalanine metabolism_Homo sapiens_hsa003600.84314432
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83047192
63GABAergic synapse_Homo sapiens_hsa047270.82957290
64Starch and sucrose metabolism_Homo sapiens_hsa005000.79918603
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.77230028
66Long-term potentiation_Homo sapiens_hsa047200.74385809
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72743881
68Fatty acid elongation_Homo sapiens_hsa000620.72738698
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72265060
70Estrogen signaling pathway_Homo sapiens_hsa049150.71572554
71Ether lipid metabolism_Homo sapiens_hsa005650.71326991
72Collecting duct acid secretion_Homo sapiens_hsa049660.71115510
73Vibrio cholerae infection_Homo sapiens_hsa051100.70391611
74Circadian entrainment_Homo sapiens_hsa047130.69679954
75Prion diseases_Homo sapiens_hsa050200.67801943
76Mineral absorption_Homo sapiens_hsa049780.65952977
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64330122
78Staphylococcus aureus infection_Homo sapiens_hsa051500.63702098
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62727953
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62692634
81Hedgehog signaling pathway_Homo sapiens_hsa043400.61878106
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.61850605
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61703132
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.61701149
85Fatty acid biosynthesis_Homo sapiens_hsa000610.61047694
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60959811
87Histidine metabolism_Homo sapiens_hsa003400.60507623
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59415890
89Arginine and proline metabolism_Homo sapiens_hsa003300.58982339
90Carbon metabolism_Homo sapiens_hsa012000.58208361
91ABC transporters_Homo sapiens_hsa020100.56880138
92ECM-receptor interaction_Homo sapiens_hsa045120.54345525
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53628109
94Dilated cardiomyopathy_Homo sapiens_hsa054140.52983156
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51850033
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50895663
97Synaptic vesicle cycle_Homo sapiens_hsa047210.50146097
98Folate biosynthesis_Homo sapiens_hsa007900.49418240
99Biosynthesis of amino acids_Homo sapiens_hsa012300.49330924
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.48481989
101Chemical carcinogenesis_Homo sapiens_hsa052040.48010313
102Glutamatergic synapse_Homo sapiens_hsa047240.47808058
103Vitamin B6 metabolism_Homo sapiens_hsa007500.47360973
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46668594
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.46172737
106Metabolic pathways_Homo sapiens_hsa011000.45891095
107One carbon pool by folate_Homo sapiens_hsa006700.45309748
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45095021
109Tyrosine metabolism_Homo sapiens_hsa003500.45007484
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.44803733
111Peroxisome_Homo sapiens_hsa041460.44690176
112Amphetamine addiction_Homo sapiens_hsa050310.43498687
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41671043
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41620621
115Basal cell carcinoma_Homo sapiens_hsa052170.41515110
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39967675
117Long-term depression_Homo sapiens_hsa047300.39885183
118Pancreatic secretion_Homo sapiens_hsa049720.39293385
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.38867170
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37711095
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37274953
122Caffeine metabolism_Homo sapiens_hsa002320.36684320
123Oxytocin signaling pathway_Homo sapiens_hsa049210.36409507
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36374759
125N-Glycan biosynthesis_Homo sapiens_hsa005100.35534390
126Insulin secretion_Homo sapiens_hsa049110.35441473
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35027205
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.33176219
129Glucagon signaling pathway_Homo sapiens_hsa049220.32996629
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32097345
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31218798
132Homologous recombination_Homo sapiens_hsa034400.30747064
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30457875
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30242204
135cAMP signaling pathway_Homo sapiens_hsa040240.30123364
136Olfactory transduction_Homo sapiens_hsa047400.30021782
137GnRH signaling pathway_Homo sapiens_hsa049120.29936868
138Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29697957
139Dopaminergic synapse_Homo sapiens_hsa047280.29521544
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28743351
141Notch signaling pathway_Homo sapiens_hsa043300.28605713
142Cholinergic synapse_Homo sapiens_hsa047250.28450334
143Glioma_Homo sapiens_hsa052140.28295547
144Melanogenesis_Homo sapiens_hsa049160.26027101
145Cardiac muscle contraction_Homo sapiens_hsa042600.25364690
146MicroRNAs in cancer_Homo sapiens_hsa052060.24498622
147Cocaine addiction_Homo sapiens_hsa050300.24127190
148Insulin resistance_Homo sapiens_hsa049310.24046144
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20576481
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18918287
151Legionellosis_Homo sapiens_hsa051340.18375091
152Hippo signaling pathway_Homo sapiens_hsa043900.16731152
153Intestinal immune network for IgA production_Homo sapiens_hsa046720.13048397
154Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12914557

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