SPAG16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.77675174
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.36414864
3multicellular organism reproduction (GO:0032504)9.28651751
4acrosome assembly (GO:0001675)8.84477854
5sperm-egg recognition (GO:0035036)8.83250868
6piRNA metabolic process (GO:0034587)8.53993922
7cell wall macromolecule metabolic process (GO:0044036)8.34339443
8cell wall macromolecule catabolic process (GO:0016998)8.34339443
9plasma membrane fusion (GO:0045026)8.21022623
10acrosome reaction (GO:0007340)8.20382654
11binding of sperm to zona pellucida (GO:0007339)8.06668510
12cell-cell recognition (GO:0009988)7.80688267
13male meiosis (GO:0007140)7.69469516
14spermatid development (GO:0007286)7.46977886
15reproduction (GO:0000003)7.42061653
16ventricular system development (GO:0021591)7.24674021
17single fertilization (GO:0007338)6.74167641
18regulation of cilium movement (GO:0003352)6.70925854
19synaptonemal complex organization (GO:0070193)6.63443077
20axoneme assembly (GO:0035082)6.26978789
21synaptonemal complex assembly (GO:0007130)6.15271476
22DNA methylation involved in gamete generation (GO:0043046)5.95732514
23fertilization (GO:0009566)5.67343152
24male meiosis I (GO:0007141)5.61367891
25intraciliary transport (GO:0042073)5.46739267
26sperm capacitation (GO:0048240)5.34554331
27microtubule depolymerization (GO:0007019)5.17545799
28GTP biosynthetic process (GO:0006183)5.16820104
29protein localization to cilium (GO:0061512)5.16782043
30left/right axis specification (GO:0070986)5.13823658
31* spermatogenesis (GO:0007283)5.09993323
32* male gamete generation (GO:0048232)5.08111053
33negative regulation of inclusion body assembly (GO:0090084)4.97320620
34* gamete generation (GO:0007276)4.75865157
35* cilium organization (GO:0044782)4.63705204
36nucleoside diphosphate phosphorylation (GO:0006165)4.61122015
37chromosome organization involved in meiosis (GO:0070192)4.52355525
38UTP biosynthetic process (GO:0006228)4.47350626
39* cilium assembly (GO:0042384)4.47115886
40meiosis I (GO:0007127)4.45868769
41meiotic cell cycle (GO:0051321)4.36723922
42germ cell development (GO:0007281)4.32868527
43meiotic nuclear division (GO:0007126)4.31188043
44microtubule severing (GO:0051013)4.30373557
45cellular process involved in reproduction in multicellular organism (GO:0022412)4.27774286
46cell recognition (GO:0008037)4.12758527
47regulation of inclusion body assembly (GO:0090083)4.10889529
48calcium ion-dependent exocytosis (GO:0017156)4.10662432
49cilium morphogenesis (GO:0060271)4.07535580
50left/right pattern formation (GO:0060972)4.02686202
51UTP metabolic process (GO:0046051)3.94195837
52* cellular component assembly involved in morphogenesis (GO:0010927)3.92046536
53organic cation transport (GO:0015695)3.87233238
54protein polyglutamylation (GO:0018095)3.86250661
55centriole assembly (GO:0098534)3.83154899
56microtubule-based movement (GO:0007018)3.82584451
57nonmotile primary cilium assembly (GO:0035058)3.75931698
58* multicellular organismal reproductive process (GO:0048609)3.71815271
59regulation of microtubule-based movement (GO:0060632)3.69231366
60regulation of meiosis I (GO:0060631)3.55994387
61guanosine-containing compound biosynthetic process (GO:1901070)3.42513684
62spermatid nucleus differentiation (GO:0007289)3.37530749
63seminiferous tubule development (GO:0072520)3.31600804
64centriole replication (GO:0007099)3.30611465
65CTP metabolic process (GO:0046036)3.28803492
66CTP biosynthetic process (GO:0006241)3.28803492
67monoubiquitinated protein deubiquitination (GO:0035520)3.18084610
68water-soluble vitamin biosynthetic process (GO:0042364)3.10472372
69presynaptic membrane assembly (GO:0097105)3.08785160
70negative regulation of cytosolic calcium ion concentration (GO:0051481)3.08169169
71microtubule bundle formation (GO:0001578)3.07450751
72synapsis (GO:0007129)3.06710720
73response to pheromone (GO:0019236)3.05259901
74cellular ketone body metabolic process (GO:0046950)3.02222459
75meiotic cell cycle process (GO:1903046)3.01869488
76multicellular organismal development (GO:0007275)2.97878542
77pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.96609344
78pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.90393649
79photoreceptor cell maintenance (GO:0045494)2.89809431
80genitalia morphogenesis (GO:0035112)2.89802893
81pyrimidine nucleobase catabolic process (GO:0006208)2.87200767
82behavioral response to nicotine (GO:0035095)2.86416876
83* cell projection assembly (GO:0030031)2.84754617
84protein K11-linked deubiquitination (GO:0035871)2.83895592
85platelet dense granule organization (GO:0060155)2.83384937
86presynaptic membrane organization (GO:0097090)2.83246409
87lactate metabolic process (GO:0006089)2.80619849
88microtubule polymerization or depolymerization (GO:0031109)2.78281357
89retinal ganglion cell axon guidance (GO:0031290)2.70709120
90dendritic spine morphogenesis (GO:0060997)2.68500419
91protein complex biogenesis (GO:0070271)2.67549279
92ketone body metabolic process (GO:1902224)2.64223985
93gene silencing by RNA (GO:0031047)2.62938002
94determination of left/right symmetry (GO:0007368)2.61136921
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60936298
96glycerol ether metabolic process (GO:0006662)2.60808761
97pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.60337368
98C4-dicarboxylate transport (GO:0015740)2.59778483
99regulation of hexokinase activity (GO:1903299)2.59119181
100regulation of glucokinase activity (GO:0033131)2.59119181
101smoothened signaling pathway (GO:0007224)2.57875712
102nucleobase catabolic process (GO:0046113)2.57071791
103* organelle assembly (GO:0070925)2.56772190
104positive regulation of mitochondrial fission (GO:0090141)2.56157754
105nucleotide phosphorylation (GO:0046939)2.54545355
106DNA double-strand break processing (GO:0000729)2.53154821
107detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.51834026
108respiratory chain complex IV assembly (GO:0008535)2.51645985
109determination of bilateral symmetry (GO:0009855)2.50388779
110regulation of acrosome reaction (GO:0060046)2.49575754
111fucose catabolic process (GO:0019317)2.48216151
112L-fucose metabolic process (GO:0042354)2.48216151
113L-fucose catabolic process (GO:0042355)2.48216151
114positive regulation of meiosis (GO:0045836)2.47899706
115pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.47806579
116regulation of spindle checkpoint (GO:0090231)2.47608500
117branched-chain amino acid catabolic process (GO:0009083)2.46628822
118regulation of centriole replication (GO:0046599)2.46396026
119cellular response to gamma radiation (GO:0071480)2.45907992
120retinal cone cell development (GO:0046549)2.45196201
121mitochondrial respiratory chain complex assembly (GO:0033108)2.45003174
122auditory behavior (GO:0031223)2.44988340
123mitochondrial respiratory chain complex I assembly (GO:0032981)2.44814294
124NADH dehydrogenase complex assembly (GO:0010257)2.44814294
125mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.44814294
126calcium ion import (GO:0070509)2.44708934
127specification of symmetry (GO:0009799)2.44637572
128negative regulation of organelle assembly (GO:1902116)2.44014070
129nucleoside diphosphate metabolic process (GO:0009132)2.43380785
130mannosylation (GO:0097502)2.43126382
131neuron fate determination (GO:0048664)2.42614433
132ether metabolic process (GO:0018904)2.41180844
133positive regulation of meiotic cell cycle (GO:0051446)2.40723282
134preassembly of GPI anchor in ER membrane (GO:0016254)2.40154332
135appendage development (GO:0048736)2.39342000
136limb development (GO:0060173)2.39342000
137brain morphogenesis (GO:0048854)2.37626957
138cornea development in camera-type eye (GO:0061303)2.35213040
139regulation of neurotransmitter uptake (GO:0051580)2.34530054
140establishment of protein localization to mitochondrial membrane (GO:0090151)2.32859616
141mechanosensory behavior (GO:0007638)2.32297676
142GPI anchor metabolic process (GO:0006505)2.31344996
143negative regulation of transcription regulatory region DNA binding (GO:2000678)2.30662745
144vascular smooth muscle contraction (GO:0014829)2.30051951
145inositol phosphate catabolic process (GO:0071545)2.29617807
146transmission of nerve impulse (GO:0019226)2.29088871
147aldehyde catabolic process (GO:0046185)2.25671655
148cytochrome complex assembly (GO:0017004)2.24296946
149neural tube formation (GO:0001841)2.24051305
150retinal rod cell development (GO:0046548)2.23716801
151somite development (GO:0061053)2.23563357
152inner ear receptor stereocilium organization (GO:0060122)2.23161686
153histone H2A acetylation (GO:0043968)2.22839144
154photoreceptor cell development (GO:0042461)2.22382427
155gamma-aminobutyric acid transport (GO:0015812)2.19820337
156RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.18970756
157tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.18970756
158postsynaptic membrane organization (GO:0001941)2.18031919
159response to nitrosative stress (GO:0051409)2.17254626
160calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.17003019
161lateral ventricle development (GO:0021670)2.16627815
162axonal fasciculation (GO:0007413)2.16262458
163spinal cord motor neuron differentiation (GO:0021522)2.15796066
164negative regulation of astrocyte differentiation (GO:0048712)2.14168778
165establishment of protein localization to Golgi (GO:0072600)2.13862668
166cilium or flagellum-dependent cell motility (GO:0001539)14.0534327
167axonemal dynein complex assembly (GO:0070286)12.2699876
168cilium movement (GO:0003341)11.2082782
169epithelial cilium movement (GO:0003351)11.1178653
170fusion of sperm to egg plasma membrane (GO:0007342)10.6668407
171sperm motility (GO:0030317)10.0080471

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.43248789
2EZH2_22144423_ChIP-Seq_EOC_Human5.03248792
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.06093368
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.27925216
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.66315445
6* FLI1_27457419_Chip-Seq_LIVER_Mouse2.51735473
7* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.50994435
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45042293
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39058229
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.35552850
11GBX2_23144817_ChIP-Seq_PC3_Human2.35515085
12* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29174061
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24243115
14* CBX2_27304074_Chip-Seq_ESCs_Mouse2.14273390
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13014496
16EWS_26573619_Chip-Seq_HEK293_Human2.11032566
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09804404
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05765179
19VDR_22108803_ChIP-Seq_LS180_Human2.03567412
20* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.96054782
21* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.95962364
22RNF2_27304074_Chip-Seq_NSC_Mouse1.95641554
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.95536225
24* NFE2_27457419_Chip-Seq_LIVER_Mouse1.92523779
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86920579
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83650687
27* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.82450608
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.81462679
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79312835
30TAF15_26573619_Chip-Seq_HEK293_Human1.77941963
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.77233293
32* NANOG_18555785_Chip-Seq_ESCs_Mouse1.69171794
33* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.68987530
34TAL1_26923725_Chip-Seq_HPCs_Mouse1.68434142
35EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.66144267
36* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63489122
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62721737
38* P53_22387025_ChIP-Seq_ESCs_Mouse1.57101234
39* EZH2_27294783_Chip-Seq_NPCs_Mouse1.55313369
40FUS_26573619_Chip-Seq_HEK293_Human1.51818720
41KAP1_22055183_ChIP-Seq_ESCs_Mouse1.50960108
42* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50816652
43KDM2B_26808549_Chip-Seq_REH_Human1.49851853
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.49735829
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.48209664
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47907089
47* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47568781
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47562717
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47562717
50* STAT3_18555785_Chip-Seq_ESCs_Mouse1.47092624
51* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.46577899
52* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46291921
53AR_25329375_ChIP-Seq_VCAP_Human1.46250134
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46082927
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45584918
56ZNF274_21170338_ChIP-Seq_K562_Hela1.45470011
57* OCT4_18555785_Chip-Seq_ESCs_Mouse1.44968946
58* CMYC_18555785_Chip-Seq_ESCs_Mouse1.44839057
59* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.44809666
60* E2F1_18555785_Chip-Seq_ESCs_Mouse1.43090290
61REST_21632747_ChIP-Seq_MESCs_Mouse1.43046243
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42771165
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42699652
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40435902
65* P300_18555785_Chip-Seq_ESCs_Mouse1.38698965
66ELK4_26923725_Chip-Seq_MESODERM_Mouse1.35118470
67ER_23166858_ChIP-Seq_MCF-7_Human1.34923549
68* CRX_20693478_ChIP-Seq_RETINA_Mouse1.34078103
69* SOX2_18555785_Chip-Seq_ESCs_Mouse1.33645517
70CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.33280936
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33074465
72TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.32999656
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32719060
74* P300_19829295_ChIP-Seq_ESCs_Human1.31391373
75STAT1_17558387_ChIP-Seq_HELA_Human1.30995702
76* KLF4_18555785_Chip-Seq_ESCs_Mouse1.30590673
77* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.30210408
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29943434
79CBP_20019798_ChIP-Seq_JUKART_Human1.29943434
80WDR5_24793694_ChIP-Seq_LNCAP_Human1.28828340
81* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28312224
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28136207
83* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.27588233
84* ZFX_18555785_Chip-Seq_ESCs_Mouse1.27037875
85* RUNX2_22187159_ChIP-Seq_PCA_Human1.26866887
86* TCF4_22108803_ChIP-Seq_LS180_Human1.26846218
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26442138
88* NMYC_18555785_Chip-Seq_ESCs_Mouse1.26414126
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26098944
90SOX2_19829295_ChIP-Seq_ESCs_Human1.26042662
91NANOG_19829295_ChIP-Seq_ESCs_Human1.26042662
92* TCF4_23295773_ChIP-Seq_U87_Human1.24033859
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24031967
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24029751
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22867040
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22654084
97* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22355201
98* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20897645
99CTCF_18555785_Chip-Seq_ESCs_Mouse1.20660881
100* PU1_27457419_Chip-Seq_LIVER_Mouse1.19533426
101MYC_18940864_ChIP-ChIP_HL60_Human1.19245002
102TP53_22573176_ChIP-Seq_HFKS_Human1.18700124
103ELK1_19687146_ChIP-ChIP_HELA_Human1.17459422
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16905943
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.14763164
106* SMAD3_21741376_ChIP-Seq_EPCs_Human1.13931603
107* STAT3_23295773_ChIP-Seq_U87_Human1.13723638
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11621884
109EST1_17652178_ChIP-ChIP_JURKAT_Human1.10791643
110* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09052750
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.08689243
112FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08689243
113RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07593435
114GF1_26923725_Chip-Seq_HPCs_Mouse1.06686935
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.06313477
116TBL1_22424771_ChIP-Seq_293T_Human1.05599327
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05181320
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03925359
119IGF1R_20145208_ChIP-Seq_DFB_Human1.03442800
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03172788
121LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03049266
122BCAT_22108803_ChIP-Seq_LS180_Human1.01381616
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00907907
124JUN_21703547_ChIP-Seq_K562_Human1.00677665
125EZH2_27294783_Chip-Seq_ESCs_Mouse1.00670746
126SOX2_21211035_ChIP-Seq_LN229_Gbm0.99760013
127CDX2_22108803_ChIP-Seq_LS180_Human0.99708420
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98645078
129NFYB_21822215_ChIP-Seq_K562_Human0.98445876
130IRF1_19129219_ChIP-ChIP_H3396_Human0.98242306
131SMAD4_21741376_ChIP-Seq_EPCs_Human0.97968200
132SOX9_26525672_Chip-Seq_HEART_Mouse0.97957240
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97164341
134CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95916945
135* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95281460
136CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94914992
137AR_20517297_ChIP-Seq_VCAP_Human0.94758449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive4.62942148
2MP0008877_abnormal_DNA_methylation4.29560613
3* MP0001929_abnormal_gametogenesis4.22385889
4MP0002653_abnormal_ependyma_morphology3.87231118
5MP0001984_abnormal_olfaction3.39359210
6* MP0002210_abnormal_sex_determination3.09825689
7MP0008004_abnormal_stomach_pH2.67769584
8MP0003136_yellow_coat_color2.60191095
9* MP0002161_abnormal_fertility/fecundity2.49287747
10* MP0001145_abnormal_male_reproductive2.43432318
11* MP0000653_abnormal_sex_gland2.25067236
12MP0003122_maternal_imprinting2.13429200
13MP0000566_synostosis2.12980664
14MP0001529_abnormal_vocalization2.08426443
15MP0005646_abnormal_pituitary_gland2.07158484
16MP0005410_abnormal_fertilization10.8340461
17MP0005623_abnormal_meninges_morphology1.95938942
18MP0009046_muscle_twitch1.92283237
19MP0002102_abnormal_ear_morphology1.90427328
20MP0003195_calcinosis1.88416004
21MP0002938_white_spotting1.87059166
22MP0008789_abnormal_olfactory_epithelium1.81833126
23MP0008995_early_reproductive_senescence1.71148830
24MP0002638_abnormal_pupillary_reflex1.69624797
25MP0003646_muscle_fatigue1.67871745
26MP0002160_abnormal_reproductive_system1.66487917
27MP0003121_genomic_imprinting1.64099354
28MP0008058_abnormal_DNA_repair1.56329824
29MP0002909_abnormal_adrenal_gland1.55464142
30MP0003011_delayed_dark_adaptation1.50656320
31MP0005499_abnormal_olfactory_system1.49470555
32MP0005394_taste/olfaction_phenotype1.49470555
33MP0001188_hyperpigmentation1.47884156
34MP0001293_anophthalmia1.47880869
35MP0002837_dystrophic_cardiac_calcinosis1.41028441
36MP0006292_abnormal_olfactory_placode1.38014185
37MP0005551_abnormal_eye_electrophysiolog1.32450201
38MP0003890_abnormal_embryonic-extraembry1.32334836
39MP0008875_abnormal_xenobiotic_pharmacok1.31839253
40MP0004043_abnormal_pH_regulation1.30989784
41MP0004885_abnormal_endolymph1.28271894
42MP0002736_abnormal_nociception_after1.23662025
43MP0002282_abnormal_trachea_morphology1.23515096
44MP0003880_abnormal_central_pattern1.22903791
45MP0003787_abnormal_imprinting1.21630995
46MP0000383_abnormal_hair_follicle1.20838133
47MP0002234_abnormal_pharynx_morphology1.16042596
48MP0001486_abnormal_startle_reflex1.14883525
49MP0000427_abnormal_hair_cycle1.14312252
50MP0001968_abnormal_touch/_nociception1.13806363
51MP0001440_abnormal_grooming_behavior1.13463266
52MP0005084_abnormal_gallbladder_morpholo1.12171814
53MP0005645_abnormal_hypothalamus_physiol1.10636476
54MP0002090_abnormal_vision1.10137377
55MP0000647_abnormal_sebaceous_gland1.09108984
56MP0010386_abnormal_urinary_bladder1.08426680
57MP0002928_abnormal_bile_duct1.06501153
58MP0005647_abnormal_sex_gland1.05352929
59MP0004742_abnormal_vestibular_system1.05126145
60MP0005670_abnormal_white_adipose1.04818194
61MP0001905_abnormal_dopamine_level1.04264462
62MP0002572_abnormal_emotion/affect_behav1.03084028
63MP0005389_reproductive_system_phenotype1.01262606
64MP0002822_catalepsy1.00910180
65MP0002735_abnormal_chemical_nociception1.00305868
66MP0005248_abnormal_Harderian_gland0.98972629
67MP0005195_abnormal_posterior_eye0.98216880
68MP0009745_abnormal_behavioral_response0.97490068
69MP0005377_hearing/vestibular/ear_phenot0.96899612
70MP0003878_abnormal_ear_physiology0.96899612
71MP0002557_abnormal_social/conspecific_i0.96650002
72MP0000778_abnormal_nervous_system0.96509268
73MP0009780_abnormal_chondrocyte_physiolo0.96312555
74MP0005253_abnormal_eye_physiology0.96030126
75MP0002277_abnormal_respiratory_mucosa0.95707376
76MP0010030_abnormal_orbit_morphology0.95416275
77MP0002751_abnormal_autonomic_nervous0.94687971
78MP0003283_abnormal_digestive_organ0.94489533
79MP0005187_abnormal_penis_morphology0.93600791
80MP0000955_abnormal_spinal_cord0.93121306
81MP0003119_abnormal_digestive_system0.92812025
82MP0000372_irregular_coat_pigmentation0.92635210
83MP0010678_abnormal_skin_adnexa0.91384203
84MP0004147_increased_porphyrin_level0.90707707
85MP0004133_heterotaxia0.90551327
86MP0005451_abnormal_body_composition0.89040615
87MP0000516_abnormal_urinary_system0.88545157
88MP0005367_renal/urinary_system_phenotyp0.88545157
89MP0003786_premature_aging0.88004264
90MP0000569_abnormal_digit_pigmentation0.87168884
91MP0001764_abnormal_homeostasis0.87009516
92MP0001970_abnormal_pain_threshold0.86995950
93MP0004859_abnormal_synaptic_plasticity0.85983019
94MP0000026_abnormal_inner_ear0.85889779
95MP0000631_abnormal_neuroendocrine_gland0.83002971
96MP0008057_abnormal_DNA_replication0.82581925
97MP0006276_abnormal_autonomic_nervous0.82507242
98MP0009697_abnormal_copulation0.81997912
99MP0001765_abnormal_ion_homeostasis0.81340840
100MP0001119_abnormal_female_reproductive0.80496511
101MP0001501_abnormal_sleep_pattern0.79829872
102MP0001963_abnormal_hearing_physiology0.79758198
103MP0002272_abnormal_nervous_system0.79558861
104MP0002734_abnormal_mechanical_nocicepti0.78318354
105MP0000049_abnormal_middle_ear0.77228764
106MP0002752_abnormal_somatic_nervous0.76346020
107MP0005379_endocrine/exocrine_gland_phen0.76010436
108MP0001986_abnormal_taste_sensitivity0.75893472
109MP0006072_abnormal_retinal_apoptosis0.75626316
110MP0010094_abnormal_chromosome_stability0.74556163
111MP0002063_abnormal_learning/memory/cond0.74478394
112MP0003635_abnormal_synaptic_transmissio0.73228658
113MP0002067_abnormal_sensory_capabilities0.72179282
114MP0001485_abnormal_pinna_reflex0.71403028
115MP0004019_abnormal_vitamin_homeostasis0.70299914
116MP0004381_abnormal_hair_follicle0.69897968
117MP0001346_abnormal_lacrimal_gland0.67662583
118MP0002249_abnormal_larynx_morphology0.67161311
119MP0003937_abnormal_limbs/digits/tail_de0.65521651
120MP0002152_abnormal_brain_morphology0.63248047
121MP0003941_abnormal_skin_development0.63098905
122MP0002163_abnormal_gland_morphology0.62319853
123MP0003861_abnormal_nervous_system0.62201937
124MP0003699_abnormal_female_reproductive0.62169741
125MP0002184_abnormal_innervation0.61953528
126MP0005391_vision/eye_phenotype0.61455360
127MP0003879_abnormal_hair_cell0.60106227
128MP0002116_abnormal_craniofacial_bone0.59936124
129MP0005409_darkened_coat_color0.58843831
130MP0002064_seizures0.58625076
131MP0002876_abnormal_thyroid_physiology0.57996447
132MP0001502_abnormal_circadian_rhythm0.57736243
133MP0005423_abnormal_somatic_nervous0.57558377
134MP0009250_abnormal_appendicular_skeleto0.56536734
135MP0003718_maternal_effect0.56085808
136MP0002233_abnormal_nose_morphology0.54664215
137MP0002882_abnormal_neuron_morphology0.54263679
138MP0004142_abnormal_muscle_tone0.52647138
139MP0001664_abnormal_digestion0.52514313
140MP0003938_abnormal_ear_development0.50433087
141MP0000015_abnormal_ear_pigmentation0.50419114
142MP0004270_analgesia0.49989589
143MP0002132_abnormal_respiratory_system0.49767475

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.88027009
2Abnormal ciliary motility (HP:0012262)8.41834790
3Abnormal respiratory epithelium morphology (HP:0012253)8.21953654
4Abnormal respiratory motile cilium morphology (HP:0005938)8.21953654
5Rhinitis (HP:0012384)8.16900427
6Chronic bronchitis (HP:0004469)7.37922807
7Nasal polyposis (HP:0100582)4.74132669
8Bronchiectasis (HP:0002110)4.62584918
9Nephronophthisis (HP:0000090)4.56943894
10Infertility (HP:0000789)4.52774558
11Abnormality of the nasal mucosa (HP:0000433)3.80551031
12Bronchitis (HP:0012387)3.77679701
13Tubulointerstitial nephritis (HP:0001970)3.72253887
14Abnormality of the renal medulla (HP:0100957)3.60102374
15Molar tooth sign on MRI (HP:0002419)3.50332777
16Abnormality of midbrain morphology (HP:0002418)3.50332777
17Medial flaring of the eyebrow (HP:0010747)3.38550218
18Recurrent sinusitis (HP:0011108)3.25451509
19Pancreatic fibrosis (HP:0100732)3.17250435
20True hermaphroditism (HP:0010459)3.08939862
21Tubular atrophy (HP:0000092)2.83672398
22Recurrent otitis media (HP:0000403)2.82556823
23Postaxial foot polydactyly (HP:0001830)2.74880499
24Male infertility (HP:0003251)2.61569833
25Pancreatic cysts (HP:0001737)2.57838333
26Congenital hepatic fibrosis (HP:0002612)2.55318318
27Abnormality of the labia minora (HP:0012880)2.54181169
28Gait imbalance (HP:0002141)2.52914177
29Congenital primary aphakia (HP:0007707)2.52561336
30Tubulointerstitial abnormality (HP:0001969)2.51542823
31Median cleft lip (HP:0000161)2.44540114
32Occipital encephalocele (HP:0002085)2.42448381
33Bile duct proliferation (HP:0001408)2.41641589
34Abnormal biliary tract physiology (HP:0012439)2.41641589
35Cystic liver disease (HP:0006706)2.41129307
36Hyperglycinemia (HP:0002154)2.40484496
37Chronic hepatic failure (HP:0100626)2.32255274
38Abnormality of permanent molar morphology (HP:0011071)2.30963431
39Abnormality of the dental root (HP:0006486)2.30963431
40Taurodontia (HP:0000679)2.30963431
41Nephrogenic diabetes insipidus (HP:0009806)2.30845112
42Intestinal atresia (HP:0011100)2.28697032
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.27487057
44Stage 5 chronic kidney disease (HP:0003774)2.25834175
45Acute necrotizing encephalopathy (HP:0006965)2.23504492
46Abnormality of molar (HP:0011077)2.22174172
47Abnormality of molar morphology (HP:0011070)2.22174172
48Fibular hypoplasia (HP:0003038)2.21371111
49Supernumerary spleens (HP:0009799)2.19634166
50Abnormality of the dental pulp (HP:0006479)2.18596263
51Abnormality of dentin (HP:0010299)2.18304822
52Abnormality of the renal cortex (HP:0011035)2.18277081
53Progressive macrocephaly (HP:0004481)2.13119587
54Abnormal spermatogenesis (HP:0008669)2.12972073
55Postaxial hand polydactyly (HP:0001162)2.12509316
56Furrowed tongue (HP:0000221)2.11761238
57Type II lissencephaly (HP:0007260)2.10157803
58Genital tract atresia (HP:0001827)2.06424314
59Chronic sinusitis (HP:0011109)2.05239159
60Anophthalmia (HP:0000528)2.04004752
61Acute encephalopathy (HP:0006846)2.03378299
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6479502
63Dynein arm defect of respiratory motile cilia (HP:0012255)10.5273630
64Absent/shortened dynein arms (HP:0200106)10.5273630
65Vaginal atresia (HP:0000148)1.99002709
66Narrow forehead (HP:0000341)1.98173708
67Facial cleft (HP:0002006)1.97853386
68Methylmalonic acidemia (HP:0002912)1.97325241
69Mitochondrial inheritance (HP:0001427)1.96786654
70Poor coordination (HP:0002370)1.93627522
71Broad foot (HP:0001769)1.90942871
72Hemiparesis (HP:0001269)1.90939974
73Male pseudohermaphroditism (HP:0000037)1.89939300
74Polyphagia (HP:0002591)1.86614442
75Hypothermia (HP:0002045)1.85885434
76Azoospermia (HP:0000027)1.84673156
77Colon cancer (HP:0003003)1.84175613
78Increased CSF lactate (HP:0002490)1.82877216
79Renal dysplasia (HP:0000110)1.82682389
80Renal cortical cysts (HP:0000803)1.82312908
81Abnormal mitochondria in muscle tissue (HP:0008316)1.81733433
82Hepatic necrosis (HP:0002605)1.81062327
83Attenuation of retinal blood vessels (HP:0007843)1.80743614
84Decreased central vision (HP:0007663)1.80682699
85Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80673248
86Preaxial hand polydactyly (HP:0001177)1.80634160
87Aplasia/Hypoplasia of the lens (HP:0008063)1.80271314
88Oculomotor apraxia (HP:0000657)1.79675178
89Hyperglycinuria (HP:0003108)1.79415416
90Abolished electroretinogram (ERG) (HP:0000550)1.78699273
91Large for gestational age (HP:0001520)1.78149828
92Hepatocellular necrosis (HP:0001404)1.77357222
93Abnormal rod and cone electroretinograms (HP:0008323)1.76901184
94Polydipsia (HP:0001959)1.75462954
95Abnormal drinking behavior (HP:0030082)1.75462954
96Abnormality of glycine metabolism (HP:0010895)1.74352110
97Abnormality of serine family amino acid metabolism (HP:0010894)1.74352110
98Gonadotropin excess (HP:0000837)1.74050155
99Specific learning disability (HP:0001328)1.73160723
100Oligodactyly (hands) (HP:0001180)1.73001189
101Progressive cerebellar ataxia (HP:0002073)1.71142926
102Polyuria (HP:0000103)1.69413670
103Prominent nasal bridge (HP:0000426)1.68709456
104Bifid tongue (HP:0010297)1.68534605
105Multicystic kidney dysplasia (HP:0000003)1.68152195
106Abnormality of alanine metabolism (HP:0010916)1.67867695
107Hyperalaninemia (HP:0003348)1.67867695
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67867695
109Aplasia/Hypoplasia of the tibia (HP:0005772)1.67576998
110Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65669817
111Congenital stationary night blindness (HP:0007642)1.64537415
112Anencephaly (HP:0002323)1.63272842
113Aplasia/Hypoplasia of the spleen (HP:0010451)1.62127965
114Hyperinsulinemic hypoglycemia (HP:0000825)1.62033090
115Chorioretinal coloboma (HP:0000567)1.61633616
116Gastrointestinal atresia (HP:0002589)1.60898219
117Decreased testicular size (HP:0008734)1.59429709
118Labial hypoplasia (HP:0000066)1.56738752
119Sclerocornea (HP:0000647)1.55523446
120Dandy-Walker malformation (HP:0001305)1.55175242
121Chromsome breakage (HP:0040012)1.54349223
122Tubulointerstitial fibrosis (HP:0005576)1.54265077
123Aplasia/Hypoplasia of the fibula (HP:0006492)1.50285999
124Abnormality of renal excretion (HP:0011036)1.47857231
125Short thorax (HP:0010306)1.45259429
126Nephropathy (HP:0000112)1.43398579
127Impulsivity (HP:0100710)1.43376047
128Abnormality of macular pigmentation (HP:0008002)1.43014937
129Microglossia (HP:0000171)1.40822113
130Optic nerve hypoplasia (HP:0000609)1.40496771
131Recurrent bronchitis (HP:0002837)1.37517631
132Aganglionic megacolon (HP:0002251)1.34595255
133Dyschromatopsia (HP:0007641)1.34318338
134Retinal dysplasia (HP:0007973)1.33941334
135Abnormality of abdominal situs (HP:0011620)1.33860895
136Abdominal situs inversus (HP:0003363)1.33860895
137Abnormality of the lower motor neuron (HP:0002366)1.32861752
138Astigmatism (HP:0000483)1.28374866
139Bell-shaped thorax (HP:0001591)1.26103637
140Short ribs (HP:0000773)1.25037403
141Atelectasis (HP:0100750)1.24589785
142Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.24100141
143Retinitis pigmentosa (HP:0000510)1.23949780
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.22274890
145Hyperphosphatemia (HP:0002905)1.18883919
146Sloping forehead (HP:0000340)1.18842575
147Nephroblastoma (Wilms tumor) (HP:0002667)1.18266105
148Aplasia/Hypoplasia of the uvula (HP:0010293)1.17867810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.14005881
2PDK37.14005881
3PDK24.43665860
4FRK4.36965699
5CASK3.41955917
6PNCK3.38422254
7MAP4K23.24801602
8MAPK153.06576911
9TESK12.98764145
10PRKD32.79362771
11TRIM282.65580704
12STK392.45604334
13WNK42.16333758
14ICK2.12605774
15BCR2.01303810
16PTK2B1.87589505
17STK38L1.80447098
18FGFR21.70952941
19MST41.61478382
20MUSK1.48292613
21NEK21.46056659
22CSNK1G21.45397789
23CSNK1G11.44664878
24ERBB31.41898017
25GRK11.38132440
26CSNK1G31.35408896
27ACVR1B1.32477079
28CDK31.25555517
29PAK31.24168460
30MARK11.20074503
31STK381.17153037
32BCKDK1.15741340
33TTK1.12982469
34STK31.10065462
35CSNK1A1L1.09285477
36BMPR1B1.07790804
37LATS11.07520385
38WNK11.06999681
39CDC71.05183208
40PRKCE1.04326303
41CHEK21.02875346
42MKNK10.99971443
43MAP2K70.99270566
44PLK40.97607224
45MAP3K120.92632562
46IRAK10.92560561
47NTRK20.91604196
48EPHA40.91334787
49EPHA30.86516061
50MKNK20.82365438
51CDK80.81643870
52SRPK10.80893687
53MAP3K40.79696610
54NTRK30.78361252
55LIMK10.78027889
56EIF2AK30.76422517
57PINK10.75889702
58NUAK10.75712165
59CCNB10.75345692
60TLK10.73898795
61EPHB20.72726044
62MAPK130.70437401
63TNK20.70169884
64NEK60.67854857
65TNIK0.66649708
66LMTK20.66288315
67VRK20.65575172
68FER0.63622563
69MARK20.63164204
70MINK10.63158886
71PRKCG0.62693464
72CAMKK20.59719181
73RPS6KA40.59312399
74PDK10.59188100
75YES10.56318261
76CSNK1A10.56038117
77VRK10.54975833
78DAPK20.54465262
79STK160.54435291
80ADRBK20.53666477
81CAMK2A0.52428847
82UHMK10.51607155
83TGFBR10.50770495
84BRAF0.50488904
85AKT30.50182677
86ATR0.50105587
87CDK120.49277805
88MAP2K60.48262988
89ERBB40.47837566
90MAPKAPK30.47103373
91CDK190.46703055
92ADRBK10.46277013
93NLK0.45736159
94CAMK2D0.45551830
95ATM0.44267696
96TIE10.43869288
97OXSR10.42381461
98WNK30.42070305
99DMPK0.40991262
100RPS6KA50.40449333
101CHEK10.40420405
102DYRK30.40280544
103PLK20.39541802
104STK240.39488053
105ZAK0.39380913
106NEK10.38968610
107CDK90.37373508
108PKN10.36780334
109PASK0.36260100
110PRKG10.36161263
111CAMK10.36012952
112TSSK60.35744415
113PLK10.35351640
114PRKCI0.35059104
115EIF2AK20.33999654
116NME10.33569839
117CAMK2B0.32697233
118PIK3CA0.32619951
119PRKACB0.32466199
120CSNK1D0.32154883
121PRKAA20.31267485
122PRKAA10.29920923
123BMPR20.29748126
124WEE10.29362877
125PRKCQ0.29271470
126SGK20.27778459
127DYRK20.26973330
128CAMK1G0.25419581
129PHKG10.24982511
130PHKG20.24982511
131INSRR0.24837126
132PLK30.23900228
133PRKACA0.22432801
134RPS6KB10.21502741
135CAMK2G0.21017476
136DYRK1A0.19374114
137MAP3K60.19167091
138BRSK20.18976153
139IRAK20.17812066
140MAPKAPK50.17472994
141BRD40.17340014
142SGK4940.17296132
143SGK2230.17296132
144STK110.17008770
145MAP2K40.16681586
146AURKA0.16615345
147CSNK1E0.16267685

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.73627397
2Vitamin B6 metabolism_Homo sapiens_hsa007503.50373683
3Basal transcription factors_Homo sapiens_hsa030223.38030468
4Fanconi anemia pathway_Homo sapiens_hsa034603.21039405
5Olfactory transduction_Homo sapiens_hsa047402.87086777
6Protein export_Homo sapiens_hsa030602.85723377
7Butanoate metabolism_Homo sapiens_hsa006502.62692610
8Fatty acid biosynthesis_Homo sapiens_hsa000612.43518463
9Nicotine addiction_Homo sapiens_hsa050332.43221825
10Oxidative phosphorylation_Homo sapiens_hsa001902.35669746
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.33633195
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30396970
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.18189051
14Linoleic acid metabolism_Homo sapiens_hsa005912.15707459
15Amphetamine addiction_Homo sapiens_hsa050312.13352513
16Pyruvate metabolism_Homo sapiens_hsa006202.11415555
17Huntingtons disease_Homo sapiens_hsa050162.03541015
18Dorso-ventral axis formation_Homo sapiens_hsa043201.95293621
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.93699100
20Glucagon signaling pathway_Homo sapiens_hsa049221.90678089
21Ether lipid metabolism_Homo sapiens_hsa005651.87472022
22Parkinsons disease_Homo sapiens_hsa050121.86317527
23Taste transduction_Homo sapiens_hsa047421.84985247
24Propanoate metabolism_Homo sapiens_hsa006401.77533896
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71843937
26Steroid biosynthesis_Homo sapiens_hsa001001.61019404
27Peroxisome_Homo sapiens_hsa041461.60300059
28Renin secretion_Homo sapiens_hsa049241.56982511
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56867882
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.55947220
31Calcium signaling pathway_Homo sapiens_hsa040201.55921774
32beta-Alanine metabolism_Homo sapiens_hsa004101.54333880
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53381389
34Sphingolipid metabolism_Homo sapiens_hsa006001.49320647
35Purine metabolism_Homo sapiens_hsa002301.47122176
36Fatty acid elongation_Homo sapiens_hsa000621.46793888
37Arachidonic acid metabolism_Homo sapiens_hsa005901.46675696
38Nitrogen metabolism_Homo sapiens_hsa009101.42434067
39Morphine addiction_Homo sapiens_hsa050321.38892314
40Oocyte meiosis_Homo sapiens_hsa041141.38865974
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.38785052
42Insulin secretion_Homo sapiens_hsa049111.36321545
43Glutamatergic synapse_Homo sapiens_hsa047241.36178281
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33247748
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29989544
46Phototransduction_Homo sapiens_hsa047441.29054002
47Circadian entrainment_Homo sapiens_hsa047131.26714377
48Tryptophan metabolism_Homo sapiens_hsa003801.24123102
49Mineral absorption_Homo sapiens_hsa049781.21814196
50Folate biosynthesis_Homo sapiens_hsa007901.21500747
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19041930
52Ovarian steroidogenesis_Homo sapiens_hsa049131.19000361
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18732918
54Alzheimers disease_Homo sapiens_hsa050101.18365494
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18008894
56RNA polymerase_Homo sapiens_hsa030201.16514454
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16495402
58Glycerophospholipid metabolism_Homo sapiens_hsa005641.15491685
59Hedgehog signaling pathway_Homo sapiens_hsa043401.15176043
60ABC transporters_Homo sapiens_hsa020101.09672644
61Glycosaminoglycan degradation_Homo sapiens_hsa005311.09397030
62Glycerolipid metabolism_Homo sapiens_hsa005611.05277162
63cAMP signaling pathway_Homo sapiens_hsa040241.04989755
64Collecting duct acid secretion_Homo sapiens_hsa049661.04895177
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04684180
66Regulation of autophagy_Homo sapiens_hsa041401.03903631
67Fatty acid degradation_Homo sapiens_hsa000711.03734200
68Cocaine addiction_Homo sapiens_hsa050301.02321448
69Homologous recombination_Homo sapiens_hsa034401.01603715
70Fatty acid metabolism_Homo sapiens_hsa012121.00705082
71Salivary secretion_Homo sapiens_hsa049701.00046057
72Gastric acid secretion_Homo sapiens_hsa049710.92305947
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91813067
74Caffeine metabolism_Homo sapiens_hsa002320.91520239
75Long-term potentiation_Homo sapiens_hsa047200.91065539
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88619232
77Cardiac muscle contraction_Homo sapiens_hsa042600.88394184
78Histidine metabolism_Homo sapiens_hsa003400.85140079
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83346492
80Wnt signaling pathway_Homo sapiens_hsa043100.83009317
81Basal cell carcinoma_Homo sapiens_hsa052170.82171581
82Circadian rhythm_Homo sapiens_hsa047100.81060650
83Non-homologous end-joining_Homo sapiens_hsa034500.79658358
84Synaptic vesicle cycle_Homo sapiens_hsa047210.79602727
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79211747
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77436332
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75355788
88One carbon pool by folate_Homo sapiens_hsa006700.74677608
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.73249691
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72793801
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72285750
92Mismatch repair_Homo sapiens_hsa034300.71316890
93Nucleotide excision repair_Homo sapiens_hsa034200.71055030
94Proteasome_Homo sapiens_hsa030500.70127772
95Selenocompound metabolism_Homo sapiens_hsa004500.69784493
96Pentose phosphate pathway_Homo sapiens_hsa000300.69582569
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68727785
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67846880
99Serotonergic synapse_Homo sapiens_hsa047260.67270542
100mRNA surveillance pathway_Homo sapiens_hsa030150.66606952
101Arginine and proline metabolism_Homo sapiens_hsa003300.66121523
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65126446
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64940359
104Dopaminergic synapse_Homo sapiens_hsa047280.64922007
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64840665
106GABAergic synapse_Homo sapiens_hsa047270.63103253
107Estrogen signaling pathway_Homo sapiens_hsa049150.60636835
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60147353
109Retinol metabolism_Homo sapiens_hsa008300.59992387
110PPAR signaling pathway_Homo sapiens_hsa033200.57655415
111Hippo signaling pathway_Homo sapiens_hsa043900.56402446
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55353837
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54648398
114Inositol phosphate metabolism_Homo sapiens_hsa005620.52384507
115RNA degradation_Homo sapiens_hsa030180.51508009
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.51118979
117Tyrosine metabolism_Homo sapiens_hsa003500.49065961
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48650552
119Fat digestion and absorption_Homo sapiens_hsa049750.46785430
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45850278
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45441586
122Pancreatic secretion_Homo sapiens_hsa049720.44578423
123Base excision repair_Homo sapiens_hsa034100.43731399
124Axon guidance_Homo sapiens_hsa043600.43328348
125Cell cycle_Homo sapiens_hsa041100.42599462
126Thyroid hormone synthesis_Homo sapiens_hsa049180.41594078
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39668937
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39247801
129Chemical carcinogenesis_Homo sapiens_hsa052040.38093178
130Oxytocin signaling pathway_Homo sapiens_hsa049210.38066721
131Alcoholism_Homo sapiens_hsa050340.37741278
132Pyrimidine metabolism_Homo sapiens_hsa002400.35944549
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.34294804
134Metabolic pathways_Homo sapiens_hsa011000.34196825
135Melanogenesis_Homo sapiens_hsa049160.33907987
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33643980
137Systemic lupus erythematosus_Homo sapiens_hsa053220.32192626
138RNA transport_Homo sapiens_hsa030130.31374966
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30793418
140Sulfur metabolism_Homo sapiens_hsa009200.30786361
141Glutathione metabolism_Homo sapiens_hsa004800.30569703
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30334708

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