SPAG17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a central pair protein present in the axonemes of cells with a '9 + 2' organization of microtubules. The encoded protein is required for the proper function of the axoneme. Mutations in the orthologous gene in mice lead to primary ciliary dyskinesia characterized by immotile nasal and tracheal cilia, reduced clearance of nasal mucus, profound respiratory distress, hydrocephalus, and neonatal lethality within twelve hours of birth due to impaired airway mucociliary clearance. Single-nucleotide polymorphisms in this gene are associated with human height and targeted mutations lead to skeletal malformations affecting the limbs in mice, suggesting a role for this gene in skeletal development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.88995356
2sperm-egg recognition (GO:0035036)9.70759608
3acrosome assembly (GO:0001675)9.53542384
4acrosome reaction (GO:0007340)9.14838104
5piRNA metabolic process (GO:0034587)9.04705400
6plasma membrane fusion (GO:0045026)8.98829040
7binding of sperm to zona pellucida (GO:0007339)8.90561595
8cell-cell recognition (GO:0009988)8.66014261
9spermatid development (GO:0007286)8.44296150
10regulation of cilium movement (GO:0003352)8.44235475
11reproduction (GO:0000003)8.03331069
12cell wall macromolecule metabolic process (GO:0044036)7.98911695
13cell wall macromolecule catabolic process (GO:0016998)7.98911695
14male meiosis (GO:0007140)7.83071130
15ventricular system development (GO:0021591)7.75172820
16axoneme assembly (GO:0035082)7.29263919
17synaptonemal complex organization (GO:0070193)7.13144690
18single fertilization (GO:0007338)7.02338027
19sperm capacitation (GO:0048240)6.57188528
20synaptonemal complex assembly (GO:0007130)6.52371607
21negative regulation of inclusion body assembly (GO:0090084)6.06377775
22fertilization (GO:0009566)6.01229738
23male meiosis I (GO:0007141)5.99936703
24spermatogenesis (GO:0007283)5.42905877
25male gamete generation (GO:0048232)5.40748311
26DNA methylation involved in gamete generation (GO:0043046)5.35651465
27intraciliary transport (GO:0042073)5.28304932
28primary alcohol catabolic process (GO:0034310)5.15246050
29microtubule severing (GO:0051013)5.06488692
30vitamin transmembrane transport (GO:0035461)5.03920490
31regulation of microtubule-based movement (GO:0060632)5.01989308
32nucleoside diphosphate phosphorylation (GO:0006165)4.99831117
33gamete generation (GO:0007276)4.97928713
34GTP biosynthetic process (GO:0006183)4.91694452
35retinal rod cell development (GO:0046548)4.90129682
36regulation of inclusion body assembly (GO:0090083)4.88113011
37meiosis I (GO:0007127)4.82750080
38germ cell development (GO:0007281)4.80177726
39meiotic cell cycle (GO:0051321)4.70405187
40cellular process involved in reproduction in multicellular organism (GO:0022412)4.70002009
41left/right axis specification (GO:0070986)4.67337653
42protein localization to cilium (GO:0061512)4.66248471
43chromosome organization involved in meiosis (GO:0070192)4.56838177
44left/right pattern formation (GO:0060972)4.55035704
45meiotic nuclear division (GO:0007126)4.54842846
46microtubule-based movement (GO:0007018)4.49687581
47cilium organization (GO:0044782)4.48374066
48ethanol metabolic process (GO:0006067)4.42490020
49organic cation transport (GO:0015695)4.42360485
50diterpenoid biosynthetic process (GO:0016102)4.41159644
51UTP biosynthetic process (GO:0006228)4.37117595
52cilium assembly (GO:0042384)4.21870489
53cell recognition (GO:0008037)4.21689621
54seminiferous tubule development (GO:0072520)4.16542976
55microtubule depolymerization (GO:0007019)4.14785580
56lateral ventricle development (GO:0021670)4.13849407
57response to xenobiotic stimulus (GO:0009410)4.10796637
58regulation of interleukin-5 production (GO:0032674)4.08606488
59calcium ion-dependent exocytosis (GO:0017156)4.04443250
60UTP metabolic process (GO:0046051)3.99465218
61multicellular organismal reproductive process (GO:0048609)3.93123148
62lung epithelium development (GO:0060428)3.91934366
63protein polyglutamylation (GO:0018095)3.91355897
64one-carbon compound transport (GO:0019755)3.90891140
65cellular component assembly involved in morphogenesis (GO:0010927)3.90796118
66microtubule polymerization or depolymerization (GO:0031109)3.90645696
67cilium morphogenesis (GO:0060271)3.90241264
68glomerular epithelial cell development (GO:0072310)3.87524110
69microtubule bundle formation (GO:0001578)3.74584203
70pyrimidine-containing compound transmembrane transport (GO:0072531)3.71828129
71genitalia morphogenesis (GO:0035112)3.70589621
72centriole assembly (GO:0098534)3.68343326
73negative regulation of T cell differentiation in thymus (GO:0033085)3.62275172
74spermatid nucleus differentiation (GO:0007289)3.58749924
75establishment of planar polarity (GO:0001736)3.58080676
76establishment of tissue polarity (GO:0007164)3.58080676
77centriole replication (GO:0007099)3.48154931
78establishment of apical/basal cell polarity (GO:0035089)3.47938877
79regulation of interleukin-13 production (GO:0032656)3.44732356
80negative regulation of humoral immune response (GO:0002921)3.40308160
81protein refolding (GO:0042026)3.39951947
82tolerance induction (GO:0002507)3.38128817
83negative regulation of organelle assembly (GO:1902116)3.37663204
84determination of bilateral symmetry (GO:0009855)3.36191817
85retinal cone cell development (GO:0046549)3.33138421
86monoubiquitinated protein deubiquitination (GO:0035520)3.32498077
87gene silencing by RNA (GO:0031047)3.32294050
88guanosine-containing compound biosynthetic process (GO:1901070)3.31337029
89smoothened signaling pathway (GO:0007224)3.30116418
90regulation of centriole replication (GO:0046599)3.29724830
91negative regulation of B cell mediated immunity (GO:0002713)3.29666238
92negative regulation of immunoglobulin mediated immune response (GO:0002890)3.29666238
93specification of symmetry (GO:0009799)3.28908024
94ethanol oxidation (GO:0006069)3.21709524
95CTP metabolic process (GO:0046036)3.18900019
96CTP biosynthetic process (GO:0006241)3.18900019
97chaperone-mediated protein complex assembly (GO:0051131)3.18078354
98establishment or maintenance of monopolar cell polarity (GO:0061339)3.17731108
99establishment of monopolar cell polarity (GO:0061162)3.17731108
100regulation of protein polyubiquitination (GO:1902914)3.11696672
101cytoplasmic microtubule organization (GO:0031122)3.10510485
102lateral sprouting from an epithelium (GO:0060601)3.10403779
103retinoic acid metabolic process (GO:0042573)3.08895662
104photoreceptor cell maintenance (GO:0045494)3.06756601
105multicellular organismal development (GO:0007275)3.04725270
106positive regulation of smoothened signaling pathway (GO:0045880)3.03731464
107terpenoid biosynthetic process (GO:0016114)2.94594951
108pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.90396619
109regulation of meiosis I (GO:0060631)2.89179475
110meiotic cell cycle process (GO:1903046)2.87165923
111regulation of germinal center formation (GO:0002634)2.86362626
112nonmotile primary cilium assembly (GO:0035058)2.85560286
113glycerol ether metabolic process (GO:0006662)2.82755517
114cell projection assembly (GO:0030031)2.80986443
115alditol metabolic process (GO:0019400)2.80478165
116lactate metabolic process (GO:0006089)2.78885603
117positive regulation of tolerance induction (GO:0002645)2.77784668
118exogenous drug catabolic process (GO:0042738)2.72569465
119regulation of collateral sprouting (GO:0048670)2.71674729
120pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.71327397
121O-glycan processing (GO:0016266)2.70954965
122synapsis (GO:0007129)2.70610425
123carnitine transport (GO:0015879)2.70475033
124amino-acid betaine transport (GO:0015838)2.70475033
125organelle assembly (GO:0070925)2.69160621
126pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.68996230
127carnitine transmembrane transport (GO:1902603)2.68283735
128nucleotide phosphorylation (GO:0046939)2.64859338
129heart looping (GO:0001947)2.64226308
130carnitine metabolic process (GO:0009437)2.61665128
131ether metabolic process (GO:0018904)2.61236187
132peptidyl-glutamic acid modification (GO:0018200)2.61108170
133microtubule-based process (GO:0007017)2.60121123
134negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.56810275
135glutathione derivative biosynthetic process (GO:1901687)2.55116880
136glutathione derivative metabolic process (GO:1901685)2.55116880
137intra-S DNA damage checkpoint (GO:0031573)2.54365208
138limb development (GO:0060173)2.53770124
139appendage development (GO:0048736)2.53770124
140embryonic heart tube morphogenesis (GO:0003143)2.53604369
141nucleoside diphosphate metabolic process (GO:0009132)2.51373535
142glycolytic process (GO:0006096)2.51353863
143determination of left/right symmetry (GO:0007368)2.51197050
144embryonic camera-type eye development (GO:0031076)2.50964123
145retinol metabolic process (GO:0042572)2.48343742
146primary alcohol metabolic process (GO:0034308)2.46170071
147apical protein localization (GO:0045176)2.41912411
148regulation of smoothened signaling pathway (GO:0008589)2.41582423
149phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.41419408
150phosphatidylcholine biosynthetic process (GO:0006656)2.41225466
151spinal cord motor neuron differentiation (GO:0021522)2.36801432
152phosphatidylethanolamine biosynthetic process (GO:0006646)2.36452187
153establishment of nucleus localization (GO:0040023)2.35889680
154excretion (GO:0007588)2.25999713
155cilium or flagellum-dependent cell motility (GO:0001539)18.6779061
156axonemal dynein complex assembly (GO:0070286)14.7264758
157cilium movement (GO:0003341)12.9989321
158epithelial cilium movement (GO:0003351)12.3840917
159fusion of sperm to egg plasma membrane (GO:0007342)11.8056858
160sperm motility (GO:0030317)11.4592281
161motile cilium assembly (GO:0044458)10.8298083
162epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.5813387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.70047605
2EZH2_22144423_ChIP-Seq_EOC_Human5.22068347
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.67340681
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.82460846
5DROSHA_22980978_ChIP-Seq_HELA_Human3.33738262
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.02617260
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.89601298
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.72355724
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50943797
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.37582720
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.37112088
12PIAS1_25552417_ChIP-Seq_VCAP_Human2.27913608
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15859693
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.14093691
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.13597931
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07961397
17AR_21572438_ChIP-Seq_LNCaP_Human2.07098235
18VDR_22108803_ChIP-Seq_LS180_Human1.86445868
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.85588633
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.81646719
21* AHR_22903824_ChIP-Seq_MCF-7_Human1.81508448
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80224165
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79811577
24NR3C1_21868756_ChIP-Seq_MCF10A_Human1.79349129
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77552815
26TOP2B_26459242_ChIP-Seq_MCF-7_Human1.76867533
27* ARNT_22903824_ChIP-Seq_MCF-7_Human1.74543586
28* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73582523
29WDR5_24793694_ChIP-Seq_LNCAP_Human1.71324249
30* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.69294616
31ZNF274_21170338_ChIP-Seq_K562_Hela1.67583287
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64371916
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.64301776
34TP53_18474530_ChIP-ChIP_U2OS_Human1.63492034
35* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.63100765
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60601069
37CBP_20019798_ChIP-Seq_JUKART_Human1.59332546
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59332546
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.57653504
40RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.53418085
41TAL1_26923725_Chip-Seq_HPCs_Mouse1.52002320
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51421321
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.51215686
44ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50076611
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49388535
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.49127322
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.47983716
48* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47869902
49TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.45482429
50* TP63_23658742_ChIP-Seq_EP156T_Human1.45126956
51* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.44448750
52STAT1_17558387_ChIP-Seq_HELA_Human1.43885747
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43527967
54* ETV1_20927104_ChIP-Seq_GIST48_Human1.43270945
55* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43194462
56* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42326343
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40972549
58STAT3_23295773_ChIP-Seq_U87_Human1.40361261
59FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.38411414
60RNF2_27304074_Chip-Seq_NSC_Mouse1.37299040
61MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35414074
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33902773
63GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.33623931
64FUS_26573619_Chip-Seq_HEK293_Human1.33525930
65* HNFA_21074721_ChIP-Seq_CACO-2_Human1.33096154
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32359378
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32123786
68* PHF8_20622853_ChIP-Seq_HELA_Human1.31894075
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31531802
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31531802
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.31223149
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31041344
73* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.30973083
74* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30761446
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.29353817
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28860640
77SOX2_22085726_ChIP-Seq_NPCs_Mouse1.28626873
78KDM2B_26808549_Chip-Seq_REH_Human1.26955969
79REST_21632747_ChIP-Seq_MESCs_Mouse1.25083284
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.24033906
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.23587112
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.22858764
83KLF5_25053715_ChIP-Seq_YYC3_Human1.22120331
84GBX2_23144817_ChIP-Seq_PC3_Human1.21313229
85* NANOG_18555785_Chip-Seq_ESCs_Mouse1.20843365
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.20770205
87TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20527922
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20435445
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.19359081
90* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18625302
91* SMRT_27268052_Chip-Seq_Bcells_Human1.18476283
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18428149
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17354146
94* NFYA_21822215_ChIP-Seq_K562_Human1.16798664
95P53_22387025_ChIP-Seq_ESCs_Mouse1.16442320
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15977586
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15558861
98GF1_26923725_Chip-Seq_HPCs_Mouse1.14132473
99* TCF4_22108803_ChIP-Seq_LS180_Human1.14096401
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13488323
101* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13261847
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13169745
103* RBPJ_21746931_ChIP-Seq_IB4_Human1.13011258
104FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11917787
105LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.11663478
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11515131
107P300_18555785_Chip-Seq_ESCs_Mouse1.10904051
108ESR2_21235772_ChIP-Seq_MCF-7_Human1.10596952
109AR_25329375_ChIP-Seq_VCAP_Human1.09246966
110* RUNX2_22187159_ChIP-Seq_PCA_Human1.09218980
111STAT3_18555785_Chip-Seq_ESCs_Mouse1.09091065
112CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08961200
113EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08008821
114RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08003798
115SMC4_20622854_ChIP-Seq_HELA_Human1.07658586
116P300_19829295_ChIP-Seq_ESCs_Human1.07052778
117TP53_16413492_ChIP-PET_HCT116_Human1.06984552
118KLF4_18555785_Chip-Seq_ESCs_Mouse1.06248419
119FOXA1_25552417_ChIP-Seq_VCAP_Human1.05931108
120GATA3_21867929_ChIP-Seq_CD8_Mouse1.05778112
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.05474395
122SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05418060
123* GATA6_21074721_ChIP-Seq_CACO-2_Human1.04573633
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.04431749
125* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03943873
126* SMAD4_21799915_ChIP-Seq_A2780_Human1.03691986
127* TCF4_23295773_ChIP-Seq_U87_Human1.03625750
128ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03589928
129P53_21459846_ChIP-Seq_SAOS-2_Human1.02914613
130POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02577844
131* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02365147
132ESR1_21235772_ChIP-Seq_MCF-7_Human1.02149725
133* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02037565
134* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01980545
135SMAD3_21741376_ChIP-Seq_HESCs_Human1.01687462
136SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01654440
137EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01580387
138ERG_20517297_ChIP-Seq_VCAP_Human1.01425853
139BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01209879
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01153627
141* SMAD4_21741376_ChIP-Seq_HESCs_Human1.00075984
142SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00014473
143FOXA1_25329375_ChIP-Seq_VCAP_Human0.99844957
144FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99844957
145BCAT_22108803_ChIP-Seq_LS180_Human0.99109786
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99095783
147ER_23166858_ChIP-Seq_MCF-7_Human0.98046497
148GATA3_21867929_ChIP-Seq_TH1_Mouse0.97968549
149RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97814686
150* TP63_22573176_ChIP-Seq_HFKS_Human0.96889806
151E2F1_18555785_Chip-Seq_ESCs_Mouse0.96805100
152PU1_27457419_Chip-Seq_LIVER_Mouse0.96419565
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96379380
154CEBPB_22108803_ChIP-Seq_LS180_Human0.95975599
155CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94750587
156* TBL1_22424771_ChIP-Seq_293T_Human0.94552156
157CDX2_22108803_ChIP-Seq_LS180_Human0.93367045
158AR_19668381_ChIP-Seq_PC3_Human0.93231681
159RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91927281
160* NFYB_21822215_ChIP-Seq_K562_Human0.91822729
161RXR_22108803_ChIP-Seq_LS180_Human0.91748386
162GF1B_26923725_Chip-Seq_HPCs_Mouse0.91441065
163PRDM14_20953172_ChIP-Seq_ESCs_Human0.91384450
164SOX2_18555785_Chip-Seq_ESCs_Mouse0.91038379
165SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90276713
166SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90221619
167TAF15_26573619_Chip-Seq_HEK293_Human0.89654734
168EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89165458
169* ZFX_18555785_Chip-Seq_ESCs_Mouse0.88521098
170SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.88022840
171RUNX1_26923725_Chip-Seq_HPCs_Mouse0.87097439
172SMAD3_21741376_ChIP-Seq_ESCs_Human0.86497842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.85491349
2MP0001929_abnormal_gametogenesis5.30097384
3MP0002653_abnormal_ependyma_morphology4.88121666
4MP0008875_abnormal_xenobiotic_pharmacok4.83117522
5MP0008877_abnormal_DNA_methylation4.27366598
6MP0002210_abnormal_sex_determination3.66254146
7MP0005623_abnormal_meninges_morphology3.57126391
8MP0002277_abnormal_respiratory_mucosa3.36842610
9MP0004043_abnormal_pH_regulation3.17056649
10MP0002161_abnormal_fertility/fecundity3.14455487
11MP0001145_abnormal_male_reproductive3.02906099
12MP0000566_synostosis2.73826435
13MP0000653_abnormal_sex_gland2.65195176
14MP0009780_abnormal_chondrocyte_physiolo2.60565961
15MP0002160_abnormal_reproductive_system2.57862114
16MP0003136_yellow_coat_color2.51070057
17MP0008789_abnormal_olfactory_epithelium2.50972621
18MP0000383_abnormal_hair_follicle2.46765058
19MP0002282_abnormal_trachea_morphology2.11909840
20MP0010678_abnormal_skin_adnexa2.09324240
21MP0005410_abnormal_fertilization14.3185384
22MP0002638_abnormal_pupillary_reflex1.88864647
23MP0001485_abnormal_pinna_reflex1.84371088
24MP0005670_abnormal_white_adipose1.81705357
25MP0008057_abnormal_DNA_replication1.67190412
26MP0005394_taste/olfaction_phenotype1.56176491
27MP0005499_abnormal_olfactory_system1.56176491
28MP0009046_muscle_twitch1.55296212
29MP0005647_abnormal_sex_gland1.46677928
30MP0005083_abnormal_biliary_tract1.39008666
31MP0000026_abnormal_inner_ear1.37862267
32MP0002168_other_aberrant_phenotype1.37492663
33MP0005389_reproductive_system_phenotype1.35361334
34MP0001346_abnormal_lacrimal_gland1.29429424
35MP0003950_abnormal_plasma_membrane1.27371269
36MP0002734_abnormal_mechanical_nocicepti1.26057273
37MP0002233_abnormal_nose_morphology1.24374323
38MP0001984_abnormal_olfaction1.21161529
39MP0002735_abnormal_chemical_nociception1.20889589
40MP0000678_abnormal_parathyroid_gland1.19969883
41MP0002928_abnormal_bile_duct1.19862079
42MP0008995_early_reproductive_senescence1.19711007
43MP0008058_abnormal_DNA_repair1.14356461
44MP0010030_abnormal_orbit_morphology1.13881933
45MP0001765_abnormal_ion_homeostasis1.13047680
46MP0004133_heterotaxia1.07966629
47MP0003656_abnormal_erythrocyte_physiolo1.07150115
48MP0003646_muscle_fatigue1.02827981
49MP0003011_delayed_dark_adaptation1.02185628
50MP0005248_abnormal_Harderian_gland1.01801007
51MP0005395_other_phenotype0.98833475
52MP0001299_abnormal_eye_distance/0.98603225
53MP0001963_abnormal_hearing_physiology0.97376731
54MP0005503_abnormal_tendon_morphology0.95912058
55MP0000955_abnormal_spinal_cord0.94956527
56MP0002909_abnormal_adrenal_gland0.91376026
57MP0000467_abnormal_esophagus_morphology0.90524192
58MP0000049_abnormal_middle_ear0.90191224
59MP0008004_abnormal_stomach_pH0.89820713
60MP0004885_abnormal_endolymph0.89756724
61MP0009379_abnormal_foot_pigmentation0.86048387
62MP0002234_abnormal_pharynx_morphology0.79993614
63MP0005397_hematopoietic_system_phenotyp0.74878341
64MP0001545_abnormal_hematopoietic_system0.74878341
65MP0000631_abnormal_neuroendocrine_gland0.74787794
66MP0010234_abnormal_vibrissa_follicle0.73601266
67MP0001486_abnormal_startle_reflex0.73572924
68MP0005377_hearing/vestibular/ear_phenot0.71343281
69MP0003878_abnormal_ear_physiology0.71343281
70MP0010094_abnormal_chromosome_stability0.70561372
71MP0003938_abnormal_ear_development0.67176430
72MP0001851_eye_inflammation0.67138784
73MP0002876_abnormal_thyroid_physiology0.66387496
74MP0002229_neurodegeneration0.65761062
75MP0001293_anophthalmia0.65063181
76MP0005551_abnormal_eye_electrophysiolog0.64774426
77MP0001502_abnormal_circadian_rhythm0.63987336
78MP0009703_decreased_birth_body0.60870730
79MP0003283_abnormal_digestive_organ0.60573807
80MP0004233_abnormal_muscle_weight0.60397605
81MP0001970_abnormal_pain_threshold0.60167396
82MP0002752_abnormal_somatic_nervous0.59968792
83MP0001286_abnormal_eye_development0.59575805
84MP0003115_abnormal_respiratory_system0.58960078
85MP0009053_abnormal_anal_canal0.56654468
86MP0000358_abnormal_cell_content/0.56565613
87MP0003786_premature_aging0.56472987
88MP0009643_abnormal_urine_homeostasis0.55815472
89MP0002098_abnormal_vibrissa_morphology0.55273660
90MP0004808_abnormal_hematopoietic_stem0.54790300
91MP0004381_abnormal_hair_follicle0.54426501
92MP0005391_vision/eye_phenotype0.54398457
93MP0002133_abnormal_respiratory_system0.54241769
94MP0005388_respiratory_system_phenotype0.54241769
95MP0000762_abnormal_tongue_morphology0.54193138
96MP0002136_abnormal_kidney_physiology0.53330600
97MP0005636_abnormal_mineral_homeostasis0.53085644
98MP0003890_abnormal_embryonic-extraembry0.52616648
99MP0005253_abnormal_eye_physiology0.52387355
100MP0005220_abnormal_exocrine_pancreas0.51879890
101MP0002102_abnormal_ear_morphology0.51461190
102MP0005085_abnormal_gallbladder_physiolo0.51313053
103MP0002882_abnormal_neuron_morphology0.50303432
104MP0002084_abnormal_developmental_patter0.50161942
105MP0001727_abnormal_embryo_implantation0.46921522
106MP0004134_abnormal_chest_morphology0.46527744
107MP0008007_abnormal_cellular_replicative0.45415823
108MP0002092_abnormal_eye_morphology0.44292749
109MP0001324_abnormal_eye_pigmentation0.43297700
110MP0002405_respiratory_system_inflammati0.42444981
111MP0003634_abnormal_glial_cell0.41451902
112MP0001440_abnormal_grooming_behavior0.41391940
113MP0003861_abnormal_nervous_system0.41214757
114MP0004019_abnormal_vitamin_homeostasis0.40453968
115MP0003329_amyloid_beta_deposits0.39938353
116MP0009115_abnormal_fat_cell0.39775751
117MP0003699_abnormal_female_reproductive0.39673276
118MP0003943_abnormal_hepatobiliary_system0.37584390
119MP0002152_abnormal_brain_morphology0.36993357
120MP0005666_abnormal_adipose_tissue0.36162774
121MP0001119_abnormal_female_reproductive0.33894701
122MP0005075_abnormal_melanosome_morpholog0.33719800
123MP0004742_abnormal_vestibular_system0.33642111
124MP0003942_abnormal_urinary_system0.33447102
125MP0005646_abnormal_pituitary_gland0.33335933
126MP0002249_abnormal_larynx_morphology0.32396112
127MP0002971_abnormal_brown_adipose0.30053602
128MP0003633_abnormal_nervous_system0.28553402
129MP0000778_abnormal_nervous_system0.26155617
130MP0000427_abnormal_hair_cycle0.25920329
131MP0006072_abnormal_retinal_apoptosis0.25201087
132MP0002108_abnormal_muscle_morphology0.24603795
133MP0000432_abnormal_head_morphology0.24242598
134MP0002109_abnormal_limb_morphology0.23653938
135MP0005195_abnormal_posterior_eye0.23571704
136MP0002116_abnormal_craniofacial_bone0.23316026
137MP0002132_abnormal_respiratory_system0.22927681
138MP0003045_fibrosis0.22428702
139MP0003937_abnormal_limbs/digits/tail_de0.22299944
140MP0000534_abnormal_ureter_morphology0.21936667
141MP0003879_abnormal_hair_cell0.21321551
142MP0009250_abnormal_appendicular_skeleto0.20220197
143MP0002557_abnormal_social/conspecific_i0.20199044
144MP0001919_abnormal_reproductive_system0.20171205
145MP0002796_impaired_skin_barrier0.20165662
146MP0002295_abnormal_pulmonary_circulatio0.19953544
147MP0001661_extended_life_span0.19669117
148MP0006138_congestive_heart_failure0.19522859
149MP0004811_abnormal_neuron_physiology0.18942594
150MP0002572_abnormal_emotion/affect_behav0.18827610
151MP0000647_abnormal_sebaceous_gland0.18708566
152MP0001270_distended_abdomen0.17582718
153MP0002938_white_spotting0.17385458
154MP0003631_nervous_system_phenotype0.17169563
155MP0002736_abnormal_nociception_after0.17067935

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.53740489
2Abnormal respiratory motile cilium morphology (HP:0005938)9.53740489
3Rhinitis (HP:0012384)9.34527051
4Chronic bronchitis (HP:0004469)7.46312701
5Nasal polyposis (HP:0100582)6.41279304
6Infertility (HP:0000789)5.80859114
7Bronchiectasis (HP:0002110)5.56046876
8Abnormality of the nasal mucosa (HP:0000433)5.26918759
9Bronchitis (HP:0012387)4.48218822
10Nephronophthisis (HP:0000090)4.10165489
11Recurrent sinusitis (HP:0011108)3.72656474
12Male infertility (HP:0003251)3.40002060
13Recurrent otitis media (HP:0000403)3.29073721
14Abnormality of the renal medulla (HP:0100957)3.19226251
15Tubulointerstitial nephritis (HP:0001970)3.13081452
16Chronic otitis media (HP:0000389)2.85814029
17Supernumerary spleens (HP:0009799)2.76060369
18Molar tooth sign on MRI (HP:0002419)2.67400280
19Abnormality of midbrain morphology (HP:0002418)2.67400280
20Pancreatic fibrosis (HP:0100732)2.59217811
21Fibular hypoplasia (HP:0003038)2.57908689
22Medial flaring of the eyebrow (HP:0010747)2.54806865
23Atelectasis (HP:0100750)2.52457477
24True hermaphroditism (HP:0010459)2.49857710
25Hyperactive renin-angiotensin system (HP:0000841)2.49709117
26Recurrent bronchitis (HP:0002837)2.49489569
27Chronic sinusitis (HP:0011109)2.46196274
28Abnormality of the lower motor neuron (HP:0002366)2.45644282
29Postaxial foot polydactyly (HP:0001830)2.45176188
30Congenital hepatic fibrosis (HP:0002612)2.30541402
31Tubular atrophy (HP:0000092)2.25038999
32Tubulointerstitial abnormality (HP:0001969)2.22541210
33Bile duct proliferation (HP:0001408)2.18822152
34Abnormal biliary tract physiology (HP:0012439)2.18822152
35Abnormality of dentin (HP:0010299)2.15452924
36Median cleft lip (HP:0000161)2.12838931
37Cystic liver disease (HP:0006706)2.06388003
38Gonadotropin excess (HP:0000837)2.00365138
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.00287239
40Occipital encephalocele (HP:0002085)2.00260741
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.1165801
42Dynein arm defect of respiratory motile cilia (HP:0012255)11.6136137
43Absent/shortened dynein arms (HP:0200106)11.6136137
44Abnormal respiratory motile cilium physiology (HP:0012261)11.3873978
45Abnormal ciliary motility (HP:0012262)10.1049286
46Amyotrophic lateral sclerosis (HP:0007354)1.95791873
47Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95236259
48Abnormal spermatogenesis (HP:0008669)1.93976792
49Facial cleft (HP:0002006)1.93758676
50Abnormality of permanent molar morphology (HP:0011071)1.91292458
51Abnormality of the dental root (HP:0006486)1.91292458
52Taurodontia (HP:0000679)1.91292458
53Stage 5 chronic kidney disease (HP:0003774)1.87336355
54Abnormality of molar morphology (HP:0011070)1.81782886
55Abnormality of molar (HP:0011077)1.81782886
56Oculomotor apraxia (HP:0000657)1.79901582
57Pancreatic cysts (HP:0001737)1.77730136
58Abnormality of the dental pulp (HP:0006479)1.76848542
59Hyperkalemia (HP:0002153)1.75544226
60Gait imbalance (HP:0002141)1.75152421
61Congenital primary aphakia (HP:0007707)1.75108958
62Abnormal rod and cone electroretinograms (HP:0008323)1.71255967
63Abnormality of the renal cortex (HP:0011035)1.70049169
64Furrowed tongue (HP:0000221)1.68572422
65Decreased circulating renin level (HP:0003351)1.67648997
66Postaxial hand polydactyly (HP:0001162)1.67063674
67Short ribs (HP:0000773)1.62236275
68Microglossia (HP:0000171)1.60990282
69Aplasia/Hypoplasia of the fibula (HP:0006492)1.59532688
70Renal salt wasting (HP:0000127)1.57421393
71Impaired proprioception (HP:0010831)1.56785438
72Impulsivity (HP:0100710)1.56573510
73Renal dysplasia (HP:0000110)1.55751000
74Bell-shaped thorax (HP:0001591)1.54696402
75Asplenia (HP:0001746)1.53347450
76Aplasia/Hypoplasia of the spleen (HP:0010451)1.52379824
77Nephrogenic diabetes insipidus (HP:0009806)1.50785963
78Tubulointerstitial fibrosis (HP:0005576)1.50215058
79Chronic hepatic failure (HP:0100626)1.49845983
80Polydipsia (HP:0001959)1.48853554
81Abnormal drinking behavior (HP:0030082)1.48853554
82Absent frontal sinuses (HP:0002688)1.48689915
83Broad distal phalanx of finger (HP:0009836)1.47473105
84Cone-rod dystrophy (HP:0000548)1.46958346
85Male pseudohermaphroditism (HP:0000037)1.44818330
86Azoospermia (HP:0000027)1.42037185
8711 pairs of ribs (HP:0000878)1.41133300
88Hypoplasia of the capital femoral epiphysis (HP:0003090)1.39936855
89J-shaped sella turcica (HP:0002680)1.39323403
90Genital tract atresia (HP:0001827)1.37088808
91Short thorax (HP:0010306)1.36720206
92Upper motor neuron abnormality (HP:0002127)1.35009386
93Nephropathy (HP:0000112)1.32774544
94Hyperaldosteronism (HP:0000859)1.32675226
95Vaginal atresia (HP:0000148)1.32017326
96Anencephaly (HP:0002323)1.30210733
97Poor coordination (HP:0002370)1.29393480
98Preaxial hand polydactyly (HP:0001177)1.27867840
99Abdominal situs inversus (HP:0003363)1.26700203
100Abnormality of abdominal situs (HP:0011620)1.26700203
101Abnormality of chloride homeostasis (HP:0011422)1.25125190
102Abnormality of renin-angiotensin system (HP:0000847)1.23173437
103Abnormality of renal excretion (HP:0011036)1.23145586
104Aplasia/Hypoplasia of the lens (HP:0008063)1.22756626
105Spastic tetraparesis (HP:0001285)1.20480759
106Dyschromatopsia (HP:0007641)1.19582661
107Bony spicule pigmentary retinopathy (HP:0007737)1.19300699
108Hypokalemic alkalosis (HP:0001949)1.17825354
109Short nail (HP:0001799)1.17165534
110Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.15134965
111Decreased central vision (HP:0007663)1.14439867
112Sclerocornea (HP:0000647)1.12867603
113Bifid scrotum (HP:0000048)1.09544958
114Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.08431708
115Absent epiphyses (HP:0010577)1.08431708
116Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.07783348
117Portal hypertension (HP:0001409)1.07357495
118Retinitis pigmentosa (HP:0000510)1.06751549
119Heterotopia (HP:0002282)1.06540098
120Abnormal gallbladder physiology (HP:0012438)1.06156221
121Abnormality of macular pigmentation (HP:0008002)1.05100590
122Fetal akinesia sequence (HP:0001989)1.03617237
123Abnormality of the frontal sinuses (HP:0002687)1.02931059
124Prominent nasal bridge (HP:0000426)0.99935059
125Aplasia/Hypoplasia involving the sinuses (HP:0009120)0.99244628
126Abnormality of the hepatic vasculature (HP:0006707)0.96474969
127Aganglionic megacolon (HP:0002251)0.96457038
128Multicystic kidney dysplasia (HP:0000003)0.95633511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.32092866
2PDK38.32092866
3PDK25.38200097
4PNCK5.03421274
5TESK14.13923864
6PRKD33.61918954
7EPHA23.27910611
8MAPK153.20125423
9ICK2.86740201
10PTK2B2.51888574
11STK392.49368884
12WNK42.46431050
13MAPKAPK31.82299992
14MAP3K21.72129823
15TSSK61.63277138
16BCR1.59270937
17NEK21.52686405
18NME11.47935646
19WEE11.35108688
20STK241.34807225
21WNK11.32329073
22MST1R1.13112294
23STK381.12881032
24FRK1.02357662
25DYRK30.99642036
26DYRK1B0.98046426
27LATS10.95319580
28TYRO30.92350159
29MAP3K40.92031269
30CAMK1G0.88777664
31MAP3K70.87618048
32INSRR0.87274493
33STK30.87099221
34MAP3K30.86670241
35TRPM70.77758777
36OXSR10.77539211
37IRAK10.76936008
38EPHA30.76886001
39PDK10.76613500
40ERBB20.74340447
41PASK0.70562241
42CDK190.63182232
43GRK10.63111374
44CCNB10.62484100
45TTK0.61921752
46LMTK20.59495618
47ERBB30.57933549
48TLK10.55932654
49CDC70.54415508
50MET0.54398873
51LRRK20.53878827
52PINK10.53812033
53STK160.53307953
54IRAK20.52950408
55PAK20.51077970
56EEF2K0.49152215
57MAPKAPK50.48424462
58NTRK20.45275935
59MAPK130.44641625
60PRKCG0.44351474
61STK100.44110512
62SGK10.43714911
63BMPR1B0.43478454
64PRKCI0.42941402
65MAP2K70.41879222
66CHEK10.41530232
67NTRK30.41255644
68CHEK20.40261656
69PRKAA20.37891852
70EPHB10.37460818
71RIPK40.37215116
72ACVR1B0.36710495
73PLK40.36549710
74STK38L0.36397667
75CDK30.35783664
76ATM0.35016723
77NEK60.33678848
78ATR0.32991063
79MAP4K20.32009149
80MUSK0.31743225
81DDR20.30669293
82SGK2230.29885731
83SGK4940.29885731
84PAK10.29328382
85CAMKK10.28781376
86PRKCD0.28552335
87PBK0.27497934
88ABL10.27301272
89MST40.27045739
90FGFR20.25056231
91BRD40.25051897
92MTOR0.24718756
93NLK0.23745185
94MAP2K60.23050035
95TESK20.23017837
96CDK80.22889252
97ADRBK10.22314405
98DYRK1A0.21970305
99SGK20.21814317
100PRKCE0.20969705
101BRSK20.20689302
102CAMK2G0.20269590
103AURKA0.20186055
104PDPK10.19763217
105ROCK20.19539437
106EPHA40.19376282
107MAP2K40.19138119
108PLK10.18104874
109ADRBK20.17820838
110CASK0.17643897
111RPS6KB10.16255933
112VRK10.15845693
113PRKAA10.15794409
114PRKDC0.12739164
115WNK30.11696040
116PRKCQ0.11083412
117PRKG10.10867576
118GSK3A0.09883853
119MAP2K20.09092600
120PRKACG0.08596214
121CSNK1D0.08188626
122PRKACB0.06700863
123STK110.06589262
124CSNK2A10.06536821
125PKN10.06328384
126TIE10.06249697
127MARK20.06093742
128PRKCZ0.05825532
129CDC42BPA0.05778183
130RPS6KA10.05315573
131CDK120.04893765
132GSK3B0.04522791
133CSNK2A20.03994432
134CDK10.03630803
135RPS6KA30.03486066
136CSK0.03467600
137ROCK10.03289822
138MAPK80.03161987
139RPS6KA20.03093947
140PRKACA0.03017137
141MAPK100.02875732
142CAMK2A0.02361627
143CSNK1E0.02314072
144PAK40.01989200
145MYLK0.01820237
146PRKCB0.01757562
147GRK50.01733486
148PLK20.01020315
149MAPK10.00347259
150SRC0.00138701
151MARK1-0.0087427
152GRK7-0.0084062
153PRKCA-0.0070514
154BRSK1-0.0068823

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.05175666
2Pyruvate metabolism_Homo sapiens_hsa006204.11056869
3Histidine metabolism_Homo sapiens_hsa003404.09457357
4Phenylalanine metabolism_Homo sapiens_hsa003603.94185677
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.77620008
6Dorso-ventral axis formation_Homo sapiens_hsa043203.21769042
7Propanoate metabolism_Homo sapiens_hsa006403.09370077
8Tyrosine metabolism_Homo sapiens_hsa003503.06501538
9Huntingtons disease_Homo sapiens_hsa050162.95726972
10Fatty acid biosynthesis_Homo sapiens_hsa000612.85988144
11beta-Alanine metabolism_Homo sapiens_hsa004102.64273623
12Glucagon signaling pathway_Homo sapiens_hsa049222.57355986
13Fanconi anemia pathway_Homo sapiens_hsa034602.54547662
14Basal transcription factors_Homo sapiens_hsa030222.28860335
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25744539
16Linoleic acid metabolism_Homo sapiens_hsa005912.18970015
17Caffeine metabolism_Homo sapiens_hsa002322.07753996
18PPAR signaling pathway_Homo sapiens_hsa033202.01905188
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.98335515
20Pentose phosphate pathway_Homo sapiens_hsa000301.91039093
21Glycerolipid metabolism_Homo sapiens_hsa005611.88046710
22Oocyte meiosis_Homo sapiens_hsa041141.85348068
23Selenocompound metabolism_Homo sapiens_hsa004501.84403517
24Amphetamine addiction_Homo sapiens_hsa050311.72618220
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.68446804
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65099396
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56732719
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.50709769
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46869640
30Tight junction_Homo sapiens_hsa045301.45535271
31Renin secretion_Homo sapiens_hsa049241.42388298
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34841573
33Notch signaling pathway_Homo sapiens_hsa043301.30425943
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.30387192
35Antigen processing and presentation_Homo sapiens_hsa046121.26461592
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.22538020
37Ether lipid metabolism_Homo sapiens_hsa005651.21723668
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.19717545
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18813085
40Cardiac muscle contraction_Homo sapiens_hsa042601.16392622
41Fructose and mannose metabolism_Homo sapiens_hsa000511.14899936
42Mineral absorption_Homo sapiens_hsa049781.14310628
43Purine metabolism_Homo sapiens_hsa002301.14107764
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.13918406
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11842407
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11660650
47Peroxisome_Homo sapiens_hsa041461.07204799
48Phototransduction_Homo sapiens_hsa047441.06834774
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.06412385
50Carbon metabolism_Homo sapiens_hsa012001.05574295
51mRNA surveillance pathway_Homo sapiens_hsa030151.04964153
52Circadian rhythm_Homo sapiens_hsa047101.04037355
53Hedgehog signaling pathway_Homo sapiens_hsa043401.02787717
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92552336
55ABC transporters_Homo sapiens_hsa020100.90250791
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88827236
57Estrogen signaling pathway_Homo sapiens_hsa049150.87522238
58Nitrogen metabolism_Homo sapiens_hsa009100.86718055
59Starch and sucrose metabolism_Homo sapiens_hsa005000.83881548
60Calcium signaling pathway_Homo sapiens_hsa040200.83829260
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83476909
62Glutathione metabolism_Homo sapiens_hsa004800.82021599
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81152373
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80080351
65Fat digestion and absorption_Homo sapiens_hsa049750.77862505
66Choline metabolism in cancer_Homo sapiens_hsa052310.76307440
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74373198
68Arachidonic acid metabolism_Homo sapiens_hsa005900.74267550
69Adherens junction_Homo sapiens_hsa045200.74108051
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73849183
71RNA transport_Homo sapiens_hsa030130.72929738
72Long-term potentiation_Homo sapiens_hsa047200.71940248
73Butanoate metabolism_Homo sapiens_hsa006500.71809885
74Hippo signaling pathway_Homo sapiens_hsa043900.70886429
75Fatty acid metabolism_Homo sapiens_hsa012120.70642859
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68072987
77Fatty acid degradation_Homo sapiens_hsa000710.67589700
78Chemical carcinogenesis_Homo sapiens_hsa052040.67018855
79Biosynthesis of amino acids_Homo sapiens_hsa012300.61820361
80Taste transduction_Homo sapiens_hsa047420.60913430
81Insulin secretion_Homo sapiens_hsa049110.60500617
82Retinol metabolism_Homo sapiens_hsa008300.58260018
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57927846
84Gastric acid secretion_Homo sapiens_hsa049710.57504566
85Axon guidance_Homo sapiens_hsa043600.57344037
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56456889
87Tryptophan metabolism_Homo sapiens_hsa003800.56360052
88Circadian entrainment_Homo sapiens_hsa047130.54054095
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52827083
90AMPK signaling pathway_Homo sapiens_hsa041520.52557021
91Thyroid hormone synthesis_Homo sapiens_hsa049180.51597010
92Collecting duct acid secretion_Homo sapiens_hsa049660.51203219
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50605409
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48260431
95Inositol phosphate metabolism_Homo sapiens_hsa005620.47259214
96Ovarian steroidogenesis_Homo sapiens_hsa049130.46938356
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45892912
98Olfactory transduction_Homo sapiens_hsa047400.45213322
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44724258
100Serotonergic synapse_Homo sapiens_hsa047260.44709310
101Bile secretion_Homo sapiens_hsa049760.44333253
102cAMP signaling pathway_Homo sapiens_hsa040240.44152533
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44063706
104Basal cell carcinoma_Homo sapiens_hsa052170.43687152
105Sulfur metabolism_Homo sapiens_hsa009200.43463905
106Wnt signaling pathway_Homo sapiens_hsa043100.43331261
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43158313
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42942190
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.42485837
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.42409683
111Cocaine addiction_Homo sapiens_hsa050300.41942513
112Complement and coagulation cascades_Homo sapiens_hsa046100.41869024
113Vitamin digestion and absorption_Homo sapiens_hsa049770.41180952
114Salivary secretion_Homo sapiens_hsa049700.40787977
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.40090623
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39093291
117Metabolic pathways_Homo sapiens_hsa011000.36743853
118Renin-angiotensin system_Homo sapiens_hsa046140.36526122
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.36373971
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35279149
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34960632
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.34713153
123Endocytosis_Homo sapiens_hsa041440.33598428
124Glutamatergic synapse_Homo sapiens_hsa047240.33531520
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33265315
126Melanogenesis_Homo sapiens_hsa049160.32073190
127Protein digestion and absorption_Homo sapiens_hsa049740.31238049
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29892563
129Arginine and proline metabolism_Homo sapiens_hsa003300.29517126
130ECM-receptor interaction_Homo sapiens_hsa045120.29438119
131Systemic lupus erythematosus_Homo sapiens_hsa053220.28456150
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.28349236
133Sphingolipid metabolism_Homo sapiens_hsa006000.27396849
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26974490
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.26666699
136Pyrimidine metabolism_Homo sapiens_hsa002400.26095787
137Dilated cardiomyopathy_Homo sapiens_hsa054140.25898255
138Pancreatic secretion_Homo sapiens_hsa049720.23365895
139Oxytocin signaling pathway_Homo sapiens_hsa049210.23303553
140VEGF signaling pathway_Homo sapiens_hsa043700.20153479
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19939826
142Nicotine addiction_Homo sapiens_hsa050330.19788512
143Synaptic vesicle cycle_Homo sapiens_hsa047210.19300194
144Hepatitis C_Homo sapiens_hsa051600.19218756
145RNA degradation_Homo sapiens_hsa030180.18508446
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15246961
147Hematopoietic cell lineage_Homo sapiens_hsa046400.14679602
148Amoebiasis_Homo sapiens_hsa051460.13896485
149Prostate cancer_Homo sapiens_hsa052150.13204167

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