SPAG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.87556082
2protein localization to chromosome, centromeric region (GO:0071459)5.36189249
3* mitotic sister chromatid segregation (GO:0000070)5.25660872
4* sister chromatid segregation (GO:0000819)5.18815787
5mitotic chromosome condensation (GO:0007076)5.10650196
6kinetochore organization (GO:0051383)5.10624678
7DNA unwinding involved in DNA replication (GO:0006268)4.82190179
8nuclear pore complex assembly (GO:0051292)4.74518300
9nuclear pore organization (GO:0006999)4.70455116
10mitotic metaphase plate congression (GO:0007080)4.69105825
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.49373087
12attachment of spindle microtubules to kinetochore (GO:0008608)4.44918897
13DNA strand elongation involved in DNA replication (GO:0006271)4.44311550
14meiotic chromosome segregation (GO:0045132)4.41404769
15metaphase plate congression (GO:0051310)4.37265493
16microtubule depolymerization (GO:0007019)4.34939873
17establishment of integrated proviral latency (GO:0075713)4.32203399
18DNA replication-dependent nucleosome organization (GO:0034723)4.28853511
19DNA replication-dependent nucleosome assembly (GO:0006335)4.28853511
20DNA replication initiation (GO:0006270)4.26748534
21chromatin remodeling at centromere (GO:0031055)4.25620261
22DNA strand elongation (GO:0022616)4.23584566
23CENP-A containing nucleosome assembly (GO:0034080)4.21733887
24* regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.19905552
25establishment of chromosome localization (GO:0051303)4.16524550
26regulation of spindle organization (GO:0090224)4.16354295
27kinetochore assembly (GO:0051382)4.15736722
28telomere maintenance via semi-conservative replication (GO:0032201)4.15624929
29mitotic nuclear envelope disassembly (GO:0007077)4.14236255
30mitotic sister chromatid cohesion (GO:0007064)4.05524487
31mitotic recombination (GO:0006312)4.00670738
32DNA replication-independent nucleosome organization (GO:0034724)3.98803032
33DNA replication-independent nucleosome assembly (GO:0006336)3.98803032
34regulation of centriole replication (GO:0046599)3.95973658
35telomere maintenance via recombination (GO:0000722)3.92535788
36histone exchange (GO:0043486)3.90521093
37chromosome condensation (GO:0030261)3.87236652
38protein localization to chromosome (GO:0034502)3.84878728
39regulation of histone H3-K9 methylation (GO:0051570)3.84829071
40membrane disassembly (GO:0030397)3.84332634
41nuclear envelope disassembly (GO:0051081)3.84332634
42spindle checkpoint (GO:0031577)3.83290254
43regulation of translational fidelity (GO:0006450)3.81378539
44DNA replication checkpoint (GO:0000076)3.77612710
45* regulation of chromosome segregation (GO:0051983)3.77187855
46positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.77171026
47positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.77171026
48positive regulation of mitotic sister chromatid separation (GO:1901970)3.77171026
49positive regulation of chromosome segregation (GO:0051984)3.73840788
50pore complex assembly (GO:0046931)3.72577555
51* chromosome segregation (GO:0007059)3.71305111
52regulation of centrosome cycle (GO:0046605)3.67605854
53DNA topological change (GO:0006265)3.66027352
54regulation of mitotic spindle organization (GO:0060236)3.65584477
55spindle assembly checkpoint (GO:0071173)3.62208572
56negative regulation of chromosome segregation (GO:0051985)3.61465575
57chromatin assembly or disassembly (GO:0006333)3.60502525
58regulation of sister chromatid cohesion (GO:0007063)3.59471206
59DNA geometric change (GO:0032392)3.59005977
60DNA duplex unwinding (GO:0032508)3.57835020
61protein K6-linked ubiquitination (GO:0085020)3.57757725
62regulation of mitotic metaphase/anaphase transition (GO:0030071)3.57433107
63DNA packaging (GO:0006323)3.56025563
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.55794475
65negative regulation of sister chromatid segregation (GO:0033046)3.55794475
66negative regulation of mitotic sister chromatid separation (GO:2000816)3.55794475
67negative regulation of mitotic sister chromatid segregation (GO:0033048)3.55794475
68double-strand break repair via nonhomologous end joining (GO:0006303)3.53389329
69non-recombinational repair (GO:0000726)3.53389329
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.50114205
71telomere maintenance via telomere lengthening (GO:0010833)3.47736101
72mitotic spindle checkpoint (GO:0071174)3.47481605
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.46371149
74regulation of mitotic sister chromatid separation (GO:0010965)3.45535430
75regulation of mitotic sister chromatid segregation (GO:0033047)3.45535430
76regulation of sister chromatid segregation (GO:0033045)3.45535430
77mitotic spindle assembly checkpoint (GO:0007094)3.45220726
78protein complex localization (GO:0031503)3.45074038
79translesion synthesis (GO:0019985)3.44713778
80DNA conformation change (GO:0071103)3.40333796
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.38902669
82formation of translation preinitiation complex (GO:0001731)3.36843278
83ATP-dependent chromatin remodeling (GO:0043044)3.36291321
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.34710900
85regulation of DNA endoreduplication (GO:0032875)3.30623209
86establishment of viral latency (GO:0019043)3.28297216
87negative regulation of histone methylation (GO:0031061)3.21212514
88chromatin assembly (GO:0031497)3.14328910
89heterochromatin organization (GO:0070828)3.11921116
90regulation of centrosome duplication (GO:0010824)3.11851366
91DNA synthesis involved in DNA repair (GO:0000731)3.10705215
92regulation of nuclear cell cycle DNA replication (GO:0033262)3.08786726
93purine nucleobase biosynthetic process (GO:0009113)3.06585636
94negative regulation of mitosis (GO:0045839)3.04712468
95IMP biosynthetic process (GO:0006188)3.04229974
96telomere maintenance (GO:0000723)3.02236126
97postreplication repair (GO:0006301)3.01274199
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01061549
99nucleobase biosynthetic process (GO:0046112)3.00805965
100mitotic cell cycle (GO:0000278)3.00779566
101negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00769154
102monoubiquitinated protein deubiquitination (GO:0035520)3.00597445
103dosage compensation (GO:0007549)2.99470602
104* chromosome organization (GO:0051276)2.99009951
105telomere organization (GO:0032200)2.98904384
106ribosome assembly (GO:0042255)2.98553131
107negative regulation of DNA-dependent DNA replication (GO:2000104)2.96674837
108DNA ligation (GO:0006266)2.96330519
109mismatch repair (GO:0006298)2.94817521
110mitotic cytokinesis (GO:0000281)2.94237911
111nuclear envelope organization (GO:0006998)2.93923402
112cellular protein complex localization (GO:0034629)2.93209892
113regulation of telomere maintenance via telomerase (GO:0032210)2.92373850
114regulation of RNA export from nucleus (GO:0046831)2.91925876
115DNA strand renaturation (GO:0000733)2.91824461
116folic acid-containing compound biosynthetic process (GO:0009396)2.91144110
117spindle assembly involved in mitosis (GO:0090307)2.90204192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human7.42656355
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human5.04032253
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.44247833
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.83985579
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.33300630
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74173443
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.70528339
8AR_21909140_ChIP-Seq_LNCAP_Human2.65176326
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.51363464
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47575508
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.43285067
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37265971
13MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26881173
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09494103
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07326702
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05225225
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.00489647
18E2F7_22180533_ChIP-Seq_HELA_Human11.2029271
19XRN2_22483619_ChIP-Seq_HELA_Human1.95381087
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91191540
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78826110
22* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77923240
23MYC_22102868_ChIP-Seq_BL_Human1.72203612
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72090543
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.71750449
26CIITA_25753668_ChIP-Seq_RAJI_Human1.71505583
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70253889
28* VDR_23849224_ChIP-Seq_CD4+_Human1.65575863
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.61700323
30FOXP3_21729870_ChIP-Seq_TREG_Human1.61271249
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61068285
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55581071
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54312913
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53399386
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52445263
36TTF2_22483619_ChIP-Seq_HELA_Human1.51539927
37DCP1A_22483619_ChIP-Seq_HELA_Human1.51511549
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.50248922
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48507186
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48325644
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46990584
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43795831
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.41914398
44ELK1_19687146_ChIP-ChIP_HELA_Human1.40945889
45KDM5A_27292631_Chip-Seq_BREAST_Human1.39726438
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39530212
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38883697
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37237292
49GABP_19822575_ChIP-Seq_HepG2_Human1.30885527
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30543715
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28633846
52* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26802374
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26618460
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24230772
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23976082
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22639201
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20482823
58* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19138807
59* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17108173
60ZNF263_19887448_ChIP-Seq_K562_Human1.16939629
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16645702
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11969225
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06709664
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02497541
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02484649
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01041235
67* VDR_21846776_ChIP-Seq_THP-1_Human1.00373436
68ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99991745
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99803103
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99658522
71SOX17_20123909_ChIP-Seq_XEN_Mouse0.99188597
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98716623
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97946780
74STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97723190
75ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95319570
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95077351
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94433406
78YY1_21170310_ChIP-Seq_MESCs_Mouse0.93103255
79* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92554211
80CHD1_26751641_Chip-Seq_LNCaP_Human0.92054738
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91974806
82NANOG_21062744_ChIP-ChIP_HESCs_Human0.91857866
83SRF_21415370_ChIP-Seq_HL-1_Mouse0.91592160
84TFEB_21752829_ChIP-Seq_HELA_Human0.91044920
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88082721
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87845000
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86849870
88* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84982591
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84542777
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82542747
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81613730
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81129526
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80875537
94MYC_18940864_ChIP-ChIP_HL60_Human0.80849042
95SOX2_16153702_ChIP-ChIP_HESCs_Human0.80122283
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79541442
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78224640
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76142823
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74117058
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73486149
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.73464705
102* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73140476
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.73055723
104TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72678703
105SPI1_23547873_ChIP-Seq_NB4_Human0.72121841
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.70583600
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.70224655
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.69778638
109MYB_26560356_Chip-Seq_TH1_Human0.69463539
110PKCTHETA_26484144_Chip-Seq_BREAST_Human0.67864187
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65077444
112UTX_26944678_Chip-Seq_JUKART_Human0.64023795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.98966776
2MP0003111_abnormal_nucleus_morphology4.85903234
3MP0003693_abnormal_embryo_hatching4.75915016
4MP0008057_abnormal_DNA_replication4.14365899
5MP0003077_abnormal_cell_cycle3.97654774
6MP0004957_abnormal_blastocyst_morpholog3.57470419
7MP0008058_abnormal_DNA_repair3.04587718
8MP0008007_abnormal_cellular_replicative2.75473295
9MP0010307_abnormal_tumor_latency2.55701540
10MP0008877_abnormal_DNA_methylation2.55207648
11MP0008932_abnormal_embryonic_tissue2.37030348
12MP0003123_paternal_imprinting2.19861721
13MP0001730_embryonic_growth_arrest2.19570890
14MP0000350_abnormal_cell_proliferation2.15810727
15MP0009697_abnormal_copulation2.01837407
16MP0005076_abnormal_cell_differentiation1.97099051
17MP0010352_gastrointestinal_tract_polyps1.91303764
18MP0001672_abnormal_embryogenesis/_devel1.76648418
19MP0005380_embryogenesis_phenotype1.76648418
20MP0002396_abnormal_hematopoietic_system1.72942884
21MP0004808_abnormal_hematopoietic_stem1.71291220
22MP0003121_genomic_imprinting1.70565520
23MP0003786_premature_aging1.70017556
24MP0001697_abnormal_embryo_size1.66686365
25MP0002085_abnormal_embryonic_tissue1.61588923
26MP0002210_abnormal_sex_determination1.59107912
27MP0003984_embryonic_growth_retardation1.55190850
28MP0004197_abnormal_fetal_growth/weight/1.54285407
29MP0002084_abnormal_developmental_patter1.53197256
30MP0002088_abnormal_embryonic_growth/wei1.50984016
31MP0001929_abnormal_gametogenesis1.50160461
32MP0000490_abnormal_crypts_of1.49609200
33MP0002080_prenatal_lethality1.47880352
34MP0010030_abnormal_orbit_morphology1.47694521
35MP0002086_abnormal_extraembryonic_tissu1.42826709
36MP0000569_abnormal_digit_pigmentation1.42250795
37MP0003890_abnormal_embryonic-extraembry1.41694760
38MP0000313_abnormal_cell_death1.41617905
39MP0009278_abnormal_bone_marrow1.37867800
40MP0004233_abnormal_muscle_weight1.34047400
41MP0001145_abnormal_male_reproductive1.33618563
42MP0003705_abnormal_hypodermis_morpholog1.31455177
43MP0002019_abnormal_tumor_incidence1.30463416
44MP0005451_abnormal_body_composition1.19959006
45MP0001293_anophthalmia1.15680134
46MP0000653_abnormal_sex_gland1.15384636
47MP0003567_abnormal_fetal_cardiomyocyte1.15374549
48MP0000537_abnormal_urethra_morphology1.13184780
49MP0005410_abnormal_fertilization1.13148559
50MP0000703_abnormal_thymus_morphology1.10954186
51MP0003698_abnormal_male_reproductive1.10489899
52MP0004185_abnormal_adipocyte_glucose1.09667594
53MP0000358_abnormal_cell_content/1.09209834
54MP0005397_hematopoietic_system_phenotyp1.06428080
55MP0001545_abnormal_hematopoietic_system1.06428080
56MP0006035_abnormal_mitochondrial_morpho1.05313037
57MP0003937_abnormal_limbs/digits/tail_de1.03959401
58MP0001661_extended_life_span1.01591142
59MP0009053_abnormal_anal_canal1.01076050
60MP0003787_abnormal_imprinting0.99503199
61MP0002653_abnormal_ependyma_morphology0.98513145
62MP0001346_abnormal_lacrimal_gland0.98474859
63MP0009672_abnormal_birth_weight0.96264435
64MP0006054_spinal_hemorrhage0.94762043
65MP0003941_abnormal_skin_development0.93021148
66MP0009703_decreased_birth_body0.92765686
67MP0002398_abnormal_bone_marrow0.91411337
68MP0002697_abnormal_eye_size0.91287380
69MP0001915_intracranial_hemorrhage0.90754102
70MP0010234_abnormal_vibrissa_follicle0.90212100
71MP0003315_abnormal_perineum_morphology0.89203334
72MP0003806_abnormal_nucleotide_metabolis0.88127211
73MP0002009_preneoplasia0.87158720
74MP0005408_hypopigmentation0.86968670
75MP0001119_abnormal_female_reproductive0.86669559
76MP0000733_abnormal_muscle_development0.86376818
77MP0002111_abnormal_tail_morphology0.86140030
78MP0003119_abnormal_digestive_system0.85070337
79MP0002160_abnormal_reproductive_system0.84323854
80MP0002092_abnormal_eye_morphology0.84094894
81MP0003385_abnormal_body_wall0.82552119
82MP0003763_abnormal_thymus_physiology0.81951051
83MP0000015_abnormal_ear_pigmentation0.81763292
84MP0002722_abnormal_immune_system0.81566617
85MP0003115_abnormal_respiratory_system0.81385706
86MP0005501_abnormal_skin_physiology0.80769476
87MP0001727_abnormal_embryo_implantation0.79741040
88MP0006292_abnormal_olfactory_placode0.79309467
89MP0000428_abnormal_craniofacial_morphol0.79168336
90MP0003950_abnormal_plasma_membrane0.78779170
91MP0002095_abnormal_skin_pigmentation0.77999774
92MP0000432_abnormal_head_morphology0.77716235
93MP0005389_reproductive_system_phenotype0.76096005
94MP0003221_abnormal_cardiomyocyte_apopto0.76029516
95MP0003718_maternal_effect0.75999270
96MP0003699_abnormal_female_reproductive0.75968537
97MP0002161_abnormal_fertility/fecundity0.75856247
98MP0001286_abnormal_eye_development0.74342649
99MP0005621_abnormal_cell_physiology0.74126629
100MP0005384_cellular_phenotype0.73852208
101MP0009333_abnormal_splenocyte_physiolog0.73285718
102MP0005171_absent_coat_pigmentation0.73084754
103MP0001849_ear_inflammation0.72951020
104MP0003566_abnormal_cell_adhesion0.71393762
105MP0000566_synostosis0.70785411
106MP0000689_abnormal_spleen_morphology0.70575476
107MP0003935_abnormal_craniofacial_develop0.69903890
108MP0002075_abnormal_coat/hair_pigmentati0.69616940
109MP0003861_abnormal_nervous_system0.68576160
110MP0008789_abnormal_olfactory_epithelium0.68426243
111MP0002932_abnormal_joint_morphology0.68076747
112MP0002938_white_spotting0.66021485
113MP0003136_yellow_coat_color0.65631696
114MP0004264_abnormal_extraembryonic_tissu0.64800492
115MP0002925_abnormal_cardiovascular_devel0.64631771
116MP0000372_irregular_coat_pigmentation0.64615671
117MP0000858_altered_metastatic_potential0.64525143
118MP0000371_diluted_coat_color0.63013483
119MP0005623_abnormal_meninges_morphology0.62782312
120MP0003943_abnormal_hepatobiliary_system0.62363669
121MP0002429_abnormal_blood_cell0.62103304
122MP0003942_abnormal_urinary_system0.61681682
123MP0002233_abnormal_nose_morphology0.60353447
124MP0001186_pigmentation_phenotype0.60045312
125MP0005023_abnormal_wound_healing0.58831911
126MP0008995_early_reproductive_senescence0.58616832
127MP0002877_abnormal_melanocyte_morpholog0.57817489
128MP0003755_abnormal_palate_morphology0.57479825
129MP0002269_muscular_atrophy0.54678325
130MP0000678_abnormal_parathyroid_gland0.53345996

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.58409611
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.54491446
3Cortical dysplasia (HP:0002539)3.58745276
4Abnormality of chromosome stability (HP:0003220)3.54014980
5Impulsivity (HP:0100710)3.53377105
6Meckel diverticulum (HP:0002245)3.31851235
7Selective tooth agenesis (HP:0001592)3.25975012
8Increased nuchal translucency (HP:0010880)3.24986221
9Ectopic kidney (HP:0000086)3.23828679
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.19393327
11Birth length less than 3rd percentile (HP:0003561)3.17687898
12Abnormality of the ileum (HP:0001549)3.14775911
13Abnormality of the preputium (HP:0100587)3.08677435
14Volvulus (HP:0002580)3.02563026
15Small intestinal stenosis (HP:0012848)3.01701812
16Duodenal stenosis (HP:0100867)3.01701812
17Reticulocytopenia (HP:0001896)2.97494671
18Patellar aplasia (HP:0006443)2.89884864
19Colon cancer (HP:0003003)2.82587334
20Ependymoma (HP:0002888)2.76951032
21Myelodysplasia (HP:0002863)2.74323290
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73947406
23Medulloblastoma (HP:0002885)2.72810405
24Sloping forehead (HP:0000340)2.72483501
25Aplasia/Hypoplasia of the patella (HP:0006498)2.70318687
26Abnormality of glycolysis (HP:0004366)2.64488762
27Cholecystitis (HP:0001082)2.63887581
28Abnormal gallbladder physiology (HP:0012438)2.63887581
29Short 4th metacarpal (HP:0010044)2.62073895
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.62073895
31Nephroblastoma (Wilms tumor) (HP:0002667)2.61367884
32Abnormality of the carotid arteries (HP:0005344)2.58032356
33Multiple enchondromatosis (HP:0005701)2.57463541
34Abnormality of the anterior horn cell (HP:0006802)2.54837058
35Degeneration of anterior horn cells (HP:0002398)2.54837058
36High pitched voice (HP:0001620)2.54297582
37Abnormal lung lobation (HP:0002101)2.54109933
3811 pairs of ribs (HP:0000878)2.48974830
39Duplicated collecting system (HP:0000081)2.45850886
40Embryonal renal neoplasm (HP:0011794)2.45683562
41Abnormality of the duodenum (HP:0002246)2.44142278
42Absent radius (HP:0003974)2.42063087
43Breast hypoplasia (HP:0003187)2.42011197
44Microvesicular hepatic steatosis (HP:0001414)2.37336946
45Abnormality of cochlea (HP:0000375)2.36439604
46Absent thumb (HP:0009777)2.35524518
47Abnormal number of incisors (HP:0011064)2.32882910
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.29991796
49Agnosia (HP:0010524)2.29807128
50Abnormality of the renal collecting system (HP:0004742)2.28405657
51Duplication of thumb phalanx (HP:0009942)2.27713548
52Aplasia involving forearm bones (HP:0009822)2.25065924
53Absent forearm bone (HP:0003953)2.25065924
54Deviation of the thumb (HP:0009603)2.24926516
55Proximal placement of thumb (HP:0009623)2.24731757
56Increased serum pyruvate (HP:0003542)2.24575268
57Cafe-au-lait spot (HP:0000957)2.24021260
58Prominent nose (HP:0000448)2.18794632
59Rhabdomyosarcoma (HP:0002859)2.18566276
60Abnormality of reticulocytes (HP:0004312)2.18064066
61Clubbing of toes (HP:0100760)2.17811435
62Astrocytoma (HP:0009592)2.16652144
63Abnormality of the astrocytes (HP:0100707)2.16652144
64Glioma (HP:0009733)2.16612583
65Choanal atresia (HP:0000453)2.15084170
66Bone marrow hypocellularity (HP:0005528)2.13450818
67Embryonal neoplasm (HP:0002898)2.12967658
68Progressive external ophthalmoplegia (HP:0000590)2.12553761
69High anterior hairline (HP:0009890)2.12172524
70Tracheoesophageal fistula (HP:0002575)2.11631389
71Short thumb (HP:0009778)2.10988000
72Broad distal phalanx of finger (HP:0009836)2.10747368
73Missing ribs (HP:0000921)2.10453299
74Atresia of the external auditory canal (HP:0000413)2.10190937
75Aplasia/Hypoplasia of the sternum (HP:0006714)2.03684790
76Neoplasm of the pancreas (HP:0002894)2.02332437
77Abnormality of DNA repair (HP:0003254)2.00914342
78Basal cell carcinoma (HP:0002671)2.00721760
79Abnormality of abdominal situs (HP:0011620)2.00394940
80Abdominal situs inversus (HP:0003363)2.00394940
81Progressive muscle weakness (HP:0003323)1.99043333
82Renal duplication (HP:0000075)1.97229124
83Supernumerary spleens (HP:0009799)1.95939194
84Insomnia (HP:0100785)1.95577503
85Abnormality of the fingertips (HP:0001211)1.94355939
86Abnormality of the labia minora (HP:0012880)1.93853289
87Deep philtrum (HP:0002002)1.91228750
88Abnormality of the calcaneus (HP:0008364)1.89536139
89Ankyloglossia (HP:0010296)1.88328803
90Long eyelashes (HP:0000527)1.86673300
91Facial hemangioma (HP:0000329)1.85722939
92Abnormality of chromosome segregation (HP:0002916)1.85646149
93Aplasia/Hypoplasia of the earlobes (HP:0009906)1.85565766
94Oral leukoplakia (HP:0002745)1.85084317
95Overriding aorta (HP:0002623)1.84950195
96Orthostatic hypotension (HP:0001278)1.84251296
97Triphalangeal thumb (HP:0001199)1.83117135
98Squamous cell carcinoma (HP:0002860)1.82687147
99Neoplasm of the oral cavity (HP:0100649)1.81829462
100Skull defect (HP:0001362)1.80605229
101Carpal bone hypoplasia (HP:0001498)1.79045696
102Facial cleft (HP:0002006)1.78841156
103Neoplasm of striated muscle (HP:0009728)1.77285532
104Poikiloderma (HP:0001029)1.77121574
105Heterotopia (HP:0002282)1.75347303
106Malignant gastrointestinal tract tumors (HP:0006749)1.75134277
107Gastrointestinal carcinoma (HP:0002672)1.75134277
108Spastic diplegia (HP:0001264)1.74858229
109Horseshoe kidney (HP:0000085)1.70831641
110Abnormality of pyrimidine metabolism (HP:0004353)1.70776524
111Neoplasm of the colon (HP:0100273)1.70342140
112Premature graying of hair (HP:0002216)1.69951453
113Abnormality of the 4th metacarpal (HP:0010012)1.69672983
114Ureteral duplication (HP:0000073)1.68624040
115Overlapping toe (HP:0001845)1.68410284
116Morphological abnormality of the inner ear (HP:0011390)1.68196228
117Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67712096
118Absent epiphyses (HP:0010577)1.67712096
119Ovarian neoplasm (HP:0100615)1.67698612
120Cutaneous melanoma (HP:0012056)1.67588082
121Cleft eyelid (HP:0000625)1.67455820
122Small epiphyses (HP:0010585)1.67028640
123Sandal gap (HP:0001852)1.66947962
124Arteriovenous malformation (HP:0100026)1.66174486
125Short middle phalanx of the 5th finger (HP:0004220)1.65896757
126Hyperacusis (HP:0010780)1.65762603
127Entropion (HP:0000621)1.64459549
128Abnormality of cells of the erythroid lineage (HP:0012130)1.64412694
129Obsessive-compulsive behavior (HP:0000722)1.64207933
130Biliary tract neoplasm (HP:0100574)1.63622007
131Abnormality of the umbilical cord (HP:0010881)1.63208969
132Hypoplastic pelvis (HP:0008839)1.61545684
133Leiomyosarcoma (HP:0100243)1.61149054
134Uterine leiomyosarcoma (HP:0002891)1.61149054
135Abnormality of methionine metabolism (HP:0010901)1.56202832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.95330157
2NEK24.13675942
3BUB13.99421353
4WEE13.60631551
5TTK3.14818174
6CDK122.90944560
7NEK12.62901934
8BRSK22.39523438
9SRPK12.36000244
10PLK42.28768429
11PLK12.24222217
12EEF2K2.05511892
13ATR2.03967408
14PASK2.03134807
15AURKB2.02916478
16ZAK1.99539365
17SMG11.94599761
18BRSK11.87121463
19CHEK21.81289543
20BRD41.71506519
21STK41.70959331
22MKNK11.70944277
23VRK21.67802881
24MAP3K101.66145527
25STK101.65865502
26PLK31.65665303
27RPS6KB21.64425504
28TLK11.63487490
29CDK41.55717347
30EIF2AK11.53643225
31CCNB11.52592172
32CHEK11.52346739
33CDK71.50232333
34MAP3K81.50022427
35MST1R1.33103681
36AURKA1.30701727
37TAF11.29382637
38VRK11.27613735
39MKNK21.24124400
40ATM1.22270847
41MELK1.16389656
42TSSK61.16069733
43STK31.14952174
44ACVR1B1.12045081
45CDK61.10617896
46RPS6KA41.00098443
47LATS10.99785869
48PKN20.98714217
49CDK20.95546770
50CLK10.94315936
51DYRK30.92670041
52PAK40.91007359
53PDK40.89563710
54PDK30.89563710
55TESK20.88219331
56PIM10.86603722
57CDK10.85184078
58TESK10.82268971
59SCYL20.81141440
60IRAK30.80611195
61LATS20.79496251
62EPHA20.76594522
63EIF2AK20.75109699
64PNCK0.74245736
65TAOK20.72355923
66MET0.71622002
67ERBB40.62609950
68NME10.60561739
69MTOR0.60271708
70YES10.59715059
71EIF2AK30.57062714
72PBK0.55339871
73ALK0.55120512
74TGFBR10.54892209
75NME20.53973566
76CDK11A0.53569815
77CDK150.53569309
78CDK180.53109280
79RPS6KA50.52442358
80STK160.51941855
81ICK0.50278487
82PAK10.49315707
83PRKDC0.49237817
84CDK90.47844824
85AKT20.45875122
86KSR20.44916990
87TTN0.44650911
88CDK140.43765014
89CSNK2A20.43704648
90CSNK2A10.43520239
91ERBB30.43342776
92MARK30.41406245
93TRIB30.41210168
94MST40.41074872
95AKT10.40559839
96PDGFRA0.39633370
97MAPK140.38683327
98RAF10.38595590
99CSNK1D0.36863658
100CSNK1E0.35815228
101LRRK20.35069324
102PRKCI0.35018051
103MAP4K10.34761026
104FGFR10.32138804
105TRIM280.31530348
106CAMK1G0.31311601
107MAP3K90.30635962
108CAMK1D0.30141052
109TRPM70.30065673
110PDK20.29140548
111CHUK0.28957032
112PTK60.28858764
113STK38L0.28454467
114RPS6KB10.26532440
115PRPF4B0.25627285
116FGFR40.25586395
117KSR10.25374731
118CDK80.25164791
119RPS6KC10.24983822
120RPS6KL10.24983822
121PAK20.24749346
122BTK0.24473767
123* GSK3B0.24342822
124MAPK10.23968335
125MAPK110.23578221
126BMX0.23105114
127DYRK1B0.21829389
128BRAF0.21592343

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.94872550
2Mismatch repair_Homo sapiens_hsa034304.20254607
3Cell cycle_Homo sapiens_hsa041103.40276415
4Homologous recombination_Homo sapiens_hsa034403.25752320
5Base excision repair_Homo sapiens_hsa034103.20823754
6Spliceosome_Homo sapiens_hsa030403.18157403
7Fanconi anemia pathway_Homo sapiens_hsa034603.03993115
8RNA transport_Homo sapiens_hsa030132.96857863
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81433846
10Nucleotide excision repair_Homo sapiens_hsa034202.66495284
11One carbon pool by folate_Homo sapiens_hsa006702.63920621
12Non-homologous end-joining_Homo sapiens_hsa034502.41575466
13Systemic lupus erythematosus_Homo sapiens_hsa053222.29400091
14mRNA surveillance pathway_Homo sapiens_hsa030152.26330527
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11290908
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06376250
17p53 signaling pathway_Homo sapiens_hsa041151.91608689
18RNA polymerase_Homo sapiens_hsa030201.88973998
19RNA degradation_Homo sapiens_hsa030181.83333286
20Pyrimidine metabolism_Homo sapiens_hsa002401.81920989
21Basal transcription factors_Homo sapiens_hsa030221.77791776
22Ribosome_Homo sapiens_hsa030101.70216851
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57498938
24Viral carcinogenesis_Homo sapiens_hsa052031.46207204
25Carbon metabolism_Homo sapiens_hsa012001.43563058
26Proteasome_Homo sapiens_hsa030501.43546120
27Oocyte meiosis_Homo sapiens_hsa041141.41029546
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40405151
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34148972
30Pyruvate metabolism_Homo sapiens_hsa006201.29882490
31Epstein-Barr virus infection_Homo sapiens_hsa051691.19793234
32MicroRNAs in cancer_Homo sapiens_hsa052061.16246701
33Herpes simplex infection_Homo sapiens_hsa051681.15191836
34HTLV-I infection_Homo sapiens_hsa051661.13084604
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12819008
36Alcoholism_Homo sapiens_hsa050341.11966942
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10424609
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03529220
39Small cell lung cancer_Homo sapiens_hsa052221.01522235
40Steroid biosynthesis_Homo sapiens_hsa001000.96258623
41Purine metabolism_Homo sapiens_hsa002300.94446298
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93009926
43Antigen processing and presentation_Homo sapiens_hsa046120.91692765
44Folate biosynthesis_Homo sapiens_hsa007900.76768499
45Chronic myeloid leukemia_Homo sapiens_hsa052200.75934835
46Sulfur relay system_Homo sapiens_hsa041220.74262331
47Fructose and mannose metabolism_Homo sapiens_hsa000510.73398573
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71616246
49Selenocompound metabolism_Homo sapiens_hsa004500.71396479
50Pentose phosphate pathway_Homo sapiens_hsa000300.71148123
51Basal cell carcinoma_Homo sapiens_hsa052170.71081559
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70871437
53Lysine degradation_Homo sapiens_hsa003100.69070435
54Colorectal cancer_Homo sapiens_hsa052100.68501518
55Apoptosis_Homo sapiens_hsa042100.65921580
56Hepatitis B_Homo sapiens_hsa051610.65484311
57Measles_Homo sapiens_hsa051620.65090177
58Adherens junction_Homo sapiens_hsa045200.64867399
59Notch signaling pathway_Homo sapiens_hsa043300.63886488
60Fatty acid elongation_Homo sapiens_hsa000620.63314591
61Hippo signaling pathway_Homo sapiens_hsa043900.62894879
62Primary immunodeficiency_Homo sapiens_hsa053400.62268976
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61374521
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61257922
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.61160896
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59241923
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59150454
68Vitamin B6 metabolism_Homo sapiens_hsa007500.58834070
69TGF-beta signaling pathway_Homo sapiens_hsa043500.57965699
70Galactose metabolism_Homo sapiens_hsa000520.57280607
71Legionellosis_Homo sapiens_hsa051340.56996184
72Glutathione metabolism_Homo sapiens_hsa004800.56133334
73Influenza A_Homo sapiens_hsa051640.52906369
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50793549
75mTOR signaling pathway_Homo sapiens_hsa041500.49264225
76Thyroid cancer_Homo sapiens_hsa052160.49205939
77Non-small cell lung cancer_Homo sapiens_hsa052230.48958940
78Prostate cancer_Homo sapiens_hsa052150.48048896
79Viral myocarditis_Homo sapiens_hsa054160.47229011
80Protein export_Homo sapiens_hsa030600.46770343
81Bladder cancer_Homo sapiens_hsa052190.45964919
82Propanoate metabolism_Homo sapiens_hsa006400.44388099
83Shigellosis_Homo sapiens_hsa051310.44325467
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.43581317
85Biosynthesis of amino acids_Homo sapiens_hsa012300.42868676
86Pancreatic cancer_Homo sapiens_hsa052120.42541938
87Pathways in cancer_Homo sapiens_hsa052000.41198274
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40951517
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.40543657
90Huntingtons disease_Homo sapiens_hsa050160.38890231
91Hedgehog signaling pathway_Homo sapiens_hsa043400.38846824
92FoxO signaling pathway_Homo sapiens_hsa040680.37878220
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36796508
94Fatty acid metabolism_Homo sapiens_hsa012120.36388301
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36267220
96B cell receptor signaling pathway_Homo sapiens_hsa046620.36037698
97Arginine biosynthesis_Homo sapiens_hsa002200.35672316
98Endometrial cancer_Homo sapiens_hsa052130.35364130
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35203336
100HIF-1 signaling pathway_Homo sapiens_hsa040660.35045201
101N-Glycan biosynthesis_Homo sapiens_hsa005100.33990623
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33546715
103Proteoglycans in cancer_Homo sapiens_hsa052050.33239166
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33023248
105Melanoma_Homo sapiens_hsa052180.32943461
106Wnt signaling pathway_Homo sapiens_hsa043100.32636371
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.32364750
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.31086142
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30949070
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30865594
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28092918
112Hematopoietic cell lineage_Homo sapiens_hsa046400.27622487
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26707599
114Arginine and proline metabolism_Homo sapiens_hsa003300.26029727
115Acute myeloid leukemia_Homo sapiens_hsa052210.25163200
116Glioma_Homo sapiens_hsa052140.24813611
117Metabolic pathways_Homo sapiens_hsa011000.24779114
118Leishmaniasis_Homo sapiens_hsa051400.22737244
119Toxoplasmosis_Homo sapiens_hsa051450.22659351
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.21146269
121Tight junction_Homo sapiens_hsa045300.20701953
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18030098
123Asthma_Homo sapiens_hsa053100.17373346
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17192264
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17161507
126T cell receptor signaling pathway_Homo sapiens_hsa046600.16991750
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16116738
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.14742460
129Parkinsons disease_Homo sapiens_hsa050120.12759236

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