SPAG7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.50739417
2ribosomal small subunit assembly (GO:0000028)5.16807781
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.86738002
4cytidine metabolic process (GO:0046087)4.65797689
5cytidine catabolic process (GO:0006216)4.65797689
6cytidine deamination (GO:0009972)4.65797689
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.64888522
8ATP synthesis coupled proton transport (GO:0015986)4.64888522
9cullin deneddylation (GO:0010388)4.63288630
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.53141352
11protein deneddylation (GO:0000338)4.51757363
12formation of translation preinitiation complex (GO:0001731)4.51019062
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.38320792
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.32052823
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.32052823
16NADH dehydrogenase complex assembly (GO:0010257)4.32052823
17viral mRNA export from host cell nucleus (GO:0046784)4.31268500
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.23842600
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.18981299
20protein complex biogenesis (GO:0070271)4.14857505
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.11411362
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.11392985
23negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.10904706
24negative regulation of ligase activity (GO:0051352)4.10904706
25water-soluble vitamin biosynthetic process (GO:0042364)4.07624533
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.03158112
27intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.03158112
28DNA deamination (GO:0045006)4.03013803
29signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.02858200
30signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.02858200
31signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.02858200
32ubiquinone biosynthetic process (GO:0006744)4.02607020
33regulation of cellular amino acid metabolic process (GO:0006521)4.01982440
34maturation of SSU-rRNA (GO:0030490)4.00473128
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.99367504
36termination of RNA polymerase III transcription (GO:0006386)3.99367504
37pyrimidine ribonucleoside catabolic process (GO:0046133)3.99304362
38protein neddylation (GO:0045116)3.98839712
39oxidative phosphorylation (GO:0006119)3.95107541
40chaperone-mediated protein transport (GO:0072321)3.92568013
41signal transduction involved in DNA damage checkpoint (GO:0072422)3.89747665
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.89747665
437-methylguanosine mRNA capping (GO:0006370)3.86434634
44L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.86105943
45signal transduction involved in cell cycle checkpoint (GO:0072395)3.85846041
46mitochondrial respiratory chain complex assembly (GO:0033108)3.84841764
47purine nucleobase biosynthetic process (GO:0009113)3.84685399
48ribosomal small subunit biogenesis (GO:0042274)3.84176894
49ubiquinone metabolic process (GO:0006743)3.80987020
50RNA capping (GO:0036260)3.79005976
517-methylguanosine RNA capping (GO:0009452)3.79005976
52peptidyl-histidine modification (GO:0018202)3.77732465
53respiratory chain complex IV assembly (GO:0008535)3.74351605
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.74166149
55regulation of mitochondrial translation (GO:0070129)3.73532047
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.73186799
57nucleobase biosynthetic process (GO:0046112)3.73174003
58actin-myosin filament sliding (GO:0033275)3.66616235
59muscle filament sliding (GO:0030049)3.66616235
60positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.66007675
61viral transcription (GO:0019083)3.65665328
62telomere maintenance via semi-conservative replication (GO:0032201)3.65309016
63establishment of protein localization to mitochondrial membrane (GO:0090151)3.59969435
64respiratory electron transport chain (GO:0022904)3.56971709
65translational termination (GO:0006415)3.55789803
66platelet dense granule organization (GO:0060155)3.55290924
67ribosomal large subunit biogenesis (GO:0042273)3.55128199
68electron transport chain (GO:0022900)3.52695155
69positive regulation of ligase activity (GO:0051351)3.49996139
70SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.48751339
71rRNA modification (GO:0000154)3.48455784
72translation (GO:0006412)3.48439472
73cytochrome complex assembly (GO:0017004)3.47296613
74antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.46413148
75DNA strand elongation involved in DNA replication (GO:0006271)3.45221234
76cotranslational protein targeting to membrane (GO:0006613)3.42496316
77base-excision repair, AP site formation (GO:0006285)3.41894226
78cellular component biogenesis (GO:0044085)3.41180065
79positive regulation of prostaglandin secretion (GO:0032308)3.38250595
80metallo-sulfur cluster assembly (GO:0031163)3.37717793
81iron-sulfur cluster assembly (GO:0016226)3.37717793
82ribonucleoprotein complex biogenesis (GO:0022613)3.37643851
83protein targeting to ER (GO:0045047)3.37132504
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.35970649
85behavioral response to nicotine (GO:0035095)3.35923699
86maturation of 5.8S rRNA (GO:0000460)3.35905109
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35362458
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35362458
89negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.34177022
90transcription-coupled nucleotide-excision repair (GO:0006283)3.33839883
91spliceosomal snRNP assembly (GO:0000387)3.33469918
92branched-chain amino acid catabolic process (GO:0009083)3.32335455
93telomere maintenance via recombination (GO:0000722)3.32292130
94translational elongation (GO:0006414)3.31291847
95ATP biosynthetic process (GO:0006754)3.30551423
96positive regulation of cell cycle arrest (GO:0071158)3.29791249
97DNA strand elongation (GO:0022616)3.28649710
98translational initiation (GO:0006413)3.25603393
99hydrogen ion transmembrane transport (GO:1902600)3.25101409
100protein localization to endoplasmic reticulum (GO:0070972)3.24373059
101guanosine-containing compound biosynthetic process (GO:1901070)3.23592488
102regulation of ubiquitin-protein transferase activity (GO:0051438)3.22931242
103DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.22796808
104deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22328502
105protein targeting to mitochondrion (GO:0006626)3.22057399
106heart process (GO:0003015)3.18457120
107heart contraction (GO:0060047)3.18457120
108ribosome biogenesis (GO:0042254)3.17924808
109negative regulation of telomere maintenance (GO:0032205)3.16826849
110regulation of skeletal muscle contraction (GO:0014819)3.16739901
111establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16347291
112DNA replication checkpoint (GO:0000076)3.14760115
113establishment of protein localization to mitochondrion (GO:0072655)3.14586565
114nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14577651
115mitotic metaphase plate congression (GO:0007080)3.13311504
116regulation of ligase activity (GO:0051340)3.11368449
117transcription elongation from RNA polymerase I promoter (GO:0006362)3.10861983
118deoxyribonucleotide catabolic process (GO:0009264)3.10777250
119exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10572655
120cell cycle G1/S phase transition (GO:0044843)3.09576047
121G1/S transition of mitotic cell cycle (GO:0000082)3.09576047
122CENP-A containing nucleosome assembly (GO:0034080)3.08486675
123quinone biosynthetic process (GO:1901663)3.07880679
124proton transport (GO:0015992)3.07543304
125transcription from RNA polymerase I promoter (GO:0006360)3.06181374
126rRNA processing (GO:0006364)3.05990017
127hydrogen transport (GO:0006818)3.02767596
128purine nucleoside triphosphate biosynthetic process (GO:0009145)3.01941847
129purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.00134788
130pseudouridine synthesis (GO:0001522)2.98875228
131mannosylation (GO:0097502)2.92967290
132deoxyribose phosphate catabolic process (GO:0046386)2.90867218
133actin-mediated cell contraction (GO:0070252)2.89944723
134amino acid salvage (GO:0043102)2.87842213
135L-methionine salvage (GO:0071267)2.87842213
136L-methionine biosynthetic process (GO:0071265)2.87842213
137aerobic respiration (GO:0009060)2.79876079
138pyrimidine nucleotide catabolic process (GO:0006244)2.76514401
139intracellular protein transmembrane import (GO:0044743)2.74252629
140protein localization to mitochondrion (GO:0070585)2.72786686
141preassembly of GPI anchor in ER membrane (GO:0016254)2.68740957
142aldehyde catabolic process (GO:0046185)2.67670778
143deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.67130667
144ribonucleoside triphosphate biosynthetic process (GO:0009201)2.66919373
145purine deoxyribonucleotide catabolic process (GO:0009155)2.66547590
146branched-chain amino acid metabolic process (GO:0009081)2.62811461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.81682161
2EST1_17652178_ChIP-ChIP_JURKAT_Human4.26930737
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.24142981
4E2F7_22180533_ChIP-Seq_HELA_Human4.21790570
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.18890905
6GABP_17652178_ChIP-ChIP_JURKAT_Human4.16119350
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.76303559
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.68726804
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62378701
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.49575514
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.37337693
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.23613791
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.14070438
14* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.08214315
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.04800407
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89676421
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79167947
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70567720
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69828151
20* SRF_21415370_ChIP-Seq_HL-1_Mouse2.69822175
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.64476643
22* VDR_23849224_ChIP-Seq_CD4+_Human2.62827615
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.57696717
24ZNF274_21170338_ChIP-Seq_K562_Hela2.47455348
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.47012132
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.45068123
27DCP1A_22483619_ChIP-Seq_HELA_Human2.39044419
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38180238
29XRN2_22483619_ChIP-Seq_HELA_Human2.37969916
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.36225438
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32429319
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31335616
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23015777
34GABP_19822575_ChIP-Seq_HepG2_Human2.22381072
35FOXP3_21729870_ChIP-Seq_TREG_Human2.20689019
36ELK1_19687146_ChIP-ChIP_HELA_Human2.14407696
37TTF2_22483619_ChIP-Seq_HELA_Human2.09142246
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00923910
39* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93438881
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92029631
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91567701
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84471699
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81297917
44VDR_22108803_ChIP-Seq_LS180_Human1.79547146
45* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79424156
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78870694
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77552584
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.74921461
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74150407
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67215741
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66307975
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65225690
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.62697840
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62656669
55* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54642863
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53354618
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51788310
58IGF1R_20145208_ChIP-Seq_DFB_Human1.48963166
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.46270237
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.46217585
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44330390
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42597308
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42562201
64TP53_22573176_ChIP-Seq_HFKS_Human1.41823587
65CIITA_25753668_ChIP-Seq_RAJI_Human1.40668017
66* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39037050
67* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34955519
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.34918659
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32007951
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.31650499
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29406472
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28464467
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27519127
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24416899
75EZH2_22144423_ChIP-Seq_EOC_Human1.24184837
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.23018182
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19577191
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19473997
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17361211
80MYC_19829295_ChIP-Seq_ESCs_Human1.13767974
81NANOG_20526341_ChIP-Seq_ESCs_Human1.12885859
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11857658
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10239963
84AR_20517297_ChIP-Seq_VCAP_Human1.09927921
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09389541
86KDM5A_27292631_Chip-Seq_BREAST_Human1.09304694
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09028906
88EWS_26573619_Chip-Seq_HEK293_Human1.08554964
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08358933
90* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06738000
91NANOG_19829295_ChIP-Seq_ESCs_Human1.05217570
92SOX2_19829295_ChIP-Seq_ESCs_Human1.05217570
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04475549
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03803655
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03151972
96HTT_18923047_ChIP-ChIP_STHdh_Human1.03008845
97IRF1_19129219_ChIP-ChIP_H3396_Human1.02419542
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02367482
99MYC_18940864_ChIP-ChIP_HL60_Human1.01978481
100GATA3_21878914_ChIP-Seq_MCF-7_Human1.01708118
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00697127
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00692448
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00369193
104E2F1_21310950_ChIP-Seq_MCF-7_Human0.99819397
105SOX2_16153702_ChIP-ChIP_HESCs_Human0.99390213
106AR_21909140_ChIP-Seq_LNCAP_Human0.97736960
107TP63_19390658_ChIP-ChIP_HaCaT_Human0.97728753
108EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97051924
109FOXA1_25329375_ChIP-Seq_VCAP_Human0.96432855
110FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96432855
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95391535
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93653291
113FOXP1_21924763_ChIP-Seq_HESCs_Human0.93529661
114* SOX17_20123909_ChIP-Seq_XEN_Mouse0.91779732
115FOXH1_21741376_ChIP-Seq_EPCs_Human0.91628642
116* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91274414
117TAF2_19829295_ChIP-Seq_ESCs_Human0.91070787
118P53_21459846_ChIP-Seq_SAOS-2_Human0.90804312
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90157392
120* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89645104
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89554405
122BCL6_27268052_Chip-Seq_Bcells_Human0.87967921
123FUS_26573619_Chip-Seq_HEK293_Human0.87962635
124OCT4_20526341_ChIP-Seq_ESCs_Human0.86088224
125NCOR_22424771_ChIP-Seq_293T_Human0.86010800
126NOTCH1_21737748_ChIP-Seq_TLL_Human0.85564672
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85407612
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85342485
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81311315
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81092220
131* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80412175
132TFEB_21752829_ChIP-Seq_HELA_Human0.79264472
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78188480
134* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.78000425
135TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76628873
136SPI1_23547873_ChIP-Seq_NB4_Human0.75144982
137EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74040790
138KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.73059820
139* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72671122
140ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.71990866
141GATA4_21415370_ChIP-Seq_HL-1_Mouse0.70711804
142YY1_22570637_ChIP-Seq_MALME-3M_Human0.69619004
143* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.69342927
144NANOG_16153702_ChIP-ChIP_HESCs_Human0.67250012
145KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.66821210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.81153137
2MP0004957_abnormal_blastocyst_morpholog3.42608597
3MP0003077_abnormal_cell_cycle3.00546183
4MP0010094_abnormal_chromosome_stability2.95381988
5MP0008058_abnormal_DNA_repair2.92532117
6MP0003111_abnormal_nucleus_morphology2.86007668
7MP0006292_abnormal_olfactory_placode2.83380165
8MP0008932_abnormal_embryonic_tissue2.48172824
9MP0003646_muscle_fatigue2.45244370
10MP0008057_abnormal_DNA_replication2.40820658
11MP0003011_delayed_dark_adaptation2.37436749
12MP0008007_abnormal_cellular_replicative2.36420929
13MP0008877_abnormal_DNA_methylation2.33090855
14MP0004084_abnormal_cardiac_muscle2.31796730
15MP0003123_paternal_imprinting2.29511078
16MP0003137_abnormal_impulse_conducting2.15926269
17MP0002254_reproductive_system_inflammat2.15621641
18MP0006036_abnormal_mitochondrial_physio2.10049838
19MP0006072_abnormal_retinal_apoptosis2.09585199
20MP0000749_muscle_degeneration2.06650103
21MP0003195_calcinosis2.05714763
22MP0003122_maternal_imprinting2.03619705
23MP0003786_premature_aging1.96781136
24MP0003806_abnormal_nucleotide_metabolis1.91340308
25MP0002837_dystrophic_cardiac_calcinosis1.86306009
26MP0002638_abnormal_pupillary_reflex1.83400393
27MP0003718_maternal_effect1.82610713
28MP0009379_abnormal_foot_pigmentation1.79570329
29MP0001529_abnormal_vocalization1.78136569
30MP0001986_abnormal_taste_sensitivity1.75978391
31MP0003186_abnormal_redox_activity1.73625647
32MP0009697_abnormal_copulation1.72260696
33MP0004036_abnormal_muscle_relaxation1.71887064
34MP0003121_genomic_imprinting1.70878451
35MP0005253_abnormal_eye_physiology1.56791937
36MP0004133_heterotaxia1.56231551
37MP0003567_abnormal_fetal_cardiomyocyte1.53474830
38MP0002653_abnormal_ependyma_morphology1.49711123
39MP0000372_irregular_coat_pigmentation1.48624005
40MP0002396_abnormal_hematopoietic_system1.46578176
41MP0001485_abnormal_pinna_reflex1.45996521
42MP0005551_abnormal_eye_electrophysiolog1.44966936
43MP0006035_abnormal_mitochondrial_morpho1.44544337
44MP0008875_abnormal_xenobiotic_pharmacok1.44315495
45MP0002938_white_spotting1.44238613
46MP0001984_abnormal_olfaction1.44234592
47MP0004142_abnormal_muscle_tone1.44192012
48MP0001905_abnormal_dopamine_level1.44179886
49MP0005671_abnormal_response_to1.43914960
50MP0000751_myopathy1.42887996
51MP0003787_abnormal_imprinting1.41003619
52MP0004215_abnormal_myocardial_fiber1.40660734
53MP0003315_abnormal_perineum_morphology1.39730739
54MP0005394_taste/olfaction_phenotype1.39215699
55MP0005499_abnormal_olfactory_system1.39215699
56MP0006054_spinal_hemorrhage1.37032490
57MP0008872_abnormal_physiological_respon1.36545370
58MP0005084_abnormal_gallbladder_morpholo1.34333685
59MP0002234_abnormal_pharynx_morphology1.33540034
60MP0002127_abnormal_cardiovascular_syste1.32913057
61MP0002163_abnormal_gland_morphology1.31396418
62MP0004145_abnormal_muscle_electrophysio1.30726571
63MP0004147_increased_porphyrin_level1.28989372
64MP0002132_abnormal_respiratory_system1.23397829
65MP0003221_abnormal_cardiomyocyte_apopto1.22629296
66MP0005330_cardiomyopathy1.21258891
67MP0010030_abnormal_orbit_morphology1.20270701
68MP0001730_embryonic_growth_arrest1.16335748
69MP0002106_abnormal_muscle_physiology1.13258266
70MP0008995_early_reproductive_senescence1.09809350
71MP0001968_abnormal_touch/_nociception1.06599697
72MP0005377_hearing/vestibular/ear_phenot1.05499077
73MP0003878_abnormal_ear_physiology1.05499077
74MP0000350_abnormal_cell_proliferation1.05261247
75MP0002102_abnormal_ear_morphology1.04283262
76MP0002160_abnormal_reproductive_system1.03940830
77MP0003941_abnormal_skin_development1.03415574
78MP0010386_abnormal_urinary_bladder1.03226885
79MP0005075_abnormal_melanosome_morpholog1.01148336
80MP0000313_abnormal_cell_death1.00498316
81MP0004085_abnormal_heartbeat1.00458064
82MP0002876_abnormal_thyroid_physiology1.00098573
83MP0005646_abnormal_pituitary_gland0.99718821
84MP0009840_abnormal_foam_cell0.98872553
85MP0002972_abnormal_cardiac_muscle0.98127487
86MP0006276_abnormal_autonomic_nervous0.95965988
87MP0001544_abnormal_cardiovascular_syste0.95098281
88MP0005385_cardiovascular_system_phenoty0.95098281
89MP0005645_abnormal_hypothalamus_physiol0.94966780
90MP0000678_abnormal_parathyroid_gland0.94470343
91MP0009764_decreased_sensitivity_to0.94388802
92MP0002751_abnormal_autonomic_nervous0.94173004
93MP0001697_abnormal_embryo_size0.93606357
94MP0005332_abnormal_amino_acid0.93017304
95MP0002148_abnormal_hypersensitivity_rea0.91609287
96MP0001293_anophthalmia0.91153386
97MP0002090_abnormal_vision0.91067762
98MP0000750_abnormal_muscle_regeneration0.90744221
99MP0000358_abnormal_cell_content/0.89168874
100MP0003136_yellow_coat_color0.88792567
101MP0002736_abnormal_nociception_after0.88781281
102MP0005266_abnormal_metabolism0.88731128
103MP0009785_altered_susceptibility_to0.88675389
104MP0005389_reproductive_system_phenotype0.88099040
105MP0005410_abnormal_fertilization0.87390808
106MP0005171_absent_coat_pigmentation0.87316814
107MP0008260_abnormal_autophagy0.85601067
108MP0001873_stomach_inflammation0.85398613
109MP0001764_abnormal_homeostasis0.85290918
110MP0008789_abnormal_olfactory_epithelium0.84794440
111MP0005379_endocrine/exocrine_gland_phen0.84677577
112MP0005369_muscle_phenotype0.84471584
113MP0003880_abnormal_central_pattern0.84174299
114MP0002080_prenatal_lethality0.82714797
115MP0005397_hematopoietic_system_phenotyp0.82441513
116MP0001545_abnormal_hematopoietic_system0.82441513
117MP0004808_abnormal_hematopoietic_stem0.82133448
118MP0000566_synostosis0.81946005
119MP0009046_muscle_twitch0.80448355
120MP0000490_abnormal_crypts_of0.80417037
121MP0002822_catalepsy0.80385289
122MP0000049_abnormal_middle_ear0.79480716
123MP0006138_congestive_heart_failure0.79324376
124MP0002138_abnormal_hepatobiliary_system0.79062939
125MP0001672_abnormal_embryogenesis/_devel0.77650132
126MP0005380_embryogenesis_phenotype0.77650132
127MP0002210_abnormal_sex_determination0.77563580
128MP0004087_abnormal_muscle_fiber0.77250962
129MP0005408_hypopigmentation0.77204943
130MP0000343_altered_response_to0.74913777
131MP0000230_abnormal_systemic_arterial0.74641993
132MP0001542_abnormal_bone_strength0.74507160
133MP0001188_hyperpigmentation0.73694236
134MP0002272_abnormal_nervous_system0.72815962
135MP0004782_abnormal_surfactant_physiolog0.72652621
136MP0001727_abnormal_embryo_implantation0.72251404
137MP0002332_abnormal_exercise_endurance0.71901161
138MP0003984_embryonic_growth_retardation0.71701350
139MP0002735_abnormal_chemical_nociception0.71502888
140MP0008775_abnormal_heart_ventricle0.71388063
141MP0002269_muscular_atrophy0.70159298
142MP0002277_abnormal_respiratory_mucosa0.70147194
143MP0002095_abnormal_skin_pigmentation0.69842931
144MP0002088_abnormal_embryonic_growth/wei0.69324557
145MP0009745_abnormal_behavioral_response0.68949226
146MP0005620_abnormal_muscle_contractility0.68905375
147MP0004484_altered_response_of0.68165547
148MP0005636_abnormal_mineral_homeostasis0.66323104

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.55667695
2Abnormal mitochondria in muscle tissue (HP:0008316)5.07990554
3Hepatocellular necrosis (HP:0001404)5.07928628
4Mitochondrial inheritance (HP:0001427)5.02919477
5Increased CSF lactate (HP:0002490)4.65712316
6Hepatic necrosis (HP:0002605)4.63735375
7Progressive macrocephaly (HP:0004481)4.32706314
8Acute encephalopathy (HP:0006846)4.24196182
9Increased serum lactate (HP:0002151)3.52526874
10Increased hepatocellular lipid droplets (HP:0006565)3.50026019
11Exercise intolerance (HP:0003546)3.48187328
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.41215591
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.41215591
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.37560563
15Abnormality of cells of the erythroid lineage (HP:0012130)3.31841018
16Birth length less than 3rd percentile (HP:0003561)3.29194498
173-Methylglutaconic aciduria (HP:0003535)3.28238053
18Reticulocytopenia (HP:0001896)3.25344620
19Lipid accumulation in hepatocytes (HP:0006561)3.24912835
20Abnormality of glycolysis (HP:0004366)3.20131243
21Increased serum pyruvate (HP:0003542)3.20131243
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.19905538
23Lactic acidosis (HP:0003128)3.14838470
24Abnormal number of erythroid precursors (HP:0012131)3.12405774
25Respiratory failure (HP:0002878)3.08192147
26Aplastic anemia (HP:0001915)3.07717910
27Nemaline bodies (HP:0003798)3.05913549
28Muscle fiber inclusion bodies (HP:0100299)3.03379226
29Abnormality of midbrain morphology (HP:0002418)3.00174792
30Molar tooth sign on MRI (HP:0002419)3.00174792
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.94251355
32Exertional dyspnea (HP:0002875)2.93761818
33Hyperglycinemia (HP:0002154)2.86030185
34Cerebral hypomyelination (HP:0006808)2.85223881
35Type I transferrin isoform profile (HP:0003642)2.82987703
36Exercise-induced muscle cramps (HP:0003710)2.72134711
37Cerebral edema (HP:0002181)2.62583087
38Renal Fanconi syndrome (HP:0001994)2.61598378
39Methylmalonic aciduria (HP:0012120)2.60789036
40Lethargy (HP:0001254)2.58886756
41Oral leukoplakia (HP:0002745)2.58322437
42Methylmalonic acidemia (HP:0002912)2.56258389
43Abolished electroretinogram (ERG) (HP:0000550)2.53413628
44Dicarboxylic aciduria (HP:0003215)2.52932346
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52932346
46Patellar aplasia (HP:0006443)2.46970132
47Increased intramyocellular lipid droplets (HP:0012240)2.46417310
48CNS demyelination (HP:0007305)2.46113704
49Type 2 muscle fiber atrophy (HP:0003554)2.43489970
50Optic disc pallor (HP:0000543)2.43338474
51Respiratory difficulties (HP:0002880)2.40755810
52Hyperglycinuria (HP:0003108)2.36070714
53Palpitations (HP:0001962)2.36039434
54Aplasia/Hypoplasia of the patella (HP:0006498)2.32632132
55Leukodystrophy (HP:0002415)2.32446836
56Breast hypoplasia (HP:0003187)2.31307757
57Rough bone trabeculation (HP:0100670)2.30398510
58Emotional lability (HP:0000712)2.29435366
59Carpal bone hypoplasia (HP:0001498)2.28184358
60Microvesicular hepatic steatosis (HP:0001414)2.26125144
61Abnormality of serine family amino acid metabolism (HP:0010894)2.24257986
62Abnormality of glycine metabolism (HP:0010895)2.24257986
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23724926
64Macrocytic anemia (HP:0001972)2.23712298
65Myotonia (HP:0002486)2.23512129
66Degeneration of anterior horn cells (HP:0002398)2.22488573
67Abnormality of the anterior horn cell (HP:0006802)2.22488573
68Nephronophthisis (HP:0000090)2.17254343
69Myoglobinuria (HP:0002913)2.16504607
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16326684
71Abnormality of alanine metabolism (HP:0010916)2.16326684
72Hyperalaninemia (HP:0003348)2.16326684
73Abnormality of the labia minora (HP:0012880)2.15817641
74Abnormality of the preputium (HP:0100587)2.14472187
75Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13793698
76Increased muscle lipid content (HP:0009058)2.13086207
77Muscle fiber atrophy (HP:0100295)2.12619354
78Congenital stationary night blindness (HP:0007642)2.12174205
79Renal cortical cysts (HP:0000803)2.03334234
80Pancreatic fibrosis (HP:0100732)2.02552418
81Generalized aminoaciduria (HP:0002909)2.01607844
82Abnormal hair whorl (HP:0010721)2.01432692
83Meckel diverticulum (HP:0002245)2.00676416
84Irregular epiphyses (HP:0010582)2.00497060
85Pallor (HP:0000980)1.99755973
86Glycosuria (HP:0003076)1.99688737
87Abnormality of urine glucose concentration (HP:0011016)1.99688737
88Abnormal lung lobation (HP:0002101)1.98191304
89Microretrognathia (HP:0000308)1.97152827
90Abnormality of the ileum (HP:0001549)1.94491249
91Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93876605
92Chromsome breakage (HP:0040012)1.92973539
93Abnormality of serum amino acid levels (HP:0003112)1.92569242
94Hypothermia (HP:0002045)1.92510682
95Rhabdomyolysis (HP:0003201)1.92504915
96Unsteady gait (HP:0002317)1.91322335
97True hermaphroditism (HP:0010459)1.90154992
98X-linked dominant inheritance (HP:0001423)1.90134960
99Patent foramen ovale (HP:0001655)1.88982052
100Neoplasm of the adrenal gland (HP:0100631)1.87552030
101Pancreatic cysts (HP:0001737)1.86316898
102Rimmed vacuoles (HP:0003805)1.84321658
103Increased IgM level (HP:0003496)1.83872371
104Double outlet right ventricle (HP:0001719)1.83185528
105Congenital malformation of the right heart (HP:0011723)1.83185528
106Nausea (HP:0002018)1.83078692
107Premature graying of hair (HP:0002216)1.82274874
108Abnormal trabecular bone morphology (HP:0100671)1.82169104
109Medial flaring of the eyebrow (HP:0010747)1.81872416
110Pancytopenia (HP:0001876)1.81192391
111Colon cancer (HP:0003003)1.80390311
112Attenuation of retinal blood vessels (HP:0007843)1.80239161
113Abnormal biliary tract physiology (HP:0012439)1.79428325
114Bile duct proliferation (HP:0001408)1.79428325
115Nephrogenic diabetes insipidus (HP:0009806)1.78973305
116Calf muscle hypertrophy (HP:0008981)1.77534800
117Neuroendocrine neoplasm (HP:0100634)1.77237156
118Gait imbalance (HP:0002141)1.77061973
119Left ventricular hypertrophy (HP:0001712)1.76948959
120Ketosis (HP:0001946)1.76731560
121Abnormality of the renal cortex (HP:0011035)1.76721984
122Decreased central vision (HP:0007663)1.74682789
123Abnormal protein glycosylation (HP:0012346)1.73169657
124Abnormal glycosylation (HP:0012345)1.73169657
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73169657
126Abnormal protein N-linked glycosylation (HP:0012347)1.73169657
127Absent thumb (HP:0009777)1.72836440
128Adrenal hypoplasia (HP:0000835)1.72805497
129Congenital primary aphakia (HP:0007707)1.70532039
130Muscle hypertrophy of the lower extremities (HP:0008968)1.70071572
131Multiple enchondromatosis (HP:0005701)1.69980328
132Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69737177
133Bone marrow hypocellularity (HP:0005528)1.69581116
134Blindness (HP:0000618)1.69281979
135Exercise-induced myalgia (HP:0003738)1.68145201
136Esophageal neoplasm (HP:0100751)1.67592060
137Neoplasm of head and neck (HP:0012288)1.67592060
138Abnormal rod and cone electroretinograms (HP:0008323)1.67405850
139Cerebral palsy (HP:0100021)1.67192763
140Delayed CNS myelination (HP:0002188)1.66595625
141Aplasia/Hypoplasia of the uvula (HP:0010293)1.66364522
142Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64567495
143Absent epiphyses (HP:0010577)1.64567495
144Metabolic acidosis (HP:0001942)1.64530219
145Sclerocornea (HP:0000647)1.62798630
146Absent rod-and cone-mediated responses on ERG (HP:0007688)1.61976829
147Anencephaly (HP:0002323)1.59130122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.28247713
2STK163.60944949
3WEE13.05085692
4NME22.87756666
5VRK22.86879856
6EIF2AK12.75335494
7TSSK62.69119927
8SRPK12.68864724
9OBSCN2.28453449
10MAP4K22.27729245
11MYLK2.26030284
12NUAK12.24667418
13PIM22.23082149
14PLK42.15496281
15EIF2AK32.13409118
16VRK12.05241597
17TXK1.99174967
18ZAK1.98734226
19ARAF1.97844769
20CCNB11.96549124
21WNK31.91859304
22GRK11.80793755
23PDK21.77118590
24NME11.76127322
25BRSK21.75813453
26MAP3K121.73969377
27BRAF1.73534946
28NEK11.68961883
29CDK81.56247976
30MKNK11.55363243
31FRK1.53309531
32AKT31.50903239
33MUSK1.50588276
34PHKG11.47763642
35PHKG21.47763642
36PLK31.47519791
37CSNK1G31.44470788
38SIK31.44115859
39MAPKAPK31.43830816
40TRIM281.39671658
41ADRBK21.38919318
42CDC71.36012447
43ACVR1B1.32513687
44PLK11.31695744
45CSNK1G11.27069553
46PIK3CA1.26992580
47CSNK1G21.25511949
48TGFBR11.20884363
49MKNK21.15634741
50BRSK11.09641133
51CASK1.08471072
52STK241.08209037
53CSNK1A1L1.07488712
54OXSR11.06367066
55INSRR1.04365308
56MST41.04171985
57PASK1.04034548
58DYRK21.02012297
59LIMK10.98963854
60TTK0.97378807
61STK38L0.95045674
62TAOK20.94391504
63AURKB0.92683567
64BCKDK0.92096175
65AURKA0.90123403
66DAPK30.88526468
67RPS6KB20.88310245
68EIF2AK20.87831348
69CDK70.86559905
70PINK10.84131235
71KIT0.82078830
72TESK10.81473020
73IRAK30.81214255
74ERBB30.80119709
75WNK40.79149772
76PLK20.78906566
77ATR0.76830174
78IRAK40.76188220
79EPHA20.75921682
80BCR0.75323396
81BMPR20.75204342
82CSNK2A10.74693662
83CHEK20.74226852
84DYRK30.74029067
85TIE10.72212558
86YES10.71509524
87PBK0.70873598
88PAK30.70052903
89NEK20.68657149
90PRKCG0.68279486
91BMPR1B0.67109238
92MAP3K60.66525683
93PDK40.64047262
94PDK30.64047262
95ILK0.63185062
96IKBKB0.63110989
97MAPK130.62123166
98GRK50.61549442
99PRKCE0.60302992
100PIK3CG0.60077628
101GRK70.58978135
102MAP3K50.58003415
103CSNK2A20.56889440
104TBK10.55897627
105PRKCI0.55833076
106TESK20.53906326
107TEC0.53476853
108MAP3K110.53445755
109MAP2K60.52891744
110RAF10.52451312
111MAP2K30.51382659
112PAK10.51109240
113KDR0.51025137
114PRKCQ0.50471270
115TNIK0.49431311
116CAMK2A0.49390766
117DAPK10.48527421
118TLK10.47017867
119RPS6KL10.46427259
120RPS6KC10.46427259
121MAP3K40.46234416
122RPS6KA50.46062078
123PAK40.44797926
124PRKACA0.44690724
125RPS6KA60.44640650
126DAPK20.44547125
127ROCK10.44157674
128CAMK2D0.43929701
129CDK190.42507031
130CAMKK20.42205657
131ADRBK10.41342808
132ITK0.41244306
133STK40.40554253
134MAP2K70.40382027
135TAF10.39576502
136PKN10.39530093
137MAP3K30.39146305
138FLT30.39018763
139MAPK150.38256213
140PIM10.38036648
141ABL20.34465983
142CSNK1A10.34265685
143PRKCA0.34187654
144TAOK30.33020996
145SYK0.32248138

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.88972868
2Ribosome_Homo sapiens_hsa030104.12514220
3RNA polymerase_Homo sapiens_hsa030203.80321479
4Oxidative phosphorylation_Homo sapiens_hsa001903.66990804
5DNA replication_Homo sapiens_hsa030303.46863655
6Parkinsons disease_Homo sapiens_hsa050123.35621080
7Mismatch repair_Homo sapiens_hsa034302.94002650
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.70959784
9Pyrimidine metabolism_Homo sapiens_hsa002402.61470601
10Spliceosome_Homo sapiens_hsa030402.57288395
11Huntingtons disease_Homo sapiens_hsa050162.55272456
12Protein export_Homo sapiens_hsa030602.52031183
13Homologous recombination_Homo sapiens_hsa034402.48500845
14Base excision repair_Homo sapiens_hsa034102.46271092
15Nucleotide excision repair_Homo sapiens_hsa034202.34743085
16RNA transport_Homo sapiens_hsa030132.22689807
17Alzheimers disease_Homo sapiens_hsa050102.16129308
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.12418187
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08141336
20Basal transcription factors_Homo sapiens_hsa030221.92569031
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74776348
22RNA degradation_Homo sapiens_hsa030181.71429885
23Purine metabolism_Homo sapiens_hsa002301.65981160
24Cell cycle_Homo sapiens_hsa041101.63478486
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57072864
26Cardiac muscle contraction_Homo sapiens_hsa042601.52911678
27Non-homologous end-joining_Homo sapiens_hsa034501.50730049
28Fanconi anemia pathway_Homo sapiens_hsa034601.50230780
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32306157
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31440022
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28998363
32Butanoate metabolism_Homo sapiens_hsa006501.28333388
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20849737
34Tryptophan metabolism_Homo sapiens_hsa003801.18336450
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14116358
36Graft-versus-host disease_Homo sapiens_hsa053321.04239279
37Epstein-Barr virus infection_Homo sapiens_hsa051690.98575622
38Collecting duct acid secretion_Homo sapiens_hsa049660.98168381
39One carbon pool by folate_Homo sapiens_hsa006700.97764589
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93530105
41Sulfur metabolism_Homo sapiens_hsa009200.91278288
42Nitrogen metabolism_Homo sapiens_hsa009100.90838345
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89027430
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.87558639
45mRNA surveillance pathway_Homo sapiens_hsa030150.83952862
46Fatty acid degradation_Homo sapiens_hsa000710.82901302
47p53 signaling pathway_Homo sapiens_hsa041150.82136422
48Fructose and mannose metabolism_Homo sapiens_hsa000510.81804609
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78479910
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76898822
51Selenocompound metabolism_Homo sapiens_hsa004500.75111203
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74886902
53Glutathione metabolism_Homo sapiens_hsa004800.73621328
54Regulation of autophagy_Homo sapiens_hsa041400.72748075
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72582142
56Fatty acid metabolism_Homo sapiens_hsa012120.72497229
57Caffeine metabolism_Homo sapiens_hsa002320.70061502
58Steroid biosynthesis_Homo sapiens_hsa001000.69525405
59Carbon metabolism_Homo sapiens_hsa012000.68722826
60Galactose metabolism_Homo sapiens_hsa000520.66598862
61Chemical carcinogenesis_Homo sapiens_hsa052040.66352951
62Metabolic pathways_Homo sapiens_hsa011000.66313834
63Vibrio cholerae infection_Homo sapiens_hsa051100.66290972
64Folate biosynthesis_Homo sapiens_hsa007900.65760907
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.64935239
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63756175
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63601309
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63239632
69Arachidonic acid metabolism_Homo sapiens_hsa005900.60774384
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60639227
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59739780
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58773384
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57981422
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57947503
75beta-Alanine metabolism_Homo sapiens_hsa004100.57092528
76Biosynthesis of amino acids_Homo sapiens_hsa012300.57056207
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55404493
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50617334
79Pyruvate metabolism_Homo sapiens_hsa006200.48901311
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.48607665
81Legionellosis_Homo sapiens_hsa051340.48294002
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47396217
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47334572
84Oocyte meiosis_Homo sapiens_hsa041140.46840504
85N-Glycan biosynthesis_Homo sapiens_hsa005100.42876411
86Pentose phosphate pathway_Homo sapiens_hsa000300.42839210
87Rheumatoid arthritis_Homo sapiens_hsa053230.42001580
88Fatty acid elongation_Homo sapiens_hsa000620.41733819
89Ether lipid metabolism_Homo sapiens_hsa005650.40191848
90Fat digestion and absorption_Homo sapiens_hsa049750.38797593
91Vitamin B6 metabolism_Homo sapiens_hsa007500.36528762
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34475745
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34371868
94Retinol metabolism_Homo sapiens_hsa008300.34123017
95Phagosome_Homo sapiens_hsa041450.33563229
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32719404
97Allograft rejection_Homo sapiens_hsa053300.32712876
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.27934648
99Antigen processing and presentation_Homo sapiens_hsa046120.27123779
100Sulfur relay system_Homo sapiens_hsa041220.26712509
101Arginine and proline metabolism_Homo sapiens_hsa003300.26532736
102Herpes simplex infection_Homo sapiens_hsa051680.25759827
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.25236707
104Phenylalanine metabolism_Homo sapiens_hsa003600.25029310
105Asthma_Homo sapiens_hsa053100.23714509
106Tyrosine metabolism_Homo sapiens_hsa003500.22105623
107Autoimmune thyroid disease_Homo sapiens_hsa053200.20334229
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17693355
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16425767
110Thyroid cancer_Homo sapiens_hsa052160.16323745
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14761278
112Type I diabetes mellitus_Homo sapiens_hsa049400.13293587
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13202833
114Phototransduction_Homo sapiens_hsa047440.11390650
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11097087
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10613424
117Shigellosis_Homo sapiens_hsa051310.10106646
118HIF-1 signaling pathway_Homo sapiens_hsa040660.09786195
119Dilated cardiomyopathy_Homo sapiens_hsa054140.08736296
120Synaptic vesicle cycle_Homo sapiens_hsa047210.08320256
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.07057626
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.06972620
123Propanoate metabolism_Homo sapiens_hsa006400.06592638
124Other glycan degradation_Homo sapiens_hsa005110.06408917
125Viral carcinogenesis_Homo sapiens_hsa052030.06061035
126Linoleic acid metabolism_Homo sapiens_hsa005910.05504961
127HTLV-I infection_Homo sapiens_hsa051660.05338024
128Primary immunodeficiency_Homo sapiens_hsa053400.04305428
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.02284575
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.00793994
131Peroxisome_Homo sapiens_hsa041460.00710066

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