SPAG8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GTP biosynthetic process (GO:0006183)8.66359660
2ventricular system development (GO:0021591)8.56339422
3sperm motility (GO:0030317)8.35237263
4UTP biosynthetic process (GO:0006228)7.67491354
5nucleoside diphosphate phosphorylation (GO:0006165)7.55656123
6UTP metabolic process (GO:0046051)7.18079680
7fusion of sperm to egg plasma membrane (GO:0007342)7.00353324
8acrosome reaction (GO:0007340)6.93820472
9regulation of cilium movement (GO:0003352)6.84605884
10sperm-egg recognition (GO:0035036)6.53856346
11spermatid development (GO:0007286)6.22981660
12left/right axis specification (GO:0070986)6.15679028
13binding of sperm to zona pellucida (GO:0007339)6.11576760
14multicellular organism reproduction (GO:0032504)5.98214177
15CTP biosynthetic process (GO:0006241)5.96025762
16CTP metabolic process (GO:0046036)5.96025762
17intraciliary transport (GO:0042073)5.86161399
18cell wall macromolecule catabolic process (GO:0016998)5.82171031
19cell wall macromolecule metabolic process (GO:0044036)5.82171031
20cell-cell recognition (GO:0009988)5.71902085
21acrosome assembly (GO:0001675)5.70908305
22primary alcohol catabolic process (GO:0034310)5.70675127
23guanosine-containing compound biosynthetic process (GO:1901070)5.70161533
24cilium organization (GO:0044782)5.53699151
25pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)5.41544597
26regulation of inclusion body assembly (GO:0090083)5.35428090
27plasma membrane fusion (GO:0045026)5.31234732
28negative regulation of inclusion body assembly (GO:0090084)5.25082415
29pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)5.18607514
30cilium assembly (GO:0042384)5.18115667
31vitamin transmembrane transport (GO:0035461)4.98702624
32reproduction (GO:0000003)4.94217142
33single fertilization (GO:0007338)4.88775517
34ethanol metabolic process (GO:0006067)4.88637192
35microtubule bundle formation (GO:0001578)4.85830789
36synaptonemal complex organization (GO:0070193)4.70367631
37negative regulation of T cell differentiation in thymus (GO:0033085)4.67823781
38sperm capacitation (GO:0048240)4.62191930
39piRNA metabolic process (GO:0034587)4.57099201
40pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.54532898
41male meiosis (GO:0007140)4.52128139
42cellular component assembly involved in morphogenesis (GO:0010927)4.47855191
43diterpenoid biosynthetic process (GO:0016102)4.39259154
44left/right pattern formation (GO:0060972)4.38947846
45establishment or maintenance of monopolar cell polarity (GO:0061339)4.37388036
46establishment of monopolar cell polarity (GO:0061162)4.37388036
47fertilization (GO:0009566)4.32364971
48centriole assembly (GO:0098534)4.29646136
49establishment of apical/basal cell polarity (GO:0035089)4.27872762
50organic cation transport (GO:0015695)4.26484310
51spermatogenesis (GO:0007283)4.26436014
52male gamete generation (GO:0048232)4.24176277
53cilium morphogenesis (GO:0060271)4.22501015
54male meiosis I (GO:0007141)4.19296509
55tolerance induction (GO:0002507)4.14650509
56regulation of microtubule-based movement (GO:0060632)4.14271854
57microtubule-based movement (GO:0007018)4.13859649
58response to xenobiotic stimulus (GO:0009410)4.12198642
59pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.07718617
60microtubule severing (GO:0051013)3.96042138
61gamete generation (GO:0007276)3.88396255
62nucleotide phosphorylation (GO:0046939)3.87571643
63nucleoside diphosphate metabolic process (GO:0009132)3.77940984
64pyrimidine-containing compound transmembrane transport (GO:0072531)3.77858203
65negative regulation of B cell mediated immunity (GO:0002713)3.75062494
66negative regulation of immunoglobulin mediated immune response (GO:0002890)3.75062494
67synaptonemal complex assembly (GO:0007130)3.73886588
68ethanol oxidation (GO:0006069)3.71491225
69nonmotile primary cilium assembly (GO:0035058)3.66009345
70microtubule depolymerization (GO:0007019)3.63839093
71cell projection assembly (GO:0030031)3.58230575
72protein polyglutamylation (GO:0018095)3.57941801
73lateral ventricle development (GO:0021670)3.52521706
74retinoic acid metabolic process (GO:0042573)3.47251395
75terpenoid biosynthetic process (GO:0016114)3.46327760
76otic vesicle formation (GO:0030916)3.42275652
77protein localization to cilium (GO:0061512)3.35328550
78calcium ion-dependent exocytosis (GO:0017156)3.29247317
79cytoplasmic microtubule organization (GO:0031122)3.25576642
80germ cell development (GO:0007281)3.24700570
81microtubule polymerization or depolymerization (GO:0031109)3.17534671
82meiosis I (GO:0007127)3.16708587
83meiotic cell cycle (GO:0051321)3.15102612
84chaperone-mediated protein complex assembly (GO:0051131)3.14198508
85pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.14097087
86regulation of germinal center formation (GO:0002634)3.13843738
87establishment of planar polarity (GO:0001736)3.13152898
88establishment of tissue polarity (GO:0007164)3.13152898
89cell recognition (GO:0008037)3.12866931
90cellular process involved in reproduction in multicellular organism (GO:0022412)3.10993665
91regulation of interleukin-5 production (GO:0032674)3.09622961
92regulation of response to osmotic stress (GO:0047484)3.08549467
93multicellular organismal reproductive process (GO:0048609)3.08151548
94purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.07042009
95pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.04016336
96spermatid nucleus differentiation (GO:0007289)3.03771300
97determination of left/right symmetry (GO:0007368)3.03540476
98one-carbon compound transport (GO:0019755)3.03452227
99glomerular epithelial cell development (GO:0072310)3.02682060
100purine nucleoside triphosphate biosynthetic process (GO:0009145)3.01129370
101limb bud formation (GO:0060174)3.00474286
102negative regulation of humoral immune response (GO:0002921)2.99734504
103retinal rod cell development (GO:0046548)2.99707296
104aldehyde catabolic process (GO:0046185)2.98965956
105positive regulation of tolerance induction (GO:0002645)2.97953029
106centriole replication (GO:0007099)2.94902849
107lung epithelium development (GO:0060428)2.92875627
108exogenous drug catabolic process (GO:0042738)2.91197558
109determination of bilateral symmetry (GO:0009855)2.91051465
110protein refolding (GO:0042026)2.87646946
111brain morphogenesis (GO:0048854)2.87230570
112central nervous system myelination (GO:0022010)2.86142931
113axon ensheathment in central nervous system (GO:0032291)2.86142931
114specification of symmetry (GO:0009799)2.85342460
115pyrimidine ribonucleotide metabolic process (GO:0009218)2.82794142
116DNA methylation involved in gamete generation (GO:0043046)2.78748271
117microtubule-based process (GO:0007017)2.77770477
118positive regulation of smoothened signaling pathway (GO:0045880)2.76408829
119primary alcohol metabolic process (GO:0034308)2.74183641
120retinol metabolic process (GO:0042572)2.72616725
121photoreceptor cell differentiation (GO:0046530)2.72305985
122eye photoreceptor cell differentiation (GO:0001754)2.72305985
123glutathione derivative metabolic process (GO:1901685)2.67371831
124glutathione derivative biosynthetic process (GO:1901687)2.67371831
125organelle assembly (GO:0070925)2.67245172
126photoreceptor cell maintenance (GO:0045494)2.66753236
127multicellular organismal aging (GO:0010259)2.65667210
128ribonucleoside triphosphate biosynthetic process (GO:0009201)2.65529255
129nucleoside triphosphate biosynthetic process (GO:0009142)2.64018687
130phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.61760223
131substrate-independent telencephalic tangential migration (GO:0021826)2.60351076
132substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.60351076
133regulation of interleukin-13 production (GO:0032656)2.55174153
134ADP metabolic process (GO:0046031)2.54725986
135membrane repolarization during action potential (GO:0086011)2.54037734
136CDP-diacylglycerol biosynthetic process (GO:0016024)2.52533291
137cornea development in camera-type eye (GO:0061303)2.52090389
138smoothened signaling pathway (GO:0007224)2.50220732
139positive regulation of meiosis (GO:0045836)2.49648998
140heart looping (GO:0001947)2.47888481
141negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47300687
142regulation of smoothened signaling pathway (GO:0008589)2.45991021
143lateral sprouting from an epithelium (GO:0060601)2.45626510
144excretion (GO:0007588)2.44047370
145appendage development (GO:0048736)2.43950202
146limb development (GO:0060173)2.43950202
147membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.43262008
148neurotransmitter catabolic process (GO:0042135)2.42590398
149camera-type eye morphogenesis (GO:0048593)2.37797432
150CDP-diacylglycerol metabolic process (GO:0046341)2.36585961
151drug catabolic process (GO:0042737)2.36075535
152O-glycan processing (GO:0016266)2.33794858
153phenol-containing compound catabolic process (GO:0019336)2.33291546
154regulation of collateral sprouting (GO:0048670)2.32568667
155apical protein localization (GO:0045176)2.30694555
156cilium movement (GO:0003341)14.1373125
157axonemal dynein complex assembly (GO:0070286)13.5679224
158cilium or flagellum-dependent cell motility (GO:0001539)12.8338006
159epithelial cilium movement (GO:0003351)12.6878662
160axoneme assembly (GO:0035082)11.0982068
161epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.3666359
162motile cilium assembly (GO:0044458)10.1534564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.46933407
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.38382895
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.40480325
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.06468306
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93758462
6GATA1_26923725_Chip-Seq_HPCs_Mouse2.47740311
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.25518771
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18994949
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.15873656
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08084688
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03164759
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97344225
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.97045603
14STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83948283
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82743269
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.77709107
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.73516266
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.68157298
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.64066896
20REST_21632747_ChIP-Seq_MESCs_Mouse1.62407316
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60086349
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59083839
23SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.56176415
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.53126804
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48705160
26SMAD4_21799915_ChIP-Seq_A2780_Human1.48394071
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48229002
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45387016
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44986953
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44092758
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42850150
32P300_19829295_ChIP-Seq_ESCs_Human1.42557291
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42382717
34SMC4_20622854_ChIP-Seq_HELA_Human1.41446275
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41190222
36POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41190222
37CTCF_27219007_Chip-Seq_Bcells_Human1.40882979
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38989164
39DROSHA_22980978_ChIP-Seq_HELA_Human1.37428092
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.36535384
41STAT1_20625510_ChIP-Seq_HELA_Human1.36145029
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.36016864
43ZNF274_21170338_ChIP-Seq_K562_Hela1.35701736
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34452157
45CBP_20019798_ChIP-Seq_JUKART_Human1.34128709
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34128709
47TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33252874
48TDRD3_21172665_ChIP-Seq_MCF-7_Human1.32187814
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31574079
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30353602
51TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30219759
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29875925
53SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.29694086
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28453070
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.28234804
56RNF2_27304074_Chip-Seq_NSC_Mouse1.28093521
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26770471
58BCAT_22108803_ChIP-Seq_LS180_Human1.26325957
59SMAD4_21741376_ChIP-Seq_EPCs_Human1.25496396
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.25379853
61SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25358189
62CTCF_20526341_ChIP-Seq_ESCs_Human1.24542894
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24519590
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23841289
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23718184
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23234975
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.22771983
68TAF15_26573619_Chip-Seq_HEK293_Human1.19258055
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.18912467
70ETV1_20927104_ChIP-Seq_GIST48_Human1.18472503
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18428425
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17773390
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17634998
74FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17626108
75AHR_22903824_ChIP-Seq_MCF-7_Human1.17197313
76WDR5_24793694_ChIP-Seq_LNCAP_Human1.17162476
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16094765
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.16039749
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.15625177
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.15504534
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15428985
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14970367
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14851410
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14508714
85* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.14006600
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13983659
87VDR_22108803_ChIP-Seq_LS180_Human1.12363374
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12239910
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.11881090
90* TP63_22573176_ChIP-Seq_HFKS_Human1.11345959
91ER_23166858_ChIP-Seq_MCF-7_Human1.11259915
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.10346644
93* ELF1_20517297_ChIP-Seq_JURKAT_Human1.09371153
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09062839
95P68_20966046_ChIP-Seq_HELA_Human1.09054973
96PHF8_20622853_ChIP-Seq_HELA_Human1.09049740
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08971488
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07817170
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.07801085
100SMAD3_21741376_ChIP-Seq_ESCs_Human1.07050113
101SMRT_27268052_Chip-Seq_Bcells_Human1.06158068
102PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05658753
103FLI1_21867929_ChIP-Seq_TH2_Mouse1.05196808
104STAT1_17558387_ChIP-Seq_HELA_Human1.05118185
105KDM2B_26808549_Chip-Seq_REH_Human1.04432898
106EED_16625203_ChIP-ChIP_MESCs_Mouse1.04383365
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04302115
108* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03839150
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03052609
110* PHF8_20622854_ChIP-Seq_HELA_Human1.02215176
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01530582
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01525477
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01514580
114P53_22387025_ChIP-Seq_ESCs_Mouse1.01130267
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00361032
116RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00312920
117CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99863781
118TP63_23658742_ChIP-Seq_EP156T_Human0.99430023
119TCF4_22108803_ChIP-Seq_LS180_Human0.98697126
120HNFA_21074721_ChIP-Seq_CACO-2_Human0.98642700
121SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97035765
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.96806329
123NCOR_22424771_ChIP-Seq_293T_Human0.96547393
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96331183
125RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96313678
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96231389
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95971657
128RBPJ_21746931_ChIP-Seq_IB4_Human0.95734283
129MYC_19829295_ChIP-Seq_ESCs_Human0.95546264
130JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95363793
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95112543
132TBL1_22424771_ChIP-Seq_293T_Human0.94988217
133RUNX1_27514584_Chip-Seq_MCF-7_Human0.94865799
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94730760
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94583485
136POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94373837
137CRX_20693478_ChIP-Seq_RETINA_Mouse0.94127802
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93471401
139TCF4_23295773_ChIP-Seq_U87_Human0.93049470
140NANOG_20526341_ChIP-Seq_ESCs_Human0.92822994
141P300_18555785_Chip-Seq_ESCs_Mouse0.92673698
142SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92545728
143EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92060639
144P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91550574
145FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91245938
146FOXA1_25329375_ChIP-Seq_VCAP_Human0.91245938
147NFYA_21822215_ChIP-Seq_K562_Human0.91201189
148ERG_20517297_ChIP-Seq_VCAP_Human0.90108713
149TP53_18474530_ChIP-ChIP_U2OS_Human0.89995414
150CBX2_22325352_ChIP-Seq_293T-Rex_Human0.89755637
151KLF5_25053715_ChIP-Seq_YYC3_Human0.89420255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.69025406
2MP0008789_abnormal_olfactory_epithelium4.02554219
3MP0003698_abnormal_male_reproductive3.88537805
4MP0003136_yellow_coat_color3.87673579
5MP0002653_abnormal_ependyma_morphology3.45344037
6MP0001929_abnormal_gametogenesis3.44822742
7MP0000566_synostosis3.38313667
8MP0009379_abnormal_foot_pigmentation3.20072526
9MP0005394_taste/olfaction_phenotype3.12307225
10MP0005499_abnormal_olfactory_system3.12307225
11MP0004043_abnormal_pH_regulation3.01567398
12MP0005623_abnormal_meninges_morphology2.61158036
13MP0008004_abnormal_stomach_pH2.50492661
14MP0005646_abnormal_pituitary_gland2.47289891
15MP0003878_abnormal_ear_physiology2.34843692
16MP0005377_hearing/vestibular/ear_phenot2.34843692
17MP0006292_abnormal_olfactory_placode2.21938633
18MP0001984_abnormal_olfaction2.20028243
19MP0002282_abnormal_trachea_morphology2.17017741
20MP0002102_abnormal_ear_morphology2.14811654
21MP0009780_abnormal_chondrocyte_physiolo2.10365674
22MP0002161_abnormal_fertility/fecundity2.02008314
23MP0002210_abnormal_sex_determination1.99240863
24MP0002160_abnormal_reproductive_system1.94545885
25MP0003329_amyloid_beta_deposits1.93447595
26MP0001440_abnormal_grooming_behavior1.92490670
27MP0010030_abnormal_orbit_morphology1.89319630
28MP0004019_abnormal_vitamin_homeostasis1.87318580
29MP0004133_heterotaxia1.87004732
30MP0002638_abnormal_pupillary_reflex1.86990884
31MP0009046_muscle_twitch1.83667984
32MP0005083_abnormal_biliary_tract1.72314522
33MP0002822_catalepsy1.64272929
34MP0001293_anophthalmia1.62576867
35MP0004858_abnormal_nervous_system1.59296988
36MP0001145_abnormal_male_reproductive1.59161608
37MP0002736_abnormal_nociception_after1.58318256
38MP0004859_abnormal_synaptic_plasticity1.55023828
39MP0001485_abnormal_pinna_reflex1.54107974
40MP0001188_hyperpigmentation1.51059613
41MP0003011_delayed_dark_adaptation1.47951061
42MP0002928_abnormal_bile_duct1.46343543
43MP0002132_abnormal_respiratory_system1.45029108
44MP0002234_abnormal_pharynx_morphology1.42332975
45MP0000653_abnormal_sex_gland1.42213752
46MP0009250_abnormal_appendicular_skeleto1.39140104
47MP0008877_abnormal_DNA_methylation1.38507357
48MP0006072_abnormal_retinal_apoptosis1.37259502
49MP0002233_abnormal_nose_morphology1.36252766
50MP0003690_abnormal_glial_cell1.35745596
51MP0000049_abnormal_middle_ear1.34495562
52MP0005248_abnormal_Harderian_gland1.33528367
53MP0005423_abnormal_somatic_nervous1.32904140
54MP0000778_abnormal_nervous_system1.27308313
55MP0002572_abnormal_emotion/affect_behav1.25369092
56MP0003646_muscle_fatigue1.23777248
57MP0004885_abnormal_endolymph1.21755542
58MP0005551_abnormal_eye_electrophysiolog1.20808299
59MP0002168_other_aberrant_phenotype1.19163052
60MP0005670_abnormal_white_adipose1.18517481
61MP0002249_abnormal_larynx_morphology1.18043392
62MP0001968_abnormal_touch/_nociception1.17846623
63MP0006276_abnormal_autonomic_nervous1.17617017
64MP0003635_abnormal_synaptic_transmissio1.16686481
65MP0005379_endocrine/exocrine_gland_phen1.16674291
66MP0002557_abnormal_social/conspecific_i1.16509849
67MP0009745_abnormal_behavioral_response1.16011998
68MP0005389_reproductive_system_phenotype1.14949810
69MP0001486_abnormal_startle_reflex1.14106630
70MP0002064_seizures1.13939752
71MP0002735_abnormal_chemical_nociception1.12929487
72MP0005253_abnormal_eye_physiology1.11410403
73MP0000383_abnormal_hair_follicle1.11379800
74MP0002063_abnormal_learning/memory/cond1.07396112
75MP0001970_abnormal_pain_threshold1.06530660
76MP0001986_abnormal_taste_sensitivity1.06160536
77MP0001346_abnormal_lacrimal_gland1.05483721
78MP0002909_abnormal_adrenal_gland1.05465051
79MP0003634_abnormal_glial_cell1.01988939
80MP0001765_abnormal_ion_homeostasis0.99110808
81MP0002272_abnormal_nervous_system0.98474638
82MP0003938_abnormal_ear_development0.96568361
83MP0000678_abnormal_parathyroid_gland0.96179709
84MP0002734_abnormal_mechanical_nocicepti0.95530447
85MP0001963_abnormal_hearing_physiology0.92886167
86MP0009384_cardiac_valve_regurgitation0.92504543
87MP0000026_abnormal_inner_ear0.91196204
88MP0001270_distended_abdomen0.90690064
89MP0004270_analgesia0.89773222
90MP0000631_abnormal_neuroendocrine_gland0.87218842
91MP0001348_abnormal_lacrimal_gland0.86988206
92MP0003115_abnormal_respiratory_system0.86912891
93MP0008995_early_reproductive_senescence0.86794089
94MP0001529_abnormal_vocalization0.86553288
95MP0001905_abnormal_dopamine_level0.85839758
96MP0000604_amyloidosis0.85522586
97MP0003279_aneurysm0.85361961
98MP0001324_abnormal_eye_pigmentation0.84663998
99MP0003890_abnormal_embryonic-extraembry0.83887174
100MP0003122_maternal_imprinting0.83624353
101MP0005391_vision/eye_phenotype0.83279245
102MP0005636_abnormal_mineral_homeostasis0.82380239
103MP0003937_abnormal_limbs/digits/tail_de0.82162531
104MP0002882_abnormal_neuron_morphology0.80448645
105MP0002152_abnormal_brain_morphology0.79476187
106MP0002938_white_spotting0.79304629
107MP0002116_abnormal_craniofacial_bone0.79175299
108MP0002876_abnormal_thyroid_physiology0.77884051
109MP0005408_hypopigmentation0.77299899
110MP0004134_abnormal_chest_morphology0.76513760
111MP0003861_abnormal_nervous_system0.74846598
112MP0002067_abnormal_sensory_capabilities0.73323988
113MP0003283_abnormal_digestive_organ0.72565541
114MP0002733_abnormal_thermal_nociception0.72391870
115MP0004381_abnormal_hair_follicle0.71775145
116MP0000428_abnormal_craniofacial_morphol0.71290029
117MP0002277_abnormal_respiratory_mucosa0.71191427
118MP0005220_abnormal_exocrine_pancreas0.70156832
119MP0005395_other_phenotype0.69737135
120MP0001501_abnormal_sleep_pattern0.69640208
121MP0003880_abnormal_central_pattern0.69456772
122MP0001340_abnormal_eyelid_morphology0.69416923
123MP0003942_abnormal_urinary_system0.69100867
124MP0003787_abnormal_imprinting0.68954851
125MP0008872_abnormal_physiological_respon0.68890031
126MP0004142_abnormal_muscle_tone0.67458535
127MP0001851_eye_inflammation0.66584127
128MP0004742_abnormal_vestibular_system0.66500498
129MP0002092_abnormal_eye_morphology0.66313550
130MP0005195_abnormal_posterior_eye0.66004988
131MP0002229_neurodegeneration0.65691719
132MP0008875_abnormal_xenobiotic_pharmacok0.65669492
133MP0002752_abnormal_somatic_nervous0.65166556
134MP0005645_abnormal_hypothalamus_physiol0.64877444
135MP0010678_abnormal_skin_adnexa0.64834805
136MP0009053_abnormal_anal_canal0.64816655
137MP0005647_abnormal_sex_gland0.64149190
138MP0002254_reproductive_system_inflammat0.63988066
139MP0001502_abnormal_circadian_rhythm0.63987378
140MP0008569_lethality_at_weaning0.63842261
141MP0002295_abnormal_pulmonary_circulatio0.63292826
142MP0002184_abnormal_innervation0.63036569
143MP0000613_abnormal_salivary_gland0.61551481
144MP0000955_abnormal_spinal_cord0.61038609
145MP0002139_abnormal_hepatobiliary_system0.60325509

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.93118719
2Absent/shortened dynein arms (HP:0200106)9.85639125
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.85639125
4Abnormal respiratory motile cilium morphology (HP:0005938)9.59672242
5Abnormal respiratory epithelium morphology (HP:0012253)9.59672242
6Chronic bronchitis (HP:0004469)7.22996416
7Bronchiectasis (HP:0002110)5.49088293
8Nasal polyposis (HP:0100582)4.91392005
9Infertility (HP:0000789)4.23966811
10Nephronophthisis (HP:0000090)4.06426919
11Abnormality of the nasal mucosa (HP:0000433)3.99902894
12Chronic sinusitis (HP:0011109)3.87663461
13Bronchitis (HP:0012387)3.82164031
14True hermaphroditism (HP:0010459)3.74583649
15Pancreatic fibrosis (HP:0100732)3.61333953
16Medial flaring of the eyebrow (HP:0010747)3.20844676
17Tubulointerstitial nephritis (HP:0001970)3.20159774
18Recurrent sinusitis (HP:0011108)3.11542799
19Abnormality of the renal medulla (HP:0100957)3.06169434
20Abnormality of midbrain morphology (HP:0002418)2.92001203
21Molar tooth sign on MRI (HP:0002419)2.92001203
22Recurrent otitis media (HP:0000403)2.77903601
23Chronic otitis media (HP:0000389)2.74486195
24Congenital hepatic fibrosis (HP:0002612)2.62074113
25Postaxial foot polydactyly (HP:0001830)2.61786136
26Tubular atrophy (HP:0000092)2.60065229
27Gait imbalance (HP:0002141)2.58015337
28Pancreatic cysts (HP:0001737)2.53778154
29Congenital primary aphakia (HP:0007707)2.52770433
30Cystic liver disease (HP:0006706)2.49691517
31Abnormality of dentin (HP:0010299)2.47889744
32Median cleft lip (HP:0000161)2.47575575
33Supernumerary spleens (HP:0009799)2.47087323
34Occipital encephalocele (HP:0002085)2.41368196
35Tubulointerstitial abnormality (HP:0001969)2.37870284
36Hyperactive renin-angiotensin system (HP:0000841)2.35438155
37Abnormal biliary tract physiology (HP:0012439)2.30859762
38Bile duct proliferation (HP:0001408)2.30859762
39Abnormality of the dental root (HP:0006486)2.21229620
40Taurodontia (HP:0000679)2.21229620
41Abnormality of permanent molar morphology (HP:0011071)2.21229620
42Nephrogenic diabetes insipidus (HP:0009806)2.19483736
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.11972463
44Neurofibrillary tangles (HP:0002185)2.10599041
45Male infertility (HP:0003251)2.07730460
46Stage 5 chronic kidney disease (HP:0003774)2.06099397
47Abnormality of molar (HP:0011077)2.05549805
48Abnormality of molar morphology (HP:0011070)2.05549805
49Abnormality of the dental pulp (HP:0006479)2.04833263
50Fibular hypoplasia (HP:0003038)2.02034635
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9337343
52Abnormal respiratory motile cilium physiology (HP:0012261)11.4480500
53Abnormal ciliary motility (HP:0012262)10.4836408
54Postaxial hand polydactyly (HP:0001162)1.99683544
55Anencephaly (HP:0002323)1.98640921
56Aplasia/Hypoplasia of the spleen (HP:0010451)1.97352149
57Chronic hepatic failure (HP:0100626)1.96047882
58Asplenia (HP:0001746)1.95917374
59Abnormal drinking behavior (HP:0030082)1.88415344
60Polydipsia (HP:0001959)1.88415344
61Genital tract atresia (HP:0001827)1.85788649
62Poor coordination (HP:0002370)1.84153105
63Aplasia/Hypoplasia of the lens (HP:0008063)1.81248437
64Tubulointerstitial fibrosis (HP:0005576)1.79385574
65Preaxial hand polydactyly (HP:0001177)1.79237798
66Vaginal atresia (HP:0000148)1.78022839
67Oculomotor apraxia (HP:0000657)1.70219713
68Sclerocornea (HP:0000647)1.70108184
69Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69888134
70Facial cleft (HP:0002006)1.69315522
71Decreased circulating renin level (HP:0003351)1.67555497
72Concave nail (HP:0001598)1.67114420
73Polyphagia (HP:0002591)1.62776778
74Neonatal short-limb short stature (HP:0008921)1.59892578
75Male pseudohermaphroditism (HP:0000037)1.58976993
76Bell-shaped thorax (HP:0001591)1.58374782
77Recurrent bronchitis (HP:0002837)1.54942441
78Cerebral inclusion bodies (HP:0100314)1.52633295
79Broad distal phalanx of finger (HP:0009836)1.51101153
80Renal salt wasting (HP:0000127)1.49526108
81Nephropathy (HP:0000112)1.47985727
82Metaphyseal dysplasia (HP:0100255)1.46768676
83Absent frontal sinuses (HP:0002688)1.45016356
84Atelectasis (HP:0100750)1.44848582
85Abnormal rod and cone electroretinograms (HP:0008323)1.43946075
86Short nail (HP:0001799)1.43084900
87Abnormality of the renal cortex (HP:0011035)1.42608997
88Aplasia involving bones of the extremities (HP:0009825)1.41657865
89Aplasia involving bones of the upper limbs (HP:0009823)1.41657865
90Aplasia of the phalanges of the hand (HP:0009802)1.41657865
91Hyperkalemia (HP:0002153)1.39875210
92Neoplasm of head and neck (HP:0012288)1.39489499
93Esophageal neoplasm (HP:0100751)1.39489499
94Decreased central vision (HP:0007663)1.38279178
95Optic nerve coloboma (HP:0000588)1.33996237
96Megalencephaly (HP:0001355)1.32498996
97Sex reversal (HP:0012245)1.30879145
98Abnormal sex determination (HP:0012244)1.30879145
99Narrow forehead (HP:0000341)1.26949172
100Short ribs (HP:0000773)1.26638901
101Abnormality of renal excretion (HP:0011036)1.26366420
102Aganglionic megacolon (HP:0002251)1.26170407
103Rib fusion (HP:0000902)1.25971564
104Renal dysplasia (HP:0000110)1.25824146
105Bifid tongue (HP:0010297)1.25373300
106Multicystic kidney dysplasia (HP:0000003)1.25167047
107Furrowed tongue (HP:0000221)1.24949203
108Aplasia/Hypoplasia of the fibula (HP:0006492)1.24535355
109Gonadotropin excess (HP:0000837)1.23824071
11011 pairs of ribs (HP:0000878)1.23072662
111Short thorax (HP:0010306)1.22930346
112Broad foot (HP:0001769)1.22869326
113Hypodontia (HP:0000668)1.22591711
114Prominent nasal bridge (HP:0000426)1.21967355
115Specific learning disability (HP:0001328)1.20896744
116Hemiparesis (HP:0001269)1.20859300
117Abnormality of renin-angiotensin system (HP:0000847)1.20645919
118Hyperaldosteronism (HP:0000859)1.20421740
119Retinitis pigmentosa (HP:0000510)1.19986316
120Holoprosencephaly (HP:0001360)1.19350253
121Short femoral neck (HP:0100864)1.18746480
122Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.12456643
123Decreased testicular size (HP:0008734)1.09182341
124Aplasia/Hypoplasia of the sacrum (HP:0008517)1.08819036
125Anophthalmia (HP:0000528)1.07562196
126Abnormality of macular pigmentation (HP:0008002)1.07326097
127Fetal akinesia sequence (HP:0001989)1.07223809
128Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.06999068
129Abnormality of chloride homeostasis (HP:0011422)1.06326550
130Abnormality of the distal phalanges of the toes (HP:0010182)1.06308852
131Abnormality of the frontal sinuses (HP:0002687)1.06176285
132Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.02193115
133Left ventricular hypertrophy (HP:0001712)1.01285209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.01174263
2PDK45.42450537
3PDK35.42450537
4PNCK5.35330727
5TESK13.80797281
6STK163.80259430
7PDK23.44573164
8ICK3.39313049
9PRKD33.28165502
10EPHA23.07734944
11NTRK22.55786635
12PTK2B2.21497972
13WNK42.16087077
14LMTK22.05292801
15STK392.03427833
16STK241.75910582
17MAPKAPK31.67911702
18BMPR1B1.59611994
19DYRK31.55862456
20LRRK21.46570887
21PHKG21.31972990
22PHKG11.31972990
23DYRK1B1.21591458
24PIK3CG1.21235047
25PINK11.20620844
26IRAK11.19495545
27DAPK21.16791527
28MAP3K121.15471396
29CASK1.14859610
30TLK11.13829943
31SIK11.10691570
32WEE11.07432816
33MARK11.06038858
34STK381.05655073
35MUSK1.02982548
36MAP3K21.01513545
37CSK1.00518825
38PRKCG0.92026462
39TTK0.91025151
40NTRK30.84496791
41TYRO30.83048214
42PRKCI0.80805691
43ERBB20.80279951
44SMG10.79682189
45MST40.78812311
46GRK10.78444526
47DYRK1A0.76561567
48VRK10.76343377
49MAP3K70.76093594
50PLK20.75337573
51GRK50.73854776
52WNK30.73397372
53MAP4K20.72133477
54STK110.71684652
55NME10.70197394
56EPHA40.68991751
57BCR0.68106238
58EEF2K0.66826943
59NLK0.66433343
60CAMKK20.64871630
61TNIK0.64376951
62IRAK20.64292302
63ADRBK20.61630691
64MAPK130.60831035
65PASK0.60082473
66NEK60.58468696
67MAP2K70.57584851
68CDK30.57240725
69MAP2K20.57000284
70MAP3K60.54505531
71SGK10.54290936
72STK100.53867418
73TRPM70.53284652
74MINK10.52597944
75PDK10.52462058
76SGK2230.50179244
77SGK4940.50179244
78SIK20.49260092
79EPHA30.48953067
80MAP3K40.47333693
81MAP3K110.46102825
82PRKCD0.44207669
83RIPK40.44070184
84FGFR20.43497555
85CAMKK10.42565681
86WNK10.41193021
87ROCK10.40901441
88CAMK2G0.40897149
89RPS6KB20.40497638
90CDK50.40010411
91CAMK2A0.39274232
92MAP2K60.39251809
93GRK70.38138345
94PRKACA0.36444581
95AURKA0.35836618
96MAP3K30.35782618
97MOS0.35134179
98BRSK20.34786181
99PAK20.33979001
100ROCK20.33892448
101CDK190.33789691
102PAK30.33739826
103EPHB10.33699288
104SGK20.33552254
105ERBB30.33435143
106FGR0.33259795
107EPHB20.31655738
108INSRR0.30563429
109YES10.30402655
110MARK20.29659799
111SIK30.29497101
112PRKG10.29365467
113TIE10.29050822
114PRKCH0.28935158
115GSK3A0.27563688
116PRKAA20.27426065
117PRKCQ0.26794679
118TBK10.26326266
119PRKACG0.26238369
120CAMK2B0.25553871
121RPS6KA20.25454084
122HIPK20.25394868
123CAMK10.25270732
124BMPR20.25120304
125TGFBR10.24882769
126PDPK10.24633123
127OXSR10.24562696
128PAK10.24562207
129MAPKAPK50.24546130
130CDK80.23648284
131STK30.23264271
132ADRBK10.23210080
133GRK60.22374538
134FRK0.21931816
135DYRK20.20728988
136UHMK10.20033434
137PRKCE0.19749163
138PKN10.19517716
139MAPK100.19447005
140MAPK70.19207755
141PRKCA0.18507396
142PRKCZ0.17093555
143MAPK120.16604589
144MAP2K40.16150172

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.55949432
2Tyrosine metabolism_Homo sapiens_hsa003503.11324440
3Pyruvate metabolism_Homo sapiens_hsa006202.92137653
4beta-Alanine metabolism_Homo sapiens_hsa004102.82759538
5Fatty acid biosynthesis_Homo sapiens_hsa000612.80432757
6Huntingtons disease_Homo sapiens_hsa050162.80021598
7Vitamin B6 metabolism_Homo sapiens_hsa007502.51780031
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37236925
9Propanoate metabolism_Homo sapiens_hsa006402.34307774
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.21471017
11Amphetamine addiction_Homo sapiens_hsa050312.17174216
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.16422435
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.07111916
14PPAR signaling pathway_Homo sapiens_hsa033202.00484795
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.98871908
16Glucagon signaling pathway_Homo sapiens_hsa049221.85097726
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84149201
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78224810
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73512713
20Ribosome_Homo sapiens_hsa030101.67358763
21Linoleic acid metabolism_Homo sapiens_hsa005911.61592682
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60518250
23Nicotine addiction_Homo sapiens_hsa050331.59536444
24Dorso-ventral axis formation_Homo sapiens_hsa043201.55054085
25Ether lipid metabolism_Homo sapiens_hsa005651.54356909
26Hedgehog signaling pathway_Homo sapiens_hsa043401.52706661
27Renin secretion_Homo sapiens_hsa049241.52608864
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49450687
29Insulin secretion_Homo sapiens_hsa049111.42731737
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39263277
31Chemical carcinogenesis_Homo sapiens_hsa052041.38952242
32Cardiac muscle contraction_Homo sapiens_hsa042601.36094660
33Basal cell carcinoma_Homo sapiens_hsa052171.31303383
34Oxidative phosphorylation_Homo sapiens_hsa001901.29493676
35Fatty acid metabolism_Homo sapiens_hsa012121.28404939
36Cocaine addiction_Homo sapiens_hsa050301.27860915
37Glutathione metabolism_Homo sapiens_hsa004801.27431862
38Glycerolipid metabolism_Homo sapiens_hsa005611.27197829
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25211198
40Arachidonic acid metabolism_Homo sapiens_hsa005901.24386468
41Gastric acid secretion_Homo sapiens_hsa049711.23763793
42Circadian entrainment_Homo sapiens_hsa047131.22926979
43Fatty acid degradation_Homo sapiens_hsa000711.21811479
44Olfactory transduction_Homo sapiens_hsa047401.17657780
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.17502253
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.16104262
47Glutamatergic synapse_Homo sapiens_hsa047241.15039266
48Peroxisome_Homo sapiens_hsa041461.14962221
49Alzheimers disease_Homo sapiens_hsa050101.05755114
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05112778
51Mineral absorption_Homo sapiens_hsa049781.04217166
52Calcium signaling pathway_Homo sapiens_hsa040201.04122470
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03134481
54Fatty acid elongation_Homo sapiens_hsa000621.02501856
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01495528
56Circadian rhythm_Homo sapiens_hsa047101.00653714
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00073947
58Histidine metabolism_Homo sapiens_hsa003400.99255458
59Regulation of autophagy_Homo sapiens_hsa041400.98731372
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98501449
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97359236
62Salivary secretion_Homo sapiens_hsa049700.97298691
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.96576791
64Long-term potentiation_Homo sapiens_hsa047200.96306387
65Purine metabolism_Homo sapiens_hsa002300.95713976
66Basal transcription factors_Homo sapiens_hsa030220.94247913
67Notch signaling pathway_Homo sapiens_hsa043300.93457454
68Caffeine metabolism_Homo sapiens_hsa002320.92614974
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92347012
70Tight junction_Homo sapiens_hsa045300.91938013
71Thyroid hormone synthesis_Homo sapiens_hsa049180.88775443
72Butanoate metabolism_Homo sapiens_hsa006500.88021818
73Parkinsons disease_Homo sapiens_hsa050120.87928464
74cAMP signaling pathway_Homo sapiens_hsa040240.87318433
75GABAergic synapse_Homo sapiens_hsa047270.86885554
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85017680
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84131785
78Taste transduction_Homo sapiens_hsa047420.81489257
79Wnt signaling pathway_Homo sapiens_hsa043100.81037232
80Estrogen signaling pathway_Homo sapiens_hsa049150.80899864
81Bile secretion_Homo sapiens_hsa049760.80358758
82Axon guidance_Homo sapiens_hsa043600.76822472
83Phototransduction_Homo sapiens_hsa047440.76709084
84Collecting duct acid secretion_Homo sapiens_hsa049660.73579172
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73211545
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69300185
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68104998
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67994975
89Melanogenesis_Homo sapiens_hsa049160.67682822
90Protein export_Homo sapiens_hsa030600.67360066
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66583428
92Asthma_Homo sapiens_hsa053100.66068885
93Retinol metabolism_Homo sapiens_hsa008300.65518433
94Dopaminergic synapse_Homo sapiens_hsa047280.65411624
95Fructose and mannose metabolism_Homo sapiens_hsa000510.64499085
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.63745643
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.62964750
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62126316
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61918655
100Steroid biosynthesis_Homo sapiens_hsa001000.61129034
101Carbon metabolism_Homo sapiens_hsa012000.59783970
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59644927
103Synaptic vesicle cycle_Homo sapiens_hsa047210.59020050
104Alcoholism_Homo sapiens_hsa050340.57269474
105Oocyte meiosis_Homo sapiens_hsa041140.56802757
106Morphine addiction_Homo sapiens_hsa050320.56463604
107Metabolic pathways_Homo sapiens_hsa011000.56209506
108Starch and sucrose metabolism_Homo sapiens_hsa005000.55126178
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54198988
110Fat digestion and absorption_Homo sapiens_hsa049750.54166343
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.52461464
112Nitrogen metabolism_Homo sapiens_hsa009100.52249085
113Tryptophan metabolism_Homo sapiens_hsa003800.50850865
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50846997
115Sulfur metabolism_Homo sapiens_hsa009200.50741593
116Protein digestion and absorption_Homo sapiens_hsa049740.49566983
117Serotonergic synapse_Homo sapiens_hsa047260.49388517
118Selenocompound metabolism_Homo sapiens_hsa004500.49039028
119Sphingolipid metabolism_Homo sapiens_hsa006000.47754691
120Hippo signaling pathway_Homo sapiens_hsa043900.46802077
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45369522
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.44548202
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.43873303
124Vitamin digestion and absorption_Homo sapiens_hsa049770.43114599
125ABC transporters_Homo sapiens_hsa020100.42472260
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42442153
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41592434
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37361386
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36375640
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35479523
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35163487
132Ovarian steroidogenesis_Homo sapiens_hsa049130.35104788
133Type I diabetes mellitus_Homo sapiens_hsa049400.34398644
134Choline metabolism in cancer_Homo sapiens_hsa052310.29955048
135Oxytocin signaling pathway_Homo sapiens_hsa049210.29812530
136Autoimmune thyroid disease_Homo sapiens_hsa053200.29160762
137Allograft rejection_Homo sapiens_hsa053300.27961461
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.27481863
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.26528949
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24723318

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