SPAG9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.83567607
2synaptic vesicle maturation (GO:0016188)4.64427020
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.30792322
4layer formation in cerebral cortex (GO:0021819)4.07458718
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.04215126
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.94293205
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.87884193
8vocalization behavior (GO:0071625)3.81976741
9regulation of synaptic vesicle exocytosis (GO:2000300)3.72536575
10glutamate secretion (GO:0014047)3.67610327
11dendritic spine morphogenesis (GO:0060997)3.63484715
12regulation of glutamate receptor signaling pathway (GO:1900449)3.63083354
13synaptic vesicle exocytosis (GO:0016079)3.59853761
14dendrite morphogenesis (GO:0048813)3.58249282
15neuronal action potential propagation (GO:0019227)3.55319834
16regulation of synapse structural plasticity (GO:0051823)3.54344030
17pyrimidine nucleobase catabolic process (GO:0006208)3.47294853
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.45889642
19gamma-aminobutyric acid transport (GO:0015812)3.44161299
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.42374946
21exploration behavior (GO:0035640)3.42081694
22cellular potassium ion homeostasis (GO:0030007)3.41530077
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.41160879
24L-amino acid import (GO:0043092)3.37920104
25sodium ion export (GO:0071436)3.37831897
26neuron cell-cell adhesion (GO:0007158)3.36145753
27neurotransmitter secretion (GO:0007269)3.27131174
28central nervous system myelination (GO:0022010)3.24805329
29axon ensheathment in central nervous system (GO:0032291)3.24805329
30establishment of nucleus localization (GO:0040023)3.23437767
31protein localization to synapse (GO:0035418)3.22005665
32regulation of synaptic vesicle transport (GO:1902803)3.21775462
33regulation of NFAT protein import into nucleus (GO:0051532)3.18833606
34regulation of neuronal synaptic plasticity (GO:0048168)3.16504599
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.11807745
36proline transport (GO:0015824)3.10287803
37glutamate receptor signaling pathway (GO:0007215)3.09105248
38neurotransmitter-gated ion channel clustering (GO:0072578)3.08380555
39axonal fasciculation (GO:0007413)3.07392715
40neuron recognition (GO:0008038)3.02891330
41cerebellar Purkinje cell differentiation (GO:0021702)3.02352377
42activation of protein kinase A activity (GO:0034199)3.02034840
43synaptic transmission, glutamatergic (GO:0035249)2.96340308
44neuromuscular process controlling balance (GO:0050885)2.95523965
45negative regulation of neurotransmitter secretion (GO:0046929)2.94924789
46cerebral cortex radially oriented cell migration (GO:0021799)2.93990435
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93653186
48potassium ion import (GO:0010107)2.92466517
49regulation of dendritic spine morphogenesis (GO:0061001)2.92029388
50macroautophagy (GO:0016236)2.89561466
51regulation of fever generation (GO:0031620)2.87750151
52cerebellar granule cell differentiation (GO:0021707)2.86833508
53regulation of ARF protein signal transduction (GO:0032012)2.85016915
54central nervous system neuron axonogenesis (GO:0021955)2.84307381
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.84184442
56glycine transport (GO:0015816)2.83362882
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.82585034
58nerve growth factor signaling pathway (GO:0038180)2.81946445
59neuron-neuron synaptic transmission (GO:0007270)2.80699421
60cell communication by electrical coupling (GO:0010644)2.80695118
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.80592757
62long-term memory (GO:0007616)2.78419283
63vesicle transport along microtubule (GO:0047496)2.76250032
64neuronal stem cell maintenance (GO:0097150)2.75449150
65regulation of excitatory postsynaptic membrane potential (GO:0060079)2.74508104
66auditory behavior (GO:0031223)2.73986537
67Notch signaling involved in heart development (GO:0061314)2.73428692
68prepulse inhibition (GO:0060134)2.71879989
69amino acid import (GO:0043090)2.71487025
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71373497
71transmission of nerve impulse (GO:0019226)2.71340573
72astrocyte development (GO:0014002)2.67903753
73response to auditory stimulus (GO:0010996)2.67182376
74cell migration in hindbrain (GO:0021535)2.67120519
75establishment of mitochondrion localization (GO:0051654)2.66579109
76nucleobase catabolic process (GO:0046113)2.66262272
77regulation of postsynaptic membrane potential (GO:0060078)2.63715350
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.62879254
79neurotransmitter transport (GO:0006836)2.62760725
80alanine transport (GO:0032328)2.62756359
81regulation of synaptic transmission, glutamatergic (GO:0051966)2.61723888
82coronary vasculature morphogenesis (GO:0060977)2.61451074
83membrane depolarization during action potential (GO:0086010)2.59912861
84membrane assembly (GO:0071709)2.58622493
85negative regulation of neurotransmitter transport (GO:0051589)2.57699475
86regulation of dendritic spine development (GO:0060998)2.55087333
87long-term synaptic potentiation (GO:0060291)2.54744445
88clathrin coat assembly (GO:0048268)2.54326151
89regulation of axon guidance (GO:1902667)2.54142242
90axon extension (GO:0048675)2.53640802
91negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.53585072
92regulation of neurotransmitter secretion (GO:0046928)2.53440692
93neuronal ion channel clustering (GO:0045161)2.52818383
94regulation of synaptic plasticity (GO:0048167)2.51628313
95synaptic vesicle endocytosis (GO:0048488)2.51109089
96cytoskeletal anchoring at plasma membrane (GO:0007016)2.50188369
97nucleus localization (GO:0051647)2.48336528
98organelle transport along microtubule (GO:0072384)2.47736740
99positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.47666694
100cerebral cortex cell migration (GO:0021795)2.47152400
101regulation of axon extension involved in axon guidance (GO:0048841)2.46520596
102regulation of voltage-gated calcium channel activity (GO:1901385)2.46326491
103response to lipoprotein particle (GO:0055094)2.45335893
104suckling behavior (GO:0001967)2.45167214
105positive regulation of membrane potential (GO:0045838)2.44950043
106G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44026026
107potassium ion homeostasis (GO:0055075)2.43533350
108mating behavior (GO:0007617)2.43102496
109central nervous system projection neuron axonogenesis (GO:0021952)2.42441893
110regulation of heat generation (GO:0031650)2.41932327
111regulation of neurotransmitter levels (GO:0001505)2.41640549
112synapse organization (GO:0050808)2.40758854
113negative regulation of oligodendrocyte differentiation (GO:0048715)2.40332790
114innervation (GO:0060384)2.40304849
115membrane depolarization (GO:0051899)2.39953183
116dendritic spine organization (GO:0097061)2.38949143
117presynaptic membrane assembly (GO:0097105)2.38162504
118cellular sodium ion homeostasis (GO:0006883)2.37965496
119regulation of clathrin-mediated endocytosis (GO:2000369)2.37944518
120adult walking behavior (GO:0007628)2.37196513
121photoreceptor cell differentiation (GO:0046530)2.36746760
122eye photoreceptor cell differentiation (GO:0001754)2.36746760
123regulation of neurotransmitter transport (GO:0051588)2.36102525
124gamma-aminobutyric acid signaling pathway (GO:0007214)2.35666579
125positive regulation of potassium ion transmembrane transport (GO:1901381)2.34926895
126cytoplasmic mRNA processing body assembly (GO:0033962)2.34510413
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.34078436
128presynaptic membrane organization (GO:0097090)2.33977326
129postsynaptic membrane organization (GO:0001941)2.33904491
130negative regulation of dendrite morphogenesis (GO:0050774)2.33836330
131neuron projection extension involved in neuron projection guidance (GO:1902284)2.29330672
132axon extension involved in axon guidance (GO:0048846)2.29330672
133neuron projection extension (GO:1990138)2.29063128
134myelination (GO:0042552)2.28664923
135embryonic retina morphogenesis in camera-type eye (GO:0060059)2.28235623
136apical protein localization (GO:0045176)2.26625495
137negative regulation of dendrite development (GO:2000171)2.26059685
138regulation of respiratory system process (GO:0044065)2.24182787
139axonogenesis (GO:0007409)2.22953105
140ensheathment of neurons (GO:0007272)2.21617198
141axon ensheathment (GO:0008366)2.21617198
142camera-type eye morphogenesis (GO:0048593)2.21007866
143negative regulation of vascular permeability (GO:0043116)2.20445389
144asymmetric protein localization (GO:0008105)2.19210356
145astrocyte differentiation (GO:0048708)2.18793121
146negative regulation of inclusion body assembly (GO:0090084)2.17926334
147synapse assembly (GO:0007416)2.17494882
148positive regulation of dendritic spine morphogenesis (GO:0061003)2.17483359
149cerebral cortex neuron differentiation (GO:0021895)2.16702979
150limb bud formation (GO:0060174)2.16437178
151dermatan sulfate biosynthetic process (GO:0030208)2.16389774
152regulation of dendrite morphogenesis (GO:0048814)2.14852239
153startle response (GO:0001964)2.14623004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.12273379
2GBX2_23144817_ChIP-Seq_PC3_Human2.95372758
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61892827
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56176443
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42746017
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39051653
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39051653
8* DROSHA_22980978_ChIP-Seq_HELA_Human2.22829091
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19583974
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17696118
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17433893
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16707655
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10347723
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08433186
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.05943641
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04941726
17AR_21572438_ChIP-Seq_LNCaP_Human2.04179896
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.96083859
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.91344073
20RARB_27405468_Chip-Seq_BRAIN_Mouse1.89874587
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.85647474
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83682185
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83681182
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80633567
25REST_21632747_ChIP-Seq_MESCs_Mouse1.78816338
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72418627
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.62521402
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57416596
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.53579364
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53304744
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52740137
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52019806
33SMAD4_21799915_ChIP-Seq_A2780_Human1.49150733
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48111336
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46840862
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.40505378
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38553507
38* REST_18959480_ChIP-ChIP_MESCs_Mouse1.38280300
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37023446
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36271208
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35994134
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.35866077
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34622022
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34135859
45WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32454990
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31776269
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31487133
48IGF1R_20145208_ChIP-Seq_DFB_Human1.30455250
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29830040
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.29499964
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29185432
52AHR_22903824_ChIP-Seq_MCF-7_Human1.28942987
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27654946
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27385939
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27358366
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.27019550
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25847682
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25480173
59STAT3_23295773_ChIP-Seq_U87_Human1.22380667
60STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21595045
61CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21559522
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20902009
63TAF15_26573619_Chip-Seq_HEK293_Human1.20749659
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.20415277
65LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18803004
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17965307
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17645191
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17565932
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.17334481
70KDM2B_26808549_Chip-Seq_K562_Human1.17279237
71AR_19668381_ChIP-Seq_PC3_Human1.16974872
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.16801972
73CJUN_26792858_Chip-Seq_BT549_Human1.16212567
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16145960
75* TP53_16413492_ChIP-PET_HCT116_Human1.15858070
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15819475
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15770495
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15770495
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15358401
80AR_25329375_ChIP-Seq_VCAP_Human1.14931213
81P300_19829295_ChIP-Seq_ESCs_Human1.14574493
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.14113774
83* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12761443
84* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12024400
85ZNF274_21170338_ChIP-Seq_K562_Hela1.11859893
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11778147
87RXR_22108803_ChIP-Seq_LS180_Human1.11396507
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10845848
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09891856
90FUS_26573619_Chip-Seq_HEK293_Human1.09641842
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.08546493
92RNF2_27304074_Chip-Seq_NSC_Mouse1.07916383
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07807507
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04937969
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04578652
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03741659
97ISL1_27105846_Chip-Seq_CPCs_Mouse1.03623687
98ESR1_20079471_ChIP-ChIP_T-47D_Human1.03520161
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03413256
100* TCF4_23295773_ChIP-Seq_U87_Human1.02984865
101SOX9_26525672_Chip-Seq_HEART_Mouse1.02405884
102SMAD4_21741376_ChIP-Seq_HESCs_Human1.02178582
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01931094
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.01472105
105KDM2B_26808549_Chip-Seq_REH_Human1.00637614
106* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00140547
107CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99019927
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.96868203
109TRIM28_21343339_ChIP-Seq_HEK293_Human0.96183187
110TP53_18474530_ChIP-ChIP_U2OS_Human0.96064959
111P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95743621
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94918445
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94918445
114BCAT_22108803_ChIP-Seq_LS180_Human0.94004200
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93609986
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92659763
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91143561
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.90940719
119ER_23166858_ChIP-Seq_MCF-7_Human0.89859813
120ESR2_21235772_ChIP-Seq_MCF-7_Human0.89536413
121* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88828316
122RUNX2_22187159_ChIP-Seq_PCA_Human0.88659139
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87077163
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87063224
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86673880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.65000963
2MP0003635_abnormal_synaptic_transmissio3.52741695
3MP0003880_abnormal_central_pattern3.46189742
4MP0004270_analgesia3.44530793
5MP0009046_muscle_twitch2.99425396
6MP0002063_abnormal_learning/memory/cond2.76320401
7MP0009745_abnormal_behavioral_response2.73781637
8MP0002064_seizures2.69453756
9MP0005423_abnormal_somatic_nervous2.61905080
10MP0000569_abnormal_digit_pigmentation2.58967937
11MP0009780_abnormal_chondrocyte_physiolo2.52954993
12MP0001486_abnormal_startle_reflex2.41281674
13MP0001968_abnormal_touch/_nociception2.26972930
14MP0002734_abnormal_mechanical_nocicepti2.24607357
15MP0002572_abnormal_emotion/affect_behav2.24437972
16MP0002272_abnormal_nervous_system2.16507828
17MP0000778_abnormal_nervous_system2.12973246
18MP0003136_yellow_coat_color1.98053077
19MP0008569_lethality_at_weaning1.95744229
20MP0004858_abnormal_nervous_system1.95686653
21MP0001440_abnormal_grooming_behavior1.91457719
22MP0004885_abnormal_endolymph1.91035028
23MP0000751_myopathy1.86969884
24MP0003690_abnormal_glial_cell1.84700799
25MP0003329_amyloid_beta_deposits1.84474820
26MP0002067_abnormal_sensory_capabilities1.82734268
27MP0000920_abnormal_myelination1.71912915
28MP0005248_abnormal_Harderian_gland1.70120625
29MP0001501_abnormal_sleep_pattern1.67305644
30MP0002822_catalepsy1.66644221
31MP0005409_darkened_coat_color1.63650891
32MP0002909_abnormal_adrenal_gland1.62922965
33MP0004811_abnormal_neuron_physiology1.62610889
34MP0002733_abnormal_thermal_nociception1.61095654
35MP0005623_abnormal_meninges_morphology1.57431221
36MP0000955_abnormal_spinal_cord1.57185292
37MP0002184_abnormal_innervation1.56154626
38MP0002736_abnormal_nociception_after1.54180217
39MP0004145_abnormal_muscle_electrophysio1.52727366
40MP0003705_abnormal_hypodermis_morpholog1.52225826
41MP0005386_behavior/neurological_phenoty1.51136434
42MP0004924_abnormal_behavior1.51136434
43MP0001970_abnormal_pain_threshold1.50283990
44MP0003633_abnormal_nervous_system1.49516285
45MP0001299_abnormal_eye_distance/1.49194041
46MP0002557_abnormal_social/conspecific_i1.46633392
47MP0003634_abnormal_glial_cell1.46203726
48MP0002735_abnormal_chemical_nociception1.46168570
49MP0002638_abnormal_pupillary_reflex1.39492954
50MP0005646_abnormal_pituitary_gland1.37406260
51MP0002882_abnormal_neuron_morphology1.35970869
52MP0004130_abnormal_muscle_cell1.33746300
53MP0002066_abnormal_motor_capabilities/c1.29218469
54MP0003631_nervous_system_phenotype1.28469604
55MP0003122_maternal_imprinting1.21465133
56MP0000566_synostosis1.19386705
57MP0002332_abnormal_exercise_endurance1.17397322
58MP0001502_abnormal_circadian_rhythm1.17242039
59MP0000383_abnormal_hair_follicle1.15155421
60MP0003632_abnormal_nervous_system1.13377750
61MP0010678_abnormal_skin_adnexa1.12625918
62MP0001177_atelectasis1.12095531
63MP0000013_abnormal_adipose_tissue1.11816926
64MP0008961_abnormal_basal_metabolism1.11014144
65MP0005076_abnormal_cell_differentiation1.10886446
66MP0000604_amyloidosis1.10539768
67MP0002152_abnormal_brain_morphology1.09352096
68MP0003045_fibrosis1.08014669
69MP0004742_abnormal_vestibular_system1.07732462
70MP0000733_abnormal_muscle_development1.07212827
71MP0003303_peritoneal_inflammation1.06875343
72MP0005645_abnormal_hypothalamus_physiol1.06164939
73MP0003787_abnormal_imprinting1.05662058
74MP0002877_abnormal_melanocyte_morpholog1.05267549
75MP0004215_abnormal_myocardial_fiber1.04772030
76MP0002896_abnormal_bone_mineralization1.04595408
77MP0000579_abnormal_nail_morphology1.04255035
78MP0000534_abnormal_ureter_morphology1.01819442
79MP0002090_abnormal_vision1.00226776
80MP0005257_abnormal_intraocular_pressure0.99417314
81MP0010352_gastrointestinal_tract_polyps0.98966780
82MP0001984_abnormal_olfaction0.97948349
83MP0004142_abnormal_muscle_tone0.97569477
84MP0005167_abnormal_blood-brain_barrier0.95771466
85MP0000747_muscle_weakness0.95032928
86MP0000647_abnormal_sebaceous_gland0.94655300
87MP0004085_abnormal_heartbeat0.94019814
88MP0000428_abnormal_craniofacial_morphol0.94000777
89MP0006054_spinal_hemorrhage0.93114584
90MP0002229_neurodegeneration0.92208638
91MP0003385_abnormal_body_wall0.89448264
92MP0002092_abnormal_eye_morphology0.89419988
93MP0006276_abnormal_autonomic_nervous0.88192478
94MP0003935_abnormal_craniofacial_develop0.87054863
95MP0003950_abnormal_plasma_membrane0.85341286
96MP0003183_abnormal_peptide_metabolism0.84958197
97MP0003755_abnormal_palate_morphology0.82199434
98MP0002837_dystrophic_cardiac_calcinosis0.82029268
99MP0003879_abnormal_hair_cell0.81789822
100MP0003137_abnormal_impulse_conducting0.81360917
101MP0005187_abnormal_penis_morphology0.81059520
102MP0004233_abnormal_muscle_weight0.80476442
103MP0002009_preneoplasia0.80300266
104MP0005551_abnormal_eye_electrophysiolog0.80141941
105MP0000026_abnormal_inner_ear0.79897598
106MP0004510_myositis0.79701413
107MP0003075_altered_response_to0.78743492
108MP0003221_abnormal_cardiomyocyte_apopto0.78449283
109MP0004036_abnormal_muscle_relaxation0.77898451
110MP0003283_abnormal_digestive_organ0.77205573
111MP0002081_perinatal_lethality0.76363973
112MP0001958_emphysema0.76362272
113MP0004484_altered_response_of0.74995801
114MP0005595_abnormal_vascular_smooth0.74583947
115MP0005620_abnormal_muscle_contractility0.74333801
116MP0003091_abnormal_cell_migration0.74040176
117MP0002069_abnormal_eating/drinking_beha0.73796421
118MP0000537_abnormal_urethra_morphology0.72883072
119MP0005171_absent_coat_pigmentation0.72035469
120MP0004087_abnormal_muscle_fiber0.71265951
121MP0005391_vision/eye_phenotype0.70826344
122MP0001915_intracranial_hemorrhage0.70767397
123MP0003115_abnormal_respiratory_system0.70406787
124MP0002697_abnormal_eye_size0.70009147
125MP0002108_abnormal_muscle_morphology0.69668618
126MP0008874_decreased_physiological_sensi0.68793658
127MP0003172_abnormal_lysosome_physiology0.68363119
128MP0003937_abnormal_limbs/digits/tail_de0.68068527
129MP0005535_abnormal_body_temperature0.66273734
130MP0001943_abnormal_respiration0.65315478
131MP0004084_abnormal_cardiac_muscle0.63688368
132MP0003300_gastrointestinal_ulcer0.62861540
133MP0004272_abnormal_basement_membrane0.62267886
134MP0002752_abnormal_somatic_nervous0.62030839
135MP0000003_abnormal_adipose_tissue0.58632574
136MP0001963_abnormal_hearing_physiology0.58393868
137MP0003861_abnormal_nervous_system0.57540332
138MP0000759_abnormal_skeletal_muscle0.57359380

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.67520085
2Myokymia (HP:0002411)4.51243235
3Action tremor (HP:0002345)4.48612450
4Focal seizures (HP:0007359)4.06190088
5Termporal pattern (HP:0011008)3.58132442
6Insidious onset (HP:0003587)3.58132442
7Progressive cerebellar ataxia (HP:0002073)3.52354951
8Supranuclear gaze palsy (HP:0000605)3.40378824
9Epileptic encephalopathy (HP:0200134)3.13374374
10Visual hallucinations (HP:0002367)3.11297220
11Ankle clonus (HP:0011448)3.07081414
12Urinary bladder sphincter dysfunction (HP:0002839)2.87945184
13Neurofibrillary tangles (HP:0002185)2.86048965
14Atonic seizures (HP:0010819)2.84630942
15Genetic anticipation (HP:0003743)2.81966990
16Dysdiadochokinesis (HP:0002075)2.78934079
17Megalencephaly (HP:0001355)2.76941795
18Papillary thyroid carcinoma (HP:0002895)2.75809481
19Urinary urgency (HP:0000012)2.74368937
20Febrile seizures (HP:0002373)2.69488809
21Broad-based gait (HP:0002136)2.68265765
22Impaired vibration sensation in the lower limbs (HP:0002166)2.67536160
23Intention tremor (HP:0002080)2.66311930
24Abnormality of the corticospinal tract (HP:0002492)2.66101022
25Absence seizures (HP:0002121)2.61005075
26Dysmetria (HP:0001310)2.60647599
27Postural instability (HP:0002172)2.59536337
28Cerebral inclusion bodies (HP:0100314)2.58906975
29Generalized tonic-clonic seizures (HP:0002069)2.56295212
30Hemiplegia (HP:0002301)2.56065614
31Gaze-evoked nystagmus (HP:0000640)2.55414972
32Truncal ataxia (HP:0002078)2.53578751
33Depression (HP:0000716)2.48456575
34Drooling (HP:0002307)2.42832193
35Excessive salivation (HP:0003781)2.42832193
36Scanning speech (HP:0002168)2.41767391
37Macroorchidism (HP:0000053)2.38158777
38Dysmetric saccades (HP:0000641)2.36342926
39Dialeptic seizures (HP:0011146)2.35961504
40Lower limb muscle weakness (HP:0007340)2.34777229
41Abnormal social behavior (HP:0012433)2.33476591
42Impaired social interactions (HP:0000735)2.33476591
43Onion bulb formation (HP:0003383)2.33414792
44Lower limb amyotrophy (HP:0007210)2.33390795
45Poor eye contact (HP:0000817)2.31953520
46Hemiparesis (HP:0001269)2.31453582
47Vertebral arch anomaly (HP:0008438)2.31004953
48Spastic gait (HP:0002064)2.30016718
49Difficulty running (HP:0009046)2.30009614
50Heterotopia (HP:0002282)2.29736021
51Papilledema (HP:0001085)2.28553300
52Aplasia involving bones of the extremities (HP:0009825)2.27331031
53Aplasia involving bones of the upper limbs (HP:0009823)2.27331031
54Aplasia of the phalanges of the hand (HP:0009802)2.27331031
55Mutism (HP:0002300)2.24725229
56Diplopia (HP:0000651)2.19464978
57Abnormality of binocular vision (HP:0011514)2.19464978
58Cortical dysplasia (HP:0002539)2.18121769
59Abnormal eating behavior (HP:0100738)2.16199034
60Large earlobe (HP:0009748)2.13149965
61Abnormality of the ischium (HP:0003174)2.13013337
62Disinhibition (HP:0000734)2.13010939
63Postural tremor (HP:0002174)2.08514721
64Hyperventilation (HP:0002883)2.08364969
65Hammertoe (HP:0001765)2.07634396
66Pheochromocytoma (HP:0002666)2.07566039
67Aqueductal stenosis (HP:0002410)2.06979224
68Neonatal short-limb short stature (HP:0008921)2.02985550
69Anxiety (HP:0000739)2.02656594
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02626070
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.02626070
72Ulnar claw (HP:0001178)2.01491653
73Torticollis (HP:0000473)1.99724663
74Progressive inability to walk (HP:0002505)1.99174288
75Renovascular hypertension (HP:0100817)1.98640797
76Apathy (HP:0000741)1.97276551
77Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95531229
78Exotropia (HP:0000577)1.94874083
79Hyperacusis (HP:0010780)1.94558866
80Exercise-induced myalgia (HP:0003738)1.94382290
81Neuroendocrine neoplasm (HP:0100634)1.91055551
82Peripheral hypomyelination (HP:0007182)1.90833350
83Bundle branch block (HP:0011710)1.90583791
84Abnormality of the diencephalon (HP:0010662)1.89851043
85Hepatoblastoma (HP:0002884)1.88869396
86Bronchomalacia (HP:0002780)1.88384725
87Alacrima (HP:0000522)1.88099704
88Abnormality of the lower motor neuron (HP:0002366)1.86147553
89Short 4th metacarpal (HP:0010044)1.85329426
90Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85329426
91Impaired smooth pursuit (HP:0007772)1.85132094
92Broad metatarsal (HP:0001783)1.84667756
93Spastic tetraparesis (HP:0001285)1.83019619
94Pointed chin (HP:0000307)1.82024680
95Impaired vibratory sensation (HP:0002495)1.81382410
96Cutaneous finger syndactyly (HP:0010554)1.79797554
97Agitation (HP:0000713)1.79482928
98Tracheomalacia (HP:0002779)1.79142674
99Amblyopia (HP:0000646)1.78435764
100Arterial tortuosity (HP:0005116)1.77506071
101Decreased lacrimation (HP:0000633)1.77423037
102Stereotypic behavior (HP:0000733)1.77347603
103Elfin facies (HP:0004428)1.77154406
104Missing ribs (HP:0000921)1.76901521
105Split foot (HP:0001839)1.76900089
106Neuronal loss in central nervous system (HP:0002529)1.76575553
107Overriding aorta (HP:0002623)1.75226038
108Insomnia (HP:0100785)1.74918383
109Abnormality of ocular smooth pursuit (HP:0000617)1.74594597
110Hypoplasia of the corpus callosum (HP:0002079)1.74406761
111Cubitus valgus (HP:0002967)1.73973083
112Frequent falls (HP:0002359)1.72862879
113Spastic paraplegia (HP:0001258)1.72270008
114Blue irides (HP:0000635)1.72268069
115Hypoplasia of the iris (HP:0007676)1.72102830
116Prolonged QT interval (HP:0001657)1.71702219
117Hyporeflexia of lower limbs (HP:0002600)1.71199240
118Buphthalmos (HP:0000557)1.70085421
119Decreased motor nerve conduction velocity (HP:0003431)1.69219243
120Neoplasm of the heart (HP:0100544)1.68854475
121Diminished motivation (HP:0000745)1.68836814
122Subacute progressive viral hepatitis (HP:0006572)1.67438772
123Increased variability in muscle fiber diameter (HP:0003557)1.66026768
124Bradykinesia (HP:0002067)1.65345323
125Clonus (HP:0002169)1.64993128
126Open mouth (HP:0000194)1.64779934
127Inappropriate behavior (HP:0000719)1.64527561
128Thickened helices (HP:0000391)1.63775188
129Laryngomalacia (HP:0001601)1.63240784
130Abnormality of the 4th metacarpal (HP:0010012)1.62966320
131Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62865446
132Steppage gait (HP:0003376)1.62822313
133Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.62573839
134Abnormality of salivation (HP:0100755)1.62515529
135Absent speech (HP:0001344)1.62430428
136Wide anterior fontanel (HP:0000260)1.61867008
137Turricephaly (HP:0000262)1.61499717
138Abnormality of the distal phalanx of the thumb (HP:0009617)1.61496185
139Resting tremor (HP:0002322)1.61424284
140Rapidly progressive (HP:0003678)1.61395487
141Abnormality of saccadic eye movements (HP:0000570)1.61169697
142Focal dystonia (HP:0004373)1.61006533
143Absent frontal sinuses (HP:0002688)1.60231249
144Overgrowth (HP:0001548)1.60116161
145Pulmonic stenosis (HP:0001642)1.60082747
146Tibial bowing (HP:0002982)1.58717565
147Thyroid carcinoma (HP:0002890)1.58486204
148Vascular tortuosity (HP:0004948)1.58016710
149Paraplegia (HP:0010550)1.56654580
150Flat cornea (HP:0007720)1.52922692
151Fibular hypoplasia (HP:0003038)1.52734913

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.49329138
2NTRK33.22473579
3EPHA42.95029793
4MAP3K92.93822126
5MAP3K42.36239054
6EPHA32.35914279
7PAK62.26232786
8NTRK22.20231813
9DAPK22.08500331
10MINK11.93527523
11PHKG21.87228330
12PHKG11.87228330
13NTRK11.81477828
14BRD41.79882732
15PRKD31.78364824
16KSR21.76917781
17CAMKK11.71203312
18CAMK1G1.67198003
19MAP2K41.54311431
20KSR11.51712146
21BCR1.44979819
22MAP2K71.44895397
23TYRO31.44083181
24CDK51.42819279
25FGFR21.39259991
26SGK2231.34657293
27SGK4941.34657293
28RIPK11.33726195
29WNK11.30507470
30EPHB21.30453230
31AKT31.22411332
32LMTK21.20448480
33LATS11.20344251
34MAP3K21.19537291
35RET1.17445907
36SIK21.17375439
37MAPK151.16589593
38STK381.16153660
39TRIB31.15812449
40PDGFRA1.14109470
41PAK31.12663516
42SGK31.12073998
43TNIK1.11885315
44IRAK31.09837442
45CAMK1D1.09667491
46CAMKK21.07034860
47SGK21.06156287
48MAPK131.05803998
49DMPK1.04784500
50PRKCH1.04216411
51UHMK11.04210706
52RIPK41.02932654
53MET1.02645659
54MOS1.02209246
55CASK0.98226207
56STK110.97031133
57STK390.96644477
58PLK20.95146933
59OXSR10.94772986
60PNCK0.93163125
61STK38L0.92957989
62PRPF4B0.92196860
63DDR20.92147581
64MAP3K60.89752566
65FGFR30.88786902
66SGK10.88370910
67MAP3K130.87372855
68PKN10.86994675
69CDK120.84156486
70EPHB10.77791552
71PRKCG0.76778194
72YES10.76680998
73CSNK1G20.74394334
74CAMK2A0.73671605
75FES0.73546972
76PDGFRB0.72604943
77MARK20.71825533
78DYRK1B0.70936809
79TTN0.70854547
80NEK90.70390365
81PDPK10.69978897
82ERBB30.69483742
83CDC42BPA0.66211375
84LATS20.63842189
85MAP3K70.63797357
86CDK150.63738015
87ALK0.63412076
88PTK2B0.62774758
89PDK10.62773917
90CDK140.62648216
91GRK50.62470519
92CDK180.62021374
93ROCK20.61638837
94FYN0.61533802
95ROCK10.60777606
96ICK0.60197779
97NEK60.60191937
98FER0.59722937
99EEF2K0.58428459
100FGR0.57092102
101* RPS6KA30.56789470
102BMX0.56520567
103CAMK2B0.56253540
104CAMK10.56213682
105TAOK10.55960822
106PINK10.55695655
107PRKD10.55379683
108PRKCE0.55236605
109IRAK10.55054185
110BMPR20.53027826
111PRKCZ0.52955794
112MTOR0.51856190
113ERBB20.51511613
114MAPK100.51468551
115DYRK1A0.50294265
116FGFR10.49693701
117CDK11A0.49684271
118WNK40.49299489
119CSNK1A1L0.49028207
120MAPK120.48683788
121PTK20.48507364
122MAP3K120.47313415
123CAMK40.47226656
124RPS6KB10.46928098
125DYRK30.46373322
126MKNK20.46372790
127IRAK20.45505845
128CAMK2G0.41710316
129CDK30.41011902
130PRKAA10.40563367

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.43962303
2Nicotine addiction_Homo sapiens_hsa050332.35980409
3GABAergic synapse_Homo sapiens_hsa047272.11286556
4Circadian entrainment_Homo sapiens_hsa047132.07236791
5Glutamatergic synapse_Homo sapiens_hsa047242.05666131
6Synaptic vesicle cycle_Homo sapiens_hsa047212.02906202
7Olfactory transduction_Homo sapiens_hsa047401.90416321
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90320122
9Morphine addiction_Homo sapiens_hsa050321.86036424
10Long-term potentiation_Homo sapiens_hsa047201.85751216
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74238742
12Salivary secretion_Homo sapiens_hsa049701.69473681
13Gastric acid secretion_Homo sapiens_hsa049711.65053291
14Dopaminergic synapse_Homo sapiens_hsa047281.57789080
15Cholinergic synapse_Homo sapiens_hsa047251.55372264
16Amphetamine addiction_Homo sapiens_hsa050311.53159738
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53151255
18Insulin secretion_Homo sapiens_hsa049111.49509971
19Renin secretion_Homo sapiens_hsa049241.48239158
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47460613
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45157311
22Oxytocin signaling pathway_Homo sapiens_hsa049211.41151619
23Long-term depression_Homo sapiens_hsa047301.40571115
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39555713
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39297286
26Type II diabetes mellitus_Homo sapiens_hsa049301.35632549
27Adherens junction_Homo sapiens_hsa045201.32623726
28Axon guidance_Homo sapiens_hsa043601.32179733
29Dorso-ventral axis formation_Homo sapiens_hsa043201.31108415
30Cocaine addiction_Homo sapiens_hsa050301.24803449
31GnRH signaling pathway_Homo sapiens_hsa049121.24424083
32Glioma_Homo sapiens_hsa052141.22919812
33Gap junction_Homo sapiens_hsa045401.22030891
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21832793
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19052026
36Prolactin signaling pathway_Homo sapiens_hsa049171.18275903
37Dilated cardiomyopathy_Homo sapiens_hsa054141.17561326
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17271456
39Prion diseases_Homo sapiens_hsa050201.15840303
40Calcium signaling pathway_Homo sapiens_hsa040201.15676546
41cAMP signaling pathway_Homo sapiens_hsa040241.13121764
42Serotonergic synapse_Homo sapiens_hsa047261.11330248
43Estrogen signaling pathway_Homo sapiens_hsa049151.10162604
44Taste transduction_Homo sapiens_hsa047421.09620689
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09497785
46Notch signaling pathway_Homo sapiens_hsa043301.06026618
47ErbB signaling pathway_Homo sapiens_hsa040121.04027375
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02815532
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.02313494
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00624975
51Chronic myeloid leukemia_Homo sapiens_hsa052200.99368047
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97786473
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96466832
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94298566
55MicroRNAs in cancer_Homo sapiens_hsa052060.92574981
56Colorectal cancer_Homo sapiens_hsa052100.90574237
57Salmonella infection_Homo sapiens_hsa051320.87834141
58Melanogenesis_Homo sapiens_hsa049160.87202318
59FoxO signaling pathway_Homo sapiens_hsa040680.86426705
60Renal cell carcinoma_Homo sapiens_hsa052110.85874183
61Hippo signaling pathway_Homo sapiens_hsa043900.85696308
62Fatty acid biosynthesis_Homo sapiens_hsa000610.83497307
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.83010909
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82580634
65Choline metabolism in cancer_Homo sapiens_hsa052310.82418718
66TNF signaling pathway_Homo sapiens_hsa046680.81523206
67Pancreatic cancer_Homo sapiens_hsa052120.81313617
68Bile secretion_Homo sapiens_hsa049760.77822120
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76878662
70mTOR signaling pathway_Homo sapiens_hsa041500.76474178
71MAPK signaling pathway_Homo sapiens_hsa040100.75297577
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74350877
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.73783112
74Pancreatic secretion_Homo sapiens_hsa049720.71185188
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71162201
76ECM-receptor interaction_Homo sapiens_hsa045120.69933959
77Rap1 signaling pathway_Homo sapiens_hsa040150.69849831
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68772263
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68264936
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66783112
81Endometrial cancer_Homo sapiens_hsa052130.66756413
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.65983220
83Thyroid hormone synthesis_Homo sapiens_hsa049180.65484204
84Focal adhesion_Homo sapiens_hsa045100.64863601
85VEGF signaling pathway_Homo sapiens_hsa043700.64511133
86Ras signaling pathway_Homo sapiens_hsa040140.64380845
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64092910
88Hedgehog signaling pathway_Homo sapiens_hsa043400.63684110
89Prostate cancer_Homo sapiens_hsa052150.62926811
90Wnt signaling pathway_Homo sapiens_hsa043100.61703942
91Endocytosis_Homo sapiens_hsa041440.61359525
92Insulin signaling pathway_Homo sapiens_hsa049100.60784641
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59807537
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59338659
95Bladder cancer_Homo sapiens_hsa052190.58495127
96Basal cell carcinoma_Homo sapiens_hsa052170.57245647
97HIF-1 signaling pathway_Homo sapiens_hsa040660.57027567
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56303677
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56243883
100Proteoglycans in cancer_Homo sapiens_hsa052050.55450371
101Circadian rhythm_Homo sapiens_hsa047100.55381639
102Glucagon signaling pathway_Homo sapiens_hsa049220.55241765
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.54811664
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.53047523
105Inositol phosphate metabolism_Homo sapiens_hsa005620.52896986
106Non-small cell lung cancer_Homo sapiens_hsa052230.51870924
107Cardiac muscle contraction_Homo sapiens_hsa042600.51638478
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51397696
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50836489
110Insulin resistance_Homo sapiens_hsa049310.49560876
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49510350
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49112829
113Butanoate metabolism_Homo sapiens_hsa006500.48193280
114Collecting duct acid secretion_Homo sapiens_hsa049660.48174400
115Chemokine signaling pathway_Homo sapiens_hsa040620.47808598
116Amoebiasis_Homo sapiens_hsa051460.47073376
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47009672
118Ovarian steroidogenesis_Homo sapiens_hsa049130.46868209
119Tight junction_Homo sapiens_hsa045300.45885814
120Arginine biosynthesis_Homo sapiens_hsa002200.45725349
121Platelet activation_Homo sapiens_hsa046110.45695656
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45556840
123AMPK signaling pathway_Homo sapiens_hsa041520.44636418
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44597889
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42369057
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41653622

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