ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* cell-cell recognition (GO:0009988)	9.82856305
2	epithelial cilium movement (GO:0003351)	9.73116112
3	* plasma membrane fusion (GO:0045026)	9.71202575
4	axonemal dynein complex assembly (GO:0070286)	9.65937650
5	* reproduction (GO:0000003)	9.62013176
6	* binding of sperm to zona pellucida (GO:0007339)	9.59645881
7	motile cilium assembly (GO:0044458)	8.97620649
8	spermatid development (GO:0007286)	8.79307685
9	piRNA metabolic process (GO:0034587)	8.54093911
10	male meiosis (GO:0007140)	8.15411414
11	cilium movement (GO:0003341)	8.04493314
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.67862735
13	* single fertilization (GO:0007338)	7.54052483
14	regulation of cilium movement (GO:0003352)	7.41227338
15	synaptonemal complex assembly (GO:0007130)	7.17808870
16	synaptonemal complex organization (GO:0070193)	7.17643621
17	sperm capacitation (GO:0048240)	6.77073967
18	* fertilization (GO:0009566)	6.44467437
19	microtubule depolymerization (GO:0007019)	6.44137856
20	spermatogenesis (GO:0007283)	6.16872300
21	male gamete generation (GO:0048232)	6.14808766
22	gamete generation (GO:0007276)	5.79852458
23	DNA methylation involved in gamete generation (GO:0043046)	5.57264364
24	negative regulation of inclusion body assembly (GO:0090084)	5.39399913
25	* cellular process involved in reproduction in multicellular organism (GO:0022412)	5.14816156
26	organic cation transport (GO:0015695)	5.11374361
27	germ cell development (GO:0007281)	5.11046406
28	male meiosis I (GO:0007141)	5.05952094
29	microtubule severing (GO:0051013)	5.04086257
30	chromosome organization involved in meiosis (GO:0070192)	5.03088212
31	calcium ion-dependent exocytosis (GO:0017156)	4.90832346
32	spermatid nucleus differentiation (GO:0007289)	4.89229662
33	monoubiquitinated protein deubiquitination (GO:0035520)	4.86709843
34	ventricular system development (GO:0021591)	4.80949375
35	meiotic nuclear division (GO:0007126)	4.75556978
36	* cell recognition (GO:0008037)	4.66928973
37	regulation of inclusion body assembly (GO:0090083)	4.57731583
38	multicellular organismal reproductive process (GO:0048609)	4.56296439
39	glycerol ether metabolic process (GO:0006662)	4.33173994
40	meiotic cell cycle (GO:0051321)	4.29670991
41	regulation of microtubule-based movement (GO:0060632)	4.24949038
42	meiosis I (GO:0007127)	4.13958557
43	seminiferous tubule development (GO:0072520)	4.09047260
44	ether metabolic process (GO:0018904)	3.99717222
45	chromosome condensation (GO:0030261)	3.92721337
46	centriole assembly (GO:0098534)	3.66606500
47	protein K11-linked deubiquitination (GO:0035871)	3.66202789
48	microtubule polymerization or depolymerization (GO:0031109)	3.66085274
49	DNA packaging (GO:0006323)	3.61967352
50	centriole replication (GO:0007099)	3.60288429
51	single strand break repair (GO:0000012)	3.60135317
52	protein polyglutamylation (GO:0018095)	3.56553055
53	multicellular organismal development (GO:0007275)	3.54729920
54	genitalia morphogenesis (GO:0035112)	3.53330472
55	chaperone-mediated protein complex assembly (GO:0051131)	3.39069180
56	left/right pattern formation (GO:0060972)	3.38330397
57	regulation of spindle checkpoint (GO:0090231)	3.29083708
58	meiotic cell cycle process (GO:1903046)	3.27449749
59	gene silencing by RNA (GO:0031047)	3.26007032
60	protein localization to cilium (GO:0061512)	3.20741056
61	sequestering of actin monomers (GO:0042989)	3.15150356
62	regulation of centriole replication (GO:0046599)	3.14764645
63	mitotic sister chromatid cohesion (GO:0007064)	3.09938728
64	polyol catabolic process (GO:0046174)	3.05420359
65	regulation of meiosis I (GO:0060631)	3.03682451
66	cilium organization (GO:0044782)	3.02476895
67	alditol metabolic process (GO:0019400)	3.01858744
68	lactate metabolic process (GO:0006089)	2.98657105
69	synapsis (GO:0007129)	2.97306500
70	cilium morphogenesis (GO:0060271)	2.95219683
71	cilium assembly (GO:0042384)	2.93197489
72	intraciliary transport (GO:0042073)	2.91433265
73	microtubule-based movement (GO:0007018)	2.91082294
74	cellular component assembly involved in morphogenesis (GO:0010927)	2.88248429
75	sexual reproduction (GO:0019953)	2.85619882
76	histone exchange (GO:0043486)	2.81840479
77	amino-acid betaine transport (GO:0015838)	2.79827348
78	carnitine transport (GO:0015879)	2.79827348
79	nucleoside diphosphate phosphorylation (GO:0006165)	2.79102739
80	negative regulation of organelle assembly (GO:1902116)	2.78702590
81	nucleus organization (GO:0006997)	2.77743797
82	sister chromatid cohesion (GO:0007062)	2.76326859
83	glycerol metabolic process (GO:0006071)	2.73240538
84	GTP biosynthetic process (GO:0006183)	2.70178334
85	protein localization to chromosome, centromeric region (GO:0071459)	2.69615979
86	glycolytic process (GO:0006096)	2.66912052
87	carnitine transmembrane transport (GO:1902603)	2.64608559
88	axoneme assembly (GO:0035082)	2.63538995
89	nuclear pore complex assembly (GO:0051292)	2.59597773
90	regulation of acrosome reaction (GO:0060046)	2.51865137
91	regulation of cilium assembly (GO:1902017)	2.51544930
92	cell wall macromolecule metabolic process (GO:0044036)	13.9706048
93	cell wall macromolecule catabolic process (GO:0016998)	13.9706048
94	* fusion of sperm to egg plasma membrane (GO:0007342)	13.1229794
95	acrosome assembly (GO:0001675)	12.0937067
96	sperm motility (GO:0030317)	12.0432553
97	* multicellular organism reproduction (GO:0032504)	11.6493116
98	* sperm-egg recognition (GO:0035036)	11.0368152
99	cilium or flagellum-dependent cell motility (GO:0001539)	10.7000732
100	acrosome reaction (GO:0007340)	10.1776056

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	9.13001371
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.82999403
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.51719777
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.42804262
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.81851904
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.81691474
7	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.54071575
8	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.49712645
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.45277431
10	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.41540727
11	KAP1_22055183_ChIP-Seq_ESCs_Mouse	2.37455444
12	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	2.08448927
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.03844663
14	VDR_22108803_ChIP-Seq_LS180_Human	1.98286056
15	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.96600635
16	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.96455292
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.95940708
18	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.93003619
19	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.91034189
20	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.90242557
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.88217906
22	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.86635781
23	STAT1_17558387_ChIP-Seq_HELA_Human	1.82171446
24	KDM2B_26808549_Chip-Seq_REH_Human	1.72360970
25	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.69651487
26	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.69629206
27	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.68185524
28	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.68074143
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.65057660
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.65037983
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.63154969
32	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.61998517
33	* TAL1_26923725_Chip-Seq_HPCs_Mouse	1.61855002
34	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.60915792
35	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.48219966
36	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.45207796
37	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.43967726
38	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43846457
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41704598
40	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41036729
41	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.39934077
42	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.39548139
43	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.38787817
44	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.37607309
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.37010844
46	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.34648224
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32587534
48	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.32545827
49	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.31817396
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30700361
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.30700361
52	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.30171236
53	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.30136863
54	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.28688996
55	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.26003880
56	P53_22387025_ChIP-Seq_ESCs_Mouse	1.25884860
57	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.23959805
58	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.23580398
59	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.23492128
60	P300_18555785_Chip-Seq_ESCs_Mouse	1.21555909
61	TAF15_26573619_Chip-Seq_HEK293_Human	1.21522701
62	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.20240068
63	GF1_26923725_Chip-Seq_HPCs_Mouse	1.19943200
64	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.18604459
65	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17093530
66	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.16755810
67	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.15546877
68	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.15377298
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.15232582
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15232582
71	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.14604058
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14218336
73	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.11234059
74	P53_21459846_ChIP-Seq_SAOS-2_Human	1.09076165
75	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.07849679
76	GF1B_26923725_Chip-Seq_HPCs_Mouse	1.06915615
77	FUS_26573619_Chip-Seq_HEK293_Human	1.06212064
78	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.04974178
79	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.03396949
80	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01660057
81	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.01158366
82	ERG_20517297_ChIP-Seq_VCAP_Human	1.01017210
83	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00545412
84	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.00510017
85	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.99149230
86	PU1_27457419_Chip-Seq_LIVER_Mouse	0.98367130
87	SOX9_26525672_Chip-Seq_HEART_Mouse	0.97989310
88	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97625492
89	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.97363814
90	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.96624828
91	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.96153447
92	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.96146500
93	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.96076375
94	SPI1_26923725_Chip-Seq_HPCs_Mouse	0.95754862
95	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.94667061
96	STAT3_18555785_ChIP-Seq_MESCs_Mouse	0.91814351
97	NFYB_21822215_ChIP-Seq_K562_Human	0.91046730
98	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89656156
99	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.89633357
100	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.87414457

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	* MP0003698_abnormal_male_reproductive	5.90603098
2	MP0001929_abnormal_gametogenesis	5.87387826
3	MP0008877_abnormal_DNA_methylation	5.35771812
4	MP0002210_abnormal_sex_determination	3.88650674
5	MP0002653_abnormal_ependyma_morphology	3.50330089
6	MP0002161_abnormal_fertility/fecundity	3.49876048
7	MP0001145_abnormal_male_reproductive	3.22897895
8	MP0000653_abnormal_sex_gland	3.08619482
9	MP0003646_muscle_fatigue	2.25970856
10	MP0005670_abnormal_white_adipose	2.19548904
11	* MP0005410_abnormal_fertilization	14.4784032
12	MP0002102_abnormal_ear_morphology	1.93646251
13	MP0004233_abnormal_muscle_weight	1.65848829
14	MP0002160_abnormal_reproductive_system	1.61860285
15	MP0010094_abnormal_chromosome_stability	1.56284642
16	MP0005623_abnormal_meninges_morphology	1.45931433
17	MP0008058_abnormal_DNA_repair	1.37677343
18	MP0002282_abnormal_trachea_morphology	1.35631087
19	MP0005451_abnormal_body_composition	1.32858510
20	MP0005647_abnormal_sex_gland	1.27696643
21	MP0003718_maternal_effect	1.21596262
22	MP0003699_abnormal_female_reproductive	1.18771067
23	MP0008057_abnormal_DNA_replication	1.14764492
24	MP0001765_abnormal_ion_homeostasis	1.11948040
25	MP0001119_abnormal_female_reproductive	1.11483864
26	MP0005389_reproductive_system_phenotype	1.02256735
27	MP0003111_abnormal_nucleus_morphology	0.97816777
28	MP0001984_abnormal_olfaction	0.90418223
29	MP0008995_early_reproductive_senescence	0.90380726
30	MP0009046_muscle_twitch	0.90361329
31	MP0003950_abnormal_plasma_membrane	0.85981049
32	MP0003077_abnormal_cell_cycle	0.82277892
33	MP0003011_delayed_dark_adaptation	0.69370782
34	MP0008007_abnormal_cellular_replicative	0.67478714
35	MP0002234_abnormal_pharynx_morphology	0.62709794
36	MP0003787_abnormal_imprinting	0.60027831
37	MP0003786_premature_aging	0.55935881
38	MP0005636_abnormal_mineral_homeostasis	0.53638851
39	MP0001730_embryonic_growth_arrest	0.52855410
40	MP0005395_other_phenotype	0.52621020
41	MP0003693_abnormal_embryo_hatching	0.51115814
42	MP0002928_abnormal_bile_duct	0.49239304
43	MP0004036_abnormal_muscle_relaxation	0.48491016
44	MP0001529_abnormal_vocalization	0.46045217
45	MP0006072_abnormal_retinal_apoptosis	0.44803795
46	MP0005551_abnormal_eye_electrophysiolog	0.44486007
47	MP0002269_muscular_atrophy	0.43528997
48	MP0010307_abnormal_tumor_latency	0.41899279
49	MP0004957_abnormal_blastocyst_morpholog	0.41771486
50	MP0003115_abnormal_respiratory_system	0.41711814
51	MP0000462_abnormal_digestive_system	0.40208213
52	MP0002084_abnormal_developmental_patter	0.38502515
53	MP0005253_abnormal_eye_physiology	0.38359183
54	MP0008932_abnormal_embryonic_tissue	0.37075710
55	MP0004145_abnormal_muscle_electrophysio	0.37050351
56	MP0002085_abnormal_embryonic_tissue	0.36995588
57	MP0002139_abnormal_hepatobiliary_system	0.36782555
58	MP0003861_abnormal_nervous_system	0.36603754
59	MP0001697_abnormal_embryo_size	0.35691069
60	MP0000358_abnormal_cell_content/	0.35597738
61	MP0005666_abnormal_adipose_tissue	0.35262680
62	MP0001324_abnormal_eye_pigmentation	0.34939957
63	MP0000579_abnormal_nail_morphology	0.33941234
64	MP0005646_abnormal_pituitary_gland	0.33323376
65	MP0005397_hematopoietic_system_phenotyp	0.31881263
66	MP0001545_abnormal_hematopoietic_system	0.31881263
67	MP0003329_amyloid_beta_deposits	0.31860290
68	MP0003937_abnormal_limbs/digits/tail_de	0.31233888
69	MP0001919_abnormal_reproductive_system	0.30837805
70	MP0002971_abnormal_brown_adipose	0.30427061
71	MP0002736_abnormal_nociception_after	0.30033430
72	MP0001672_abnormal_embryogenesis/_devel	0.28385164
73	MP0005380_embryogenesis_phenotype	0.28385164
74	MP0000427_abnormal_hair_cycle	0.28260259
75	MP0000313_abnormal_cell_death	0.28112771
76	MP0000432_abnormal_head_morphology	0.27781725
77	MP0000569_abnormal_digit_pigmentation	0.26732049
78	MP0005408_hypopigmentation	0.26630276
79	MP0005391_vision/eye_phenotype	0.26598611
80	MP0009115_abnormal_fat_cell	0.25687615
81	MP0001293_anophthalmia	0.25387709
82	MP0004270_analgesia	0.24261103
83	MP0000639_abnormal_adrenal_gland	0.23943998
84	MP0002152_abnormal_brain_morphology	0.23716738
85	MP0006036_abnormal_mitochondrial_physio	0.23605928
86	MP0009697_abnormal_copulation	0.22658340
87	MP0005377_hearing/vestibular/ear_phenot	0.21730050
88	MP0003878_abnormal_ear_physiology	0.21730050
89	MP0002295_abnormal_pulmonary_circulatio	0.21464350
90	MP0000534_abnormal_ureter_morphology	0.20439510
91	MP0005195_abnormal_posterior_eye	0.20344464
92	MP0004133_heterotaxia	0.20150132
93	MP0002169_no_abnormal_phenotype	0.19992833
94	MP0002873_normal_phenotype	0.19803455
95	MP0009250_abnormal_appendicular_skeleto	0.19581144
96	MP0001851_eye_inflammation	0.19498461
97	MP0004019_abnormal_vitamin_homeostasis	0.19464500
98	MP0002109_abnormal_limb_morphology	0.18516412
99	MP0005187_abnormal_penis_morphology	0.18350104
100	MP0003315_abnormal_perineum_morphology	0.18314907

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	9.47980165
2	Abnormal respiratory motile cilium morphology (HP:0005938)	8.78753119
3	Abnormal respiratory epithelium morphology (HP:0012253)	8.78753119
4	Abnormal ciliary motility (HP:0012262)	7.75223109
5	Rhinitis (HP:0012384)	7.59957723
6	Chronic bronchitis (HP:0004469)	7.59704081
7	Infertility (HP:0000789)	6.52520121
8	Nasal polyposis (HP:0100582)	5.86888828
9	Male infertility (HP:0003251)	5.21393291
10	Abnormality of the nasal mucosa (HP:0000433)	4.77765894
11	Bronchiectasis (HP:0002110)	4.43478915
12	Bronchitis (HP:0012387)	4.37109228
13	Nephronophthisis (HP:0000090)	4.34771014
14	Recurrent sinusitis (HP:0011108)	3.54888655
15	Abnormal spermatogenesis (HP:0008669)	3.44945018
16	Abnormality of the renal medulla (HP:0100957)	3.32481356
17	Medial flaring of the eyebrow (HP:0010747)	3.15052836
18	Recurrent otitis media (HP:0000403)	3.13699964
19	Molar tooth sign on MRI (HP:0002419)	2.92557749
20	Abnormality of midbrain morphology (HP:0002418)	2.92557749
21	Tubulointerstitial nephritis (HP:0001970)	2.60690485
22	Azoospermia (HP:0000027)	2.54655101
23	Gait imbalance (HP:0002141)	2.27974904
24	Tubular atrophy (HP:0000092)	2.27493899
25	Congenital primary aphakia (HP:0007707)	2.26770939
26	Impulsivity (HP:0100710)	2.23163355
27	Recurrent bronchitis (HP:0002837)	2.22045992
28	Tubulointerstitial abnormality (HP:0001969)	2.18140313
29	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	13.5493861
30	Dynein arm defect of respiratory motile cilia (HP:0012255)	12.8537054
31	Absent/shortened dynein arms (HP:0200106)	12.8537054
32	Nephrogenic diabetes insipidus (HP:0009806)	1.95512822
33	Pancreatic fibrosis (HP:0100732)	1.94149538
34	Gonadotropin excess (HP:0000837)	1.91645739
35	Postaxial foot polydactyly (HP:0001830)	1.89369733
36	Genital tract atresia (HP:0001827)	1.85762589
37	Vaginal atresia (HP:0000148)	1.83265764
38	Abnormal gallbladder physiology (HP:0012438)	1.82873296
39	Cholecystitis (HP:0001082)	1.82873296
40	Stage 5 chronic kidney disease (HP:0003774)	1.82459175
41	Poor coordination (HP:0002370)	1.80830364
42	Supernumerary spleens (HP:0009799)	1.73833272
43	Microglossia (HP:0000171)	1.73789167
44	Aplasia/Hypoplasia of the lens (HP:0008063)	1.71649905
45	Congenital hepatic fibrosis (HP:0002612)	1.71230867
46	Papillary thyroid carcinoma (HP:0002895)	1.70157572
47	Tubulointerstitial fibrosis (HP:0005576)	1.70129728
48	Postaxial hand polydactyly (HP:0001162)	1.66687838
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.65857264
50	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.62427649
51	Abnormality of the renal cortex (HP:0011035)	1.61183827
52	Abnormality of permanent molar morphology (HP:0011071)	1.60949032
53	Abnormality of the dental root (HP:0006486)	1.60949032
54	Taurodontia (HP:0000679)	1.60949032
55	Cystic liver disease (HP:0006706)	1.60456612
56	Heterotopia (HP:0002282)	1.59117234
57	Abnormal biliary tract physiology (HP:0012439)	1.58630815
58	Bile duct proliferation (HP:0001408)	1.58630815
59	Tongue fasciculations (HP:0001308)	1.52604248
60	True hermaphroditism (HP:0010459)	1.50959207
61	Abnormality of molar morphology (HP:0011070)	1.48842871
62	Abnormality of molar (HP:0011077)	1.48842871
63	Oculomotor apraxia (HP:0000657)	1.48044355
64	Short ribs (HP:0000773)	1.47563874
65	Abnormality of the dental pulp (HP:0006479)	1.46636273
66	Abnormal drinking behavior (HP:0030082)	1.44998810
67	Polydipsia (HP:0001959)	1.44998810
68	Chronic sinusitis (HP:0011109)	1.44111031
69	Renal dysplasia (HP:0000110)	1.43853735
70	Fibular hypoplasia (HP:0003038)	1.43130729
71	Abnormality of renal excretion (HP:0011036)	1.43084472
72	Decreased central vision (HP:0007663)	1.42959340
73	Spastic tetraparesis (HP:0001285)	1.42834441
74	Pancreatic cysts (HP:0001737)	1.42194261
75	Dyschromatopsia (HP:0007641)	1.41207034
76	Muscle fibrillation (HP:0010546)	1.38066759
77	Abnormality of dentin (HP:0010299)	1.33661530
78	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.33012436
79	Abnormality of the lower motor neuron (HP:0002366)	1.32788177
80	Facial cleft (HP:0002006)	1.32624712
81	Asymmetric septal hypertrophy (HP:0001670)	1.30467556
82	Absent frontal sinuses (HP:0002688)	1.29648062
83	Chronic hepatic failure (HP:0100626)	1.26979084
84	Absent epiphyses (HP:0010577)	1.25376859
85	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.25376859
86	Sloping forehead (HP:0000340)	1.24453961
87	Bundle branch block (HP:0011710)	1.23276924
88	Median cleft lip (HP:0000161)	1.21025719
89	Amyotrophic lateral sclerosis (HP:0007354)	1.20593292
90	Abnormality of the neuromuscular junction (HP:0003398)	1.19633592
91	Fatigable weakness (HP:0003473)	1.19633592
92	Nephroblastoma (Wilms tumor) (HP:0002667)	1.19533858
93	Abnormality of saccadic eye movements (HP:0000570)	1.18752027
94	Easy fatigability (HP:0003388)	1.18406257
95	Cerebellar dysplasia (HP:0007033)	1.14474436
96	Type 2 muscle fiber atrophy (HP:0003554)	1.13398688
97	Occipital encephalocele (HP:0002085)	1.13206909
98	Breast carcinoma (HP:0003002)	1.11641189
99	Broad foot (HP:0001769)	1.11479594
100	Optic nerve hypoplasia (HP:0000609)	1.10292285

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK3	8.78425922
2	PDK4	8.78425922
3	PDK2	5.64863872
4	TESK1	4.04199914
5	PRKD3	3.97669287
6	ICK	2.69839355
7	PTK2B	1.96841462
8	STK39	1.94490533
9	WNK4	1.79765845
10	NEK2	1.78205695
11	PLK4	1.77310720
12	PNCK	1.56620947
13	TTK	1.53881922
14	STK38	1.51404610
15	STK38L	1.36167010
16	LATS1	1.29574645
17	MUSK	1.15981924
18	STK3	1.15047770
19	CHEK2	1.06318122
20	MAP3K6	1.03406477
21	TYRO3	1.01298672
22	PDK1	0.99520600
23	EEF2K	0.95473398
24	CDC7	0.92472374
25	BRAF	0.82327083
26	DYRK1B	0.77989448
27	LATS2	0.75945722
28	ERBB4	0.74293756
29	DYRK3	0.69651296
30	LMTK2	0.69589077
31	MOS	0.65773370
32	TAOK3	0.61829345
33	TESK2	0.61260770
34	CCNB1	0.59709517
35	PLK1	0.57365474
36	CHEK1	0.55950947
37	WNK1	0.53380844
38	STK10	0.52733399
39	IRAK1	0.52396888
40	CDK12	0.52002071
41	BMPR2	0.51763287
42	WEE1	0.50064026
43	PDPK1	0.44483371
44	ATM	0.43478417
45	PASK	0.42687316
46	MAP2K7	0.42346937
47	MAP3K4	0.41092797
48	MAPKAPK5	0.40189923
49	BRSK2	0.39531311
50	TAOK1	0.38361277
51	MAP2K6	0.38286996
52	PINK1	0.37703806
53	PAK1	0.37196170
54	MAPK15	0.36225365
55	PAK6	0.35792260
56	PRKAA1	0.34860647
57	ATR	0.33684892
58	DYRK2	0.33566004
59	KSR2	0.33059060
60	MELK	0.30913263
61	MARK2	0.30548636
62	NTRK2	0.30246381
63	MAP3K9	0.24847036
64	MAPKAPK3	0.21824966
65	CAMK1G	0.20201511
66	CDK15	0.18813178
67	NEK6	0.18810466
68	AURKA	0.18488595
69	CDK9	0.17625966
70	PKN1	0.16380345
71	CSNK1D	0.16096665
72	BRSK1	0.15892962
73	CDK18	0.15608078
74	AURKB	0.14346537
75	MAP3K5	0.14143942
76	MTOR	0.13872000
77	CDK3	0.13818798
78	CDK11A	0.13159811
79	PRKG2	0.13052458
80	CDK1	0.12230173
81	CAMK2A	0.12159337
82	PAK2	0.11834953
83	MAP3K8	0.10853569
84	PRKG1	0.10055552
85	CDK2	0.09241786
86	CDK14	0.07770655
87	BUB1	0.07463884
88	RPS6KB1	0.06396528
89	IRAK2	0.06341449
90	PRKCG	0.06215181
91	RIPK4	0.06211781
92	GSK3B	0.05658656
93	PRKCQ	0.04238676
94	CDK4	0.04158140
95	PRKAA2	0.02789228
96	CSNK2A1	0.02618661
97	BMPR1B	0.02437849
98	MAPK13	0.01491064
99	STK11	-0.0069373
100	RAF1	-0.0034062

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	5.34590978
2	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	4.01740248
3	Basal transcription factors_Homo sapiens_hsa03022	3.72146683
4	Pyruvate metabolism_Homo sapiens_hsa00620	3.71570127
5	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.37414780
6	Propanoate metabolism_Homo sapiens_hsa00640	3.08170592
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.04943569
8	Linoleic acid metabolism_Homo sapiens_hsa00591	3.00519360
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.69796718
10	Oocyte meiosis_Homo sapiens_hsa04114	2.54951049
11	Glucagon signaling pathway_Homo sapiens_hsa04922	2.52785844
12	Pentose phosphate pathway_Homo sapiens_hsa00030	2.27698920
13	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.94416544
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.87330447
15	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.81327220
16	Glycerolipid metabolism_Homo sapiens_hsa00561	1.80291224
17	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.80276777
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.74129848
19	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.60725664
20	PPAR signaling pathway_Homo sapiens_hsa03320	1.59377687
21	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.57536418
22	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.50790777
23	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.50037291
24	Cell cycle_Homo sapiens_hsa04110	1.47631257
25	RNA transport_Homo sapiens_hsa03013	1.44528233
26	mRNA surveillance pathway_Homo sapiens_hsa03015	1.30032496
27	Purine metabolism_Homo sapiens_hsa00230	1.22682443
28	Amphetamine addiction_Homo sapiens_hsa05031	1.21365507
29	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.19458718
30	Huntingtons disease_Homo sapiens_hsa05016	1.17544973
31	RNA degradation_Homo sapiens_hsa03018	1.16643404
32	Mineral absorption_Homo sapiens_hsa04978	1.16152863
33	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.13460466
34	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.10863465
35	Carbon metabolism_Homo sapiens_hsa01200	1.08775853
36	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.07592016
37	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.97945698
38	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.91648563
39	Renin secretion_Homo sapiens_hsa04924	0.90397522
40	Cardiac muscle contraction_Homo sapiens_hsa04260	0.89473574
41	Homologous recombination_Homo sapiens_hsa03440	0.84706484
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83565629
43	Glutathione metabolism_Homo sapiens_hsa00480	0.82727167
44	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.81556462
45	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.78928162
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76717702
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75483850
48	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.71384919
49	Fatty acid metabolism_Homo sapiens_hsa01212	0.69031099
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68899169
51	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.68113221
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67442219
53	Fatty acid degradation_Homo sapiens_hsa00071	0.65926649
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65484236
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.65092696
56	Estrogen signaling pathway_Homo sapiens_hsa04915	0.64907095
57	Renin-angiotensin system_Homo sapiens_hsa04614	0.58121761
58	Long-term potentiation_Homo sapiens_hsa04720	0.56301281
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55622316
60	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.55598145
61	VEGF signaling pathway_Homo sapiens_hsa04370	0.55056629
62	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.54823674
63	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.53794456
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.53371274
65	Antigen processing and presentation_Homo sapiens_hsa04612	0.52729521
66	Insulin secretion_Homo sapiens_hsa04911	0.50155867
67	Calcium signaling pathway_Homo sapiens_hsa04020	0.42927359
68	p53 signaling pathway_Homo sapiens_hsa04115	0.42917162
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.42852293
70	Bile secretion_Homo sapiens_hsa04976	0.41991504
71	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.40183955
72	AMPK signaling pathway_Homo sapiens_hsa04152	0.35765491
73	* Metabolic pathways_Homo sapiens_hsa01100	0.34530502
74	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.34513258
75	cAMP signaling pathway_Homo sapiens_hsa04024	0.34212214
76	Circadian rhythm_Homo sapiens_hsa04710	0.31870592
77	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31852500
78	Non-homologous end-joining_Homo sapiens_hsa03450	0.30474945
79	Endocytosis_Homo sapiens_hsa04144	0.30381608
80	Protein digestion and absorption_Homo sapiens_hsa04974	0.30016491
81	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.29453127
82	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.27439752
83	Taste transduction_Homo sapiens_hsa04742	0.27421102
84	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.25758784
85	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.25326061
86	Pancreatic secretion_Homo sapiens_hsa04972	0.24708023
87	Wnt signaling pathway_Homo sapiens_hsa04310	0.24062716
88	ABC transporters_Homo sapiens_hsa02010	0.23942627
89	Base excision repair_Homo sapiens_hsa03410	0.23919478
90	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.21705367
91	DNA replication_Homo sapiens_hsa03030	0.17162494
92	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.17036092
93	Salivary secretion_Homo sapiens_hsa04970	0.16964480
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.16319997
95	Viral carcinogenesis_Homo sapiens_hsa05203	0.15693245
96	Retinol metabolism_Homo sapiens_hsa00830	0.14470264
97	Nucleotide excision repair_Homo sapiens_hsa03420	0.13968786
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.12987994
99	Gastric acid secretion_Homo sapiens_hsa04971	0.11882913
100	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.09332017

SPAM1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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