SPANXD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.97217875
2response to pheromone (GO:0019236)8.65250455
3gonadal mesoderm development (GO:0007506)8.65176962
4chromosome condensation (GO:0030261)8.62012298
5plasma membrane fusion (GO:0045026)8.41012752
6DNA packaging (GO:0006323)8.13933174
7sperm capacitation (GO:0048240)7.68798867
8rRNA methylation (GO:0031167)7.01234677
9microtubule depolymerization (GO:0007019)7.01154275
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.92408055
11sperm-egg recognition (GO:0035036)6.92091385
12spermatid development (GO:0007286)6.89192169
13spermatid nucleus differentiation (GO:0007289)6.87781096
14single strand break repair (GO:0000012)6.79102074
15multicellular organism reproduction (GO:0032504)6.54240748
16binding of sperm to zona pellucida (GO:0007339)6.41208893
17rRNA modification (GO:0000154)6.30405385
18reproduction (GO:0000003)6.14410419
19sexual reproduction (GO:0019953)5.89548937
20calcium ion-dependent exocytosis (GO:0017156)5.65487330
21spermatogenesis (GO:0007283)5.56961626
22male gamete generation (GO:0048232)5.54780362
23cell-cell recognition (GO:0009988)5.53842925
24one-carbon compound transport (GO:0019755)5.42646217
25microtubule polymerization or depolymerization (GO:0031109)5.29577634
26gamete generation (GO:0007276)5.08269057
27negative regulation of inclusion body assembly (GO:0090084)5.06659095
28axonemal dynein complex assembly (GO:0070286)4.88864320
29centriole replication (GO:0007099)4.73954349
30phosphatidylethanolamine biosynthetic process (GO:0006646)4.73360820
31protein polyglutamylation (GO:0018095)4.70485197
32regulation of cilium movement (GO:0003352)4.55743996
33single fertilization (GO:0007338)4.49162983
34phosphatidylethanolamine metabolic process (GO:0046337)4.30923005
35centriole assembly (GO:0098534)4.24780390
36cellular ketone body metabolic process (GO:0046950)4.23428434
37glycerol ether metabolic process (GO:0006662)4.16825686
38multicellular organismal reproductive process (GO:0048609)4.03958157
39protein targeting to Golgi (GO:0000042)3.97648946
40positive regulation of Rab GTPase activity (GO:0032851)3.96111795
41regulation of Rab GTPase activity (GO:0032313)3.96111795
42chromatin silencing (GO:0006342)3.88760210
43motile cilium assembly (GO:0044458)3.85506967
44ether metabolic process (GO:0018904)3.84583629
45microtubule severing (GO:0051013)3.82212494
46regulation of centriole replication (GO:0046599)3.76320729
47establishment of protein localization to Golgi (GO:0072600)3.75488448
48germ cell development (GO:0007281)3.74132077
49retrograde transport, vesicle recycling within Golgi (GO:0000301)3.73710936
50ketone body metabolic process (GO:1902224)3.72787890
51cell wall macromolecule catabolic process (GO:0016998)3.67072271
52cellular process involved in reproduction in multicellular organism (GO:0022412)3.65698052
53coenzyme catabolic process (GO:0009109)3.54299375
54regulation of inclusion body assembly (GO:0090083)3.53500506
55cell wall macromolecule metabolic process (GO:0044036)3.51408772
56peptidyl-proline hydroxylation (GO:0019511)3.50647368
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50456987
58cranial nerve morphogenesis (GO:0021602)3.47733022
59nucleus organization (GO:0006997)3.44586367
60regulation of transcription involved in cell fate commitment (GO:0060850)3.43740600
61pattern specification involved in kidney development (GO:0061004)3.43440506
62hepatocyte apoptotic process (GO:0097284)3.42655029
63seminiferous tubule development (GO:0072520)3.42210700
64fertilization (GO:0009566)3.33738347
65receptor recycling (GO:0001881)3.32296486
66neutrophil activation involved in immune response (GO:0002283)3.14804199
67kidney mesenchyme development (GO:0072074)3.11091357
68positive regulation of T cell mediated cytotoxicity (GO:0001916)3.10386780
69positive regulation of endothelial cell differentiation (GO:0045603)3.09054480
70mesenchymal cell differentiation involved in renal system development (GO:2001012)3.08625213
71mesenchymal cell differentiation involved in kidney development (GO:0072161)3.08625213
72innate immune response in mucosa (GO:0002227)3.07873594
73left/right axis specification (GO:0070986)3.07596952
74metanephric mesenchyme development (GO:0072075)3.04744879
75ATP synthesis coupled proton transport (GO:0015986)3.04293783
76energy coupled proton transport, down electrochemical gradient (GO:0015985)3.04293783
77protein localization to Golgi apparatus (GO:0034067)3.03759646
78proteasome assembly (GO:0043248)3.00101709
79negative regulation of gene silencing (GO:0060969)2.95428424
80polyamine biosynthetic process (GO:0006596)2.94756821
81histone mRNA metabolic process (GO:0008334)2.93368359
824-hydroxyproline metabolic process (GO:0019471)2.93015088
83outer ear morphogenesis (GO:0042473)2.90905746
84musculoskeletal movement (GO:0050881)2.90058411
85multicellular organismal movement (GO:0050879)2.90058411
86cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.89668637
87spliceosomal complex assembly (GO:0000245)2.88444147
88regulation of interleukin-13 production (GO:0032656)2.87070878
89histone exchange (GO:0043486)2.86050944
90mitochondrial fission (GO:0000266)2.85132919
91membrane protein intracellular domain proteolysis (GO:0031293)2.81828380
92meiosis I (GO:0007127)2.80199080
93RNA destabilization (GO:0050779)2.79848279
94viral transcription (GO:0019083)2.78777973
95respiratory electron transport chain (GO:0022904)2.76296528
96protein refolding (GO:0042026)2.74894795
97nucleosome disassembly (GO:0006337)2.74605391
98protein-DNA complex disassembly (GO:0032986)2.74605391
99fusion of sperm to egg plasma membrane (GO:0007342)11.0875101
100acrosome reaction (GO:0007340)10.9246139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.27419676
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.84874831
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.61351221
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.91013137
5ELF1_20517297_ChIP-Seq_JURKAT_Human2.74374743
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73245709
7EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.47919217
8RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.33506833
9EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.29862928
10BCL6_27268052_Chip-Seq_Bcells_Human2.26940340
11TDRD3_21172665_ChIP-Seq_MCF-7_Human2.17377812
12CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.09428774
13FUS_26573619_Chip-Seq_HEK293_Human2.06509871
14CTCF_20526341_ChIP-Seq_ESCs_Human2.02979612
15MYC_19829295_ChIP-Seq_ESCs_Human1.99501045
16E2F1_20622854_ChIP-Seq_HELA_Human1.98578147
17ERG_20517297_ChIP-Seq_VCAP_Human1.98206420
18PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.96065798
19VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.95291155
20RAC3_21632823_ChIP-Seq_H3396_Human1.92590045
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91860010
22YY1_22570637_ChIP-Seq_MALME-3M_Human1.89941432
23ERA_21632823_ChIP-Seq_H3396_Human1.86501605
24CBP_20019798_ChIP-Seq_JUKART_Human1.86094408
25IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.86094408
26NANOG_20526341_ChIP-Seq_ESCs_Human1.85918037
27TAF2_19829295_ChIP-Seq_ESCs_Human1.85633626
28BCOR_27268052_Chip-Seq_Bcells_Human1.84891095
29EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.84298810
30P300_27268052_Chip-Seq_Bcells_Human1.80295118
31P68_20966046_ChIP-Seq_HELA_Human1.77553102
32CTCF_27219007_Chip-Seq_Bcells_Human1.77171333
33PHF8_20622854_ChIP-Seq_HELA_Human1.77011576
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73724878
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.64053670
36AUTS2_25519132_ChIP-Seq_293T-REX_Human1.62486184
37CSB_26484114_Chip-Seq_FIBROBLAST_Human1.60239144
38JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59507986
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.56980220
40SA1_27219007_Chip-Seq_Bcells_Human1.55820965
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.55649606
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54352495
43TP63_22573176_ChIP-Seq_HFKS_Human1.51331345
44SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.49345304
45STAT1_20625510_ChIP-Seq_HELA_Human1.48362931
46LXR_22292898_ChIP-Seq_THP-1_Human1.47840386
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47391125
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46989274
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46989274
50RBPJ_21746931_ChIP-Seq_IB4_Human1.39281555
51HNFA_21074721_ChIP-Seq_CACO-2_Human1.36313895
52E2F1_17053090_ChIP-ChIP_MCF-7_Human1.35713368
53JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35258497
54SOX2_22085726_ChIP-Seq_NPCs_Mouse1.32931264
55CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.32477577
56OCT4_20526341_ChIP-Seq_ESCs_Human1.31169967
57P53_21459846_ChIP-Seq_SAOS-2_Human1.29014318
58GATA6_21074721_ChIP-Seq_CACO-2_Human1.28996147
59SALL4_22934838_ChIP-ChIP_CD34+_Human1.27547283
60SPI1_20517297_ChIP-Seq_HL60_Human1.27246807
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.24967432
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24584813
63FOXH1_21741376_ChIP-Seq_EPCs_Human1.24121310
64P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.22444778
65GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.21432364
66TP53_18474530_ChIP-ChIP_U2OS_Human1.20888027
67SMC4_20622854_ChIP-Seq_HELA_Human1.20109192
68ER_23166858_ChIP-Seq_MCF-7_Human1.18432314
69ETV1_20927104_ChIP-Seq_GIST48_Human1.18251326
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.17910974
71CBX2_22325352_ChIP-Seq_293T-Rex_Human1.14930312
72WDR5_24793694_ChIP-Seq_LNCAP_Human1.13396826
73GATA3_21867929_ChIP-Seq_CD8_Mouse1.12995347
74FOXP1_21924763_ChIP-Seq_HESCs_Human1.12346453
75PHF8_20622853_ChIP-Seq_HELA_Human1.11343591
76HOXB7_26014856_ChIP-Seq_BT474_Human1.09777456
77MYC_18555785_ChIP-Seq_MESCs_Mouse1.07093780
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06019098
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04971018
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03202926
81SOX2_21211035_ChIP-Seq_LN229_Human1.02603408
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.02398636
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02398636
84FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02064976
85CEBPB_22108803_ChIP-Seq_LS180_Human1.01678914
86CTCF_21964334_Chip-Seq_Bcells_Human1.01281846
87KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99820789
88* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99722922
89RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99392279
90SA1_27219007_Chip-Seq_ERYTHROID_Human0.98638408
91* CJUN_26792858_Chip-Seq_BT549_Human0.97726916
92PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95271514
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.94117370
94NFYB_21822215_ChIP-Seq_K562_Human0.93216329
95MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92143295
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.91975930
97NFYA_21822215_ChIP-Seq_K562_Human0.91665249
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91418059
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90895680
100JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90629545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.07030385
2MP0000516_abnormal_urinary_system3.76213725
3MP0005367_renal/urinary_system_phenotyp3.76213725
4MP0001348_abnormal_lacrimal_gland3.56489782
5MP0003698_abnormal_male_reproductive3.53374356
6MP0003011_delayed_dark_adaptation3.38288508
7MP0003646_muscle_fatigue3.35244615
8MP0002837_dystrophic_cardiac_calcinosis3.13655748
9MP0001929_abnormal_gametogenesis3.11962911
10MP0003878_abnormal_ear_physiology3.00517322
11MP0005377_hearing/vestibular/ear_phenot3.00517322
12MP0008995_early_reproductive_senescence2.49159420
13MP0009379_abnormal_foot_pigmentation2.14121873
14MP0005379_endocrine/exocrine_gland_phen2.13007643
15MP0002234_abnormal_pharynx_morphology2.11884711
16MP0000534_abnormal_ureter_morphology2.10040394
17MP0005410_abnormal_fertilization11.0038308
18MP0002161_abnormal_fertility/fecundity1.94673526
19MP0009764_decreased_sensitivity_to1.88154454
20MP0003718_maternal_effect1.82683371
21MP0005408_hypopigmentation1.81992944
22MP0003806_abnormal_nucleotide_metabolis1.79806191
23MP0000678_abnormal_parathyroid_gland1.77092742
24MP0008877_abnormal_DNA_methylation1.69462632
25MP0003252_abnormal_bile_duct1.62651954
26MP0008775_abnormal_heart_ventricle1.48267978
27MP0002282_abnormal_trachea_morphology1.47872968
28MP0001853_heart_inflammation1.42290315
29MP0004510_myositis1.39517019
30MP0002210_abnormal_sex_determination1.36762986
31MP0002132_abnormal_respiratory_system1.35283886
32MP0002249_abnormal_larynx_morphology1.33378900
33MP0009053_abnormal_anal_canal1.23665163
34MP0000681_abnormal_thyroid_gland1.22981034
35MP0004084_abnormal_cardiac_muscle1.19205505
36MP0009697_abnormal_copulation1.09868447
37MP0001765_abnormal_ion_homeostasis1.08424120
38MP0001145_abnormal_male_reproductive1.04933340
39MP0005266_abnormal_metabolism1.03100123
40MP0001727_abnormal_embryo_implantation1.01125895
41MP0005423_abnormal_somatic_nervous1.00421062
42MP0001963_abnormal_hearing_physiology1.00029802
43MP0001968_abnormal_touch/_nociception0.99691036
44MP0002928_abnormal_bile_duct0.99064166
45MP0004742_abnormal_vestibular_system0.97472336
46MP0001486_abnormal_startle_reflex0.96059715
47MP0000653_abnormal_sex_gland0.93531108
48MP0003077_abnormal_cell_cycle0.92102499
49MP0005395_other_phenotype0.84355065
50MP0003786_premature_aging0.82023639
51MP0002735_abnormal_chemical_nociception0.78232807
52MP0000049_abnormal_middle_ear0.76537480
53MP0006036_abnormal_mitochondrial_physio0.75066905
54MP0001756_abnormal_urination0.74318191
55MP0003121_genomic_imprinting0.73007118
56MP0002332_abnormal_exercise_endurance0.72662419
57MP0004036_abnormal_muscle_relaxation0.72350037
58MP0001905_abnormal_dopamine_level0.72337023
59MP0000026_abnormal_inner_ear0.71691065
60MP0003638_abnormal_response/metabolism_0.68896150
61MP0001666_abnormal_nutrient_absorption0.67531820
62MP0005636_abnormal_mineral_homeostasis0.66468904
63MP0001835_abnormal_antigen_presentation0.65488123
64MP0009046_muscle_twitch0.60126238
65MP0002733_abnormal_thermal_nociception0.59584364
66MP0001485_abnormal_pinna_reflex0.59172642
67MP0008789_abnormal_olfactory_epithelium0.57061683
68MP0000372_irregular_coat_pigmentation0.56806418
69MP0000249_abnormal_blood_vessel0.56239014
70MP0005376_homeostasis/metabolism_phenot0.55672988
71MP0005332_abnormal_amino_acid0.54942533
72MP0002736_abnormal_nociception_after0.54430054
73MP0009765_abnormal_xenobiotic_induced0.54403136
74MP0002822_catalepsy0.53157140
75MP0003936_abnormal_reproductive_system0.52593228
76MP0004085_abnormal_heartbeat0.50459161
77MP0005319_abnormal_enzyme/_coenzyme0.49416097
78MP0005535_abnormal_body_temperature0.48975545
79MP0002127_abnormal_cardiovascular_syste0.48735607
80MP0005253_abnormal_eye_physiology0.48558899
81MP0003879_abnormal_hair_cell0.47945792
82MP0009384_cardiac_valve_regurgitation0.45927811
83MP0004142_abnormal_muscle_tone0.45845477
84MP0003942_abnormal_urinary_system0.43740677
85MP0004957_abnormal_blastocyst_morpholog0.43701546
86MP0000343_altered_response_to0.43478106
87MP0002229_neurodegeneration0.43444319
88MP0002163_abnormal_gland_morphology0.43357738
89MP0003950_abnormal_plasma_membrane0.42921112
90MP0000313_abnormal_cell_death0.41570087
91MP0005166_decreased_susceptibility_to0.41244547
92MP0001970_abnormal_pain_threshold0.40795750
93MP0005551_abnormal_eye_electrophysiolog0.40629488
94MP0003693_abnormal_embryo_hatching0.39433405
95MP0000230_abnormal_systemic_arterial0.38588476
96MP0005075_abnormal_melanosome_morpholog0.38238303
97MP0000639_abnormal_adrenal_gland0.38031208
98MP0003137_abnormal_impulse_conducting0.37928424
99MP0000749_muscle_degeneration0.37457285
100MP0005666_abnormal_adipose_tissue0.37041610

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.39832547
2Male infertility (HP:0003251)5.52573486
3Asymmetric septal hypertrophy (HP:0001670)4.85792684
4Bony spicule pigmentary retinopathy (HP:0007737)4.45448791
5Attenuation of retinal blood vessels (HP:0007843)4.35909866
6Absent/shortened dynein arms (HP:0200106)4.14721724
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.14721724
8Abnormal respiratory motile cilium physiology (HP:0012261)4.05242750
9Infertility (HP:0000789)3.87264024
10Hepatocellular necrosis (HP:0001404)3.86970266
11Abnormal ciliary motility (HP:0012262)3.79412783
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.65237470
13Aplasia/Hypoplasia of the sacrum (HP:0008517)3.64686164
14Congenital, generalized hypertrichosis (HP:0004540)3.54353197
15Renal Fanconi syndrome (HP:0001994)3.52242216
16Abnormal rod and cone electroretinograms (HP:0008323)3.49517367
17Spastic paraparesis (HP:0002313)3.45933281
18Neonatal short-limb short stature (HP:0008921)3.44503455
19Mitochondrial inheritance (HP:0001427)3.41704983
20Bell-shaped thorax (HP:0001591)3.41648603
21Abnormal spermatogenesis (HP:0008669)3.41526359
22Sensory axonal neuropathy (HP:0003390)3.40297933
23Resting tremor (HP:0002322)3.39434548
24Acute necrotizing encephalopathy (HP:0006965)3.16585599
25Nasal polyposis (HP:0100582)3.15461603
26Hepatic necrosis (HP:0002605)3.14744560
27Aplasia/Hypoplasia of the earlobes (HP:0009906)3.08228808
28Abnormality of macular pigmentation (HP:0008002)3.07897697
29Abnormal respiratory motile cilium morphology (HP:0005938)2.95627564
30Abnormal respiratory epithelium morphology (HP:0012253)2.95627564
31Hyperkalemia (HP:0002153)2.95511976
32Enlarged epiphyses (HP:0010580)2.94841094
33Cone-rod dystrophy (HP:0000548)2.91252815
34Hypoplastic ischia (HP:0003175)2.88634037
35Azoospermia (HP:0000027)2.88164766
36Acute encephalopathy (HP:0006846)2.85501740
37Myokymia (HP:0002411)2.77031191
38Facial shape deformation (HP:0011334)2.74430050
39Potter facies (HP:0002009)2.74430050
40Increased CSF lactate (HP:0002490)2.72524908
41Progressive macrocephaly (HP:0004481)2.71654884
42Generalized aminoaciduria (HP:0002909)2.68111234
43Flattened epiphyses (HP:0003071)2.67809309
44Abnormal mitochondria in muscle tissue (HP:0008316)2.67557757
45Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.53985296
46Subacute progressive viral hepatitis (HP:0006572)2.53752156
47Epiphyseal dysplasia (HP:0002656)2.52371023
48Hypoplasia of the thymus (HP:0000778)2.49504337
49Abnormality of the ischium (HP:0003174)2.45845501
50Absent epiphyses (HP:0010577)2.42411312
51Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.42411312
52Abnormality of the nasal mucosa (HP:0000433)2.40169861
53Cutaneous melanoma (HP:0012056)2.38432240
54Optic disc pallor (HP:0000543)2.35874443
55Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.35186936
56Tubulointerstitial nephritis (HP:0001970)2.34041275
57Natal tooth (HP:0000695)2.30841480
583-Methylglutaconic aciduria (HP:0003535)2.30116197
59Rhinitis (HP:0012384)2.20264798
60Abnormal auditory evoked potentials (HP:0006958)2.17915700
61Retinal dysplasia (HP:0007973)2.17296154
62Abnormality of renal resorption (HP:0011038)2.16466106
63Facial cleft (HP:0002006)2.11575540
64Abnormal urine output (HP:0012590)2.10634659
65Tetany (HP:0001281)2.09166312
66Hypoalphalipoproteinemia (HP:0003233)2.06661265
67Abnormality of T cell physiology (HP:0011840)2.03039344
68Glycosuria (HP:0003076)2.01799605
69Abnormality of urine glucose concentration (HP:0011016)2.01799605
70Progressive sensorineural hearing impairment (HP:0000408)1.99325522
71Unilateral renal agenesis (HP:0000122)1.98218240
72Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.94799421
73Emotional lability (HP:0000712)1.92651276
74Chronic hepatic failure (HP:0100626)1.91285784
75Abnormality of the epiphysis of the femoral head (HP:0010574)1.88395073
76Abnormality of dental color (HP:0011073)1.86762736
77Stage 5 chronic kidney disease (HP:0003774)1.86713177
78Chronic bronchitis (HP:0004469)1.84110232
79Flat capital femoral epiphysis (HP:0003370)1.82939486
80Short ribs (HP:0000773)1.82868599
81Chronic diarrhea (HP:0002028)1.82133455
82Micronodular cirrhosis (HP:0001413)1.82106915
83Seborrheic dermatitis (HP:0001051)1.81100850
84Amniotic constriction ring (HP:0009775)1.79653480
85Abnormality of placental membranes (HP:0011409)1.79653480
86Abnormality of potassium homeostasis (HP:0011042)1.78811333
87Abnormality of renal excretion (HP:0011036)1.78062796
88Sclerocornea (HP:0000647)1.76395905
89Horizontal nystagmus (HP:0000666)1.76355251
90Round ear (HP:0100830)1.75478805
91Respiratory failure (HP:0002878)1.75209151
92Abnormality of the vertebral endplates (HP:0005106)1.73576489
93Hypertriglyceridemia (HP:0002155)1.73398569
94Abnormal drinking behavior (HP:0030082)1.73304002
95Polydipsia (HP:0001959)1.73304002
96Renal dysplasia (HP:0000110)1.73005626
97Abnormality of femoral epiphyses (HP:0006499)1.72819545
98Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.72819545
99Leukodystrophy (HP:0002415)1.71279423
100Polyuria (HP:0000103)1.69134277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.06920193
2TESK15.69726927
3DDR24.21381970
4INSRR3.57728187
5MAP4K23.49295567
6ARAF2.98237488
7MAP3K122.68197172
8MST1R2.58406092
9PLK22.15862072
10PIK3CG2.12267228
11VRK22.10287166
12TESK22.07264631
13MYLK1.98392135
14CDK191.92920611
15STK381.89404728
16STK38L1.78687593
17NME21.73611521
18ABL21.45436573
19PTK2B1.40037286
20CDK71.34808897
21PNCK1.31695794
22PIM21.31677578
23MAPK151.29370123
24WNK11.25167368
25OXSR11.18821320
26BMPR21.16057584
27ILK1.15913706
28PRKD31.14975813
29BRD41.14698040
30PBK1.13643679
31FRK1.13234715
32PAK41.11126055
33CDK31.04786270
34ROCK11.03321134
35BRAF1.03079626
36EPHA21.02926264
37STK161.01619421
38MAP3K110.98319135
39WNK40.97038163
40LATS20.96886762
41PDPK10.93690328
42MOS0.84032827
43MET0.82079860
44STK390.74274548
45PDK10.73933415
46MAP3K90.72601006
47DYRK1B0.71957869
48NEK60.70326374
49DAPK30.68380690
50IRAK30.68375769
51MAP3K130.65815781
52LMTK20.62385099
53CDK11A0.60661207
54ERBB40.56368297
55UHMK10.54601323
56CDK80.53870880
57EIF2AK10.53489044
58MUSK0.51721765
59MAP3K80.49918420
60PRKG10.49349945
61PHKG20.47959797
62PHKG10.47959797
63NEK20.47417121
64RPS6KA20.46083196
65SRPK10.45297879
66IKBKB0.45032566
67CHEK20.44010784
68LATS10.43054655
69CAMK1G0.42909776
70PAK10.42741196
71ERBB30.41851659
72BUB10.40656374
73SIK20.40643100
74PRKG20.40613821
75MAP2K70.39925206
76AURKA0.38540479
77ZAK0.38033649
78CDK40.37664220
79PLK10.36840236
80CDK10.36250473
81BRSK10.34816561
82LIMK10.34619843
83ROCK20.34566663
84VRK10.33350145
85PASK0.32719258
86CDK140.31599630
87CAMK2G0.31060182
88BCR0.27133766
89RPS6KA50.26828326
90DAPK10.25753867
91RPS6KL10.24342689
92RPS6KC10.24342689
93KDR0.23922512
94RPS6KA60.22467609
95CDK120.21288180
96TAOK20.21204872
97RPS6KA10.21178866
98ATR0.19898517
99CDK150.19813392
100PKN10.19343467

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.52402922
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.43381019
3Ribosome_Homo sapiens_hsa030103.83042838
4Parkinsons disease_Homo sapiens_hsa050123.35291465
5Proteasome_Homo sapiens_hsa030503.20413462
6Huntingtons disease_Homo sapiens_hsa050163.09415750
7Cardiac muscle contraction_Homo sapiens_hsa042602.96409818
8Alzheimers disease_Homo sapiens_hsa050102.93640224
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.81010316
10Autoimmune thyroid disease_Homo sapiens_hsa053202.71641662
11Allograft rejection_Homo sapiens_hsa053302.71581435
12Graft-versus-host disease_Homo sapiens_hsa053322.56865365
13Fatty acid biosynthesis_Homo sapiens_hsa000612.51613983
14Viral myocarditis_Homo sapiens_hsa054162.29981396
15Type I diabetes mellitus_Homo sapiens_hsa049402.24542063
16Olfactory transduction_Homo sapiens_hsa047402.17713318
17Homologous recombination_Homo sapiens_hsa034402.10719117
18Antigen processing and presentation_Homo sapiens_hsa046121.97870893
19DNA replication_Homo sapiens_hsa030301.96752718
20Mismatch repair_Homo sapiens_hsa034301.84450252
21RNA transport_Homo sapiens_hsa030131.79447757
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66617500
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40852030
24Base excision repair_Homo sapiens_hsa034101.40154375
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37263659
26Spliceosome_Homo sapiens_hsa030401.32195119
27Asthma_Homo sapiens_hsa053101.25213411
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19637990
29Fat digestion and absorption_Homo sapiens_hsa049751.16936605
30Fanconi anemia pathway_Homo sapiens_hsa034601.05468364
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.00158614
32Nucleotide excision repair_Homo sapiens_hsa034200.99494726
33RNA degradation_Homo sapiens_hsa030180.96640600
34Pyrimidine metabolism_Homo sapiens_hsa002400.95544127
35Bladder cancer_Homo sapiens_hsa052190.93879908
36Sulfur metabolism_Homo sapiens_hsa009200.93030830
37Intestinal immune network for IgA production_Homo sapiens_hsa046720.92253299
38Phenylalanine metabolism_Homo sapiens_hsa003600.91837896
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80357384
40Arginine and proline metabolism_Homo sapiens_hsa003300.80206706
41Taste transduction_Homo sapiens_hsa047420.77832620
42Salivary secretion_Homo sapiens_hsa049700.75624918
43Vibrio cholerae infection_Homo sapiens_hsa051100.75424374
44RNA polymerase_Homo sapiens_hsa030200.74300365
45Endocytosis_Homo sapiens_hsa041440.74010322
46Protein export_Homo sapiens_hsa030600.73581530
47Purine metabolism_Homo sapiens_hsa002300.72338548
48Butanoate metabolism_Homo sapiens_hsa006500.71150670
49Synaptic vesicle cycle_Homo sapiens_hsa047210.70590839
50Systemic lupus erythematosus_Homo sapiens_hsa053220.68445609
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66059125
52Metabolic pathways_Homo sapiens_hsa011000.62687895
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60927562
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60268922
55Basal transcription factors_Homo sapiens_hsa030220.59958188
56Ether lipid metabolism_Homo sapiens_hsa005650.59293575
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57188084
58Toxoplasmosis_Homo sapiens_hsa051450.56114022
59p53 signaling pathway_Homo sapiens_hsa041150.55858272
60Linoleic acid metabolism_Homo sapiens_hsa005910.55679332
61Legionellosis_Homo sapiens_hsa051340.54148029
62Collecting duct acid secretion_Homo sapiens_hsa049660.50616547
63Tyrosine metabolism_Homo sapiens_hsa003500.49604978
64Influenza A_Homo sapiens_hsa051640.47159458
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.46595559
66Oocyte meiosis_Homo sapiens_hsa041140.43908728
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.42202203
68Fatty acid degradation_Homo sapiens_hsa000710.42019398
69Fatty acid elongation_Homo sapiens_hsa000620.39080785
70Rheumatoid arthritis_Homo sapiens_hsa053230.38276797
71Herpes simplex infection_Homo sapiens_hsa051680.37891781
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.37374437
73Retinol metabolism_Homo sapiens_hsa008300.37210556
74Protein digestion and absorption_Homo sapiens_hsa049740.35136357
75Phagosome_Homo sapiens_hsa041450.34611420
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33669302
77Alcoholism_Homo sapiens_hsa050340.33003580
78Viral carcinogenesis_Homo sapiens_hsa052030.31383819
79Type II diabetes mellitus_Homo sapiens_hsa049300.30084378
80Biosynthesis of amino acids_Homo sapiens_hsa012300.28886084
81Folate biosynthesis_Homo sapiens_hsa007900.28199031
82Phototransduction_Homo sapiens_hsa047440.26038118
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23838099
84Epstein-Barr virus infection_Homo sapiens_hsa051690.23012640
85N-Glycan biosynthesis_Homo sapiens_hsa005100.22140629
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20878123
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19717195
88Glutathione metabolism_Homo sapiens_hsa004800.18144749
89Morphine addiction_Homo sapiens_hsa050320.17336190
90Arginine biosynthesis_Homo sapiens_hsa002200.16621705
91ECM-receptor interaction_Homo sapiens_hsa045120.16596861
92Renin-angiotensin system_Homo sapiens_hsa046140.15938079
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.15115674
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14930496
95Fatty acid metabolism_Homo sapiens_hsa012120.13801010
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.12173384
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11788834
98Calcium signaling pathway_Homo sapiens_hsa040200.10435809
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.08137407
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.07382482

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