SPANXN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents one of several duplicated family members that are located on chromosome X. This gene family encodes proteins that play a role in spermiogenesis. These proteins represent a specific subgroup of cancer/testis-associated antigens, and they may be candidates for tumor vaccines. This family member belongs to a subgroup of related genes that are present in all primates and rats and mice, and thus, it represents one of the ancestral family members. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.61747412
2microtubule depolymerization (GO:0007019)9.23914063
3DNA packaging (GO:0006323)9.15265097
4response to pheromone (GO:0019236)8.75400276
5sperm capacitation (GO:0048240)8.64869214
6plasma membrane fusion (GO:0045026)8.46547817
7spermatid development (GO:0007286)7.97004826
8single strand break repair (GO:0000012)7.76294084
9spermatid nucleus differentiation (GO:0007289)7.67222494
10protein targeting to Golgi (GO:0000042)7.58021321
11sperm-egg recognition (GO:0035036)7.44986511
12establishment of protein localization to Golgi (GO:0072600)7.32745374
13protein polyglutamylation (GO:0018095)7.30014417
14microtubule polymerization or depolymerization (GO:0031109)7.26209204
15retrograde transport, vesicle recycling within Golgi (GO:0000301)6.99795660
16multicellular organism reproduction (GO:0032504)6.95389548
17binding of sperm to zona pellucida (GO:0007339)6.88949876
18negative regulation of inclusion body assembly (GO:0090084)6.53303897
19reproduction (GO:0000003)6.47156187
20rRNA methylation (GO:0031167)6.46971721
21calcium ion-dependent exocytosis (GO:0017156)6.28957572
22spermatogenesis (GO:0007283)6.21334440
23male gamete generation (GO:0048232)6.19616039
24cell-cell recognition (GO:0009988)6.07360499
25sexual reproduction (GO:0019953)6.05200288
26axonemal dynein complex assembly (GO:0070286)5.89446531
27phosphatidylethanolamine biosynthetic process (GO:0006646)5.82231362
28microtubule severing (GO:0051013)5.75723102
29gamete generation (GO:0007276)5.70768045
30centriole replication (GO:0007099)5.69375953
31rRNA modification (GO:0000154)5.60198767
32protein localization to Golgi apparatus (GO:0034067)5.43926676
33phosphatidylethanolamine metabolic process (GO:0046337)5.31386383
34cellular ketone body metabolic process (GO:0046950)5.11484160
35regulation of cilium movement (GO:0003352)5.03306480
36cilium or flagellum-dependent cell motility (GO:0001539)4.92866533
37centriole assembly (GO:0098534)4.89265767
38regulation of centriole replication (GO:0046599)4.88141749
39positive regulation of Rab GTPase activity (GO:0032851)4.85820699
40regulation of Rab GTPase activity (GO:0032313)4.85820699
41single fertilization (GO:0007338)4.82605754
42motile cilium assembly (GO:0044458)4.64392026
43regulation of inclusion body assembly (GO:0090083)4.64018505
44germ cell development (GO:0007281)4.62767638
45multicellular organismal reproductive process (GO:0048609)4.54718996
46chromatin silencing (GO:0006342)4.52711185
47ketone body metabolic process (GO:1902224)4.49989514
48cellular process involved in reproduction in multicellular organism (GO:0022412)4.35357877
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.35350053
50seminiferous tubule development (GO:0072520)4.32114678
51epithelial cilium movement (GO:0003351)4.16506413
52fertilization (GO:0009566)4.15979729
53RNA destabilization (GO:0050779)4.15526270
54regulation of transcription involved in cell fate commitment (GO:0060850)4.11271429
55cell wall macromolecule catabolic process (GO:0016998)4.05356984
56nucleus organization (GO:0006997)4.04017096
57piRNA metabolic process (GO:0034587)4.03200854
58glycerol ether metabolic process (GO:0006662)3.99242443
59microtubule nucleation (GO:0007020)3.88010313
60negative regulation of Rho protein signal transduction (GO:0035024)3.85951499
61coenzyme catabolic process (GO:0009109)3.82401776
62cell wall macromolecule metabolic process (GO:0044036)3.80214526
63ether metabolic process (GO:0018904)3.68960403
64protein depolymerization (GO:0051261)3.67040672
65cilium movement (GO:0003341)3.64818620
66regulation of microtubule-based movement (GO:0060632)3.60015610
67multicellular organismal movement (GO:0050879)3.56320282
68musculoskeletal movement (GO:0050881)3.56320282
69DNA methylation involved in gamete generation (GO:0043046)3.53037208
70glomerular visceral epithelial cell development (GO:0072015)3.34138151
71histone H3-K9 demethylation (GO:0033169)3.29259821
72organic cation transport (GO:0015695)3.28691686
73polyamine biosynthetic process (GO:0006596)3.26919922
74male meiosis I (GO:0007141)3.25376971
75male meiosis (GO:0007140)3.19938903
76glomerular epithelial cell development (GO:0072310)3.18889305
77receptor recycling (GO:0001881)3.13335017
78peptidyl-threonine dephosphorylation (GO:0035970)3.09528289
79multicellular organismal development (GO:0007275)3.08043612
80DNA conformation change (GO:0071103)3.05054770
81negative regulation of gene expression, epigenetic (GO:0045814)2.98785638
82nucleosome disassembly (GO:0006337)2.97722119
83protein-DNA complex disassembly (GO:0032986)2.97722119
84response to acidic pH (GO:0010447)2.94890274
85membrane protein intracellular domain proteolysis (GO:0031293)2.94867453
86cellular response to pH (GO:0071467)2.94360251
87histone exchange (GO:0043486)2.93476680
88cerebral cortex neuron differentiation (GO:0021895)2.92555243
89negative regulation of histone methylation (GO:0031061)2.90674060
90intra-Golgi vesicle-mediated transport (GO:0006891)2.89760748
91cell recognition (GO:0008037)2.88599223
92regulation of interleukin-13 production (GO:0032656)2.84690498
93regulation of meiosis I (GO:0060631)2.83884005
94mesenchymal cell differentiation involved in renal system development (GO:2001012)2.81967335
95mesenchymal cell differentiation involved in kidney development (GO:0072161)2.81967335
96detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.78127462
97cranial nerve morphogenesis (GO:0021602)2.73073076
98acrosome reaction (GO:0007340)11.6498360
99sperm motility (GO:0030317)11.2435730
100fusion of sperm to egg plasma membrane (GO:0007342)11.1020696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.43947520
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.20505886
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.61649098
4FUS_26573619_Chip-Seq_HEK293_Human2.48465041
5TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48416434
6POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.48416434
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42773829
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40215546
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.34242377
10EZH2_22144423_ChIP-Seq_EOC_Human2.32414449
11CBP_20019798_ChIP-Seq_JUKART_Human2.19787181
12IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.19787181
13ERA_21632823_ChIP-Seq_H3396_Human2.01470720
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.01111860
15UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.96806430
16EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.90553357
17RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.90253275
18RAC3_21632823_ChIP-Seq_H3396_Human1.88372817
19NANOG_20526341_ChIP-Seq_ESCs_Human1.86393475
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.83392895
21ELF1_20517297_ChIP-Seq_JURKAT_Human1.82613945
22ER_23166858_ChIP-Seq_MCF-7_Human1.81845148
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.81198656
24AUTS2_25519132_ChIP-Seq_293T-REX_Human1.78151711
25ZNF274_21170338_ChIP-Seq_K562_Hela1.73535543
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.73207268
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.71542853
28SMAD4_21741376_ChIP-Seq_EPCs_Human1.69586853
29TAF2_19829295_ChIP-Seq_ESCs_Human1.68586797
30* MYC_19829295_ChIP-Seq_ESCs_Human1.65934571
31VDR_22108803_ChIP-Seq_LS180_Human1.64398505
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.64325985
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.62623820
34AR_25329375_ChIP-Seq_VCAP_Human1.62513757
35PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.61653084
36P300_19829295_ChIP-Seq_ESCs_Human1.54929044
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54845864
38OCT4_20526341_ChIP-Seq_ESCs_Human1.53630596
39ERG_20517297_ChIP-Seq_VCAP_Human1.51422831
40YY1_22570637_ChIP-Seq_MALME-3M_Human1.50403852
41TDRD3_21172665_ChIP-Seq_MCF-7_Human1.48679830
42E2F1_20622854_ChIP-Seq_HELA_Human1.47220180
43CTCF_27219007_Chip-Seq_Bcells_Human1.46579609
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.46058108
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45193574
46TP53_18474530_ChIP-ChIP_U2OS_Human1.45159010
47BCL6_27268052_Chip-Seq_Bcells_Human1.43903564
48DROSHA_22980978_ChIP-Seq_HELA_Human1.39672745
49CTCF_20526341_ChIP-Seq_ESCs_Human1.38356490
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.37865504
51HNFA_21074721_ChIP-Seq_CACO-2_Human1.36814715
52NANOG_19829295_ChIP-Seq_ESCs_Human1.36448065
53SOX2_19829295_ChIP-Seq_ESCs_Human1.36448065
54CBX2_22325352_ChIP-Seq_293T-Rex_Human1.36423684
55TAF15_26573619_Chip-Seq_HEK293_Human1.35659921
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34775446
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32762621
58TP63_22573176_ChIP-Seq_HFKS_Human1.31297976
59SMAD3_21741376_ChIP-Seq_ESCs_Human1.30983250
60BCOR_27268052_Chip-Seq_Bcells_Human1.29987057
61RBPJ_21746931_ChIP-Seq_IB4_Human1.29458984
62PHF8_20622854_ChIP-Seq_HELA_Human1.29323113
63ETV1_20927104_ChIP-Seq_GIST48_Human1.29310914
64P300_27268052_Chip-Seq_Bcells_Human1.27280826
65CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.26669818
66KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.26659305
67RUNX2_22187159_ChIP-Seq_PCA_Human1.26529606
68SMC4_20622854_ChIP-Seq_HELA_Human1.25666028
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24951179
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24483314
71STAT3_23295773_ChIP-Seq_U87_Human1.23093834
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.21523300
73P68_20966046_ChIP-Seq_HELA_Human1.21209848
74NFYB_21822215_ChIP-Seq_K562_Human1.21157620
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20740832
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.20740832
77CEBPB_22108803_ChIP-Seq_LS180_Human1.18575674
78SOX2_22085726_ChIP-Seq_NPCs_Mouse1.16597723
79FOXH1_21741376_ChIP-Seq_EPCs_Human1.15569631
80SMAD4_21799915_ChIP-Seq_A2780_Human1.15469358
81SMAD4_21741376_ChIP-Seq_HESCs_Human1.15416972
82P53_21459846_ChIP-Seq_SAOS-2_Human1.13780452
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13516678
84P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11757793
85PHF8_20622853_ChIP-Seq_HELA_Human1.11697370
86HOXB7_26014856_ChIP-Seq_BT474_Human1.10003111
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09751473
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09185520
89SMRT_27268052_Chip-Seq_Bcells_Human1.08609156
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07240842
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07147362
92AR_21572438_ChIP-Seq_LNCaP_Human1.05456633
93TBL1_22424771_ChIP-Seq_293T_Human1.05214565
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03756015
95E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02877899
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.01928906
97SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01914630
98GATA6_21074721_ChIP-Seq_CACO-2_Human1.01794840
99NFYA_21822215_ChIP-Seq_K562_Human0.99834935
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99126130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.56249332
2MP0003878_abnormal_ear_physiology4.56249332
3MP0003698_abnormal_male_reproductive4.36725868
4MP0003011_delayed_dark_adaptation4.35361747
5MP0005670_abnormal_white_adipose4.21075856
6MP0001929_abnormal_gametogenesis3.90018049
7MP0005083_abnormal_biliary_tract2.90891795
8MP0001348_abnormal_lacrimal_gland2.88130011
9MP0003718_maternal_effect2.61577462
10MP0002161_abnormal_fertility/fecundity2.43552807
11MP0003646_muscle_fatigue2.40000174
12MP0002234_abnormal_pharynx_morphology2.38500115
13MP0000678_abnormal_parathyroid_gland2.33353346
14MP0005379_endocrine/exocrine_gland_phen2.28639104
15MP0002210_abnormal_sex_determination2.02659447
16MP0008877_abnormal_DNA_methylation2.01015324
17MP0005410_abnormal_fertilization11.3759848
18MP0001145_abnormal_male_reproductive1.67216238
19MP0002132_abnormal_respiratory_system1.63012327
20MP0000653_abnormal_sex_gland1.55782299
21MP0005084_abnormal_gallbladder_morpholo1.49886162
22MP0005253_abnormal_eye_physiology1.37591603
23MP0005310_abnormal_salivary_gland1.34169364
24MP0002282_abnormal_trachea_morphology1.32207472
25MP0002249_abnormal_larynx_morphology1.28613590
26MP0001486_abnormal_startle_reflex1.27017034
27MP0009053_abnormal_anal_canal1.20626164
28MP0005551_abnormal_eye_electrophysiolog1.18384151
29MP0005395_other_phenotype1.17502766
30MP0004510_myositis1.16076446
31MP0000534_abnormal_ureter_morphology1.13503317
32MP0002928_abnormal_bile_duct1.12228199
33MP0005423_abnormal_somatic_nervous1.10164143
34MP0004859_abnormal_synaptic_plasticity1.09437941
35MP0001485_abnormal_pinna_reflex1.09312716
36MP0002127_abnormal_cardiovascular_syste1.09156707
37MP0002138_abnormal_hepatobiliary_system1.08659416
38MP0008995_early_reproductive_senescence1.00243605
39MP0002638_abnormal_pupillary_reflex0.98575163
40MP0005365_abnormal_bile_salt0.97145232
41MP0005085_abnormal_gallbladder_physiolo0.93893130
42MP0001765_abnormal_ion_homeostasis0.92177592
43MP0001963_abnormal_hearing_physiology0.91607816
44MP0000026_abnormal_inner_ear0.91031692
45MP0001879_abnormal_lymphatic_vessel0.90371295
46MP0001764_abnormal_homeostasis0.88683191
47MP0004742_abnormal_vestibular_system0.86730963
48MP0003693_abnormal_embryo_hatching0.85680366
49MP0000049_abnormal_middle_ear0.81976513
50MP0003077_abnormal_cell_cycle0.80491683
51MP0001968_abnormal_touch/_nociception0.78714665
52MP0004957_abnormal_blastocyst_morpholog0.78274224
53MP0000955_abnormal_spinal_cord0.77840618
54MP0010368_abnormal_lymphatic_system0.75940988
55MP0002735_abnormal_chemical_nociception0.75141101
56MP0002229_neurodegeneration0.75082280
57MP0005451_abnormal_body_composition0.74337299
58MP0003879_abnormal_hair_cell0.71816061
59MP0002653_abnormal_ependyma_morphology0.68610245
60MP0006072_abnormal_retinal_apoptosis0.67403505
61MP0000681_abnormal_thyroid_gland0.65825238
62MP0009115_abnormal_fat_cell0.65450255
63MP0006292_abnormal_olfactory_placode0.64147517
64MP0000516_abnormal_urinary_system0.62371594
65MP0005367_renal/urinary_system_phenotyp0.62371594
66MP0002160_abnormal_reproductive_system0.61084383
67MP0001905_abnormal_dopamine_level0.60283106
68MP0005391_vision/eye_phenotype0.60119028
69MP0005248_abnormal_Harderian_gland0.59708517
70MP0003137_abnormal_impulse_conducting0.58428928
71MP0002067_abnormal_sensory_capabilities0.56251272
72MP0004085_abnormal_heartbeat0.55196073
73MP0005623_abnormal_meninges_morphology0.54765294
74MP0002733_abnormal_thermal_nociception0.54445547
75MP0003936_abnormal_reproductive_system0.53678699
76MP0003119_abnormal_digestive_system0.53354871
77MP0001529_abnormal_vocalization0.52727689
78MP0002572_abnormal_emotion/affect_behav0.51554976
79MP0005167_abnormal_blood-brain_barrier0.51063736
80MP0003699_abnormal_female_reproductive0.49365573
81MP0009697_abnormal_copulation0.49172282
82MP0000569_abnormal_digit_pigmentation0.47657974
83MP0001666_abnormal_nutrient_absorption0.47494271
84MP0002557_abnormal_social/conspecific_i0.46974516
85MP0002932_abnormal_joint_morphology0.46834751
86MP0005647_abnormal_sex_gland0.45656539
87MP0001299_abnormal_eye_distance/0.44416913
88MP0002272_abnormal_nervous_system0.43356326
89MP0008961_abnormal_basal_metabolism0.43210597
90MP0005666_abnormal_adipose_tissue0.42802596
91MP0004484_altered_response_of0.41719121
92MP0000566_synostosis0.40635447
93MP0001293_anophthalmia0.39035167
94MP0005636_abnormal_mineral_homeostasis0.38833129
95MP0009384_cardiac_valve_regurgitation0.38604611
96MP0000249_abnormal_blood_vessel0.37655851
97MP0002752_abnormal_somatic_nervous0.37625006
98MP0002269_muscular_atrophy0.36451543
99MP0008569_lethality_at_weaning0.36286925
100MP0008789_abnormal_olfactory_epithelium0.35812576

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.57085621
2Absent/shortened dynein arms (HP:0200106)5.77379581
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.77379581
4Chronic hepatic failure (HP:0100626)5.25993992
5Attenuation of retinal blood vessels (HP:0007843)5.06912766
6Bony spicule pigmentary retinopathy (HP:0007737)5.06113770
7Tubulointerstitial nephritis (HP:0001970)4.91254500
8Azoospermia (HP:0000027)4.53327222
9Abnormal spermatogenesis (HP:0008669)4.50877577
10Resting tremor (HP:0002322)4.49646609
11Asymmetric septal hypertrophy (HP:0001670)4.48380403
12Abnormal respiratory motile cilium physiology (HP:0012261)4.42286008
13Abnormal ciliary motility (HP:0012262)4.31964076
14Hyperkalemia (HP:0002153)4.27839073
15Abnormal respiratory motile cilium morphology (HP:0005938)4.17045752
16Abnormal respiratory epithelium morphology (HP:0012253)4.17045752
17Infertility (HP:0000789)4.04663736
18Male infertility (HP:0003251)4.02575512
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.98806350
20Hypoplastic ischia (HP:0003175)3.95603407
21Bell-shaped thorax (HP:0001591)3.79100737
22Cone-rod dystrophy (HP:0000548)3.78946920
23Abnormality of macular pigmentation (HP:0008002)3.76781514
24Abnormal rod and cone electroretinograms (HP:0008323)3.75910986
25Nasal polyposis (HP:0100582)3.54311374
26Enlarged epiphyses (HP:0010580)3.52816487
27Nephronophthisis (HP:0000090)3.48614272
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.48384209
29Abnormality of the ischium (HP:0003174)3.46226980
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.42516787
31Potter facies (HP:0002009)3.23927886
32Facial shape deformation (HP:0011334)3.23927886
33Impulsivity (HP:0100710)3.09850261
34Progressive sensorineural hearing impairment (HP:0000408)3.02700678
35Generalized aminoaciduria (HP:0002909)2.97927323
36Abnormality of the nasal mucosa (HP:0000433)2.97567758
37Stage 5 chronic kidney disease (HP:0003774)2.87048345
38Abnormality of the renal medulla (HP:0100957)2.85305964
39Rhinitis (HP:0012384)2.76709471
40Hypoplasia of the thymus (HP:0000778)2.76610874
41Unilateral renal agenesis (HP:0000122)2.75487972
42Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.75407463
43Postural instability (HP:0002172)2.74014860
44Amelogenesis imperfecta (HP:0000705)2.73934392
45Abnormality of potassium homeostasis (HP:0011042)2.58087493
46Abnormal urine output (HP:0012590)2.56805605
47Hypoalphalipoproteinemia (HP:0003233)2.56006279
48Truncal obesity (HP:0001956)2.55960725
49Progressive cerebellar ataxia (HP:0002073)2.51564986
50Portal hypertension (HP:0001409)2.48646136
51Menstrual irregularities (HP:0000858)2.45229379
52Renal dysplasia (HP:0000110)2.41770429
53Abnormality of the aortic arch (HP:0012303)2.35296117
54Tubulointerstitial abnormality (HP:0001969)2.34773762
55Abnormality of the costochondral junction (HP:0000919)2.34079402
56Renovascular hypertension (HP:0100817)2.32705695
57Hand muscle atrophy (HP:0009130)2.29221998
58Abnormality of dental color (HP:0011073)2.25452367
59Flattened epiphyses (HP:0003071)2.25428597
60Abnormal drinking behavior (HP:0030082)2.25253699
61Polydipsia (HP:0001959)2.25253699
62Abnormality of the hepatic vasculature (HP:0006707)2.24661682
63Abnormality of renal excretion (HP:0011036)2.20287814
64Chronic bronchitis (HP:0004469)2.19244261
65Intellectual disability, moderate (HP:0002342)2.19040324
66Double outlet right ventricle (HP:0001719)2.19020104
67Congenital malformation of the right heart (HP:0011723)2.19020104
68Osteomalacia (HP:0002749)2.18401011
69Horizontal nystagmus (HP:0000666)2.14586898
70Polyuria (HP:0000103)2.13085916
71True hermaphroditism (HP:0010459)2.10344521
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09889450
73Insulin-resistant diabetes mellitus (HP:0000831)2.03399570
74Bronchiectasis (HP:0002110)2.01854315
75Muscle fiber atrophy (HP:0100295)1.99157689
76Abnormality of the parathyroid morphology (HP:0011766)1.97678208
77Abnormality of the epiphysis of the femoral head (HP:0010574)1.95928320
78Abnormality of the pubic bones (HP:0003172)1.95266756
79Absent epiphyses (HP:0010577)1.93959306
80Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.93959306
81Abnormality of the neuromuscular junction (HP:0003398)1.91142620
82Fatigable weakness (HP:0003473)1.91142620
83Volvulus (HP:0002580)1.88830750
84Occipital encephalocele (HP:0002085)1.86712570
85Photophobia (HP:0000613)1.84182821
86Tubular atrophy (HP:0000092)1.83274428
87Type 2 muscle fiber atrophy (HP:0003554)1.82654289
88Hypophosphatemic rickets (HP:0004912)1.81973928
89Tetany (HP:0001281)1.81837575
90Hyponatremia (HP:0002902)1.81797425
91Flat capital femoral epiphysis (HP:0003370)1.81706710
92Focal segmental glomerulosclerosis (HP:0000097)1.81630545
93Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.81591746
94Abnormality of femoral epiphyses (HP:0006499)1.81591746
95Progressive hearing impairment (HP:0001730)1.81169999
96Pancreatic fibrosis (HP:0100732)1.79788724
97Renal Fanconi syndrome (HP:0001994)1.77228441
98Hyperuricemia (HP:0002149)1.76599290
99Increased purine levels (HP:0004368)1.76599290
100Ventricular tachycardia (HP:0004756)1.72363541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.19102516
2TESK16.28820805
3DDR24.19111236
4INSRR3.94040114
5PNCK3.68324129
6MAP4K23.36711218
7PLK23.03097188
8BRD42.95415757
9STK382.61015275
10CAMK1G2.48370690
11PRKD32.15697441
12STK38L2.14370752
13PIK3CG1.93491908
14MAPK151.83146722
15MST1R1.65255475
16NEK61.63727818
17WNK11.63502853
18NME11.61692157
19PTK2B1.52836470
20MAP3K91.33828002
21CDK71.30037940
22PDPK11.22898712
23PDK11.14302804
24CDK121.08062604
25BRAF1.05235399
26BRSK21.03538487
27BRSK10.99986535
28MUSK0.90180887
29DYRK1B0.85554494
30DYRK30.83965250
31MET0.80847313
32CAMK1D0.79051614
33ARAF0.77727981
34BMPR1B0.66663075
35PRKAA20.65080608
36LATS10.62672277
37FRK0.60703802
38CAMK10.60217717
39NUAK10.60067293
40STK390.57041311
41PRKG20.56890456
42SIK20.56763957
43TESK20.54466542
44ROCK10.53981155
45PRKG10.53762190
46KSR20.53299882
47MAP3K80.52317325
48CDK40.50296593
49CDK10.49987027
50WNK40.48374436
51UHMK10.47601058
52AKT30.46904664
53CDK190.45710205
54TIE10.45448840
55TAF10.43591345
56CAMK40.42431914
57CDK20.42036616
58RPS6KA10.41844720
59LIMK10.40349532
60CHEK10.40295763
61TRIM280.37382742
62RPS6KA20.37041914
63GSK3B0.36824342
64AURKA0.36753051
65TYRO30.36097510
66MAP2K20.35263896
67NEK20.34721823
68CDK30.33525261
69PRKCG0.33428960
70MARK20.33384118
71MAPK10.32982981
72PLK10.32345690
73MAP3K20.32141386
74MARK10.31206751
75MAP3K40.30619906
76CAMKK20.30500691
77ACVR1B0.29776651
78OXSR10.28728356
79MAP3K110.24608328
80TAOK30.22978047
81MAPK110.22920968
82MAPK140.22909915
83RPS6KA60.22679827
84LATS20.22318522
85MAP2K70.22175943
86MAPK80.21306230
87WNK30.21075756
88RPS6KL10.21056120
89RPS6KC10.21056120
90ABL20.19852161
91PRKCB0.19342734
92MTOR0.18795275
93PRKCZ0.18692258
94MKNK20.17859433
95SGK2230.16659847
96SGK4940.16659847
97MAPK100.16368092
98VRK10.16084903
99STK30.14659649
100NTRK30.14197933

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.22050220
2Fatty acid biosynthesis_Homo sapiens_hsa000616.18932437
3Olfactory transduction_Homo sapiens_hsa047404.03363800
4Butanoate metabolism_Homo sapiens_hsa006502.60054624
5RNA transport_Homo sapiens_hsa030132.37153167
6Glycerophospholipid metabolism_Homo sapiens_hsa005641.81224749
7Taste transduction_Homo sapiens_hsa047421.75898656
8Dorso-ventral axis formation_Homo sapiens_hsa043201.75020100
9Phototransduction_Homo sapiens_hsa047441.61519957
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.56429704
11Basal transcription factors_Homo sapiens_hsa030221.52472995
12Fatty acid degradation_Homo sapiens_hsa000711.48671956
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.46584166
14Antigen processing and presentation_Homo sapiens_hsa046121.45984108
15Selenocompound metabolism_Homo sapiens_hsa004501.43502665
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42906574
17Arginine and proline metabolism_Homo sapiens_hsa003301.42890458
18Phenylalanine metabolism_Homo sapiens_hsa003601.42390577
19Allograft rejection_Homo sapiens_hsa053301.37924263
20Fatty acid metabolism_Homo sapiens_hsa012121.37355359
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.36273435
22Fanconi anemia pathway_Homo sapiens_hsa034601.36042371
23Type I diabetes mellitus_Homo sapiens_hsa049401.32883794
24Autoimmune thyroid disease_Homo sapiens_hsa053201.31082450
25Inositol phosphate metabolism_Homo sapiens_hsa005621.26425691
26Graft-versus-host disease_Homo sapiens_hsa053321.23963953
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21629925
28Salivary secretion_Homo sapiens_hsa049701.18179774
29Endocytosis_Homo sapiens_hsa041441.15247226
30Type II diabetes mellitus_Homo sapiens_hsa049301.14213925
31Cardiac muscle contraction_Homo sapiens_hsa042601.12371946
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12357684
33Oocyte meiosis_Homo sapiens_hsa041141.11321952
34Retinol metabolism_Homo sapiens_hsa008301.08429223
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04531281
36Viral myocarditis_Homo sapiens_hsa054161.04071049
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01403319
38Purine metabolism_Homo sapiens_hsa002300.98807445
39Protein digestion and absorption_Homo sapiens_hsa049740.96311627
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93290296
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93173478
42Regulation of autophagy_Homo sapiens_hsa041400.92427218
43ABC transporters_Homo sapiens_hsa020100.90300447
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89701845
45Adipocytokine signaling pathway_Homo sapiens_hsa049200.83880937
46Huntingtons disease_Homo sapiens_hsa050160.82436901
47Mismatch repair_Homo sapiens_hsa034300.82213257
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79734177
49Fat digestion and absorption_Homo sapiens_hsa049750.79561030
50Glycerolipid metabolism_Homo sapiens_hsa005610.79520209
51Base excision repair_Homo sapiens_hsa034100.79438795
52Morphine addiction_Homo sapiens_hsa050320.76304242
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74722207
54Calcium signaling pathway_Homo sapiens_hsa040200.72514519
55Hedgehog signaling pathway_Homo sapiens_hsa043400.69564425
56PPAR signaling pathway_Homo sapiens_hsa033200.69193935
57Tyrosine metabolism_Homo sapiens_hsa003500.68432815
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.68052604
59Nucleotide excision repair_Homo sapiens_hsa034200.65019799
60Renin-angiotensin system_Homo sapiens_hsa046140.63996360
61Influenza A_Homo sapiens_hsa051640.63237882
62mRNA surveillance pathway_Homo sapiens_hsa030150.62660884
63Linoleic acid metabolism_Homo sapiens_hsa005910.60280733
64cAMP signaling pathway_Homo sapiens_hsa040240.59198481
65Arginine biosynthesis_Homo sapiens_hsa002200.58651859
66Nicotine addiction_Homo sapiens_hsa050330.57402031
67Nitrogen metabolism_Homo sapiens_hsa009100.56984080
68Synaptic vesicle cycle_Homo sapiens_hsa047210.56746793
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54820506
70DNA replication_Homo sapiens_hsa030300.50789081
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49607994
72beta-Alanine metabolism_Homo sapiens_hsa004100.47122654
73Homologous recombination_Homo sapiens_hsa034400.46550017
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42253500
75Sulfur relay system_Homo sapiens_hsa041220.41786581
76Metabolic pathways_Homo sapiens_hsa011000.40755309
77Insulin secretion_Homo sapiens_hsa049110.40570912
78Bile secretion_Homo sapiens_hsa049760.39192729
79Cell cycle_Homo sapiens_hsa041100.38216296
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32740214
81Circadian entrainment_Homo sapiens_hsa047130.30060012
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29135588
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.28262253
84Pyrimidine metabolism_Homo sapiens_hsa002400.27790643
85MAPK signaling pathway_Homo sapiens_hsa040100.26856261
86RNA degradation_Homo sapiens_hsa030180.26177155
87Pancreatic secretion_Homo sapiens_hsa049720.24875723
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23472948
89Non-homologous end-joining_Homo sapiens_hsa034500.23072111
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22368892
91Viral carcinogenesis_Homo sapiens_hsa052030.22254682
92Chemical carcinogenesis_Homo sapiens_hsa052040.21657915
93Tight junction_Homo sapiens_hsa045300.21276317
94Herpes simplex infection_Homo sapiens_hsa051680.21061213
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21013107
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.20899563
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20004084
98Gastric acid secretion_Homo sapiens_hsa049710.19615057
99Estrogen signaling pathway_Homo sapiens_hsa049150.19562042
100Circadian rhythm_Homo sapiens_hsa047100.19462928

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