SPANXN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents one of several duplicated family members that are located on the X chromosome. This gene family encodes proteins that play a role in spermiogenesis. These proteins represent a specific subgroup of cancer/testis-associated antigens, and they may be candidates for tumor vaccines. This family member belongs to a subgroup of related genes that are present in all primates and rats and mice, and thus, it represents one of the ancestral family members. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.97884011
2reproduction (GO:0000003)9.86300619
3spermatid development (GO:0007286)9.63246290
4axonemal dynein complex assembly (GO:0070286)9.58567427
5motile cilium assembly (GO:0044458)9.40819891
6cilium or flagellum-dependent cell motility (GO:0001539)8.98695753
7regulation of cilium movement (GO:0003352)8.30341541
8cilium movement (GO:0003341)8.15377212
9single fertilization (GO:0007338)7.64651542
10sperm capacitation (GO:0048240)7.42800729
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.39704759
12male meiosis (GO:0007140)7.10861723
13synaptonemal complex assembly (GO:0007130)7.06892983
14synaptonemal complex organization (GO:0070193)6.98963026
15spermatogenesis (GO:0007283)6.53618229
16male gamete generation (GO:0048232)6.51290186
17piRNA metabolic process (GO:0034587)6.44234042
18microtubule depolymerization (GO:0007019)6.39543675
19fertilization (GO:0009566)6.38799466
20organic cation transport (GO:0015695)6.38656705
21negative regulation of inclusion body assembly (GO:0090084)6.37196064
22gamete generation (GO:0007276)5.99009949
23spermatid nucleus differentiation (GO:0007289)5.61796557
24calcium ion-dependent exocytosis (GO:0017156)5.56954094
25regulation of inclusion body assembly (GO:0090083)5.36689153
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.36597888
27germ cell development (GO:0007281)5.29079631
28cell recognition (GO:0008037)5.21962660
29ventricular system development (GO:0021591)5.19626398
30microtubule severing (GO:0051013)4.99478440
31chromosome organization involved in meiosis (GO:0070192)4.95463805
32glycerol ether metabolic process (GO:0006662)4.88054811
33chromosome condensation (GO:0030261)4.83051148
34regulation of microtubule-based movement (GO:0060632)4.80885409
35multicellular organismal reproductive process (GO:0048609)4.71281612
36sexual reproduction (GO:0019953)4.60534134
37DNA packaging (GO:0006323)4.51335485
38ether metabolic process (GO:0018904)4.50683996
39male meiosis I (GO:0007141)4.40445938
40seminiferous tubule development (GO:0072520)4.40005985
41DNA methylation involved in gamete generation (GO:0043046)4.35880245
42single strand break repair (GO:0000012)4.33042772
43protein K11-linked deubiquitination (GO:0035871)4.13610790
44meiotic nuclear division (GO:0007126)4.10597453
45monoubiquitinated protein deubiquitination (GO:0035520)4.06050448
46chaperone-mediated protein complex assembly (GO:0051131)4.04448978
47sequestering of actin monomers (GO:0042989)3.95815790
48left/right pattern formation (GO:0060972)3.82900912
49genitalia morphogenesis (GO:0035112)3.82335057
50multicellular organismal development (GO:0007275)3.81269104
51protein polyglutamylation (GO:0018095)3.46479815
52interferon-gamma secretion (GO:0072643)3.46202873
53meiosis I (GO:0007127)3.44066149
54glycolytic process (GO:0006096)3.37800620
55protein localization to cilium (GO:0061512)3.25836594
56microtubule polymerization or depolymerization (GO:0031109)3.24421976
57polyol catabolic process (GO:0046174)3.20731182
58synapsis (GO:0007129)3.14816452
59regulation of spindle checkpoint (GO:0090231)3.09386546
60positive regulation of macrophage activation (GO:0043032)3.06750620
61alditol metabolic process (GO:0019400)3.02438480
62nucleoside diphosphate phosphorylation (GO:0006165)3.01457031
63meiotic cell cycle (GO:0051321)2.99810992
64centriole assembly (GO:0098534)2.99141335
65cilium organization (GO:0044782)2.92947761
66GTP biosynthetic process (GO:0006183)2.92139000
67carnitine transport (GO:0015879)2.87243208
68amino-acid betaine transport (GO:0015838)2.87243208
69cellular component assembly involved in morphogenesis (GO:0010927)2.82583410
70cilium assembly (GO:0042384)2.82310692
71nucleus organization (GO:0006997)2.80269918
72protein refolding (GO:0042026)2.76555019
73lactate metabolic process (GO:0006089)2.73548581
74cilium morphogenesis (GO:0060271)2.72534279
75carnitine transmembrane transport (GO:1902603)2.71909059
76microtubule-based movement (GO:0007018)2.70628961
77meiotic cell cycle process (GO:1903046)2.68125021
78intraciliary transport (GO:0042073)2.66667713
79glycerol metabolic process (GO:0006071)2.63144060
80UTP biosynthetic process (GO:0006228)2.58481653
81RNA localization (GO:0006403)2.55652562
82mitotic sister chromatid cohesion (GO:0007064)2.53190630
83peptidyl-glutamic acid modification (GO:0018200)2.51490139
84polyamine biosynthetic process (GO:0006596)2.49394616
85cell redox homeostasis (GO:0045454)2.42677318
86negative regulation of organelle assembly (GO:1902116)2.42540921
87chromatin silencing (GO:0006342)2.42354794
88regulation of cilium assembly (GO:1902017)2.40342850
89UTP metabolic process (GO:0046051)2.38027631
90cell wall macromolecule metabolic process (GO:0044036)14.6737285
91cell wall macromolecule catabolic process (GO:0016998)14.6737285
92sperm motility (GO:0030317)13.9555143
93fusion of sperm to egg plasma membrane (GO:0007342)13.7217771
94acrosome assembly (GO:0001675)12.6375679
95acrosome reaction (GO:0007340)11.9521012
96sperm-egg recognition (GO:0035036)11.9178759
97multicellular organism reproduction (GO:0032504)11.3651961
98binding of sperm to zona pellucida (GO:0007339)10.8272905
99cell-cell recognition (GO:0009988)10.6808100
100plasma membrane fusion (GO:0045026)10.4481917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.29269567
2EZH2_22144423_ChIP-Seq_EOC_Human4.53881338
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.35187696
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.54711495
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.75198925
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.72269729
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.56891082
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.56079870
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.40835988
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35606718
11EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.11841321
12VDR_22108803_ChIP-Seq_LS180_Human2.07624051
13GATA1_26923725_Chip-Seq_HPCs_Mouse1.99816763
14KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.96762856
15ZNF274_21170338_ChIP-Seq_K562_Hela1.93572307
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.90426949
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89312404
18STAT1_17558387_ChIP-Seq_HELA_Human1.82208804
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80550898
20CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.78416138
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77292960
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.74834219
23TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.73107418
24RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.71397825
25KAP1_22055183_ChIP-Seq_ESCs_Mouse1.67607872
26KDM2B_26808549_Chip-Seq_REH_Human1.65033605
27MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63970175
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62871340
29TAL1_26923725_Chip-Seq_HPCs_Mouse1.62378946
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60853582
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60467963
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57966415
33GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53077834
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.52746820
35GATA3_21867929_ChIP-Seq_CD8_Mouse1.51271137
36SOX2_22085726_ChIP-Seq_NPCs_Mouse1.46546738
37FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44895100
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44147353
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.43698028
40P53_22387025_ChIP-Seq_ESCs_Mouse1.43126360
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39913037
42CBP_20019798_ChIP-Seq_JUKART_Human1.39913037
43CRX_20693478_ChIP-Seq_RETINA_Mouse1.39487526
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38064943
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38064943
46OCT4_18555785_Chip-Seq_ESCs_Mouse1.37270538
47CMYC_18555785_Chip-Seq_ESCs_Mouse1.36621636
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35183163
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.33312910
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32949357
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32018431
52GATA3_21867929_ChIP-Seq_TH1_Mouse1.31844308
53FLI1_21867929_ChIP-Seq_TH2_Mouse1.30422605
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30216945
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.29536103
56REST_21632747_ChIP-Seq_MESCs_Mouse1.28937106
57LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28623417
58P300_18555785_Chip-Seq_ESCs_Mouse1.28153255
59P53_21459846_ChIP-Seq_SAOS-2_Human1.25255087
60EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24745640
61SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24397849
62KLF4_18555785_Chip-Seq_ESCs_Mouse1.21958735
63RNF2_27304074_Chip-Seq_NSC_Mouse1.21470758
64OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20958301
65GF1_26923725_Chip-Seq_HPCs_Mouse1.18578303
66TAF15_26573619_Chip-Seq_HEK293_Human1.17712762
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17240539
68ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16651764
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16379771
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16281255
71CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14277640
72PU1_27457419_Chip-Seq_LIVER_Mouse1.13605271
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.13401793
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.12651327
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.12153151
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11687574
77SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11551866
78ESET_19884257_ChIP-Seq_ESCs_Mouse1.10834449
79SOX2_18555785_Chip-Seq_ESCs_Mouse1.10680943
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10131506
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09861131
82FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07928508
83CTCF_18555785_Chip-Seq_ESCs_Mouse1.06987938
84RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03470834
85SPI1_26923725_Chip-Seq_HPCs_Mouse1.02489061
86RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02440587
87SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99793063
88ZFX_18555785_Chip-Seq_ESCs_Mouse0.98583128
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98343844
90ERG_20517297_ChIP-Seq_VCAP_Human0.97740914
91KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.97605983
92GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95694957
93CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95362620
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94936473
95SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94815716
96RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93004676
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92936781
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90048263
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89428813
100MYC_27129775_Chip-Seq_CORNEA_Mouse0.89300544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04277813
2MP0001929_abnormal_gametogenesis5.53099628
3MP0008877_abnormal_DNA_methylation4.11600421
4MP0002210_abnormal_sex_determination3.39713136
5MP0002161_abnormal_fertility/fecundity3.23551083
6MP0001145_abnormal_male_reproductive2.88356665
7MP0002653_abnormal_ependyma_morphology2.76959380
8MP0005670_abnormal_white_adipose2.66325312
9MP0000653_abnormal_sex_gland2.51824418
10MP0005410_abnormal_fertilization16.3324319
11MP0002160_abnormal_reproductive_system1.86137834
12MP0003011_delayed_dark_adaptation1.79518319
13MP0005623_abnormal_meninges_morphology1.71371851
14MP0003646_muscle_fatigue1.39762805
15MP0004233_abnormal_muscle_weight1.29086311
16MP0001765_abnormal_ion_homeostasis1.15992499
17MP0005647_abnormal_sex_gland1.15032496
18MP0001984_abnormal_olfaction1.12440462
19MP0009046_muscle_twitch1.11226946
20MP0002282_abnormal_trachea_morphology1.03094942
21MP0008058_abnormal_DNA_repair1.01077635
22MP0008995_early_reproductive_senescence0.97586893
23MP0005389_reproductive_system_phenotype0.96595784
24MP0004019_abnormal_vitamin_homeostasis0.75957182
25MP0002928_abnormal_bile_duct0.66251720
26MP0000751_myopathy0.61766757
27MP0009697_abnormal_copulation0.59525528
28MP0004036_abnormal_muscle_relaxation0.58661028
29MP0002736_abnormal_nociception_after0.57384724
30MP0005551_abnormal_eye_electrophysiolog0.57342230
31MP0005636_abnormal_mineral_homeostasis0.56967738
32MP0009278_abnormal_bone_marrow0.56929612
33MP0005253_abnormal_eye_physiology0.55761548
34MP0002234_abnormal_pharynx_morphology0.55165338
35MP0010094_abnormal_chromosome_stability0.54048426
36MP0000569_abnormal_digit_pigmentation0.51142275
37MP0005397_hematopoietic_system_phenotyp0.50207598
38MP0001545_abnormal_hematopoietic_system0.50207598
39MP0001324_abnormal_eye_pigmentation0.47241400
40MP0005423_abnormal_somatic_nervous0.45251471
41MP0002139_abnormal_hepatobiliary_system0.44356231
42MP0006036_abnormal_mitochondrial_physio0.43914856
43MP0001968_abnormal_touch/_nociception0.42176871
44MP0001293_anophthalmia0.41714527
45MP0005666_abnormal_adipose_tissue0.41346717
46MP0001348_abnormal_lacrimal_gland0.40729783
47MP0003786_premature_aging0.39957790
48MP0003699_abnormal_female_reproductive0.39339653
49MP0003950_abnormal_plasma_membrane0.38587579
50MP0002132_abnormal_respiratory_system0.38416498
51MP0005391_vision/eye_phenotype0.38316255
52MP0003115_abnormal_respiratory_system0.37684782
53MP0008057_abnormal_DNA_replication0.37389556
54MP0002269_muscular_atrophy0.36672415
55MP0003633_abnormal_nervous_system0.35525745
56MP0005377_hearing/vestibular/ear_phenot0.35127871
57MP0003878_abnormal_ear_physiology0.35127871
58MP0003329_amyloid_beta_deposits0.33336646
59MP0001764_abnormal_homeostasis0.32833741
60MP0004133_heterotaxia0.32371603
61MP0001119_abnormal_female_reproductive0.31675364
62MP0005646_abnormal_pituitary_gland0.31104972
63MP0002138_abnormal_hepatobiliary_system0.30803231
64MP0000358_abnormal_cell_content/0.29681804
65MP0005451_abnormal_body_composition0.29026279
66MP0003787_abnormal_imprinting0.28829632
67MP0000579_abnormal_nail_morphology0.26644389
68MP0003631_nervous_system_phenotype0.25939444
69MP0005365_abnormal_bile_salt0.25853166
70MP0002169_no_abnormal_phenotype0.24685739
71MP0002873_normal_phenotype0.24455365
72MP0003252_abnormal_bile_duct0.22594217
73MP0001529_abnormal_vocalization0.22578735
74MP0008875_abnormal_xenobiotic_pharmacok0.22533372
75MP0002092_abnormal_eye_morphology0.22263111
76MP0000462_abnormal_digestive_system0.21561057
77MP0009115_abnormal_fat_cell0.20430872
78MP0004811_abnormal_neuron_physiology0.20086288
79MP0002572_abnormal_emotion/affect_behav0.19501212
80MP0002229_neurodegeneration0.19309833
81MP0002152_abnormal_brain_morphology0.18023439
82MP0002102_abnormal_ear_morphology0.17890238
83MP0002971_abnormal_brown_adipose0.17745835
84MP0003183_abnormal_peptide_metabolism0.17448390
85MP0004808_abnormal_hematopoietic_stem0.17406638
86MP0008872_abnormal_physiological_respon0.17292657
87MP0006072_abnormal_retinal_apoptosis0.17015336
88MP0004270_analgesia0.16108599
89MP0000313_abnormal_cell_death0.15771665
90MP0003861_abnormal_nervous_system0.15355127
91MP0001486_abnormal_startle_reflex0.15260320
92MP0005195_abnormal_posterior_eye0.15062860
93MP0001986_abnormal_taste_sensitivity0.14983240
94MP0004145_abnormal_muscle_electrophysio0.14960510
95MP0002133_abnormal_respiratory_system0.14945965
96MP0005388_respiratory_system_phenotype0.14945965
97MP0005319_abnormal_enzyme/_coenzyme0.13945759
98MP0003942_abnormal_urinary_system0.13938625
99MP0003948_abnormal_gas_homeostasis0.13889515
100MP0000604_amyloidosis0.13754627

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.56936563
2Abnormal respiratory motile cilium morphology (HP:0005938)9.10532764
3Abnormal respiratory epithelium morphology (HP:0012253)9.10532764
4Abnormal ciliary motility (HP:0012262)7.91462685
5Rhinitis (HP:0012384)7.40292112
6Chronic bronchitis (HP:0004469)7.35333123
7Infertility (HP:0000789)6.59600987
8Nasal polyposis (HP:0100582)6.29534073
9Abnormality of the nasal mucosa (HP:0000433)5.16674591
10Male infertility (HP:0003251)4.48328484
11Bronchitis (HP:0012387)4.37455990
12Bronchiectasis (HP:0002110)4.31482636
13Nephronophthisis (HP:0000090)4.11873017
14Recurrent sinusitis (HP:0011108)3.62041630
15Abnormal spermatogenesis (HP:0008669)3.37645689
16Recurrent otitis media (HP:0000403)3.20439844
17Abnormality of the renal medulla (HP:0100957)3.11333987
18Tubulointerstitial nephritis (HP:0001970)2.87866614
19Medial flaring of the eyebrow (HP:0010747)2.79111095
20Tubular atrophy (HP:0000092)2.65611348
21Molar tooth sign on MRI (HP:0002419)2.60879182
22Abnormality of midbrain morphology (HP:0002418)2.60879182
23Decreased central vision (HP:0007663)2.48403264
24Tubulointerstitial abnormality (HP:0001969)2.43571840
25Recurrent bronchitis (HP:0002837)2.38871234
26Postaxial foot polydactyly (HP:0001830)2.24648475
27Azoospermia (HP:0000027)2.19984239
28Dyschromatopsia (HP:0007641)2.17437856
29Gonadotropin excess (HP:0000837)2.02782847
30Absent/shortened dynein arms (HP:0200106)13.4184257
31Dynein arm defect of respiratory motile cilia (HP:0012255)13.4184257
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3376018
33Cholecystitis (HP:0001082)1.99932024
34Abnormal gallbladder physiology (HP:0012438)1.99932024
35Congenital hepatic fibrosis (HP:0002612)1.97694967
36Impulsivity (HP:0100710)1.97385647
37Tubulointerstitial fibrosis (HP:0005576)1.93952508
38Choroideremia (HP:0001139)1.93498953
39Bile duct proliferation (HP:0001408)1.92176077
40Abnormal biliary tract physiology (HP:0012439)1.92176077
41Stage 5 chronic kidney disease (HP:0003774)1.89536039
42Abnormal drinking behavior (HP:0030082)1.87375871
43Polydipsia (HP:0001959)1.87375871
44Abnormality of the renal cortex (HP:0011035)1.81488009
45Fatigue (HP:0012378)1.79013927
46Abnormality of renal excretion (HP:0011036)1.74289073
47Facial cleft (HP:0002006)1.73033028
48Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67052120
49Pancreatic fibrosis (HP:0100732)1.65348988
50Aplasia/Hypoplasia of the lens (HP:0008063)1.65286651
51Rhabdomyolysis (HP:0003201)1.62166976
52Gait imbalance (HP:0002141)1.60163803
53Congenital primary aphakia (HP:0007707)1.59637080
54Abnormality of permanent molar morphology (HP:0011071)1.57649627
55Abnormality of the dental root (HP:0006486)1.57649627
56Taurodontia (HP:0000679)1.57649627
57Cystic liver disease (HP:0006706)1.56400749
58Postaxial hand polydactyly (HP:0001162)1.55957655
59Fibular hypoplasia (HP:0003038)1.51639818
60Sensory axonal neuropathy (HP:0003390)1.51262342
61Asymmetric septal hypertrophy (HP:0001670)1.49583614
62Abnormality of molar (HP:0011077)1.47217427
63Abnormality of molar morphology (HP:0011070)1.47217427
64Abnormality of the dental pulp (HP:0006479)1.46124853
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.45419640
66Oculomotor apraxia (HP:0000657)1.44391847
67Double outlet right ventricle (HP:0001719)1.44203139
68Congenital malformation of the right heart (HP:0011723)1.44203139
69Spastic tetraparesis (HP:0001285)1.43738911
70Microglossia (HP:0000171)1.42767827
71Short ribs (HP:0000773)1.42154019
72True hermaphroditism (HP:0010459)1.41509718
73Renal dysplasia (HP:0000110)1.39012314
74Hemorrhage of the eye (HP:0011885)1.38859673
75Chronic sinusitis (HP:0011109)1.37466111
76Abnormal urine output (HP:0012590)1.37240941
77Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.35220998
78Absent frontal sinuses (HP:0002688)1.34785344
79Vascular calcification (HP:0004934)1.34156036
80Hypoplasia of the capital femoral epiphysis (HP:0003090)1.32763488
81Nephrogenic diabetes insipidus (HP:0009806)1.32093442
82Median cleft lip (HP:0000161)1.30275843
83Chronic hepatic failure (HP:0100626)1.30146509
84Heterotopia (HP:0002282)1.29058360
85Abnormality of dentin (HP:0010299)1.28661143
86Bundle branch block (HP:0011710)1.27414191
87Abnormality of the lower motor neuron (HP:0002366)1.27172648
88Attenuation of retinal blood vessels (HP:0007843)1.25764248
89Poor coordination (HP:0002370)1.25695098
90Genital tract atresia (HP:0001827)1.24359445
91Abnormality of saccadic eye movements (HP:0000570)1.24284135
92Short thorax (HP:0010306)1.23883740
93Nephropathy (HP:0000112)1.23830770
94Neurofibrillary tangles (HP:0002185)1.23206786
95Vaginal atresia (HP:0000148)1.23059477
96Cardiovascular calcification (HP:0011915)1.20598136
97Optic nerve hypoplasia (HP:0000609)1.20580257
98Ventricular fibrillation (HP:0001663)1.19959093
99J-shaped sella turcica (HP:0002680)1.18549440
100Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.17077650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.84809331
2PDK48.84809331
3PDK25.71632075
4TESK15.41569073
5PRKD34.01850366
6ICK3.67732748
7PTK2B2.19517487
8STK392.10896076
9WNK42.03528646
10STK381.72779073
11PDK11.43114334
12PNCK1.40634432
13PKN21.31672542
14NEK21.25098402
15DYRK1B1.23255719
16IRAK10.98054073
17TTK0.80678692
18FLT30.78185951
19LMTK20.77009288
20STK30.75378556
21PDPK10.73884319
22PASK0.73515390
23DYRK30.72964291
24IRAK20.72333096
25STK38L0.71374935
26TYRO30.70974694
27WNK10.70935983
28MAP2K60.62834044
29MAPK150.60934911
30RIPK40.57084025
31PINK10.56996469
32CCNB10.54864632
33EEF2K0.53473881
34MUSK0.45949119
35PAK10.45635015
36CHEK20.45543493
37CLK10.40910079
38PRKCG0.37653443
39TESK20.33692024
40NTRK20.33162847
41PAK20.32420837
42CHEK10.32038871
43CDK120.31965663
44CAMK1G0.30252081
45STK160.26192256
46GRK10.26150858
47FRK0.25097340
48CAMKK10.24998555
49WNK30.24226303
50ATM0.24005875
51MAPKAPK50.21446593
52STK110.21078457
53ATR0.20632130
54PRKCQ0.19189199
55OXSR10.18621595
56PKN10.17702819
57MARK20.16381985
58WEE10.16310107
59MAP3K100.16022062
60PRKG20.15182802
61NEK60.13565932
62PRKCZ0.13274521
63CDK150.12711088
64RPS6KB10.12127421
65PLK10.12016733
66PRKAA10.11173784
67BRSK20.10468833
68CDK180.09598774
69PRKG10.09003959
70MTOR0.08866439
71MAP2K70.08825072
72CSNK2A10.08333437
73ZAP700.07808137
74CDK11A0.07514572
75EIF2AK20.05913707
76CAMK2A0.05760350
77PLK40.05719670
78PRKCA0.04805989
79PRKACG0.04714684
80GSK3B0.04150254
81PRKCB0.04002349
82CSNK2A20.04000939
83CDK140.03711723
84PRKCD0.02741742
85RPS6KA10.02689720
86PDGFRB0.02577838
87CSF1R0.02489685
88YES10.02463422
89BRSK10.02338296
90FGFR20.01796423
91CDK190.01739358
92PRKACA0.01356650
93CSNK1D0.01202883
94LATS10.00671185
95RET0.00531825
96ADRBK2-0.0136610
97GSK3A-0.0123647
98MAPK8-0.0054623
99PAK4-0.0038495
100CDK1-0.0004190

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.60773918
2Vitamin B6 metabolism_Homo sapiens_hsa007504.38722551
3Fatty acid biosynthesis_Homo sapiens_hsa000613.98216088
4Pyruvate metabolism_Homo sapiens_hsa006203.49799943
5Propanoate metabolism_Homo sapiens_hsa006403.05460568
6Pentose phosphate pathway_Homo sapiens_hsa000302.76647278
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.68656436
8Linoleic acid metabolism_Homo sapiens_hsa005912.62256197
9Glucagon signaling pathway_Homo sapiens_hsa049222.61348313
10Selenocompound metabolism_Homo sapiens_hsa004502.55807064
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.48250719
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.14978634
13Basal transcription factors_Homo sapiens_hsa030222.13169715
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.03385114
15Carbohydrate digestion and absorption_Homo sapiens_hsa049732.02699194
16Glycerolipid metabolism_Homo sapiens_hsa005611.92531391
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.90496141
18PPAR signaling pathway_Homo sapiens_hsa033201.76757704
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69813154
20Oocyte meiosis_Homo sapiens_hsa041141.65805179
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.61571053
22Fanconi anemia pathway_Homo sapiens_hsa034601.46532119
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.43483286
24Fructose and mannose metabolism_Homo sapiens_hsa000511.42416411
25Mineral absorption_Homo sapiens_hsa049781.40759090
26Amphetamine addiction_Homo sapiens_hsa050311.40604847
27Cardiac muscle contraction_Homo sapiens_hsa042601.34270675
28Carbon metabolism_Homo sapiens_hsa012001.32288042
29Renin-angiotensin system_Homo sapiens_hsa046141.31323959
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28938352
31Fat digestion and absorption_Homo sapiens_hsa049751.24439438
32Fatty acid degradation_Homo sapiens_hsa000711.21752263
33Fatty acid metabolism_Homo sapiens_hsa012121.21595245
34Ether lipid metabolism_Homo sapiens_hsa005651.17972961
35Purine metabolism_Homo sapiens_hsa002301.16722578
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.15821611
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.14828795
38Renin secretion_Homo sapiens_hsa049241.12195448
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09730485
40Dorso-ventral axis formation_Homo sapiens_hsa043201.04171144
41Glutathione metabolism_Homo sapiens_hsa004801.02698013
42Huntingtons disease_Homo sapiens_hsa050161.02692831
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01883840
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94416350
45mRNA surveillance pathway_Homo sapiens_hsa030150.93738108
46Bile secretion_Homo sapiens_hsa049760.93316830
47Biosynthesis of amino acids_Homo sapiens_hsa012300.90022875
48Chemical carcinogenesis_Homo sapiens_hsa052040.84704126
49Insulin secretion_Homo sapiens_hsa049110.82762175
50Collecting duct acid secretion_Homo sapiens_hsa049660.80057240
51Arachidonic acid metabolism_Homo sapiens_hsa005900.70524613
52Protein digestion and absorption_Homo sapiens_hsa049740.69496311
53Thyroid hormone synthesis_Homo sapiens_hsa049180.68659678
54Long-term potentiation_Homo sapiens_hsa047200.68073721
55Hedgehog signaling pathway_Homo sapiens_hsa043400.66860409
56ABC transporters_Homo sapiens_hsa020100.64867354
57Calcium signaling pathway_Homo sapiens_hsa040200.64431488
58Inositol phosphate metabolism_Homo sapiens_hsa005620.63969965
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63434630
60Antigen processing and presentation_Homo sapiens_hsa046120.62632740
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60502438
62Estrogen signaling pathway_Homo sapiens_hsa049150.59910911
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.58628152
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58461122
65Retinol metabolism_Homo sapiens_hsa008300.57093864
66Systemic lupus erythematosus_Homo sapiens_hsa053220.54029569
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.53735784
68Taste transduction_Homo sapiens_hsa047420.53712370
69Galactose metabolism_Homo sapiens_hsa000520.53114468
70Salivary secretion_Homo sapiens_hsa049700.51565312
71Pancreatic secretion_Homo sapiens_hsa049720.51066510
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47920208
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46802314
74Sulfur metabolism_Homo sapiens_hsa009200.46002626
75Metabolic pathways_Homo sapiens_hsa011000.45698502
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45402430
77RNA transport_Homo sapiens_hsa030130.39421671
78Gastric acid secretion_Homo sapiens_hsa049710.37475367
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37116824
80cAMP signaling pathway_Homo sapiens_hsa040240.35274025
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32483088
82Legionellosis_Homo sapiens_hsa051340.32462160
83Circadian entrainment_Homo sapiens_hsa047130.32419013
84AMPK signaling pathway_Homo sapiens_hsa041520.31356007
85Starch and sucrose metabolism_Homo sapiens_hsa005000.29530394
86Synaptic vesicle cycle_Homo sapiens_hsa047210.29404801
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.29227673
88Endocytosis_Homo sapiens_hsa041440.27193702
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.26780692
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23759625
91Pyrimidine metabolism_Homo sapiens_hsa002400.21136114
92Alcoholism_Homo sapiens_hsa050340.19585770
93Glutamatergic synapse_Homo sapiens_hsa047240.17477112
94Cocaine addiction_Homo sapiens_hsa050300.14643703
95VEGF signaling pathway_Homo sapiens_hsa043700.13804575
96Type II diabetes mellitus_Homo sapiens_hsa049300.12520731
97B cell receptor signaling pathway_Homo sapiens_hsa046620.11850500
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.08351210
99Olfactory transduction_Homo sapiens_hsa047400.07942166
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.06000973

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