SPANXN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA packaging (GO:0006323)9.61030611
2sperm capacitation (GO:0048240)9.08062917
3plasma membrane fusion (GO:0045026)8.95674572
4microtubule depolymerization (GO:0007019)8.56027464
5single strand break repair (GO:0000012)8.55825741
6spermatid nucleus differentiation (GO:0007289)8.46857348
7spermatid development (GO:0007286)7.78335672
8sperm-egg recognition (GO:0035036)7.77784963
9binding of sperm to zona pellucida (GO:0007339)7.47038418
10sexual reproduction (GO:0019953)7.26136829
11rRNA methylation (GO:0031167)6.98020320
12microtubule polymerization or depolymerization (GO:0031109)6.89076957
13negative regulation of inclusion body assembly (GO:0090084)6.85090821
14multicellular organism reproduction (GO:0032504)6.82896179
15calcium ion-dependent exocytosis (GO:0017156)6.76163631
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.71502189
17reproduction (GO:0000003)6.70730871
18cell-cell recognition (GO:0009988)6.39084790
19protein polyglutamylation (GO:0018095)6.19767972
20spermatogenesis (GO:0007283)6.09080095
21male gamete generation (GO:0048232)6.06975323
22axonemal dynein complex assembly (GO:0070286)6.03522607
23cellular ketone body metabolic process (GO:0046950)6.01444994
24protein targeting to Golgi (GO:0000042)5.96733327
25rRNA modification (GO:0000154)5.90573781
26establishment of protein localization to Golgi (GO:0072600)5.72620247
27phosphatidylethanolamine biosynthetic process (GO:0006646)5.68766641
28gamete generation (GO:0007276)5.54240449
29retrograde transport, vesicle recycling within Golgi (GO:0000301)5.53916831
30ketone body metabolic process (GO:1902224)5.30896211
31microtubule severing (GO:0051013)5.29813369
32phosphatidylethanolamine metabolic process (GO:0046337)5.24587969
33regulation of Rab GTPase activity (GO:0032313)5.18234437
34positive regulation of Rab GTPase activity (GO:0032851)5.18234437
35chromatin silencing (GO:0006342)5.11053840
36centriole replication (GO:0007099)5.06577472
37motile cilium assembly (GO:0044458)4.91657115
38regulation of inclusion body assembly (GO:0090083)4.86959915
39single fertilization (GO:0007338)4.77500217
40regulation of cilium movement (GO:0003352)4.63874278
41coenzyme catabolic process (GO:0009109)4.61620996
42centriole assembly (GO:0098534)4.47435933
43multicellular organismal reproductive process (GO:0048609)4.43288562
44germ cell development (GO:0007281)4.42390592
45negative regulation of Rho protein signal transduction (GO:0035024)4.40966827
46cell wall macromolecule catabolic process (GO:0016998)4.40915804
47regulation of transcription involved in cell fate commitment (GO:0060850)4.36887694
48glycerol ether metabolic process (GO:0006662)4.29473710
49protein localization to Golgi apparatus (GO:0034067)4.28336907
50cellular process involved in reproduction in multicellular organism (GO:0022412)4.25277879
51RNA destabilization (GO:0050779)4.22781202
52cell wall macromolecule metabolic process (GO:0044036)4.09998969
53regulation of centriole replication (GO:0046599)4.09669106
54cilium or flagellum-dependent cell motility (GO:0001539)4.06683166
55nucleus organization (GO:0006997)4.06237430
56ether metabolic process (GO:0018904)3.96371197
57fertilization (GO:0009566)3.87254912
58seminiferous tubule development (GO:0072520)3.83486284
59regulation of somitogenesis (GO:0014807)3.60573645
60mesenchymal cell differentiation involved in renal system development (GO:2001012)3.59745241
61mesenchymal cell differentiation involved in kidney development (GO:0072161)3.59745241
62epithelial cilium movement (GO:0003351)3.53008894
63negative regulation of gene expression, epigenetic (GO:0045814)3.51097300
64cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.50695394
65musculoskeletal movement (GO:0050881)3.49280919
66multicellular organismal movement (GO:0050879)3.49280919
67glomerular visceral epithelial cell development (GO:0072015)3.45828659
68cell differentiation involved in metanephros development (GO:0072202)3.45254087
69histone H3-K9 demethylation (GO:0033169)3.36182229
70glomerular epithelial cell development (GO:0072310)3.35313444
71protein-DNA complex disassembly (GO:0032986)3.32955751
72nucleosome disassembly (GO:0006337)3.32955751
73cranial nerve morphogenesis (GO:0021602)3.32508267
74organic cation transport (GO:0015695)3.25448873
75NAD biosynthetic process (GO:0009435)3.25286595
76protein depolymerization (GO:0051261)3.23709910
77regulation of interleukin-13 production (GO:0032656)3.23218978
78peptidyl-threonine dephosphorylation (GO:0035970)3.23174091
79polyamine biosynthetic process (GO:0006596)3.21218164
80peptidyl-proline hydroxylation (GO:0019511)3.17717528
81regulation of T-helper 2 cell differentiation (GO:0045628)3.17453360
82response to acidic pH (GO:0010447)3.16762423
83regulation of microtubule-based movement (GO:0060632)3.16225209
84cerebral cortex neuron differentiation (GO:0021895)3.14615992
85cilium movement (GO:0003341)3.14149523
86DNA conformation change (GO:0071103)3.09458067
87cell recognition (GO:0008037)3.05987551
88cellular response to pH (GO:0071467)3.01843171
89negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.99144313
90homeostasis of number of cells within a tissue (GO:0048873)2.97772666
91tooth mineralization (GO:0034505)2.96315883
92membrane protein intracellular domain proteolysis (GO:0031293)2.90937531
93metanephric mesenchyme development (GO:0072075)2.89090481
94multicellular organismal development (GO:0007275)2.88134379
95pattern specification involved in kidney development (GO:0061004)2.83994941
96acrosome reaction (GO:0007340)12.6081664
97fusion of sperm to egg plasma membrane (GO:0007342)11.7861495
98sperm motility (GO:0030317)11.2554099
99response to pheromone (GO:0019236)10.9197313
100chromosome condensation (GO:0030261)10.1714428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.80414378
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.08911790
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.95741971
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43552046
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.43552046
6ELF1_20517297_ChIP-Seq_JURKAT_Human2.25105357
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22666192
8IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.17274789
9CBP_20019798_ChIP-Seq_JUKART_Human2.17274789
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15330882
11ERA_21632823_ChIP-Seq_H3396_Human2.11784799
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.03526173
13EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.98911740
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94130750
15RAC3_21632823_ChIP-Seq_H3396_Human1.92702388
16RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.89934176
17NANOG_20526341_ChIP-Seq_ESCs_Human1.87104233
18EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.83028718
19WDR5_24793694_ChIP-Seq_LNCAP_Human1.81669112
20FUS_26573619_Chip-Seq_HEK293_Human1.79884433
21CTCF_27219007_Chip-Seq_Bcells_Human1.77452972
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.76992765
23DROSHA_22980978_ChIP-Seq_HELA_Human1.74128740
24E2F1_20622854_ChIP-Seq_HELA_Human1.73791108
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72569566
26BCL6_27268052_Chip-Seq_Bcells_Human1.69433027
27TDRD3_21172665_ChIP-Seq_MCF-7_Human1.68888248
28MYC_19829295_ChIP-Seq_ESCs_Human1.66601280
29TAF2_19829295_ChIP-Seq_ESCs_Human1.66117918
30YY1_22570637_ChIP-Seq_MALME-3M_Human1.65849450
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64033171
32SMC4_20622854_ChIP-Seq_HELA_Human1.59894187
33AUTS2_25519132_ChIP-Seq_293T-REX_Human1.59314735
34CTCF_20526341_ChIP-Seq_ESCs_Human1.57579073
35BCOR_27268052_Chip-Seq_Bcells_Human1.55701306
36ER_23166858_ChIP-Seq_MCF-7_Human1.54974268
37PHF8_20622854_ChIP-Seq_HELA_Human1.54558328
38P68_20966046_ChIP-Seq_HELA_Human1.54278292
39TP53_18474530_ChIP-ChIP_U2OS_Human1.53770673
40TP63_22573176_ChIP-Seq_HFKS_Human1.53386424
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.52052552
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.51518319
43SMAD4_21741376_ChIP-Seq_EPCs_Human1.48292079
44ETV2_25802403_ChIP-Seq_MESCs_Mouse1.46461671
45LXR_22292898_ChIP-Seq_THP-1_Human1.45338600
46OCT4_20526341_ChIP-Seq_ESCs_Human1.44413246
47HNFA_21074721_ChIP-Seq_CACO-2_Human1.40200551
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37975552
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36933785
50CBX2_22325352_ChIP-Seq_293T-Rex_Human1.36105584
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.34746284
52P300_27268052_Chip-Seq_Bcells_Human1.34564093
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33908875
54RUNX_20019798_ChIP-Seq_JUKART_Human1.32337233
55AR_25329375_ChIP-Seq_VCAP_Human1.32298412
56CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.32098343
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31723109
58RBPJ_21746931_ChIP-Seq_IB4_Human1.30513149
59EZH2_22144423_ChIP-Seq_EOC_Human1.29962033
60SMAD3_21741376_ChIP-Seq_ESCs_Human1.29027725
61TAF15_26573619_Chip-Seq_HEK293_Human1.28736668
62KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.25381819
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.25171975
64SOX2_22085726_ChIP-Seq_NPCs_Mouse1.24325876
65ETV1_20927104_ChIP-Seq_GIST48_Human1.24176807
66CEBPB_22108803_ChIP-Seq_LS180_Human1.22876115
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.22484273
68P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.22400036
69P53_21459846_ChIP-Seq_SAOS-2_Human1.21543224
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21398148
71SA1_27219007_Chip-Seq_Bcells_Human1.21103655
72SMAD4_21741376_ChIP-Seq_HESCs_Human1.19063673
73ERG_20517297_ChIP-Seq_VCAP_Human1.18601193
74P300_19829295_ChIP-Seq_ESCs_Human1.18412380
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17844551
76NFYB_21822215_ChIP-Seq_K562_Human1.17641787
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16099821
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15824862
79TBL1_22424771_ChIP-Seq_293T_Human1.14251762
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13363682
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12893976
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.10701577
83ZNF274_21170338_ChIP-Seq_K562_Hela1.09741828
84SMRT_27268052_Chip-Seq_Bcells_Human1.09192096
85PHF8_20622853_ChIP-Seq_HELA_Human1.08932671
86GATA6_21074721_ChIP-Seq_CACO-2_Human1.07593808
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07461456
88RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06518407
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03731580
90RUNX2_22187159_ChIP-Seq_PCA_Human1.02806082
91E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02298685
92NANOG_19829295_ChIP-Seq_ESCs_Human1.02227215
93SOX2_19829295_ChIP-Seq_ESCs_Human1.02227215
94CSB_26484114_Chip-Seq_FIBROBLAST_Human1.01857930
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.00910474
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97956808
97VDR_22108803_ChIP-Seq_LS180_Human0.97597552
98NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97382702
99PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97189430
100* HOXB7_26014856_ChIP-Seq_BT474_Human0.96771144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.90494609
2MP0003878_abnormal_ear_physiology4.90494609
3MP0003698_abnormal_male_reproductive4.35210384
4MP0005670_abnormal_white_adipose4.22320277
5MP0001348_abnormal_lacrimal_gland3.80924626
6MP0001929_abnormal_gametogenesis3.69404680
7MP0000678_abnormal_parathyroid_gland3.03391861
8MP0003011_delayed_dark_adaptation2.83196474
9MP0002161_abnormal_fertility/fecundity2.42384271
10MP0002132_abnormal_respiratory_system2.39638132
11MP0002234_abnormal_pharynx_morphology2.29327771
12MP0003718_maternal_effect2.28071917
13MP0005410_abnormal_fertilization12.5237000
14MP0004510_myositis1.94637640
15MP0003646_muscle_fatigue1.86140181
16MP0005379_endocrine/exocrine_gland_phen1.84769474
17MP0002249_abnormal_larynx_morphology1.83169750
18MP0005423_abnormal_somatic_nervous1.75055431
19MP0009053_abnormal_anal_canal1.65561115
20MP0002282_abnormal_trachea_morphology1.56756713
21MP0002210_abnormal_sex_determination1.44845719
22MP0001486_abnormal_startle_reflex1.44195559
23MP0005310_abnormal_salivary_gland1.43050955
24MP0001485_abnormal_pinna_reflex1.34160666
25MP0004742_abnormal_vestibular_system1.26981675
26MP0001145_abnormal_male_reproductive1.25589787
27MP0005248_abnormal_Harderian_gland1.25241406
28MP0002735_abnormal_chemical_nociception1.23802003
29MP0000534_abnormal_ureter_morphology1.23383213
30MP0001765_abnormal_ion_homeostasis1.22621131
31MP0001968_abnormal_touch/_nociception1.21421754
32MP0002127_abnormal_cardiovascular_syste1.21338706
33MP0000653_abnormal_sex_gland1.17885765
34MP0002138_abnormal_hepatobiliary_system1.15138324
35MP0000681_abnormal_thyroid_gland1.07630166
36MP0004859_abnormal_synaptic_plasticity1.04184085
37MP0005395_other_phenotype1.03446757
38MP0001963_abnormal_hearing_physiology1.02957303
39MP0000026_abnormal_inner_ear0.98129691
40MP0000049_abnormal_middle_ear0.92628325
41MP0003879_abnormal_hair_cell0.90018411
42MP0001879_abnormal_lymphatic_vessel0.88343134
43MP0000516_abnormal_urinary_system0.86569577
44MP0005367_renal/urinary_system_phenotyp0.86569577
45MP0002733_abnormal_thermal_nociception0.85688951
46MP0002229_neurodegeneration0.85491485
47MP0000955_abnormal_spinal_cord0.82363850
48MP0004085_abnormal_heartbeat0.76956587
49MP0005636_abnormal_mineral_homeostasis0.70887898
50MP0005083_abnormal_biliary_tract0.70460489
51MP0008877_abnormal_DNA_methylation0.70424658
52MP0002822_catalepsy0.69511681
53MP0002067_abnormal_sensory_capabilities0.65793890
54MP0005551_abnormal_eye_electrophysiolog0.65264778
55MP0005623_abnormal_meninges_morphology0.65123850
56MP0004484_altered_response_of0.63639754
57MP0005451_abnormal_body_composition0.61494148
58MP0008569_lethality_at_weaning0.61101968
59MP0005375_adipose_tissue_phenotype0.60278252
60MP0000003_abnormal_adipose_tissue0.59739194
61MP0005167_abnormal_blood-brain_barrier0.59670811
62MP0009115_abnormal_fat_cell0.58817930
63MP0005666_abnormal_adipose_tissue0.57712218
64MP0002557_abnormal_social/conspecific_i0.56161235
65MP0001970_abnormal_pain_threshold0.55748069
66MP0001666_abnormal_nutrient_absorption0.54279674
67MP0002653_abnormal_ependyma_morphology0.53363013
68MP0003119_abnormal_digestive_system0.52055049
69MP0004233_abnormal_muscle_weight0.51043769
70MP0008995_early_reproductive_senescence0.50319417
71MP0003137_abnormal_impulse_conducting0.50100748
72MP0000566_synostosis0.49623798
73MP0005253_abnormal_eye_physiology0.49608446
74MP0001984_abnormal_olfaction0.49379011
75MP0000249_abnormal_blood_vessel0.49045070
76MP0002572_abnormal_emotion/affect_behav0.48972199
77MP0009697_abnormal_copulation0.47786150
78MP0006292_abnormal_olfactory_placode0.47291207
79MP0003880_abnormal_central_pattern0.46774682
80MP0002272_abnormal_nervous_system0.45135010
81MP0003077_abnormal_cell_cycle0.44217899
82MP0002734_abnormal_mechanical_nocicepti0.43795745
83MP0008961_abnormal_basal_metabolism0.43719623
84MP0003172_abnormal_lysosome_physiology0.42737406
85MP0005535_abnormal_body_temperature0.41236364
86MP0005408_hypopigmentation0.41116529
87MP0000470_abnormal_stomach_morphology0.41028238
88MP0004036_abnormal_muscle_relaxation0.40242746
89MP0001905_abnormal_dopamine_level0.39055275
90MP0000613_abnormal_salivary_gland0.38796317
91MP0001501_abnormal_sleep_pattern0.38685866
92MP0003936_abnormal_reproductive_system0.37961914
93MP0003942_abnormal_urinary_system0.37731544
94MP0005084_abnormal_gallbladder_morpholo0.37396309
95MP0008789_abnormal_olfactory_epithelium0.37306522
96MP0003699_abnormal_female_reproductive0.36462870
97MP0002928_abnormal_bile_duct0.36086565
98MP0000230_abnormal_systemic_arterial0.34970707
99MP0000467_abnormal_esophagus_morphology0.34955609
100MP0009745_abnormal_behavioral_response0.32410965

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.93868040
2Absent/shortened dynein arms (HP:0200106)5.89788886
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.89788886
4Asymmetric septal hypertrophy (HP:0001670)5.35421991
5Attenuation of retinal blood vessels (HP:0007843)5.26722322
6Bony spicule pigmentary retinopathy (HP:0007737)5.17227471
7Resting tremor (HP:0002322)4.57932485
8Bell-shaped thorax (HP:0001591)4.55590622
9Hypoplastic ischia (HP:0003175)4.55509619
10Abnormal ciliary motility (HP:0012262)4.53847832
11Abnormal respiratory motile cilium physiology (HP:0012261)4.42067884
12Abnormal rod and cone electroretinograms (HP:0008323)4.40803236
13Abnormal respiratory motile cilium morphology (HP:0005938)4.24492346
14Abnormal respiratory epithelium morphology (HP:0012253)4.24492346
15Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.24408763
16Nasal polyposis (HP:0100582)4.16553939
17Enlarged epiphyses (HP:0010580)4.12304273
18Infertility (HP:0000789)4.05707316
19Abnormality of the ischium (HP:0003174)4.01884116
20Male infertility (HP:0003251)3.98463464
21Azoospermia (HP:0000027)3.94122258
22Facial shape deformation (HP:0011334)3.92572717
23Potter facies (HP:0002009)3.92572717
24Tubulointerstitial nephritis (HP:0001970)3.91111075
25Abnormality of macular pigmentation (HP:0008002)3.88724894
26Unilateral renal agenesis (HP:0000122)3.78373396
27Hyperkalemia (HP:0002153)3.75969407
28Abnormal spermatogenesis (HP:0008669)3.72963941
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.70063696
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.69846583
31Chronic hepatic failure (HP:0100626)3.53559695
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.52466258
33Abnormality of the nasal mucosa (HP:0000433)3.37613473
34Double outlet right ventricle (HP:0001719)3.31560578
35Congenital malformation of the right heart (HP:0011723)3.31560578
36Cone-rod dystrophy (HP:0000548)3.26556226
37Impulsivity (HP:0100710)3.08495299
38Abnormality of the aortic arch (HP:0012303)3.08020360
39Renal dysplasia (HP:0000110)2.81730566
40Hypoplasia of the thymus (HP:0000778)2.80975516
41Postural instability (HP:0002172)2.78184821
42Generalized aminoaciduria (HP:0002909)2.73820175
43Abnormal urine output (HP:0012590)2.73785791
44Abnormality of the parathyroid morphology (HP:0011766)2.67040328
45Stage 5 chronic kidney disease (HP:0003774)2.64604119
46Progressive sensorineural hearing impairment (HP:0000408)2.55564761
47Rhinitis (HP:0012384)2.51586915
48Epiphyseal dysplasia (HP:0002656)2.48280453
49Absent epiphyses (HP:0010577)2.47065045
50Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.47065045
51Ventricular tachycardia (HP:0004756)2.46317506
52Flattened epiphyses (HP:0003071)2.43647588
53Abnormality of the costochondral junction (HP:0000919)2.42013561
54Nephronophthisis (HP:0000090)2.41864666
55Amelogenesis imperfecta (HP:0000705)2.40042983
56Abnormality of potassium homeostasis (HP:0011042)2.34413569
57Abnormality of renal excretion (HP:0011036)2.34292533
58Progressive cerebellar ataxia (HP:0002073)2.27637053
59Tetany (HP:0001281)2.26476485
60Abnormality of the pubic bones (HP:0003172)2.26280159
61Hyperthyroidism (HP:0000836)2.24643924
62Abnormality of dental color (HP:0011073)2.23298855
63Abnormality of the epiphysis of the femoral head (HP:0010574)2.22291548
64Polydipsia (HP:0001959)2.19490987
65Abnormal drinking behavior (HP:0030082)2.19490987
66Spastic paraparesis (HP:0002313)2.17330787
67Polyuria (HP:0000103)2.16624432
68Truncal obesity (HP:0001956)2.15565201
69Hypoalphalipoproteinemia (HP:0003233)2.15248710
70Focal segmental glomerulosclerosis (HP:0000097)2.13599095
71Muscle fiber atrophy (HP:0100295)2.12383526
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11765091
73Hyponatremia (HP:0002902)2.11345203
74Sensory axonal neuropathy (HP:0003390)2.09678835
75Osteomalacia (HP:0002749)2.09281470
76Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.08077298
77Abnormality of femoral epiphyses (HP:0006499)2.08077298
78Decreased central vision (HP:0007663)2.06517608
79Abnormal ventriculo-arterial connection (HP:0011563)2.05077568
80Transposition of the great arteries (HP:0001669)2.05077568
81Abnormal connection of the cardiac segments (HP:0011545)2.05077568
82Portal hypertension (HP:0001409)2.04236238
83Abnormality of the renal medulla (HP:0100957)2.02990374
84Hypoparathyroidism (HP:0000829)2.00240243
85Abnormality of the femoral head (HP:0003368)1.97737919
86Abnormality of the neuromuscular junction (HP:0003398)1.97186767
87Fatigable weakness (HP:0003473)1.97186767
88Bronchiectasis (HP:0002110)1.94178734
89Atelectasis (HP:0100750)1.93353978
90Flat capital femoral epiphysis (HP:0003370)1.93077975
91Recurrent corneal erosions (HP:0000495)1.92243927
92Hypophosphatemic rickets (HP:0004912)1.91936446
93Insulin-resistant diabetes mellitus (HP:0000831)1.91773297
94Mixed hearing impairment (HP:0000410)1.90170335
95Widely patent fontanelles and sutures (HP:0004492)1.90144478
96Hypoplastic left heart (HP:0004383)1.89571824
97Bradycardia (HP:0001662)1.88171668
98Amblyopia (HP:0000646)1.87596511
99Abnormality of the hepatic vasculature (HP:0006707)1.84929653
100Short ribs (HP:0000773)1.84045797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.26077644
2TESK16.57999126
3DDR25.60244200
4INSRR4.39761740
5MAP4K24.35629891
6PLK23.08560746
7BRD42.91712040
8STK382.71460776
9MAPK152.36091655
10PNCK2.29521787
11WNK12.07413402
12PRKD32.06482726
13CAMK1G1.92120656
14STK38L1.85495714
15PIK3CG1.77063615
16MST1R1.55179733
17PDPK11.54869850
18PDK11.43055584
19CDK71.41482923
20CDK121.25945338
21KSR21.24800256
22MAP3K91.22527353
23DYRK1B1.21955000
24PTK2B1.13473100
25LATS20.97638004
26NEK60.96677520
27UHMK10.84687734
28MUSK0.82364202
29PRKAA20.77048399
30CAMK1D0.76975014
31MAP3K20.73265953
32PRKG20.72319616
33MAP3K110.69526878
34RPS6KA20.69237021
35BRAF0.66977920
36MAP3K80.64098714
37AKT30.63464805
38PRKG10.62242046
39MAP2K20.61540232
40RPS6KA10.57206954
41ROCK10.54078857
42CDK40.51952262
43WNK40.50274663
44CAMK10.48286071
45LATS10.43710817
46CDK30.42878158
47GSK3B0.42828495
48TYRO30.42203840
49STK390.40824183
50MARK10.40454961
51ARAF0.39776622
52CDK20.39619855
53CAMK40.39199790
54MAPK10.38240646
55CDK10.38163614
56RPS6KC10.37055898
57RPS6KL10.37055898
58PRKCG0.35126497
59MTOR0.34615482
60RPS6KA60.34113099
61BMPR1B0.33384788
62NTRK30.33140020
63PRKCZ0.32425837
64SIK20.32138819
65MAPK80.31600935
66MAP3K10.31587125
67SGK4940.30603534
68SGK2230.30603534
69TIE10.29399504
70CHEK10.27388390
71TESK20.23942546
72MAPK140.21614968
73BRSK10.21346717
74BLK0.20945249
75SGK10.20301449
76MAPK100.19849020
77PRKCB0.19275793
78MARK20.19132037
79MET0.17337821
80AKT10.17012768
81PKN10.15712707
82FER0.15539385
83DYRK30.15274496
84MAP3K40.14571891
85IKBKB0.14332213
86FRK0.13863067
87MAPK110.13183160
88CHUK0.11168999
89ABL20.09153683
90OXSR10.08623363
91PRKACA0.08485014
92MAP3K70.08415237
93MAPK90.07888394
94MAP3K130.07497996
95PRKACB0.06926799
96CAMK2A0.06889117
97PRKAA10.05981640
98ROCK20.05608111
99LMTK20.03173940
100RPS6KA30.02929136

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.69911293
2Fatty acid biosynthesis_Homo sapiens_hsa000615.02693996
3Olfactory transduction_Homo sapiens_hsa047403.82415585
4Butanoate metabolism_Homo sapiens_hsa006502.84139787
5Allograft rejection_Homo sapiens_hsa053302.53628879
6Autoimmune thyroid disease_Homo sapiens_hsa053202.44762310
7Type I diabetes mellitus_Homo sapiens_hsa049402.39080617
8Graft-versus-host disease_Homo sapiens_hsa053322.33868955
9Antigen processing and presentation_Homo sapiens_hsa046122.12052466
10Glycerophospholipid metabolism_Homo sapiens_hsa005641.86731272
11Viral myocarditis_Homo sapiens_hsa054161.79569836
12Taste transduction_Homo sapiens_hsa047421.79256031
13Phenylalanine metabolism_Homo sapiens_hsa003601.71646331
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69987708
15Dorso-ventral axis formation_Homo sapiens_hsa043201.67240064
16Type II diabetes mellitus_Homo sapiens_hsa049301.59788471
17Arginine and proline metabolism_Homo sapiens_hsa003301.56558647
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39513681
19RNA transport_Homo sapiens_hsa030131.37899009
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32409812
21Fatty acid degradation_Homo sapiens_hsa000711.26736431
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23750792
23Endocytosis_Homo sapiens_hsa041441.23125291
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18739378
25Protein digestion and absorption_Homo sapiens_hsa049741.07169794
26Fatty acid metabolism_Homo sapiens_hsa012121.07155516
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05302264
28Salivary secretion_Homo sapiens_hsa049701.03600741
29Cardiac muscle contraction_Homo sapiens_hsa042601.00091332
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96881004
31Phototransduction_Homo sapiens_hsa047440.95584285
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94497416
33Arginine biosynthesis_Homo sapiens_hsa002200.93545219
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92524360
35Influenza A_Homo sapiens_hsa051640.91828248
36Adipocytokine signaling pathway_Homo sapiens_hsa049200.85267640
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84387534
38Oocyte meiosis_Homo sapiens_hsa041140.81998755
39Inositol phosphate metabolism_Homo sapiens_hsa005620.80870453
40cAMP signaling pathway_Homo sapiens_hsa040240.80266590
41Fat digestion and absorption_Homo sapiens_hsa049750.76838675
42Tyrosine metabolism_Homo sapiens_hsa003500.72554620
43Calcium signaling pathway_Homo sapiens_hsa040200.72111230
44Renin-angiotensin system_Homo sapiens_hsa046140.67633736
45Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67357302
46Retinol metabolism_Homo sapiens_hsa008300.66594703
47Morphine addiction_Homo sapiens_hsa050320.66397828
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65827312
49Estrogen signaling pathway_Homo sapiens_hsa049150.65130249
50PPAR signaling pathway_Homo sapiens_hsa033200.62863565
51Hedgehog signaling pathway_Homo sapiens_hsa043400.58201515
52Synaptic vesicle cycle_Homo sapiens_hsa047210.57718506
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55250525
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55047850
55Nicotine addiction_Homo sapiens_hsa050330.53350030
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52061713
57Circadian entrainment_Homo sapiens_hsa047130.50509645
58Glycerolipid metabolism_Homo sapiens_hsa005610.47384362
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.46772400
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.46353580
61Purine metabolism_Homo sapiens_hsa002300.46110019
62ABC transporters_Homo sapiens_hsa020100.46013066
63MAPK signaling pathway_Homo sapiens_hsa040100.45424065
64VEGF signaling pathway_Homo sapiens_hsa043700.44133418
65Insulin secretion_Homo sapiens_hsa049110.43998698
66mRNA surveillance pathway_Homo sapiens_hsa030150.43801291
67Renin secretion_Homo sapiens_hsa049240.42443427
68Basal transcription factors_Homo sapiens_hsa030220.42110417
69Glutamatergic synapse_Homo sapiens_hsa047240.41624063
70Acute myeloid leukemia_Homo sapiens_hsa052210.41617962
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.41592008
72Bile secretion_Homo sapiens_hsa049760.40338269
73Viral carcinogenesis_Homo sapiens_hsa052030.39407132
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38328697
75Gastric acid secretion_Homo sapiens_hsa049710.35829924
76Herpes simplex infection_Homo sapiens_hsa051680.35185841
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34746638
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.33060749
79Tight junction_Homo sapiens_hsa045300.33031513
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28844381
81Serotonergic synapse_Homo sapiens_hsa047260.26485047
82Pancreatic secretion_Homo sapiens_hsa049720.26397795
83Epstein-Barr virus infection_Homo sapiens_hsa051690.26040962
84Legionellosis_Homo sapiens_hsa051340.25708570
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25491767
86Cholinergic synapse_Homo sapiens_hsa047250.23826510
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20138993
88Selenocompound metabolism_Homo sapiens_hsa004500.20039251
89Vitamin B6 metabolism_Homo sapiens_hsa007500.19772802
90ECM-receptor interaction_Homo sapiens_hsa045120.19099149
91Oxytocin signaling pathway_Homo sapiens_hsa049210.17323020
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16821389
93Toxoplasmosis_Homo sapiens_hsa051450.15610515
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15017663
95Prolactin signaling pathway_Homo sapiens_hsa049170.14635390
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.13675673
97Fanconi anemia pathway_Homo sapiens_hsa034600.13135646
98Huntingtons disease_Homo sapiens_hsa050160.13093410
99Adherens junction_Homo sapiens_hsa045200.12301516
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12176468

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