SPARCL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.67733610
2axon ensheathment in central nervous system (GO:0032291)5.61104352
3central nervous system myelination (GO:0022010)5.61104352
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.51725774
5cellular potassium ion homeostasis (GO:0030007)5.46935589
6sodium ion export (GO:0071436)5.30359323
7synaptic vesicle maturation (GO:0016188)5.30168657
8gamma-aminobutyric acid transport (GO:0015812)5.22797585
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.88304756
10vocalization behavior (GO:0071625)4.82968625
11glutamate secretion (GO:0014047)4.70252204
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.65336987
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.64197158
14neuronal action potential propagation (GO:0019227)4.59694443
15synaptic vesicle exocytosis (GO:0016079)4.59641166
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.53761218
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.45427085
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.39905620
19neurotransmitter secretion (GO:0007269)4.38730639
20L-amino acid import (GO:0043092)4.37460486
21regulation of synaptic vesicle exocytosis (GO:2000300)4.37083851
22cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.32890996
23cell communication by electrical coupling (GO:0010644)4.29831860
24potassium ion import (GO:0010107)4.28356557
25regulation of glutamate receptor signaling pathway (GO:1900449)4.26747751
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.12165042
27cellular sodium ion homeostasis (GO:0006883)4.07816721
28regulation of neuronal synaptic plasticity (GO:0048168)4.04043611
29exploration behavior (GO:0035640)4.02458709
30proline transport (GO:0015824)4.02169357
31neurotransmitter-gated ion channel clustering (GO:0072578)4.01929255
32glutamate receptor signaling pathway (GO:0007215)3.98142058
33presynaptic membrane assembly (GO:0097105)3.95424837
34synaptic transmission, glutamatergic (GO:0035249)3.92671434
35regulation of synaptic vesicle transport (GO:1902803)3.90569347
36regulation of synapse structural plasticity (GO:0051823)3.89452974
37amino acid import (GO:0043090)3.86788034
38layer formation in cerebral cortex (GO:0021819)3.79269542
39potassium ion homeostasis (GO:0055075)3.75572409
40long-term memory (GO:0007616)3.72256980
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.71916625
42presynaptic membrane organization (GO:0097090)3.70060112
43neuron cell-cell adhesion (GO:0007158)3.69479549
44neurotransmitter transport (GO:0006836)3.67279911
45protein localization to synapse (GO:0035418)3.62949308
46neuron-neuron synaptic transmission (GO:0007270)3.60718030
47alanine transport (GO:0032328)3.56947951
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.55423059
49response to auditory stimulus (GO:0010996)3.52614148
50glycine transport (GO:0015816)3.49724593
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.48609548
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48192583
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.45446024
54regulation of neurotransmitter levels (GO:0001505)3.43751544
55neuromuscular process controlling posture (GO:0050884)3.42477471
56auditory behavior (GO:0031223)3.42191002
57cell communication involved in cardiac conduction (GO:0086065)3.40241701
58C4-dicarboxylate transport (GO:0015740)3.38410257
59negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.36135714
60gamma-aminobutyric acid signaling pathway (GO:0007214)3.34659813
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.34569727
62cerebellar Purkinje cell differentiation (GO:0021702)3.34513427
63transmission of nerve impulse (GO:0019226)3.34267795
64cGMP-mediated signaling (GO:0019934)3.32994301
65cerebellar granule cell differentiation (GO:0021707)3.32499342
66activation of protein kinase A activity (GO:0034199)3.32380178
67neurotransmitter uptake (GO:0001504)3.29004797
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.28664488
69neuromuscular process controlling balance (GO:0050885)3.28526718
70regulation of voltage-gated calcium channel activity (GO:1901385)3.26185588
71dendritic spine morphogenesis (GO:0060997)3.24040923
72regulation of synaptic plasticity (GO:0048167)3.23692501
73long-term synaptic potentiation (GO:0060291)3.21850496
74regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21841135
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.17752835
76negative regulation of cytosolic calcium ion concentration (GO:0051481)3.17011035
77positive regulation of membrane potential (GO:0045838)3.15410947
78positive regulation of potassium ion transmembrane transport (GO:1901381)3.08157294
79regulation of postsynaptic membrane potential (GO:0060078)3.07550341
80regulation of cardiac muscle cell contraction (GO:0086004)3.07432699
81membrane depolarization during action potential (GO:0086010)3.04144151
82astrocyte differentiation (GO:0048708)3.03483125
83acidic amino acid transport (GO:0015800)3.02834788
84regulation of neurotransmitter secretion (GO:0046928)3.01105359
85positive regulation of dendritic spine development (GO:0060999)3.00150350
86prepulse inhibition (GO:0060134)2.99350456
87detection of calcium ion (GO:0005513)2.98031263
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.97820455
89membrane repolarization (GO:0086009)2.97698079
90regulation of synapse maturation (GO:0090128)2.97227763
91regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.94131455
92dendrite morphogenesis (GO:0048813)2.93717704
93regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.91717205
94regulation of dendritic spine morphogenesis (GO:0061001)2.89770972
95neuronal ion channel clustering (GO:0045161)2.89733287
96regulation of respiratory system process (GO:0044065)2.89714438
97cerebellar Purkinje cell layer development (GO:0021680)2.88583026
98postsynaptic membrane organization (GO:0001941)2.87561498
99synaptic vesicle endocytosis (GO:0048488)2.87169967
100positive regulation of synaptic transmission, GABAergic (GO:0032230)2.86148514
101regulation of neurotransmitter transport (GO:0051588)2.85611399
102long term synaptic depression (GO:0060292)2.84139456
103regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.83207546
104neuron recognition (GO:0008038)2.82553830
105negative regulation of sodium ion transport (GO:0010766)2.82439271
106membrane hyperpolarization (GO:0060081)2.82395024
107positive regulation of synapse maturation (GO:0090129)2.81490799
108positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80332676
109positive regulation of synaptic transmission (GO:0050806)2.80147641
110regulation of vesicle fusion (GO:0031338)2.79642434
111L-glutamate transport (GO:0015813)2.79046823
112membrane depolarization (GO:0051899)2.78453326
113regulation of synaptic transmission (GO:0050804)2.77057901
114innervation (GO:0060384)2.76769354
115mechanosensory behavior (GO:0007638)2.75507896
116positive regulation of potassium ion transport (GO:0043268)2.75482145
117regulation of cell communication by electrical coupling (GO:0010649)2.75064822
118astrocyte development (GO:0014002)2.70362230
119regulation of dendritic spine development (GO:0060998)2.69290896
120regulation of ARF protein signal transduction (GO:0032012)2.63720991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.35806988
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.20645068
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07968096
4GBX2_23144817_ChIP-Seq_PC3_Human2.97983405
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92086077
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78343350
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78343350
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.66765817
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.62549471
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60240799
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60099509
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57279782
13DROSHA_22980978_ChIP-Seq_HELA_Human2.55637192
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47397414
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.44166148
16REST_21632747_ChIP-Seq_MESCs_Mouse2.41149858
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.32280264
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26811645
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.23041672
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19653026
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.18093875
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.17855287
23AR_21572438_ChIP-Seq_LNCaP_Human2.03861146
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.02257070
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.93923024
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84337961
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77268680
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67839293
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.62876516
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.59451642
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54072098
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53242268
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52745140
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51935349
35SMAD4_21799915_ChIP-Seq_A2780_Human1.50635238
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.50159142
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.46279836
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43394728
39* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37890182
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.36918099
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36769901
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33313514
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33072465
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30906079
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27119252
46* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23855287
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23058353
48* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22890843
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.22408582
50WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22221026
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22188294
52* AR_19668381_ChIP-Seq_PC3_Human1.21235741
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.19913660
54* AR_25329375_ChIP-Seq_VCAP_Human1.19519090
55P300_19829295_ChIP-Seq_ESCs_Human1.19148588
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18313034
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16010746
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.14924849
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14764197
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.13194209
61TAF15_26573619_Chip-Seq_HEK293_Human1.13123515
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12621239
63STAT3_23295773_ChIP-Seq_U87_Human1.12325710
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11006240
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10693273
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08935060
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08844112
68RXR_22108803_ChIP-Seq_LS180_Human1.08745812
69ZNF274_21170338_ChIP-Seq_K562_Hela1.08508670
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08129648
71KDM2B_26808549_Chip-Seq_K562_Human1.08109703
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06573084
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06258655
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.06172162
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04786195
76* RING1B_27294783_Chip-Seq_NPCs_Mouse1.04152610
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02954919
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02155468
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01796740
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01361280
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00785952
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00744125
83AHR_22903824_ChIP-Seq_MCF-7_Human1.00714357
84EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00060805
85BCAT_22108803_ChIP-Seq_LS180_Human0.98117839
86ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97205929
87* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97041489
88TP53_16413492_ChIP-PET_HCT116_Human0.96992505
89SMAD4_21741376_ChIP-Seq_HESCs_Human0.96681963
90TCF4_23295773_ChIP-Seq_U87_Human0.96126068
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95969041
92ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95157616
93SMAD3_21741376_ChIP-Seq_HESCs_Human0.93848014
94EP300_21415370_ChIP-Seq_HL-1_Mouse0.93523278
95* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91870263
96THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91419459
97* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91112252
98RUNX2_22187159_ChIP-Seq_PCA_Human0.90747146
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.89392033
100TP53_18474530_ChIP-ChIP_U2OS_Human0.87999324
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86817042
102P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86653338
103RNF2_27304074_Chip-Seq_NSC_Mouse0.86494713
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85589733
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84942066
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84565930
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.83360908
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82872592
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82037541
110TP53_20018659_ChIP-ChIP_R1E_Mouse0.81229973
111* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80781588
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80054022
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79975870
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.79064441
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.78784315
116CTCF_27219007_Chip-Seq_Bcells_Human0.78433771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.09261592
2MP0003880_abnormal_central_pattern4.03662752
3MP0003635_abnormal_synaptic_transmissio3.99503842
4MP0004270_analgesia3.49756526
5MP0009046_muscle_twitch3.43864697
6MP0005423_abnormal_somatic_nervous3.41995922
7MP0009745_abnormal_behavioral_response3.31671184
8MP0002064_seizures3.16471748
9MP0002063_abnormal_learning/memory/cond3.03550569
10MP0001486_abnormal_startle_reflex2.69958972
11MP0001968_abnormal_touch/_nociception2.66241737
12MP0002572_abnormal_emotion/affect_behav2.62463773
13MP0002272_abnormal_nervous_system2.59720099
14MP0002734_abnormal_mechanical_nocicepti2.45243188
15MP0004858_abnormal_nervous_system2.35674964
16MP0004885_abnormal_endolymph2.33681914
17MP0001501_abnormal_sleep_pattern2.30972700
18MP0008569_lethality_at_weaning2.28112813
19MP0009780_abnormal_chondrocyte_physiolo2.24304630
20MP0002822_catalepsy2.11016973
21MP0001440_abnormal_grooming_behavior2.10434094
22MP0002736_abnormal_nociception_after2.07740443
23MP0003329_amyloid_beta_deposits2.03961774
24MP0003690_abnormal_glial_cell2.03541870
25MP0002067_abnormal_sensory_capabilities1.95568666
26MP0005646_abnormal_pituitary_gland1.95381492
27MP0005167_abnormal_blood-brain_barrier1.87641602
28MP0002733_abnormal_thermal_nociception1.78924758
29MP0001970_abnormal_pain_threshold1.74747143
30MP0003633_abnormal_nervous_system1.71234269
31MP0002909_abnormal_adrenal_gland1.66018637
32MP0002557_abnormal_social/conspecific_i1.63293109
33MP0002735_abnormal_chemical_nociception1.55427962
34MP0005386_behavior/neurological_phenoty1.49013723
35MP0004924_abnormal_behavior1.49013723
36MP0000778_abnormal_nervous_system1.43583186
37MP0002184_abnormal_innervation1.42607000
38MP0000955_abnormal_spinal_cord1.40029899
39MP0004811_abnormal_neuron_physiology1.38795629
40MP0003631_nervous_system_phenotype1.38145606
41MP0000751_myopathy1.36751473
42MP0001502_abnormal_circadian_rhythm1.34623287
43MP0002066_abnormal_motor_capabilities/c1.33935594
44MP0003075_altered_response_to1.32425005
45MP0001984_abnormal_olfaction1.30140642
46MP0003879_abnormal_hair_cell1.29644294
47MP0004142_abnormal_muscle_tone1.29227506
48MP0005645_abnormal_hypothalamus_physiol1.29156702
49MP0004215_abnormal_myocardial_fiber1.28275566
50* MP0002882_abnormal_neuron_morphology1.25513370
51MP0003787_abnormal_imprinting1.15083522
52MP0000013_abnormal_adipose_tissue1.13381554
53MP0001485_abnormal_pinna_reflex1.12137331
54MP0005623_abnormal_meninges_morphology1.10374972
55* MP0003634_abnormal_glial_cell1.08705253
56MP0001958_emphysema1.06026231
57MP0004145_abnormal_muscle_electrophysio1.04329966
58MP0000920_abnormal_myelination1.02233795
59MP0005171_absent_coat_pigmentation1.01761516
60MP0006276_abnormal_autonomic_nervous1.01656921
61MP0003632_abnormal_nervous_system1.01512669
62MP0001905_abnormal_dopamine_level1.01123029
63* MP0002152_abnormal_brain_morphology1.00987710
64MP0003122_maternal_imprinting0.99622233
65MP0004043_abnormal_pH_regulation0.97480834
66MP0001177_atelectasis0.95383560
67MP0003137_abnormal_impulse_conducting0.94416589
68MP0005670_abnormal_white_adipose0.93930373
69MP0000604_amyloidosis0.92633763
70MP0004085_abnormal_heartbeat0.91982983
71MP0001963_abnormal_hearing_physiology0.91165055
72MP0002229_neurodegeneration0.90348202
73MP0005551_abnormal_eye_electrophysiolog0.89422602
74MP0003283_abnormal_digestive_organ0.87368894
75MP0004484_altered_response_of0.86200460
76MP0002653_abnormal_ependyma_morphology0.85632510
77MP0008872_abnormal_physiological_respon0.84894305
78MP0004742_abnormal_vestibular_system0.83150375
79MP0001986_abnormal_taste_sensitivity0.82813559
80MP0002089_abnormal_postnatal_growth/wei0.82118317
81MP0002249_abnormal_larynx_morphology0.81507999
82MP0008874_decreased_physiological_sensi0.81409464
83MP0002638_abnormal_pupillary_reflex0.77458470
84MP0001299_abnormal_eye_distance/0.76589088
85MP0005388_respiratory_system_phenotype0.76152708
86MP0002133_abnormal_respiratory_system0.76152708
87MP0002069_abnormal_eating/drinking_beha0.75716656
88MP0002090_abnormal_vision0.75688590
89MP0005535_abnormal_body_temperature0.74794785
90MP0008961_abnormal_basal_metabolism0.72727061
91MP0002837_dystrophic_cardiac_calcinosis0.70684730
92MP0006138_congestive_heart_failure0.65859406
93MP0003878_abnormal_ear_physiology0.65151829
94MP0005377_hearing/vestibular/ear_phenot0.65151829
95MP0005595_abnormal_vascular_smooth0.64648657
96MP0004233_abnormal_muscle_weight0.63906086
97MP0001664_abnormal_digestion0.62976342
98MP0003136_yellow_coat_color0.62884536
99MP0005253_abnormal_eye_physiology0.62535507
100MP0003646_muscle_fatigue0.62046929
101MP0000579_abnormal_nail_morphology0.61720145
102MP0004130_abnormal_muscle_cell0.61582096
103MP0004147_increased_porphyrin_level0.61336100
104MP0002752_abnormal_somatic_nervous0.60563442
105MP0005620_abnormal_muscle_contractility0.60507833
106MP0000566_synostosis0.59924926
107MP0001943_abnormal_respiration0.58057094
108MP0000749_muscle_degeneration0.56348967
109MP0005166_decreased_susceptibility_to0.55046049
110MP0000747_muscle_weakness0.54991518
111MP0003868_abnormal_feces_composition0.54952147
112MP0002972_abnormal_cardiac_muscle0.54921833
113MP0010386_abnormal_urinary_bladder0.54596158
114MP0005409_darkened_coat_color0.53993323
115MP0004036_abnormal_muscle_relaxation0.53940840
116MP0000026_abnormal_inner_ear0.53661982

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.32525137
2Myokymia (HP:0002411)6.03119407
3Focal seizures (HP:0007359)5.29100221
4Hemiplegia (HP:0002301)4.72426093
5Visual hallucinations (HP:0002367)4.66846992
6Action tremor (HP:0002345)4.45334202
7Atonic seizures (HP:0010819)4.42541594
8Diplopia (HP:0000651)4.37106300
9Abnormality of binocular vision (HP:0011514)4.37106300
10Epileptic encephalopathy (HP:0200134)4.32539702
11Progressive cerebellar ataxia (HP:0002073)4.32488990
12Hemiparesis (HP:0001269)4.19164585
13Generalized tonic-clonic seizures (HP:0002069)4.04515298
14Febrile seizures (HP:0002373)4.01809974
15Absence seizures (HP:0002121)3.79433016
16Dysdiadochokinesis (HP:0002075)3.62481008
17Supranuclear gaze palsy (HP:0000605)3.61093631
18Aplasia involving bones of the extremities (HP:0009825)3.52826979
19Aplasia involving bones of the upper limbs (HP:0009823)3.52826979
20Aplasia of the phalanges of the hand (HP:0009802)3.52826979
21Dialeptic seizures (HP:0011146)3.43444719
22Megalencephaly (HP:0001355)3.37319814
23Postural instability (HP:0002172)3.26087115
24Depression (HP:0000716)3.23820992
25Abnormal eating behavior (HP:0100738)3.21020507
26Gaze-evoked nystagmus (HP:0000640)3.19534159
27Ankle clonus (HP:0011448)3.12299684
28Dysmetria (HP:0001310)3.07530720
29Truncal ataxia (HP:0002078)3.03779256
30Broad-based gait (HP:0002136)2.96574890
31Intention tremor (HP:0002080)2.95675099
32Split foot (HP:0001839)2.93768600
33Neurofibrillary tangles (HP:0002185)2.93365766
34Anxiety (HP:0000739)2.91281646
35Impaired vibration sensation in the lower limbs (HP:0002166)2.90031285
36Poor eye contact (HP:0000817)2.75288923
37Status epilepticus (HP:0002133)2.74265453
38Ventricular fibrillation (HP:0001663)2.72876370
39Scanning speech (HP:0002168)2.68027176
40Tetraplegia (HP:0002445)2.66512741
41Urinary bladder sphincter dysfunction (HP:0002839)2.62941139
42Impaired social interactions (HP:0000735)2.60891529
43Abnormal social behavior (HP:0012433)2.60891529
44Mutism (HP:0002300)2.54444405
45Impaired smooth pursuit (HP:0007772)2.50751089
46Papilledema (HP:0001085)2.50166419
47Cerebral inclusion bodies (HP:0100314)2.48076239
48Genetic anticipation (HP:0003743)2.46329273
49Hyporeflexia of lower limbs (HP:0002600)2.43363368
50Hyperventilation (HP:0002883)2.42993382
51Dysmetric saccades (HP:0000641)2.42890038
52Limb dystonia (HP:0002451)2.41477488
53Bradykinesia (HP:0002067)2.35567620
54Abnormality of ocular smooth pursuit (HP:0000617)2.31670711
55Torticollis (HP:0000473)2.29971380
56Annular pancreas (HP:0001734)2.28737861
57Abnormality of the lower motor neuron (HP:0002366)2.23864575
58Urinary urgency (HP:0000012)2.22865055
59Bundle branch block (HP:0011710)2.22459516
60Sleep apnea (HP:0010535)2.20170616
61Akinesia (HP:0002304)2.19482245
62Lower limb muscle weakness (HP:0007340)2.16160315
63Pheochromocytoma (HP:0002666)2.15624564
64Thickened helices (HP:0000391)2.13027681
65Amblyopia (HP:0000646)2.12935837
66Spastic gait (HP:0002064)2.12376492
67Stereotypic behavior (HP:0000733)2.09404129
68Insomnia (HP:0100785)2.08628928
69Heart block (HP:0012722)2.08470120
70Syncope (HP:0001279)2.07448006
71Focal dystonia (HP:0004373)2.07016562
72Abnormality of the corticospinal tract (HP:0002492)2.06163165
73Progressive inability to walk (HP:0002505)2.04918407
74Abnormality of saccadic eye movements (HP:0000570)2.02603966
75Sudden death (HP:0001699)2.01992161
76Impaired vibratory sensation (HP:0002495)2.01422090
77Confusion (HP:0001289)1.99165606
78Polyphagia (HP:0002591)1.98910596
79Incomplete penetrance (HP:0003829)1.98742790
80Neuronal loss in central nervous system (HP:0002529)1.98471174
81Muscle fiber splitting (HP:0003555)1.98209203
82Drooling (HP:0002307)1.98195780
83Excessive salivation (HP:0003781)1.98195780
84Foot dorsiflexor weakness (HP:0009027)1.95704411
85Cerebral hypomyelination (HP:0006808)1.94148409
86Postural tremor (HP:0002174)1.92280927
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91982837
88Degeneration of the lateral corticospinal tracts (HP:0002314)1.91982837
89Gait ataxia (HP:0002066)1.91037439
90Narrow nasal bridge (HP:0000446)1.91021627
91Abnormal atrioventricular conduction (HP:0005150)1.89712818
92Delusions (HP:0000746)1.88802484
93Abnormality of the foot musculature (HP:0001436)1.87534533
94Atrial fibrillation (HP:0005110)1.87032307
95Abnormal EKG (HP:0003115)1.86632620
96Rigidity (HP:0002063)1.86540912
97Neuroendocrine neoplasm (HP:0100634)1.85966495
98Neoplasm of the heart (HP:0100544)1.85081998
99Prolonged QT interval (HP:0001657)1.84906546
100Blue irides (HP:0000635)1.82229706
101Pointed chin (HP:0000307)1.82032274
102Psychosis (HP:0000709)1.81971371
103Abnormality of the periventricular white matter (HP:0002518)1.80537333
104Abnormality of the diencephalon (HP:0010662)1.80244959
105Alacrima (HP:0000522)1.79873074
106Spastic tetraparesis (HP:0001285)1.79774321
107Primary atrial arrhythmia (HP:0001692)1.79434335
108Fetal akinesia sequence (HP:0001989)1.79192531
109Craniofacial dystonia (HP:0012179)1.79058089
110Generalized myoclonic seizures (HP:0002123)1.78328153
111Spinal canal stenosis (HP:0003416)1.77801928
112Bronchomalacia (HP:0002780)1.77655538
113Turricephaly (HP:0000262)1.75982650
114Clonus (HP:0002169)1.74904015
115Peripheral hypomyelination (HP:0007182)1.74490502
116Atrioventricular block (HP:0001678)1.74288304
117Epileptiform EEG discharges (HP:0011182)1.73105973
118Apathy (HP:0000741)1.73011329
119Morphological abnormality of the inner ear (HP:0011390)1.72043567
120Agitation (HP:0000713)1.71711526
121Synostosis involving the elbow (HP:0003938)1.70946542
122Humeroradial synostosis (HP:0003041)1.70946542
123Exercise-induced myalgia (HP:0003738)1.70792454
124Clumsiness (HP:0002312)1.70036587
125Lower limb asymmetry (HP:0100559)1.69641617
126Increased circulating renin level (HP:0000848)1.69113373
127EEG with generalized epileptiform discharges (HP:0011198)1.68312536
128Obstructive sleep apnea (HP:0002870)1.67052266
129Rapidly progressive (HP:0003678)1.66477975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.14711850
2EPHA43.88557067
3MAP3K93.29215879
4NTRK22.83086580
5MAP3K42.81611245
6PRKD32.56585549
7MINK12.49137601
8MAP2K72.31267977
9MARK12.22230467
10DAPK22.17580053
11PAK62.17134616
12MAPK152.05664344
13LMTK22.00842464
14CAMKK11.96079311
15TNIK1.87626565
16MAP2K41.81335958
17NTRK11.77532190
18STK381.73114221
19PHKG21.71505282
20PHKG11.71505282
21KSR21.66239112
22CASK1.64061399
23RIPK41.49082633
24CDK51.47928723
25MAP3K121.46717951
26PRKCG1.30266623
27TYRO31.29815890
28PKN11.29095945
29GRK51.28499455
30PINK11.24109643
31SGK21.24003310
32SGK4941.23733731
33SGK2231.23733731
34CAMKK21.23001749
35FES1.21389662
36PLK21.21006453
37PRKCH1.19400945
38MAPK131.19114912
39CDK191.14081043
40SGK31.11615817
41PRPF4B1.09849668
42DAPK11.05841763
43RIPK11.05130990
44KSR11.04435461
45TNK21.00005507
46CAMK10.99107779
47MAP3K130.96024147
48CAMK2A0.95503324
49PNCK0.94873045
50WNK10.93031371
51UHMK10.91761507
52ARAF0.89060188
53SIK20.88782197
54STK110.84655800
55CAMK1G0.83526716
56CDC42BPA0.83015658
57PAK30.82414198
58ALK0.80563315
59MAP3K20.80082759
60CDK150.78688843
61MUSK0.77655926
62CDK180.76823151
63LATS20.75700959
64RET0.74745877
65SGK10.73548506
66CAMK2B0.73435772
67PTK2B0.73399247
68DMPK0.73011618
69NEK60.72413833
70CAMK2G0.71329343
71OXSR10.71281025
72CDK140.70991607
73DYRK1A0.69408995
74PDPK10.68652683
75MAPK120.68270525
76CDK11A0.66453902
77PDK10.66126962
78PRKCE0.64833937
79PDGFRA0.63916102
80TAOK10.63543688
81DDR20.62666164
82MARK20.60107933
83ERBB20.59418479
84ROCK20.59366032
85RPS6KA30.58166819
86CCNB10.56976590
87ROCK10.56052489
88PRKD10.55741202
89CAMK2D0.54151128
90TIE10.53877110
91FGFR20.52861779
92MAP3K70.52601988
93LIMK10.51743584
94MAPK70.51385190
95PDGFRB0.50503777
96MAP3K10.50482582
97CAMK40.49905475
98PRKG10.49660552
99PIK3CA0.49632844
100EPHA30.49293283
101FYN0.48356761
102MAPK100.48090688
103FGFR30.48059965
104FER0.47696014
105RAF10.47652882
106BMPR20.45869057
107PAK20.45772116
108MAPKAPK50.45698391
109NEK10.44449545
110MAPK40.44366178
111BMX0.42396688
112TSSK60.40502547
113TRIB30.40233766
114PDK30.39406033
115PDK40.39406033
116PRKCZ0.39088338
117PRKCA0.38490462
118CDK30.38393730

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.57258499
2Nitrogen metabolism_Homo sapiens_hsa009103.32646228
3GABAergic synapse_Homo sapiens_hsa047272.76979142
4Synaptic vesicle cycle_Homo sapiens_hsa047212.69989375
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.55910767
6Glutamatergic synapse_Homo sapiens_hsa047242.48006703
7Circadian entrainment_Homo sapiens_hsa047132.43233331
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40392359
9Olfactory transduction_Homo sapiens_hsa047402.31101671
10Morphine addiction_Homo sapiens_hsa050322.31013508
11Salivary secretion_Homo sapiens_hsa049702.27023499
12Long-term potentiation_Homo sapiens_hsa047202.23659828
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18482284
14Gastric acid secretion_Homo sapiens_hsa049712.10816809
15Insulin secretion_Homo sapiens_hsa049112.01016132
16Amphetamine addiction_Homo sapiens_hsa050312.00589941
17Dopaminergic synapse_Homo sapiens_hsa047281.69818888
18Taste transduction_Homo sapiens_hsa047421.65083375
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62544086
20Renin secretion_Homo sapiens_hsa049241.62135895
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60394827
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55102891
23Cholinergic synapse_Homo sapiens_hsa047251.53706289
24Calcium signaling pathway_Homo sapiens_hsa040201.51516433
25Long-term depression_Homo sapiens_hsa047301.51339606
26Oxytocin signaling pathway_Homo sapiens_hsa049211.41419506
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37488393
28Cocaine addiction_Homo sapiens_hsa050301.35420456
29cAMP signaling pathway_Homo sapiens_hsa040241.33533819
30Serotonergic synapse_Homo sapiens_hsa047261.27680338
31Fatty acid biosynthesis_Homo sapiens_hsa000611.26494057
32GnRH signaling pathway_Homo sapiens_hsa049121.24278679
33Gap junction_Homo sapiens_hsa045401.23007142
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09846472
35Dorso-ventral axis formation_Homo sapiens_hsa043201.09462078
36Pancreatic secretion_Homo sapiens_hsa049721.09261263
37Bile secretion_Homo sapiens_hsa049761.09037122
38Vitamin B6 metabolism_Homo sapiens_hsa007501.06475180
39Cardiac muscle contraction_Homo sapiens_hsa042601.04809193
40Histidine metabolism_Homo sapiens_hsa003401.04134218
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03487865
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02669441
43Estrogen signaling pathway_Homo sapiens_hsa049151.01953933
44Type II diabetes mellitus_Homo sapiens_hsa049300.98136261
45Melanogenesis_Homo sapiens_hsa049160.97744660
46Dilated cardiomyopathy_Homo sapiens_hsa054140.96878853
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96074719
48Thyroid hormone synthesis_Homo sapiens_hsa049180.94943358
49Collecting duct acid secretion_Homo sapiens_hsa049660.93702120
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92766580
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.91199713
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.89791221
53Glioma_Homo sapiens_hsa052140.86492366
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82382294
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80391252
56Axon guidance_Homo sapiens_hsa043600.79696340
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79058132
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77890185
59PPAR signaling pathway_Homo sapiens_hsa033200.74986844
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73767971
61ErbB signaling pathway_Homo sapiens_hsa040120.71096608
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69051489
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66361759
64Choline metabolism in cancer_Homo sapiens_hsa052310.64360103
65beta-Alanine metabolism_Homo sapiens_hsa004100.64026793
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63980459
67Arginine and proline metabolism_Homo sapiens_hsa003300.61912875
68MAPK signaling pathway_Homo sapiens_hsa040100.59162722
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58985128
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58896601
71Rap1 signaling pathway_Homo sapiens_hsa040150.58498630
72Mineral absorption_Homo sapiens_hsa049780.57243181
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57028286
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55065835
75Circadian rhythm_Homo sapiens_hsa047100.54926396
76Oocyte meiosis_Homo sapiens_hsa041140.54306486
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53966041
78Vibrio cholerae infection_Homo sapiens_hsa051100.52950208
79Glucagon signaling pathway_Homo sapiens_hsa049220.52665674
80Arginine biosynthesis_Homo sapiens_hsa002200.51468945
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51087934
82Ras signaling pathway_Homo sapiens_hsa040140.50389509
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49608556
84Protein digestion and absorption_Homo sapiens_hsa049740.47859516
85Inositol phosphate metabolism_Homo sapiens_hsa005620.47297307
86Type I diabetes mellitus_Homo sapiens_hsa049400.47227453
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.44960930
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.43212920
89Endocytosis_Homo sapiens_hsa041440.41524821
90Ovarian steroidogenesis_Homo sapiens_hsa049130.40820795
91Tight junction_Homo sapiens_hsa045300.38801890
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.38349496
93VEGF signaling pathway_Homo sapiens_hsa043700.37347672
94ECM-receptor interaction_Homo sapiens_hsa045120.33949559
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33905853
96Wnt signaling pathway_Homo sapiens_hsa043100.33585110
97Focal adhesion_Homo sapiens_hsa045100.32768656
98African trypanosomiasis_Homo sapiens_hsa051430.32452813
99ABC transporters_Homo sapiens_hsa020100.32199645
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31912384
101Prion diseases_Homo sapiens_hsa050200.31810892
102Insulin signaling pathway_Homo sapiens_hsa049100.30830396
103Phototransduction_Homo sapiens_hsa047440.29797777
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29453879
105Hippo signaling pathway_Homo sapiens_hsa043900.29240210
106AMPK signaling pathway_Homo sapiens_hsa041520.29060413
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28170856
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27785154
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.27538121
110mTOR signaling pathway_Homo sapiens_hsa041500.27462077
111Butanoate metabolism_Homo sapiens_hsa006500.26093063
112Renal cell carcinoma_Homo sapiens_hsa052110.25299827
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24140185
114Hedgehog signaling pathway_Homo sapiens_hsa043400.24056541

Most similar genes based on co-expression Upload to Enrichr

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