SPAST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.65281058
2layer formation in cerebral cortex (GO:0021819)4.92473014
3neural tube formation (GO:0001841)4.55981573
4nucleobase catabolic process (GO:0046113)4.41445283
5establishment of mitochondrion localization (GO:0051654)4.27069211
6mitotic sister chromatid cohesion (GO:0007064)4.20795150
7establishment of nucleus localization (GO:0040023)4.19150357
8central nervous system projection neuron axonogenesis (GO:0021952)4.03884401
9mitochondrion transport along microtubule (GO:0047497)4.02851437
10establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.02851437
11axonal fasciculation (GO:0007413)4.01073215
12cytoplasmic mRNA processing body assembly (GO:0033962)3.92033492
13regulation of RNA export from nucleus (GO:0046831)3.90323473
14cell migration in hindbrain (GO:0021535)3.89962683
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.77841235
16negative regulation of translation, ncRNA-mediated (GO:0040033)3.77841235
17regulation of translation, ncRNA-mediated (GO:0045974)3.77841235
18dendritic spine morphogenesis (GO:0060997)3.71261893
19neuron cell-cell adhesion (GO:0007158)3.62432336
20dendrite morphogenesis (GO:0048813)3.58491291
21neuron recognition (GO:0008038)3.56796444
22asymmetric protein localization (GO:0008105)3.53723535
23apical protein localization (GO:0045176)3.53229120
24postsynaptic membrane organization (GO:0001941)3.52212533
25pre-miRNA processing (GO:0031054)3.43427401
26microtubule anchoring (GO:0034453)3.38790608
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33688374
28cerebellar granule cell differentiation (GO:0021707)3.25832451
29monoubiquitinated protein deubiquitination (GO:0035520)3.25076237
30nucleus localization (GO:0051647)3.22285564
31olfactory bulb development (GO:0021772)3.21238420
32regulation of nucleobase-containing compound transport (GO:0032239)3.18944020
33synapse assembly (GO:0007416)3.16671923
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.16450753
35nerve growth factor signaling pathway (GO:0038180)3.15763067
36behavioral response to nicotine (GO:0035095)3.15429348
37cerebral cortex radially oriented cell migration (GO:0021799)3.15098627
38nuclear pore organization (GO:0006999)3.14740019
39establishment of protein localization to Golgi (GO:0072600)3.14080773
40protein localization to synapse (GO:0035418)3.13973570
41prenylation (GO:0097354)3.12733804
42protein prenylation (GO:0018342)3.12733804
43central nervous system neuron axonogenesis (GO:0021955)3.12296750
44startle response (GO:0001964)3.11729961
45protein targeting to Golgi (GO:0000042)3.09775563
46embryonic retina morphogenesis in camera-type eye (GO:0060059)3.07539483
47negative regulation of DNA recombination (GO:0045910)3.06757531
48clathrin coat assembly (GO:0048268)3.04045293
49nuclear pore complex assembly (GO:0051292)3.03992341
50axon extension (GO:0048675)3.00066713
51regulation of sister chromatid cohesion (GO:0007063)2.98985128
52limb bud formation (GO:0060174)2.98920994
53atrial cardiac muscle cell action potential (GO:0086014)2.98226457
54vocalization behavior (GO:0071625)2.96508932
55presynaptic membrane assembly (GO:0097105)2.95870598
56calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.94905595
57cerebellar Purkinje cell differentiation (GO:0021702)2.94703417
58DNA double-strand break processing (GO:0000729)2.93098617
59presynaptic membrane organization (GO:0097090)2.91482731
60regulation of DNA endoreduplication (GO:0032875)2.90080328
61regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.89046942
62neurotransmitter-gated ion channel clustering (GO:0072578)2.87716747
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.87623541
64central nervous system myelination (GO:0022010)2.87573342
65axon ensheathment in central nervous system (GO:0032291)2.87573342
66retrograde transport, vesicle recycling within Golgi (GO:0000301)2.87042707
67axonemal dynein complex assembly (GO:0070286)2.86160218
68somite development (GO:0061053)2.84601466
69ventricular system development (GO:0021591)2.83847287
70retinal ganglion cell axon guidance (GO:0031290)2.79452317
71forebrain neuron differentiation (GO:0021879)2.78652684
72cilium movement (GO:0003341)2.76769837
73interkinetic nuclear migration (GO:0022027)2.76370154
74piRNA metabolic process (GO:0034587)2.75328252
75neuronal stem cell maintenance (GO:0097150)2.73821129
76mechanosensory behavior (GO:0007638)2.72021571
77cilium or flagellum-dependent cell motility (GO:0001539)2.71562613
78nonmotile primary cilium assembly (GO:0035058)2.71277109
79regulation of dendritic spine morphogenesis (GO:0061001)2.70313973
80regulation of telomere maintenance (GO:0032204)2.69760160
81glutamate receptor signaling pathway (GO:0007215)2.65758919
82sympathetic nervous system development (GO:0048485)2.65518044
83regulation of synaptic vesicle exocytosis (GO:2000300)2.65249250
84regulation of short-term neuronal synaptic plasticity (GO:0048172)2.64835403
85histone H3-K9 methylation (GO:0051567)2.64760035
86lens morphogenesis in camera-type eye (GO:0002089)2.63736771
87camera-type eye morphogenesis (GO:0048593)2.61296837
88positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.60919051
89ectodermal placode formation (GO:0060788)2.60106077
90synaptic vesicle endocytosis (GO:0048488)2.59897772
91epithelial cell differentiation involved in kidney development (GO:0035850)2.58912206
92locomotory exploration behavior (GO:0035641)2.58885065
93auditory behavior (GO:0031223)2.58178851
94resolution of meiotic recombination intermediates (GO:0000712)2.56934214
95hippocampus development (GO:0021766)2.56673710
96cerebral cortex cell migration (GO:0021795)2.56367068
97neuron projection extension (GO:1990138)2.53903643
98organelle transport along microtubule (GO:0072384)2.52945599
99head development (GO:0060322)2.52780330
100regulation of DNA methylation (GO:0044030)2.52568216
101negative regulation of neurotransmitter transport (GO:0051589)2.51695556
102hippo signaling (GO:0035329)2.50563893
103adult walking behavior (GO:0007628)2.50124252
104synapse organization (GO:0050808)2.49310708
105synaptic transmission, glutamatergic (GO:0035249)2.48660866
106suckling behavior (GO:0001967)2.48586182
107positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.48294007
108phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.47883958
109negative regulation of axonogenesis (GO:0050771)2.47327992
110dorsal/ventral axis specification (GO:0009950)2.46970628
111dendrite development (GO:0016358)2.46958252
112ribonucleoprotein complex disassembly (GO:0032988)2.46434541
113negative regulation of axon extension (GO:0030517)2.45680987
114negative regulation of DNA-dependent DNA replication (GO:2000104)2.45335650
115negative regulation of dendrite development (GO:2000171)2.44604520
116negative regulation of fibroblast apoptotic process (GO:2000270)2.43663134
117positive regulation of dendritic spine morphogenesis (GO:0061003)2.43259505
118neuron migration (GO:0001764)2.43020070
119positive regulation of mRNA processing (GO:0050685)2.42116755
120negative regulation of histone methylation (GO:0031061)2.41636763
121mitotic chromosome condensation (GO:0007076)2.40592091
122stress granule assembly (GO:0034063)2.40510931
123negative regulation of oligodendrocyte differentiation (GO:0048715)2.40495774
124negative regulation of neurotransmitter secretion (GO:0046929)2.39070023
125positive regulation of mitotic sister chromatid separation (GO:1901970)2.39033747
126positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.39033747
127positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.39033747
128intraciliary transport (GO:0042073)2.38421420
129exploration behavior (GO:0035640)2.38365812
130peptidyl-lysine trimethylation (GO:0018023)2.37709252
131kidney morphogenesis (GO:0060993)2.36475819
132regulation of cAMP-dependent protein kinase activity (GO:2000479)2.36343919
133SMAD protein complex assembly (GO:0007183)2.36095465
134synaptic vesicle maturation (GO:0016188)2.36095245
135regulation of growth hormone secretion (GO:0060123)2.35353761
136gene silencing by RNA (GO:0031047)2.35323960
137negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.33827928
138embryonic epithelial tube formation (GO:0001838)2.33471473
139glycerophospholipid catabolic process (GO:0046475)2.32979767
140regulation of transforming growth factor beta2 production (GO:0032909)2.32020016
141negative regulation of organelle assembly (GO:1902116)2.31725035
142positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.31441600
143regulation of catenin import into nucleus (GO:0035412)2.30958278
144glucocorticoid receptor signaling pathway (GO:0042921)2.29132810
145regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.28935018
146mitotic cytokinesis (GO:0000281)2.28668435
147histone H2A monoubiquitination (GO:0035518)2.28460127
148cerebellum development (GO:0021549)2.27546101
149peptidyl-lysine dimethylation (GO:0018027)2.27348510
150glial cell proliferation (GO:0014009)2.26497712
151positive regulation of catenin import into nucleus (GO:0035413)2.26480348
152cytoskeleton-dependent cytokinesis (GO:0061640)2.25018022
153regulation of neuron migration (GO:2001222)2.24675246
154regulation of histone H3-K9 methylation (GO:0051570)2.24330693
155positive regulation of neurological system process (GO:0031646)2.23139393
156* neuron projection morphogenesis (GO:0048812)2.22580672
157cerebral cortex neuron differentiation (GO:0021895)2.21941377
158negative regulation of catenin import into nucleus (GO:0035414)2.21634282
159regulation of dendritic spine development (GO:0060998)2.21566054
160regulation of meiosis I (GO:0060631)2.21352525
161* axonogenesis (GO:0007409)2.21286953
162positive regulation of chromosome segregation (GO:0051984)2.21025243
163male meiosis (GO:0007140)2.20873231
164protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.20803048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.86218688
2EZH2_22144423_ChIP-Seq_EOC_Human3.79973076
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.49670703
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.14925641
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.11048095
6IGF1R_20145208_ChIP-Seq_DFB_Human2.31457067
7TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.28138470
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24669006
9GBX2_23144817_ChIP-Seq_PC3_Human2.20365833
10FUS_26573619_Chip-Seq_HEK293_Human2.07156953
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93469624
12AR_21572438_ChIP-Seq_LNCaP_Human1.93438658
13FLI1_27457419_Chip-Seq_LIVER_Mouse1.93252048
14VDR_22108803_ChIP-Seq_LS180_Human1.87812363
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85551716
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85431063
17SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.81239212
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79362078
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71181403
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69411543
21ZNF274_21170338_ChIP-Seq_K562_Hela1.67897323
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.67882595
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.67871162
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66583354
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64394166
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63766533
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63363137
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61675290
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61228915
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61082507
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61082507
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60702180
33TAF15_26573619_Chip-Seq_HEK293_Human1.60675737
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58927575
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55647600
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53399773
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51457475
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.48864296
39EWS_26573619_Chip-Seq_HEK293_Human1.46240191
40* STAT3_23295773_ChIP-Seq_U87_Human1.46235050
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.46090736
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44567668
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.43233422
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39724153
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39398427
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39391339
47* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.39084132
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38077510
49TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36534485
50RNF2_27304074_Chip-Seq_NSC_Mouse1.36079864
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.35382414
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34836871
53REST_21632747_ChIP-Seq_MESCs_Mouse1.34428245
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34324136
55SMAD4_21799915_ChIP-Seq_A2780_Human1.33911023
56YAP1_20516196_ChIP-Seq_MESCs_Mouse1.33249775
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.32403923
58CBP_20019798_ChIP-Seq_JUKART_Human1.32044834
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32044834
60FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31392646
61TP53_16413492_ChIP-PET_HCT116_Human1.31070667
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30494772
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.30471957
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30306953
65P300_19829295_ChIP-Seq_ESCs_Human1.29586928
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27712258
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.26678386
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26375313
69ER_23166858_ChIP-Seq_MCF-7_Human1.26201042
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25017995
71P53_22387025_ChIP-Seq_ESCs_Mouse1.24954206
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.23906468
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23502199
74RUNX2_22187159_ChIP-Seq_PCA_Human1.23096834
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22497433
76TCF4_18268006_ChIP-ChIP_LS174T_Human1.21475587
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21457167
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.21362898
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.21098041
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.20906156
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.19262861
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.18936607
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18936542
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18724274
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18616273
86EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18542331
87RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18542331
88DROSHA_22980978_ChIP-Seq_HELA_Human1.18490749
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18161112
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17820394
91RARB_27405468_Chip-Seq_BRAIN_Mouse1.17586692
92TCF4_23295773_ChIP-Seq_U87_Human1.16937414
93EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16881821
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16845890
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.16792004
96JUN_21703547_ChIP-Seq_K562_Human1.15205520
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15065106
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15003894
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14946737
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14666306
101SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13506642
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.13455832
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.13444268
104* AR_19668381_ChIP-Seq_PC3_Human1.12939757
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12324860
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12082901
107GATA1_26923725_Chip-Seq_HPCs_Mouse1.11871195
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11719235
109EZH2_27294783_Chip-Seq_ESCs_Mouse1.11355197
110ELK1_19687146_ChIP-ChIP_HELA_Human1.10872992
111TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10741545
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.09990919
113TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09778898
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08888713
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08787813
116P300_18555785_Chip-Seq_ESCs_Mouse1.08497062
117EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07713271
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07578763
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07318389
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06393981
121MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05505374
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.05118863
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04472186
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04451949
125SOX9_26525672_Chip-Seq_HEART_Mouse1.04035309
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03482337
127STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03132248
128SOX2_16153702_ChIP-ChIP_HESCs_Human1.02432977
129SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02057272
130WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01828216
131TBL1_22424771_ChIP-Seq_293T_Human1.00538055
132TCF4_22108803_ChIP-Seq_LS180_Human1.00288280
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99642779
134ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99568328
135AR_25329375_ChIP-Seq_VCAP_Human0.99103538
136BCAT_22108803_ChIP-Seq_LS180_Human0.99049822
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.98715441
138SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98613191
139E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97749816
140TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97050833

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000778_abnormal_nervous_system3.25984657
2MP0004859_abnormal_synaptic_plasticity3.13881481
3MP0004270_analgesia3.04255713
4MP0000537_abnormal_urethra_morphology2.63628131
5MP0008057_abnormal_DNA_replication2.48865229
6MP0001188_hyperpigmentation2.40233272
7MP0005187_abnormal_penis_morphology2.39366327
8MP0003787_abnormal_imprinting2.29959883
9MP0003890_abnormal_embryonic-extraembry2.25991574
10MP0000569_abnormal_digit_pigmentation2.22252285
11MP0001529_abnormal_vocalization2.16619421
12MP0004885_abnormal_endolymph2.03575611
13MP0002822_catalepsy2.02248304
14MP0010234_abnormal_vibrissa_follicle2.02012939
15MP0003121_genomic_imprinting2.01377116
16MP0006276_abnormal_autonomic_nervous1.96001979
17MP0002009_preneoplasia1.95881107
18MP0003635_abnormal_synaptic_transmissio1.93390856
19MP0003861_abnormal_nervous_system1.87291897
20MP0003937_abnormal_limbs/digits/tail_de1.82261010
21MP0003880_abnormal_central_pattern1.78451884
22MP0002735_abnormal_chemical_nociception1.78351581
23MP0008877_abnormal_DNA_methylation1.75090465
24MP0009046_muscle_twitch1.73058056
25MP0002653_abnormal_ependyma_morphology1.70837493
26MP0010678_abnormal_skin_adnexa1.69352975
27MP0002184_abnormal_innervation1.63333362
28MP0003567_abnormal_fetal_cardiomyocyte1.61182733
29MP0002063_abnormal_learning/memory/cond1.59002472
30MP0004142_abnormal_muscle_tone1.58025779
31MP0002736_abnormal_nociception_after1.57037989
32MP0002751_abnormal_autonomic_nervous1.56155992
33MP0000955_abnormal_spinal_cord1.55998484
34MP0002152_abnormal_brain_morphology1.54564769
35MP0002102_abnormal_ear_morphology1.53435383
36MP0001299_abnormal_eye_distance/1.51290187
37MP0009780_abnormal_chondrocyte_physiolo1.48883991
38MP0005248_abnormal_Harderian_gland1.48173414
39MP0005645_abnormal_hypothalamus_physiol1.47480963
40MP0002067_abnormal_sensory_capabilities1.45504751
41MP0002272_abnormal_nervous_system1.45095141
42MP0001968_abnormal_touch/_nociception1.43991929
43MP0003755_abnormal_palate_morphology1.42366534
44MP0001486_abnormal_startle_reflex1.39431811
45MP0002734_abnormal_mechanical_nocicepti1.39397336
46MP0005423_abnormal_somatic_nervous1.37864154
47MP0003329_amyloid_beta_deposits1.35968967
48* MP0002882_abnormal_neuron_morphology1.34187390
49MP0005253_abnormal_eye_physiology1.33184901
50MP0002064_seizures1.31175886
51* MP0004811_abnormal_neuron_physiology1.30419889
52MP0003698_abnormal_male_reproductive1.28192701
53MP0009053_abnormal_anal_canal1.27777026
54MP0002084_abnormal_developmental_patter1.26617144
55MP0001485_abnormal_pinna_reflex1.24717991
56MP0009672_abnormal_birth_weight1.23307403
57MP0002638_abnormal_pupillary_reflex1.22059012
58MP0008995_early_reproductive_senescence1.21280770
59MP0008789_abnormal_olfactory_epithelium1.20257536
60MP0002909_abnormal_adrenal_gland1.19918425
61MP0001984_abnormal_olfaction1.19865005
62MP0010386_abnormal_urinary_bladder1.17704577
63MP0003935_abnormal_craniofacial_develop1.16445701
64MP0004147_increased_porphyrin_level1.16196672
65MP0005076_abnormal_cell_differentiation1.15100462
66MP0005623_abnormal_meninges_morphology1.14768940
67MP0010094_abnormal_chromosome_stability1.14258114
68MP0001929_abnormal_gametogenesis1.14040555
69MP0003938_abnormal_ear_development1.13145104
70MP0009250_abnormal_appendicular_skeleto1.13121622
71MP0008058_abnormal_DNA_repair1.12337540
72MP0000462_abnormal_digestive_system1.11166063
73MP0000631_abnormal_neuroendocrine_gland1.10722637
74MP0002085_abnormal_embryonic_tissue1.09755105
75MP0003123_paternal_imprinting1.09678416
76MP0000920_abnormal_myelination1.08651309
77MP0001970_abnormal_pain_threshold1.08542656
78MP0009703_decreased_birth_body1.08351632
79MP0005386_behavior/neurological_phenoty1.08108862
80MP0004924_abnormal_behavior1.08108862
81MP0000383_abnormal_hair_follicle1.07734011
82MP0002557_abnormal_social/conspecific_i1.07211437
83MP0003119_abnormal_digestive_system1.04598620
84MP0003385_abnormal_body_wall1.04464794
85MP0001730_embryonic_growth_arrest1.04426639
86MP0002081_perinatal_lethality1.03876705
87MP0003942_abnormal_urinary_system1.03857448
88MP0002210_abnormal_sex_determination1.02018893
89MP0001340_abnormal_eyelid_morphology1.01316337
90MP0003122_maternal_imprinting1.01269974
91MP0000647_abnormal_sebaceous_gland1.00581504
92MP0001286_abnormal_eye_development1.00145643
93MP0001293_anophthalmia0.99545889
94MP0005647_abnormal_sex_gland0.99484659
95MP0003221_abnormal_cardiomyocyte_apopto0.98918121
96MP0010352_gastrointestinal_tract_polyps0.98554608
97MP0003632_abnormal_nervous_system0.98348169
98MP0002752_abnormal_somatic_nervous0.97736790
99MP0005551_abnormal_eye_electrophysiolog0.97233439
100MP0000428_abnormal_craniofacial_morphol0.97102845
101MP0005410_abnormal_fertilization0.96972776
102MP0000427_abnormal_hair_cycle0.96795934
103MP0004133_heterotaxia0.96791987
104MP0000653_abnormal_sex_gland0.96716762
105MP0002733_abnormal_thermal_nociception0.96687490
106MP0000733_abnormal_muscle_development0.96576302
107MP0002233_abnormal_nose_morphology0.95910674
108MP0000579_abnormal_nail_morphology0.95179454
109MP0002572_abnormal_emotion/affect_behav0.94601597
110MP0003315_abnormal_perineum_morphology0.92703013
111MP0004233_abnormal_muscle_weight0.92591143
112MP0002116_abnormal_craniofacial_bone0.92399282
113MP0001177_atelectasis0.91196705
114MP0003705_abnormal_hypodermis_morpholog0.90612179
115MP0009697_abnormal_copulation0.90600140
116MP0004742_abnormal_vestibular_system0.90082716
117MP0004134_abnormal_chest_morphology0.90079823
118* MP0002161_abnormal_fertility/fecundity0.89668184
119MP0005391_vision/eye_phenotype0.89667910
120MP0001145_abnormal_male_reproductive0.89415582
121MP0005195_abnormal_posterior_eye0.88310442
122MP0001348_abnormal_lacrimal_gland0.87991100
123MP0002092_abnormal_eye_morphology0.87844463
124MP0003634_abnormal_glial_cell0.87315008
125MP0003115_abnormal_respiratory_system0.86933757
126MP0004197_abnormal_fetal_growth/weight/0.86473182
127MP0001849_ear_inflammation0.86389483
128MP0005394_taste/olfaction_phenotype0.85995402
129MP0005499_abnormal_olfactory_system0.85995402
130MP0006072_abnormal_retinal_apoptosis0.84599621
131MP0000465_gastrointestinal_hemorrhage0.84103121
132MP0006054_spinal_hemorrhage0.83551813
133* MP0002066_abnormal_motor_capabilities/c0.83546653
134MP0009745_abnormal_behavioral_response0.83359726
135MP0003633_abnormal_nervous_system0.81554859
136MP0002229_neurodegeneration0.78121767
137MP0000049_abnormal_middle_ear0.75578203
138MP0003631_nervous_system_phenotype0.74791785
139MP0006292_abnormal_olfactory_placode0.74784509
140MP0003283_abnormal_digestive_organ0.73486892
141MP0001440_abnormal_grooming_behavior0.71156979

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.08572443
2Amyotrophic lateral sclerosis (HP:0007354)4.03426990
3Papillary thyroid carcinoma (HP:0002895)3.61721769
4Male infertility (HP:0003251)3.49092654
5* Abnormality of the corticospinal tract (HP:0002492)3.43616208
6Abnormal respiratory motile cilium physiology (HP:0012261)3.24575933
7Short 4th metacarpal (HP:0010044)3.23991841
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.23991841
9* Termporal pattern (HP:0011008)3.04497974
10* Insidious onset (HP:0003587)3.04497974
11Protruding tongue (HP:0010808)2.83681650
12Volvulus (HP:0002580)2.80628429
13Abnormality of the astrocytes (HP:0100707)2.77302131
14Astrocytoma (HP:0009592)2.77302131
15Drooling (HP:0002307)2.76244731
16Excessive salivation (HP:0003781)2.76244731
17Abnormality of the lower motor neuron (HP:0002366)2.74429573
18Hyperventilation (HP:0002883)2.68751064
19Cortical dysplasia (HP:0002539)2.67009903
20Abnormality of the 4th metacarpal (HP:0010012)2.59657971
21Febrile seizures (HP:0002373)2.58113337
22Rhinitis (HP:0012384)2.57224344
23Chronic hepatic failure (HP:0100626)2.54673306
24Progressive cerebellar ataxia (HP:0002073)2.51540270
25Abnormal ciliary motility (HP:0012262)2.47033814
26Heterotopia (HP:0002282)2.46233852
27* Degeneration of the lateral corticospinal tracts (HP:0002314)2.46226134
28* Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.46226134
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.46059521
30Absent/shortened dynein arms (HP:0200106)2.46059521
31Polyphagia (HP:0002591)2.45966917
32Medulloblastoma (HP:0002885)2.44462069
33Colon cancer (HP:0003003)2.42270868
34Cerebral inclusion bodies (HP:0100314)2.39522462
35Neurofibrillary tangles (HP:0002185)2.39255136
36Ankle clonus (HP:0011448)2.35614015
37Abnormality of the labia minora (HP:0012880)2.35175301
38* Inappropriate behavior (HP:0000719)2.33543347
39Focal motor seizures (HP:0011153)2.29896885
40Curly hair (HP:0002212)2.29063111
41Sacral dimple (HP:0000960)2.27402996
42Aqueductal stenosis (HP:0002410)2.26850930
43Macroorchidism (HP:0000053)2.25987810
44* Spastic gait (HP:0002064)2.24866575
45* Impaired vibration sensation in the lower limbs (HP:0002166)2.23723888
46Overriding aorta (HP:0002623)2.19127874
47True hermaphroditism (HP:0010459)2.19111484
48Hepatoblastoma (HP:0002884)2.18523830
49Intestinal atresia (HP:0011100)2.17888214
50Focal seizures (HP:0007359)2.16366216
51Shoulder girdle muscle weakness (HP:0003547)2.15316083
52* Morphological abnormality of the pyramidal tract (HP:0002062)2.14861214
53Exotropia (HP:0000577)2.13938203
54Renovascular hypertension (HP:0100817)2.11856246
55Facial hemangioma (HP:0000329)2.11781470
56Gonadotropin excess (HP:0000837)2.10711258
57Akinesia (HP:0002304)2.10112940
58Gaze-evoked nystagmus (HP:0000640)2.09446173
59Buphthalmos (HP:0000557)2.09415325
60Abnormal lung lobation (HP:0002101)2.08505426
61Limb dystonia (HP:0002451)2.08497022
62Glioma (HP:0009733)2.07634254
63* Urinary urgency (HP:0000012)2.06465001
64Papilledema (HP:0001085)2.05991784
65Increased nuchal translucency (HP:0010880)2.03626542
66Neoplasm of the oral cavity (HP:0100649)2.03626292
67Thyroid carcinoma (HP:0002890)2.03360792
68Pachygyria (HP:0001302)2.03341829
69Cystic hygroma (HP:0000476)2.02129640
70Mutism (HP:0002300)2.01033243
71Ependymoma (HP:0002888)2.00169945
72Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.00164532
73Abnormal respiratory epithelium morphology (HP:0012253)1.99951656
74Abnormal respiratory motile cilium morphology (HP:0005938)1.99951656
75Aplasia/Hypoplasia of the tibia (HP:0005772)1.99949190
76Truncal obesity (HP:0001956)1.99712847
77Pheochromocytoma (HP:0002666)1.98605654
78Failure to thrive in infancy (HP:0001531)1.97914985
79Atonic seizures (HP:0010819)1.97363236
80Progressive inability to walk (HP:0002505)1.96597571
81* Urinary bladder sphincter dysfunction (HP:0002839)1.96081542
82* Agitation (HP:0000713)1.96049885
83Scrotal hypoplasia (HP:0000046)1.94778383
84Subacute progressive viral hepatitis (HP:0006572)1.94733036
85Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94656921
86Hypoplasia of the brainstem (HP:0002365)1.94656921
87Nephroblastoma (Wilms tumor) (HP:0002667)1.93067308
88Action tremor (HP:0002345)1.92838542
89Coronal craniosynostosis (HP:0004440)1.92095520
90Intellectual disability, moderate (HP:0002342)1.91930442
91Infertility (HP:0000789)1.91674389
92Megalencephaly (HP:0001355)1.91048075
93Abnormality of the diencephalon (HP:0010662)1.90423982
94Chronic bronchitis (HP:0004469)1.89718879
95Lissencephaly (HP:0001339)1.88630186
96Cupped ear (HP:0000378)1.88601623
97Leiomyosarcoma (HP:0100243)1.88289486
98Uterine leiomyosarcoma (HP:0002891)1.88289486
99Gastrointestinal carcinoma (HP:0002672)1.87758509
100Malignant gastrointestinal tract tumors (HP:0006749)1.87758509
101Shallow orbits (HP:0000586)1.86735202
102Specific learning disability (HP:0001328)1.86385072
103Large earlobe (HP:0009748)1.85847238
104Hip dysplasia (HP:0001385)1.85827335
105Midline defect of the nose (HP:0004122)1.85482396
106Hyperacusis (HP:0010780)1.84862035
107Dyskinesia (HP:0100660)1.84741740
108Microglossia (HP:0000171)1.84479201
109Biliary tract neoplasm (HP:0100574)1.84049890
110* Paraplegia (HP:0010550)1.83535911
111Supranuclear gaze palsy (HP:0000605)1.83364951
112* Disinhibition (HP:0000734)1.81685864
113Short tibia (HP:0005736)1.81446293
114Genital tract atresia (HP:0001827)1.80764116
115Long clavicles (HP:0000890)1.80759563
116Widely spaced teeth (HP:0000687)1.80530224
117Elfin facies (HP:0004428)1.80282472
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.79951113
119Embryonal renal neoplasm (HP:0011794)1.78803559
120Abnormality of the hip-girdle musculature (HP:0001445)1.78600152
121Abnormality of the musculature of the pelvis (HP:0001469)1.78600152
122Transitional cell carcinoma of the bladder (HP:0006740)1.78531243
123Pancreatic fibrosis (HP:0100732)1.77629724
124Arnold-Chiari malformation (HP:0002308)1.77391257
125Oligodactyly (hands) (HP:0001180)1.76741334
126Abnormal hair whorl (HP:0010721)1.75874206
127Thyroid-stimulating hormone excess (HP:0002925)1.75196903
128Ankyloglossia (HP:0010296)1.74913681
129Pancreatic cysts (HP:0001737)1.74525451
130Nephronophthisis (HP:0000090)1.73429351
131Vaginal atresia (HP:0000148)1.72803046
132Oligodactyly (HP:0012165)1.72765819
133High anterior hairline (HP:0009890)1.72586631
134Abnormality of salivation (HP:0100755)1.72513367
135Epileptic encephalopathy (HP:0200134)1.71436829
136Menstrual irregularities (HP:0000858)1.70679186
137Rimmed vacuoles (HP:0003805)1.70610023
138Obsessive-compulsive behavior (HP:0000722)1.70265427
139Abnormality of the pubic bones (HP:0003172)1.70242003
140Narrow forehead (HP:0000341)1.69827810
141Medial flaring of the eyebrow (HP:0010747)1.69517120
142Omphalocele (HP:0001539)1.69140644
143Renal cortical cysts (HP:0000803)1.69096083
144Abnormal auditory evoked potentials (HP:0006958)1.68632009
145Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68273280
146Absent speech (HP:0001344)1.67625752
147Cutaneous finger syndactyly (HP:0010554)1.67499941
148Abnormality of chromosome segregation (HP:0002916)1.65329092
149Anteriorly placed anus (HP:0001545)1.64720768
150Gait imbalance (HP:0002141)1.64076744
151Occipital encephalocele (HP:0002085)1.62589640
152Insomnia (HP:0100785)1.61165598
153Sporadic (HP:0003745)1.59990233
154Supernumerary spleens (HP:0009799)1.59353320
155Broad-based gait (HP:0002136)1.59342021
156Renal duplication (HP:0000075)1.59228929
157Fibrous tissue neoplasm (HP:0012316)1.59197197
158Neoplasm of striated muscle (HP:0009728)1.58744854
159Bladder carcinoma (HP:0002862)1.57879291
160Bladder neoplasm (HP:0009725)1.57879291

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.71525419
2CASK4.29410253
3WNK32.96717600
4TNIK2.62105856
5LATS12.53308549
6DYRK22.38319483
7MAP3K42.29381204
8MAP3K92.14693562
9FGFR22.11468949
10LATS22.09248762
11ERBB32.04344353
12TRIM282.03820532
13MAPK131.99758638
14PAK61.99608467
15PNCK1.99490731
16CDC71.97809060
17CSNK1A1L1.92962311
18CSNK1G21.85944302
19KSR11.82371940
20NTRK21.78872535
21EPHA31.75656817
22CSNK1G31.73656968
23MAP3K61.62435471
24TYRO31.60833105
25CSNK1G11.56004174
26ICK1.54923661
27EEF2K1.51389928
28PHKG11.48790004
29PHKG21.48790004
30BCR1.46652289
31RPS6KA41.46126317
32TSSK61.43587122
33CAMK1G1.41177127
34NUAK11.40203422
35ERBB41.38052150
36STK391.37109457
37BMPR1B1.27818703
38MAP2K41.26364072
39MINK11.23594237
40YES11.20046832
41MAP2K71.20039581
42MAP4K21.18263082
43PRKD31.17223729
44SGK21.17018134
45PKN11.16317160
46PKN21.12636296
47SCYL21.11067185
48RET1.09858183
49EIF2AK31.08717499
50KSR21.07620676
51PINK11.06165665
52EPHA40.99306323
53CHEK20.94911328
54STK38L0.93218469
55PAK30.92877384
56MKNK10.91831021
57CSNK1D0.91136106
58MAP3K100.91097186
59LIMK10.89819407
60CAMKK20.88355237
61NTRK30.87149247
62PLK40.86980226
63DYRK1A0.83977923
64ZAK0.83345579
65CDK120.81288015
66UHMK10.80766779
67MELK0.78170973
68STK30.77959645
69STK110.76533942
70DYRK30.74835679
71CAMK1D0.74495554
72PRKCG0.74413108
73CDK50.72297907
74ALK0.71810750
75PLK20.70045763
76CDK140.67319909
77ACVR1B0.64891389
78MKNK20.64002798
79NEK20.63769607
80CSNK1E0.63483556
81CDK190.62413654
82CDK150.61683833
83MARK20.59993191
84CDK180.58884632
85MTOR0.58382544
86RAF10.58371143
87SGK10.57857500
88CAMK40.56633446
89PDK40.56523746
90PDK30.56523746
91SIK30.55804251
92PLK30.55792828
93PRKCE0.53946466
94SRPK10.53225116
95FGFR10.52974622
96DMPK0.52538484
97ERBB20.52249022
98CDK60.51887668
99* CDK10.51466860
100FRK0.51230198
101DAPK20.49676128
102SGK30.49202655
103ATM0.48851008
104CDK11A0.48567873
105BRD40.48243647
106OXSR10.48148697
107WNK10.47804430
108CDK30.47702641
109PDGFRA0.47660971
110CAMK2A0.46872270
111TAOK30.46381050
112MAPK100.46335693
113PRKCZ0.46272584
114MAP3K20.45409982
115MAPK90.45365821
116CDK20.44958034
117MAPKAPK50.44791843
118SGK4940.43770711
119SGK2230.43770711
120INSRR0.43649695
121DYRK1B0.43362670
122GSK3B0.43253178
123FGFR30.43042439
124CHEK10.42872266
125FGR0.41226531
126TAOK10.40943695
127RPS6KA50.39713248
128PRKAA10.39580916
129PRKDC0.39350849
130SIK20.39337805
131RPS6KB10.39272626
132RPS6KA20.38735122
133PLK10.37433539
134ADRBK20.36627434
135WNK40.34707233
136PRKACB0.33389933
137TEC0.30989237
138PIK3CA0.30941430

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043602.45682418
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37917179
3Colorectal cancer_Homo sapiens_hsa052102.08185011
4Basal transcription factors_Homo sapiens_hsa030222.01754732
5Dorso-ventral axis formation_Homo sapiens_hsa043201.86213615
6Oocyte meiosis_Homo sapiens_hsa041141.73446855
7Renal cell carcinoma_Homo sapiens_hsa052111.68733893
8Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.65787111
9Hippo signaling pathway_Homo sapiens_hsa043901.65031755
10Basal cell carcinoma_Homo sapiens_hsa052171.64411327
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62180605
12Endometrial cancer_Homo sapiens_hsa052131.59479201
13Taste transduction_Homo sapiens_hsa047421.59172740
14Nitrogen metabolism_Homo sapiens_hsa009101.54982836
15Olfactory transduction_Homo sapiens_hsa047401.53422144
16ErbB signaling pathway_Homo sapiens_hsa040121.52807853
17Long-term potentiation_Homo sapiens_hsa047201.51663406
18Dopaminergic synapse_Homo sapiens_hsa047281.51499785
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49863617
20Wnt signaling pathway_Homo sapiens_hsa043101.48691110
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47254749
22Glutamatergic synapse_Homo sapiens_hsa047241.44912560
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.41258048
24RNA degradation_Homo sapiens_hsa030181.37264993
25Ovarian steroidogenesis_Homo sapiens_hsa049131.34958238
26mRNA surveillance pathway_Homo sapiens_hsa030151.34763105
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34506190
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33930212
29Glioma_Homo sapiens_hsa052141.31893328
30MicroRNAs in cancer_Homo sapiens_hsa052061.30332284
31Long-term depression_Homo sapiens_hsa047301.30304815
32Pancreatic cancer_Homo sapiens_hsa052121.28781270
33Cell cycle_Homo sapiens_hsa041101.28765045
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27765613
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.27663840
36Hedgehog signaling pathway_Homo sapiens_hsa043401.24728721
37Circadian entrainment_Homo sapiens_hsa047131.23154869
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21827325
39mTOR signaling pathway_Homo sapiens_hsa041501.21163457
40Gap junction_Homo sapiens_hsa045401.19969702
41Phototransduction_Homo sapiens_hsa047441.18968208
42Nicotine addiction_Homo sapiens_hsa050331.17909268
43Alcoholism_Homo sapiens_hsa050341.16720666
44Estrogen signaling pathway_Homo sapiens_hsa049151.16676213
45GnRH signaling pathway_Homo sapiens_hsa049121.16505480
46Tight junction_Homo sapiens_hsa045301.14938710
47Amphetamine addiction_Homo sapiens_hsa050311.14184206
48Protein export_Homo sapiens_hsa030601.12937841
49Melanogenesis_Homo sapiens_hsa049161.11377647
50Cholinergic synapse_Homo sapiens_hsa047251.09993041
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09068632
52Cocaine addiction_Homo sapiens_hsa050301.04081373
53TGF-beta signaling pathway_Homo sapiens_hsa043501.03281488
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03172685
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02938094
56Oxytocin signaling pathway_Homo sapiens_hsa049211.00478164
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00308707
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99167194
59Non-small cell lung cancer_Homo sapiens_hsa052230.98667637
60Steroid biosynthesis_Homo sapiens_hsa001000.97827838
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97119259
62GABAergic synapse_Homo sapiens_hsa047270.96456420
63Non-homologous end-joining_Homo sapiens_hsa034500.96307428
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95914051
65Renin secretion_Homo sapiens_hsa049240.95492902
66Adherens junction_Homo sapiens_hsa045200.93068421
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91907046
68Choline metabolism in cancer_Homo sapiens_hsa052310.91224551
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90942368
70Prostate cancer_Homo sapiens_hsa052150.89925232
71Ether lipid metabolism_Homo sapiens_hsa005650.88823652
72Circadian rhythm_Homo sapiens_hsa047100.88754867
73Chronic myeloid leukemia_Homo sapiens_hsa052200.88702725
74MAPK signaling pathway_Homo sapiens_hsa040100.87852233
75Butanoate metabolism_Homo sapiens_hsa006500.87500564
76Type II diabetes mellitus_Homo sapiens_hsa049300.87307431
77Fanconi anemia pathway_Homo sapiens_hsa034600.86813740
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85818179
79Morphine addiction_Homo sapiens_hsa050320.84620033
80Synaptic vesicle cycle_Homo sapiens_hsa047210.83300991
81VEGF signaling pathway_Homo sapiens_hsa043700.82814890
82Fatty acid biosynthesis_Homo sapiens_hsa000610.82594327
83Ras signaling pathway_Homo sapiens_hsa040140.82193444
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82060591
85Lysine degradation_Homo sapiens_hsa003100.82024125
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81624058
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80468749
88cAMP signaling pathway_Homo sapiens_hsa040240.80070816
89AMPK signaling pathway_Homo sapiens_hsa041520.77980628
90Selenocompound metabolism_Homo sapiens_hsa004500.77409782
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77376426
92Propanoate metabolism_Homo sapiens_hsa006400.75633635
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74749008
94Systemic lupus erythematosus_Homo sapiens_hsa053220.73607025
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.72388139
96Prolactin signaling pathway_Homo sapiens_hsa049170.72247689
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71463177
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70618116
99Serotonergic synapse_Homo sapiens_hsa047260.69447001
100Inositol phosphate metabolism_Homo sapiens_hsa005620.69157361
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68581105
102Vitamin B6 metabolism_Homo sapiens_hsa007500.68540216
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68069248
104Viral myocarditis_Homo sapiens_hsa054160.67151658
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.65294771
106Gastric acid secretion_Homo sapiens_hsa049710.64648310
107Glucagon signaling pathway_Homo sapiens_hsa049220.64330465
108Endocytosis_Homo sapiens_hsa041440.63860617
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.63389025
110FoxO signaling pathway_Homo sapiens_hsa040680.62551123
111Spliceosome_Homo sapiens_hsa030400.62327565
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62084540
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60291039
114Rap1 signaling pathway_Homo sapiens_hsa040150.59548847
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59356915
116Insulin signaling pathway_Homo sapiens_hsa049100.59085091
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58871410
118Melanoma_Homo sapiens_hsa052180.58000571
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57240701
120Pathways in cancer_Homo sapiens_hsa052000.57153172
121Arginine biosynthesis_Homo sapiens_hsa002200.56429236
122Regulation of autophagy_Homo sapiens_hsa041400.56165676
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55252967
124RNA transport_Homo sapiens_hsa030130.54553796
125Proteoglycans in cancer_Homo sapiens_hsa052050.54497571
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52842928
127Insulin secretion_Homo sapiens_hsa049110.50850144
128T cell receptor signaling pathway_Homo sapiens_hsa046600.50466001
129Salivary secretion_Homo sapiens_hsa049700.49316274
130Platelet activation_Homo sapiens_hsa046110.49119166
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47492713

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