SPATA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.84620828
2sperm-egg recognition (GO:0035036)9.81340687
3plasma membrane fusion (GO:0045026)9.79824207
4axonemal dynein complex assembly (GO:0070286)9.59812570
5reproduction (GO:0000003)9.13474989
6motile cilium assembly (GO:0044458)8.89380261
7cell-cell recognition (GO:0009988)8.80057314
8epithelial cilium movement (GO:0003351)8.73811640
9acrosome reaction (GO:0007340)8.65166447
10binding of sperm to zona pellucida (GO:0007339)8.14842682
11piRNA metabolic process (GO:0034587)8.12634989
12male meiosis (GO:0007140)7.51831284
13cilium movement (GO:0003341)7.42313344
14spermatid development (GO:0007286)7.31506718
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.20350948
16single fertilization (GO:0007338)7.08349498
17regulation of cilium movement (GO:0003352)6.50104505
18sperm capacitation (GO:0048240)6.00616027
19synaptonemal complex organization (GO:0070193)5.90238314
20DNA methylation involved in gamete generation (GO:0043046)5.81349893
21response to pheromone (GO:0019236)5.74786951
22synaptonemal complex assembly (GO:0007130)5.67541946
23fertilization (GO:0009566)5.57307742
24microtubule depolymerization (GO:0007019)4.98726164
25spermatogenesis (GO:0007283)4.83889548
26male gamete generation (GO:0048232)4.82094939
27male meiosis I (GO:0007141)4.64892624
28protein K11-linked deubiquitination (GO:0035871)4.58416882
29chromosome organization involved in meiosis (GO:0070192)4.54397378
30gamete generation (GO:0007276)4.44168396
31centriole assembly (GO:0098534)4.39496531
32spermatid nucleus differentiation (GO:0007289)4.38901483
33cellular process involved in reproduction in multicellular organism (GO:0022412)4.30563985
34meiotic nuclear division (GO:0007126)4.22778810
35platelet dense granule organization (GO:0060155)4.18997565
36cell recognition (GO:0008037)4.17682872
37germ cell development (GO:0007281)4.15115415
38ventricular system development (GO:0021591)4.12278465
39organic cation transport (GO:0015695)4.07340729
40calcium ion-dependent exocytosis (GO:0017156)4.03542057
41centriole replication (GO:0007099)3.89851365
42protein localization to cilium (GO:0061512)3.89734631
43axoneme assembly (GO:0035082)3.86097816
44intraciliary transport (GO:0042073)3.81701786
45fucose catabolic process (GO:0019317)3.77856759
46L-fucose metabolic process (GO:0042354)3.77856759
47L-fucose catabolic process (GO:0042355)3.77856759
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.74733374
49respiratory chain complex IV assembly (GO:0008535)3.72303986
50monoubiquitinated protein deubiquitination (GO:0035520)3.71969010
51establishment of protein localization to Golgi (GO:0072600)3.70885303
52lactate metabolic process (GO:0006089)3.70253658
53cellular ketone body metabolic process (GO:0046950)3.64990266
54cytochrome complex assembly (GO:0017004)3.63676680
55meiotic cell cycle (GO:0051321)3.63393157
56inositol phosphate catabolic process (GO:0071545)3.58837027
57protein targeting to Golgi (GO:0000042)3.55964443
58synapsis (GO:0007129)3.52958212
59seminiferous tubule development (GO:0072520)3.51770197
60prenylation (GO:0097354)3.48227413
61protein prenylation (GO:0018342)3.48227413
62multicellular organismal reproductive process (GO:0048609)3.45084448
63meiosis I (GO:0007127)3.43446065
64indolalkylamine metabolic process (GO:0006586)3.43015998
65ketone body metabolic process (GO:1902224)3.35053771
66regulation of glucokinase activity (GO:0033131)3.34951662
67regulation of hexokinase activity (GO:1903299)3.34951662
68cilium organization (GO:0044782)3.29494104
69inositol phosphate dephosphorylation (GO:0046855)3.25391571
70phosphorylated carbohydrate dephosphorylation (GO:0046838)3.25391571
71cilium assembly (GO:0042384)3.22757063
72dopamine transport (GO:0015872)3.22717969
73regulation of microtubule-based movement (GO:0060632)3.19747119
74retrograde transport, vesicle recycling within Golgi (GO:0000301)3.17478332
75microtubule severing (GO:0051013)3.16239002
76detection of light stimulus involved in visual perception (GO:0050908)3.09717093
77detection of light stimulus involved in sensory perception (GO:0050962)3.09717093
78regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.09003414
79positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.08391850
80cellular component assembly involved in morphogenesis (GO:0010927)3.07750628
81tryptophan catabolic process (GO:0006569)3.05907525
82indole-containing compound catabolic process (GO:0042436)3.05907525
83indolalkylamine catabolic process (GO:0046218)3.05907525
84negative regulation of inclusion body assembly (GO:0090084)3.05541949
85genitalia morphogenesis (GO:0035112)3.02565654
86regulation of meiosis I (GO:0060631)2.99972133
87preassembly of GPI anchor in ER membrane (GO:0016254)2.98848279
88single strand break repair (GO:0000012)2.98539468
89negative regulation of neurological system process (GO:0031645)2.97348784
90protein localization to Golgi apparatus (GO:0034067)2.96170186
91neural tube formation (GO:0001841)2.95016372
92brain morphogenesis (GO:0048854)2.94574092
93protein complex biogenesis (GO:0070271)2.94537302
94multicellular organismal development (GO:0007275)2.89204542
95positive regulation of meiosis (GO:0045836)2.86887795
96water-soluble vitamin biosynthetic process (GO:0042364)2.86838955
97regulation of acrosome reaction (GO:0060046)2.86473442
98DNA deamination (GO:0045006)2.85946992
99negative regulation of mast cell activation (GO:0033004)2.82971717
100mannosylation (GO:0097502)2.82937947
101glycerol ether metabolic process (GO:0006662)2.81597792
102cilium morphogenesis (GO:0060271)2.81483070
103replication fork processing (GO:0031297)2.78882083
104adaptation of signaling pathway (GO:0023058)2.77976004
105retinal cone cell development (GO:0046549)2.75960531
106tryptophan metabolic process (GO:0006568)2.73028581
107reflex (GO:0060004)2.72863112
108parental behavior (GO:0060746)2.72112167
109negative regulation of skeletal muscle tissue development (GO:0048642)2.69753703
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.65902111
111protein polyglutamylation (GO:0018095)2.65743745
112positive regulation of meiotic cell cycle (GO:0051446)2.65161622
113cellular response to gamma radiation (GO:0071480)2.62259287
114ether metabolic process (GO:0018904)2.59543305
115left/right pattern formation (GO:0060972)2.58955589
116behavioral response to ethanol (GO:0048149)2.58227534
117nucleoside diphosphate phosphorylation (GO:0006165)2.57292697
118regulation of inclusion body assembly (GO:0090083)2.57231283
119microtubule polymerization or depolymerization (GO:0031109)2.57037746
120meiotic cell cycle process (GO:1903046)2.56188924
121sister chromatid cohesion (GO:0007062)2.55459189
122mitochondrial respiratory chain complex assembly (GO:0033108)2.54401343
123reciprocal DNA recombination (GO:0035825)2.54092517
124reciprocal meiotic recombination (GO:0007131)2.54092517
125cornea development in camera-type eye (GO:0061303)2.53583333
126signal peptide processing (GO:0006465)2.53550147
127RNA destabilization (GO:0050779)2.53084144
128regulation of neurotransmitter uptake (GO:0051580)2.52195688
129modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.51009295
130positive regulation by organism of defense response of other organism involved in symbiotic interact2.51009295
131modulation by symbiont of host immune response (GO:0052553)2.51009295
132positive regulation by symbiont of host defense response (GO:0052509)2.51009295
133modulation by symbiont of host defense response (GO:0052031)2.51009295
134modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.51009295
135photoreceptor cell development (GO:0042461)2.47240782
136auditory receptor cell stereocilium organization (GO:0060088)2.47182989
137positive regulation of glycolytic process (GO:0045821)2.46908485
138polyol catabolic process (GO:0046174)2.46468946
139regulation of necroptotic process (GO:0060544)2.46005737
140kidney morphogenesis (GO:0060993)2.45726131
141NAD biosynthetic process (GO:0009435)2.44587218
142cellular biogenic amine catabolic process (GO:0042402)2.44149687
143amine catabolic process (GO:0009310)2.44149687
144S-adenosylmethionine metabolic process (GO:0046500)2.43913692
145peptidyl-histidine modification (GO:0018202)2.43592344
146regulation of centriole replication (GO:0046599)2.43521160
147dentate gyrus development (GO:0021542)2.42828573
148startle response (GO:0001964)2.42410884
149aggressive behavior (GO:0002118)2.41815828
150DNA double-strand break processing (GO:0000729)2.41073932
151intra-Golgi vesicle-mediated transport (GO:0006891)2.40083492
152double-strand break repair via homologous recombination (GO:0000724)2.39902956
153regulation of protein glycosylation (GO:0060049)2.39849372
154sequestering of actin monomers (GO:0042989)2.38799123
155photoreceptor cell maintenance (GO:0045494)2.37967359
156microtubule-based movement (GO:0007018)2.36789970
157gene silencing by RNA (GO:0031047)2.36048748
158negative regulation of necroptotic process (GO:0060546)2.34608206
159microglial cell activation (GO:0001774)2.25804021
160meiotic chromosome segregation (GO:0045132)2.20827767
161nonmotile primary cilium assembly (GO:0035058)2.20498336
162single-organism membrane fusion (GO:0044801)2.19599473
163organelle assembly (GO:0070925)2.15126603
164calcium ion import (GO:0070509)2.13767257
165superoxide anion generation (GO:0042554)2.13076843
166regulation of protein polyubiquitination (GO:1902914)2.11883062
167fusion of sperm to egg plasma membrane (GO:0007342)13.0022952
168cilium or flagellum-dependent cell motility (GO:0001539)12.5952151
169cell wall macromolecule metabolic process (GO:0044036)11.8135270
170cell wall macromolecule catabolic process (GO:0016998)11.8135270
171multicellular organism reproduction (GO:0032504)11.3913589
172acrosome assembly (GO:0001675)10.4601074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.98901375
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.23006014
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.00605207
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.24097667
5PCGF2_27294783_Chip-Seq_ESCs_Mouse3.09682116
6EZH2_22144423_ChIP-Seq_EOC_Human2.80790113
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.71216761
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40554320
9IGF1R_20145208_ChIP-Seq_DFB_Human2.38790574
10SUZ12_27294783_Chip-Seq_NPCs_Mouse2.36545622
11NFE2_27457419_Chip-Seq_LIVER_Mouse2.35936513
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32674596
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30503692
14PCGF2_27294783_Chip-Seq_NPCs_Mouse2.25263821
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.16392446
16EZH2_27294783_Chip-Seq_NPCs_Mouse1.98591774
17EWS_26573619_Chip-Seq_HEK293_Human1.97449119
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.96387789
19* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.89401510
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86494473
21TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.84454491
22EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.83446557
23BCAT_22108803_ChIP-Seq_LS180_Human1.77322531
24TAL1_26923725_Chip-Seq_HPCs_Mouse1.76844613
25P53_22387025_ChIP-Seq_ESCs_Mouse1.74365192
26NANOG_18555785_Chip-Seq_ESCs_Mouse1.74097524
27CRX_20693478_ChIP-Seq_RETINA_Mouse1.73761522
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72604657
29EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.72431552
30STAT1_17558387_ChIP-Seq_HELA_Human1.72366706
31OCT4_18555785_Chip-Seq_ESCs_Mouse1.70424571
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.67612176
33STAT3_18555785_Chip-Seq_ESCs_Mouse1.66641279
34SUZ12_18555785_Chip-Seq_ESCs_Mouse1.64440634
35P300_18555785_Chip-Seq_ESCs_Mouse1.62602294
36KDM2B_26808549_Chip-Seq_REH_Human1.62477742
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.61441345
38RUNX1_27457419_Chip-Seq_LIVER_Mouse1.61427747
39CMYC_18555785_Chip-Seq_ESCs_Mouse1.61207165
40AR_25329375_ChIP-Seq_VCAP_Human1.60907297
41STAT3_23295773_ChIP-Seq_U87_Human1.60629644
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.59601839
43KLF4_18555785_Chip-Seq_ESCs_Mouse1.58935145
44ESRRB_18555785_Chip-Seq_ESCs_Mouse1.58545885
45KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.58208236
46CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.57591541
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56724954
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55949490
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55831089
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55045779
51E2F1_18555785_Chip-Seq_ESCs_Mouse1.52811342
52OCT4_21477851_ChIP-Seq_ESCs_Mouse1.52224194
53NMYC_18555785_Chip-Seq_ESCs_Mouse1.51096354
54TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.50791698
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48313839
56RNF2_27304074_Chip-Seq_NSC_Mouse1.47953174
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47131439
58PU1_27457419_Chip-Seq_LIVER_Mouse1.46565896
59SMAD1_18555785_Chip-Seq_ESCs_Mouse1.46261637
60GBX2_23144817_ChIP-Seq_PC3_Human1.45627037
61CTCF_18555785_Chip-Seq_ESCs_Mouse1.45385305
62ZFX_18555785_Chip-Seq_ESCs_Mouse1.45044631
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44546099
64SOX2_19829295_ChIP-Seq_ESCs_Human1.44001538
65NANOG_19829295_ChIP-Seq_ESCs_Human1.44001538
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.43426226
67SOX2_18555785_Chip-Seq_ESCs_Mouse1.42978315
68ELK1_19687146_ChIP-ChIP_HELA_Human1.40539112
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.40513192
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39577891
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.39382328
72TAF15_26573619_Chip-Seq_HEK293_Human1.38777536
73TCF4_22108803_ChIP-Seq_LS180_Human1.38630968
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38629727
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37264394
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.36696685
77VDR_22108803_ChIP-Seq_LS180_Human1.34970361
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33756411
79TP53_22573176_ChIP-Seq_HFKS_Human1.33492934
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33427586
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33427586
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32860436
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.31923771
84ER_23166858_ChIP-Seq_MCF-7_Human1.31224534
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.29216530
86CDX2_22108803_ChIP-Seq_LS180_Human1.28847763
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28828832
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27344592
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.27168565
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25556616
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24608995
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24537731
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24517140
94RUNX2_22187159_ChIP-Seq_PCA_Human1.23222725
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.22253246
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.21672955
97ZNF274_21170338_ChIP-Seq_K562_Hela1.20177197
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19219395
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18523106
100CBP_20019798_ChIP-Seq_JUKART_Human1.18006430
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18006430
102EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17834358
103GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.16744139
104GATA3_21867929_ChIP-Seq_CD8_Mouse1.14778273
105ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13898022
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13665736
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.13665736
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13256218
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.11719791
110GATA3_21867929_ChIP-Seq_TH1_Mouse1.11518010
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10970726
112GF1_26923725_Chip-Seq_HPCs_Mouse1.10884926
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10580133
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09783238
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09713057
116SMAD4_21799915_ChIP-Seq_A2780_Human1.09509912
117WDR5_24793694_ChIP-Seq_LNCAP_Human1.09493953
118RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09439437
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08718384
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08457384
121ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06580425
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06294047
123SCL_19346495_ChIP-Seq_HPC-7_Human1.06166761
124P300_19829295_ChIP-Seq_ESCs_Human1.06033824
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05740991
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05684383
127FUS_26573619_Chip-Seq_HEK293_Human1.04904007
128EST1_17652178_ChIP-ChIP_JURKAT_Human1.04727782
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04371016
130Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04105634
131FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03759047
132GATA1_26923725_Chip-Seq_HPCs_Mouse1.02915170
133KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.02541039
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02532640
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02114984
136AR_20517297_ChIP-Seq_VCAP_Human1.01754202
137VDR_23849224_ChIP-Seq_CD4+_Human0.99410263
138BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99313422
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98507354
140GF1B_26923725_Chip-Seq_HPCs_Mouse0.97412013
141* TCF4_23295773_ChIP-Seq_U87_Human0.96486035
142CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94875238
143CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92012066
144SOX2_22085726_ChIP-Seq_NPCs_Mouse0.91499814
145* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89705488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.73397872
2MP0008877_abnormal_DNA_methylation4.51397158
3MP0001929_abnormal_gametogenesis4.35258127
4MP0002210_abnormal_sex_determination3.26751875
5MP0005670_abnormal_white_adipose2.99920316
6MP0003195_calcinosis2.90367459
7MP0008057_abnormal_DNA_replication2.83265142
8MP0003787_abnormal_imprinting2.60859033
9MP0001145_abnormal_male_reproductive2.60012505
10MP0002837_dystrophic_cardiac_calcinosis2.49821095
11MP0002161_abnormal_fertility/fecundity2.36477043
12MP0003011_delayed_dark_adaptation2.32205869
13MP0000653_abnormal_sex_gland2.28343160
14MP0002102_abnormal_ear_morphology2.20904178
15MP0006292_abnormal_olfactory_placode2.19348772
16MP0002653_abnormal_ependyma_morphology2.17646688
17MP0000427_abnormal_hair_cycle2.15612858
18MP0005645_abnormal_hypothalamus_physiol2.10592764
19MP0005410_abnormal_fertilization11.2458752
20MP0008058_abnormal_DNA_repair1.96315771
21MP0001986_abnormal_taste_sensitivity1.96223368
22MP0005084_abnormal_gallbladder_morpholo1.88596016
23MP0001835_abnormal_antigen_presentation1.86449499
24MP0002254_reproductive_system_inflammat1.79673574
25MP0005174_abnormal_tail_pigmentation1.71716077
26MP0000015_abnormal_ear_pigmentation1.69549901
27MP0002277_abnormal_respiratory_mucosa1.64288562
28MP0002132_abnormal_respiratory_system1.60088272
29MP0005551_abnormal_eye_electrophysiolog1.59631920
30MP0009785_altered_susceptibility_to1.56613518
31MP0001968_abnormal_touch/_nociception1.52472306
32MP0002160_abnormal_reproductive_system1.48959802
33MP0006054_spinal_hemorrhage1.46339101
34MP0003950_abnormal_plasma_membrane1.40522982
35MP0002282_abnormal_trachea_morphology1.37444046
36MP0008007_abnormal_cellular_replicative1.35495597
37MP0004142_abnormal_muscle_tone1.34653676
38MP0001501_abnormal_sleep_pattern1.32005585
39MP0008875_abnormal_xenobiotic_pharmacok1.29334182
40MP0002148_abnormal_hypersensitivity_rea1.28731231
41MP0002909_abnormal_adrenal_gland1.28717762
42MP0001188_hyperpigmentation1.28698262
43MP0008872_abnormal_physiological_respon1.26732007
44MP0003136_yellow_coat_color1.26038612
45MP0000631_abnormal_neuroendocrine_gland1.25320968
46MP0009697_abnormal_copulation1.22600786
47MP0003718_maternal_effect1.21682781
48MP0009745_abnormal_behavioral_response1.20836248
49MP0005253_abnormal_eye_physiology1.20707510
50MP0005671_abnormal_response_to1.19652674
51MP0005646_abnormal_pituitary_gland1.19520969
52MP0004215_abnormal_myocardial_fiber1.18336509
53MP0005167_abnormal_blood-brain_barrier1.17308282
54MP0009780_abnormal_chondrocyte_physiolo1.15052026
55MP0003252_abnormal_bile_duct1.13936366
56MP0005623_abnormal_meninges_morphology1.13750355
57MP0008995_early_reproductive_senescence1.11173999
58MP0010386_abnormal_urinary_bladder1.10684591
59MP0000371_diluted_coat_color1.10480720
60MP0005409_darkened_coat_color1.10441524
61MP0002693_abnormal_pancreas_physiology1.08661631
62MP0001984_abnormal_olfaction1.08389231
63MP0001486_abnormal_startle_reflex1.06387159
64MP0002938_white_spotting1.05453694
65MP0010094_abnormal_chromosome_stability1.04780382
66MP0004134_abnormal_chest_morphology1.04213352
67MP0001529_abnormal_vocalization1.03752308
68MP0009046_muscle_twitch1.03428998
69MP0005075_abnormal_melanosome_morpholog1.03248357
70MP0004147_increased_porphyrin_level1.03239689
71MP0005389_reproductive_system_phenotype1.02174187
72MP0003121_genomic_imprinting1.01990960
73MP0006276_abnormal_autonomic_nervous1.01518680
74MP0003172_abnormal_lysosome_physiology1.01484983
75MP0004043_abnormal_pH_regulation1.01061761
76MP0001485_abnormal_pinna_reflex1.00985900
77MP0005171_absent_coat_pigmentation1.00384325
78MP0002272_abnormal_nervous_system1.00167859
79MP0003786_premature_aging1.00142213
80MP0005332_abnormal_amino_acid0.99705861
81MP0005408_hypopigmentation0.99147764
82MP0008775_abnormal_heart_ventricle0.98212617
83MP0004924_abnormal_behavior0.98102619
84MP0005386_behavior/neurological_phenoty0.98102619
85MP0004782_abnormal_surfactant_physiolog0.97866185
86MP0001944_abnormal_pancreas_morphology0.96910969
87MP0005025_abnormal_response_to0.95416601
88MP0001324_abnormal_eye_pigmentation0.94961957
89MP0000013_abnormal_adipose_tissue0.94113983
90MP0000230_abnormal_systemic_arterial0.94097008
91MP0010678_abnormal_skin_adnexa0.94049873
92MP0002419_abnormal_innate_immunity0.93820460
93MP0004484_altered_response_of0.93749001
94MP0000372_irregular_coat_pigmentation0.93058114
95MP0005647_abnormal_sex_gland0.92561215
96MP0002736_abnormal_nociception_after0.92370667
97MP0002723_abnormal_immune_serum0.92274914
98MP0003315_abnormal_perineum_morphology0.90769001
99MP0006036_abnormal_mitochondrial_physio0.90180270
100MP0005220_abnormal_exocrine_pancreas0.90074737
101MP0005387_immune_system_phenotype0.88748829
102MP0001790_abnormal_immune_system0.88748829
103MP0002229_neurodegeneration0.87896653
104MP0001119_abnormal_female_reproductive0.87894503
105MP0003646_muscle_fatigue0.87639465
106MP0006082_CNS_inflammation0.87559739
107MP0002876_abnormal_thyroid_physiology0.87513521
108MP0005085_abnormal_gallbladder_physiolo0.87171094
109MP0001764_abnormal_homeostasis0.86696684
110MP0002452_abnormal_antigen_presenting0.84981697
111MP0002405_respiratory_system_inflammati0.84897580
112MP0002166_altered_tumor_susceptibility0.84555509
113MP0003724_increased_susceptibility_to0.84382775
114MP0005000_abnormal_immune_tolerance0.83672624
115MP0002163_abnormal_gland_morphology0.83142758
116MP0001905_abnormal_dopamine_level0.80409795
117MP0010329_abnormal_lipoprotein_level0.80336692
118MP0004808_abnormal_hematopoietic_stem0.80180472
119MP0003656_abnormal_erythrocyte_physiolo0.79708425
120MP0001800_abnormal_humoral_immune0.79589718
121MP0001819_abnormal_immune_cell0.79404857
122MP0003633_abnormal_nervous_system0.78985961
123MP0005503_abnormal_tendon_morphology0.78321400
124MP0002420_abnormal_adaptive_immunity0.78008308
125MP0001756_abnormal_urination0.77844005
126MP0001970_abnormal_pain_threshold0.77150125
127MP0002095_abnormal_skin_pigmentation0.76952586
128MP0004019_abnormal_vitamin_homeostasis0.74492628
129MP0003763_abnormal_thymus_physiology0.74159370
130MP0000569_abnormal_digit_pigmentation0.73105698
131MP0004381_abnormal_hair_follicle0.70716248
132MP0003943_abnormal_hepatobiliary_system0.70169131
133MP0002638_abnormal_pupillary_reflex0.67869955
134MP0002928_abnormal_bile_duct0.66981854
135MP0003436_decreased_susceptibility_to0.60582611
136MP0005379_endocrine/exocrine_gland_phen0.59664173
137MP0005367_renal/urinary_system_phenotyp0.58983592
138MP0000516_abnormal_urinary_system0.58983592
139MP0002398_abnormal_bone_marrow0.58544997
140MP0000716_abnormal_immune_system0.58487556
141MP0000685_abnormal_immune_system0.58219595
142MP0009764_decreased_sensitivity_to0.57232039
143MP0005310_abnormal_salivary_gland0.55903898
144MP0009250_abnormal_appendicular_skeleto0.55351108
145MP0005391_vision/eye_phenotype0.54470556
146MP0003878_abnormal_ear_physiology0.53998979
147MP0005377_hearing/vestibular/ear_phenot0.53998979
148MP0005195_abnormal_posterior_eye0.52322879
149MP0003890_abnormal_embryonic-extraembry0.52245733
150MP0006072_abnormal_retinal_apoptosis0.51394550
151MP0002249_abnormal_larynx_morphology0.50919590
152MP0001963_abnormal_hearing_physiology0.50291743
153MP0000681_abnormal_thyroid_gland0.49123099
154MP0000383_abnormal_hair_follicle0.47975132
155MP0000026_abnormal_inner_ear0.46817352
156MP0001845_abnormal_inflammatory_respons0.46024357

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.02487042
2Abnormal respiratory epithelium morphology (HP:0012253)7.68525516
3Abnormal respiratory motile cilium morphology (HP:0005938)7.68525516
4Abnormal ciliary motility (HP:0012262)6.88334562
5Rhinitis (HP:0012384)6.37957500
6Chronic bronchitis (HP:0004469)5.52312668
7Nasal polyposis (HP:0100582)4.90080559
8Infertility (HP:0000789)4.29124796
9Nephronophthisis (HP:0000090)4.00072033
10Bronchiectasis (HP:0002110)3.95406997
11Abnormality of the nasal mucosa (HP:0000433)3.93524768
12Medial flaring of the eyebrow (HP:0010747)3.59457513
13Bronchitis (HP:0012387)3.55585151
14Recurrent sinusitis (HP:0011108)3.36241475
15Abnormality of the renal medulla (HP:0100957)3.22741169
16Hyperventilation (HP:0002883)3.15689446
17Tubulointerstitial nephritis (HP:0001970)3.12541893
18Hypothermia (HP:0002045)3.01160328
19Abnormal spermatogenesis (HP:0008669)2.86132150
20Gaze-evoked nystagmus (HP:0000640)2.81156834
21Intestinal atresia (HP:0011100)2.76306501
22Type II lissencephaly (HP:0007260)2.73040746
23Abnormal rod and cone electroretinograms (HP:0008323)2.70387201
24Molar tooth sign on MRI (HP:0002419)2.69075530
25Abnormality of midbrain morphology (HP:0002418)2.69075530
26Congenital primary aphakia (HP:0007707)2.68418306
27Recurrent otitis media (HP:0000403)2.67191107
28Gait imbalance (HP:0002141)2.62155367
29Albinism (HP:0001022)2.61625091
30True hermaphroditism (HP:0010459)2.59673870
313-Methylglutaconic aciduria (HP:0003535)2.58173978
32Postaxial foot polydactyly (HP:0001830)2.56256699
33Progressive macrocephaly (HP:0004481)2.53683234
34Thyroiditis (HP:0100646)2.53342181
35Large for gestational age (HP:0001520)2.51346719
36Stomatitis (HP:0010280)2.50837489
37Pancreatic fibrosis (HP:0100732)2.41824520
38Nephrogenic diabetes insipidus (HP:0009806)2.40908916
39Azoospermia (HP:0000027)2.40645431
40Methylmalonic acidemia (HP:0002912)2.34417374
41Furrowed tongue (HP:0000221)2.31808929
42Ketoacidosis (HP:0001993)2.29833191
43Volvulus (HP:0002580)2.28415555
44Methylmalonic aciduria (HP:0012120)2.28182434
45Abolished electroretinogram (ERG) (HP:0000550)2.26962069
46Type 2 muscle fiber atrophy (HP:0003554)2.26935987
47Absent speech (HP:0001344)2.26665178
48Neoplasm of the adrenal cortex (HP:0100641)2.25702288
49Recurrent bronchitis (HP:0002837)2.24433472
50Pendular nystagmus (HP:0012043)2.22554017
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22038842
52Dyschromatopsia (HP:0007641)2.19941441
53Tubulointerstitial abnormality (HP:0001969)2.18344284
54Fibular hypoplasia (HP:0003038)2.17461348
55Absent frontal sinuses (HP:0002688)2.16479743
56Abnormality of the renal cortex (HP:0011035)2.15821666
57Abnormality of macular pigmentation (HP:0008002)2.15781850
58Renal cortical cysts (HP:0000803)2.15074583
59Aplasia/Hypoplasia of the fovea (HP:0008060)2.15059814
60Hypoplasia of the fovea (HP:0007750)2.15059814
61Acute necrotizing encephalopathy (HP:0006965)2.13575576
62Fair hair (HP:0002286)2.13566827
63Gonadotropin excess (HP:0000837)2.13496331
64Decreased central vision (HP:0007663)2.12755483
65Chronic hepatic failure (HP:0100626)2.11561121
66Stomach cancer (HP:0012126)2.11494257
67Mitochondrial inheritance (HP:0001427)2.11175222
68Papillary thyroid carcinoma (HP:0002895)2.11146343
69Hemiparesis (HP:0001269)2.10142176
70Widely spaced teeth (HP:0000687)2.09949703
71Congenital hepatic fibrosis (HP:0002612)2.08686096
72Increased CSF lactate (HP:0002490)2.08620045
73Poor coordination (HP:0002370)2.05825447
74Tubular atrophy (HP:0000092)2.05070419
75Increased corneal curvature (HP:0100692)2.03609213
76Keratoconus (HP:0000563)2.03609213
77Abnormality of vitamin B metabolism (HP:0004340)2.02674286
78Chronic sinusitis (HP:0011109)2.01751881
79Aqueductal stenosis (HP:0002410)2.01547547
80Sclerocornea (HP:0000647)2.01464046
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.4141571
82Dynein arm defect of respiratory motile cilia (HP:0012255)10.7031688
83Absent/shortened dynein arms (HP:0200106)10.7031688
84Renal dysplasia (HP:0000110)1.99966657
85Congenital sensorineural hearing impairment (HP:0008527)1.97914213
86Optic nerve hypoplasia (HP:0000609)1.95903160
87Acute encephalopathy (HP:0006846)1.94518386
88Hematochezia (HP:0002573)1.93704348
89Male infertility (HP:0003251)1.92666793
90Anencephaly (HP:0002323)1.92451646
91Polyuria (HP:0000103)1.91788986
92Constricted visual fields (HP:0001133)1.91710531
93Aplasia/Hypoplasia of the lens (HP:0008063)1.90240951
94Abnormal biliary tract physiology (HP:0012439)1.88600111
95Bile duct proliferation (HP:0001408)1.88600111
96Chromsome breakage (HP:0040012)1.87033426
97Congenital, generalized hypertrichosis (HP:0004540)1.85978105
98Cerebellar dysplasia (HP:0007033)1.84311445
99Severe visual impairment (HP:0001141)1.83889618
100Muscle fiber atrophy (HP:0100295)1.83830832
101Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83169614
102Congenital stationary night blindness (HP:0007642)1.82535630
103Hypomagnesemia (HP:0002917)1.81577046
104Postaxial hand polydactyly (HP:0001162)1.81131498
105Attenuation of retinal blood vessels (HP:0007843)1.80809122
106Abnormality of the fovea (HP:0000493)1.80495961
107Hepatic necrosis (HP:0002605)1.80062339
108Febrile seizures (HP:0002373)1.79302857
109Retrobulbar optic neuritis (HP:0100654)1.79167184
110Optic neuritis (HP:0100653)1.79167184
111Weak cry (HP:0001612)1.79103435
112Vaginal atresia (HP:0000148)1.78803820
113Genital tract atresia (HP:0001827)1.78419994
114Lipid accumulation in hepatocytes (HP:0006561)1.77600154
115Pancreatic cysts (HP:0001737)1.77582529
116Facial cleft (HP:0002006)1.77170590
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.76400908
118Median cleft lip (HP:0000161)1.75942808
119Abnormality of renal resorption (HP:0011038)1.75656166
120Hepatocellular necrosis (HP:0001404)1.75550014
121Generalized hypopigmentation of hair (HP:0011358)1.75162380
122Neoplasm of the tracheobronchial system (HP:0100552)1.71636317
123Nonprogressive disorder (HP:0003680)1.71238246
124Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70088225
125Ketosis (HP:0001946)1.69284932
126Hamartoma of the eye (HP:0010568)1.68022931
127Astigmatism (HP:0000483)1.67921738
128Abnormality of molar (HP:0011077)1.67831199
129Abnormality of molar morphology (HP:0011070)1.67831199
130Bony spicule pigmentary retinopathy (HP:0007737)1.67518676
131Abnormality of permanent molar morphology (HP:0011071)1.66487172
132Abnormality of the dental root (HP:0006486)1.66487172
133Taurodontia (HP:0000679)1.66487172
134Hyperinsulinemic hypoglycemia (HP:0000825)1.65759193
135Abnormal albumin level (HP:0012116)1.65506084
136Hypoalbuminemia (HP:0003073)1.65506084
137Abnormal protein N-linked glycosylation (HP:0012347)1.64205224
138Abnormal glycosylation (HP:0012345)1.64205224
139Stage 5 chronic kidney disease (HP:0003774)1.63939834
140Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.61224441
141Occipital encephalocele (HP:0002085)1.59011483
142Easy fatigability (HP:0003388)1.58598028
143Tongue fasciculations (HP:0001308)1.57693424
144Abnormality of the neuromuscular junction (HP:0003398)1.57679909
145Fatigable weakness (HP:0003473)1.57679909
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.57070079
147Abnormality of the dental pulp (HP:0006479)1.56963388
148Short thorax (HP:0010306)1.53059240
149Cone-rod dystrophy (HP:0000548)1.52711731
150Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.52307596
151Impulsivity (HP:0100710)1.52170246
152Vitreoretinal degeneration (HP:0000655)1.51032540
153Short femoral neck (HP:0100864)1.50628373
154Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.50409836
155Absent epiphyses (HP:0010577)1.50409836
156Supernumerary spleens (HP:0009799)1.49276913
157Cystic liver disease (HP:0006706)1.49188472
158Male pseudohermaphroditism (HP:0000037)1.49177341
159Polydipsia (HP:0001959)1.48383783
160Abnormal drinking behavior (HP:0030082)1.48383783
161Retinitis pigmentosa (HP:0000510)1.48357126
162Aplasia/Hypoplasia of the uvula (HP:0010293)1.47539459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.22680925
2PDK47.06137519
3PDK37.06137519
4PDK24.93364248
5STK163.62436705
6MAP4K22.74399667
7TESK12.30181883
8MST42.29800820
9ACVR1B2.22770260
10TXK2.20679478
11WNK32.06206576
12FGFR22.02834762
13ZAK1.90035436
14STK391.84494632
15EIF2AK31.80913912
16PLK21.80861117
17WNK41.80199158
18YES11.79074758
19MAPK131.71690642
20INSRR1.68337110
21MAP3K141.60310502
22MAP3K41.59609749
23MUSK1.55913913
24OXSR11.54676801
25ICK1.53747882
26PAK31.51776237
27GRK11.48368217
28PLK41.48060304
29PRKD31.37498541
30IRAK11.34622897
31PTK2B1.31488862
32BMPR1B1.31188678
33IRAK41.30593627
34CASK1.28674129
35BRSK21.22530177
36CDK121.20910213
37PINK11.15715071
38TEC1.14010622
39NEK61.13602878
40PRKCE1.10513438
41PLK31.04633087
42MAP4K11.03756016
43MAP2K71.01976966
44STK31.01474924
45CAMKK20.99737830
46EIF2AK20.98087935
47TRIM280.95904479
48FER0.95220839
49MAP3K120.94254842
50TNIK0.93702856
51CSNK1G10.92669693
52DAPK20.91269852
53ADRBK20.89964299
54ADRBK10.88503441
55CSNK1G20.88350110
56BMPR20.87786866
57MAP2K60.87012725
58SRPK10.86571097
59TAOK30.86472418
60KIT0.85802130
61CSNK1G30.85072409
62STK38L0.84792776
63MKNK20.84587830
64CDK30.84115853
65TAF10.81909908
66IRAK20.80094163
67PIK3CA0.78512401
68NTRK30.77357335
69PNCK0.77011833
70WNK10.76536084
71MAP3K30.73198676
72NUAK10.72004542
73MAP3K20.71472559
74CCNB10.71414355
75GRK50.69977546
76MST1R0.69550802
77ATR0.69517996
78STK240.69491687
79CSNK1A1L0.67173684
80ERBB30.66978285
81TAOK20.63868759
82MAPK150.63209800
83PHKG20.62533095
84PHKG10.62533095
85NEK20.62527602
86IKBKB0.59619367
87ZAP700.59340525
88RIPK10.59306128
89PRKCG0.58113622
90WEE10.57567289
91TIE10.57137770
92VRK10.56476503
93CLK10.56235167
94STK380.56091357
95PDK10.55144897
96AKT30.54174376
97BTK0.53921876
98FGFR30.52896085
99PASK0.52544929
100MKNK10.52288593
101MAP2K30.51519604
102PRKAA20.51475148
103SGK20.51264127
104IRAK30.51115609
105TRPM70.50803210
106BCR0.49935487
107NLK0.45877020
108DYRK20.45723117
109CHEK20.44849747
110IKBKE0.44319162
111ATM0.44178298
112SIK30.43957283
113ITK0.42900671
114TLK10.42627570
115EIF2AK10.41349811
116RPS6KB10.40710291
117PIM10.39343617
118STK110.39165749
119PRKD20.38730719
120TNK20.38596450
121CHUK0.38315256
122PRKG10.37624996
123PRKCI0.37274849
124EPHA40.36804464
125SYK0.36366199
126PRKG20.36065556
127PIK3CG0.35484102
128STK40.35137509
129CHEK10.34573292
130TGFBR10.33799542
131PRKCQ0.33375296
132FLT30.32853656
133LATS10.32049223
134JAK30.31736000
135PRPF4B0.31353897
136DYRK1B0.31242706
137NEK90.30877315
138CAMK1G0.30664221
139CSNK1D0.30298254
140LYN0.29805057
141RPS6KA50.29705716
142LCK0.29596252
143PKN10.29229459
144MARK30.28985212
145CSK0.28973395
146PBK0.28825927
147PRKAA10.28611510
148ABL10.28341459
149PRKACA0.28193475
150VRK20.28152850
151TGFBR20.27912172
152GRK70.27762865
153BCKDK0.27332168

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.49592103
2Fanconi anemia pathway_Homo sapiens_hsa034603.47521998
3Basal transcription factors_Homo sapiens_hsa030223.46248352
4Phototransduction_Homo sapiens_hsa047443.17738491
5Maturity onset diabetes of the young_Homo sapiens_hsa049503.15289434
6Butanoate metabolism_Homo sapiens_hsa006502.87257144
7Vitamin B6 metabolism_Homo sapiens_hsa007502.67923450
8Autoimmune thyroid disease_Homo sapiens_hsa053202.39063122
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10379910
10Nitrogen metabolism_Homo sapiens_hsa009102.09527476
11Allograft rejection_Homo sapiens_hsa053302.08577022
12Oxidative phosphorylation_Homo sapiens_hsa001902.02434150
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.01086277
14Regulation of autophagy_Homo sapiens_hsa041401.95443134
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.94128208
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83653947
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82372014
18Linoleic acid metabolism_Homo sapiens_hsa005911.81484662
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80923244
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.80155615
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76195191
22Caffeine metabolism_Homo sapiens_hsa002321.75382315
23Homologous recombination_Homo sapiens_hsa034401.71541241
24Measles_Homo sapiens_hsa051621.70854304
25Sphingolipid metabolism_Homo sapiens_hsa006001.69825697
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.69693215
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60842010
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.60647107
29Tryptophan metabolism_Homo sapiens_hsa003801.58165369
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.57494404
31Asthma_Homo sapiens_hsa053101.51982931
32Peroxisome_Homo sapiens_hsa041461.50756966
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50536736
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.49088961
35Graft-versus-host disease_Homo sapiens_hsa053321.40165704
36Purine metabolism_Homo sapiens_hsa002301.39902558
37Arachidonic acid metabolism_Homo sapiens_hsa005901.36626597
38Fatty acid biosynthesis_Homo sapiens_hsa000611.36388452
39Propanoate metabolism_Homo sapiens_hsa006401.33528109
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30250082
41Primary immunodeficiency_Homo sapiens_hsa053401.29413247
42ABC transporters_Homo sapiens_hsa020101.29068635
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28471444
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28195155
45RNA polymerase_Homo sapiens_hsa030201.27939248
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26289099
47Parkinsons disease_Homo sapiens_hsa050121.25698253
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.23413496
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23329607
50Pentose phosphate pathway_Homo sapiens_hsa000301.23164410
51Ether lipid metabolism_Homo sapiens_hsa005651.19986571
52Hematopoietic cell lineage_Homo sapiens_hsa046401.17696393
53mRNA surveillance pathway_Homo sapiens_hsa030151.15437291
54Olfactory transduction_Homo sapiens_hsa047401.14836977
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14098745
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12619374
57Herpes simplex infection_Homo sapiens_hsa051681.12306048
58Proteasome_Homo sapiens_hsa030501.11647414
59Pyruvate metabolism_Homo sapiens_hsa006201.09708295
60Selenocompound metabolism_Homo sapiens_hsa004501.09420711
61Glucagon signaling pathway_Homo sapiens_hsa049221.08599198
62Huntingtons disease_Homo sapiens_hsa050161.08487048
63Legionellosis_Homo sapiens_hsa051341.07836588
64NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06698569
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05222002
66Insulin secretion_Homo sapiens_hsa049111.04694500
67Influenza A_Homo sapiens_hsa051641.00886039
68Fatty acid elongation_Homo sapiens_hsa000620.98841617
69Rheumatoid arthritis_Homo sapiens_hsa053230.96020148
70Chemical carcinogenesis_Homo sapiens_hsa052040.94135223
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93537977
72Non-homologous end-joining_Homo sapiens_hsa034500.93332936
73beta-Alanine metabolism_Homo sapiens_hsa004100.89896852
74Circadian rhythm_Homo sapiens_hsa047100.89455406
75Antigen processing and presentation_Homo sapiens_hsa046120.88279994
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88200157
77Fatty acid metabolism_Homo sapiens_hsa012120.88003361
78Sulfur metabolism_Homo sapiens_hsa009200.86138263
79Taste transduction_Homo sapiens_hsa047420.85765883
80Dorso-ventral axis formation_Homo sapiens_hsa043200.85132859
81Protein export_Homo sapiens_hsa030600.84909660
82Mineral absorption_Homo sapiens_hsa049780.80334222
83One carbon pool by folate_Homo sapiens_hsa006700.79702524
84Vitamin digestion and absorption_Homo sapiens_hsa049770.78907322
85RNA degradation_Homo sapiens_hsa030180.78818403
86Nicotine addiction_Homo sapiens_hsa050330.78144888
87Glycerolipid metabolism_Homo sapiens_hsa005610.77136086
88Fructose and mannose metabolism_Homo sapiens_hsa000510.75989273
89Malaria_Homo sapiens_hsa051440.75875314
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75770941
91Serotonergic synapse_Homo sapiens_hsa047260.75067105
92TNF signaling pathway_Homo sapiens_hsa046680.73008107
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71437438
94Folate biosynthesis_Homo sapiens_hsa007900.70934616
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70638950
96Fatty acid degradation_Homo sapiens_hsa000710.69927226
97Alzheimers disease_Homo sapiens_hsa050100.66734036
98Type I diabetes mellitus_Homo sapiens_hsa049400.65223141
99N-Glycan biosynthesis_Homo sapiens_hsa005100.63530668
100Pyrimidine metabolism_Homo sapiens_hsa002400.63406648
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63198057
102Retinol metabolism_Homo sapiens_hsa008300.60399284
103Salivary secretion_Homo sapiens_hsa049700.58926986
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58838747
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58528114
106Toxoplasmosis_Homo sapiens_hsa051450.58224099
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.57087469
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57071494
109T cell receptor signaling pathway_Homo sapiens_hsa046600.56591215
110Morphine addiction_Homo sapiens_hsa050320.54966956
111Osteoclast differentiation_Homo sapiens_hsa043800.54696017
112Leishmaniasis_Homo sapiens_hsa051400.54617785
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52273885
114Steroid biosynthesis_Homo sapiens_hsa001000.52128468
115Inositol phosphate metabolism_Homo sapiens_hsa005620.51523482
116Circadian entrainment_Homo sapiens_hsa047130.51001485
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49717420
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48696842
119Phagosome_Homo sapiens_hsa041450.48007552
120p53 signaling pathway_Homo sapiens_hsa041150.46615809
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44223790
122Calcium signaling pathway_Homo sapiens_hsa040200.43951796
123Protein digestion and absorption_Homo sapiens_hsa049740.41434037
124Salmonella infection_Homo sapiens_hsa051320.41214814
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41097666
126African trypanosomiasis_Homo sapiens_hsa051430.40653400
127PPAR signaling pathway_Homo sapiens_hsa033200.40584945
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.40513942
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39968451
130GABAergic synapse_Homo sapiens_hsa047270.39860342
131Metabolic pathways_Homo sapiens_hsa011000.38829263
132RNA transport_Homo sapiens_hsa030130.38237248
133Oocyte meiosis_Homo sapiens_hsa041140.37656671
134Glutamatergic synapse_Homo sapiens_hsa047240.35755740
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35090434
136Cardiac muscle contraction_Homo sapiens_hsa042600.33958034
137Cell cycle_Homo sapiens_hsa041100.33787708
138B cell receptor signaling pathway_Homo sapiens_hsa046620.33708766
139Ovarian steroidogenesis_Homo sapiens_hsa049130.33606622
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33160351
141Staphylococcus aureus infection_Homo sapiens_hsa051500.33116113
142Tuberculosis_Homo sapiens_hsa051520.32066650
143Collecting duct acid secretion_Homo sapiens_hsa049660.31479164
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30569934
145Fat digestion and absorption_Homo sapiens_hsa049750.29409639
146Dopaminergic synapse_Homo sapiens_hsa047280.28990104
147Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27828313
148Glutathione metabolism_Homo sapiens_hsa004800.27021091
149Long-term depression_Homo sapiens_hsa047300.25088767

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