SPATA12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is expressed primarily in testis and may play a role in testicular development and spermatogenesis. The encoded protein may be upregulated in response to ultraviolet-C radiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.25257762
2DNA packaging (GO:0006323)8.81904432
3rRNA methylation (GO:0031167)8.75737107
4single strand break repair (GO:0000012)8.48017096
5microtubule depolymerization (GO:0007019)8.20600090
6sperm capacitation (GO:0048240)7.73817759
7plasma membrane fusion (GO:0045026)7.66145205
8spermatid development (GO:0007286)7.59949124
9rRNA modification (GO:0000154)7.59243891
10microtubule polymerization or depolymerization (GO:0031109)7.04513261
11sperm-egg recognition (GO:0035036)6.99051328
12protein targeting to Golgi (GO:0000042)6.91677156
13centriole replication (GO:0007099)6.72538243
14protein polyglutamylation (GO:0018095)6.72525304
15binding of sperm to zona pellucida (GO:0007339)6.71062677
16establishment of protein localization to Golgi (GO:0072600)6.58954290
17retrograde transport, vesicle recycling within Golgi (GO:0000301)6.34744513
18spermatid nucleus differentiation (GO:0007289)6.19933442
19response to pheromone (GO:0019236)6.09840974
20spermatogenesis (GO:0007283)6.07243878
21male gamete generation (GO:0048232)6.05339140
22multicellular organism reproduction (GO:0032504)6.01003167
23centriole assembly (GO:0098534)5.70432894
24regulation of centriole replication (GO:0046599)5.69162126
25phosphatidylethanolamine biosynthetic process (GO:0006646)5.68062921
26cell-cell recognition (GO:0009988)5.66080856
27gamete generation (GO:0007276)5.59918314
28axonemal dynein complex assembly (GO:0070286)5.56376035
29reproduction (GO:0000003)5.55226115
30microtubule severing (GO:0051013)5.34342053
31calcium ion-dependent exocytosis (GO:0017156)5.25561214
32phosphatidylethanolamine metabolic process (GO:0046337)5.24998422
33sexual reproduction (GO:0019953)5.13786560
34negative regulation of inclusion body assembly (GO:0090084)4.97165954
35protein localization to Golgi apparatus (GO:0034067)4.94026481
36regulation of cilium movement (GO:0003352)4.64477188
37motile cilium assembly (GO:0044458)4.59933976
38single fertilization (GO:0007338)4.59622229
39polyamine biosynthetic process (GO:0006596)4.54212505
40germ cell development (GO:0007281)4.47473512
41multicellular organismal reproductive process (GO:0048609)4.44753143
42cell wall macromolecule catabolic process (GO:0016998)4.34860633
43multicellular organismal movement (GO:0050879)4.29361746
44musculoskeletal movement (GO:0050881)4.29361746
45seminiferous tubule development (GO:0072520)4.22216100
46nuclear pore complex assembly (GO:0051292)4.20104472
47glomerular visceral epithelial cell development (GO:0072015)4.20005317
48cellular process involved in reproduction in multicellular organism (GO:0022412)4.14976310
49RNA destabilization (GO:0050779)4.14357052
50cilium or flagellum-dependent cell motility (GO:0001539)4.14277621
51chromatin silencing (GO:0006342)4.05442883
52cellular ketone body metabolic process (GO:0046950)4.00589729
53cell wall macromolecule metabolic process (GO:0044036)3.99135563
54nucleus organization (GO:0006997)3.92446559
55glomerular epithelial cell development (GO:0072310)3.90875194
56regulation of inclusion body assembly (GO:0090083)3.89514702
57fertilization (GO:0009566)3.87996156
58epithelial cilium movement (GO:0003351)3.85213427
59regulation of Rab GTPase activity (GO:0032313)3.77604513
60positive regulation of Rab GTPase activity (GO:0032851)3.77604513
61glycerol ether metabolic process (GO:0006662)3.69855822
62histone exchange (GO:0043486)3.59775732
63ketone body metabolic process (GO:1902224)3.50613589
64membrane protein intracellular domain proteolysis (GO:0031293)3.41818589
65ether metabolic process (GO:0018904)3.37904707
66organic cation transport (GO:0015695)3.34723773
67response to acidic pH (GO:0010447)3.31328631
68nuclear pore organization (GO:0006999)3.26942981
69cilium movement (GO:0003341)3.25406992
70pore complex assembly (GO:0046931)3.24257527
71regulation of transcription involved in cell fate commitment (GO:0060850)3.22186338
72microtubule nucleation (GO:0007020)3.21849988
73DNA conformation change (GO:0071103)3.19348182
74RNA methylation (GO:0001510)3.16146037
75homeostasis of number of cells within a tissue (GO:0048873)3.13537710
76tRNA methylation (GO:0030488)3.11820624
77positive regulation of guanylate cyclase activity (GO:0031284)2.98460094
78regulation of centrosome duplication (GO:0010824)2.95630460
79L-alpha-amino acid transmembrane transport (GO:1902475)2.92963720
80mitochondrial fission (GO:0000266)2.91084298
81centrosome duplication (GO:0051298)2.87973049
82regulation of microtubule-based movement (GO:0060632)2.87576544
83cellular biogenic amine biosynthetic process (GO:0042401)2.86746695
84cerebral cortex neuron differentiation (GO:0021895)2.79933165
85chaperone-mediated protein complex assembly (GO:0051131)2.78182291
86protein depolymerization (GO:0051261)2.76047008
87regulation of chromosome segregation (GO:0051983)2.74611439
88resolution of meiotic recombination intermediates (GO:0000712)2.74167293
89histone mRNA catabolic process (GO:0071044)2.72772412
90mitotic G1 DNA damage checkpoint (GO:0031571)2.71681693
91regulation of guanylate cyclase activity (GO:0031282)2.68606550
92cellular response to pH (GO:0071467)2.67492072
93multicellular organismal development (GO:0007275)2.65759705
94amine biosynthetic process (GO:0009309)2.65683262
95cell recognition (GO:0008037)2.61382433
96protein K48-linked deubiquitination (GO:0071108)2.61357937
97RNA localization (GO:0006403)2.60382734
98sperm motility (GO:0030317)11.0647977
99acrosome reaction (GO:0007340)10.3982308
100fusion of sperm to egg plasma membrane (GO:0007342)10.2316468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.27889726
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.34968695
3MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.91763925
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.48326940
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.32294455
6FUS_26573619_Chip-Seq_HEK293_Human2.54015909
7TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52105366
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.52105366
9CBP_20019798_ChIP-Seq_JUKART_Human2.50615207
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.50615207
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.38753735
12E2F7_22180533_ChIP-Seq_HELA_Human2.04661710
13UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.02194749
14VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.99720257
15* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99549098
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.96418303
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.93756457
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92084963
19PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.84951963
20RBPJ_21746931_ChIP-Seq_IB4_Human1.83269577
21ERA_21632823_ChIP-Seq_H3396_Human1.77772919
22ER_23166858_ChIP-Seq_MCF-7_Human1.77619912
23NANOG_20526341_ChIP-Seq_ESCs_Human1.76845454
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.76075278
25* SMAD4_21741376_ChIP-Seq_EPCs_Human1.74364771
26RAC3_21632823_ChIP-Seq_H3396_Human1.74190990
27MYC_19829295_ChIP-Seq_ESCs_Human1.72149168
28YY1_22570637_ChIP-Seq_MALME-3M_Human1.71956171
29P300_19829295_ChIP-Seq_ESCs_Human1.71455005
30EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.70628339
31HNFA_21074721_ChIP-Seq_CACO-2_Human1.70500126
32WDR5_24793694_ChIP-Seq_LNCAP_Human1.68422888
33CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.66958123
34ELF1_20517297_ChIP-Seq_JURKAT_Human1.66242889
35ZNF274_21170338_ChIP-Seq_K562_Hela1.65684411
36TDRD3_21172665_ChIP-Seq_MCF-7_Human1.65408985
37AUTS2_25519132_ChIP-Seq_293T-REX_Human1.64463666
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.64438814
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.63977761
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.62355103
41* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.55558319
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.55266490
43ETV1_20927104_ChIP-Seq_GIST48_Human1.51720357
44TAF15_26573619_Chip-Seq_HEK293_Human1.51076866
45SALL4_22934838_ChIP-ChIP_CD34+_Human1.49404247
46TAF2_19829295_ChIP-Seq_ESCs_Human1.45010229
47SOX2_19829295_ChIP-Seq_ESCs_Human1.43759483
48NANOG_19829295_ChIP-Seq_ESCs_Human1.43759483
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43135081
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.42252848
51CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41530065
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41521513
53PHF8_20622853_ChIP-Seq_HELA_Human1.40386607
54OCT4_20526341_ChIP-Seq_ESCs_Human1.39354696
55TP53_18474530_ChIP-ChIP_U2OS_Human1.39159145
56NFYB_21822215_ChIP-Seq_K562_Human1.38637515
57ERG_20517297_ChIP-Seq_VCAP_Human1.33622041
58PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.32887632
59GATA6_21074721_ChIP-Seq_CACO-2_Human1.30725991
60TBL1_22424771_ChIP-Seq_293T_Human1.28290575
61AR_25329375_ChIP-Seq_VCAP_Human1.27697298
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26765435
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.26108668
64CTCF_20526341_ChIP-Seq_ESCs_Human1.25140442
65GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.25013007
66VDR_22108803_ChIP-Seq_LS180_Human1.23532411
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21733200
68KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.21698427
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21489688
70SMAD4_21741376_ChIP-Seq_HESCs_Human1.21369966
71CEBPB_22108803_ChIP-Seq_LS180_Human1.21034985
72* SMAD3_21741376_ChIP-Seq_ESCs_Human1.20648263
73E2F1_17053090_ChIP-ChIP_MCF-7_Human1.19848338
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19834336
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19240840
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19025970
77RUNX1_26923725_Chip-Seq_HPCs_Mouse1.17209513
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16988992
79SOX2_22085726_ChIP-Seq_NPCs_Mouse1.15389212
80RUNX2_22187159_ChIP-Seq_PCA_Human1.14796849
81GF1_26923725_Chip-Seq_HPCs_Mouse1.13335729
82HOXB7_26014856_ChIP-Seq_BT474_Human1.11343682
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10805554
84P53_21459846_ChIP-Seq_SAOS-2_Human1.10755778
85SMAD4_21799915_ChIP-Seq_A2780_Human1.10529544
86CBP_21632823_ChIP-Seq_H3396_Human1.10125026
87NFYA_21822215_ChIP-Seq_K562_Human1.10096446
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08738328
89P300_27268052_Chip-Seq_Bcells_Human1.07694538
90* FOXH1_21741376_ChIP-Seq_EPCs_Human1.06546550
91* E2F1_20622854_ChIP-Seq_HELA_Human1.06491272
92KDM2B_26808549_Chip-Seq_REH_Human1.04720270
93BCL6_27268052_Chip-Seq_Bcells_Human1.04094415
94VDR_24787735_ChIP-Seq_THP-1_Human1.03409824
95P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.02999949
96FOXM1_23109430_ChIP-Seq_U2OS_Human1.02896217
97FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02723178
98* BCOR_27268052_Chip-Seq_Bcells_Human1.02152656
99PHF8_20622854_ChIP-Seq_HELA_Human1.01756815
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01654627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.14085162
2MP0002822_catalepsy5.02092387
3MP0005377_hearing/vestibular/ear_phenot4.64237205
4MP0003878_abnormal_ear_physiology4.64237205
5MP0003698_abnormal_male_reproductive3.69744244
6MP0002653_abnormal_ependyma_morphology3.58758870
7MP0001929_abnormal_gametogenesis3.44781637
8MP0003718_maternal_effect3.43167905
9MP0003011_delayed_dark_adaptation3.19385156
10MP0003941_abnormal_skin_development2.75559956
11MP0002161_abnormal_fertility/fecundity2.09216453
12MP0001485_abnormal_pinna_reflex2.01034849
13MP0005410_abnormal_fertilization10.2888412
14MP0003646_muscle_fatigue1.92289485
15MP0009840_abnormal_foam_cell1.81006059
16MP0009697_abnormal_copulation1.78288360
17MP0001348_abnormal_lacrimal_gland1.73952420
18MP0003077_abnormal_cell_cycle1.69614793
19MP0002132_abnormal_respiratory_system1.65655958
20MP0002210_abnormal_sex_determination1.65250326
21MP0005310_abnormal_salivary_gland1.57158566
22MP0010307_abnormal_tumor_latency1.54411706
23MP0000678_abnormal_parathyroid_gland1.52119727
24MP0004957_abnormal_blastocyst_morpholog1.49258103
25MP0005379_endocrine/exocrine_gland_phen1.48163410
26MP0002735_abnormal_chemical_nociception1.42769201
27MP0005451_abnormal_body_composition1.39248290
28MP0001145_abnormal_male_reproductive1.36274512
29MP0004233_abnormal_muscle_weight1.33991442
30MP0005395_other_phenotype1.30965893
31MP0002282_abnormal_trachea_morphology1.29290326
32MP0003693_abnormal_embryo_hatching1.28143645
33MP0008877_abnormal_DNA_methylation1.27883779
34MP0005248_abnormal_Harderian_gland1.25102418
35MP0000653_abnormal_sex_gland1.21108032
36MP0004742_abnormal_vestibular_system1.08872594
37MP0009115_abnormal_fat_cell1.06970081
38MP0001963_abnormal_hearing_physiology1.04188518
39MP0010094_abnormal_chromosome_stability1.02324061
40MP0003172_abnormal_lysosome_physiology0.99680584
41MP0001486_abnormal_startle_reflex0.99461395
42MP0002229_neurodegeneration0.96951388
43MP0002269_muscular_atrophy0.96260168
44MP0005666_abnormal_adipose_tissue0.95096379
45MP0005167_abnormal_blood-brain_barrier0.94889029
46MP0002090_abnormal_vision0.94148026
47MP0003879_abnormal_hair_cell0.91521442
48MP0005253_abnormal_eye_physiology0.90600027
49MP0001968_abnormal_touch/_nociception0.87913069
50MP0003828_pulmonary_edema0.85795843
51MP0004510_myositis0.84372145
52MP0002127_abnormal_cardiovascular_syste0.82234088
53MP0008007_abnormal_cellular_replicative0.80155775
54MP0000534_abnormal_ureter_morphology0.79792809
55MP0005083_abnormal_biliary_tract0.76445426
56MP0000026_abnormal_inner_ear0.76405120
57MP0005551_abnormal_eye_electrophysiolog0.73308114
58MP0009053_abnormal_anal_canal0.73209146
59MP0002736_abnormal_nociception_after0.68685182
60MP0008569_lethality_at_weaning0.63456123
61MP0000516_abnormal_urinary_system0.62366809
62MP0005367_renal/urinary_system_phenotyp0.62366809
63MP0002138_abnormal_hepatobiliary_system0.59986704
64MP0006292_abnormal_olfactory_placode0.59596945
65MP0003137_abnormal_impulse_conducting0.58749501
66MP0009278_abnormal_bone_marrow0.56357712
67MP0002249_abnormal_larynx_morphology0.55782069
68MP0001984_abnormal_olfaction0.55546145
69MP0004019_abnormal_vitamin_homeostasis0.53443647
70MP0003632_abnormal_nervous_system0.52979539
71MP0005332_abnormal_amino_acid0.51781430
72MP0000604_amyloidosis0.51682395
73MP0005058_abnormal_lysosome_morphology0.50301215
74MP0005408_hypopigmentation0.50107075
75MP0008961_abnormal_basal_metabolism0.49706072
76MP0003111_abnormal_nucleus_morphology0.48984123
77MP0005164_abnormal_response_to0.48512441
78MP0008770_decreased_survivor_rate0.48496121
79MP0001666_abnormal_nutrient_absorption0.47782088
80MP0000955_abnormal_spinal_cord0.47435859
81MP0000313_abnormal_cell_death0.47350397
82MP0001293_anophthalmia0.46085161
83MP0001545_abnormal_hematopoietic_system0.45957382
84MP0005397_hematopoietic_system_phenotyp0.45957382
85MP0002102_abnormal_ear_morphology0.45904363
86MP0001765_abnormal_ion_homeostasis0.45272469
87MP0009765_abnormal_xenobiotic_induced0.45044711
88MP0002254_reproductive_system_inflammat0.44813428
89MP0005391_vision/eye_phenotype0.43923518
90MP0003631_nervous_system_phenotype0.41340835
91MP0002067_abnormal_sensory_capabilities0.40200905
92MP0005595_abnormal_vascular_smooth0.40097821
93MP0002733_abnormal_thermal_nociception0.39950443
94MP0008057_abnormal_DNA_replication0.39701845
95MP0004085_abnormal_heartbeat0.39664968
96MP0008058_abnormal_DNA_repair0.38784162
97MP0002234_abnormal_pharynx_morphology0.37360405
98MP0001286_abnormal_eye_development0.37331406
99MP0008932_abnormal_embryonic_tissue0.37233500
100MP0000343_altered_response_to0.37034467

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)7.03477211
2Severe visual impairment (HP:0001141)6.74788247
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.58506415
4Absent/shortened dynein arms (HP:0200106)5.58506415
5Tubulointerstitial nephritis (HP:0001970)5.35486707
6Asymmetric septal hypertrophy (HP:0001670)4.86661524
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.20496741
8Attenuation of retinal blood vessels (HP:0007843)4.09057460
9Cone-rod dystrophy (HP:0000548)4.08899485
10Abnormal ciliary motility (HP:0012262)4.06564473
11Aplasia/Hypoplasia of the earlobes (HP:0009906)3.95007722
12Abnormal respiratory motile cilium physiology (HP:0012261)3.93605952
13Abnormality of macular pigmentation (HP:0008002)3.87648354
14Bony spicule pigmentary retinopathy (HP:0007737)3.85258105
15Abnormal respiratory motile cilium morphology (HP:0005938)3.70666531
16Abnormal respiratory epithelium morphology (HP:0012253)3.70666531
17Hyperkalemia (HP:0002153)3.62433804
18Resting tremor (HP:0002322)3.60666211
19Male infertility (HP:0003251)3.56649379
20Progressive sensorineural hearing impairment (HP:0000408)3.53260487
21Nasal polyposis (HP:0100582)3.52537198
22Hypoalphalipoproteinemia (HP:0003233)3.50257561
23Impulsivity (HP:0100710)3.49591269
24Abnormal spermatogenesis (HP:0008669)3.25765977
25Agnosia (HP:0010524)3.21096096
26Rhabdomyosarcoma (HP:0002859)3.20439829
27Aplasia/Hypoplasia of the sacrum (HP:0008517)3.11951879
28Azoospermia (HP:0000027)3.08148916
29Abnormality of the nasal mucosa (HP:0000433)3.06084941
30Infertility (HP:0000789)3.05600550
31Hypoplasia of the thymus (HP:0000778)2.85889761
32Renal Fanconi syndrome (HP:0001994)2.74091486
33Subcapsular cataract (HP:0000523)2.72974449
34Duodenal stenosis (HP:0100867)2.66776099
35Small intestinal stenosis (HP:0012848)2.66776099
36Abnormal rod and cone electroretinograms (HP:0008323)2.63634268
37Neoplasm of striated muscle (HP:0009728)2.63546310
38Multiple enchondromatosis (HP:0005701)2.61594878
39Chronic bronchitis (HP:0004469)2.61589300
40Renovascular hypertension (HP:0100817)2.61215541
41Progressive hearing impairment (HP:0001730)2.60658544
42Portal hypertension (HP:0001409)2.60622723
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.54788420
44Potter facies (HP:0002009)2.54558557
45Facial shape deformation (HP:0011334)2.54558557
46Menstrual irregularities (HP:0000858)2.54028712
47Tubulointerstitial abnormality (HP:0001969)2.52600246
48Abnormality of dental color (HP:0011073)2.44371267
49Rhinitis (HP:0012384)2.40441003
50Enlarged epiphyses (HP:0010580)2.38532732
51Nephronophthisis (HP:0000090)2.37926304
52Generalized aminoaciduria (HP:0002909)2.37780536
53Abnormality of the hepatic vasculature (HP:0006707)2.37758462
54Stage 5 chronic kidney disease (HP:0003774)2.37062818
55Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.30713790
56Absent epiphyses (HP:0010577)2.30713790
57Truncal obesity (HP:0001956)2.28003011
58Ependymoma (HP:0002888)2.24773119
59Postural instability (HP:0002172)2.22786417
60Abnormal urine output (HP:0012590)2.21601584
61Focal segmental glomerulosclerosis (HP:0000097)2.17903203
62Sloping forehead (HP:0000340)2.16928823
63Abnormality of the ileum (HP:0001549)2.15724116
64Polydipsia (HP:0001959)2.15008763
65Abnormal drinking behavior (HP:0030082)2.15008763
66Hypoplastic ischia (HP:0003175)2.14554819
67Insulin-resistant diabetes mellitus (HP:0000831)2.12422551
68Upper limb muscle weakness (HP:0003484)2.10747811
69Meckel diverticulum (HP:0002245)2.09075536
70Progressive cerebellar ataxia (HP:0002073)2.08381671
71Amelogenesis imperfecta (HP:0000705)2.08346688
72Unilateral renal agenesis (HP:0000122)2.08205288
73Abnormality of the duodenum (HP:0002246)2.06958623
74Birth length less than 3rd percentile (HP:0003561)2.02320709
75Abnormality of the ischium (HP:0003174)2.02078282
76Abnormality of the parathyroid morphology (HP:0011766)2.01775652
77Pendular nystagmus (HP:0012043)2.00826249
78Increased purine levels (HP:0004368)2.00396919
79Hyperuricemia (HP:0002149)2.00396919
80Abnormality of renal excretion (HP:0011036)1.97037516
81Decreased central vision (HP:0007663)1.93952730
82Bell-shaped thorax (HP:0001591)1.93184572
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.91146323
84Flattened epiphyses (HP:0003071)1.90829396
85Hypergonadotropic hypogonadism (HP:0000815)1.89398488
86Abnormality of the renal medulla (HP:0100957)1.89292174
87Sensory axonal neuropathy (HP:0003390)1.88323561
88Recurrent pneumonia (HP:0006532)1.87922009
89Hypolipoproteinemia (HP:0010981)1.86163278
90Polyuria (HP:0000103)1.85911942
91Hypophosphatemic rickets (HP:0004912)1.85471414
92Abnormality of renal resorption (HP:0011038)1.85246699
93Poor head control (HP:0002421)1.81750465
94Abnormality of potassium homeostasis (HP:0011042)1.79728976
95Osteomalacia (HP:0002749)1.76802393
96Abnormality of sulfur amino acid metabolism (HP:0004339)1.73975598
97Glomerulosclerosis (HP:0000096)1.73391110
98Recurrent corneal erosions (HP:0000495)1.73339673
99Nasal speech (HP:0001611)1.72376942
100Abnormality of the costochondral junction (HP:0000919)1.68974503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.90573741
2BRD44.25355453
3TESK13.73156225
4INSRR3.71878046
5DDR23.12626078
6PLK23.07510112
7PNCK2.66858936
8TTK2.62518250
9STK38L2.60446403
10STK382.01310184
11MST1R2.01253053
12PBK1.98665557
13CAMK1G1.97533104
14CCNB11.91607576
15MAP4K21.91123580
16ACVR1B1.74634900
17TNIK1.63874282
18BMPR1B1.52707650
19MST41.51446490
20WNK11.48832937
21EIF2AK31.48020660
22BUB11.39387221
23NEK61.37714926
24CDK121.36666667
25CDK71.29916994
26PIK3CG1.28036081
27MAPK151.17208447
28BRSK21.12993359
29PLK11.03031726
30ZAK1.01962926
31ERBB41.00658152
32NME10.97939090
33STK390.90494936
34BRAF0.89132233
35DYRK1B0.88313323
36MAP3K90.88077558
37PDPK10.87842795
38NUAK10.86351729
39CAMK1D0.86348152
40PDK10.85754789
41TYRO30.82864336
42SRPK10.82365483
43MAP3K130.78773753
44PTK2B0.75788842
45MKNK20.74744686
46TIE10.73749189
47PLK30.69260431
48CDC70.69219280
49STK160.67223307
50DYRK30.66528426
51MET0.66069472
52MUSK0.64292762
53BRSK10.64195359
54MAP3K80.60871505
55PRKG20.60046554
56PRKD30.58998645
57WEE10.53555307
58CDK10.51702212
59ERBB30.51607825
60CDK30.51092628
61OXSR10.50484490
62TAF10.46786480
63RPS6KA10.46496404
64CHEK20.46290624
65PRKAA20.45100278
66CHEK10.44117975
67WNK30.43856579
68TGFBR10.43278034
69LATS20.42583402
70WNK40.39548024
71PINK10.38065402
72CDK20.37615778
73PRKCG0.36021212
74VRK20.35673851
75KSR20.34729100
76GSK3B0.33766209
77VRK10.33241352
78RPS6KA20.32090664
79PRKG10.30942639
80ABL20.28028331
81FGFR10.27891562
82BLK0.27760939
83NME20.27652440
84BMPR20.27423470
85TSSK60.26331662
86NEK20.26311962
87MKNK10.24982581
88CDK90.24411886
89MAPK10.24306853
90ROCK10.23224517
91SGK10.22657344
92TRIM280.22626992
93NEK10.21886737
94PIM20.21165204
95PAK40.20897861
96MAPK140.20642596
97PRKACB0.20184029
98STK30.19311430
99MTOR0.18984152
100CAMK10.17397662

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.18483923
2Fatty acid biosynthesis_Homo sapiens_hsa000615.46019839
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.21667942
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.00199322
5RNA transport_Homo sapiens_hsa030132.93164380
6Olfactory transduction_Homo sapiens_hsa047402.53154560
7Mismatch repair_Homo sapiens_hsa034302.41505652
8Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.24879545
9Fanconi anemia pathway_Homo sapiens_hsa034602.12831802
10Vitamin B6 metabolism_Homo sapiens_hsa007502.10347542
11Selenocompound metabolism_Homo sapiens_hsa004502.04396238
12Fatty acid degradation_Homo sapiens_hsa000711.95755553
13Fatty acid metabolism_Homo sapiens_hsa012121.77033444
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74810148
15Proteasome_Homo sapiens_hsa030501.71436955
16Glutathione metabolism_Homo sapiens_hsa004801.49847500
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.46937234
18Butanoate metabolism_Homo sapiens_hsa006501.46498997
19DNA replication_Homo sapiens_hsa030301.45411482
20PPAR signaling pathway_Homo sapiens_hsa033201.42682832
21Antigen processing and presentation_Homo sapiens_hsa046121.41240056
22Base excision repair_Homo sapiens_hsa034101.41085790
23Taste transduction_Homo sapiens_hsa047421.36917481
24Cell cycle_Homo sapiens_hsa041101.34230019
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.33665038
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32005304
27RNA polymerase_Homo sapiens_hsa030201.29149416
28Basal transcription factors_Homo sapiens_hsa030221.29001629
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22878237
30Arginine and proline metabolism_Homo sapiens_hsa003301.20897154
31Lysosome_Homo sapiens_hsa041421.18911691
32Phenylalanine metabolism_Homo sapiens_hsa003601.16901358
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09912745
34Huntingtons disease_Homo sapiens_hsa050161.09795800
35Oocyte meiosis_Homo sapiens_hsa041141.02607294
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97111658
37Carbon metabolism_Homo sapiens_hsa012000.96860132
38Sulfur relay system_Homo sapiens_hsa041220.96812764
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95624423
40Biosynthesis of amino acids_Homo sapiens_hsa012300.94231557
41Dorso-ventral axis formation_Homo sapiens_hsa043200.92937624
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91027077
43Purine metabolism_Homo sapiens_hsa002300.84702735
44Propanoate metabolism_Homo sapiens_hsa006400.84523822
45Homologous recombination_Homo sapiens_hsa034400.84371526
46Pyruvate metabolism_Homo sapiens_hsa006200.82304118
47Type II diabetes mellitus_Homo sapiens_hsa049300.80573378
48Cardiac muscle contraction_Homo sapiens_hsa042600.80273166
49Galactose metabolism_Homo sapiens_hsa000520.76943799
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76641183
51Allograft rejection_Homo sapiens_hsa053300.74672151
52Influenza A_Homo sapiens_hsa051640.72507923
53Autoimmune thyroid disease_Homo sapiens_hsa053200.70639604
54Pyrimidine metabolism_Homo sapiens_hsa002400.70093820
55mRNA surveillance pathway_Homo sapiens_hsa030150.70082921
56Tyrosine metabolism_Homo sapiens_hsa003500.68440871
57Type I diabetes mellitus_Homo sapiens_hsa049400.67506653
58Other glycan degradation_Homo sapiens_hsa005110.63544964
59Nitrogen metabolism_Homo sapiens_hsa009100.62410755
60Fat digestion and absorption_Homo sapiens_hsa049750.60273957
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59124836
62Oxidative phosphorylation_Homo sapiens_hsa001900.58207356
63Graft-versus-host disease_Homo sapiens_hsa053320.57573000
64Nucleotide excision repair_Homo sapiens_hsa034200.54593209
65Retinol metabolism_Homo sapiens_hsa008300.54526496
66Non-homologous end-joining_Homo sapiens_hsa034500.53687607
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.52646683
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52021908
69Arginine biosynthesis_Homo sapiens_hsa002200.51395849
70Metabolic pathways_Homo sapiens_hsa011000.51363109
71Viral myocarditis_Homo sapiens_hsa054160.49943116
72RNA degradation_Homo sapiens_hsa030180.49156856
73One carbon pool by folate_Homo sapiens_hsa006700.49105260
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49062797
75Mineral absorption_Homo sapiens_hsa049780.47945193
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45533946
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44145696
78Adherens junction_Homo sapiens_hsa045200.43798565
79Collecting duct acid secretion_Homo sapiens_hsa049660.42625326
80Glycerolipid metabolism_Homo sapiens_hsa005610.41554597
81Endocytosis_Homo sapiens_hsa041440.39684054
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.39065362
83Fatty acid elongation_Homo sapiens_hsa000620.37727332
84Notch signaling pathway_Homo sapiens_hsa043300.37338981
85Spliceosome_Homo sapiens_hsa030400.36913149
86Phototransduction_Homo sapiens_hsa047440.36637117
87Synaptic vesicle cycle_Homo sapiens_hsa047210.34462299
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34419918
89Phagosome_Homo sapiens_hsa041450.30791760
90Legionellosis_Homo sapiens_hsa051340.29785250
91Protein digestion and absorption_Homo sapiens_hsa049740.27453375
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26947089
93Epstein-Barr virus infection_Homo sapiens_hsa051690.26821136
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25848803
95Tight junction_Homo sapiens_hsa045300.24650941
96Inositol phosphate metabolism_Homo sapiens_hsa005620.23606249
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22536461
98beta-Alanine metabolism_Homo sapiens_hsa004100.22428742
99Steroid biosynthesis_Homo sapiens_hsa001000.21985880
100Staphylococcus aureus infection_Homo sapiens_hsa051500.17612425

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