

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of gamma-delta T cell activation (GO:0046645) | 7.03124949 |
| 2 | regulation of gamma-delta T cell differentiation (GO:0045586) | 6.22812970 |
| 3 | negative T cell selection (GO:0043383) | 6.15259554 |
| 4 | positive thymic T cell selection (GO:0045059) | 6.08884670 |
| 5 | regulation of gamma-delta T cell activation (GO:0046643) | 5.81813727 |
| 6 | negative thymic T cell selection (GO:0045060) | 5.76286575 |
| 7 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.72865484 |
| 8 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.72865484 |
| 9 | positive T cell selection (GO:0043368) | 5.70939032 |
| 10 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.36496285 |
| 11 | negative regulation of cell killing (GO:0031342) | 5.36496285 |
| 12 | thymic T cell selection (GO:0045061) | 5.06262511 |
| 13 | leukocyte aggregation (GO:0070486) | 4.99054310 |
| 14 | T cell selection (GO:0045058) | 4.85616529 |
| 15 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 4.84127954 |
| 16 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.81296010 |
| 17 | interferon-gamma production (GO:0032609) | 4.41045689 |
| 18 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 4.39252404 |
| 19 | activated T cell proliferation (GO:0050798) | 4.19893758 |
| 20 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.14661606 |
| 21 | macrophage activation involved in immune response (GO:0002281) | 4.09552147 |
| 22 | T cell receptor signaling pathway (GO:0050852) | 4.09078272 |
| 23 | response to interleukin-15 (GO:0070672) | 4.07732925 |
| 24 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.06571197 |
| 25 | positive regulation of tolerance induction (GO:0002645) | 4.06387222 |
| 26 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.05871898 |
| 27 | tolerance induction (GO:0002507) | 3.93655726 |
| 28 | regulation of T cell tolerance induction (GO:0002664) | 3.86516653 |
| 29 | T cell migration (GO:0072678) | 3.81669726 |
| 30 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.67552217 |
| 31 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.61945910 |
| 32 | T cell costimulation (GO:0031295) | 3.61314164 |
| 33 | detection of other organism (GO:0098543) | 3.59698389 |
| 34 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.58475834 |
| 35 | detection of molecule of bacterial origin (GO:0032490) | 3.57206040 |
| 36 | response to peptidoglycan (GO:0032494) | 3.56616267 |
| 37 | lymphocyte costimulation (GO:0031294) | 3.53851235 |
| 38 | regulation of tolerance induction (GO:0002643) | 3.51112837 |
| 39 | response to type I interferon (GO:0034340) | 3.44163835 |
| 40 | type I interferon signaling pathway (GO:0060337) | 3.43454229 |
| 41 | cellular response to type I interferon (GO:0071357) | 3.43454229 |
| 42 | microglial cell activation (GO:0001774) | 3.42286509 |
| 43 | leukocyte cell-cell adhesion (GO:0007159) | 3.41147329 |
| 44 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 3.40409110 |
| 45 | cellular response to interleukin-15 (GO:0071350) | 3.36139685 |
| 46 | detection of bacterium (GO:0016045) | 3.29833157 |
| 47 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.27337462 |
| 48 | cellular extravasation (GO:0045123) | 3.26992249 |
| 49 | detection of external biotic stimulus (GO:0098581) | 3.23370721 |
| 50 | positive regulation of interleukin-2 production (GO:0032743) | 3.21173240 |
| 51 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.20250065 |
| 52 | regulation of regulatory T cell differentiation (GO:0045589) | 3.20022925 |
| 53 | positive regulation of B cell differentiation (GO:0045579) | 3.19311086 |
| 54 | neutrophil activation involved in immune response (GO:0002283) | 3.18729179 |
| 55 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.17474591 |
| 56 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.16347971 |
| 57 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.16347971 |
| 58 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.14386209 |
| 59 | regulation of B cell differentiation (GO:0045577) | 3.13620493 |
| 60 | natural killer cell differentiation (GO:0001779) | 3.13582491 |
| 61 | macrophage activation (GO:0042116) | 3.09985095 |
| 62 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 3.09903260 |
| 63 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.09899833 |
| 64 | positive regulation of humoral immune response (GO:0002922) | 3.09533410 |
| 65 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.05756426 |
| 66 | response to host immune response (GO:0052572) | 3.03866083 |
| 67 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.03866083 |
| 68 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.00383812 |
| 69 | modulation by symbiont of host defense response (GO:0052031) | 2.99081346 |
| 70 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 2.99081346 |
| 71 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 2.99081346 |
| 72 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 2.99081346 |
| 73 | modulation by symbiont of host immune response (GO:0052553) | 2.99081346 |
| 74 | positive regulation by symbiont of host defense response (GO:0052509) | 2.99081346 |
| 75 | detection of biotic stimulus (GO:0009595) | 2.99007780 |
| 76 | histone H3-K36 demethylation (GO:0070544) | 2.98453375 |
| 77 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.97704737 |
| 78 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.97704737 |
| 79 | V(D)J recombination (GO:0033151) | 2.97073991 |
| 80 | response to muramyl dipeptide (GO:0032495) | 2.96649418 |
| 81 | germinal center formation (GO:0002467) | 2.93559036 |
| 82 | regulation of extracellular matrix disassembly (GO:0010715) | 2.93401754 |
| 83 | myeloid cell activation involved in immune response (GO:0002275) | 2.92909818 |
| 84 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.92380696 |
| 85 | positive regulation of histone deacetylation (GO:0031065) | 2.90734921 |
| 86 | response to laminar fluid shear stress (GO:0034616) | 2.89042781 |
| 87 | B cell receptor signaling pathway (GO:0050853) | 2.88325636 |
| 88 | response to host (GO:0075136) | 2.87345020 |
| 89 | response to host defenses (GO:0052200) | 2.87345020 |
| 90 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.87345020 |
| 91 | defense response to protozoan (GO:0042832) | 2.87173590 |
| 92 | cellular response to ethanol (GO:0071361) | 2.86888905 |
| 93 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.86512407 |
| 94 | neutrophil activation (GO:0042119) | 2.85381779 |
| 95 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.84814663 |
| 96 | negative regulation of interleukin-12 production (GO:0032695) | 2.84512223 |
| 97 | T cell differentiation (GO:0030217) | 2.82648479 |
| 98 | natural killer cell activation (GO:0030101) | 2.82300782 |
| 99 | positive regulation of granulocyte differentiation (GO:0030854) | 2.81327972 |
| 100 | regulation of response to interferon-gamma (GO:0060330) | 2.81159666 |
| 101 | hepatocyte apoptotic process (GO:0097284) | 2.79008348 |
| 102 | regulation of T cell receptor signaling pathway (GO:0050856) | 2.77793685 |
| 103 | negative regulation of adaptive immune response (GO:0002820) | 2.75097081 |
| 104 | immunoglobulin mediated immune response (GO:0016064) | 2.74318115 |
| 105 | regulation of interferon-alpha production (GO:0032647) | 2.74201584 |
| 106 | positive regulation of isotype switching (GO:0045830) | 2.73552933 |
| 107 | antigen processing and presentation via MHC class Ib (GO:0002475) | 2.73154754 |
| 108 | T cell proliferation (GO:0042098) | 2.72716061 |
| 109 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.72231488 |
| 110 | positive regulation of interferon-alpha production (GO:0032727) | 2.72102563 |
| 111 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 2.70820759 |
| 112 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 2.70820759 |
| 113 | granulocyte activation (GO:0036230) | 2.70137904 |
| 114 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 2.69990721 |
| 115 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.68661084 |
| 116 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 2.67754541 |
| 117 | negative regulation of alpha-beta T cell activation (GO:0046636) | 2.66481207 |
| 118 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.65200616 |
| 119 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.64813350 |
| 120 | mast cell activation (GO:0045576) | 2.63299678 |
| 121 | neutrophil mediated immunity (GO:0002446) | 2.62802087 |
| 122 | myeloid leukocyte mediated immunity (GO:0002444) | 2.62311748 |
| 123 | lymphocyte homeostasis (GO:0002260) | 2.62207863 |
| 124 | response to protozoan (GO:0001562) | 2.62119361 |
| 125 | negative regulation of type 2 immune response (GO:0002829) | 2.60007133 |
| 126 | T cell activation (GO:0042110) | 2.59769700 |
| 127 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.58601318 |
| 128 | T cell homeostasis (GO:0043029) | 2.58172591 |
| 129 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.56279037 |
| 130 | alpha-beta T cell activation (GO:0046631) | 2.53022206 |
| 131 | positive regulation of B cell mediated immunity (GO:0002714) | 2.52240630 |
| 132 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 2.52240630 |
| 133 | radial glial cell differentiation (GO:0060019) | 2.50663203 |
| 134 | negative regulation of bone resorption (GO:0045779) | 2.46891301 |
| 135 | establishment of endothelial barrier (GO:0061028) | 2.46792514 |
| 136 | cytoplasmic mRNA processing body assembly (GO:0033962) | 2.46576951 |
| 137 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 2.43005205 |
| 138 | alpha-beta T cell differentiation (GO:0046632) | 2.39857240 |
| 139 | regulation of interleukin-2 production (GO:0032663) | 2.37796209 |
| 140 | positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360 | 2.37456286 |
| 141 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 2.35677083 |
| 142 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.35436592 |
| 143 | negative regulation of T cell mediated immunity (GO:0002710) | 2.34836570 |
| 144 | heterotypic cell-cell adhesion (GO:0034113) | 2.34179441 |
| 145 | mucosal-associated lymphoid tissue development (GO:0048537) | 2.32722035 |
| 146 | Peyers patch development (GO:0048541) | 2.32722035 |
| 147 | NIK/NF-kappaB signaling (GO:0038061) | 2.32399096 |
| 148 | leukocyte tethering or rolling (GO:0050901) | 2.31453980 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 5.89889500 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 4.92068299 |
| 3 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.92747948 |
| 4 | MYC_22102868_ChIP-Seq_BL_Human | 3.71437486 |
| 5 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.53858809 |
| 6 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.50976753 |
| 7 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.20817876 |
| 8 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.06089352 |
| 9 | * STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.97131244 |
| 10 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.95627226 |
| 11 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.86281361 |
| 12 | MYB_26560356_Chip-Seq_TH2_Human | 2.75316755 |
| 13 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.68878599 |
| 14 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.66873982 |
| 15 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.65727259 |
| 16 | MAF_26560356_Chip-Seq_TH1_Human | 2.64371289 |
| 17 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.62052747 |
| 18 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.61193336 |
| 19 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.52399543 |
| 20 | UTX_26944678_Chip-Seq_JUKART_Human | 2.51823733 |
| 21 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.38208224 |
| 22 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.35453304 |
| 23 | MYB_26560356_Chip-Seq_TH1_Human | 2.32060829 |
| 24 | TCF7_22412390_ChIP-Seq_EML_Mouse | 2.29147499 |
| 25 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.27578211 |
| 26 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.27299870 |
| 27 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.20555007 |
| 28 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.20359277 |
| 29 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.17764073 |
| 30 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.16381845 |
| 31 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.00959837 |
| 32 | * MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.97625250 |
| 33 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.96018482 |
| 34 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.93680399 |
| 35 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.89921494 |
| 36 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.86505364 |
| 37 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.81475200 |
| 38 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.79774522 |
| 39 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.76680961 |
| 40 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.74259556 |
| 41 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.71543997 |
| 42 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.71024951 |
| 43 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.70078753 |
| 44 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.67202248 |
| 45 | MAF_26560356_Chip-Seq_TH2_Human | 1.63143371 |
| 46 | SPI1_23127762_ChIP-Seq_K562_Human | 1.61391462 |
| 47 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.60656679 |
| 48 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.55711826 |
| 49 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.53868466 |
| 50 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.52468083 |
| 51 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.47115603 |
| 52 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.43065151 |
| 53 | * PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.36234551 |
| 54 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.32385743 |
| 55 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.32035598 |
| 56 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.28289798 |
| 57 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.26229179 |
| 58 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.26026551 |
| 59 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.25916878 |
| 60 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.21889883 |
| 61 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.19017223 |
| 62 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.17896661 |
| 63 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.17770911 |
| 64 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.17638471 |
| 65 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.17383232 |
| 66 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.17183456 |
| 67 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.16017710 |
| 68 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15071895 |
| 69 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.12948506 |
| 70 | GATA1_19941826_ChIP-Seq_K562_Human | 1.11830411 |
| 71 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.10018107 |
| 72 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.05390268 |
| 73 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.04815735 |
| 74 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.04435825 |
| 75 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.04294351 |
| 76 | GATA2_19941826_ChIP-Seq_K562_Human | 1.03999494 |
| 77 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.03649326 |
| 78 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.03581034 |
| 79 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.03113865 |
| 80 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.02216161 |
| 81 | * FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.00708595 |
| 82 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.99371677 |
| 83 | * FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.99195132 |
| 84 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.96660651 |
| 85 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.96469647 |
| 86 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.96301049 |
| 87 | * ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.94167235 |
| 88 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93641692 |
| 89 | GATA1_22025678_ChIP-Seq_K562_Human | 0.93572628 |
| 90 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.93192487 |
| 91 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.92742649 |
| 92 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.92679428 |
| 93 | GATA3_26560356_Chip-Seq_TH2_Human | 0.89089514 |
| 94 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.88543418 |
| 95 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.87723151 |
| 96 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.85773335 |
| 97 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.85751740 |
| 98 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.85306282 |
| 99 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.85204375 |
| 100 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.85180295 |
| 101 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.85015470 |
| 102 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.84686912 |
| 103 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.84027063 |
| 104 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.82508390 |
| 105 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.82001390 |
| 106 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.81865071 |
| 107 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.81854492 |
| 108 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.81214608 |
| 109 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.81055857 |
| 110 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.80233394 |
| 111 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.79517153 |
| 112 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.79277153 |
| 113 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.79008230 |
| 114 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.77376970 |
| 115 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.76965186 |
| 116 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.76078553 |
| 117 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.75669416 |
| 118 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.74917951 |
| 119 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.74892211 |
| 120 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 0.74552146 |
| 121 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.73635772 |
| 122 | KDM2B_26808549_Chip-Seq_K562_Human | 0.72684257 |
| 123 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.72236798 |
| 124 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.71523708 |
| 125 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.68791614 |
| 126 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.67753195 |
| 127 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.66956648 |
| 128 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.66660648 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 3.82995430 |
| 2 | MP0005671_abnormal_response_to | 3.37130792 |
| 3 | MP0003300_gastrointestinal_ulcer | 3.15768562 |
| 4 | MP0000685_abnormal_immune_system | 2.94487289 |
| 5 | MP0001800_abnormal_humoral_immune | 2.70542386 |
| 6 | MP0001835_abnormal_antigen_presentation | 2.65183591 |
| 7 | MP0006082_CNS_inflammation | 2.64974528 |
| 8 | MP0002166_altered_tumor_susceptibility | 2.48611545 |
| 9 | MP0002420_abnormal_adaptive_immunity | 2.35677075 |
| 10 | MP0002398_abnormal_bone_marrow | 2.35055314 |
| 11 | MP0002396_abnormal_hematopoietic_system | 2.34540229 |
| 12 | MP0001819_abnormal_immune_cell | 2.33561428 |
| 13 | MP0002723_abnormal_immune_serum | 2.31559034 |
| 14 | MP0002452_abnormal_antigen_presenting | 2.29493829 |
| 15 | MP0009785_altered_susceptibility_to | 2.26424158 |
| 16 | MP0005464_abnormal_platelet_physiology | 2.22609953 |
| 17 | MP0005387_immune_system_phenotype | 2.22041809 |
| 18 | MP0001790_abnormal_immune_system | 2.22041809 |
| 19 | MP0005000_abnormal_immune_tolerance | 2.21798332 |
| 20 | MP0003436_decreased_susceptibility_to | 2.19975223 |
| 21 | MP0000703_abnormal_thymus_morphology | 2.16792282 |
| 22 | MP0003303_peritoneal_inflammation | 2.14295347 |
| 23 | MP0004947_skin_inflammation | 2.10708139 |
| 24 | MP0005025_abnormal_response_to | 2.08770500 |
| 25 | MP0000716_abnormal_immune_system | 2.05708210 |
| 26 | MP0009278_abnormal_bone_marrow | 2.04220928 |
| 27 | MP0001873_stomach_inflammation | 2.01561759 |
| 28 | MP0010155_abnormal_intestine_physiology | 2.01156075 |
| 29 | MP0002009_preneoplasia | 1.99630671 |
| 30 | MP0002419_abnormal_innate_immunity | 1.98442449 |
| 31 | MP0002405_respiratory_system_inflammati | 1.94635137 |
| 32 | MP0002722_abnormal_immune_system | 1.93214095 |
| 33 | MP0002006_tumorigenesis | 1.91559418 |
| 34 | MP0000689_abnormal_spleen_morphology | 1.88596542 |
| 35 | MP0009333_abnormal_splenocyte_physiolog | 1.86984879 |
| 36 | MP0003191_abnormal_cellular_cholesterol | 1.75217523 |
| 37 | MP0002429_abnormal_blood_cell | 1.72143705 |
| 38 | MP0004808_abnormal_hematopoietic_stem | 1.71724223 |
| 39 | MP0003690_abnormal_glial_cell | 1.71599072 |
| 40 | MP0001845_abnormal_inflammatory_respons | 1.65914052 |
| 41 | MP0004883_abnormal_blood_vessel | 1.64746893 |
| 42 | MP0003724_increased_susceptibility_to | 1.60413056 |
| 43 | MP0008260_abnormal_autophagy | 1.54326615 |
| 44 | MP0005360_urolithiasis | 1.52329697 |
| 45 | MP0002933_joint_inflammation | 1.51635999 |
| 46 | MP0003866_abnormal_defecation | 1.45953430 |
| 47 | MP0005076_abnormal_cell_differentiation | 1.44311644 |
| 48 | MP0002148_abnormal_hypersensitivity_rea | 1.36539286 |
| 49 | MP0000858_altered_metastatic_potential | 1.34122846 |
| 50 | MP0008057_abnormal_DNA_replication | 1.30307821 |
| 51 | MP0005409_darkened_coat_color | 1.29603685 |
| 52 | MP0003183_abnormal_peptide_metabolism | 1.25914263 |
| 53 | MP0001533_abnormal_skeleton_physiology | 1.25044134 |
| 54 | MP0005365_abnormal_bile_salt | 1.20974133 |
| 55 | MP0003252_abnormal_bile_duct | 1.20924726 |
| 56 | MP0008469_abnormal_protein_level | 1.20227385 |
| 57 | MP0010352_gastrointestinal_tract_polyps | 1.19857042 |
| 58 | MP0005397_hematopoietic_system_phenotyp | 1.19720626 |
| 59 | MP0001545_abnormal_hematopoietic_system | 1.19720626 |
| 60 | MP0002138_abnormal_hepatobiliary_system | 1.17659186 |
| 61 | MP0000604_amyloidosis | 1.16517693 |
| 62 | MP0002139_abnormal_hepatobiliary_system | 1.15995543 |
| 63 | MP0001851_eye_inflammation | 1.15989174 |
| 64 | MP0005085_abnormal_gallbladder_physiolo | 1.14505676 |
| 65 | MP0005023_abnormal_wound_healing | 1.11602157 |
| 66 | MP0009840_abnormal_foam_cell | 1.11004461 |
| 67 | MP0000609_abnormal_liver_physiology | 1.10343176 |
| 68 | MP0003448_altered_tumor_morphology | 1.09637673 |
| 69 | MP0005310_abnormal_salivary_gland | 1.08210025 |
| 70 | MP0005164_abnormal_response_to | 1.07177657 |
| 71 | MP0000015_abnormal_ear_pigmentation | 1.06884677 |
| 72 | MP0002277_abnormal_respiratory_mucosa | 1.06623820 |
| 73 | MP0006054_spinal_hemorrhage | 1.02886022 |
| 74 | MP0000569_abnormal_digit_pigmentation | 1.01808685 |
| 75 | MP0003172_abnormal_lysosome_physiology | 1.01603689 |
| 76 | MP0000465_gastrointestinal_hemorrhage | 0.98067263 |
| 77 | MP0001663_abnormal_digestive_system | 0.97480530 |
| 78 | MP0000490_abnormal_crypts_of | 0.97372946 |
| 79 | MP0001853_heart_inflammation | 0.96748938 |
| 80 | MP0002998_abnormal_bone_remodeling | 0.94187388 |
| 81 | MP0008004_abnormal_stomach_pH | 0.93441668 |
| 82 | MP0003075_altered_response_to | 0.92991453 |
| 83 | MP0003828_pulmonary_edema | 0.92610623 |
| 84 | MP0008961_abnormal_basal_metabolism | 0.92353126 |
| 85 | MP0010234_abnormal_vibrissa_follicle | 0.91491804 |
| 86 | MP0003566_abnormal_cell_adhesion | 0.91158918 |
| 87 | MP0002019_abnormal_tumor_incidence | 0.90199795 |
| 88 | MP0002928_abnormal_bile_duct | 0.89871792 |
| 89 | MP0003453_abnormal_keratinocyte_physiol | 0.89448946 |
| 90 | MP0005174_abnormal_tail_pigmentation | 0.88170453 |
| 91 | MP0003656_abnormal_erythrocyte_physiolo | 0.86769453 |
| 92 | MP0001915_intracranial_hemorrhage | 0.82837111 |
| 93 | MP0010307_abnormal_tumor_latency | 0.82639806 |
| 94 | MP0004381_abnormal_hair_follicle | 0.82614043 |
| 95 | MP0005166_decreased_susceptibility_to | 0.82418736 |
| 96 | MP0005058_abnormal_lysosome_morphology | 0.81734184 |
| 97 | MP0009763_increased_sensitivity_to | 0.78748080 |
| 98 | MP0002132_abnormal_respiratory_system | 0.75687760 |
| 99 | MP0003091_abnormal_cell_migration | 0.75681847 |
| 100 | MP0005083_abnormal_biliary_tract | 0.75546857 |
| 101 | MP0000249_abnormal_blood_vessel | 0.75479298 |
| 102 | MP0000598_abnormal_liver_morphology | 0.74396899 |
| 103 | MP0004510_myositis | 0.73236686 |
| 104 | MP0000477_abnormal_intestine_morphology | 0.72773448 |
| 105 | MP0002136_abnormal_kidney_physiology | 0.72505385 |
| 106 | MP0000920_abnormal_myelination | 0.71932906 |
| 107 | MP0001986_abnormal_taste_sensitivity | 0.71868988 |
| 108 | MP0003045_fibrosis | 0.70992402 |
| 109 | MP0001666_abnormal_nutrient_absorption | 0.68714706 |
| 110 | MP0003077_abnormal_cell_cycle | 0.67525214 |
| 111 | MP0005451_abnormal_body_composition | 0.66328234 |
| 112 | MP0010678_abnormal_skin_adnexa | 0.66220577 |
| 113 | MP0005248_abnormal_Harderian_gland | 0.64659981 |
| 114 | MP0009765_abnormal_xenobiotic_induced | 0.64527128 |
| 115 | MP0009764_decreased_sensitivity_to | 0.63597705 |
| 116 | MP0002168_other_aberrant_phenotype | 0.63509309 |
| 117 | MP0000767_abnormal_smooth_muscle | 0.62976646 |
| 118 | MP0003795_abnormal_bone_structure | 0.62577839 |
| 119 | MP0005167_abnormal_blood-brain_barrier | 0.61349297 |
| 120 | MP0002088_abnormal_embryonic_growth/wei | 0.60839514 |
| 121 | MP0009115_abnormal_fat_cell | 0.60829694 |
| 122 | MP0005390_skeleton_phenotype | 0.60780058 |
| 123 | MP0004130_abnormal_muscle_cell | 0.60543786 |
| 124 | MP0003329_amyloid_beta_deposits | 0.59762129 |
| 125 | MP0000350_abnormal_cell_proliferation | 0.59558729 |
| 126 | MP0005381_digestive/alimentary_phenotyp | 0.58571950 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 5.80430744 |
| 2 | Abnormality of T cell number (HP:0011839) | 5.55681030 |
| 3 | Recurrent viral infections (HP:0004429) | 4.04371280 |
| 4 | Eczematoid dermatitis (HP:0000976) | 3.92590194 |
| 5 | Recurrent fungal infections (HP:0002841) | 3.78040052 |
| 6 | Abnormality of the fingertips (HP:0001211) | 3.77205422 |
| 7 | Severe combined immunodeficiency (HP:0004430) | 3.72794610 |
| 8 | Abnormality of T cells (HP:0002843) | 3.66482077 |
| 9 | Combined immunodeficiency (HP:0005387) | 3.65739447 |
| 10 | Keratoconjunctivitis sicca (HP:0001097) | 3.47778756 |
| 11 | Eosinophilia (HP:0001880) | 3.42435991 |
| 12 | Thyroiditis (HP:0100646) | 3.41601780 |
| 13 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.40881306 |
| 14 | IgM deficiency (HP:0002850) | 3.26179386 |
| 15 | Gastrointestinal infarctions (HP:0005244) | 3.19683221 |
| 16 | Keratoconjunctivitis (HP:0001096) | 3.17028658 |
| 17 | Autoimmune thrombocytopenia (HP:0001973) | 3.16559517 |
| 18 | B lymphocytopenia (HP:0010976) | 3.12358174 |
| 19 | Abnormality of B cell number (HP:0010975) | 3.12358174 |
| 20 | Panhypogammaglobulinemia (HP:0003139) | 3.12342196 |
| 21 | Recurrent abscess formation (HP:0002722) | 3.11803509 |
| 22 | Gingivitis (HP:0000230) | 3.11035658 |
| 23 | Pulmonary infiltrates (HP:0002113) | 3.07015550 |
| 24 | Stomatitis (HP:0010280) | 3.05355380 |
| 25 | Aortic aneurysm (HP:0004942) | 3.04997827 |
| 26 | Abnormality of eosinophils (HP:0001879) | 3.04827956 |
| 27 | Spontaneous hematomas (HP:0007420) | 3.02029261 |
| 28 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 3.00007782 |
| 29 | Chronic otitis media (HP:0000389) | 2.95885748 |
| 30 | Chronic diarrhea (HP:0002028) | 2.92382151 |
| 31 | Pustule (HP:0200039) | 2.91995305 |
| 32 | Recurrent bronchitis (HP:0002837) | 2.90077990 |
| 33 | Leukocytosis (HP:0001974) | 2.88755235 |
| 34 | Meningitis (HP:0001287) | 2.80561776 |
| 35 | Inflammation of the large intestine (HP:0002037) | 2.76408490 |
| 36 | Gastrointestinal inflammation (HP:0004386) | 2.76324571 |
| 37 | Recurrent bacterial skin infections (HP:0005406) | 2.75885084 |
| 38 | Granulocytopenia (HP:0001913) | 2.74897018 |
| 39 | Myositis (HP:0100614) | 2.73687650 |
| 40 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.72153332 |
| 41 | Colitis (HP:0002583) | 2.69861286 |
| 42 | Verrucae (HP:0200043) | 2.67461492 |
| 43 | Papilloma (HP:0012740) | 2.67461492 |
| 44 | Bicuspid aortic valve (HP:0001647) | 2.66452535 |
| 45 | Hematochezia (HP:0002573) | 2.66097457 |
| 46 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.63406334 |
| 47 | Recurrent cutaneous fungal infections (HP:0011370) | 2.63406334 |
| 48 | Nasal polyposis (HP:0100582) | 2.62268929 |
| 49 | Chest pain (HP:0100749) | 2.62063384 |
| 50 | Hypoplasia of the thymus (HP:0000778) | 2.59397773 |
| 51 | Joint swelling (HP:0001386) | 2.57967018 |
| 52 | Cellulitis (HP:0100658) | 2.55688555 |
| 53 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.52685150 |
| 54 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.51737398 |
| 55 | Lymphopenia (HP:0001888) | 2.51441104 |
| 56 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.51299379 |
| 57 | Recurrent skin infections (HP:0001581) | 2.48290119 |
| 58 | Abnormality of the nasal mucosa (HP:0000433) | 2.37977342 |
| 59 | Papilledema (HP:0001085) | 2.35930481 |
| 60 | Abnormality of the pleura (HP:0002103) | 2.35516619 |
| 61 | Arterial tortuosity (HP:0005116) | 2.34436879 |
| 62 | Autoimmune hemolytic anemia (HP:0001890) | 2.32417402 |
| 63 | Vasculitis (HP:0002633) | 2.31756267 |
| 64 | IgG deficiency (HP:0004315) | 2.30514405 |
| 65 | Mediastinal lymphadenopathy (HP:0100721) | 2.26946481 |
| 66 | Increased IgM level (HP:0003496) | 2.26931137 |
| 67 | Agammaglobulinemia (HP:0004432) | 2.23742305 |
| 68 | Stomach cancer (HP:0012126) | 2.23057937 |
| 69 | Pulmonary embolism (HP:0002204) | 2.19078489 |
| 70 | Absent frontal sinuses (HP:0002688) | 2.18817566 |
| 71 | Gangrene (HP:0100758) | 2.17996116 |
| 72 | Glomerulonephritis (HP:0000099) | 2.17532845 |
| 73 | Cerebral aneurysm (HP:0004944) | 2.17195629 |
| 74 | Subacute progressive viral hepatitis (HP:0006572) | 2.13104881 |
| 75 | Periodontitis (HP:0000704) | 2.10673817 |
| 76 | Abnormality of T cell physiology (HP:0011840) | 2.08821756 |
| 77 | Obstructive lung disease (HP:0006536) | 2.07743112 |
| 78 | Chronic obstructive pulmonary disease (HP:0006510) | 2.07743112 |
| 79 | Arterial thrombosis (HP:0004420) | 2.04570956 |
| 80 | Abnormality of macrophages (HP:0004311) | 2.03575529 |
| 81 | Abnormality of the intervertebral disk (HP:0005108) | 2.03506903 |
| 82 | Abnormal platelet volume (HP:0011876) | 2.03281591 |
| 83 | Disproportionate tall stature (HP:0001519) | 2.02504623 |
| 84 | Persistence of primary teeth (HP:0006335) | 2.02482150 |
| 85 | Anorexia (HP:0002039) | 2.02394488 |
| 86 | Epistaxis (HP:0000421) | 2.01884701 |
| 87 | Systemic lupus erythematosus (HP:0002725) | 2.01159883 |
| 88 | Gingival bleeding (HP:0000225) | 2.00601537 |
| 89 | Slow saccadic eye movements (HP:0000514) | 2.00121471 |
| 90 | Deep venous thrombosis (HP:0002625) | 1.97658508 |
| 91 | Abnormality of the endocardium (HP:0004306) | 1.97649523 |
| 92 | Hemoptysis (HP:0002105) | 1.97045369 |
| 93 | Complement deficiency (HP:0004431) | 1.96281759 |
| 94 | Bronchitis (HP:0012387) | 1.95566997 |
| 95 | Prolonged bleeding time (HP:0003010) | 1.95527639 |
| 96 | Conjunctival telangiectasia (HP:0000524) | 1.95425538 |
| 97 | Hemiplegia (HP:0002301) | 1.93361997 |
| 98 | Vascular tortuosity (HP:0004948) | 1.92969018 |
| 99 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.92725660 |
| 100 | Increased CSF protein (HP:0002922) | 1.92391911 |
| 101 | Optic neuritis (HP:0100653) | 1.92223267 |
| 102 | Retrobulbar optic neuritis (HP:0100654) | 1.92223267 |
| 103 | Esophageal varix (HP:0002040) | 1.91636031 |
| 104 | Ureteral stenosis (HP:0000071) | 1.90804889 |
| 105 | Increased cerebral lipofuscin (HP:0011813) | 1.89942059 |
| 106 | Urticaria (HP:0001025) | 1.89338391 |
| 107 | Orchitis (HP:0100796) | 1.87436758 |
| 108 | Abnormal foot bone ossification (HP:0010675) | 1.85821272 |
| 109 | Ureteral obstruction (HP:0006000) | 1.85809318 |
| 110 | Lymphoma (HP:0002665) | 1.85174820 |
| 111 | Increased density of long bones (HP:0006392) | 1.85005935 |
| 112 | Alveolar cell carcinoma (HP:0006519) | 1.83986452 |
| 113 | Osteomyelitis (HP:0002754) | 1.83755185 |
| 114 | Amyloidosis (HP:0011034) | 1.83059999 |
| 115 | Bronchiectasis (HP:0002110) | 1.82759741 |
| 116 | Increased IgE level (HP:0003212) | 1.82689164 |
| 117 | Hypergammaglobulinemia (HP:0010702) | 1.82656363 |
| 118 | Cutis marmorata (HP:0000965) | 1.81499163 |
| 119 | IgA deficiency (HP:0002720) | 1.80879591 |
| 120 | Impaired platelet aggregation (HP:0003540) | 1.80140375 |
| 121 | Abnormal platelet function (HP:0011869) | 1.80140375 |
| 122 | Episodic fever (HP:0001954) | 1.78762851 |
| 123 | Thrombophlebitis (HP:0004418) | 1.78549226 |
| 124 | Vertigo (HP:0002321) | 1.78528047 |
| 125 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.78338958 |
| 126 | Segmental peripheral demyelination/remyelination (HP:0003481) | 1.77834714 |
| 127 | Acne (HP:0001061) | 1.75494156 |
| 128 | Glomerulopathy (HP:0100820) | 1.75011562 |
| 129 | Encephalitis (HP:0002383) | 1.74805927 |
| 130 | Striae distensae (HP:0001065) | 1.74177740 |
| 131 | Basal cell carcinoma (HP:0002671) | 1.73882620 |
| 132 | Spondylolisthesis (HP:0003302) | 1.71980999 |
| 133 | Increased mean platelet volume (HP:0011877) | 1.71560609 |
| 134 | Myocardial infarction (HP:0001658) | 1.71491562 |
| 135 | Recurrent sinusitis (HP:0011108) | 1.70468053 |
| 136 | Interstitial pulmonary disease (HP:0006530) | 1.70389457 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 4.37727511 |
| 2 | TXK | 3.62088325 |
| 3 | MAP3K10 | 3.34376450 |
| 4 | STK10 | 3.05567306 |
| 5 | RIPK4 | 3.01512495 |
| 6 | EEF2K | 2.88812001 |
| 7 | PRPF4B | 2.70473164 |
| 8 | ITK | 2.70409102 |
| 9 | TGFBR2 | 2.65550909 |
| 10 | FGFR4 | 2.50179112 |
| 11 | PKN2 | 2.41593584 |
| 12 | FGFR3 | 2.31352749 |
| 13 | TYK2 | 2.26750300 |
| 14 | ZAP70 | 2.13746517 |
| 15 | JAK3 | 2.11751090 |
| 16 | EPHB1 | 1.81831992 |
| 17 | GRK6 | 1.81817116 |
| 18 | MAP3K14 | 1.78476610 |
| 19 | CDK12 | 1.76206553 |
| 20 | JAK1 | 1.73609318 |
| 21 | IKBKE | 1.71520434 |
| 22 | TRIB3 | 1.59568571 |
| 23 | TNK2 | 1.59361931 |
| 24 | SIK3 | 1.55088214 |
| 25 | CSK | 1.54777586 |
| 26 | SIK1 | 1.47163571 |
| 27 | IRAK1 | 1.40564611 |
| 28 | TBK1 | 1.40453553 |
| 29 | NLK | 1.39289240 |
| 30 | CLK1 | 1.38742135 |
| 31 | BTK | 1.38542244 |
| 32 | LCK | 1.37770040 |
| 33 | MARK3 | 1.35532878 |
| 34 | PTK6 | 1.35346270 |
| 35 | MAP3K3 | 1.30147970 |
| 36 | CSF1R | 1.27529614 |
| 37 | YES1 | 1.26645839 |
| 38 | LRRK2 | 1.25399053 |
| 39 | MST4 | 1.24421822 |
| 40 | ERN1 | 1.23470311 |
| 41 | CAMKK2 | 1.22307642 |
| 42 | FGR | 1.20428911 |
| 43 | HCK | 1.12553147 |
| 44 | TAOK1 | 1.08481915 |
| 45 | MELK | 1.08418977 |
| 46 | KDR | 1.06563215 |
| 47 | SGK2 | 1.05409312 |
| 48 | IRAK4 | 1.04488393 |
| 49 | EPHA3 | 1.03650283 |
| 50 | MAP3K7 | 1.02447944 |
| 51 | SYK | 1.02062174 |
| 52 | MARK2 | 1.01331184 |
| 53 | STK4 | 1.00488040 |
| 54 | JAK2 | 0.97899167 |
| 55 | CAMKK1 | 0.97646385 |
| 56 | SIK2 | 0.93062574 |
| 57 | CDK4 | 0.91448373 |
| 58 | CDC42BPA | 0.91283173 |
| 59 | PRKCQ | 0.89970698 |
| 60 | MAP3K1 | 0.89421747 |
| 61 | CHUK | 0.88352027 |
| 62 | GRK7 | 0.88138494 |
| 63 | BMPR2 | 0.86597886 |
| 64 | CDK6 | 0.85703715 |
| 65 | IRAK2 | 0.85678467 |
| 66 | FGFR2 | 0.85632087 |
| 67 | PIM1 | 0.84584125 |
| 68 | RPS6KA4 | 0.84329791 |
| 69 | TEC | 0.82932081 |
| 70 | RPS6KB2 | 0.81860873 |
| 71 | BLK | 0.81402069 |
| 72 | TESK2 | 0.80422334 |
| 73 | NEK2 | 0.79813184 |
| 74 | BRD4 | 0.75516834 |
| 75 | RIPK1 | 0.74025169 |
| 76 | NEK6 | 0.73373077 |
| 77 | CAMK1D | 0.72808323 |
| 78 | MAP3K13 | 0.72640368 |
| 79 | MAP2K3 | 0.72478933 |
| 80 | PRKCH | 0.71964752 |
| 81 | PDGFRB | 0.70683918 |
| 82 | FLT3 | 0.69328228 |
| 83 | IKBKB | 0.68607794 |
| 84 | MAPK7 | 0.66276395 |
| 85 | PAK4 | 0.65088447 |
| 86 | KSR2 | 0.63485940 |
| 87 | RET | 0.63381051 |
| 88 | LYN | 0.62743004 |
| 89 | NEK9 | 0.62608193 |
| 90 | MAPK11 | 0.62362599 |
| 91 | PASK | 0.60966861 |
| 92 | MAP3K8 | 0.60094592 |
| 93 | DMPK | 0.59014045 |
| 94 | SGK494 | 0.58642365 |
| 95 | SGK223 | 0.58642365 |
| 96 | HIPK2 | 0.58320432 |
| 97 | FGFR1 | 0.56795143 |
| 98 | SGK3 | 0.54383011 |
| 99 | MAP3K2 | 0.52958636 |
| 100 | DYRK1B | 0.52601656 |
| 101 | TTN | 0.52415084 |
| 102 | TRPM7 | 0.51506422 |
| 103 | MTOR | 0.48466359 |
| 104 | SMG1 | 0.48450706 |
| 105 | CAMK1G | 0.48142715 |
| 106 | PDK1 | 0.47226159 |
| 107 | WNK1 | 0.46956212 |
| 108 | MAPK15 | 0.44284072 |
| 109 | ALK | 0.43456945 |
| 110 | STK38 | 0.43148874 |
| 111 | STK11 | 0.43087577 |
| 112 | PDPK1 | 0.42801852 |
| 113 | MAPKAPK2 | 0.42281970 |
| 114 | MATK | 0.41852253 |
| 115 | FES | 0.40671174 |
| 116 | KSR1 | 0.39980985 |
| 117 | TAOK3 | 0.39520322 |
| 118 | MAP2K6 | 0.39441350 |
| 119 | STK3 | 0.39421401 |
| 120 | TGFBR1 | 0.38754370 |
| 121 | EGFR | 0.38332796 |
| 122 | MAPK12 | 0.38035671 |
| 123 | CDK9 | 0.37474123 |
| 124 | KIT | 0.36821218 |
| 125 | RPS6KC1 | 0.36698621 |
| 126 | RPS6KL1 | 0.36698621 |
| 127 | TSSK6 | 0.36567759 |
| 128 | IGF1R | 0.35371829 |
| 129 | MAPK4 | 0.34017337 |
| 130 | FYN | 0.33876863 |
| 131 | INSR | 0.33768875 |
| 132 | TYRO3 | 0.33025501 |
| 133 | NUAK1 | 0.30764883 |
| 134 | MAPKAPK3 | 0.30616665 |
| 135 | ERBB2 | 0.30274667 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.93929488 |
| 2 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.87265733 |
| 3 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.49808050 |
| 4 | Leishmaniasis_Homo sapiens_hsa05140 | 2.29627220 |
| 5 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.24373258 |
| 6 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.22066035 |
| 7 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.19458895 |
| 8 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.17702185 |
| 9 | Measles_Homo sapiens_hsa05162 | 2.17445839 |
| 10 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.06091398 |
| 11 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.99355010 |
| 12 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.77353251 |
| 13 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.74297913 |
| 14 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.73404193 |
| 15 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.66149532 |
| 16 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.65725953 |
| 17 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.65190158 |
| 18 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.60458965 |
| 19 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.53358045 |
| 20 | Viral myocarditis_Homo sapiens_hsa05416 | 1.48614552 |
| 21 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.43264210 |
| 22 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.42790508 |
| 23 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.41016047 |
| 24 | Hepatitis B_Homo sapiens_hsa05161 | 1.34619782 |
| 25 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.34134391 |
| 26 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.30514731 |
| 27 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.29189801 |
| 28 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.26425622 |
| 29 | Colorectal cancer_Homo sapiens_hsa05210 | 1.24602747 |
| 30 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.22486042 |
| 31 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.20358582 |
| 32 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.19444050 |
| 33 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.18988175 |
| 34 | Influenza A_Homo sapiens_hsa05164 | 1.17659569 |
| 35 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.16850455 |
| 36 | Legionellosis_Homo sapiens_hsa05134 | 1.16460263 |
| 37 | Lysine degradation_Homo sapiens_hsa00310 | 1.16271405 |
| 38 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.13893020 |
| 39 | Apoptosis_Homo sapiens_hsa04210 | 1.13586567 |
| 40 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.12808907 |
| 41 | HTLV-I infection_Homo sapiens_hsa05166 | 1.10947619 |
| 42 | Allograft rejection_Homo sapiens_hsa05330 | 1.10869250 |
| 43 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.08018192 |
| 44 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.05654267 |
| 45 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.98243906 |
| 46 | Hepatitis C_Homo sapiens_hsa05160 | 0.96757002 |
| 47 | Other glycan degradation_Homo sapiens_hsa00511 | 0.96687971 |
| 48 | Platelet activation_Homo sapiens_hsa04611 | 0.96100096 |
| 49 | Pertussis_Homo sapiens_hsa05133 | 0.95900567 |
| 50 | Shigellosis_Homo sapiens_hsa05131 | 0.95441120 |
| 51 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.94842562 |
| 52 | Asthma_Homo sapiens_hsa05310 | 0.94412371 |
| 53 | Adherens junction_Homo sapiens_hsa04520 | 0.93673800 |
| 54 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.93467628 |
| 55 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.89399367 |
| 56 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.89013140 |
| 57 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.88365855 |
| 58 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.88111467 |
| 59 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.85544834 |
| 60 | Endometrial cancer_Homo sapiens_hsa05213 | 0.85452380 |
| 61 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.85414705 |
| 62 | Insulin resistance_Homo sapiens_hsa04931 | 0.85334652 |
| 63 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.84581230 |
| 64 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.84318481 |
| 65 | Malaria_Homo sapiens_hsa05144 | 0.82825715 |
| 66 | ABC transporters_Homo sapiens_hsa02010 | 0.82539324 |
| 67 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.81988955 |
| 68 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.80729309 |
| 69 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.80216707 |
| 70 | Prostate cancer_Homo sapiens_hsa05215 | 0.79902637 |
| 71 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.78981451 |
| 72 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.78667636 |
| 73 | Tuberculosis_Homo sapiens_hsa05152 | 0.77643102 |
| 74 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.75242908 |
| 75 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.72456287 |
| 76 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.70914130 |
| 77 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.69963403 |
| 78 | Thyroid cancer_Homo sapiens_hsa05216 | 0.69345712 |
| 79 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.68629726 |
| 80 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.68468388 |
| 81 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.68063717 |
| 82 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.67304877 |
| 83 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.67121501 |
| 84 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.65351773 |
| 85 | Phagosome_Homo sapiens_hsa04145 | 0.65190041 |
| 86 | Salmonella infection_Homo sapiens_hsa05132 | 0.64602097 |
| 87 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.64366953 |
| 88 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.63988156 |
| 89 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.63813587 |
| 90 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.61620585 |
| 91 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.60759130 |
| 92 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.60474258 |
| 93 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.60156396 |
| 94 | Amoebiasis_Homo sapiens_hsa05146 | 0.56241207 |
| 95 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.55902059 |
| 96 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.54545462 |
| 97 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.54463743 |
| 98 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.54158389 |
| 99 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.52139106 |
| 100 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.50772211 |
| 101 | Glioma_Homo sapiens_hsa05214 | 0.50251638 |
| 102 | Long-term potentiation_Homo sapiens_hsa04720 | 0.49869355 |
| 103 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.49410514 |
| 104 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.49336696 |
| 105 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.49326827 |
| 106 | Prion diseases_Homo sapiens_hsa05020 | 0.47735474 |
| 107 | Pathways in cancer_Homo sapiens_hsa05200 | 0.47556060 |
| 108 | Endocytosis_Homo sapiens_hsa04144 | 0.47421579 |
| 109 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.46413269 |
| 110 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.46186680 |
| 111 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.41465455 |
| 112 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.41323383 |
| 113 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.41124943 |
| 114 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.41117366 |
| 115 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.39243507 |
| 116 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.38372262 |
| 117 | Focal adhesion_Homo sapiens_hsa04510 | 0.38267085 |
| 118 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.37314472 |
| 119 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.37167745 |
| 120 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.36375457 |
| 121 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.35529786 |
| 122 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.34105906 |
| 123 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.33523826 |
| 124 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.33380530 |
| 125 | Lysosome_Homo sapiens_hsa04142 | 0.28204249 |

