SPATA16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a testis-specific protein that belongs to the tetratricopeptide repeat-like superfamily. The encoded protein localizes to the Golgi apparatus and may play a role in spermatogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.94291936
2motile cilium assembly (GO:0044458)9.33502631
3reproduction (GO:0000003)9.26382958
4spermatid development (GO:0007286)9.09666863
5male meiosis (GO:0007140)8.97927695
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.73838321
7cilium movement (GO:0003341)8.50826384
8synaptonemal complex organization (GO:0070193)8.28958355
9synaptonemal complex assembly (GO:0007130)8.04159465
10regulation of cilium movement (GO:0003352)7.54136296
11single fertilization (GO:0007338)7.51143071
12DNA methylation involved in gamete generation (GO:0043046)6.54501595
13fertilization (GO:0009566)6.49425927
14sperm capacitation (GO:0048240)6.45661143
15negative regulation of inclusion body assembly (GO:0090084)6.01487832
16* spermatogenesis (GO:0007283)5.98452571
17* male gamete generation (GO:0048232)5.96374418
18male meiosis I (GO:0007141)5.77162054
19chromosome organization involved in meiosis (GO:0070192)5.68831057
20protein targeting to Golgi (GO:0000042)5.56559585
21establishment of protein localization to Golgi (GO:0072600)5.53270619
22microtubule depolymerization (GO:0007019)5.52073178
23* gamete generation (GO:0007276)5.47933845
24ventricular system development (GO:0021591)5.34497251
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.32000311
26germ cell development (GO:0007281)5.25613375
27glutathione biosynthetic process (GO:0006750)5.23687105
28seminiferous tubule development (GO:0072520)5.18771966
29organic cation transport (GO:0015695)5.11272626
30meiotic nuclear division (GO:0007126)5.09073236
31retrograde transport, vesicle recycling within Golgi (GO:0000301)5.04265147
32one-carbon compound transport (GO:0019755)4.96259674
33regulation of inclusion body assembly (GO:0090083)4.91923986
34cell recognition (GO:0008037)4.91842603
35nonribosomal peptide biosynthetic process (GO:0019184)4.78877310
36calcium ion-dependent exocytosis (GO:0017156)4.75347616
37meiosis I (GO:0007127)4.66495340
38microtubule severing (GO:0051013)4.55390457
39regulation of establishment of cell polarity (GO:2000114)4.51192375
40regulation of microtubule-based movement (GO:0060632)4.47285912
41monoubiquitinated protein deubiquitination (GO:0035520)4.45013615
42histone exchange (GO:0043486)4.42288083
43protein localization to cilium (GO:0061512)4.40780450
44meiotic cell cycle (GO:0051321)4.33650749
45* multicellular organismal reproductive process (GO:0048609)4.29415257
46genitalia morphogenesis (GO:0035112)4.15641814
47left/right pattern formation (GO:0060972)4.04685073
48regulation of histone H3-K9 methylation (GO:0051570)4.02355372
49chaperone-mediated protein complex assembly (GO:0051131)4.01511318
50sex differentiation (GO:0007548)4.00783053
51regulation of interleukin-13 production (GO:0032656)3.98436048
52glycerol ether metabolic process (GO:0006662)3.94963855
53regulation of female gonad development (GO:2000194)3.94224093
54DNA double-strand break processing (GO:0000729)3.81139484
55protein localization to Golgi apparatus (GO:0034067)3.80178398
56gene silencing by RNA (GO:0031047)3.73971730
57centrosome duplication (GO:0051298)3.73573836
58intraciliary transport (GO:0042073)3.71154200
59rRNA methylation (GO:0031167)3.69994932
60lactate metabolic process (GO:0006089)3.69004072
61phosphatidylethanolamine biosynthetic process (GO:0006646)3.67469302
62regulation of establishment or maintenance of cell polarity (GO:0032878)3.66811372
63ether metabolic process (GO:0018904)3.64499165
64female gamete generation (GO:0007292)3.60343849
65spermatid nucleus differentiation (GO:0007289)3.59895073
66sleep (GO:0030431)3.59174318
67single strand break repair (GO:0000012)3.55273015
68positive regulation of endothelial cell differentiation (GO:0045603)3.53473974
69synapsis (GO:0007129)3.52077174
70regulation of memory T cell differentiation (GO:0043380)3.52049877
71leukotriene biosynthetic process (GO:0019370)3.51239642
72* multicellular organismal development (GO:0007275)3.50174405
73somite rostral/caudal axis specification (GO:0032525)3.48053500
74histone mRNA catabolic process (GO:0071044)3.47444890
75peptide biosynthetic process (GO:0043043)3.45873788
76response to pheromone (GO:0019236)3.45352901
77protein polyglutamylation (GO:0018095)3.44558355
78alditol metabolic process (GO:0019400)3.43663695
79cellular ketone body metabolic process (GO:0046950)3.37487842
80GTP biosynthetic process (GO:0006183)3.37306915
81regulation of Rab GTPase activity (GO:0032313)3.37016854
82positive regulation of Rab GTPase activity (GO:0032851)3.37016854
83negative regulation of organelle assembly (GO:1902116)3.36978068
84polyol catabolic process (GO:0046174)3.34292105
85phosphatidylethanolamine metabolic process (GO:0046337)3.32558989
86sequestering of actin monomers (GO:0042989)3.32188794
87chromosome condensation (GO:0030261)3.31903382
88axoneme assembly (GO:0035082)3.31379727
89protein K11-linked deubiquitination (GO:0035871)3.29904083
90meiotic cell cycle process (GO:1903046)3.29624667
91nucleoside diphosphate phosphorylation (GO:0006165)3.29394603
92rRNA modification (GO:0000154)3.28457889
93microtubule-based movement (GO:0007018)3.27882301
94polyamine biosynthetic process (GO:0006596)3.22445397
95phospholipid homeostasis (GO:0055091)3.20158877
96DNA packaging (GO:0006323)3.19371149
97NAD biosynthetic process (GO:0009435)3.17007617
98carnitine transport (GO:0015879)3.16993877
99amino-acid betaine transport (GO:0015838)3.16993877
100regulation of protein polyubiquitination (GO:1902914)3.15856392
101carnitine transmembrane transport (GO:1902603)3.14453974
102regulation of centriole replication (GO:0046599)3.08373426
103glycerol metabolic process (GO:0006071)3.06318905
104regulation of spindle checkpoint (GO:0090231)3.04347573
105negative regulation of Rho protein signal transduction (GO:0035024)3.03471177
106cilium organization (GO:0044782)3.03053379
107UTP biosynthetic process (GO:0006228)3.01784335
108mismatch repair (GO:0006298)3.01781603
109mitotic sister chromatid cohesion (GO:0007064)3.01059790
110cilium morphogenesis (GO:0060271)2.98703554
111polyol transport (GO:0015791)2.98303868
112oogenesis (GO:0048477)2.97812466
113intra-Golgi vesicle-mediated transport (GO:0006891)2.95949630
114regulation of mesoderm development (GO:2000380)2.95752854
115tryptophan metabolic process (GO:0006568)2.93767389
116ketone body metabolic process (GO:1902224)2.92780748
117cellular component assembly involved in morphogenesis (GO:0010927)2.92182692
118CENP-A containing nucleosome assembly (GO:0034080)2.90299233
119indolalkylamine metabolic process (GO:0006586)2.88727166
120regulation of MHC class I biosynthetic process (GO:0045343)2.88350386
121cilium assembly (GO:0042384)2.87496336
122glycolytic process (GO:0006096)2.87411109
123regulation of steroid hormone secretion (GO:2000831)2.85464232
124cellular biogenic amine biosynthetic process (GO:0042401)2.83090356
125nuclear pore complex assembly (GO:0051292)2.82134971
126protein refolding (GO:0042026)2.82096230
127oocyte development (GO:0048599)2.81671739
128regulation of interleukin-5 production (GO:0032674)2.81638209
129microtubule polymerization or depolymerization (GO:0031109)2.81077786
130regulation of meiosis I (GO:0060631)2.78897721
131UTP metabolic process (GO:0046051)2.75549038
132negative regulation of DNA repair (GO:0045738)2.74723846
133centriole assembly (GO:0098534)2.67535367
134gene silencing (GO:0016458)2.63463541
135centriole replication (GO:0007099)2.56480878
136regulation of chromatin binding (GO:0035561)2.52044682
137nucleus organization (GO:0006997)2.50929899
138fusion of sperm to egg plasma membrane (GO:0007342)14.2966925
139cilium or flagellum-dependent cell motility (GO:0001539)13.6206109
140acrosome assembly (GO:0001675)12.6491416
141sperm motility (GO:0030317)12.3780874
142sperm-egg recognition (GO:0035036)11.3701292
143multicellular organism reproduction (GO:0032504)11.3203803
144plasma membrane fusion (GO:0045026)10.8955165
145axonemal dynein complex assembly (GO:0070286)10.6942620
146binding of sperm to zona pellucida (GO:0007339)10.6135376
147cell wall macromolecule metabolic process (GO:0044036)10.4562948
148cell wall macromolecule catabolic process (GO:0016998)10.4562948
149acrosome reaction (GO:0007340)10.2995083
150cell-cell recognition (GO:0009988)10.1726462
151piRNA metabolic process (GO:0034587)10.1519668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57968264
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.02398944
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.55806057
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.62684551
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.34607447
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.29235391
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.99138906
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.88635994
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.64694334
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.61795065
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48852041
12ZNF274_21170338_ChIP-Seq_K562_Hela2.46427792
13FUS_26573619_Chip-Seq_HEK293_Human2.17330424
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16408642
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14189970
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.12895125
17UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.04937216
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.01980491
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.1923162
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98484869
21NANOG_20526341_ChIP-Seq_ESCs_Human1.91749155
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.91281612
23P300_19829295_ChIP-Seq_ESCs_Human1.86322114
24* GBX2_23144817_ChIP-Seq_PC3_Human1.84623567
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80843194
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.78456622
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.77880284
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.76774731
29ER_23166858_ChIP-Seq_MCF-7_Human1.75782982
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.75177745
31* BCAT_22108803_ChIP-Seq_LS180_Human1.73171170
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68518660
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.67992306
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65749943
35VDR_22108803_ChIP-Seq_LS180_Human1.64273262
36* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.62359961
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.60084462
38STAT1_17558387_ChIP-Seq_HELA_Human1.59876001
39AR_25329375_ChIP-Seq_VCAP_Human1.55541921
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.53765605
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53352631
42GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52567862
43TP53_18474530_ChIP-ChIP_U2OS_Human1.50894112
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.49320826
45OCT1_27270436_Chip-Seq_PROSTATE_Human1.49058817
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.48999977
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.48742780
48IGF1R_20145208_ChIP-Seq_DFB_Human1.46457915
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44782159
50FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42937117
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41418428
52DROSHA_22980978_ChIP-Seq_HELA_Human1.40305796
53ERA_21632823_ChIP-Seq_H3396_Human1.39356245
54VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.38221359
55TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.37092016
56* TAL1_26923725_Chip-Seq_HPCs_Mouse1.36998227
57SMAD4_21741376_ChIP-Seq_HESCs_Human1.36479602
58SMAD4_21799915_ChIP-Seq_A2780_Human1.36123857
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35549066
60TBL1_22424771_ChIP-Seq_293T_Human1.34786630
61* KDM2B_26808549_Chip-Seq_REH_Human1.32761364
62MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31790326
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31743059
64CBP_20019798_ChIP-Seq_JUKART_Human1.31743059
65GATA3_21867929_ChIP-Seq_CD8_Mouse1.31130578
66SOX2_19829295_ChIP-Seq_ESCs_Human1.31056002
67NANOG_19829295_ChIP-Seq_ESCs_Human1.31056002
68OCT4_20526341_ChIP-Seq_ESCs_Human1.29908008
69IRF1_19129219_ChIP-ChIP_H3396_Human1.29702255
70* RUNX2_22187159_ChIP-Seq_PCA_Human1.29290933
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.29270826
72* STAT3_23295773_ChIP-Seq_U87_Human1.29268317
73RAC3_21632823_ChIP-Seq_H3396_Human1.28602205
74* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.26972747
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26852719
76MYC_19829295_ChIP-Seq_ESCs_Human1.25449142
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23991579
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.23773355
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23694141
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22602589
81* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22496076
82REST_21632747_ChIP-Seq_MESCs_Mouse1.22110008
83FOXH1_21741376_ChIP-Seq_EPCs_Human1.22010831
84* TCF4_22108803_ChIP-Seq_LS180_Human1.19863670
85LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.19296956
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.17682520
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17682520
88* CDX2_22108803_ChIP-Seq_LS180_Human1.17437982
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.17083277
90TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.16672856
91GATA3_21867929_ChIP-Seq_TH1_Mouse1.15200052
92NFYB_21822215_ChIP-Seq_K562_Human1.14484867
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.13921162
94SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13766256
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13495906
96HNFA_21074721_ChIP-Seq_CACO-2_Human1.13486600
97ETV1_20927104_ChIP-Seq_GIST48_Human1.13448991
98P53_21459846_ChIP-Seq_SAOS-2_Human1.12891075
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11844370
100GATA3_26560356_Chip-Seq_TH1_Human1.11478292
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10936520
102NFYA_21822215_ChIP-Seq_K562_Human1.10914278
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10281851
104EWS_26573619_Chip-Seq_HEK293_Human1.09947433
105RUNX_20019798_ChIP-Seq_JUKART_Human1.09544370
106RBPJ_21746931_ChIP-Seq_IB4_Human1.09465732
107* NANOG_18555785_Chip-Seq_ESCs_Mouse1.09254888
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09127022
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09122282
110* TCF4_23295773_ChIP-Seq_U87_Human1.09107288
111CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08881919
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08667484
113KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08667484
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08667484
115OCT4_18555785_Chip-Seq_ESCs_Mouse1.07976625
116GATA3_21878914_ChIP-Seq_MCF-7_Human1.07607709
117* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07425785
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07323068
119CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06791333
120KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06768583
121* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06708840
122TAF2_19829295_ChIP-Seq_ESCs_Human1.06540555
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06254068
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05919719
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05919719
126ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05752637
127GF1_26923725_Chip-Seq_HPCs_Mouse1.05724104
128* RNF2_27304074_Chip-Seq_NSC_Mouse1.05306195
129P53_22387025_ChIP-Seq_ESCs_Mouse1.05288349
130AHR_22903824_ChIP-Seq_MCF-7_Human1.04955210
131EZH2_27294783_Chip-Seq_NPCs_Mouse1.04900196
132CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04636523
133PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04332808
134RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03464281
135HOXB7_26014856_ChIP-Seq_BT474_Human1.03415883
136MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02756694
137P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.01998509
138FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01733143
139SALL4_22934838_ChIP-ChIP_CD34+_Human1.01306577
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01235939
141KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00988361
142CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00670459
143EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97920835
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97799783
145OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97120497
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96456112
147KLF4_18555785_Chip-Seq_ESCs_Mouse0.96423592
148RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95490463
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95352500
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.95110202
151ERG_20517297_ChIP-Seq_VCAP_Human0.95007996
152PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94897291
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.94261686
154* P300_18555785_Chip-Seq_ESCs_Mouse0.93339052
155TAF15_26573619_Chip-Seq_HEK293_Human0.92667346
156ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91344346
157STAT3_18555785_Chip-Seq_ESCs_Mouse0.90716974
158* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90093114
159SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89773546
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89755761
161SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89100274
162RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88849089
163SPI1_26923725_Chip-Seq_HPCs_Mouse0.86581870
164RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85123570
165PU1_27457419_Chip-Seq_LIVER_Mouse0.84874676
166MYC_27129775_Chip-Seq_CORNEA_Mouse0.83975359
167SOX9_26525672_Chip-Seq_HEART_Mouse0.83716633
168LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83627048
169CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83300073
170FLI1_21867929_ChIP-Seq_CD8_Mouse0.82671820
171RUNX1_27457419_Chip-Seq_LIVER_Mouse0.82542822
172GF1B_26923725_Chip-Seq_HPCs_Mouse0.82044211
173RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81431503
174EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81382984
175SMAD4_21741376_ChIP-Seq_EPCs_Human0.80706931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.01967420
2MP0001929_abnormal_gametogenesis5.62105398
3MP0008877_abnormal_DNA_methylation5.44344227
4MP0003718_maternal_effect5.24368029
5MP0002210_abnormal_sex_determination3.80676115
6MP0002161_abnormal_fertility/fecundity3.24405463
7MP0001145_abnormal_male_reproductive3.19717538
8MP0006292_abnormal_olfactory_placode2.94420689
9MP0002653_abnormal_ependyma_morphology2.83222001
10MP0000653_abnormal_sex_gland2.77717055
11MP0005395_other_phenotype2.16276356
12MP0001879_abnormal_lymphatic_vessel2.10652195
13MP0008057_abnormal_DNA_replication2.09161676
14MP0003252_abnormal_bile_duct2.01870300
15MP0005410_abnormal_fertilization15.5363347
16MP0002160_abnormal_reproductive_system1.96337656
17MP0005623_abnormal_meninges_morphology1.95539874
18MP0005670_abnormal_white_adipose1.82967163
19MP0008789_abnormal_olfactory_epithelium1.75118958
20MP0002163_abnormal_gland_morphology1.74624123
21MP0001348_abnormal_lacrimal_gland1.73536739
22MP0005646_abnormal_pituitary_gland1.70852543
23MP0009840_abnormal_foam_cell1.65457078
24MP0003941_abnormal_skin_development1.65341074
25MP0001968_abnormal_touch/_nociception1.64665174
26MP0002138_abnormal_hepatobiliary_system1.63251262
27MP0003119_abnormal_digestive_system1.57962980
28MP0008775_abnormal_heart_ventricle1.57530605
29MP0005394_taste/olfaction_phenotype1.51251208
30MP0005499_abnormal_olfactory_system1.51251208
31MP0009697_abnormal_copulation1.48715611
32MP0008004_abnormal_stomach_pH1.48530477
33MP0002009_preneoplasia1.48175547
34MP0001986_abnormal_taste_sensitivity1.43258397
35MP0000678_abnormal_parathyroid_gland1.41569257
36MP0000465_gastrointestinal_hemorrhage1.39795133
37MP0005647_abnormal_sex_gland1.31523236
38MP0002282_abnormal_trachea_morphology1.30434079
39MP0004782_abnormal_surfactant_physiolog1.29659078
40MP0008058_abnormal_DNA_repair1.27084506
41MP0003646_muscle_fatigue1.26327762
42MP0001873_stomach_inflammation1.21168443
43MP0001501_abnormal_sleep_pattern1.20013461
44MP0003011_delayed_dark_adaptation1.17393609
45MP0005310_abnormal_salivary_gland1.15836831
46MP0001486_abnormal_startle_reflex1.13317442
47MP0010094_abnormal_chromosome_stability1.11988956
48MP0009046_muscle_twitch1.08452684
49MP0005379_endocrine/exocrine_gland_phen1.04244294
50MP0008995_early_reproductive_senescence1.02240220
51MP0003191_abnormal_cellular_cholesterol1.02099317
52MP0002735_abnormal_chemical_nociception1.01581042
53MP0001765_abnormal_ion_homeostasis1.01419197
54MP0005389_reproductive_system_phenotype1.00766625
55MP0005083_abnormal_biliary_tract0.99575502
56MP0005360_urolithiasis0.99459226
57MP0001984_abnormal_olfaction0.98549780
58MP0000230_abnormal_systemic_arterial0.97878702
59MP0004233_abnormal_muscle_weight0.97404891
60MP0008007_abnormal_cellular_replicative0.96921863
61MP0003786_premature_aging0.93973923
62MP0010386_abnormal_urinary_bladder0.93736100
63MP0005167_abnormal_blood-brain_barrier0.92714740
64MP0009745_abnormal_behavioral_response0.92217973
65MP0000026_abnormal_inner_ear0.91887695
66MP0005085_abnormal_gallbladder_physiolo0.88299305
67MP0001346_abnormal_lacrimal_gland0.86979939
68MP0001963_abnormal_hearing_physiology0.86094430
69MP0004215_abnormal_myocardial_fiber0.83682976
70MP0006054_spinal_hemorrhage0.80545429
71MP0000569_abnormal_digit_pigmentation0.79954092
72MP0001664_abnormal_digestion0.77193773
73MP0002127_abnormal_cardiovascular_syste0.76657841
74MP0002132_abnormal_respiratory_system0.73101665
75MP0004134_abnormal_chest_morphology0.70991042
76MP0003693_abnormal_embryo_hatching0.69921450
77MP0001188_hyperpigmentation0.68844167
78MP0005645_abnormal_hypothalamus_physiol0.67658673
79MP0002272_abnormal_nervous_system0.67542147
80MP0003136_yellow_coat_color0.65158187
81MP0003890_abnormal_embryonic-extraembry0.65047869
82MP0001545_abnormal_hematopoietic_system0.64459430
83MP0005397_hematopoietic_system_phenotyp0.64459430
84MP0002234_abnormal_pharynx_morphology0.63829077
85MP0000613_abnormal_salivary_gland0.63237297
86MP0003950_abnormal_plasma_membrane0.59674068
87MP0005464_abnormal_platelet_physiology0.58498614
88MP0005084_abnormal_gallbladder_morpholo0.58328494
89MP0000049_abnormal_middle_ear0.58159392
90MP0000358_abnormal_cell_content/0.58112010
91MP0004808_abnormal_hematopoietic_stem0.56903044
92MP0010368_abnormal_lymphatic_system0.56593467
93MP0002006_tumorigenesis0.56278860
94MP0008770_decreased_survivor_rate0.54689729
95MP0003938_abnormal_ear_development0.53266590
96MP0000470_abnormal_stomach_morphology0.53102029
97MP0010307_abnormal_tumor_latency0.51890345
98MP0005636_abnormal_mineral_homeostasis0.51475241
99MP0004381_abnormal_hair_follicle0.51399501
100MP0003329_amyloid_beta_deposits0.49690278
101MP0004036_abnormal_muscle_relaxation0.48257762
102MP0003699_abnormal_female_reproductive0.47600632
103MP0009278_abnormal_bone_marrow0.47489407
104MP0004019_abnormal_vitamin_homeostasis0.47397302
105MP0003878_abnormal_ear_physiology0.46783120
106MP0005377_hearing/vestibular/ear_phenot0.46783120
107MP0002928_abnormal_bile_duct0.46163748
108MP0005253_abnormal_eye_physiology0.45397890
109MP0003115_abnormal_respiratory_system0.45255008
110MP0003111_abnormal_nucleus_morphology0.44267870
111MP0005551_abnormal_eye_electrophysiolog0.43896918
112MP0001324_abnormal_eye_pigmentation0.41470794
113MP0005666_abnormal_adipose_tissue0.41401424
114MP0001119_abnormal_female_reproductive0.39589993
115MP0001730_embryonic_growth_arrest0.38540055
116MP0001727_abnormal_embryo_implantation0.37844922
117MP0005391_vision/eye_phenotype0.34762308
118MP0002139_abnormal_hepatobiliary_system0.33605123
119MP0006036_abnormal_mitochondrial_physio0.33315860
120MP0001293_anophthalmia0.32815094
121MP0002269_muscular_atrophy0.30118627
122MP0006072_abnormal_retinal_apoptosis0.29777631
123MP0000427_abnormal_hair_cycle0.29618272
124MP0003077_abnormal_cell_cycle0.29468718
125MP0001764_abnormal_homeostasis0.28669250
126MP0003633_abnormal_nervous_system0.27517264
127MP0002971_abnormal_brown_adipose0.26643708
128MP0000313_abnormal_cell_death0.25578772
129MP0000604_amyloidosis0.25309700
130MP0003861_abnormal_nervous_system0.23899597
131MP0004811_abnormal_neuron_physiology0.23606738
132MP0000751_myopathy0.23415468
133MP0004133_heterotaxia0.23339633
134MP0009115_abnormal_fat_cell0.23189741
135MP0002152_abnormal_brain_morphology0.22816834
136MP0003631_nervous_system_phenotype0.21779160
137MP0002736_abnormal_nociception_after0.21164319
138MP0001851_eye_inflammation0.20247290
139MP0003879_abnormal_hair_cell0.19047477
140MP0002092_abnormal_eye_morphology0.18449221
141MP0002102_abnormal_ear_morphology0.18243005
142MP0002084_abnormal_developmental_patter0.18235774
143MP0008961_abnormal_basal_metabolism0.17841957
144MP0003045_fibrosis0.17284196
145MP0002169_no_abnormal_phenotype0.16085891
146MP0002873_normal_phenotype0.15865246
147MP0006138_congestive_heart_failure0.15593406
148MP0001661_extended_life_span0.15453571
149MP0000647_abnormal_sebaceous_gland0.15298205
150MP0005365_abnormal_bile_salt0.15127798
151MP0002229_neurodegeneration0.14620316
152MP0006035_abnormal_mitochondrial_morpho0.12801570
153MP0001672_abnormal_embryogenesis/_devel0.12520855
154MP0005380_embryogenesis_phenotype0.12520855
155MP0005195_abnormal_posterior_eye0.12163018
156MP0002970_abnormal_white_adipose0.12072269
157MP0003948_abnormal_gas_homeostasis0.12052090
158MP0000001_mammalian_phenotype0.12041676
159MP0004043_abnormal_pH_regulation0.11839176
160MP0001440_abnormal_grooming_behavior0.11745849
161MP0001697_abnormal_embryo_size0.11491805
162MP0004084_abnormal_cardiac_muscle0.11478624

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.83226723
2Abnormal respiratory motile cilium morphology (HP:0005938)9.17039080
3Abnormal respiratory epithelium morphology (HP:0012253)9.17039080
4Abnormal ciliary motility (HP:0012262)8.04412485
5Rhinitis (HP:0012384)8.01941129
6Chronic bronchitis (HP:0004469)7.79759685
7Nasal polyposis (HP:0100582)6.38210321
8* Infertility (HP:0000789)5.46988882
9Severe visual impairment (HP:0001141)5.43296886
10Abnormality of the nasal mucosa (HP:0000433)5.25088295
11Genetic anticipation (HP:0003743)5.24763768
12Prostate neoplasm (HP:0100787)4.97175710
13Progressive cerebellar ataxia (HP:0002073)4.76676170
14Bronchiectasis (HP:0002110)4.53764782
15Bronchitis (HP:0012387)4.50786542
16Nephronophthisis (HP:0000090)4.27958004
17Dysmetric saccades (HP:0000641)4.01022080
18Abnormality of abdominal situs (HP:0011620)3.81659918
19Abdominal situs inversus (HP:0003363)3.81659918
20Recurrent sinusitis (HP:0011108)3.72598357
21Hypophosphatemic rickets (HP:0004912)3.59384675
22Abnormality of the lower motor neuron (HP:0002366)3.48364380
23Gaze-evoked nystagmus (HP:0000640)3.37767509
24Action tremor (HP:0002345)3.36651170
25Recurrent otitis media (HP:0000403)3.30193256
26Male infertility (HP:0003251)3.29718858
27Abnormality of the renal medulla (HP:0100957)3.26827908
28Bony spicule pigmentary retinopathy (HP:0007737)3.22152206
29Attenuation of retinal blood vessels (HP:0007843)3.21460552
30Pendular nystagmus (HP:0012043)3.18202275
31Enlarged epiphyses (HP:0010580)3.04907397
32Postural instability (HP:0002172)3.01392887
33Abnormality of the hepatic vasculature (HP:0006707)2.97383803
34Abnormality of DNA repair (HP:0003254)2.96060167
35Gonadotropin excess (HP:0000837)2.95630188
36Anterior segment dysgenesis (HP:0007700)2.94936361
37Tubulointerstitial nephritis (HP:0001970)2.87535575
38Abnormality of the prostate (HP:0008775)2.84851644
39Abnormality of macular pigmentation (HP:0008002)2.82351522
40Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.79737352
41Abnormal spermatogenesis (HP:0008669)2.77914432
42Osteomalacia (HP:0002749)2.77857552
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.74421470
44Amyotrophic lateral sclerosis (HP:0007354)2.72358914
45Resting tremor (HP:0002322)2.71580983
46Dysdiadochokinesis (HP:0002075)2.71173213
47Generalized aminoaciduria (HP:0002909)2.66154668
48Fibular hypoplasia (HP:0003038)2.65383489
49Proximal tubulopathy (HP:0000114)2.59455881
50Optic nerve hypoplasia (HP:0000609)2.57262752
51Molar tooth sign on MRI (HP:0002419)2.55949165
52Abnormality of midbrain morphology (HP:0002418)2.55949165
53Atonic seizures (HP:0010819)2.48427511
54Medial flaring of the eyebrow (HP:0010747)2.48290284
55Chromsome breakage (HP:0040012)2.48209443
56Cerebellar dysplasia (HP:0007033)2.45030798
57Ectopic kidney (HP:0000086)2.44522640
58Type II lissencephaly (HP:0007260)2.44331857
59Tubular atrophy (HP:0000092)2.40889823
60Tubulointerstitial abnormality (HP:0001969)2.37822691
61Congenital sensorineural hearing impairment (HP:0008527)2.36213533
62Recurrent bronchitis (HP:0002837)2.31471114
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.29251170
64Impaired vibratory sensation (HP:0002495)2.25459001
65Fair hair (HP:0002286)2.23828972
66Urinary bladder sphincter dysfunction (HP:0002839)2.23220397
67Absence seizures (HP:0002121)2.21382481
68Abnormality of the labia minora (HP:0012880)2.21290192
69Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.18802144
70Hypoplasia of the uterus (HP:0000013)2.15049349
71Clumsiness (HP:0002312)2.14980120
72Hematochezia (HP:0002573)2.14461062
73Hypoplasia of the brainstem (HP:0002365)2.14238436
74Aplasia/Hypoplasia of the brainstem (HP:0007362)2.14238436
75Hyperkalemia (HP:0002153)2.12433026
76Small intestinal stenosis (HP:0012848)2.10853953
77Duodenal stenosis (HP:0100867)2.10853953
78Impaired proprioception (HP:0010831)2.09005006
79Intellectual disability, profound (HP:0002187)2.07201584
80Aplasia/Hypoplasia of the earlobes (HP:0009906)2.04663983
81Postaxial foot polydactyly (HP:0001830)2.03194699
82Azoospermia (HP:0000027)2.03045134
83Upper motor neuron abnormality (HP:0002127)2.00135935
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8760112
85Absent/shortened dynein arms (HP:0200106)13.3265392
86Dynein arm defect of respiratory motile cilia (HP:0012255)13.3265392
87Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99271242
88Impulsivity (HP:0100710)1.98709844
89Retinal dysplasia (HP:0007973)1.97058537
90Abnormality of male internal genitalia (HP:0000022)1.95951160
91Hypoplastic ischia (HP:0003175)1.95902827
92Stage 5 chronic kidney disease (HP:0003774)1.93320970
93Hypoplastic labia majora (HP:0000059)1.91100381
94Abnormality of the costochondral junction (HP:0000919)1.90337052
95Abnormality of lateral ventricle (HP:0030047)1.90172982
96Absent frontal sinuses (HP:0002688)1.86425658
97Oligodactyly (hands) (HP:0001180)1.85770540
98Tubulointerstitial fibrosis (HP:0005576)1.84989631
99Short middle phalanx of the 5th finger (HP:0004220)1.83144356
100Abnormality of the ileum (HP:0001549)1.83037764
101Abnormality of permanent molar morphology (HP:0011071)1.82845645
102Abnormality of the dental root (HP:0006486)1.82845645
103Taurodontia (HP:0000679)1.82845645
104Inability to walk (HP:0002540)1.82555522
105Abnormality of the renal cortex (HP:0011035)1.80700478
106Facial hemangioma (HP:0000329)1.80598861
107Hypoalbuminemia (HP:0003073)1.79741076
108Abnormal albumin level (HP:0012116)1.79741076
109Congenital hepatic fibrosis (HP:0002612)1.78485147
110Abnormality of the anterior horn cell (HP:0006802)1.78121746
111Degeneration of anterior horn cells (HP:0002398)1.78121746
112Meckel diverticulum (HP:0002245)1.77807342
113Cone-rod dystrophy (HP:0000548)1.77543129
114Clubbing of toes (HP:0100760)1.76119195
115J-shaped sella turcica (HP:0002680)1.76056780
11611 pairs of ribs (HP:0000878)1.75244418
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.73920276
118Abnormality of dentin (HP:0010299)1.73657771
119Rickets (HP:0002748)1.72860073
120Impaired smooth pursuit (HP:0007772)1.71113704
121Oculomotor apraxia (HP:0000657)1.70857377
122Abnormality of molar (HP:0011077)1.70208009
123Abnormality of molar morphology (HP:0011070)1.70208009
124Short ribs (HP:0000773)1.69960229
125Abnormality of the labia majora (HP:0012881)1.69561918
126Abnormality of the duodenum (HP:0002246)1.69379764
127Microglossia (HP:0000171)1.68738764
128Horizontal nystagmus (HP:0000666)1.68570423
129Aplasia/Hypoplasia of the fovea (HP:0008060)1.68263133
130Hypoplasia of the fovea (HP:0007750)1.68263133
131Aplasia/Hypoplasia of the fibula (HP:0006492)1.68150138
132Hypochromic microcytic anemia (HP:0004840)1.67423666
133Abnormal rod and cone electroretinograms (HP:0008323)1.67395629
134Abnormality of the dental pulp (HP:0006479)1.66614095
135Polydipsia (HP:0001959)1.65229325
136Abnormal drinking behavior (HP:0030082)1.65229325
137Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62229263
138Renal dysplasia (HP:0000110)1.62101230
139Absent epiphyses (HP:0010577)1.57131256
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57131256
141Chronic sinusitis (HP:0011109)1.57056005
142Supernumerary spleens (HP:0009799)1.56166757
143Abnormality of renal excretion (HP:0011036)1.55316074
144Facial cleft (HP:0002006)1.54548626
145Postaxial hand polydactyly (HP:0001162)1.52594457
146Spastic tetraparesis (HP:0001285)1.50344000
147Breast carcinoma (HP:0003002)1.48798261
148Cholecystitis (HP:0001082)1.46675238
149Abnormal gallbladder physiology (HP:0012438)1.46675238
150Cystic liver disease (HP:0006706)1.42760590
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.40954807
152Selective tooth agenesis (HP:0001592)1.40387425
153Dyschromatopsia (HP:0007641)1.40032378
154Gait imbalance (HP:0002141)1.39193673
155Congenital primary aphakia (HP:0007707)1.38954239
156Broad distal phalanx of finger (HP:0009836)1.37684551
157Heterotopia (HP:0002282)1.36793641
158Large eyes (HP:0001090)1.36737505
159Deformed sella turcica (HP:0002681)1.35235865
160Short thorax (HP:0010306)1.32606801
161Bell-shaped thorax (HP:0001591)1.31590249
162Median cleft lip (HP:0000161)1.30982414
163Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.30070835
164Pancreatic fibrosis (HP:0100732)1.29993838
165Hypoplasia of dental enamel (HP:0006297)1.27476225
166Conjunctival telangiectasia (HP:0000524)1.27322025
167Vascular calcification (HP:0004934)1.26087936
168Nephropathy (HP:0000112)1.23433892
169Aplasia/Hypoplasia of the lens (HP:0008063)1.23049578
170Abnormality of ocular smooth pursuit (HP:0000617)1.19069677
171Decreased central vision (HP:0007663)1.19043620
172Abnormal biliary tract physiology (HP:0012439)1.18528346
173Bile duct proliferation (HP:0001408)1.18528346
174Pachygyria (HP:0001302)1.17485187
175Nephrogenic diabetes insipidus (HP:0009806)1.17381255
176Decreased motor nerve conduction velocity (HP:0003431)1.17321171
177Short nail (HP:0001799)1.14886285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.45291465
2PDK39.45291465
3PDK26.14439972
4TESK14.16488536
5CDK194.01122907
6ZAK3.94713133
7ACVR1B3.59931292
8OXSR13.45085288
9PRKD33.31662740
10TAOK33.29297525
11FRK2.94841695
12ICK2.85556113
13MAP3K92.85324245
14ARAF2.77098369
15MAP3K132.42643771
16PTK2B2.34239127
17WNK42.31485577
18STK392.26180268
19PNCK2.25652783
20INSRR1.92973876
21NEK21.83017882
22DDR21.69008656
23PLK21.51563316
24TLK11.51413722
25TIE11.39224674
26MAP4K21.38109244
27FES1.37438523
28GRK11.30775438
29STK381.28296411
30TNK21.25958895
31ADRBK21.14148245
32CDK91.05971118
33MAP2K21.03397949
34WNK11.01554891
35PDK10.96846701
36TNIK0.93309409
37PASK0.93182858
38MAPK150.93004459
39FGR0.92940163
40CASK0.91878853
41CCNB10.91518931
42TYRO30.91254650
43DYRK1B0.90592666
44MET0.89182810
45STK30.87036999
46CDK70.78727951
47JAK10.78621129
48MST1R0.77709393
49AURKA0.77194652
50MYLK0.75630105
51GRK60.75232759
52CDC70.75106296
53DYRK30.74644505
54RPS6KA50.71405551
55TTK0.66769741
56IRAK10.64257229
57NUAK10.62497883
58PINK10.60759904
59WEE10.56963969
60VRK10.54351678
61TESK20.50910114
62MOS0.50051255
63TEC0.49952082
64BRD40.49401274
65ATR0.47730285
66MKNK20.47294813
67JAK30.46193349
68CHEK10.46180203
69CHEK20.45541381
70LMTK20.45495866
71KSR20.44603101
72PIK3CG0.44164540
73CAMK1G0.43244660
74PLK30.42387844
75CDK40.40611874
76MAP3K80.39238462
77PIM10.36692119
78PDPK10.36440537
79SYK0.35539081
80FER0.35513462
81STK38L0.34758218
82NTRK20.34223533
83TRPM70.33926214
84MAPKAPK30.33899129
85CLK10.33861042
86EEF2K0.33229663
87MAP2K60.32803695
88ATM0.32588780
89ERBB30.32462888
90NLK0.28805134
91CAMKK10.28527819
92BMPR1B0.28383879
93BLK0.26335417
94PLK40.25660201
95PAK10.25497768
96STK160.24769560
97PLK10.23294015
98MUSK0.23030119
99PRKCG0.23000909
100MTOR0.22338402
101RIPK40.21527456
102IRAK20.20952932
103PAK20.20156622
104MAPKAPK50.19140761
105RPS6KB10.18301325
106PRKAA10.17802368
107MAP3K100.15391281
108MARK20.13927839
109BRAF0.13026451
110CDK120.10619574
111MAP3K40.08954027
112NEK60.08935049
113BRSK20.08859954
114WNK30.08224194
115PRKACG0.08033156
116CDK150.07853665
117PRKG10.07684835
118CSNK1D0.06515080
119CDK180.05645335
120PRKCQ0.05626141
121CSNK2A10.05530749
122CDK10.04741826
123CDK11A0.04582239
124MARK30.04269918
125PRKCZ0.04159960
126CSF1R0.03810389
127STK100.03198002
128MAPK80.03108855
129PRKACB0.02586677
130CDK20.02554453
131CDK140.02554445
132PAK60.02437782
133PRKDC0.02081589
134GSK3B0.01861432
135RPS6KA10.00772449
136PAK40.00519949
137STK110.00380711
138MAPK1-0.0494869
139ZAP70-0.0487995
140CSK-0.0478666
141INSR-0.0448119
142PDGFRB-0.0403776
143PRKACA-0.0327988
144MAPK10-0.0325418
145BUB1-0.0309579
146PRKCA-0.0275712
147PKN1-0.0184226
148CAMK2A-0.0178186
149EGFR-0.0151424
150RPS6KA3-0.0091061
151PRKG2-0.0086454
152PRKCB-0.0066479
153BRSK1-0.0065638
154CSNK2A2-0.0014239

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.99531846
2Pyruvate metabolism_Homo sapiens_hsa006204.64147334
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.28312057
4Propanoate metabolism_Homo sapiens_hsa006403.80330552
5Fatty acid biosynthesis_Homo sapiens_hsa000613.14924001
6Glucagon signaling pathway_Homo sapiens_hsa049223.04626256
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72759380
8Pentose phosphate pathway_Homo sapiens_hsa000302.68027413
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.63206392
10Basal transcription factors_Homo sapiens_hsa030222.59134613
11Selenocompound metabolism_Homo sapiens_hsa004502.55729093
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.52420014
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.40912980
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.27236994
15RNA polymerase_Homo sapiens_hsa030202.21078314
16Linoleic acid metabolism_Homo sapiens_hsa005912.18579285
17Fanconi anemia pathway_Homo sapiens_hsa034602.14077837
18Dorso-ventral axis formation_Homo sapiens_hsa043202.00572438
19Oocyte meiosis_Homo sapiens_hsa041141.97430921
20Glycerolipid metabolism_Homo sapiens_hsa005611.91215641
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.89984466
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.82275988
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.70900309
24PPAR signaling pathway_Homo sapiens_hsa033201.70824860
25Amphetamine addiction_Homo sapiens_hsa050311.69682872
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.66932131
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63108566
28Huntingtons disease_Homo sapiens_hsa050161.61108837
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.51124782
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49298764
31Gap junction_Homo sapiens_hsa045401.48906518
32Morphine addiction_Homo sapiens_hsa050321.47042282
33Renin secretion_Homo sapiens_hsa049241.46924574
34Nicotine addiction_Homo sapiens_hsa050331.46668248
35Carbon metabolism_Homo sapiens_hsa012001.46580598
36Caffeine metabolism_Homo sapiens_hsa002321.46070665
37Primary immunodeficiency_Homo sapiens_hsa053401.44548860
38Phototransduction_Homo sapiens_hsa047441.38695341
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30262471
40Fructose and mannose metabolism_Homo sapiens_hsa000511.27351092
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27183435
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26865818
43Tryptophan metabolism_Homo sapiens_hsa003801.26776466
44Ovarian steroidogenesis_Homo sapiens_hsa049131.26050901
45Butanoate metabolism_Homo sapiens_hsa006501.24370202
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21612518
47Cardiac muscle contraction_Homo sapiens_hsa042601.19780851
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14645528
49Nucleotide excision repair_Homo sapiens_hsa034201.12997129
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.10005208
51mRNA surveillance pathway_Homo sapiens_hsa030151.08069624
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06879250
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06578392
54Biosynthesis of amino acids_Homo sapiens_hsa012301.04036705
55Serotonergic synapse_Homo sapiens_hsa047261.03816248
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02734922
57RNA transport_Homo sapiens_hsa030131.01171238
58Fat digestion and absorption_Homo sapiens_hsa049751.00984146
59Long-term potentiation_Homo sapiens_hsa047201.00258393
60Fatty acid metabolism_Homo sapiens_hsa012120.98749938
61Purine metabolism_Homo sapiens_hsa002300.95745583
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94788115
63Fatty acid degradation_Homo sapiens_hsa000710.93492218
64Ether lipid metabolism_Homo sapiens_hsa005650.93312249
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93084536
66Antigen processing and presentation_Homo sapiens_hsa046120.90266172
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89972298
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85795621
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84384250
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83897607
71Mineral absorption_Homo sapiens_hsa049780.81989930
72Platelet activation_Homo sapiens_hsa046110.80847464
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79700320
74Nitrogen metabolism_Homo sapiens_hsa009100.78958782
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78786214
76ABC transporters_Homo sapiens_hsa020100.73513196
77GABAergic synapse_Homo sapiens_hsa047270.71846213
78Glutathione metabolism_Homo sapiens_hsa004800.69529314
79Collecting duct acid secretion_Homo sapiens_hsa049660.69454834
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65601478
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.65331341
82Chemical carcinogenesis_Homo sapiens_hsa052040.65209007
83VEGF signaling pathway_Homo sapiens_hsa043700.64665503
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64542190
85Estrogen signaling pathway_Homo sapiens_hsa049150.61184779
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60861439
87Proteasome_Homo sapiens_hsa030500.60209474
88Calcium signaling pathway_Homo sapiens_hsa040200.58764639
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55076412
90Oxytocin signaling pathway_Homo sapiens_hsa049210.54838949
91Vitamin digestion and absorption_Homo sapiens_hsa049770.54115210
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52171027
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51245498
94DNA replication_Homo sapiens_hsa030300.49785086
95p53 signaling pathway_Homo sapiens_hsa041150.46854047
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45033821
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.43702502
98AMPK signaling pathway_Homo sapiens_hsa041520.42456434
99Insulin secretion_Homo sapiens_hsa049110.42455274
100Arachidonic acid metabolism_Homo sapiens_hsa005900.41819887
101Cholinergic synapse_Homo sapiens_hsa047250.41618989
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.40942163
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38847911
104N-Glycan biosynthesis_Homo sapiens_hsa005100.38348409
105B cell receptor signaling pathway_Homo sapiens_hsa046620.36673751
106Bile secretion_Homo sapiens_hsa049760.36026350
107Metabolic pathways_Homo sapiens_hsa011000.35855266
108Thyroid hormone synthesis_Homo sapiens_hsa049180.35154907
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.34845320
110Inositol phosphate metabolism_Homo sapiens_hsa005620.33515419
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.33501327
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32553481
113Arginine and proline metabolism_Homo sapiens_hsa003300.32466786
114Legionellosis_Homo sapiens_hsa051340.32444126
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32345028
116Hedgehog signaling pathway_Homo sapiens_hsa043400.32115360
117Systemic lupus erythematosus_Homo sapiens_hsa053220.30837015
118Base excision repair_Homo sapiens_hsa034100.29682464
119Endocytosis_Homo sapiens_hsa041440.29626259
120Autoimmune thyroid disease_Homo sapiens_hsa053200.29590099
121Ras signaling pathway_Homo sapiens_hsa040140.28774768
122Synaptic vesicle cycle_Homo sapiens_hsa047210.28143242
123Renin-angiotensin system_Homo sapiens_hsa046140.27840289
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27602456
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.26274694
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.24817202
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24517741
128Long-term depression_Homo sapiens_hsa047300.24450178
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24219672
130Circadian entrainment_Homo sapiens_hsa047130.24163858
131T cell receptor signaling pathway_Homo sapiens_hsa046600.23741951
132Taste transduction_Homo sapiens_hsa047420.22257101
133Wnt signaling pathway_Homo sapiens_hsa043100.21695774
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21307660
135Retinol metabolism_Homo sapiens_hsa008300.20504485
136Pyrimidine metabolism_Homo sapiens_hsa002400.19694216
137Glutamatergic synapse_Homo sapiens_hsa047240.18583999
138Cell cycle_Homo sapiens_hsa041100.18431372
139cAMP signaling pathway_Homo sapiens_hsa040240.18382714
140RNA degradation_Homo sapiens_hsa030180.18326862
141Pancreatic secretion_Homo sapiens_hsa049720.17995197
142Salivary secretion_Homo sapiens_hsa049700.17737746
143Sulfur metabolism_Homo sapiens_hsa009200.16247971
144Protein digestion and absorption_Homo sapiens_hsa049740.14012300
145Viral carcinogenesis_Homo sapiens_hsa052030.13966266
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.13681614
147Homologous recombination_Homo sapiens_hsa034400.13398577
148Olfactory transduction_Homo sapiens_hsa047400.12758505
149Gastric acid secretion_Homo sapiens_hsa049710.11962097

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