SPATA18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a p53-inducible protein that is able to induce lysosome-like organelles within mitochondria that eliminate oxidized mitochondrial proteins, thereby contributing to mitochondrial quality control. Dysregulation of mitochondrial quality control is associated with cancer and degenerative diseases. The encoded protein mediates accumulation of the lysosome-like mitochondrial organelles through interaction with B cell lymphoma 2 interacting protein 3 and B cell lymphoma 2 interacting protein 3 like at the outer mitochondrial membrane, which allows translocation of lysosomal proteins to the mitochondrial matrix from the cytosol. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.97352037
2spermatid development (GO:0007286)9.92500282
3motile cilium assembly (GO:0044458)9.64825215
4reproduction (GO:0000003)9.23253222
5regulation of cilium movement (GO:0003352)9.21962543
6cilium or flagellum-dependent cell motility (GO:0001539)9.19361832
7cilium movement (GO:0003341)8.28977774
8negative regulation of inclusion body assembly (GO:0090084)7.68812728
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.52223489
10sperm capacitation (GO:0048240)7.43977588
11single fertilization (GO:0007338)7.37864241
12organic cation transport (GO:0015695)6.90416191
13synaptonemal complex organization (GO:0070193)6.88186898
14spermatogenesis (GO:0007283)6.87521242
15primary alcohol catabolic process (GO:0034310)6.86732812
16male gamete generation (GO:0048232)6.84942972
17left/right axis specification (GO:0070986)6.81281371
18male meiosis (GO:0007140)6.67249126
19synaptonemal complex assembly (GO:0007130)6.66397754
20microtubule depolymerization (GO:0007019)6.59401070
21piRNA metabolic process (GO:0034587)6.56450304
22regulation of inclusion body assembly (GO:0090083)6.32909770
23gamete generation (GO:0007276)6.29245810
24fertilization (GO:0009566)6.27443383
25microtubule bundle formation (GO:0001578)6.05485256
26vitamin transmembrane transport (GO:0035461)5.97597616
27ethanol metabolic process (GO:0006067)5.91491167
28calcium ion-dependent exocytosis (GO:0017156)5.70288144
29diterpenoid biosynthetic process (GO:0016102)5.56146557
30regulation of microtubule-based movement (GO:0060632)5.51750424
31germ cell development (GO:0007281)5.48619235
32chromosome condensation (GO:0030261)5.42285730
33cellular process involved in reproduction in multicellular organism (GO:0022412)5.40556793
34ventricular system development (GO:0021591)5.38629556
35DNA packaging (GO:0006323)5.16468498
36glycerol ether metabolic process (GO:0006662)5.09388858
37cell recognition (GO:0008037)5.00870639
38multicellular organismal reproductive process (GO:0048609)4.97341899
39spermatid nucleus differentiation (GO:0007289)4.92387137
40glomerular epithelial cell development (GO:0072310)4.86569449
41establishment of apical/basal cell polarity (GO:0035089)4.83103472
42male meiosis I (GO:0007141)4.81803036
43microtubule severing (GO:0051013)4.78817712
44response to xenobiotic stimulus (GO:0009410)4.72011333
45ether metabolic process (GO:0018904)4.70718629
46pyrimidine-containing compound transmembrane transport (GO:0072531)4.64163308
47left/right pattern formation (GO:0060972)4.63157176
48seminiferous tubule development (GO:0072520)4.61575267
49ethanol oxidation (GO:0006069)4.61427662
50lung epithelium development (GO:0060428)4.55041487
51one-carbon compound transport (GO:0019755)4.50784500
52chromosome organization involved in meiosis (GO:0070192)4.44047679
53regulation of interleukin-5 production (GO:0032674)4.41275632
54negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.36119486
55sexual reproduction (GO:0019953)4.31658362
56regulation of interleukin-13 production (GO:0032656)4.27177391
57tolerance induction (GO:0002507)4.23412309
58establishment or maintenance of monopolar cell polarity (GO:0061339)4.15763767
59establishment of monopolar cell polarity (GO:0061162)4.15763767
60DNA methylation involved in gamete generation (GO:0043046)4.15365315
61chaperone-mediated protein complex assembly (GO:0051131)4.14128949
62negative regulation of humoral immune response (GO:0002921)4.09196344
63cell projection assembly (GO:0030031)4.01177924
64meiotic nuclear division (GO:0007126)3.99640448
65multicellular organismal development (GO:0007275)3.98822775
66single strand break repair (GO:0000012)3.94739144
67negative regulation of T cell differentiation in thymus (GO:0033085)3.90468161
68establishment of tissue polarity (GO:0007164)3.88246211
69establishment of planar polarity (GO:0001736)3.88246211
70meiosis I (GO:0007127)3.83323130
71terpenoid biosynthetic process (GO:0016114)3.76948957
72retinoic acid metabolic process (GO:0042573)3.72601599
73positive regulation of smoothened signaling pathway (GO:0045880)3.69966071
74lateral ventricle development (GO:0021670)3.64851679
75protein polyglutamylation (GO:0018095)3.64507760
76negative regulation of B cell mediated immunity (GO:0002713)3.63542570
77negative regulation of immunoglobulin mediated immune response (GO:0002890)3.63542570
78positive regulation of tolerance induction (GO:0002645)3.58042569
79protein refolding (GO:0042026)3.57473201
80genitalia morphogenesis (GO:0035112)3.54204247
81cytoplasmic microtubule organization (GO:0031122)3.47979219
82regulation of germinal center formation (GO:0002634)3.38695820
83microtubule polymerization or depolymerization (GO:0031109)3.36085246
84regulation of spindle checkpoint (GO:0090231)3.32258256
85sequestering of actin monomers (GO:0042989)3.30149332
86glycolytic process (GO:0006096)3.23667007
87meiotic cell cycle (GO:0051321)3.21202822
88protein K11-linked deubiquitination (GO:0035871)3.17180808
89carnitine transport (GO:0015879)3.16472182
90amino-acid betaine transport (GO:0015838)3.16472182
91primary alcohol metabolic process (GO:0034308)3.14739882
92protein localization to cilium (GO:0061512)3.14591203
93nucleus organization (GO:0006997)3.12158635
94RNA localization (GO:0006403)3.11777217
95nucleoside diphosphate phosphorylation (GO:0006165)3.09830668
96O-glycan processing (GO:0016266)3.08876827
97retinol metabolic process (GO:0042572)3.08687854
98RNA destabilization (GO:0050779)3.05798146
99centriole replication (GO:0007099)3.00829615
100monoubiquitinated protein deubiquitination (GO:0035520)2.99636956
101polyamine biosynthetic process (GO:0006596)2.99331000
102interferon-gamma secretion (GO:0072643)2.98801082
103mitotic sister chromatid cohesion (GO:0007064)2.98208501
104carnitine transmembrane transport (GO:1902603)2.95534706
105phosphatidylethanolamine biosynthetic process (GO:0006646)2.93730056
106polyol catabolic process (GO:0046174)2.93515414
107positive regulation of macrophage activation (GO:0043032)2.92820994
108exogenous drug catabolic process (GO:0042738)2.88748010
109cilium organization (GO:0044782)2.88711616
110regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.85538824
111alditol metabolic process (GO:0019400)2.85050457
112dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.82111917
113microtubule-based movement (GO:0007018)2.80856917
114axoneme assembly (GO:0035082)2.79561326
115determination of left/right symmetry (GO:0007368)2.78133103
116cilium assembly (GO:0042384)2.77995961
117regulation of cilium assembly (GO:1902017)2.76601024
118carnitine metabolic process (GO:0009437)2.76311696
119GTP biosynthetic process (GO:0006183)2.76163692
120regulation of apoptotic cell clearance (GO:2000425)2.72599915
121glutathione derivative biosynthetic process (GO:1901687)2.71010048
122glutathione derivative metabolic process (GO:1901685)2.71010048
123cellular component assembly involved in morphogenesis (GO:0010927)2.70615101
124phosphatidylethanolamine metabolic process (GO:0046337)2.69874587
125lateral sprouting from an epithelium (GO:0060601)2.69809340
126cilium morphogenesis (GO:0060271)2.68954867
127hypotonic response (GO:0006971)2.68499190
128determination of bilateral symmetry (GO:0009855)2.68285177
129metanephric mesenchyme development (GO:0072075)2.68176775
130smoothened signaling pathway (GO:0007224)2.66638981
131progesterone metabolic process (GO:0042448)2.66411194
132multicellular organismal water homeostasis (GO:0050891)2.65812680
133intraciliary transport (GO:0042073)2.64621449
134specification of symmetry (GO:0009799)2.63099884
135meiotic cell cycle process (GO:1903046)2.63051506
136apical protein localization (GO:0045176)2.62292222
137chromatin silencing (GO:0006342)2.60499254
138microtubule-based process (GO:0007017)2.58859323
139regulation of tolerance induction (GO:0002643)2.57997731
140negative regulation of organelle assembly (GO:1902116)2.57560184
141embryonic camera-type eye development (GO:0031076)2.57282271
142excretion (GO:0007588)2.57209420
143positive regulation of glycolytic process (GO:0045821)2.56909496
144peptidyl-glutamic acid modification (GO:0018200)2.55455566
145phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.51204960
146synapsis (GO:0007129)2.48758069
147phosphatidylcholine biosynthetic process (GO:0006656)2.48237766
148centriole assembly (GO:0098534)2.47754426
149CDP-diacylglycerol biosynthetic process (GO:0016024)2.46721002
150UTP biosynthetic process (GO:0006228)2.46477966
151organelle assembly (GO:0070925)2.45572404
152regulation of response to osmotic stress (GO:0047484)2.44727575
153regulation of microtubule depolymerization (GO:0031114)2.43846105
154kidney mesenchyme development (GO:0072074)2.41169554
155regulation of protein kinase C signaling (GO:0090036)2.40731433
156heart looping (GO:0001947)2.40400960
157retinal rod cell development (GO:0046548)2.38762695
158calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.38368194
159regulation of smoothened signaling pathway (GO:0008589)2.35421974
160sperm motility (GO:0030317)14.4423321
161fusion of sperm to egg plasma membrane (GO:0007342)13.2885699
162acrosome reaction (GO:0007340)12.5695186
163cell wall macromolecule metabolic process (GO:0044036)12.4657614
164cell wall macromolecule catabolic process (GO:0016998)12.4657614
165sperm-egg recognition (GO:0035036)11.5055934
166acrosome assembly (GO:0001675)11.0904475
167multicellular organism reproduction (GO:0032504)10.6370889
168binding of sperm to zona pellucida (GO:0007339)10.4501522
169cell-cell recognition (GO:0009988)10.2919221
170plasma membrane fusion (GO:0045026)10.1387737
171epithelial cilium movement (GO:0003351)10.0399035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.83252237
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.22704186
3EZH2_22144423_ChIP-Seq_EOC_Human4.25640813
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.82566100
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.30201360
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.11626359
7DROSHA_22980978_ChIP-Seq_HELA_Human3.10507563
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.95402486
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.94604282
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.94560372
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.65664149
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.27761563
13* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.21484324
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07660597
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04373125
16ZNF274_21170338_ChIP-Seq_K562_Hela2.01506224
17AHR_22903824_ChIP-Seq_MCF-7_Human2.01196995
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.90664643
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.84174002
20ARNT_22903824_ChIP-Seq_MCF-7_Human1.83477297
21ELK4_26923725_Chip-Seq_MESODERM_Mouse1.81498473
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.80099602
23FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79423984
24RUNX1_27514584_Chip-Seq_MCF-7_Human1.74624513
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.74182875
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.74057920
27KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.73825895
28STAT1_17558387_ChIP-Seq_HELA_Human1.73120370
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72663352
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.70406478
31* TP63_23658742_ChIP-Seq_EP156T_Human1.69682528
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69434794
33SOX2_22085726_ChIP-Seq_NPCs_Mouse1.69056339
34* TP53_18474530_ChIP-ChIP_U2OS_Human1.68739490
35SOX2_27498859_Chip-Seq_STOMACH_Mouse1.67930304
36FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.67308958
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.64869675
38SMC4_20622854_ChIP-Seq_HELA_Human1.63982462
39* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63889633
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.60499690
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.56587364
42* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.55602271
43* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55432258
44GATA3_21867929_ChIP-Seq_CD8_Mouse1.54627954
45* TRIM28_21343339_ChIP-Seq_HEK293_Human1.54554583
46FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53809109
47GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52733981
48TP63_22573176_ChIP-Seq_HFKS_Human1.49796229
49KLF5_25053715_ChIP-Seq_YYC3_Human1.48776885
50FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47963888
51CBP_20019798_ChIP-Seq_JUKART_Human1.47034448
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47034448
53PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45843149
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42627215
55KDM2B_26808549_Chip-Seq_REH_Human1.41986413
56AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39936938
57STAT1_20625510_ChIP-Seq_HELA_Human1.39870967
58P53_21459846_ChIP-Seq_SAOS-2_Human1.38930611
59CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36928937
60LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.36677854
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36150798
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34200019
63* TAL1_26923725_Chip-Seq_HPCs_Mouse1.33189283
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32884853
65TDRD3_21172665_ChIP-Seq_MCF-7_Human1.32225586
66ETV1_20927104_ChIP-Seq_GIST48_Human1.32206468
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31054084
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30719073
69* REST_21632747_ChIP-Seq_MESCs_Mouse1.29760379
70SOX2_20726797_ChIP-Seq_SW620_Human1.29544662
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29136325
72RAD21_21589869_ChIP-Seq_MESCs_Mouse1.27792937
73HNFA_21074721_ChIP-Seq_CACO-2_Human1.26960298
74GATA3_21867929_ChIP-Seq_TH1_Mouse1.25804686
75KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25614611
76* VDR_22108803_ChIP-Seq_LS180_Human1.24622093
77PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.24589991
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.24456555
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24091010
80CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23028857
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23022223
82CTCF_27219007_Chip-Seq_Bcells_Human1.22243277
83CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.21673451
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.21441833
85CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21192910
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21057152
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.20702439
88FOXA1_25552417_ChIP-Seq_VCAP_Human1.19711227
89GATA1_19941826_ChIP-Seq_K562_Human1.19048919
90SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18422589
91PHF8_20622853_ChIP-Seq_HELA_Human1.18351427
92RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17015358
93* GF1_26923725_Chip-Seq_HPCs_Mouse1.15912828
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15610269
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15574308
96MYC_27129775_Chip-Seq_CORNEA_Mouse1.15318389
97SPI1_26923725_Chip-Seq_HPCs_Mouse1.15225998
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.15121407
99SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14956622
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14293738
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14293738
102CDX2_20551321_ChIP-Seq_CACO-2_Human1.13369852
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12559992
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12103709
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.11975353
106TAF15_26573619_Chip-Seq_HEK293_Human1.11900240
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11815537
108ERG_20517297_ChIP-Seq_VCAP_Human1.11812017
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11654320
110RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11408111
111RBPJ_21746931_ChIP-Seq_IB4_Human1.10459213
112SMRT_27268052_Chip-Seq_Bcells_Human1.10352787
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09471703
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09341688
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09274512
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09090405
117RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08891089
118EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08691147
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08174442
120GATA1_19941827_ChIP-Seq_MEL86_Mouse1.08091295
121TET1_21451524_ChIP-Seq_MESCs_Mouse1.07763698
122CTCF_20526341_ChIP-Seq_ESCs_Human1.07559852
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07285057
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06906016
125CBX2_22325352_ChIP-Seq_293T-Rex_Human1.06161693
126JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05879102
127NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05540424
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04669056
129GATA4_25053715_ChIP-Seq_YYC3_Human1.03785272
130ESET_19884257_ChIP-Seq_ESCs_Mouse1.02941394
131RARA_24833708_ChIP-Seq_LIVER_Mouse1.02633661
132* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02527503
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02364613
134ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01615851
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01487908
136PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01441805
137YY1_22570637_ChIP-Seq_MALME-3M_Human1.01343642
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99759289
139NFYA_21822215_ChIP-Seq_K562_Human0.98903679
140SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98900140
141ELF1_20517297_ChIP-Seq_JURKAT_Human0.98829136
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.98766936
143PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98361554
144CRX_20693478_ChIP-Seq_RETINA_Mouse0.98294960
145SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97817652
146SOX11_22085726_ChIP-Seq_ESNs_Mouse0.97517375
147LXR_22292898_ChIP-Seq_THP-1_Human0.96943535
148GATA3_24758297_ChIP-Seq_MCF-7_Human0.96799654
149GATA6_21074721_ChIP-Seq_CACO-2_Human0.96666665
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.95282093
151RACK7_27058665_Chip-Seq_MCF-7_Human0.95037371
152NFYB_21822215_ChIP-Seq_K562_Human0.95006288
153TP53_16413492_ChIP-PET_HCT116_Human0.94803503
154* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94789850
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94469248
156GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93120766
157BCOR_27268052_Chip-Seq_Bcells_Human0.92682825
158LXR_22158963_ChIP-Seq_LIVER_Mouse0.92047020
159LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91834128
160CEBPB_22108803_ChIP-Seq_LS180_Human0.91612549
161P68_20966046_ChIP-Seq_HELA_Human0.91438702
162* SMAD4_21799915_ChIP-Seq_A2780_Human0.91058884
163SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90986371
164NANOG_20526341_ChIP-Seq_ESCs_Human0.90737964
165FLI1_21867929_ChIP-Seq_CD8_Mouse0.90543162
166OCT1_27270436_Chip-Seq_PROSTATE_Human0.90176784
167* EZH2_27294783_Chip-Seq_ESCs_Mouse0.89930555
168TBL1_22424771_ChIP-Seq_293T_Human0.89288276
169SOX2_21211035_ChIP-Seq_LN229_Human0.88978663
170SMAD4_21741376_ChIP-Seq_EPCs_Human0.88877223
171CJUN_26792858_Chip-Seq_BT549_Human0.88583473
172SMAD4_21741376_ChIP-Seq_HESCs_Human0.88193474
173OCT4_18555785_Chip-Seq_ESCs_Mouse0.87619671
174CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87522754
175KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87426738
176STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87410205
177CREB1_26743006_Chip-Seq_LNCaP_Human0.87380084
178CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86941669
179SMAD3_21741376_ChIP-Seq_ESCs_Human0.86736520
180CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86209489
181EP300_21415370_ChIP-Seq_HL-1_Mouse0.85858069
182PHF8_20622854_ChIP-Seq_HELA_Human0.84977195
183CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84404728
184TBX20_22080862_ChIP-Seq_HEART_Mouse0.83313625
185TBX20_22328084_ChIP-Seq_HEART_Mouse0.83313625
186FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82105959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.05527737
2MP0001929_abnormal_gametogenesis5.45589828
3MP0002132_abnormal_respiratory_system5.27145716
4MP0009780_abnormal_chondrocyte_physiolo4.00137249
5MP0008877_abnormal_DNA_methylation3.68381476
6MP0002161_abnormal_fertility/fecundity3.30903076
7MP0005670_abnormal_white_adipose3.24332182
8MP0002210_abnormal_sex_determination3.22705085
9MP0002277_abnormal_respiratory_mucosa2.85351513
10MP0001145_abnormal_male_reproductive2.73760307
11MP0008789_abnormal_olfactory_epithelium2.71945754
12MP0000566_synostosis2.54677449
13MP0002653_abnormal_ependyma_morphology2.36416436
14MP0000653_abnormal_sex_gland2.35893417
15MP0005503_abnormal_tendon_morphology2.16425450
16MP0002168_other_aberrant_phenotype2.09732844
17MP0000678_abnormal_parathyroid_gland2.03196272
18MP0005410_abnormal_fertilization16.6958451
19MP0000383_abnormal_hair_follicle1.86904376
20MP0005083_abnormal_biliary_tract1.75792802
21MP0010678_abnormal_skin_adnexa1.73743426
22MP0005499_abnormal_olfactory_system1.63389255
23MP0005394_taste/olfaction_phenotype1.63389255
24MP0002249_abnormal_larynx_morphology1.59453329
25MP0005623_abnormal_meninges_morphology1.53261042
26MP0003646_muscle_fatigue1.51966760
27MP0005248_abnormal_Harderian_gland1.48828404
28MP0002160_abnormal_reproductive_system1.44159885
29MP0004233_abnormal_muscle_weight1.43974802
30MP0003656_abnormal_erythrocyte_physiolo1.42333368
31MP0005395_other_phenotype1.36083142
32MP0010234_abnormal_vibrissa_follicle1.32945864
33MP0005408_hypopigmentation1.31044128
34MP0010030_abnormal_orbit_morphology1.31009449
35MP0005165_increased_susceptibility_to1.26705717
36MP0002282_abnormal_trachea_morphology1.24563020
37MP0001346_abnormal_lacrimal_gland1.20566889
38MP0000681_abnormal_thyroid_gland1.18893633
39MP0005164_abnormal_response_to1.18674080
40MP0001765_abnormal_ion_homeostasis1.18314942
41MP0003279_aneurysm1.14366419
42MP0009379_abnormal_foot_pigmentation1.13482822
43MP0005275_abnormal_skin_tensile1.13068973
44MP0001879_abnormal_lymphatic_vessel1.11217423
45MP0003941_abnormal_skin_development1.10961926
46MP0008438_abnormal_cutaneous_collagen1.10004028
47MP0005409_darkened_coat_color1.09822646
48MP0001984_abnormal_olfaction1.06794064
49MP0002233_abnormal_nose_morphology1.04082159
50MP0002896_abnormal_bone_mineralization1.03550648
51MP0001299_abnormal_eye_distance/1.01935241
52MP0005023_abnormal_wound_healing1.01109886
53MP0004272_abnormal_basement_membrane0.98190270
54MP0004883_abnormal_blood_vessel0.96040061
55MP0008995_early_reproductive_senescence0.94182543
56MP0003566_abnormal_cell_adhesion0.94143449
57MP0002234_abnormal_pharynx_morphology0.92474664
58MP0010368_abnormal_lymphatic_system0.87323482
59MP0000467_abnormal_esophagus_morphology0.86722166
60MP0003115_abnormal_respiratory_system0.84812132
61MP0009384_cardiac_valve_regurgitation0.84346050
62MP0002108_abnormal_muscle_morphology0.82277075
63MP0003878_abnormal_ear_physiology0.80903564
64MP0005377_hearing/vestibular/ear_phenot0.80903564
65MP0002136_abnormal_kidney_physiology0.79546558
66MP0005365_abnormal_bile_salt0.79493581
67MP0005647_abnormal_sex_gland0.77873967
68MP0002876_abnormal_thyroid_physiology0.77845214
69MP0005508_abnormal_skeleton_morphology0.77797445
70MP0002734_abnormal_mechanical_nocicepti0.76806845
71MP0009046_muscle_twitch0.75735074
72MP0009643_abnormal_urine_homeostasis0.73829555
73MP0003091_abnormal_cell_migration0.73482470
74MP0004264_abnormal_extraembryonic_tissu0.73392876
75MP0005220_abnormal_exocrine_pancreas0.73196586
76MP0003453_abnormal_keratinocyte_physiol0.70738261
77MP0009053_abnormal_anal_canal0.70173253
78MP0005666_abnormal_adipose_tissue0.70162871
79MP0005085_abnormal_gallbladder_physiolo0.69510265
80MP0005389_reproductive_system_phenotype0.68993741
81MP0000049_abnormal_middle_ear0.68729776
82MP0003705_abnormal_hypodermis_morpholog0.67199584
83MP0002116_abnormal_craniofacial_bone0.66307383
84MP0005636_abnormal_mineral_homeostasis0.65911377
85MP0000465_gastrointestinal_hemorrhage0.65485231
86MP0001958_emphysema0.65077611
87MP0002060_abnormal_skin_morphology0.64241441
88MP0010155_abnormal_intestine_physiology0.63723748
89MP0003011_delayed_dark_adaptation0.62867934
90MP0002098_abnormal_vibrissa_morphology0.61307461
91MP0003329_amyloid_beta_deposits0.60568920
92MP0004782_abnormal_surfactant_physiolog0.58847963
93MP0001666_abnormal_nutrient_absorption0.57885249
94MP0000163_abnormal_cartilage_morphology0.57700080
95MP0008058_abnormal_DNA_repair0.56115030
96MP0002735_abnormal_chemical_nociception0.55864610
97MP0005310_abnormal_salivary_gland0.54476149
98MP0009703_decreased_birth_body0.53376909
99MP0000432_abnormal_head_morphology0.52915224
100MP0004036_abnormal_muscle_relaxation0.52848458
101MP0000026_abnormal_inner_ear0.52175478
102MP0003937_abnormal_limbs/digits/tail_de0.51265522
103MP0001324_abnormal_eye_pigmentation0.51216883
104MP0000534_abnormal_ureter_morphology0.50843088
105MP0002736_abnormal_nociception_after0.49930828
106MP0000569_abnormal_digit_pigmentation0.48352165
107MP0001293_anophthalmia0.48069888
108MP0002269_muscular_atrophy0.47026521
109MP0001545_abnormal_hematopoietic_system0.46197323
110MP0005397_hematopoietic_system_phenotyp0.46197323
111MP0001764_abnormal_homeostasis0.44621706
112MP0009115_abnormal_fat_cell0.44332533
113MP0000358_abnormal_cell_content/0.43680479
114MP0003950_abnormal_plasma_membrane0.43300606
115MP0003699_abnormal_female_reproductive0.43288111
116MP0009278_abnormal_bone_marrow0.42564931
117MP0002928_abnormal_bile_duct0.40918404
118MP0003942_abnormal_urinary_system0.38655843
119MP0005253_abnormal_eye_physiology0.38227342
120MP0005551_abnormal_eye_electrophysiolog0.35428861
121MP0002295_abnormal_pulmonary_circulatio0.34990631
122MP0002971_abnormal_brown_adipose0.33466286
123MP0004133_heterotaxia0.32966832
124MP0006036_abnormal_mitochondrial_physio0.32084093
125MP0003633_abnormal_nervous_system0.31540192
126MP0002139_abnormal_hepatobiliary_system0.31356717
127MP0005391_vision/eye_phenotype0.31054606
128MP0000604_amyloidosis0.29762957
129MP0003879_abnormal_hair_cell0.28929188
130MP0001968_abnormal_touch/_nociception0.28108388
131MP0004811_abnormal_neuron_physiology0.27875171
132MP0005375_adipose_tissue_phenotype0.27351246
133MP0003948_abnormal_gas_homeostasis0.27279058
134MP0002909_abnormal_adrenal_gland0.27040433
135MP0008875_abnormal_xenobiotic_pharmacok0.26407069
136MP0008961_abnormal_basal_metabolism0.25712916
137MP0000751_myopathy0.25477842
138MP0003861_abnormal_nervous_system0.24428569
139MP0003631_nervous_system_phenotype0.24396713
140MP0001849_ear_inflammation0.24243238
141MP0002152_abnormal_brain_morphology0.22754698
142MP0004742_abnormal_vestibular_system0.22661529
143MP0004270_analgesia0.22042349
144MP0004019_abnormal_vitamin_homeostasis0.21744117
145MP0002169_no_abnormal_phenotype0.21061560
146MP0002873_normal_phenotype0.20812988
147MP0004130_abnormal_muscle_cell0.19870097
148MP0001730_embryonic_growth_arrest0.19598970
149MP0002092_abnormal_eye_morphology0.19542473
150MP0010094_abnormal_chromosome_stability0.19402704
151MP0003045_fibrosis0.18995307
152MP0001119_abnormal_female_reproductive0.17849832
153MP0001727_abnormal_embryo_implantation0.16557155
154MP0002118_abnormal_lipid_homeostasis0.16067761
155MP0008569_lethality_at_weaning0.15759497
156MP0003111_abnormal_nucleus_morphology0.14771254
157MP0002102_abnormal_ear_morphology0.14695988
158MP0004043_abnormal_pH_regulation0.14577135
159MP0002133_abnormal_respiratory_system0.14505495
160MP0005388_respiratory_system_phenotype0.14505495
161MP0002796_impaired_skin_barrier0.14265521
162MP0010329_abnormal_lipoprotein_level0.14035631
163MP0001270_distended_abdomen0.14015801
164MP0002229_neurodegeneration0.13678026
165MP0003786_premature_aging0.12997494
166MP0003959_abnormal_lean_body0.12864627
167MP0001440_abnormal_grooming_behavior0.12656178
168MP0000001_mammalian_phenotype0.12630075
169MP0004087_abnormal_muscle_fiber0.12419255
170MP0006035_abnormal_mitochondrial_morpho0.12214478
171MP0003787_abnormal_imprinting0.12178043

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.34181143
2Abnormal respiratory motile cilium morphology (HP:0005938)9.34181143
3Abnormal respiratory motile cilium physiology (HP:0012261)9.30942420
4Rhinitis (HP:0012384)7.46419136
5Abnormal ciliary motility (HP:0012262)7.37009758
6Chronic bronchitis (HP:0004469)7.28527069
7Infertility (HP:0000789)7.08748097
8Nasal polyposis (HP:0100582)6.42485009
9Abnormality of the nasal mucosa (HP:0000433)5.35511267
10Male infertility (HP:0003251)5.11549308
11Bronchitis (HP:0012387)4.66112261
12Bronchiectasis (HP:0002110)4.52867809
13Nephronophthisis (HP:0000090)4.16210890
14Abnormal spermatogenesis (HP:0008669)3.72738295
15Occipital encephalocele (HP:0002085)3.64446083
16Atelectasis (HP:0100750)3.36360869
17Recurrent otitis media (HP:0000403)3.29618614
18Recurrent sinusitis (HP:0011108)3.17146752
19Abnormality of the renal medulla (HP:0100957)3.14666528
20True hermaphroditism (HP:0010459)3.06682591
21Tubulointerstitial nephritis (HP:0001970)2.92840507
22Recurrent bronchitis (HP:0002837)2.91169055
23Impulsivity (HP:0100710)2.80933082
24Hyperactive renin-angiotensin system (HP:0000841)2.80173411
25Tubular atrophy (HP:0000092)2.69305097
26Chronic otitis media (HP:0000389)2.68573760
27Cholecystitis (HP:0001082)2.61186702
28Abnormal gallbladder physiology (HP:0012438)2.61186702
29Chronic hepatic failure (HP:0100626)2.55956621
30Tubulointerstitial abnormality (HP:0001969)2.53907061
31Pancreatic cysts (HP:0001737)2.48346423
32Abnormality of midbrain morphology (HP:0002418)2.46945856
33Molar tooth sign on MRI (HP:0002419)2.46945856
34Gonadotropin excess (HP:0000837)2.28674174
35Dyschromatopsia (HP:0007641)2.27083400
36Absent frontal sinuses (HP:0002688)2.25835241
37Azoospermia (HP:0000027)2.22279831
38Medial flaring of the eyebrow (HP:0010747)2.20458907
39Choroideremia (HP:0001139)2.15954382
40Tubulointerstitial fibrosis (HP:0005576)2.15099383
41Spastic tetraparesis (HP:0001285)2.03974466
42Absent/shortened dynein arms (HP:0200106)13.3972815
43Dynein arm defect of respiratory motile cilia (HP:0012255)13.3972815
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8228184
45Decreased central vision (HP:0007663)1.99410059
46Aplasia/Hypoplasia of the tongue (HP:0010295)1.87110779
47Hemorrhage of the eye (HP:0011885)1.82627324
48Heterotopia (HP:0002282)1.81826204
49Neurofibrillary tangles (HP:0002185)1.81127387
50Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.79854443
51Anencephaly (HP:0002323)1.78829154
52Stage 5 chronic kidney disease (HP:0003774)1.78289612
53Polydipsia (HP:0001959)1.74919006
54Abnormal drinking behavior (HP:0030082)1.74919006
55Postaxial foot polydactyly (HP:0001830)1.74459901
56Bell-shaped thorax (HP:0001591)1.72597966
57Male pseudohermaphroditism (HP:0000037)1.72149041
58Bile duct proliferation (HP:0001408)1.70780944
59Abnormal biliary tract physiology (HP:0012439)1.70780944
60Congenital hepatic fibrosis (HP:0002612)1.65835826
61Renal salt wasting (HP:0000127)1.65055463
62Abnormality of renal excretion (HP:0011036)1.64063287
63Double outlet right ventricle (HP:0001719)1.60990706
64Congenital malformation of the right heart (HP:0011723)1.60990706
65Abnormality of the renal cortex (HP:0011035)1.57584361
66Decreased electroretinogram (ERG) amplitude (HP:0000654)1.57135983
67Short ribs (HP:0000773)1.56254966
68Abnormality of dentin (HP:0010299)1.56164693
69Decreased circulating renin level (HP:0003351)1.55508840
70Short nail (HP:0001799)1.54303950
71Hypoplasia of the capital femoral epiphysis (HP:0003090)1.54227816
72Asymmetric septal hypertrophy (HP:0001670)1.52740502
73Congenital primary aphakia (HP:0007707)1.51817620
74Sclerocornea (HP:0000647)1.50695798
75Cerebral inclusion bodies (HP:0100314)1.50075865
76Bundle branch block (HP:0011710)1.49754454
77Oculomotor apraxia (HP:0000657)1.46600415
78Furrowed tongue (HP:0000221)1.46314328
79Abnormality of the frontal sinuses (HP:0002687)1.45129717
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.44072047
81Asplenia (HP:0001746)1.43774627
82Abnormality of permanent molar morphology (HP:0011071)1.43537969
83Abnormality of the dental root (HP:0006486)1.43537969
84Taurodontia (HP:0000679)1.43537969
85Aplasia/Hypoplasia of the lens (HP:0008063)1.43160565
86Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.41598310
87Renal dysplasia (HP:0000110)1.39309904
88Abnormal urine output (HP:0012590)1.38994712
89Hemiparesis (HP:0001269)1.38695499
90Cone-rod dystrophy (HP:0000548)1.38370388
91Abnormality of the dental pulp (HP:0006479)1.37254528
92Glucose intolerance (HP:0000833)1.37234906
93Postaxial hand polydactyly (HP:0001162)1.37063731
94Hyperaldosteronism (HP:0000859)1.36992458
95Chronic sinusitis (HP:0011109)1.36887704
96Hand muscle atrophy (HP:0009130)1.36565339
97Cystic liver disease (HP:0006706)1.36150395
98Deformed sella turcica (HP:0002681)1.33463188
99Abnormality of molar (HP:0011077)1.32683070
100Abnormality of molar morphology (HP:0011070)1.32683070
101Easy fatigability (HP:0003388)1.32505802
102Facial cleft (HP:0002006)1.32193250
103Hypercholesterolemia (HP:0003124)1.31880757
104Abnormality of chloride homeostasis (HP:0011422)1.31877179
105Exercise-induced myalgia (HP:0003738)1.31710288
106Fibular hypoplasia (HP:0003038)1.31261105
107Abnormality of the distal phalanges of the toes (HP:0010182)1.28615330
108Sensory axonal neuropathy (HP:0003390)1.27790366
109Nephrogenic diabetes insipidus (HP:0009806)1.27784386
110Loss of speech (HP:0002371)1.27511133
111Myoglobinuria (HP:0002913)1.27458908
112Broad distal phalanx of finger (HP:0009836)1.25449308
113Constricted visual fields (HP:0001133)1.24979431
114Abnormality of the lower motor neuron (HP:0002366)1.24038580
115Median cleft lip (HP:0000161)1.23314224
116Truncal obesity (HP:0001956)1.22524960
117Absent epiphyses (HP:0010577)1.21814345
118Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.21814345
119Neoplasm of the heart (HP:0100544)1.19351185
120Fatigable weakness (HP:0003473)1.18245314
121Abnormality of the neuromuscular junction (HP:0003398)1.18245314
122Nephropathy (HP:0000112)1.17607152
123Hyponatremia (HP:0002902)1.16039501
124Abnormality of renin-angiotensin system (HP:0000847)1.15538278
125Hyperkalemia (HP:0002153)1.15359721
126Hyporeflexia of lower limbs (HP:0002600)1.15210341
127Cerebellar dysplasia (HP:0007033)1.14529526
128Pancreatic fibrosis (HP:0100732)1.14345182
129Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.12906918
130Short thorax (HP:0010306)1.12298709
131Short femoral neck (HP:0100864)1.11876095
132Gait imbalance (HP:0002141)1.11379542
133Flat acetabular roof (HP:0003180)1.11217686
134Preaxial hand polydactyly (HP:0001177)1.10963209
135Hypokalemic alkalosis (HP:0001949)1.09936691
136Bifid scrotum (HP:0000048)1.09375303
137Aplasia of the musculature (HP:0100854)1.07509196
138Abnormality of monocarboxylic acid metabolism (HP:0010996)1.07141270
139Abnormality of macular pigmentation (HP:0008002)1.07042866
140Vaginal atresia (HP:0000148)1.06716855
141Genital tract atresia (HP:0001827)1.06182391
142Poor coordination (HP:0002370)1.05946753
143Vascular calcification (HP:0004934)1.05529183
144Popliteal pterygium (HP:0009756)1.04898803
145Obstructive sleep apnea (HP:0002870)1.04887542
146Cardiovascular calcification (HP:0011915)1.04507997
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.03972593
148Distal upper limb amyotrophy (HP:0007149)1.03343344
149Upper limb amyotrophy (HP:0009129)1.03343344
150Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.01270386
151Spinal cord compression (HP:0002176)1.01184805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.57245670
2PDK47.57245670
3TESK16.93784102
4PRKD35.89384687
5ICK4.88274468
6PDK24.88211218
7MST44.82125254
8EPHA24.75809277
9STK242.32971333
10PTK2B2.32112165
11MAP3K22.24101518
12WNK42.16335064
13MAPKAPK32.11691821
14PNCK2.10100281
15SMG12.04484675
16STK392.02298064
17STK381.96146277
18DYRK1B1.83416250
19NME11.60944934
20MAP3K31.54913553
21MST1R1.51492304
22NEK21.47746890
23BCR1.41432593
24TRPM71.25369972
25PDK11.22528363
26DDR21.15792074
27MAPK151.04219850
28MYLK1.03140922
29LATS10.96569795
30TYRO30.94402876
31NEK90.92751628
32MAP3K70.91950184
33LRRK20.87776420
34DYRK30.85817800
35WNK10.84971478
36PDPK10.83934082
37PRKCI0.81814217
38RIPK40.75795579
39IRAK10.74047865
40EEF2K0.70491241
41CAMK1G0.69325360
42TBK10.69160043
43EPHA30.67802871
44MET0.67050072
45CCNB10.64077076
46ERBB20.61628891
47FER0.60924966
48ERBB30.60877749
49TESK20.60761795
50STK30.59577080
51PASK0.58918904
52LMTK20.58566990
53MAP3K120.56469251
54MAP2K60.55412249
55PINK10.54513890
56FGFR30.53917923
57RPS6KA20.53402841
58CDC42BPA0.53038535
59TTK0.51924072
60CHEK20.50761869
61PRKAA20.50407214
62NTRK20.49750196
63INSRR0.49487968
64ROCK10.49063575
65ROCK20.48683622
66PAK10.44651240
67TLK10.40747912
68CAMK2G0.40577305
69PTK20.40399999
70LATS20.40181208
71IRAK20.38885403
72PAK40.38294108
73MUSK0.38017640
74PAK20.37586708
75NTRK10.37251692
76PRKCG0.36763591
77AURKA0.36158405
78STK38L0.36110239
79CHEK10.32552128
80SGK10.30822938
81MARK20.30761669
82GRK10.30626464
83MTOR0.29803942
84MAP3K100.29520204
85NLK0.28265697
86HIPK20.26612614
87MAPKAPK50.26356813
88FGFR40.26190200
89TIE10.25957654
90CAMKK10.25337220
91NEK60.24980865
92ATM0.23083076
93BRD40.22766350
94PIM20.22607118
95PRKCZ0.21293400
96PRKD20.20436195
97PRKAA10.19564351
98AKT20.19331331
99ADRBK10.19251424
100ABL20.19231703
101PTK60.19202741
102GRK60.19047518
103ABL10.19037502
104RET0.17599128
105ERBB40.17301536
106RPS6KB20.16255388
107AKT30.16229835
108MAP2K20.15881426
109ATR0.15542906
110PRKCQ0.15468301
111PRKACA0.14512484
112MAP2K10.14413364
113CDK150.13714864
114PLK40.13248236
115MAP3K80.12493827
116CDK180.11092963
117RPS6KB10.11091448
118STK100.11064077
119BRSK20.10854856
120EPHB10.10797359
121PRKG20.10540249
122CDK11A0.09616648
123CDK60.09384109
124RPS6KA10.09015934
125TRIB30.08663384
126WEE10.08554878
127GSK3B0.07525735
128CDK140.06505959
129BRSK10.06186329
130STK110.04616644
131PLK10.04518272
132CSNK2A10.04326267
133CAMK2A0.04047506
134CSNK1D0.03791239
135PRKCD0.03141380
136CSF1R0.03045805
137PRKG10.02503095
138PRKACG0.02324377
139EGFR0.02127007
140RIPK10.01992981
141MAPK80.01701808
142PDGFRB0.01510621
143PKN10.01320124
144PRKCB0.01307932
145PAK60.01218999
146CLK10.00878793
147CDK120.00842253
148PRKCA0.00800216
149MAP3K10.00782263
150MARK30.00751039
151CDK10.00022622
152CDK4-0.0263174
153CSK-0.0258405
154BRAF-0.0249364
155PRKACB-0.0238697
156PIM1-0.0223676
157SRC-0.0222357
158RPS6KA3-0.0203956
159CSNK2A2-0.0158639
160ZAP70-0.0104529
161CDK2-0.0019021

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.97513562
2Phenylalanine metabolism_Homo sapiens_hsa003604.89522569
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.41285999
4Histidine metabolism_Homo sapiens_hsa003404.29048357
5Tyrosine metabolism_Homo sapiens_hsa003503.80337310
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.16838797
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.04877491
8Pyruvate metabolism_Homo sapiens_hsa006203.02932594
9Linoleic acid metabolism_Homo sapiens_hsa005913.01187786
10Vitamin B6 metabolism_Homo sapiens_hsa007502.89610887
11beta-Alanine metabolism_Homo sapiens_hsa004102.72585174
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.61498097
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.53501659
14Glucagon signaling pathway_Homo sapiens_hsa049222.40569686
15Propanoate metabolism_Homo sapiens_hsa006402.31041509
16Retinol metabolism_Homo sapiens_hsa008302.20546145
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.09832533
18Caffeine metabolism_Homo sapiens_hsa002322.01581059
19PPAR signaling pathway_Homo sapiens_hsa033202.00498705
20Glycerolipid metabolism_Homo sapiens_hsa005611.98755565
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.93184124
22Basal transcription factors_Homo sapiens_hsa030221.84631678
23Selenocompound metabolism_Homo sapiens_hsa004501.79575849
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.76999178
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.75406607
26Sphingolipid metabolism_Homo sapiens_hsa006001.71203555
27Mineral absorption_Homo sapiens_hsa049781.70043290
28Fructose and mannose metabolism_Homo sapiens_hsa000511.68442628
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65737424
30Fatty acid degradation_Homo sapiens_hsa000711.60739513
31Tight junction_Homo sapiens_hsa045301.59158360
32Fatty acid metabolism_Homo sapiens_hsa012121.56881068
33Dorso-ventral axis formation_Homo sapiens_hsa043201.55957891
34Fat digestion and absorption_Homo sapiens_hsa049751.48252721
35Oocyte meiosis_Homo sapiens_hsa041141.45183139
36Ether lipid metabolism_Homo sapiens_hsa005651.42946130
37Amphetamine addiction_Homo sapiens_hsa050311.42386825
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38874944
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.38643908
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38313630
41Pentose phosphate pathway_Homo sapiens_hsa000301.31113732
42Cardiac muscle contraction_Homo sapiens_hsa042601.29054715
43Carbon metabolism_Homo sapiens_hsa012001.27441175
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.26793946
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14943232
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14910127
47Antigen processing and presentation_Homo sapiens_hsa046121.12259471
48Renin secretion_Homo sapiens_hsa049241.09837207
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09766925
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09061123
51Glutathione metabolism_Homo sapiens_hsa004801.06637452
52Complement and coagulation cascades_Homo sapiens_hsa046101.06622111
53Hedgehog signaling pathway_Homo sapiens_hsa043401.05328600
54ECM-receptor interaction_Homo sapiens_hsa045121.03780157
55Adherens junction_Homo sapiens_hsa045201.03058621
56Starch and sucrose metabolism_Homo sapiens_hsa005001.03035068
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.96492913
58Circadian rhythm_Homo sapiens_hsa047100.94137635
59Insulin secretion_Homo sapiens_hsa049110.92180754
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.91696905
61Arachidonic acid metabolism_Homo sapiens_hsa005900.90585272
62Chemical carcinogenesis_Homo sapiens_hsa052040.90159172
63Thyroid hormone synthesis_Homo sapiens_hsa049180.88898238
64Collecting duct acid secretion_Homo sapiens_hsa049660.88728778
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88523069
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88470023
67Bile secretion_Homo sapiens_hsa049760.88062251
68Huntingtons disease_Homo sapiens_hsa050160.87649489
69Purine metabolism_Homo sapiens_hsa002300.87448658
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85747041
71Notch signaling pathway_Homo sapiens_hsa043300.84252209
72Estrogen signaling pathway_Homo sapiens_hsa049150.83786376
73Peroxisome_Homo sapiens_hsa041460.82756897
74Fanconi anemia pathway_Homo sapiens_hsa034600.82416453
75mRNA surveillance pathway_Homo sapiens_hsa030150.82272952
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.79678353
77Amoebiasis_Homo sapiens_hsa051460.75070355
78Choline metabolism in cancer_Homo sapiens_hsa052310.74517465
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73669398
80Biosynthesis of amino acids_Homo sapiens_hsa012300.72199498
81Salivary secretion_Homo sapiens_hsa049700.71245818
82Long-term potentiation_Homo sapiens_hsa047200.69780435
83Pancreatic secretion_Homo sapiens_hsa049720.62830979
84ABC transporters_Homo sapiens_hsa020100.61394432
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61284873
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61237658
87Protein digestion and absorption_Homo sapiens_hsa049740.61232265
88Hepatitis C_Homo sapiens_hsa051600.60803150
89Legionellosis_Homo sapiens_hsa051340.60385251
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.60043082
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.59099018
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.59095041
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58954725
94Renin-angiotensin system_Homo sapiens_hsa046140.58499840
95Gastric acid secretion_Homo sapiens_hsa049710.58412646
96Olfactory transduction_Homo sapiens_hsa047400.57817251
97RNA transport_Homo sapiens_hsa030130.56901506
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.53139583
99Calcium signaling pathway_Homo sapiens_hsa040200.52063552
100Endocytosis_Homo sapiens_hsa041440.51618038
101Synaptic vesicle cycle_Homo sapiens_hsa047210.48355753
102Arginine and proline metabolism_Homo sapiens_hsa003300.47138636
103AMPK signaling pathway_Homo sapiens_hsa041520.46798553
104Hippo signaling pathway_Homo sapiens_hsa043900.46129185
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45051181
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44951431
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44658028
108Focal adhesion_Homo sapiens_hsa045100.43961102
109Taste transduction_Homo sapiens_hsa047420.43636109
110Lysosome_Homo sapiens_hsa041420.42599311
111Dilated cardiomyopathy_Homo sapiens_hsa054140.41041100
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39761805
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39191558
114cAMP signaling pathway_Homo sapiens_hsa040240.38775572
115Sulfur metabolism_Homo sapiens_hsa009200.38205727
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37426325
117Proteoglycans in cancer_Homo sapiens_hsa052050.37102932
118Inositol phosphate metabolism_Homo sapiens_hsa005620.36881409
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36262628
120Systemic lupus erythematosus_Homo sapiens_hsa053220.35334894
121Circadian entrainment_Homo sapiens_hsa047130.33714168
122Prostate cancer_Homo sapiens_hsa052150.33012588
123VEGF signaling pathway_Homo sapiens_hsa043700.32779219
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31965731
125Metabolic pathways_Homo sapiens_hsa011000.30524838
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29056526
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.26803967
128Cocaine addiction_Homo sapiens_hsa050300.24778555
129Axon guidance_Homo sapiens_hsa043600.23074395
130Melanogenesis_Homo sapiens_hsa049160.22580429
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22026639
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21418340
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20825948
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20230963
135Hematopoietic cell lineage_Homo sapiens_hsa046400.20181430
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.17796852
137Alcoholism_Homo sapiens_hsa050340.17604122
138Basal cell carcinoma_Homo sapiens_hsa052170.17560530
139Arginine biosynthesis_Homo sapiens_hsa002200.16591364
140N-Glycan biosynthesis_Homo sapiens_hsa005100.15432843
141Vitamin digestion and absorption_Homo sapiens_hsa049770.15182330
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14705239
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14379233
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13735988
145Serotonergic synapse_Homo sapiens_hsa047260.13642645
146Phagosome_Homo sapiens_hsa041450.13460286
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.13252177
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13164308
149Vibrio cholerae infection_Homo sapiens_hsa051100.12462339
150Cyanoamino acid metabolism_Homo sapiens_hsa004600.12284155
151HIF-1 signaling pathway_Homo sapiens_hsa040660.11484949
152Type II diabetes mellitus_Homo sapiens_hsa049300.11357939
153p53 signaling pathway_Homo sapiens_hsa041150.11223516
154Pyrimidine metabolism_Homo sapiens_hsa002400.10611431
155Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.10054474
156Wnt signaling pathway_Homo sapiens_hsa043100.10030555
157Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09468584
158Insulin resistance_Homo sapiens_hsa049310.09021287
159Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.08879123
160Salmonella infection_Homo sapiens_hsa051320.08858203

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