SPATA19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.88400034
2plasma membrane fusion (GO:0045026)9.81589854
3axonemal dynein complex assembly (GO:0070286)9.53952480
4motile cilium assembly (GO:0044458)9.38087968
5reproduction (GO:0000003)9.27253712
6regulation of cilium movement (GO:0003352)8.67158992
7cilium or flagellum-dependent cell motility (GO:0001539)7.94787155
8cilium movement (GO:0003341)7.88386831
9negative regulation of inclusion body assembly (GO:0090084)7.67955835
10sperm capacitation (GO:0048240)7.31666139
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.26625132
12single fertilization (GO:0007338)7.26563955
13synaptonemal complex organization (GO:0070193)7.06605727
14synaptonemal complex assembly (GO:0007130)6.98207181
15piRNA metabolic process (GO:0034587)6.92631115
16organic cation transport (GO:0015695)6.90320141
17* spermatogenesis (GO:0007283)6.89095819
18* male gamete generation (GO:0048232)6.86550174
19male meiosis (GO:0007140)6.70748334
20microtubule depolymerization (GO:0007019)6.69260743
21regulation of inclusion body assembly (GO:0090083)6.34809069
22* gamete generation (GO:0007276)6.30646451
23fertilization (GO:0009566)6.20349690
24calcium ion-dependent exocytosis (GO:0017156)5.77091039
25chromosome condensation (GO:0030261)5.76765754
26germ cell development (GO:0007281)5.52345060
27DNA packaging (GO:0006323)5.43423908
28cellular process involved in reproduction in multicellular organism (GO:0022412)5.37903387
29glycerol ether metabolic process (GO:0006662)5.36107192
30spermatid nucleus differentiation (GO:0007289)5.31897763
31regulation of microtubule-based movement (GO:0060632)5.10074569
32cell recognition (GO:0008037)5.09959222
33microtubule severing (GO:0051013)5.02649193
34* multicellular organismal reproductive process (GO:0048609)4.97914554
35sexual reproduction (GO:0019953)4.96918734
36ventricular system development (GO:0021591)4.96383152
37ether metabolic process (GO:0018904)4.95545003
38seminiferous tubule development (GO:0072520)4.70754577
39chromosome organization involved in meiosis (GO:0070192)4.66990279
40single strand break repair (GO:0000012)4.60268872
41male meiosis I (GO:0007141)4.53952370
42DNA methylation involved in gamete generation (GO:0043046)4.46219107
43chaperone-mediated protein complex assembly (GO:0051131)4.28498949
44left/right pattern formation (GO:0060972)4.24984040
45meiotic nuclear division (GO:0007126)3.98286304
46* multicellular organismal development (GO:0007275)3.97232723
47sequestering of actin monomers (GO:0042989)3.84769980
48protein K11-linked deubiquitination (GO:0035871)3.67920657
49meiosis I (GO:0007127)3.61159547
50genitalia morphogenesis (GO:0035112)3.54329872
51microtubule polymerization or depolymerization (GO:0031109)3.51723023
52protein polyglutamylation (GO:0018095)3.47807576
53protein refolding (GO:0042026)3.40556949
54meiotic cell cycle (GO:0051321)3.33563270
55regulation of spindle checkpoint (GO:0090231)3.30704252
56glycolytic process (GO:0006096)3.29460929
57polyol catabolic process (GO:0046174)3.16254510
58alditol metabolic process (GO:0019400)3.08244608
59nucleus organization (GO:0006997)3.07659311
60nucleoside diphosphate phosphorylation (GO:0006165)3.06828344
61protein localization to cilium (GO:0061512)3.06550448
62interferon-gamma secretion (GO:0072643)3.06182564
63mitotic sister chromatid cohesion (GO:0007064)3.01904774
64polyamine biosynthetic process (GO:0006596)3.00072278
65amino-acid betaine transport (GO:0015838)2.99876054
66carnitine transport (GO:0015879)2.99876054
67positive regulation of macrophage activation (GO:0043032)2.99841133
68monoubiquitinated protein deubiquitination (GO:0035520)2.97766870
69chromatin silencing (GO:0006342)2.89532434
70GTP biosynthetic process (GO:0006183)2.84664746
71carnitine transmembrane transport (GO:1902603)2.80305640
72RNA localization (GO:0006403)2.80196715
73RNA destabilization (GO:0050779)2.79177319
74regulation of cilium assembly (GO:1902017)2.76740115
75cilium organization (GO:0044782)2.70291197
76meiotic cell cycle process (GO:1903046)2.67971161
77microtubule-based movement (GO:0007018)2.63002186
78synapsis (GO:0007129)2.62043714
79cilium assembly (GO:0042384)2.59951013
80cellular component assembly involved in morphogenesis (GO:0010927)2.59638838
81mitochondrion degradation (GO:0000422)2.59169896
82glycerol metabolic process (GO:0006071)2.58057427
83cilium morphogenesis (GO:0060271)2.54745275
84axoneme assembly (GO:0035082)2.53806168
85UTP biosynthetic process (GO:0006228)2.53331967
86positive regulation of glycolytic process (GO:0045821)2.51667616
87lactate metabolic process (GO:0006089)2.43798899
88membrane protein intracellular domain proteolysis (GO:0031293)2.43498153
89peptidyl-glutamic acid modification (GO:0018200)2.43067439
90sperm motility (GO:0030317)14.6625031
91cell wall macromolecule metabolic process (GO:0044036)13.1533384
92cell wall macromolecule catabolic process (GO:0016998)13.1533384
93fusion of sperm to egg plasma membrane (GO:0007342)12.8868496
94acrosome reaction (GO:0007340)12.6209754
95acrosome assembly (GO:0001675)11.6315564
96sperm-egg recognition (GO:0035036)11.5885191
97binding of sperm to zona pellucida (GO:0007339)10.7009330
98multicellular organism reproduction (GO:0032504)10.5020656
99cell-cell recognition (GO:0009988)10.4137493
100spermatid development (GO:0007286)10.0293889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.96355958
2EZH2_22144423_ChIP-Seq_EOC_Human4.31810403
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.01101132
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.16513711
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.99158851
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.64867018
7VDR_22108803_ChIP-Seq_LS180_Human2.59809911
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.54251259
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.19844557
10EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.18487026
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.15086889
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05999179
13ZNF274_21170338_ChIP-Seq_K562_Hela2.05494302
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.95406296
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87566642
16KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.81799060
17STAT1_17558387_ChIP-Seq_HELA_Human1.77206432
18ELK4_26923725_Chip-Seq_MESODERM_Mouse1.74606435
19FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74054128
20SOX2_22085726_ChIP-Seq_NPCs_Mouse1.66886090
21TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.65646760
22* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63373584
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61782076
24GATA3_21867929_ChIP-Seq_CD8_Mouse1.58370209
25GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50983209
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.50264053
27FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48167249
28KDM2B_26808549_Chip-Seq_REH_Human1.47851453
29PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45744247
30RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45490962
31CBP_20019798_ChIP-Seq_JUKART_Human1.42821928
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42821928
33P53_21459846_ChIP-Seq_SAOS-2_Human1.40513646
34TAL1_26923725_Chip-Seq_HPCs_Mouse1.39763779
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38419846
36KAP1_22055183_ChIP-Seq_ESCs_Mouse1.34897781
37LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33266491
38* REST_21632747_ChIP-Seq_MESCs_Mouse1.32039818
39GATA3_21867929_ChIP-Seq_TH1_Mouse1.29116913
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27140655
41SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26931419
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.26715213
43RAD21_21589869_ChIP-Seq_MESCs_Mouse1.24732719
44CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21152061
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21087213
46CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21035179
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20886035
48SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19259036
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.19162711
50FLI1_21867929_ChIP-Seq_TH2_Mouse1.18694497
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17251152
52ERG_20517297_ChIP-Seq_VCAP_Human1.16794887
53SPI1_26923725_Chip-Seq_HPCs_Mouse1.15215753
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14616410
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14616410
56* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13395118
57MYC_27129775_Chip-Seq_CORNEA_Mouse1.13085401
58RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12469340
59* GF1_26923725_Chip-Seq_HPCs_Mouse1.11687121
60SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11262906
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09101649
62GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07766621
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07637014
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07487982
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07191391
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.06721882
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05717573
68TAF15_26573619_Chip-Seq_HEK293_Human1.05311668
69ESET_19884257_ChIP-Seq_ESCs_Mouse1.05057645
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04756503
71RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04500244
72EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03457491
73* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03191484
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.02691979
75RARA_24833708_ChIP-Seq_LIVER_Mouse1.02252861
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.01858194
77PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01743271
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01529624
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01228075
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.00693382
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98833932
82CTCF_20526341_ChIP-Seq_ESCs_Human0.98320591
83SOX11_22085726_ChIP-Seq_ESNs_Mouse0.97198139
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97138311
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96758596
86* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96648998
87LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94423688
88OCT4_18555785_Chip-Seq_ESCs_Mouse0.93496900
89ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92910289
90P53_22387025_ChIP-Seq_ESCs_Mouse0.91747528
91BCOR_27268052_Chip-Seq_Bcells_Human0.90835850
92SOX9_26525672_Chip-Seq_HEART_Mouse0.90123527
93FLI1_21867929_ChIP-Seq_CD8_Mouse0.89649565
94KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89358124
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88909748
96CMYC_18555785_Chip-Seq_ESCs_Mouse0.88447030
97SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88112591
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87778645
99STAT3_18555785_ChIP-Seq_MESCs_Mouse0.86730434
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.86585503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.11248850
2MP0001929_abnormal_gametogenesis5.55878004
3MP0008877_abnormal_DNA_methylation3.76058852
4MP0002161_abnormal_fertility/fecundity3.33490823
5MP0002210_abnormal_sex_determination3.29443731
6MP0005670_abnormal_white_adipose3.01263690
7MP0001145_abnormal_male_reproductive2.78038171
8MP0000653_abnormal_sex_gland2.39125587
9MP0005410_abnormal_fertilization16.8466010
10MP0002653_abnormal_ependyma_morphology1.96979706
11MP0003646_muscle_fatigue1.39600702
12MP0002160_abnormal_reproductive_system1.38014510
13MP0004233_abnormal_muscle_weight1.35605702
14MP0002282_abnormal_trachea_morphology1.15216262
15MP0005623_abnormal_meninges_morphology1.13530673
16MP0001765_abnormal_ion_homeostasis1.08341109
17MP0005647_abnormal_sex_gland1.01774456
18MP0001984_abnormal_olfaction0.95303118
19MP0002234_abnormal_pharynx_morphology0.89585739
20MP0008058_abnormal_DNA_repair0.77608252
21MP0005389_reproductive_system_phenotype0.67713212
22MP0009046_muscle_twitch0.64539731
23MP0003115_abnormal_respiratory_system0.64377222
24MP0003878_abnormal_ear_physiology0.62353506
25MP0005377_hearing/vestibular/ear_phenot0.62353506
26MP0005636_abnormal_mineral_homeostasis0.61534098
27MP0002736_abnormal_nociception_after0.61167768
28MP0008995_early_reproductive_senescence0.60911072
29MP0001764_abnormal_homeostasis0.60385828
30MP0003011_delayed_dark_adaptation0.59344073
31MP0003329_amyloid_beta_deposits0.58945991
32MP0005666_abnormal_adipose_tissue0.58038162
33MP0004036_abnormal_muscle_relaxation0.51719922
34MP0002269_muscular_atrophy0.47261729
35MP0003959_abnormal_lean_body0.44771375
36MP0001348_abnormal_lacrimal_gland0.44117754
37MP0001324_abnormal_eye_pigmentation0.43565508
38MP0000534_abnormal_ureter_morphology0.42962993
39MP0009115_abnormal_fat_cell0.42856980
40MP0003699_abnormal_female_reproductive0.42829910
41MP0000358_abnormal_cell_content/0.41719051
42MP0005397_hematopoietic_system_phenotyp0.39003084
43MP0001545_abnormal_hematopoietic_system0.39003084
44MP0009278_abnormal_bone_marrow0.38111452
45MP0000569_abnormal_digit_pigmentation0.37706610
46MP0000604_amyloidosis0.36748539
47MP0006036_abnormal_mitochondrial_physio0.36577077
48MP0002971_abnormal_brown_adipose0.35825915
49MP0001968_abnormal_touch/_nociception0.35223976
50MP0002928_abnormal_bile_duct0.35014716
51MP0001293_anophthalmia0.34431598
52MP0005253_abnormal_eye_physiology0.34135872
53MP0010094_abnormal_chromosome_stability0.33937134
54MP0005551_abnormal_eye_electrophysiolog0.33035577
55MP0004270_analgesia0.30735109
56MP0004811_abnormal_neuron_physiology0.30283946
57MP0004742_abnormal_vestibular_system0.30162844
58MP0002254_reproductive_system_inflammat0.29151622
59MP0003633_abnormal_nervous_system0.28300749
60MP0003942_abnormal_urinary_system0.26785921
61MP0004133_heterotaxia0.26341067
62MP0003948_abnormal_gas_homeostasis0.25809849
63MP0002169_no_abnormal_phenotype0.25529346
64MP0002873_normal_phenotype0.25361181
65MP0005375_adipose_tissue_phenotype0.24945803
66MP0009697_abnormal_copulation0.23859258
67MP0002139_abnormal_hepatobiliary_system0.23776570
68MP0002295_abnormal_pulmonary_circulatio0.23194706
69MP0005391_vision/eye_phenotype0.23085098
70MP0003631_nervous_system_phenotype0.23073042
71MP0001730_embryonic_growth_arrest0.22506520
72MP0001119_abnormal_female_reproductive0.21677900
73MP0002152_abnormal_brain_morphology0.21226434
74MP0003879_abnormal_hair_cell0.20761934
75MP0002909_abnormal_adrenal_gland0.20503207
76MP0003861_abnormal_nervous_system0.20022508
77MP0002693_abnormal_pancreas_physiology0.18693055
78MP0003111_abnormal_nucleus_morphology0.18061696
79MP0004019_abnormal_vitamin_homeostasis0.18015986
80MP0002405_respiratory_system_inflammati0.16809668
81MP0003183_abnormal_peptide_metabolism0.16525464
82MP0003950_abnormal_plasma_membrane0.16459927
83MP0002876_abnormal_thyroid_physiology0.16327387
84MP0004145_abnormal_muscle_electrophysio0.16299335
85MP0001440_abnormal_grooming_behavior0.15243007
86MP0001986_abnormal_taste_sensitivity0.14748179
87MP0002272_abnormal_nervous_system0.14514389
88MP0010307_abnormal_tumor_latency0.14394750
89MP0006035_abnormal_mitochondrial_morpho0.14270270
90MP0000001_mammalian_phenotype0.14004469
91MP0002229_neurodegeneration0.13715130
92MP0008569_lethality_at_weaning0.13443350
93MP0005423_abnormal_somatic_nervous0.13318450
94MP0002118_abnormal_lipid_homeostasis0.13275210
95MP0001849_ear_inflammation0.12411880
96MP0004043_abnormal_pH_regulation0.12114910
97MP0005319_abnormal_enzyme/_coenzyme0.12107308
98MP0000920_abnormal_myelination0.11842882
99MP0002822_catalepsy0.10941010
100MP0001873_stomach_inflammation0.10656391

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.34876672
2Abnormal respiratory motile cilium morphology (HP:0005938)9.33930470
3Abnormal respiratory epithelium morphology (HP:0012253)9.33930470
4Chronic bronchitis (HP:0004469)7.45292249
5Rhinitis (HP:0012384)7.38304472
6Abnormal ciliary motility (HP:0012262)7.29408579
7Infertility (HP:0000789)7.15813636
8Nasal polyposis (HP:0100582)6.35564238
9Abnormality of the nasal mucosa (HP:0000433)5.22135941
10Male infertility (HP:0003251)4.94840778
11Bronchitis (HP:0012387)4.58630341
12Bronchiectasis (HP:0002110)4.32760808
13Nephronophthisis (HP:0000090)3.93449138
14Abnormal spermatogenesis (HP:0008669)3.58234127
15Recurrent sinusitis (HP:0011108)3.25689892
16Recurrent otitis media (HP:0000403)3.24054711
17Abnormality of the renal medulla (HP:0100957)2.94011253
18Congenital malformation of the right heart (HP:0011723)2.76197951
19Double outlet right ventricle (HP:0001719)2.76197951
20Tubulointerstitial nephritis (HP:0001970)2.71955235
21Recurrent bronchitis (HP:0002837)2.67522402
22Impulsivity (HP:0100710)2.58485748
23Cholecystitis (HP:0001082)2.50118648
24Abnormal gallbladder physiology (HP:0012438)2.50118648
25Abnormality of midbrain morphology (HP:0002418)2.45496480
26Molar tooth sign on MRI (HP:0002419)2.45496480
27Tubular atrophy (HP:0000092)2.44723814
28Gonadotropin excess (HP:0000837)2.33925958
29Tubulointerstitial abnormality (HP:0001969)2.30947328
30Medial flaring of the eyebrow (HP:0010747)2.29029797
31Dyschromatopsia (HP:0007641)2.23181392
32Azoospermia (HP:0000027)2.11692908
33Choroideremia (HP:0001139)2.04287872
34Absent/shortened dynein arms (HP:0200106)13.6408270
35Dynein arm defect of respiratory motile cilia (HP:0012255)13.6408270
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9605831
37Decreased central vision (HP:0007663)1.95582513
38Spastic tetraparesis (HP:0001285)1.94570132
39Tubulointerstitial fibrosis (HP:0005576)1.86850380
40Hemorrhage of the eye (HP:0011885)1.83377471
41Neurofibrillary tangles (HP:0002185)1.74920269
42Abnormal drinking behavior (HP:0030082)1.69038324
43Polydipsia (HP:0001959)1.69038324
44Stage 5 chronic kidney disease (HP:0003774)1.66722868
45Postaxial foot polydactyly (HP:0001830)1.66716448
46Heterotopia (HP:0002282)1.66502512
47Abnormal biliary tract physiology (HP:0012439)1.65120136
48Bile duct proliferation (HP:0001408)1.65120136
49Decreased electroretinogram (ERG) amplitude (HP:0000654)1.61597440
50Abnormality of renal excretion (HP:0011036)1.60555704
51Aplasia/Hypoplasia of the lens (HP:0008063)1.55021517
52Asymmetric septal hypertrophy (HP:0001670)1.55012333
53Congenital hepatic fibrosis (HP:0002612)1.53976077
54Hypoplasia of the capital femoral epiphysis (HP:0003090)1.50865059
55Abnormality of the renal cortex (HP:0011035)1.50543188
56Exercise-induced myalgia (HP:0003738)1.49972144
57Bell-shaped thorax (HP:0001591)1.47636118
58Abnormal ventriculo-arterial connection (HP:0011563)1.46124716
59Transposition of the great arteries (HP:0001669)1.46124716
60Abnormal connection of the cardiac segments (HP:0011545)1.46124716
61Bundle branch block (HP:0011710)1.45282943
62Abnormality of the dental root (HP:0006486)1.43819164
63Taurodontia (HP:0000679)1.43819164
64Abnormality of permanent molar morphology (HP:0011071)1.43819164
65Short ribs (HP:0000773)1.42338264
66Abnormality of dentin (HP:0010299)1.42292048
67Cerebral inclusion bodies (HP:0100314)1.41254503
68Oculomotor apraxia (HP:0000657)1.40522846
69Easy fatigability (HP:0003388)1.39036159
70Abnormality of the dental pulp (HP:0006479)1.34842576
71Abnormal urine output (HP:0012590)1.34377286
72Myoglobinuria (HP:0002913)1.33816795
73Postaxial hand polydactyly (HP:0001162)1.33779934
74Constricted visual fields (HP:0001133)1.32558732
75Sensory axonal neuropathy (HP:0003390)1.32062967
76Renal dysplasia (HP:0000110)1.31835531
77Abnormality of molar (HP:0011077)1.31619272
78Abnormality of molar morphology (HP:0011070)1.31619272
79Cystic liver disease (HP:0006706)1.30891189
80Facial cleft (HP:0002006)1.30427565
81Fibular hypoplasia (HP:0003038)1.29909898
82Abnormality of the neuromuscular junction (HP:0003398)1.26400421
83Fatigable weakness (HP:0003473)1.26400421
84Hypercholesterolemia (HP:0003124)1.26129097
85Deformed sella turcica (HP:0002681)1.25072105
86Gait imbalance (HP:0002141)1.22563766
87Congenital primary aphakia (HP:0007707)1.22302144
88Hemiparesis (HP:0001269)1.21904941
89Loss of speech (HP:0002371)1.21359220
90Rhabdomyolysis (HP:0003201)1.21224442
91Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.20231130
92Abnormality of the lower motor neuron (HP:0002366)1.19295588
93Truncus arteriosus (HP:0001660)1.18207866
94Broad distal phalanx of finger (HP:0009836)1.17980887
95Cerebellar dysplasia (HP:0007033)1.17511066
96Chronic sinusitis (HP:0011109)1.17457075
97Absent epiphyses (HP:0010577)1.17332923
98Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.17332923
99Exercise-induced muscle cramps (HP:0003710)1.11343562
100Neoplasm of the heart (HP:0100544)1.11032994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.18753581
2PDK38.18753581
3TESK16.42751589
4PDK25.28795581
5PRKD35.10785880
6ICK4.63664081
7PTK2B2.14448226
8WNK42.09866411
9STK392.04089093
10STK381.81003798
11DYRK1B1.75259425
12PNCK1.65612164
13NEK21.47728360
14PDK11.27209182
15DYRK30.95882224
16CCNB10.94379798
17TYRO30.94278498
18IRAK10.88191268
19RIPK40.83024323
20MAPK150.82827904
21PDPK10.82005919
22WNK10.76052073
23PASK0.68063784
24EEF2K0.64162498
25TESK20.61145037
26PINK10.56207355
27MAP2K60.53193765
28STK30.52752012
29TTK0.50722722
30CHEK20.50260314
31NTRK20.45506921
32MUSK0.44373999
33PAK10.41495915
34IRAK20.41178703
35LMTK20.38983614
36PRKCG0.37476078
37MAPKAPK50.36568545
38STK38L0.36559795
39CAMK1G0.36285303
40MAP3K100.35208680
41CHEK10.32367978
42PAK20.25834910
43PAK40.25724224
44CAMKK10.25390947
45MARK20.24902181
46ATM0.22325790
47PRKCZ0.21289263
48PRKCQ0.20406225
49MTOR0.19503122
50CDK150.17640977
51ATR0.15386134
52CDK180.15065529
53PRKAA10.14384262
54CDK11A0.13613802
55PLK10.12665647
56BRSK20.12441088
57RPS6KB10.12235913
58PRKG20.11399085
59BRAF0.11170916
60STK110.10223717
61NEK60.09538327
62CDK140.09460451
63EPHB10.08243069
64PRKCD0.07066397
65MARK30.06710321
66RPS6KA10.06632300
67PLK40.06628096
68BRSK10.06189127
69CSNK2A10.05911672
70GSK3B0.05339472
71WEE10.05149509
72PIM10.04583890
73CSF1R0.03680131
74PRKG10.03104216
75STK100.02894787
76CAMK2A0.02529688
77PRKACG0.02221413
78PKN10.02049326
79MAPK80.02017386
80CDK60.01448510
81PRKCB0.01357201
82PRKCA0.01228503
83MAP3K10.01090539
84CDK30.00620674
85CDK10.00156551
86CDK4-0.0442917
87CLK1-0.0406404
88PRKACA-0.0363821
89PRKACB-0.0335400
90MAP3K4-0.0335117
91RPS6KA3-0.0328900
92NTRK1-0.0305262
93EGFR-0.0267574
94CSNK1D-0.0264652
95CDC7-0.0211967
96CSNK2A2-0.0197208
97ZAP70-0.0165945
98CDK2-0.0156041
99PDGFRB-0.0124892
100PAK6-0.0041583

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.80417037
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.59092396
3Vitamin B6 metabolism_Homo sapiens_hsa007503.40320821
4Pyruvate metabolism_Homo sapiens_hsa006203.33418095
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.27971881
6Linoleic acid metabolism_Homo sapiens_hsa005913.18758186
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.91923752
8Glucagon signaling pathway_Homo sapiens_hsa049222.57362421
9Propanoate metabolism_Homo sapiens_hsa006402.55498744
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.43215438
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.13252946
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.11221677
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.07602457
14Basal transcription factors_Homo sapiens_hsa030221.97997715
15Glycerolipid metabolism_Homo sapiens_hsa005611.89605826
16PPAR signaling pathway_Homo sapiens_hsa033201.86685012
17Selenocompound metabolism_Homo sapiens_hsa004501.77954076
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.72252965
19Dorso-ventral axis formation_Homo sapiens_hsa043201.65012362
20Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.62635635
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59814193
22Amphetamine addiction_Homo sapiens_hsa050311.57889285
23Fructose and mannose metabolism_Homo sapiens_hsa000511.55863694
24Mineral absorption_Homo sapiens_hsa049781.55764190
25Ether lipid metabolism_Homo sapiens_hsa005651.53282307
26Fat digestion and absorption_Homo sapiens_hsa049751.53190040
27Oocyte meiosis_Homo sapiens_hsa041141.53068286
28Pentose phosphate pathway_Homo sapiens_hsa000301.46422964
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.43393707
30Fatty acid degradation_Homo sapiens_hsa000711.43252628
31Fatty acid metabolism_Homo sapiens_hsa012121.41133103
32Cardiac muscle contraction_Homo sapiens_hsa042601.33265549
33Carbon metabolism_Homo sapiens_hsa012001.30070295
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22491976
35Antigen processing and presentation_Homo sapiens_hsa046121.16595812
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.09817801
37Renin secretion_Homo sapiens_hsa049241.08526739
38Collecting duct acid secretion_Homo sapiens_hsa049661.08305771
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05586907
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99202935
41Purine metabolism_Homo sapiens_hsa002300.95511113
42Glutathione metabolism_Homo sapiens_hsa004800.94915664
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92829316
44Biosynthesis of amino acids_Homo sapiens_hsa012300.92201632
45Hedgehog signaling pathway_Homo sapiens_hsa043400.90479279
46Fanconi anemia pathway_Homo sapiens_hsa034600.89232583
47Arachidonic acid metabolism_Homo sapiens_hsa005900.87392953
48Insulin secretion_Homo sapiens_hsa049110.87371493
49Chemical carcinogenesis_Homo sapiens_hsa052040.83535902
50Long-term potentiation_Homo sapiens_hsa047200.82259133
51Huntingtons disease_Homo sapiens_hsa050160.81884651
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.81417247
53Thyroid hormone synthesis_Homo sapiens_hsa049180.78473939
54Bile secretion_Homo sapiens_hsa049760.76951256
55Estrogen signaling pathway_Homo sapiens_hsa049150.75213271
56mRNA surveillance pathway_Homo sapiens_hsa030150.73435642
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69445665
58Salivary secretion_Homo sapiens_hsa049700.66774104
59Legionellosis_Homo sapiens_hsa051340.64123591
60Pancreatic secretion_Homo sapiens_hsa049720.58543889
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58277656
62Synaptic vesicle cycle_Homo sapiens_hsa047210.57012958
63ABC transporters_Homo sapiens_hsa020100.54708385
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.54603205
65Calcium signaling pathway_Homo sapiens_hsa040200.54284896
66RNA transport_Homo sapiens_hsa030130.52996482
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.49891718
68Gastric acid secretion_Homo sapiens_hsa049710.49570497
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48633217
70Protein digestion and absorption_Homo sapiens_hsa049740.48470853
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46209473
72Endocytosis_Homo sapiens_hsa041440.46202885
73Systemic lupus erythematosus_Homo sapiens_hsa053220.40526935
74Sulfur metabolism_Homo sapiens_hsa009200.40066338
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39605444
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39503021
77VEGF signaling pathway_Homo sapiens_hsa043700.39436406
78Inositol phosphate metabolism_Homo sapiens_hsa005620.38657647
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38465584
80Renin-angiotensin system_Homo sapiens_hsa046140.37235424
81Metabolic pathways_Homo sapiens_hsa011000.36546228
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35243393
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34737759
84AMPK signaling pathway_Homo sapiens_hsa041520.33922830
85cAMP signaling pathway_Homo sapiens_hsa040240.30624228
86Circadian entrainment_Homo sapiens_hsa047130.28255529
87Taste transduction_Homo sapiens_hsa047420.27860164
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24768543
89Alcoholism_Homo sapiens_hsa050340.23483209
90Cocaine addiction_Homo sapiens_hsa050300.21309345
91Pyrimidine metabolism_Homo sapiens_hsa002400.21226381
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17342553
93Glutamatergic synapse_Homo sapiens_hsa047240.13063003
94Wnt signaling pathway_Homo sapiens_hsa043100.12076965
95B cell receptor signaling pathway_Homo sapiens_hsa046620.11125797
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.07436124
97Salmonella infection_Homo sapiens_hsa051320.07212734
98HIF-1 signaling pathway_Homo sapiens_hsa040660.05411359
99Basal cell carcinoma_Homo sapiens_hsa052170.03199711
100Olfactory transduction_Homo sapiens_hsa047400.01331185

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