SPATA20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.97954803
2epithelial cilium movement (GO:0003351)9.85641491
3axonemal dynein complex assembly (GO:0070286)9.85016227
4plasma membrane fusion (GO:0045026)9.75040453
5motile cilium assembly (GO:0044458)9.60572793
6regulation of cilium movement (GO:0003352)9.28438943
7reproduction (GO:0000003)9.02223370
8cilium or flagellum-dependent cell motility (GO:0001539)8.64055037
9cilium movement (GO:0003341)7.95718438
10negative regulation of inclusion body assembly (GO:0090084)7.66709209
11sperm capacitation (GO:0048240)7.40903724
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.33746649
13single fertilization (GO:0007338)7.22317524
14synaptonemal complex organization (GO:0070193)7.06061210
15organic cation transport (GO:0015695)6.96728984
16piRNA metabolic process (GO:0034587)6.94043031
17synaptonemal complex assembly (GO:0007130)6.84923367
18* spermatogenesis (GO:0007283)6.80860153
19* male gamete generation (GO:0048232)6.78343675
20male meiosis (GO:0007140)6.76249259
21microtubule depolymerization (GO:0007019)6.68632927
22regulation of inclusion body assembly (GO:0090083)6.35412448
23* gamete generation (GO:0007276)6.22814278
24fertilization (GO:0009566)6.20762604
25calcium ion-dependent exocytosis (GO:0017156)5.72521867
26chromosome condensation (GO:0030261)5.54563490
27germ cell development (GO:0007281)5.53452505
28regulation of microtubule-based movement (GO:0060632)5.50766550
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.43247206
30DNA packaging (GO:0006323)5.29568228
31ventricular system development (GO:0021591)5.20238261
32glycerol ether metabolic process (GO:0006662)4.99084613
33cell recognition (GO:0008037)4.98669285
34microtubule severing (GO:0051013)4.91087977
35* multicellular organismal reproductive process (GO:0048609)4.91015232
36male meiosis I (GO:0007141)4.89003114
37spermatid nucleus differentiation (GO:0007289)4.74538784
38seminiferous tubule development (GO:0072520)4.72978424
39left/right pattern formation (GO:0060972)4.70308729
40ether metabolic process (GO:0018904)4.61121529
41chromosome organization involved in meiosis (GO:0070192)4.58366868
42DNA methylation involved in gamete generation (GO:0043046)4.40478789
43COPI coating of Golgi vesicle (GO:0048205)4.38180497
44Golgi transport vesicle coating (GO:0048200)4.38180497
45protein retention in ER lumen (GO:0006621)4.35295363
46chaperone-mediated protein complex assembly (GO:0051131)4.20417123
47sexual reproduction (GO:0019953)4.17833799
48meiotic nuclear division (GO:0007126)4.10215100
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.09502870
50single strand break repair (GO:0000012)3.96710378
51endothelial cell chemotaxis (GO:0035767)3.93520200
52* multicellular organismal development (GO:0007275)3.93054075
53meiosis I (GO:0007127)3.90210142
54semaphorin-plexin signaling pathway (GO:0071526)3.81038588
55negative regulation of cell size (GO:0045792)3.80208522
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.72592393
57protein polyglutamylation (GO:0018095)3.72275454
58cytoskeletal anchoring at plasma membrane (GO:0007016)3.66667626
59basement membrane organization (GO:0071711)3.63982712
60genitalia morphogenesis (GO:0035112)3.54950711
61protein refolding (GO:0042026)3.51273753
62regulation of spindle checkpoint (GO:0090231)3.49522759
63sequestering of actin monomers (GO:0042989)3.44600467
64mannose metabolic process (GO:0006013)3.41767938
65microtubule polymerization or depolymerization (GO:0031109)3.40188941
66insulin-like growth factor receptor signaling pathway (GO:0048009)3.39824210
67desmosome organization (GO:0002934)3.36245166
68cell-cell junction maintenance (GO:0045217)3.36193970
69meiotic cell cycle (GO:0051321)3.35616198
70RNA localization (GO:0006403)3.27208640
71carnitine transport (GO:0015879)3.26594286
72amino-acid betaine transport (GO:0015838)3.26594286
73protein localization to cilium (GO:0061512)3.24353587
74glycolytic process (GO:0006096)3.20738965
75RNA destabilization (GO:0050779)3.20563535
76adherens junction assembly (GO:0034333)3.20405711
77protein K11-linked deubiquitination (GO:0035871)3.19359744
78interferon-gamma secretion (GO:0072643)3.17690124
79nucleus organization (GO:0006997)3.15844981
80regulation of extracellular matrix disassembly (GO:0010715)3.15552600
81mitotic sister chromatid cohesion (GO:0007064)3.15366853
82negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.13422371
83cell-substrate adherens junction assembly (GO:0007045)3.10351556
84focal adhesion assembly (GO:0048041)3.10351556
85carnitine transmembrane transport (GO:1902603)3.07511450
86protein localization to endosome (GO:0036010)3.06815914
87epithelial cell-cell adhesion (GO:0090136)3.03100987
88negative regulation of fatty acid transport (GO:2000192)3.01305770
89monoubiquitinated protein deubiquitination (GO:0035520)3.00538752
90regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.99052182
91polyamine biosynthetic process (GO:0006596)2.98894462
92polyol catabolic process (GO:0046174)2.98228946
93positive regulation of macrophage activation (GO:0043032)2.96083744
94nucleoside diphosphate phosphorylation (GO:0006165)2.94615828
95barbed-end actin filament capping (GO:0051016)2.93584229
96vascular endothelial growth factor signaling pathway (GO:0038084)2.91531980
97cell-substrate junction assembly (GO:0007044)2.91130561
98apoptotic cell clearance (GO:0043277)2.91073330
99planar cell polarity pathway involved in neural tube closure (GO:0090179)2.89123298
100alditol metabolic process (GO:0019400)2.86662537
101regulation of cilium assembly (GO:1902017)2.82087884
102skin morphogenesis (GO:0043589)2.77612052
103regulation of cholesterol biosynthetic process (GO:0045540)2.76665709
104peptidyl-proline hydroxylation (GO:0019511)2.76278169
105cilium organization (GO:0044782)2.75955038
106mitochondrion degradation (GO:0000422)2.75053205
107glomerular basement membrane development (GO:0032836)2.74930603
108fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.74731280
109regulation of ARF GTPase activity (GO:0032312)2.73805697
110meiotic cell cycle process (GO:1903046)2.73123025
111microtubule-based movement (GO:0007018)2.72897574
112regulation of glucose import in response to insulin stimulus (GO:2001273)2.72192718
113cell volume homeostasis (GO:0006884)2.70578835
114activation of Rac GTPase activity (GO:0032863)2.69918486
115regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.68214998
116chromatin silencing (GO:0006342)2.68135793
117regulation of cholesterol homeostasis (GO:2000188)2.68105330
118peptidyl-glutamic acid modification (GO:0018200)2.67878451
119atrioventricular valve morphogenesis (GO:0003181)2.65931540
120cilium assembly (GO:0042384)2.64861483
121cilium morphogenesis (GO:0060271)2.64792138
122negative regulation of organelle assembly (GO:1902116)2.64150643
123regulation of plasminogen activation (GO:0010755)2.63694630
124positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62390899
125activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.62016189
126axoneme assembly (GO:0035082)2.61378547
1274-hydroxyproline metabolic process (GO:0019471)2.61119890
128positive regulation of Cdc42 GTPase activity (GO:0043089)2.60136348
129cellular component assembly involved in morphogenesis (GO:0010927)2.59908788
130stress fiber assembly (GO:0043149)2.58989094
131synapsis (GO:0007129)2.58651323
132hemidesmosome assembly (GO:0031581)2.58025899
133regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56557489
134synaptic vesicle docking involved in exocytosis (GO:0016081)2.56343445
135actin filament depolymerization (GO:0030042)2.55805211
136GTP biosynthetic process (GO:0006183)2.55758372
137intraciliary transport (GO:0042073)2.54471500
138regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.54290805
139dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.53844259
140protein hydroxylation (GO:0018126)2.52614068
141hyaluronan catabolic process (GO:0030214)2.51631927
142vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.50068722
143membrane protein ectodomain proteolysis (GO:0006509)2.49166532
144positive regulation of receptor recycling (GO:0001921)2.48455729
145cell junction maintenance (GO:0034331)2.47680342
146regulation of early endosome to late endosome transport (GO:2000641)2.47439578
147gene silencing by RNA (GO:0031047)2.46874232
148positive regulation of glycolytic process (GO:0045821)2.46246826
149membrane protein intracellular domain proteolysis (GO:0031293)2.45505519
150positive regulation of histone deacetylation (GO:0031065)2.45347443
151endothelial cell morphogenesis (GO:0001886)2.45200643
152regulation of fatty acid beta-oxidation (GO:0031998)2.44936197
153pinocytosis (GO:0006907)2.43818678
154cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.43373973
155proline biosynthetic process (GO:0006561)2.42348152
156endocardial cushion development (GO:0003197)2.42293121
157protein targeting to plasma membrane (GO:0072661)2.41573501
158positive regulation of nuclease activity (GO:0032075)2.41344777
159negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.41250987
160regulation of cholesterol metabolic process (GO:0090181)2.40337230
161regulation of ARF protein signal transduction (GO:0032012)2.36421556
162establishment of apical/basal cell polarity (GO:0035089)2.33086768
163peptide catabolic process (GO:0043171)2.32846270
164embryo implantation (GO:0007566)2.32562849
165regulation of extracellular matrix organization (GO:1903053)2.32439484
166endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.32120684
167positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.31466112
168branching involved in mammary gland duct morphogenesis (GO:0060444)2.27251586
169regulation of mammary gland epithelial cell proliferation (GO:0033599)2.25991289
170endocytic recycling (GO:0032456)2.25542959
171apoptotic process involved in morphogenesis (GO:0060561)2.25077179
172positive regulation of extracellular matrix organization (GO:1903055)2.24190473
173protein heterotrimerization (GO:0070208)2.21841615
174myelin maintenance (GO:0043217)2.20698916
175maternal placenta development (GO:0001893)2.20532496
176type B pancreatic cell proliferation (GO:0044342)2.20463576
177peptidyl-tyrosine autophosphorylation (GO:0038083)2.19445415
178cellular zinc ion homeostasis (GO:0006882)2.18567403
179actin filament bundle assembly (GO:0051017)2.18422324
180actin filament bundle organization (GO:0061572)2.18422324
181receptor recycling (GO:0001881)2.18362392
182endoplasmic reticulum unfolded protein response (GO:0030968)2.15668146
183proline metabolic process (GO:0006560)2.15066336
184glucose 6-phosphate metabolic process (GO:0051156)2.14776162
185diaphragm development (GO:0060539)2.14563335
186adhesion of symbiont to host (GO:0044406)2.14492961
187extracellular matrix disassembly (GO:0022617)2.14107924
188sperm motility (GO:0030317)14.3762134
189fusion of sperm to egg plasma membrane (GO:0007342)12.8032157
190acrosome reaction (GO:0007340)12.7292141
191cell wall macromolecule catabolic process (GO:0016998)12.3029741
192cell wall macromolecule metabolic process (GO:0044036)12.3029741
193sperm-egg recognition (GO:0035036)11.5016207
194acrosome assembly (GO:0001675)10.9832985
195binding of sperm to zona pellucida (GO:0007339)10.5310704
196multicellular organism reproduction (GO:0032504)10.4062039
197cell-cell recognition (GO:0009988)10.2918257

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.26365397
2EZH2_22144423_ChIP-Seq_EOC_Human4.38563250
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.74544222
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.71195931
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.45659257
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.20856423
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.20683791
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.06221944
9LXR_22292898_ChIP-Seq_THP-1_Human3.04414065
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.92229830
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.91151346
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.73310737
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.64002188
14VDR_22108803_ChIP-Seq_LS180_Human2.59801260
15RACK7_27058665_Chip-Seq_MCF-7_Human2.53292221
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.43827720
17* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.31272203
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.30070853
19ZNF263_19887448_ChIP-Seq_K562_Human2.23670751
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.22477934
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.18262604
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.14820246
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14104939
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03789116
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02486552
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99274091
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.98330189
28ZNF274_21170338_ChIP-Seq_K562_Hela1.98273396
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97551365
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92731044
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.88010091
32FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84748958
33* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84674029
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80509348
35KDM2B_26808549_Chip-Seq_K562_Human1.79294876
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.79227645
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76275210
38P68_20966046_ChIP-Seq_HELA_Human1.70963767
39STAT1_17558387_ChIP-Seq_HELA_Human1.70390000
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.70230733
41CLOCK_20551151_ChIP-Seq_293T_Human1.69804724
42VDR_21846776_ChIP-Seq_THP-1_Human1.69462158
43MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.68530906
44SOX2_22085726_ChIP-Seq_NPCs_Mouse1.68387587
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67677405
46KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.66207092
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.65787253
48SMC4_20622854_ChIP-Seq_HELA_Human1.65622166
49* KDM2B_26808549_Chip-Seq_DND41_Human1.65514082
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65133408
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.64321503
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.63264039
53TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.62569201
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.62390257
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60244987
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58906659
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58677072
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58557035
59SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.57075411
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.56660228
61GATA3_21867929_ChIP-Seq_CD8_Mouse1.55949137
62WDR5_24793694_ChIP-Seq_LNCAP_Human1.53878890
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50136830
64GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.49344956
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.48296054
66* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46652517
67RXR_22158963_ChIP-Seq_LIVER_Mouse1.46292576
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45982958
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.45946889
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45870386
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.45838923
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43933595
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43561899
74TP53_22127205_ChIP-Seq_IMR90_Human1.42615435
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42239821
76CBP_20019798_ChIP-Seq_JUKART_Human1.41562823
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41562823
78* CREB1_26743006_Chip-Seq_LNCaP_Human1.40819333
79P53_21459846_ChIP-Seq_SAOS-2_Human1.40101998
80ATF3_27146783_Chip-Seq_COLON_Human1.38160278
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38153995
82* CTCF_27219007_Chip-Seq_Bcells_Human1.37580888
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37134398
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36964332
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35137954
86LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.35011290
87KDM2B_26808549_Chip-Seq_REH_Human1.34403754
88REST_21632747_ChIP-Seq_MESCs_Mouse1.34098626
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.32773868
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32532339
91PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31847760
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30933475
93* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30406504
94* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29602976
95RAD21_21589869_ChIP-Seq_MESCs_Mouse1.28113729
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27412925
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27165039
98* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26389534
99TET1_21490601_ChIP-Seq_MESCs_Mouse1.26359793
100* TP63_22573176_ChIP-Seq_HFKS_Human1.24046252
101CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22927459
102GATA3_21867929_ChIP-Seq_TH1_Mouse1.22642538
103P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22380270
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22146950
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22083532
106GF1_26923725_Chip-Seq_HPCs_Mouse1.21466375
107SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21117623
108KAP1_22055183_ChIP-Seq_ESCs_Mouse1.19163996
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18078414
110ESR1_20079471_ChIP-ChIP_T-47D_Human1.17958505
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16688270
112CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16482431
113SPI1_26923725_Chip-Seq_HPCs_Mouse1.16096704
114RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15465879
115SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14981035
116FLI1_21867929_ChIP-Seq_TH2_Mouse1.14796055
117TET1_21451524_ChIP-Seq_MESCs_Mouse1.14738683
118MYC_27129775_Chip-Seq_CORNEA_Mouse1.14718066
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14681587
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13664887
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12259131
122NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11963206
123CTCF_20526341_ChIP-Seq_ESCs_Human1.11955692
124MYC_22102868_ChIP-Seq_BL_Human1.11356490
125RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11348541
126ERG_20517297_ChIP-Seq_VCAP_Human1.11264917
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10510586
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10510586
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09855221
130TBX20_22080862_ChIP-Seq_HEART_Mouse1.09369735
131TBX20_22328084_ChIP-Seq_HEART_Mouse1.09369735
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09344197
133CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09231307
134YY1_22570637_ChIP-Seq_MALME-3M_Human1.09021954
135* KDM2B_26808549_Chip-Seq_JURKAT_Human1.08727708
136GATA1_19941827_ChIP-Seq_MEL86_Mouse1.08434784
137JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.07499414
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07398479
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07239311
140NFE2_27457419_Chip-Seq_LIVER_Mouse1.07062162
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06881213
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06761515
143SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06272781
144SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06262062
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06205912
146RARA_24833708_ChIP-Seq_LIVER_Mouse1.05828628
147RARB_24833708_ChIP-Seq_LIVER_Mouse1.04834311
148ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04145198
149SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04031011
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03981061
151SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03904197
152ELF1_20517297_ChIP-Seq_JURKAT_Human1.03784059
153UBF1/2_26484160_Chip-Seq_HMECs_Human1.03040782
154CBX2_27304074_Chip-Seq_ESCs_Mouse1.02990623
155ESET_19884257_ChIP-Seq_ESCs_Mouse1.02251235
156NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01956289
157TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01406502
158SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00451867
159* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99951694
160SOX11_22085726_ChIP-Seq_ESNs_Mouse0.99753172
161MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99681414
162ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98501151
163BCOR_27268052_Chip-Seq_Bcells_Human0.98056429
164TP53_23651856_ChIP-Seq_MEFs_Mouse0.98001385
165SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97717428
166CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97219078
167PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97080812
168DROSHA_22980978_ChIP-Seq_HELA_Human0.96407971
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96268805
170PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94437009
171LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93927667
172CRX_20693478_ChIP-Seq_RETINA_Mouse0.93135043
173FLI1_21867929_ChIP-Seq_CD8_Mouse0.92469271
174* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92259691
175NANOG_20526341_ChIP-Seq_ESCs_Human0.91785202
176SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91232950
177NFYB_21822215_ChIP-Seq_K562_Human0.90943419
178SOX2_21211035_ChIP-Seq_LN229_Human0.90768093
179TAF15_26573619_Chip-Seq_HEK293_Human0.90126013
180CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89649499
181RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89093218
182PHF8_20622854_ChIP-Seq_HELA_Human0.88144789
183NANOG_18555785_Chip-Seq_ESCs_Mouse0.86460362
184KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86193218
185BCL6_27268052_Chip-Seq_Bcells_Human0.85860488
186TBL1_22424771_ChIP-Seq_293T_Human0.85057435
187PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84983069
188* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84388526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.02956224
2MP0001929_abnormal_gametogenesis5.45906296
3MP0003705_abnormal_hypodermis_morpholog4.63480571
4MP0008438_abnormal_cutaneous_collagen3.79470639
5MP0008877_abnormal_DNA_methylation3.77348555
6MP0005058_abnormal_lysosome_morphology3.66587727
7MP0002161_abnormal_fertility/fecundity3.30316317
8MP0002210_abnormal_sex_determination3.25591579
9MP0005670_abnormal_white_adipose3.21226323
10MP0005451_abnormal_body_composition2.87464348
11MP0001145_abnormal_male_reproductive2.76921497
12MP0004858_abnormal_nervous_system2.69569599
13MP0009840_abnormal_foam_cell2.48331100
14MP0005257_abnormal_intraocular_pressure2.46976824
15MP0003172_abnormal_lysosome_physiology2.43415898
16MP0000653_abnormal_sex_gland2.38210777
17MP0004272_abnormal_basement_membrane2.31525897
18MP0003566_abnormal_cell_adhesion2.29391956
19MP0002653_abnormal_ependyma_morphology2.20311816
20MP0003279_aneurysm2.17947668
21MP0000537_abnormal_urethra_morphology2.17434581
22MP0001958_emphysema2.14085893
23MP0009384_cardiac_valve_regurgitation2.13520539
24MP0003191_abnormal_cellular_cholesterol2.13501249
25MP0005410_abnormal_fertilization16.7197673
26MP0009780_abnormal_chondrocyte_physiolo1.95887314
27MP0005503_abnormal_tendon_morphology1.89627241
28MP0001348_abnormal_lacrimal_gland1.82807302
29MP0010234_abnormal_vibrissa_follicle1.80240920
30MP0003091_abnormal_cell_migration1.79497293
31MP0000003_abnormal_adipose_tissue1.72411151
32MP0005360_urolithiasis1.69476618
33MP0005409_darkened_coat_color1.69022043
34MP0003646_muscle_fatigue1.67014866
35MP0008260_abnormal_autophagy1.65428990
36MP0005076_abnormal_cell_differentiation1.56286547
37MP0002160_abnormal_reproductive_system1.52521061
38MP0004233_abnormal_muscle_weight1.49460205
39MP0002249_abnormal_larynx_morphology1.46164727
40MP0005023_abnormal_wound_healing1.44977059
41MP0000678_abnormal_parathyroid_gland1.42403002
42MP0010368_abnormal_lymphatic_system1.41702607
43MP0000767_abnormal_smooth_muscle1.40837858
44MP0000013_abnormal_adipose_tissue1.39809993
45MP0000733_abnormal_muscle_development1.39349612
46MP0004185_abnormal_adipocyte_glucose1.38614927
47MP0005275_abnormal_skin_tensile1.37591243
48MP0005623_abnormal_meninges_morphology1.36894839
49MP0002060_abnormal_skin_morphology1.34851020
50MP0002089_abnormal_postnatal_growth/wei1.29274575
51MP0000747_muscle_weakness1.26393502
52MP0002896_abnormal_bone_mineralization1.24249590
53MP0002282_abnormal_trachea_morphology1.20460531
54MP0002877_abnormal_melanocyte_morpholog1.19645110
55MP0006138_congestive_heart_failure1.15107394
56MP0002796_impaired_skin_barrier1.10984359
57MP0001765_abnormal_ion_homeostasis1.10401359
58MP0005508_abnormal_skeleton_morphology1.09703473
59MP0003453_abnormal_keratinocyte_physiol1.05220425
60MP0010030_abnormal_orbit_morphology1.02512959
61MP0002108_abnormal_muscle_morphology1.01847198
62MP0002166_altered_tumor_susceptibility1.01587592
63MP0000467_abnormal_esophagus_morphology1.00961548
64MP0000681_abnormal_thyroid_gland1.00610110
65MP0005330_cardiomyopathy0.98784092
66MP0001984_abnormal_olfaction0.98631475
67MP0000538_abnormal_urinary_bladder0.97279352
68MP0004510_myositis0.96428900
69MP0000858_altered_metastatic_potential0.94418683
70MP0000750_abnormal_muscle_regeneration0.94133632
71MP0004264_abnormal_extraembryonic_tissu0.92477838
72MP0000759_abnormal_skeletal_muscle0.91538776
73MP0002933_joint_inflammation0.90242791
74MP0004947_skin_inflammation0.90153792
75MP0003075_altered_response_to0.89357981
76MP0002234_abnormal_pharynx_morphology0.87224300
77MP0003634_abnormal_glial_cell0.86649393
78MP0003115_abnormal_respiratory_system0.84059779
79MP0002998_abnormal_bone_remodeling0.82743525
80MP0003123_paternal_imprinting0.79319527
81MP0010630_abnormal_cardiac_muscle0.79079431
82MP0000749_muscle_degeneration0.78816570
83MP0005595_abnormal_vascular_smooth0.78539308
84MP0005083_abnormal_biliary_tract0.78532811
85MP0000462_abnormal_digestive_system0.78202900
86MP0005165_increased_susceptibility_to0.77230661
87MP0005647_abnormal_sex_gland0.76211201
88MP0005390_skeleton_phenotype0.74596384
89MP0005377_hearing/vestibular/ear_phenot0.74076036
90MP0003878_abnormal_ear_physiology0.74076036
91MP0005501_abnormal_skin_physiology0.73992424
92MP0008995_early_reproductive_senescence0.73644215
93MP0005389_reproductive_system_phenotype0.73319979
94MP0005666_abnormal_adipose_tissue0.70854638
95MP0001542_abnormal_bone_strength0.70633089
96MP0001614_abnormal_blood_vessel0.69737835
97MP0009046_muscle_twitch0.69074834
98MP0003329_amyloid_beta_deposits0.65647750
99MP0003011_delayed_dark_adaptation0.65082186
100MP0004084_abnormal_cardiac_muscle0.65074316
101MP0003300_gastrointestinal_ulcer0.64301498
102MP0001533_abnormal_skeleton_physiology0.64295515
103MP0000762_abnormal_tongue_morphology0.64294257
104MP0008058_abnormal_DNA_repair0.63512319
105MP0001243_abnormal_dermal_layer0.62412504
106MP0005636_abnormal_mineral_homeostasis0.61177143
107MP0009643_abnormal_urine_homeostasis0.60097131
108MP0000163_abnormal_cartilage_morphology0.59975825
109MP0004036_abnormal_muscle_relaxation0.53044567
110MP0002269_muscular_atrophy0.51523872
111MP0000358_abnormal_cell_content/0.51315930
112MP0001324_abnormal_eye_pigmentation0.50822160
113MP0001764_abnormal_homeostasis0.50601957
114MP0000569_abnormal_digit_pigmentation0.50475775
115MP0009278_abnormal_bone_marrow0.49446351
116MP0000534_abnormal_ureter_morphology0.47751580
117MP0001293_anophthalmia0.47464292
118MP0005397_hematopoietic_system_phenotyp0.45252714
119MP0001545_abnormal_hematopoietic_system0.45252714
120MP0003699_abnormal_female_reproductive0.44356943
121MP0002736_abnormal_nociception_after0.43853241
122MP0009115_abnormal_fat_cell0.40677310
123MP0006036_abnormal_mitochondrial_physio0.40080350
124MP0002928_abnormal_bile_duct0.37440026
125MP0003950_abnormal_plasma_membrane0.36395656
126MP0003942_abnormal_urinary_system0.36289559
127MP0005253_abnormal_eye_physiology0.35884369
128MP0010094_abnormal_chromosome_stability0.34321703
129MP0000604_amyloidosis0.34123760
130MP0005551_abnormal_eye_electrophysiolog0.32239942
131MP0002971_abnormal_brown_adipose0.32097863
132MP0003879_abnormal_hair_cell0.32028812
133MP0004811_abnormal_neuron_physiology0.30710004
134MP0002295_abnormal_pulmonary_circulatio0.29948490
135MP0003111_abnormal_nucleus_morphology0.29913831
136MP0005391_vision/eye_phenotype0.29496287
137MP0004133_heterotaxia0.28850830
138MP0003633_abnormal_nervous_system0.27565751
139MP0005375_adipose_tissue_phenotype0.27480486
140MP0001730_embryonic_growth_arrest0.26736501
141MP0008961_abnormal_basal_metabolism0.26700494
142MP0003948_abnormal_gas_homeostasis0.25876389
143MP0002139_abnormal_hepatobiliary_system0.25417113
144MP0003861_abnormal_nervous_system0.24896424
145MP0000751_myopathy0.24414457
146MP0001968_abnormal_touch/_nociception0.23159806
147MP0002152_abnormal_brain_morphology0.22687646
148MP0002169_no_abnormal_phenotype0.22686615
149MP0003631_nervous_system_phenotype0.22588027
150MP0006035_abnormal_mitochondrial_morpho0.22567470
151MP0002873_normal_phenotype0.22452421
152MP0001849_ear_inflammation0.21992347
153MP0004742_abnormal_vestibular_system0.21625594
154MP0001661_extended_life_span0.20849451
155MP0004270_analgesia0.20229689
156MP0003787_abnormal_imprinting0.18983416
157MP0001119_abnormal_female_reproductive0.18947795
158MP0002092_abnormal_eye_morphology0.18251822
159MP0001727_abnormal_embryo_implantation0.18251234
160MP0003959_abnormal_lean_body0.17596947
161MP0004019_abnormal_vitamin_homeostasis0.17370899
162MP0004043_abnormal_pH_regulation0.16739306
163MP0004130_abnormal_muscle_cell0.15703183
164MP0002909_abnormal_adrenal_gland0.15295386
165MP0008569_lethality_at_weaning0.15083089
166MP0002118_abnormal_lipid_homeostasis0.15005912
167MP0008875_abnormal_xenobiotic_pharmacok0.14918812
168MP0003045_fibrosis0.14652762
169MP0005423_abnormal_somatic_nervous0.14383607
170MP0000001_mammalian_phenotype0.14062288
171MP0002229_neurodegeneration0.14033622
172MP0005365_abnormal_bile_salt0.14006683
173MP0004145_abnormal_muscle_electrophysio0.13549213
174MP0003786_premature_aging0.12980925
175MP0004087_abnormal_muscle_fiber0.12594279
176MP0000313_abnormal_cell_death0.12377679
177MP0002084_abnormal_developmental_patter0.12234968
178MP0005319_abnormal_enzyme/_coenzyme0.12176004

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.20382642
2Abnormal respiratory epithelium morphology (HP:0012253)9.20382642
3Abnormal respiratory motile cilium physiology (HP:0012261)9.07188634
4Rhinitis (HP:0012384)7.33976647
5Infertility (HP:0000789)7.26066113
6Chronic bronchitis (HP:0004469)7.18290933
7Abnormal ciliary motility (HP:0012262)6.95295723
8Nasal polyposis (HP:0100582)6.45299028
9Abnormality of the nasal mucosa (HP:0000433)5.31525481
10Male infertility (HP:0003251)5.16342000
11Protrusio acetabuli (HP:0003179)4.68053869
12Bronchitis (HP:0012387)4.65754384
13Bronchiectasis (HP:0002110)4.40215726
14Cervical subluxation (HP:0003308)4.26534390
15Nephronophthisis (HP:0000090)4.17122985
16Premature rupture of membranes (HP:0001788)4.10500215
17Abnormal spermatogenesis (HP:0008669)3.81926607
18Broad face (HP:0000283)3.48091857
19J-shaped sella turcica (HP:0002680)3.35744538
20Recurrent otitis media (HP:0000403)3.33591677
21Vertebral compression fractures (HP:0002953)3.32518970
22Cerebral aneurysm (HP:0004944)3.28721735
23Distal lower limb muscle weakness (HP:0009053)3.18633339
24Abnormality of the renal medulla (HP:0100957)3.11548684
25Impulsivity (HP:0100710)3.06141061
26Recurrent sinusitis (HP:0011108)3.06112903
27Obstructive sleep apnea (HP:0002870)3.04794729
28Dysostosis multiplex (HP:0000943)3.00815645
29Recurrent bronchitis (HP:0002837)2.97396685
30Thin bony cortex (HP:0002753)2.94613577
31Distal upper limb amyotrophy (HP:0007149)2.92835075
32Upper limb amyotrophy (HP:0009129)2.92835075
33Mucopolysacchariduria (HP:0008155)2.91685284
34Urinary glycosaminoglycan excretion (HP:0003541)2.91685284
35Cholecystitis (HP:0001082)2.81156086
36Abnormal gallbladder physiology (HP:0012438)2.81156086
37Hyperacusis (HP:0010780)2.80963902
38Biconcave vertebral bodies (HP:0004586)2.78108812
39Shallow orbits (HP:0000586)2.77710571
40Tubulointerstitial nephritis (HP:0001970)2.77423446
41Flat acetabular roof (HP:0003180)2.75213909
42Short nail (HP:0001799)2.74669932
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.74536625
44Abnormality of polysaccharide metabolism (HP:0011012)2.74536625
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.74536625
46Distal lower limb amyotrophy (HP:0008944)2.68597568
47Nuclear cataract (HP:0100018)2.67825555
48Increased connective tissue (HP:0009025)2.63691472
49Stridor (HP:0010307)2.63107729
50Tubular atrophy (HP:0000092)2.59127432
51Atrophic scars (HP:0001075)2.58809468
52Gonadotropin excess (HP:0000837)2.51788074
53Abnormality of midbrain morphology (HP:0002418)2.44079686
54Molar tooth sign on MRI (HP:0002419)2.44079686
55Tubulointerstitial abnormality (HP:0001969)2.43404019
56Fragile skin (HP:0001030)2.40208019
57Mildly elevated creatine phosphokinase (HP:0008180)2.39362436
58Spinal rigidity (HP:0003306)2.38677141
59Joint stiffness (HP:0001387)2.38087854
60Hand muscle atrophy (HP:0009130)2.37955185
61Blue sclerae (HP:0000592)2.36017365
62Achilles tendon contracture (HP:0001771)2.33335527
63Dyschromatopsia (HP:0007641)2.32236929
64Azoospermia (HP:0000027)2.29206032
65Abnormality of the Achilles tendon (HP:0005109)2.29093303
66Deep venous thrombosis (HP:0002625)2.28292103
67Wormian bones (HP:0002645)2.27402480
68Choroideremia (HP:0001139)2.23943260
69Mitral regurgitation (HP:0001653)2.23822611
70Spastic tetraparesis (HP:0001285)2.23361049
71Aortic aneurysm (HP:0004942)2.21300657
72Lymphangioma (HP:0100764)2.21164663
73Testicular atrophy (HP:0000029)2.19675305
74Ulnar bowing (HP:0003031)2.18619288
75Vascular tortuosity (HP:0004948)2.17647115
76Medial flaring of the eyebrow (HP:0010747)2.13623816
77Aneurysm (HP:0002617)2.13141475
78Abnormality of carpal bone ossification (HP:0006257)2.11791563
79Broad metatarsal (HP:0001783)2.07872525
80Spinal cord compression (HP:0002176)2.07011796
81Abnormality of the acetabulum (HP:0003170)2.06971809
82Arterial tortuosity (HP:0005116)2.05318207
83Difficulty climbing stairs (HP:0003551)2.04628000
84Testicular neoplasm (HP:0010788)2.03009407
85Bladder diverticulum (HP:0000015)2.02657438
86Tubulointerstitial fibrosis (HP:0005576)2.01798228
87Abnormality of the distal phalanges of the toes (HP:0010182)2.00804856
88Bulbar palsy (HP:0001283)2.00472390
89Dynein arm defect of respiratory motile cilia (HP:0012255)13.3863190
90Absent/shortened dynein arms (HP:0200106)13.3863190
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7939131
92Aortic dissection (HP:0002647)1.99533717
93Coxa vara (HP:0002812)1.97737229
94Advanced eruption of teeth (HP:0006288)1.96855218
95Decreased central vision (HP:0007663)1.96686374
96Abnormal ossification of hand bones (HP:0005921)1.95341042
97Osteolytic defects of the phalanges of the hand (HP:0009771)1.93150820
98Osteolytic defects of the hand bones (HP:0009699)1.93150820
99Hemorrhage of the eye (HP:0011885)1.91696143
100Axonal loss (HP:0003447)1.91060006
101Increased variability in muscle fiber diameter (HP:0003557)1.90969665
102Heterotopia (HP:0002282)1.90758483
103Interstitial pulmonary disease (HP:0006530)1.89921454
104Centrally nucleated skeletal muscle fibers (HP:0003687)1.86317188
105Neurofibrillary tangles (HP:0002185)1.86154052
106Ankle contracture (HP:0006466)1.85093984
107Long toe (HP:0010511)1.83837864
108Neonatal short-limb short stature (HP:0008921)1.83068950
109Growth hormone excess (HP:0000845)1.82799968
110Abnormality of complement system (HP:0005339)1.82564541
111Flattened epiphyses (HP:0003071)1.81681914
112Atelectasis (HP:0100750)1.81508679
113Aortic regurgitation (HP:0001659)1.81236398
114Abnormal drinking behavior (HP:0030082)1.78560257
115Polydipsia (HP:0001959)1.78560257
116Congenital glaucoma (HP:0001087)1.77815885
117Lower limb amyotrophy (HP:0007210)1.77778506
118Mitral stenosis (HP:0001718)1.77738912
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75729971
120Glucose intolerance (HP:0000833)1.74410549
121Abnormal biliary tract physiology (HP:0012439)1.74351592
122Bile duct proliferation (HP:0001408)1.74351592
123Stage 5 chronic kidney disease (HP:0003774)1.74249682
124Postaxial foot polydactyly (HP:0001830)1.73791817
125Asymmetry of the thorax (HP:0001555)1.73404651
126Acanthosis nigricans (HP:0000956)1.73359303
127Elbow flexion contracture (HP:0002987)1.72835045
128Bell-shaped thorax (HP:0001591)1.72102169
129Hypoalphalipoproteinemia (HP:0003233)1.71920075
130Generalized amyotrophy (HP:0003700)1.71553224
131Amyloidosis (HP:0011034)1.70986451
132Type 1 muscle fiber predominance (HP:0003803)1.70492042
133Natal tooth (HP:0000695)1.70335571
134Neonatal death (HP:0003811)1.69874882
135Bronchomalacia (HP:0002780)1.69092381
136Turricephaly (HP:0000262)1.68952318
137Double outlet right ventricle (HP:0001719)1.68079856
138Congenital malformation of the right heart (HP:0011723)1.68079856
139Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68066632
140Right ventricular cardiomyopathy (HP:0011663)1.67281470
141Abnormality of skeletal muscle fiber size (HP:0012084)1.65448137
142Abnormality of glycosphingolipid metabolism (HP:0004343)1.64362989
143Abnormality of glycolipid metabolism (HP:0010969)1.64362989
144Congenital hepatic fibrosis (HP:0002612)1.61542472
145Abnormality of renal excretion (HP:0011036)1.60815343
146Short ribs (HP:0000773)1.60279417
147Abnormality of the renal cortex (HP:0011035)1.54075240
148Cerebral inclusion bodies (HP:0100314)1.54019194
149Asymmetric septal hypertrophy (HP:0001670)1.49563987
150Oculomotor apraxia (HP:0000657)1.49058422
151Hemiparesis (HP:0001269)1.47080581
152Abnormality of dentin (HP:0010299)1.46563939
153Bundle branch block (HP:0011710)1.45940389
154Renal dysplasia (HP:0000110)1.43833740
155Aplasia/Hypoplasia of the lens (HP:0008063)1.41694622
156Exercise-induced myalgia (HP:0003738)1.41080426
157Hypercholesterolemia (HP:0003124)1.41062959
158Deformed sella turcica (HP:0002681)1.39957473
159Abnormal urine output (HP:0012590)1.39617780
160Abnormality of the lower motor neuron (HP:0002366)1.39590396
161Easy fatigability (HP:0003388)1.39228154
162Loss of speech (HP:0002371)1.38139920
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.37921905
164Absent epiphyses (HP:0010577)1.37921905
165Abnormality of the dental root (HP:0006486)1.37826724
166Taurodontia (HP:0000679)1.37826724
167Abnormality of permanent molar morphology (HP:0011071)1.37826724
168Myoglobinuria (HP:0002913)1.36193998
169Fibular hypoplasia (HP:0003038)1.34958477
170Postaxial hand polydactyly (HP:0001162)1.33985015
171Broad distal phalanx of finger (HP:0009836)1.29133939
172Facial cleft (HP:0002006)1.29054554
173Abnormality of the dental pulp (HP:0006479)1.28529175
174Cerebellar dysplasia (HP:0007033)1.26832680
175Cystic liver disease (HP:0006706)1.26788719
176Abnormality of molar (HP:0011077)1.26532392
177Abnormality of molar morphology (HP:0011070)1.26532392
178Sensory axonal neuropathy (HP:0003390)1.26260102
179Abnormality of the neuromuscular junction (HP:0003398)1.24953822
180Fatigable weakness (HP:0003473)1.24953822
181Amyotrophic lateral sclerosis (HP:0007354)1.24919706
182Truncal obesity (HP:0001956)1.23916277
183Constricted visual fields (HP:0001133)1.22955648
184Short femoral neck (HP:0100864)1.22798345
185Neoplasm of the heart (HP:0100544)1.21514450
186Rhabdomyolysis (HP:0003201)1.19948558
187Nephropathy (HP:0000112)1.18056766
188Short thorax (HP:0010306)1.17909693
189Absent frontal sinuses (HP:0002688)1.16208496
190Generalized muscle weakness (HP:0003324)1.16199664
191Polymicrogyria (HP:0002126)1.15541564
192Chronic sinusitis (HP:0011109)1.14665193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.44427494
2PDK37.44427494
3TESK17.16134107
4PRKD36.01069924
5ICK5.02824163
6PDK24.79650990
7EPHA23.10738433
8SIK13.09232477
9ERN12.98417268
10MST1R2.76659595
11RIPK12.27633274
12PTK2B2.27346234
13PKN22.21093699
14WNK42.11512224
15STK382.03056277
16PDGFRA1.99571338
17STK391.99543643
18PNCK1.98949556
19FGFR41.98184262
20DDR21.93144929
21NME21.92771897
22SMG11.91327434
23IRAK31.85000735
24DYRK1B1.82649636
25TTN1.74262524
26PTK21.67804667
27TNK21.63672586
28MET1.62689345
29NEK21.61130770
30PRKD21.56175997
31NTRK11.49277414
32MAP2K31.36404773
33ARAF1.32278147
34MYLK1.24036753
35PRPF4B1.23406335
36MAP3K61.22684791
37PDK11.20280498
38PTK61.13819881
39RPS6KA21.09251793
40MAP3K31.08008751
41LATS21.03281691
42MAPKAPK30.99388224
43CAMK1D0.99348189
44CDC42BPA0.95802731
45MAPK150.93766489
46FER0.93585075
47PIM20.93143907
48DYRK30.92724075
49TYRO30.90323977
50TBK10.89209512
51MAP3K110.87148463
52AKT30.83968144
53WNK10.82604426
54PDPK10.81174474
55EEF2K0.76279324
56RIPK40.76248005
57ILK0.76142933
58MAP3K130.75075252
59SCYL20.74589537
60LIMK10.73343697
61PASK0.72187649
62TESK20.69815760
63IRAK10.69293489
64RPS6KC10.63585400
65RPS6KL10.63585400
66CCNB10.63304530
67CAMK1G0.61396600
68STK30.60760480
69MAP2K20.59629197
70TAOK20.58256714
71TTK0.57845078
72PINK10.57285847
73PRKCI0.56881790
74RET0.55491788
75CDK70.54521069
76MAP3K20.54106565
77BMX0.54062829
78CHEK20.53571688
79NEK90.53556657
80MAP2K60.53123020
81EPHB20.52151472
82MAP3K70.52079972
83KSR20.49362924
84PRKD10.47349529
85NTRK20.45480425
86PAK10.45300608
87ROCK10.44718120
88HIPK20.44236328
89LRRK20.43795772
90MUSK0.43008963
91CAMK2G0.41697273
92IRAK20.41205902
93RPS6KA60.41102791
94MOS0.40253689
95FLT30.39493944
96MAPK120.38328046
97LMTK20.37320086
98MAPK110.37096281
99MAP3K100.36746284
100ABL20.36407816
101PRKCG0.35835771
102PAK40.35785861
103CHEK10.34856578
104PAK20.34770665
105DAPK30.33834134
106STK38L0.33215180
107MARK20.31895334
108MTOR0.30658681
109TGFBR20.30655351
110PRKAA20.29674118
111ROCK20.28538844
112PHKG20.28303239
113CAMKK10.27746393
114MAPKAPK50.27597000
115ATM0.24428062
116PRKAA10.21211873
117ATR0.20505307
118PRKCZ0.19190994
119NEK60.18644662
120CDK150.15616116
121RPS6KB10.14958371
122WEE10.13927522
123PRKCQ0.13792079
124CDK180.12950000
125CDK11A0.11740623
126RPS6KA10.09984118
127BRSK20.08626838
128PLK10.08229858
129PRKG20.07901666
130CDK140.07894501
131BRSK10.07122315
132GSK3B0.07064135
133TRIB30.06604290
134CDK60.06574820
135PLK40.06551147
136CSF1R0.06009691
137CLK10.05593772
138STK100.05328779
139STK110.05202515
140CSNK2A10.05168940
141CDC70.04706456
142BRAF0.03979927
143EPHB10.03034318
144CAMK2A0.03031396
145PIM10.02674822
146CSNK1D0.02650090
147PRKCD0.02460350
148PAK60.02210309
149CDK20.01950709
150MAPK80.01808367
151PRKACG0.01628144
152CDK10.01319950
153MARK30.01034021
154PRKCB0.00964882
155PRKG10.00957210
156MAP3K10.00350704
157PKN10.00345891
158TAOK1-0.0399759
159PDGFRB-0.0352288
160PRKACB-0.0333946
161CDK12-0.0332472
162ZAP70-0.0308974
163RPS6KA3-0.0231822
164AURKA-0.0175967
165CDK4-0.0110863
166EGFR-0.0097068
167CSNK2A2-0.0069774
168PRKCA-0.0016269

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.93105730
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.41722113
3Other glycan degradation_Homo sapiens_hsa005114.08275867
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.25763229
5Pyruvate metabolism_Homo sapiens_hsa006203.16641527
6Linoleic acid metabolism_Homo sapiens_hsa005913.13773512
7Vitamin B6 metabolism_Homo sapiens_hsa007503.03835292
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.90141576
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.66649161
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.55294799
11Glucagon signaling pathway_Homo sapiens_hsa049222.50164440
12Propanoate metabolism_Homo sapiens_hsa006402.37088232
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.09367929
14Glycerolipid metabolism_Homo sapiens_hsa005612.01708072
15PPAR signaling pathway_Homo sapiens_hsa033201.98985138
16Basal transcription factors_Homo sapiens_hsa030221.97207331
17Selenocompound metabolism_Homo sapiens_hsa004501.94684351
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.88700806
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.81162842
20Fructose and mannose metabolism_Homo sapiens_hsa000511.77394276
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.76473738
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.75748831
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.74773871
24ECM-receptor interaction_Homo sapiens_hsa045121.72847947
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62794064
26Dorso-ventral axis formation_Homo sapiens_hsa043201.62322916
27Fatty acid degradation_Homo sapiens_hsa000711.57990463
28Fat digestion and absorption_Homo sapiens_hsa049751.57812923
29Fatty acid metabolism_Homo sapiens_hsa012121.57578565
30Focal adhesion_Homo sapiens_hsa045101.56530463
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56377638
32Oocyte meiosis_Homo sapiens_hsa041141.53294193
33Mineral absorption_Homo sapiens_hsa049781.51677955
34Amphetamine addiction_Homo sapiens_hsa050311.51663048
35Notch signaling pathway_Homo sapiens_hsa043301.51146200
36Lysosome_Homo sapiens_hsa041421.47445298
37Ether lipid metabolism_Homo sapiens_hsa005651.46267863
38Phenylalanine metabolism_Homo sapiens_hsa003601.44661723
39Galactose metabolism_Homo sapiens_hsa000521.42352805
40Pentose phosphate pathway_Homo sapiens_hsa000301.31470553
41Carbon metabolism_Homo sapiens_hsa012001.30184555
42Cardiac muscle contraction_Homo sapiens_hsa042601.29538049
43Prion diseases_Homo sapiens_hsa050201.24178883
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22603493
45Arginine biosynthesis_Homo sapiens_hsa002201.21365446
46Insulin signaling pathway_Homo sapiens_hsa049101.15915196
47Bladder cancer_Homo sapiens_hsa052191.14494012
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13970130
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.13471279
50Antigen processing and presentation_Homo sapiens_hsa046121.12492081
51Vibrio cholerae infection_Homo sapiens_hsa051101.07204260
52Renin secretion_Homo sapiens_hsa049241.05384533
53Proteoglycans in cancer_Homo sapiens_hsa052051.05165478
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03562113
55Hedgehog signaling pathway_Homo sapiens_hsa043401.03390575
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.02838563
57Amoebiasis_Homo sapiens_hsa051461.01581848
58Chronic myeloid leukemia_Homo sapiens_hsa052201.01259147
59Acute myeloid leukemia_Homo sapiens_hsa052211.01070364
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00128717
61Fanconi anemia pathway_Homo sapiens_hsa034601.00089882
62Complement and coagulation cascades_Homo sapiens_hsa046100.98717566
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97409482
64Glutathione metabolism_Homo sapiens_hsa004800.94786605
65mTOR signaling pathway_Homo sapiens_hsa041500.94766462
66GnRH signaling pathway_Homo sapiens_hsa049120.94539922
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.94482491
68Dilated cardiomyopathy_Homo sapiens_hsa054140.92270383
69mRNA surveillance pathway_Homo sapiens_hsa030150.92196085
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91526364
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.91438240
72Purine metabolism_Homo sapiens_hsa002300.91029993
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90748638
74Tyrosine metabolism_Homo sapiens_hsa003500.88939335
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88440292
76Collecting duct acid secretion_Homo sapiens_hsa049660.87667980
77Arginine and proline metabolism_Homo sapiens_hsa003300.86630382
78Insulin secretion_Homo sapiens_hsa049110.86280174
79Endometrial cancer_Homo sapiens_hsa052130.84273807
80Arachidonic acid metabolism_Homo sapiens_hsa005900.84267666
81Huntingtons disease_Homo sapiens_hsa050160.83948175
82Glioma_Homo sapiens_hsa052140.83692201
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83439663
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83072038
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83031699
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82716455
87Non-small cell lung cancer_Homo sapiens_hsa052230.82366710
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80283837
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.80130518
90Bile secretion_Homo sapiens_hsa049760.79920760
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.79564256
92Estrogen signaling pathway_Homo sapiens_hsa049150.79041554
93Choline metabolism in cancer_Homo sapiens_hsa052310.78652509
94Small cell lung cancer_Homo sapiens_hsa052220.78381002
95Chemical carcinogenesis_Homo sapiens_hsa052040.77419138
96Thyroid hormone synthesis_Homo sapiens_hsa049180.76148830
97Tight junction_Homo sapiens_hsa045300.75679827
98Long-term potentiation_Homo sapiens_hsa047200.75384502
99Biosynthesis of amino acids_Homo sapiens_hsa012300.75352413
100RNA transport_Homo sapiens_hsa030130.75310018
101ErbB signaling pathway_Homo sapiens_hsa040120.74625173
102N-Glycan biosynthesis_Homo sapiens_hsa005100.72535608
103Histidine metabolism_Homo sapiens_hsa003400.72190958
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71157921
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70697692
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70238393
107Thyroid cancer_Homo sapiens_hsa052160.66966647
108Lysine degradation_Homo sapiens_hsa003100.65751181
109Adherens junction_Homo sapiens_hsa045200.65579015
110Legionellosis_Homo sapiens_hsa051340.64753715
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64145414
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.64101235
113Sphingolipid metabolism_Homo sapiens_hsa006000.64012604
114Hepatitis C_Homo sapiens_hsa051600.63735493
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59406374
116Pancreatic secretion_Homo sapiens_hsa049720.55768735
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55753720
118Prostate cancer_Homo sapiens_hsa052150.55278183
119Systemic lupus erythematosus_Homo sapiens_hsa053220.55073268
120Prolactin signaling pathway_Homo sapiens_hsa049170.55008894
121Salivary secretion_Homo sapiens_hsa049700.54707439
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54173748
123ABC transporters_Homo sapiens_hsa020100.53617761
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53529634
125Sulfur relay system_Homo sapiens_hsa041220.53288368
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52675042
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.52261174
128Pancreatic cancer_Homo sapiens_hsa052120.52243524
129Melanogenesis_Homo sapiens_hsa049160.51267532
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50865440
131Renin-angiotensin system_Homo sapiens_hsa046140.50622512
132Endocytosis_Homo sapiens_hsa041440.50524211
133Protein digestion and absorption_Homo sapiens_hsa049740.50079795
134AMPK signaling pathway_Homo sapiens_hsa041520.49329313
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.48594677
136Synaptic vesicle cycle_Homo sapiens_hsa047210.48097518
137Calcium signaling pathway_Homo sapiens_hsa040200.47639783
138Toxoplasmosis_Homo sapiens_hsa051450.45998121
139Gastric acid secretion_Homo sapiens_hsa049710.44603019
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41055042
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38848660
142VEGF signaling pathway_Homo sapiens_hsa043700.37124088
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36884078
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34823347
145Inositol phosphate metabolism_Homo sapiens_hsa005620.33491465
146cAMP signaling pathway_Homo sapiens_hsa040240.32470947
147Alcoholism_Homo sapiens_hsa050340.32040889
148Metabolic pathways_Homo sapiens_hsa011000.32021241
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31101117
150Sulfur metabolism_Homo sapiens_hsa009200.30654848
151Taste transduction_Homo sapiens_hsa047420.30550626
152Circadian entrainment_Homo sapiens_hsa047130.28993792
153Cocaine addiction_Homo sapiens_hsa050300.26241470
154Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24717821
155Pyrimidine metabolism_Homo sapiens_hsa002400.22466320
156Basal cell carcinoma_Homo sapiens_hsa052170.15319966
157HIF-1 signaling pathway_Homo sapiens_hsa040660.14065937
158Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.13922202
159Type II diabetes mellitus_Homo sapiens_hsa049300.11360361
160B cell receptor signaling pathway_Homo sapiens_hsa046620.10111181
161Insulin resistance_Homo sapiens_hsa049310.09562054
162Wnt signaling pathway_Homo sapiens_hsa043100.08500442
163Salmonella infection_Homo sapiens_hsa051320.08186859

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