SPATA20P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)6.39158189
2positive regulation of gamma-delta T cell activation (GO:0046645)6.27226697
3positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.91503306
4microglial cell activation (GO:0001774)5.63584728
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.62327869
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.62327869
7modulation by symbiont of host immune response (GO:0052553)5.62327869
8positive regulation by symbiont of host defense response (GO:0052509)5.62327869
9modulation by symbiont of host defense response (GO:0052031)5.62327869
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.62327869
11regulation of B cell receptor signaling pathway (GO:0050855)5.41612727
12negative regulation of cell killing (GO:0031342)5.26436242
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.26436242
14macrophage activation involved in immune response (GO:0002281)4.84571287
15neutrophil mediated immunity (GO:0002446)4.72720022
16macrophage activation (GO:0042116)4.69029366
17regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.60653940
18cellular extravasation (GO:0045123)4.59277287
19negative regulation of interleukin-12 production (GO:0032695)4.56453442
20regulation of gamma-delta T cell activation (GO:0046643)4.56136460
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54896848
22myeloid leukocyte mediated immunity (GO:0002444)4.44137363
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.43627415
24positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.43124515
25regulation of interferon-beta biosynthetic process (GO:0045357)4.38068799
26detection of external biotic stimulus (GO:0098581)4.35590857
27negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.34734076
28regulation of gamma-delta T cell differentiation (GO:0045586)4.30255264
29regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.20072991
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.04869540
31response to host immune response (GO:0052572)4.04869540
32hepatocyte apoptotic process (GO:0097284)3.93543331
33detection of biotic stimulus (GO:0009595)3.79634251
34positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.77490990
35response to host defenses (GO:0052200)3.74498673
36response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.74498673
37response to host (GO:0075136)3.74498673
38negative T cell selection (GO:0043383)3.72758245
39detection of other organism (GO:0098543)3.69939814
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.69132672
41positive thymic T cell selection (GO:0045059)3.68102424
42neutrophil activation involved in immune response (GO:0002283)3.65731938
43negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.63993252
44positive T cell selection (GO:0043368)3.61970970
45negative thymic T cell selection (GO:0045060)3.61765263
46respiratory burst (GO:0045730)3.60676786
47regulation of necroptotic process (GO:0060544)3.55277217
48negative regulation of T cell mediated immunity (GO:0002710)3.54912884
49response to peptidoglycan (GO:0032494)3.50978153
50dosage compensation (GO:0007549)3.46724668
51regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.42562418
52myeloid cell activation involved in immune response (GO:0002275)3.41573697
53positive regulation of interferon-alpha production (GO:0032727)3.39451652
54leukocyte aggregation (GO:0070486)3.38716755
55B cell receptor signaling pathway (GO:0050853)3.37478869
56negative regulation of immunoglobulin mediated immune response (GO:0002890)3.36789178
57negative regulation of B cell mediated immunity (GO:0002713)3.36789178
58negative regulation of B cell proliferation (GO:0030889)3.35008986
59defense response to protozoan (GO:0042832)3.32848924
60regulation of interferon-alpha production (GO:0032647)3.31372880
61regulation of beta-amyloid formation (GO:1902003)3.31256347
62histone H3-K36 demethylation (GO:0070544)3.24386292
63T-helper 1 type immune response (GO:0042088)3.18299609
64negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.13530433
65regulation of interleukin-12 biosynthetic process (GO:0045075)3.10940874
66production of molecular mediator involved in inflammatory response (GO:0002532)3.08612381
67regulation of interleukin-6 biosynthetic process (GO:0045408)3.08364669
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08274858
69interferon-gamma production (GO:0032609)3.05505682
70type I interferon signaling pathway (GO:0060337)3.04281207
71cellular response to type I interferon (GO:0071357)3.04281207
72response to type I interferon (GO:0034340)3.03483371
73neutrophil activation (GO:0042119)3.03363891
74negative regulation of leukocyte mediated immunity (GO:0002704)3.02774009
75positive regulation of interferon-beta production (GO:0032728)2.98138227
76negative regulation of adaptive immune response (GO:0002820)2.95170892
77histone mRNA catabolic process (GO:0071044)2.93896329
78lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93370692
79positive regulation of toll-like receptor signaling pathway (GO:0034123)2.92710438
80response to protozoan (GO:0001562)2.92467720
81interferon-gamma-mediated signaling pathway (GO:0060333)2.89649709
82negative regulation of interleukin-17 production (GO:0032700)2.89443254
83positive regulation of receptor recycling (GO:0001921)2.89101768
84negative regulation of complement activation (GO:0045916)2.87053461
85response to manganese ion (GO:0010042)2.84828128
86positive regulation of cellular amide metabolic process (GO:0034250)2.84394343
87response to interleukin-15 (GO:0070672)2.83683703
88antigen processing and presentation of endogenous antigen (GO:0019883)2.83612067
89myeloid leukocyte activation (GO:0002274)2.82844227
90T cell migration (GO:0072678)2.82532519
91phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.82353276
92positive regulation of interleukin-1 production (GO:0032732)2.80879406
93I-kappaB phosphorylation (GO:0007252)2.80671180
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.78872545
95regulation of B cell differentiation (GO:0045577)2.78741720
96immunoglobulin mediated immune response (GO:0016064)2.78727300
97granulocyte activation (GO:0036230)2.78370180
98cellular response to ethanol (GO:0071361)2.77325333
99regulation of amyloid precursor protein catabolic process (GO:1902991)2.76039839
100detection of bacterium (GO:0016045)2.75021078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.45463293
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.06897699
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.41507746
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.30872927
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.72015981
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.43618295
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.37197377
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.35957849
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.23577588
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.19821448
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.07944255
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.00807374
13RUNX_20019798_ChIP-Seq_JUKART_Human2.99495403
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.77101429
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.74760389
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69938786
17SCL_19346495_ChIP-Seq_HPC-7_Human2.60133731
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.57608800
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.46598642
20MYB_26560356_Chip-Seq_TH2_Human2.36063795
21GATA1_22025678_ChIP-Seq_K562_Human2.26137021
22SPI1_23547873_ChIP-Seq_NB4_Human2.17384877
23SPI1_23127762_ChIP-Seq_K562_Human2.16303125
24VDR_24787735_ChIP-Seq_THP-1_Human2.11190413
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91587383
26MYB_26560356_Chip-Seq_TH1_Human1.88867939
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82926286
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82143875
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81140160
30GATA3_27048872_Chip-Seq_THYMUS_Human1.74683999
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70076994
32VDR_24763502_ChIP-Seq_THP-1_Human1.65221939
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62805339
34PU_27001747_Chip-Seq_BMDM_Mouse1.62536773
35GATA1_19941827_ChIP-Seq_MEL_Mouse1.62448599
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60943253
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50533421
38GATA3_26560356_Chip-Seq_TH2_Human1.50335202
39GATA1_19941826_ChIP-Seq_K562_Human1.45787491
40MAF_26560356_Chip-Seq_TH1_Human1.44635127
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43193686
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42212712
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41999473
44TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41472308
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36202763
46GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35234412
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35225369
48GATA2_19941826_ChIP-Seq_K562_Human1.35004124
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31370535
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28901389
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.24322734
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.23478564
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22135733
54TP53_16413492_ChIP-PET_HCT116_Human1.19775393
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.19195637
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17339187
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11093758
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09100552
59GATA1_19941827_ChIP-Seq_MEL86_Mouse1.09044968
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08617829
61UTX_26944678_Chip-Seq_JUKART_Human1.07748243
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07012325
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04588427
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01824558
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97400744
66TCF7_22412390_ChIP-Seq_EML_Mouse0.94890406
67KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94567527
68SMRT_27268052_Chip-Seq_Bcells_Human0.93628279
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93248161
70ESR1_20079471_ChIP-ChIP_T-47D_Human0.92785631
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92771055
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91975931
73FOXO3_23340844_ChIP-Seq_DLD1_Human0.91169362
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90688336
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89764208
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89574207
77VDR_21846776_ChIP-Seq_THP-1_Human0.88419515
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83894742
79FLI1_27457419_Chip-Seq_LIVER_Mouse0.83261521
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83240195
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79904339
82MAF_26560356_Chip-Seq_TH2_Human0.79319346
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79168918
84GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78597931
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.77998901
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.77627285
87SALL4_22934838_ChIP-ChIP_CD34+_Human0.76157738
88ER_23166858_ChIP-Seq_MCF-7_Human0.74834044
89FLI1_21867929_ChIP-Seq_TH2_Mouse0.74675488
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.73842040
91KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73758319
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.72822344
93OCT4_21477851_ChIP-Seq_ESCs_Mouse0.72191350
94FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.71798063
95TP63_23658742_ChIP-Seq_EP156T_Human0.71684214
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.71211195
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70866838
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70641437
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.70188561
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69846581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.36720171
2MP0008260_abnormal_autophagy4.60937506
3MP0003724_increased_susceptibility_to4.56569734
4MP0003303_peritoneal_inflammation3.48119062
5MP0001835_abnormal_antigen_presentation3.41980198
6MP0005451_abnormal_body_composition3.05748678
7MP0003787_abnormal_imprinting2.81702108
8MP0003656_abnormal_erythrocyte_physiolo2.74694471
9MP0003436_decreased_susceptibility_to2.71725780
10MP0003172_abnormal_lysosome_physiology2.55650161
11MP0002419_abnormal_innate_immunity2.46517798
12MP0009785_altered_susceptibility_to2.44446515
13MP0001800_abnormal_humoral_immune2.41919875
14MP0000685_abnormal_immune_system2.25507005
15MP0004883_abnormal_blood_vessel2.23673112
16MP0004381_abnormal_hair_follicle2.20470349
17MP0005025_abnormal_response_to2.18686334
18MP0005000_abnormal_immune_tolerance2.09487519
19MP0002723_abnormal_immune_serum2.07746963
20MP0003300_gastrointestinal_ulcer2.06781604
21MP0002452_abnormal_antigen_presenting2.04091454
22MP0005671_abnormal_response_to2.00402748
23MP0002166_altered_tumor_susceptibility1.96750244
24MP0002420_abnormal_adaptive_immunity1.94258212
25MP0001819_abnormal_immune_cell1.92363924
26MP0003763_abnormal_thymus_physiology1.88172568
27MP0006082_CNS_inflammation1.85048141
28MP0000015_abnormal_ear_pigmentation1.84016913
29MP0001790_abnormal_immune_system1.80945568
30MP0005387_immune_system_phenotype1.80945568
31MP0005464_abnormal_platelet_physiology1.74255268
32MP0002148_abnormal_hypersensitivity_rea1.73982690
33MP0003221_abnormal_cardiomyocyte_apopto1.72954857
34MP0002332_abnormal_exercise_endurance1.68266621
35MP0005164_abnormal_response_to1.66900671
36MP0002405_respiratory_system_inflammati1.65982528
37MP0003828_pulmonary_edema1.65158727
38MP0005174_abnormal_tail_pigmentation1.61102861
39MP0005310_abnormal_salivary_gland1.58783614
40MP0008877_abnormal_DNA_methylation1.58026687
41MP0002398_abnormal_bone_marrow1.57648808
42MP0009764_decreased_sensitivity_to1.57087130
43MP0000716_abnormal_immune_system1.55343766
44MP0001533_abnormal_skeleton_physiology1.51906805
45MP0004947_skin_inflammation1.51836856
46MP0001845_abnormal_inflammatory_respons1.45565220
47MP0003191_abnormal_cellular_cholesterol1.45546349
48MP0000604_amyloidosis1.45065637
49MP0002006_tumorigenesis1.40811940
50MP0005075_abnormal_melanosome_morpholog1.39435435
51MP0000858_altered_metastatic_potential1.35350059
52MP0000689_abnormal_spleen_morphology1.34626158
53MP0002722_abnormal_immune_system1.33377240
54MP0009278_abnormal_bone_marrow1.33327556
55MP0005397_hematopoietic_system_phenotyp1.31898073
56MP0001545_abnormal_hematopoietic_system1.31898073
57MP0003690_abnormal_glial_cell1.30620874
58MP0002429_abnormal_blood_cell1.20926626
59MP0008057_abnormal_DNA_replication1.17693342
60MP0003329_amyloid_beta_deposits1.16915114
61MP0004484_altered_response_of1.15214236
62MP0000703_abnormal_thymus_morphology1.12269823
63MP0002132_abnormal_respiratory_system1.11587943
64MP0004808_abnormal_hematopoietic_stem1.10992091
65MP0002396_abnormal_hematopoietic_system1.10069388
66MP0003075_altered_response_to1.09283414
67MP0006054_spinal_hemorrhage1.08918215
68MP0010155_abnormal_intestine_physiology1.07974473
69MP0001958_emphysema1.07065033
70MP0008469_abnormal_protein_level1.07058478
71MP0003866_abnormal_defecation1.06549074
72MP0000465_gastrointestinal_hemorrhage1.01618584
73MP0002998_abnormal_bone_remodeling1.01004235
74MP0003195_calcinosis1.00921552
75MP0001853_heart_inflammation0.99790083
76MP0003091_abnormal_cell_migration0.99721139
77MP0003121_genomic_imprinting0.99405494
78MP0001851_eye_inflammation0.90184931
79MP0005058_abnormal_lysosome_morphology0.88228632
80MP0009765_abnormal_xenobiotic_induced0.87965205
81MP0000371_diluted_coat_color0.86533449
82MP0003448_altered_tumor_morphology0.86481380
83MP0003183_abnormal_peptide_metabolism0.86396153
84MP0004510_myositis0.85093064
85MP0005376_homeostasis/metabolism_phenot0.82887789
86MP0009763_increased_sensitivity_to0.81341871
87MP0002277_abnormal_respiratory_mucosa0.78440052
88MP0005166_decreased_susceptibility_to0.76775148
89MP0005408_hypopigmentation0.75328091
90MP0008874_decreased_physiological_sensi0.74541072
91MP0000343_altered_response_to0.73790903
92MP0003632_abnormal_nervous_system0.73577761
93MP0000249_abnormal_blood_vessel0.72262944
94MP0002909_abnormal_adrenal_gland0.71537046
95MP0008004_abnormal_stomach_pH0.71404370
96MP0003646_muscle_fatigue0.71128937
97MP0004130_abnormal_muscle_cell0.69200747
98MP0005266_abnormal_metabolism0.65969365
99MP0005076_abnormal_cell_differentiation0.59850595
100MP0001663_abnormal_digestive_system0.59527590

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)7.25107266
2Recurrent bacterial skin infections (HP:0005406)6.70183322
3Recurrent abscess formation (HP:0002722)5.86537546
4Eczematoid dermatitis (HP:0000976)5.69816410
5Retrobulbar optic neuritis (HP:0100654)5.57807098
6Optic neuritis (HP:0100653)5.57807098
7Orchitis (HP:0100796)5.33353908
8T lymphocytopenia (HP:0005403)5.26434778
9Myositis (HP:0100614)5.08098354
10Abnormality of T cell number (HP:0011839)4.92525096
11Gastrointestinal infarctions (HP:0005244)4.81362161
12Recurrent fungal infections (HP:0002841)4.37070356
13Peritonitis (HP:0002586)4.32258480
14Recurrent gram-negative bacterial infections (HP:0005420)4.24518843
15Recurrent skin infections (HP:0001581)4.13878657
16Keratoconjunctivitis sicca (HP:0001097)4.12615387
17Gingivitis (HP:0000230)4.05954708
18Elevated erythrocyte sedimentation rate (HP:0003565)3.84258033
19Keratoconjunctivitis (HP:0001096)3.80457897
20Gingival bleeding (HP:0000225)3.79633344
21Abnormality of macrophages (HP:0004311)3.71938035
22Stomatitis (HP:0010280)3.67995736
23Arterial thrombosis (HP:0004420)3.61477608
24Slow saccadic eye movements (HP:0000514)3.46932493
25Chronic mucocutaneous candidiasis (HP:0002728)3.46342309
26Recurrent cutaneous fungal infections (HP:0011370)3.46342309
27Postural instability (HP:0002172)3.41389414
28Mediastinal lymphadenopathy (HP:0100721)3.33511534
29Spontaneous hematomas (HP:0007420)3.31565283
30Subacute progressive viral hepatitis (HP:0006572)3.22332870
31Resting tremor (HP:0002322)3.17870267
32Leukocytosis (HP:0001974)3.14808305
33Recurrent viral infections (HP:0004429)3.10479079
34Hemoptysis (HP:0002105)3.09286797
35Encephalitis (HP:0002383)3.05260177
36Abnormality of T cells (HP:0002843)2.98446454
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.97276505
38Vasculitis (HP:0002633)2.96075268
39Meningitis (HP:0001287)2.94688517
40Chest pain (HP:0100749)2.94586665
41Obstructive lung disease (HP:0006536)2.91167553
42Chronic obstructive pulmonary disease (HP:0006510)2.91167553
43Urticaria (HP:0001025)2.77862114
44Abnormality of the peritoneum (HP:0002585)2.70277621
45Periodontitis (HP:0000704)2.69188616
46Gangrene (HP:0100758)2.64973636
47Epistaxis (HP:0000421)2.63585557
48Abnormality of the vasculature of the conjunctiva (HP:0008054)2.58963024
49Eosinophilia (HP:0001880)2.57981715
50Pulmonary infiltrates (HP:0002113)2.56813334
51Anorexia (HP:0002039)2.55398408
52Viral hepatitis (HP:0006562)2.53926703
53Pelvic girdle muscle weakness (HP:0003749)2.53514940
54Pulmonary embolism (HP:0002204)2.50469629
55Visual hallucinations (HP:0002367)2.46379624
56Conjunctival telangiectasia (HP:0000524)2.45862153
57Acute hepatic failure (HP:0006554)2.42616535
58Cellulitis (HP:0100658)2.36845242
59Granulocytopenia (HP:0001913)2.31560349
60Recurrent bronchitis (HP:0002837)2.31499838
61Abnormality of the endocardium (HP:0004306)2.29241914
62Episodic fever (HP:0001954)2.22894758
63Abnormality of eosinophils (HP:0001879)2.20439559
64Prolonged bleeding time (HP:0003010)2.19507391
65Myocardial infarction (HP:0001658)2.14109911
66Amyloidosis (HP:0011034)2.13436517
67Autoimmune hemolytic anemia (HP:0001890)2.11456233
68Autoimmune thrombocytopenia (HP:0001973)2.11321652
69Inflammation of the large intestine (HP:0002037)2.11127791
70Papillary thyroid carcinoma (HP:0002895)2.08507712
71Fatigue (HP:0012378)2.05987453
72Keratitis (HP:0000491)2.04459577
73Abnormality of the musculature of the pelvis (HP:0001469)2.04283346
74Abnormality of the hip-girdle musculature (HP:0001445)2.04283346
75Cerebral inclusion bodies (HP:0100314)2.02509069
76Thyroiditis (HP:0100646)1.99682947
77Neoplasm of the tracheobronchial system (HP:0100552)1.99679668
78Vertigo (HP:0002321)1.99387153
79Poikilocytosis (HP:0004447)1.96958338
80Glomerulopathy (HP:0100820)1.94589022
81Neurodegeneration (HP:0002180)1.92019915
82Orthostatic hypotension (HP:0001278)1.91556557
83Osteomyelitis (HP:0002754)1.91292746
84Colitis (HP:0002583)1.90843398
85Abnormality of the pleura (HP:0002103)1.90290475
86Gastrointestinal inflammation (HP:0004386)1.89637197
87Thrombophlebitis (HP:0004418)1.88257959
88IgA deficiency (HP:0002720)1.87648346
89Foot dorsiflexor weakness (HP:0009027)1.84770634
90Hematochezia (HP:0002573)1.83046977
91Hypoplasia of the thymus (HP:0000778)1.82135064
92Pustule (HP:0200039)1.81381146
93Amaurosis fugax (HP:0100576)1.77826358
94Microcytic anemia (HP:0001935)1.77700225
95Sepsis (HP:0100806)1.74674223
96Difficulty running (HP:0009046)1.73176303
97Stomach cancer (HP:0012126)1.72059113
98Acne (HP:0001061)1.68519401
99Cheilitis (HP:0100825)1.68158495
100Polyneuropathy (HP:0001271)1.68041892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.37130134
2BLK3.52128997
3IRAK42.95414964
4IKBKE2.89748599
5MAP2K32.76593315
6FGR2.75370962
7CSK2.69487778
8GRK62.52733683
9JAK32.26865158
10TYK22.18165153
11MAP3K142.10607803
12MAP4K12.06531539
13TXK1.96584595
14BMPR21.92332801
15IRAK11.89774369
16TAOK31.86257715
17FES1.82294941
18FRK1.79179385
19PIK3CG1.74974398
20SYK1.72168521
21WNK11.71186481
22FGFR31.67295836
23IRAK21.66227067
24MAP3K21.63758560
25SGK21.56316383
26ZAP701.55703882
27STK41.54676491
28MATK1.54265495
29PTK2B1.51135772
30JAK11.47561333
31TAOK11.47282687
32MAP3K31.43493374
33BTK1.40711085
34LRRK21.32659710
35GRK51.30261277
36HCK1.29983349
37MAP3K11.29763040
38MAP3K111.26734540
39JAK21.25990637
40LYN1.24644019
41EPHB11.21246971
42PIM11.20015304
43SGK31.19674269
44ERBB21.14887402
45MARK31.11756961
46MAP3K61.11442685
47MAP3K131.09823191
48PLK21.09089176
49TBK11.03924703
50YES11.01819689
51TEC0.97978013
52KSR20.96962665
53KSR10.94596858
54MARK20.94586235
55MAP3K50.92762484
56TGFBR20.92479353
57LCK0.92386509
58ITK0.92156064
59RAF10.91961223
60TAOK20.91119494
61IKBKB0.90619528
62FGFR40.88532180
63CAMKK20.88096047
64SGK2230.86190892
65SGK4940.86190892
66NLK0.83896353
67ACVR1B0.83728094
68DYRK1A0.72294519
69KIT0.71689946
70TRPM70.71294201
71CSF1R0.70703173
72CHUK0.65193728
73STK110.64940313
74EGFR0.61226094
75PAK30.60624241
76CLK10.60155422
77SGK10.55667264
78EPHA30.54182388
79CDC42BPA0.50937910
80DYRK30.49895032
81PDK10.49221654
82MAP2K40.49216040
83STK100.48445674
84GRK70.45467119
85CAMK1D0.44947319
86MAP3K70.44480767
87PTK60.42703890
88FYN0.42578649
89CAMK40.42489354
90STK380.40446336
91MAP2K60.38235531
92TNK20.38182169
93NEK90.36224310
94PRKAA20.33879738
95PDGFRB0.33046960
96MELK0.32941369
97ADRBK10.30764685
98RET0.30082363
99DAPK20.27879789
100RIPK10.27721939

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.21061211
2Osteoclast differentiation_Homo sapiens_hsa043802.74444446
3NOD-like receptor signaling pathway_Homo sapiens_hsa046212.58636307
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.43774896
5B cell receptor signaling pathway_Homo sapiens_hsa046622.41940239
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.25152605
7Tuberculosis_Homo sapiens_hsa051522.23224267
8Staphylococcus aureus infection_Homo sapiens_hsa051502.18002692
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.12337178
10Legionellosis_Homo sapiens_hsa051342.07167998
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.05062224
12Measles_Homo sapiens_hsa051621.96895930
13Malaria_Homo sapiens_hsa051441.96497403
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.95988951
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.84303875
16T cell receptor signaling pathway_Homo sapiens_hsa046601.79711445
17Non-small cell lung cancer_Homo sapiens_hsa052231.77338665
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71630635
19TNF signaling pathway_Homo sapiens_hsa046681.67245089
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.65761682
21Influenza A_Homo sapiens_hsa051641.63523795
22Hematopoietic cell lineage_Homo sapiens_hsa046401.59242682
23Chemokine signaling pathway_Homo sapiens_hsa040621.57983773
24Primary immunodeficiency_Homo sapiens_hsa053401.54947730
25Toxoplasmosis_Homo sapiens_hsa051451.53960738
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52579772
27Acute myeloid leukemia_Homo sapiens_hsa052211.40070750
28Hepatitis B_Homo sapiens_hsa051611.38869959
29Graft-versus-host disease_Homo sapiens_hsa053321.38301754
30Allograft rejection_Homo sapiens_hsa053301.35100100
31Autoimmune thyroid disease_Homo sapiens_hsa053201.34675833
32Prolactin signaling pathway_Homo sapiens_hsa049171.34531651
33Hepatitis C_Homo sapiens_hsa051601.28730611
34Dorso-ventral axis formation_Homo sapiens_hsa043201.27060855
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15725340
36Platelet activation_Homo sapiens_hsa046111.15109002
37Apoptosis_Homo sapiens_hsa042101.13932402
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13563606
39Phagosome_Homo sapiens_hsa041451.13096933
40Pancreatic cancer_Homo sapiens_hsa052121.13015525
41Herpes simplex infection_Homo sapiens_hsa051681.12565199
42FoxO signaling pathway_Homo sapiens_hsa040681.10459689
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.10238749
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09305346
45Pertussis_Homo sapiens_hsa051331.08450570
46VEGF signaling pathway_Homo sapiens_hsa043701.05345571
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.97369766
48Salmonella infection_Homo sapiens_hsa051320.96236612
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95572181
50Chronic myeloid leukemia_Homo sapiens_hsa052200.93484122
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.92159027
52Endometrial cancer_Homo sapiens_hsa052130.92149909
53Renal cell carcinoma_Homo sapiens_hsa052110.92143844
54Rheumatoid arthritis_Homo sapiens_hsa053230.91441680
55Antigen processing and presentation_Homo sapiens_hsa046120.90454195
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88921739
57Type I diabetes mellitus_Homo sapiens_hsa049400.85934716
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85685636
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84769375
60African trypanosomiasis_Homo sapiens_hsa051430.84185789
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82898421
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82504771
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79928929
64Inositol phosphate metabolism_Homo sapiens_hsa005620.79387100
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.78945538
66mTOR signaling pathway_Homo sapiens_hsa041500.78893047
67HIF-1 signaling pathway_Homo sapiens_hsa040660.70201944
68Shigellosis_Homo sapiens_hsa051310.69710057
69Amoebiasis_Homo sapiens_hsa051460.66902364
70Asthma_Homo sapiens_hsa053100.64165705
71Glioma_Homo sapiens_hsa052140.64137687
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.63740228
73Viral myocarditis_Homo sapiens_hsa054160.62964770
74Fatty acid biosynthesis_Homo sapiens_hsa000610.62140799
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60303994
76ErbB signaling pathway_Homo sapiens_hsa040120.59644076
77Type II diabetes mellitus_Homo sapiens_hsa049300.58585012
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58562506
79GnRH signaling pathway_Homo sapiens_hsa049120.58510607
80Insulin resistance_Homo sapiens_hsa049310.58341559
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58175594
82Notch signaling pathway_Homo sapiens_hsa043300.57444257
83Prostate cancer_Homo sapiens_hsa052150.52170381
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51939026
85Viral carcinogenesis_Homo sapiens_hsa052030.51719117
86Lysosome_Homo sapiens_hsa041420.51594107
87MAPK signaling pathway_Homo sapiens_hsa040100.49959829
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49404197
89Choline metabolism in cancer_Homo sapiens_hsa052310.49325909
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48976161
91Epstein-Barr virus infection_Homo sapiens_hsa051690.47261065
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45112429
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43532301
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.43310618
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43296175
96Complement and coagulation cascades_Homo sapiens_hsa046100.42669496
97Long-term potentiation_Homo sapiens_hsa047200.42334629
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41312004
99MicroRNAs in cancer_Homo sapiens_hsa052060.39424866
100Endocytosis_Homo sapiens_hsa041440.39210228

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