SPATA21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.94376367
2epithelial cilium movement (GO:0003351)9.67135400
3plasma membrane fusion (GO:0045026)9.64474757
4axonemal dynein complex assembly (GO:0070286)9.62590372
5motile cilium assembly (GO:0044458)9.46033101
6regulation of cilium movement (GO:0003352)9.02914414
7reproduction (GO:0000003)9.01037518
8cilium or flagellum-dependent cell motility (GO:0001539)8.22637434
9cilium movement (GO:0003341)7.80881035
10negative regulation of inclusion body assembly (GO:0090084)7.63379705
11sperm capacitation (GO:0048240)7.33082939
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.17144552
13single fertilization (GO:0007338)7.16300129
14synaptonemal complex organization (GO:0070193)7.11371740
15organic cation transport (GO:0015695)6.99343705
16synaptonemal complex assembly (GO:0007130)6.97173869
17spermatogenesis (GO:0007283)6.96172731
18male gamete generation (GO:0048232)6.93624737
19piRNA metabolic process (GO:0034587)6.85518322
20male meiosis (GO:0007140)6.78612312
21microtubule depolymerization (GO:0007019)6.70904508
22response to pheromone (GO:0019236)6.60998532
23gamete generation (GO:0007276)6.38099815
24regulation of inclusion body assembly (GO:0090083)6.33361892
25fertilization (GO:0009566)6.18686809
26chromosome condensation (GO:0030261)5.81559181
27calcium ion-dependent exocytosis (GO:0017156)5.71659227
28DNA packaging (GO:0006323)5.55153693
29germ cell development (GO:0007281)5.53630688
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.45952671
31regulation of microtubule-based movement (GO:0060632)5.33465566
32ventricular system development (GO:0021591)5.08838222
33microtubule severing (GO:0051013)5.07120857
34multicellular organismal reproductive process (GO:0048609)5.02472544
35cell recognition (GO:0008037)5.00384107
36glycerol ether metabolic process (GO:0006662)4.96338202
37spermatid nucleus differentiation (GO:0007289)4.89876472
38behavioral response to nicotine (GO:0035095)4.87046744
39male meiosis I (GO:0007141)4.83440725
40seminiferous tubule development (GO:0072520)4.76581772
41chromosome organization involved in meiosis (GO:0070192)4.66279764
42ether metabolic process (GO:0018904)4.58488654
43left/right pattern formation (GO:0060972)4.55132070
44DNA methylation involved in gamete generation (GO:0043046)4.39791391
45cellular ketone body metabolic process (GO:0046950)4.32270408
46sexual reproduction (GO:0019953)4.25670291
47tryptophan catabolic process (GO:0006569)4.23923534
48indole-containing compound catabolic process (GO:0042436)4.23923534
49indolalkylamine catabolic process (GO:0046218)4.23923534
50chaperone-mediated protein complex assembly (GO:0051131)4.20960778
51single strand break repair (GO:0000012)4.13179721
52meiotic nuclear division (GO:0007126)4.12753981
53multicellular organismal development (GO:0007275)4.04115368
54fucose catabolic process (GO:0019317)4.02407732
55L-fucose metabolic process (GO:0042354)4.02407732
56L-fucose catabolic process (GO:0042355)4.02407732
57kynurenine metabolic process (GO:0070189)3.93183480
58indolalkylamine metabolic process (GO:0006586)3.87094617
59meiosis I (GO:0007127)3.87035235
60ketone body metabolic process (GO:1902224)3.84814766
61water-soluble vitamin biosynthetic process (GO:0042364)3.80204882
62sequestering of actin monomers (GO:0042989)3.78883424
63protein polyglutamylation (GO:0018095)3.75566153
64DNA deamination (GO:0045006)3.74709607
65negative regulation of telomere maintenance (GO:0032205)3.58015649
66regulation of spindle checkpoint (GO:0090231)3.56548875
67tryptophan metabolic process (GO:0006568)3.53541206
68genitalia morphogenesis (GO:0035112)3.50377809
69microtubule polymerization or depolymerization (GO:0031109)3.43597667
70detection of light stimulus involved in visual perception (GO:0050908)3.43447268
71detection of light stimulus involved in sensory perception (GO:0050962)3.43447268
72cellular biogenic amine catabolic process (GO:0042402)3.42172458
73amine catabolic process (GO:0009310)3.42172458
74protein refolding (GO:0042026)3.41396127
75meiotic cell cycle (GO:0051321)3.35981209
76detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.31285779
77RNA localization (GO:0006403)3.28010133
78protein K11-linked deubiquitination (GO:0035871)3.27896170
79interferon-gamma secretion (GO:0072643)3.24387328
80RNA destabilization (GO:0050779)3.22332633
81carnitine transport (GO:0015879)3.21345522
82amino-acid betaine transport (GO:0015838)3.21345522
83nucleus organization (GO:0006997)3.19301832
84mitotic sister chromatid cohesion (GO:0007064)3.19036005
85establishment of protein localization to Golgi (GO:0072600)3.17051624
86protein localization to cilium (GO:0061512)3.16938717
87glycolytic process (GO:0006096)3.12178011
88positive regulation of macrophage activation (GO:0043032)3.11996378
89NAD biosynthetic process (GO:0009435)3.10766389
90polyamine biosynthetic process (GO:0006596)3.09656132
91monoubiquitinated protein deubiquitination (GO:0035520)3.07816908
92carnitine transmembrane transport (GO:1902603)3.01858839
93pyrimidine nucleobase catabolic process (GO:0006208)3.01135860
94regulation of meiosis I (GO:0060631)3.00433060
95regulation of action potential (GO:0098900)2.97019310
96platelet dense granule organization (GO:0060155)2.94629601
97mannosylation (GO:0097502)2.92947689
98polyol catabolic process (GO:0046174)2.91293704
99protein targeting to Golgi (GO:0000042)2.90835110
100photoreceptor cell maintenance (GO:0045494)2.90504435
101nucleoside diphosphate phosphorylation (GO:0006165)2.89256165
102nephron epithelium morphogenesis (GO:0072088)2.87988370
103nephron tubule morphogenesis (GO:0072078)2.87988370
104retinal cone cell development (GO:0046549)2.86300015
105aromatic amino acid family catabolic process (GO:0009074)2.83899080
106regulation of cilium assembly (GO:1902017)2.82578141
107indole-containing compound metabolic process (GO:0042430)2.81438945
108nucleobase catabolic process (GO:0046113)2.79520751
109alditol metabolic process (GO:0019400)2.79331258
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79290834
111meiotic cell cycle process (GO:1903046)2.79182492
112chromatin silencing (GO:0006342)2.78067522
113regulation of glucokinase activity (GO:0033131)2.77325658
114regulation of hexokinase activity (GO:1903299)2.77325658
115centriole replication (GO:0007099)2.76931533
116mitochondrion degradation (GO:0000422)2.75908780
117negative regulation of mast cell activation (GO:0033004)2.74757672
118somite development (GO:0061053)2.73200276
119cilium organization (GO:0044782)2.72458709
120respiratory chain complex IV assembly (GO:0008535)2.72362974
121rRNA modification (GO:0000154)2.71849945
122L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70469371
123neuronal action potential (GO:0019228)2.69950380
124auditory receptor cell stereocilium organization (GO:0060088)2.69038655
125preassembly of GPI anchor in ER membrane (GO:0016254)2.68870597
126microtubule-based movement (GO:0007018)2.66919832
127protein localization to Golgi apparatus (GO:0034067)2.64688990
128cilium morphogenesis (GO:0060271)2.63106668
129peptidyl-glutamic acid modification (GO:0018200)2.61771590
130synapsis (GO:0007129)2.61300704
131cilium assembly (GO:0042384)2.61212925
132negative regulation of organelle assembly (GO:1902116)2.60477927
133phosphatidylethanolamine biosynthetic process (GO:0006646)2.59738837
134oxidative demethylation (GO:0070989)2.59575571
135cellular response to ATP (GO:0071318)2.59443061
136sulfation (GO:0051923)2.59183921
137regulation of telomere maintenance (GO:0032204)2.58986100
138axoneme assembly (GO:0035082)2.58933240
139cellular component assembly involved in morphogenesis (GO:0010927)2.58745367
140coenzyme catabolic process (GO:0009109)2.58497351
141positive regulation of sodium ion transmembrane transport (GO:1902307)2.58302922
142synaptic transmission, cholinergic (GO:0007271)2.57134711
143negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56827161
144protein complex biogenesis (GO:0070271)2.54443758
145L-methionine salvage (GO:0071267)2.53649968
146L-methionine biosynthetic process (GO:0071265)2.53649968
147amino acid salvage (GO:0043102)2.53649968
148positive regulation of meiosis (GO:0045836)2.53388309
149GTP biosynthetic process (GO:0006183)2.51978918
150rRNA methylation (GO:0031167)2.51735658
151S-adenosylmethionine metabolic process (GO:0046500)2.51528293
152replication fork processing (GO:0031297)2.50890275
153phosphatidylethanolamine metabolic process (GO:0046337)2.50826277
154tyrosine phosphorylation of STAT protein (GO:0007260)2.50668228
155nonmotile primary cilium assembly (GO:0035058)2.50411125
156intraciliary transport (GO:0042073)2.48503204
157positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.47355251
158cornea development in camera-type eye (GO:0061303)2.47136632
159membrane protein intracellular domain proteolysis (GO:0031293)2.45253247
160nucleosome disassembly (GO:0006337)2.43340447
161protein-DNA complex disassembly (GO:0032986)2.43340447
162sperm motility (GO:0030317)14.1963668
163cell wall macromolecule catabolic process (GO:0016998)12.7185480
164cell wall macromolecule metabolic process (GO:0044036)12.7185480
165acrosome reaction (GO:0007340)12.7136559
166fusion of sperm to egg plasma membrane (GO:0007342)12.6707343
167sperm-egg recognition (GO:0035036)11.5659925
168acrosome assembly (GO:0001675)11.2702085
169binding of sperm to zona pellucida (GO:0007339)10.6094043
170multicellular organism reproduction (GO:0032504)10.3685672
171cell-cell recognition (GO:0009988)10.3490862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.24913006
2EZH2_22144423_ChIP-Seq_EOC_Human4.25905445
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.79577000
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.01502290
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.97461138
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.97034312
7GBX2_23144817_ChIP-Seq_PC3_Human2.74076527
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.70707322
9VDR_22108803_ChIP-Seq_LS180_Human2.55884562
10IGF1R_20145208_ChIP-Seq_DFB_Human2.45109645
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.36590953
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.35507885
13FUS_26573619_Chip-Seq_HEK293_Human2.21882305
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18829976
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18147868
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17219874
17P300_19829295_ChIP-Seq_ESCs_Human2.08652923
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04863853
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04849935
20ZNF274_21170338_ChIP-Seq_K562_Hela1.98948048
21EWS_26573619_Chip-Seq_HEK293_Human1.94356015
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93643919
23* ER_23166858_ChIP-Seq_MCF-7_Human1.90287579
24FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87395453
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.81795558
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.81775474
27TAF15_26573619_Chip-Seq_HEK293_Human1.80793073
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80633332
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.72511557
30STAT1_17558387_ChIP-Seq_HELA_Human1.72255001
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.71542437
32SOX2_22085726_ChIP-Seq_NPCs_Mouse1.70899186
33MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.68873972
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.63595397
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59330858
36TP53_22573176_ChIP-Seq_HFKS_Human1.56034388
37FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.55576150
38* GATA3_21867929_ChIP-Seq_CD8_Mouse1.54126280
39AR_25329375_ChIP-Seq_VCAP_Human1.52919611
40WDR5_24793694_ChIP-Seq_LNCAP_Human1.50451709
41GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50057433
42STAT3_23295773_ChIP-Seq_U87_Human1.46045000
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45826403
44SOX2_19829295_ChIP-Seq_ESCs_Human1.45784355
45NANOG_19829295_ChIP-Seq_ESCs_Human1.45784355
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45289437
47IRF1_19129219_ChIP-ChIP_H3396_Human1.44821220
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41931803
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41360487
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39939591
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39692344
52CBP_20019798_ChIP-Seq_JUKART_Human1.39692344
53BCAT_22108803_ChIP-Seq_LS180_Human1.39181728
54AR_21572438_ChIP-Seq_LNCaP_Human1.37846688
55LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.35870270
56* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35154367
57SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35124042
58KDM2B_26808549_Chip-Seq_REH_Human1.35061042
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34651536
60SMAD4_21799915_ChIP-Seq_A2780_Human1.34008688
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.33394152
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33394152
63* P53_21459846_ChIP-Seq_SAOS-2_Human1.33273126
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.33067831
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32636814
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32536990
67REST_21632747_ChIP-Seq_MESCs_Mouse1.32047096
68TCF4_23295773_ChIP-Seq_U87_Human1.31966612
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31568850
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.31542008
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.31408363
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29710792
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29116633
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.29028340
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28596320
76TCF4_22108803_ChIP-Seq_LS180_Human1.28364146
77* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28140996
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28095390
79RAD21_21589869_ChIP-Seq_MESCs_Mouse1.27706764
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27326634
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27069158
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27033105
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.27019085
84MYC_19829295_ChIP-Seq_ESCs_Human1.26632111
85KAP1_22055183_ChIP-Seq_ESCs_Mouse1.26133503
86GATA3_21867929_ChIP-Seq_TH1_Mouse1.25337815
87CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25063984
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.25021665
89SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24828957
90RUNX2_22187159_ChIP-Seq_PCA_Human1.24046873
91GF1_26923725_Chip-Seq_HPCs_Mouse1.23678722
92NCOR_22424771_ChIP-Seq_293T_Human1.22127797
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20399113
94ERA_21632823_ChIP-Seq_H3396_Human1.20011394
95CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19525841
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19404468
97HOXB7_26014856_ChIP-Seq_BT474_Human1.18953418
98SPI1_26923725_Chip-Seq_HPCs_Mouse1.18659498
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.17158064
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.16728854
101SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16491966
102RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16225492
103MYC_27129775_Chip-Seq_CORNEA_Mouse1.14984702
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14304774
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14256214
106RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13943559
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13737499
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12974988
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.12943057
110ERG_20517297_ChIP-Seq_VCAP_Human1.12264064
111TAF2_19829295_ChIP-Seq_ESCs_Human1.12257770
112AR_20517297_ChIP-Seq_VCAP_Human1.12180425
113GATA1_19941827_ChIP-Seq_MEL86_Mouse1.11143348
114MYC_18940864_ChIP-ChIP_HL60_Human1.11061528
115EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10789941
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.10663073
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10261329
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10144464
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10144464
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.10095256
121JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.08959875
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.08925318
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.08084261
124RARA_24833708_ChIP-Seq_LIVER_Mouse1.07573326
125PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06697304
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06583511
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06113564
128CBX2_27304074_Chip-Seq_ESCs_Mouse1.06100138
129* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05995314
130ESET_19884257_ChIP-Seq_ESCs_Mouse1.05696076
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05549996
132CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04483700
133* OCT4_20526341_ChIP-Seq_ESCs_Human1.04388939
134ELF1_20517297_ChIP-Seq_JURKAT_Human1.03876478
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03410975
136GABP_17652178_ChIP-ChIP_JURKAT_Human1.02352157
137* CTCF_20526341_ChIP-Seq_ESCs_Human1.02332586
138SOX11_22085726_ChIP-Seq_ESNs_Mouse1.00740203
139NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00577000
140BCOR_27268052_Chip-Seq_Bcells_Human0.99330390
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99153247
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98445490
143LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98200976
144* FOXH1_21741376_ChIP-Seq_EPCs_Human0.98058195
145* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97673764
146CDX2_22108803_ChIP-Seq_LS180_Human0.97531280
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97086101
148REST_18959480_ChIP-ChIP_MESCs_Mouse0.95578707
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95393289
150CRX_20693478_ChIP-Seq_RETINA_Mouse0.94969248
151* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94662770
152FLI1_21867929_ChIP-Seq_CD8_Mouse0.94487297
153* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94449772
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94313844
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94174942
156SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93407908
157RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93290389
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91459384
159NANOG_20526341_ChIP-Seq_ESCs_Human0.91338362
160SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91003253
161RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90613844
162NANOG_18555785_Chip-Seq_ESCs_Mouse0.89988459
163SOX2_21211035_ChIP-Seq_LN229_Human0.89460178
164PHF8_20622854_ChIP-Seq_HELA_Human0.89198970
165CTCF_27219007_Chip-Seq_Bcells_Human0.87573126
166BCL6_27268052_Chip-Seq_Bcells_Human0.86450122
167SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85647454
168NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85355096
169STAT3_18555785_ChIP-Seq_MESCs_Mouse0.84813220
170OCT4_18555785_Chip-Seq_ESCs_Mouse0.83743397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.02298763
2MP0001929_abnormal_gametogenesis5.52636944
3MP0008877_abnormal_DNA_methylation3.82476910
4MP0002161_abnormal_fertility/fecundity3.31456278
5MP0002210_abnormal_sex_determination3.29351067
6MP0005670_abnormal_white_adipose3.16812645
7MP0003195_calcinosis2.80739789
8MP0001145_abnormal_male_reproductive2.80432941
9MP0005646_abnormal_pituitary_gland2.52609068
10MP0006292_abnormal_olfactory_placode2.51696212
11MP0000653_abnormal_sex_gland2.43550489
12MP0002653_abnormal_ependyma_morphology2.17626120
13MP0008872_abnormal_physiological_respon2.04097560
14MP0005645_abnormal_hypothalamus_physiol2.02688226
15MP0005410_abnormal_fertilization16.6876382
16MP0003880_abnormal_central_pattern1.97297251
17MP0001986_abnormal_taste_sensitivity1.92938951
18MP0002876_abnormal_thyroid_physiology1.88295613
19MP0002837_dystrophic_cardiac_calcinosis1.82272322
20MP0003646_muscle_fatigue1.76597908
21MP0009745_abnormal_behavioral_response1.76362001
22MP0002272_abnormal_nervous_system1.72822159
23MP0006072_abnormal_retinal_apoptosis1.72392411
24MP0005423_abnormal_somatic_nervous1.70405237
25MP0002138_abnormal_hepatobiliary_system1.67235878
26MP0006276_abnormal_autonomic_nervous1.66106264
27MP0005084_abnormal_gallbladder_morpholo1.65327388
28MP0001486_abnormal_startle_reflex1.64869670
29MP0002160_abnormal_reproductive_system1.58868329
30MP0003136_yellow_coat_color1.52571288
31MP0004233_abnormal_muscle_weight1.52211328
32MP0002254_reproductive_system_inflammat1.49947610
33MP0001501_abnormal_sleep_pattern1.46299355
34MP0002735_abnormal_chemical_nociception1.41795968
35MP0005379_endocrine/exocrine_gland_phen1.40978020
36MP0001485_abnormal_pinna_reflex1.37142383
37MP0004142_abnormal_muscle_tone1.35922645
38MP0002638_abnormal_pupillary_reflex1.35547891
39MP0002557_abnormal_social/conspecific_i1.31843970
40MP0003718_maternal_effect1.31119179
41MP0002572_abnormal_emotion/affect_behav1.31044672
42MP0000631_abnormal_neuroendocrine_gland1.30548264
43MP0005623_abnormal_meninges_morphology1.29072634
44MP0002938_white_spotting1.24075466
45MP0003122_maternal_imprinting1.21371820
46MP0008775_abnormal_heart_ventricle1.17791246
47MP0002064_seizures1.16587359
48MP0000427_abnormal_hair_cycle1.14480059
49MP0002282_abnormal_trachea_morphology1.12567803
50MP0001970_abnormal_pain_threshold1.12118148
51MP0002733_abnormal_thermal_nociception1.08328332
52MP0010329_abnormal_lipoprotein_level1.06920774
53MP0001765_abnormal_ion_homeostasis1.06184380
54MP0005332_abnormal_amino_acid1.05972689
55MP0001502_abnormal_circadian_rhythm1.04368798
56MP0000372_irregular_coat_pigmentation1.04310277
57MP0002067_abnormal_sensory_capabilities1.04108887
58MP0005085_abnormal_gallbladder_physiolo1.02435205
59MP0005167_abnormal_blood-brain_barrier1.02022241
60MP0001984_abnormal_olfaction1.00099082
61MP0002163_abnormal_gland_morphology0.99912793
62MP0004885_abnormal_endolymph0.99454961
63MP0002063_abnormal_learning/memory/cond0.96512371
64MP0010386_abnormal_urinary_bladder0.96059596
65MP0001905_abnormal_dopamine_level0.95403247
66MP0005174_abnormal_tail_pigmentation0.94279035
67MP0002234_abnormal_pharynx_morphology0.93876599
68MP0000026_abnormal_inner_ear0.93094155
69MP0003121_genomic_imprinting0.91149168
70MP0005195_abnormal_posterior_eye0.90831789
71MP0002734_abnormal_mechanical_nocicepti0.90700823
72MP0003635_abnormal_synaptic_transmissio0.90675999
73MP0001963_abnormal_hearing_physiology0.90551797
74MP0000230_abnormal_systemic_arterial0.89098453
75MP0001529_abnormal_vocalization0.88032259
76MP0005386_behavior/neurological_phenoty0.87515419
77MP0004924_abnormal_behavior0.87515419
78MP0001348_abnormal_lacrimal_gland0.86652089
79MP0002095_abnormal_skin_pigmentation0.83824805
80MP0001919_abnormal_reproductive_system0.83526031
81MP0002184_abnormal_innervation0.82882925
82MP0002752_abnormal_somatic_nervous0.82328422
83MP0000015_abnormal_ear_pigmentation0.82296584
84MP0000778_abnormal_nervous_system0.79346808
85MP0005389_reproductive_system_phenotype0.79081856
86MP0002277_abnormal_respiratory_mucosa0.78918667
87MP0003115_abnormal_respiratory_system0.78661409
88MP0003119_abnormal_digestive_system0.78375941
89MP0005647_abnormal_sex_gland0.76505655
90MP0008995_early_reproductive_senescence0.73523657
91MP0008058_abnormal_DNA_repair0.73325034
92MP0005377_hearing/vestibular/ear_phenot0.69446566
93MP0003878_abnormal_ear_physiology0.69446566
94MP0009046_muscle_twitch0.67603201
95MP0005666_abnormal_adipose_tissue0.66650912
96MP0003011_delayed_dark_adaptation0.63146657
97MP0003329_amyloid_beta_deposits0.61814704
98MP0005636_abnormal_mineral_homeostasis0.58855553
99MP0004036_abnormal_muscle_relaxation0.52164357
100MP0002269_muscular_atrophy0.50915388
101MP0003699_abnormal_female_reproductive0.50742889
102MP0000358_abnormal_cell_content/0.49256626
103MP0001324_abnormal_eye_pigmentation0.48410833
104MP0009278_abnormal_bone_marrow0.47711446
105MP0001764_abnormal_homeostasis0.47624443
106MP0001545_abnormal_hematopoietic_system0.47248905
107MP0005397_hematopoietic_system_phenotyp0.47248905
108MP0000569_abnormal_digit_pigmentation0.47178203
109MP0001293_anophthalmia0.45476678
110MP0000534_abnormal_ureter_morphology0.45471905
111MP0010094_abnormal_chromosome_stability0.44858183
112MP0002736_abnormal_nociception_after0.43960465
113MP0006036_abnormal_mitochondrial_physio0.43396493
114MP0003111_abnormal_nucleus_morphology0.39820718
115MP0009115_abnormal_fat_cell0.38264891
116MP0003950_abnormal_plasma_membrane0.36615214
117MP0005253_abnormal_eye_physiology0.35487254
118MP0003942_abnormal_urinary_system0.34742119
119MP0003879_abnormal_hair_cell0.34445675
120MP0002928_abnormal_bile_duct0.33444226
121MP0001730_embryonic_growth_arrest0.32148781
122MP0005551_abnormal_eye_electrophysiolog0.31034350
123MP0000604_amyloidosis0.30801294
124MP0004133_heterotaxia0.30310801
125MP0004811_abnormal_neuron_physiology0.29582502
126MP0005391_vision/eye_phenotype0.29178537
127MP0002971_abnormal_brown_adipose0.27997993
128MP0002295_abnormal_pulmonary_circulatio0.27514778
129MP0003787_abnormal_imprinting0.27473289
130MP0003861_abnormal_nervous_system0.26368655
131MP0001119_abnormal_female_reproductive0.25668003
132MP0002169_no_abnormal_phenotype0.24011961
133MP0003633_abnormal_nervous_system0.23968761
134MP0003948_abnormal_gas_homeostasis0.23891545
135MP0002873_normal_phenotype0.23779669
136MP0005375_adipose_tissue_phenotype0.23154443
137MP0002139_abnormal_hepatobiliary_system0.23121915
138MP0002152_abnormal_brain_morphology0.22486707
139MP0001661_extended_life_span0.22353827
140MP0001849_ear_inflammation0.21972401
141MP0001968_abnormal_touch/_nociception0.21688062
142MP0002102_abnormal_ear_morphology0.21653963
143MP0003631_nervous_system_phenotype0.20535110
144MP0006035_abnormal_mitochondrial_morpho0.20265683
145MP0008961_abnormal_basal_metabolism0.20068902
146MP0004742_abnormal_vestibular_system0.19152506
147MP0000751_myopathy0.18642261
148MP0003786_premature_aging0.17978004
149MP0004019_abnormal_vitamin_homeostasis0.17833023
150MP0002092_abnormal_eye_morphology0.17811773
151MP0004145_abnormal_muscle_electrophysio0.16994255
152MP0001727_abnormal_embryo_implantation0.16515233
153MP0008007_abnormal_cellular_replicative0.16454660
154MP0004270_analgesia0.16211649
155MP0002084_abnormal_developmental_patter0.15747070
156MP0000001_mammalian_phenotype0.15001710
157MP0000313_abnormal_cell_death0.14783142
158MP0010307_abnormal_tumor_latency0.14354784
159MP0003959_abnormal_lean_body0.14006565
160MP0001672_abnormal_embryogenesis/_devel0.13594622
161MP0005380_embryogenesis_phenotype0.13594622
162MP0002909_abnormal_adrenal_gland0.13309058
163MP0000462_abnormal_digestive_system0.13294573
164MP0008569_lethality_at_weaning0.12835132
165MP0008875_abnormal_xenobiotic_pharmacok0.12348224
166MP0002229_neurodegeneration0.12293818
167MP0001697_abnormal_embryo_size0.12088087
168MP0004043_abnormal_pH_regulation0.12079178

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.15011334
2Abnormal respiratory epithelium morphology (HP:0012253)9.13177134
3Abnormal respiratory motile cilium morphology (HP:0005938)9.13177134
4Rhinitis (HP:0012384)7.40758030
5Infertility (HP:0000789)7.33846545
6Chronic bronchitis (HP:0004469)7.28517918
7Abnormal ciliary motility (HP:0012262)7.00594748
8Nasal polyposis (HP:0100582)6.45788743
9Abnormality of the nasal mucosa (HP:0000433)5.30956760
10Male infertility (HP:0003251)5.22279900
11Bronchitis (HP:0012387)4.64033136
12Pancreatic cysts (HP:0001737)4.60094395
13Bronchiectasis (HP:0002110)4.42672795
14Pancreatic fibrosis (HP:0100732)4.27810190
15Nephronophthisis (HP:0000090)4.17852466
16Type II lissencephaly (HP:0007260)3.90796412
17Attenuation of retinal blood vessels (HP:0007843)3.88806167
18Abnormal spermatogenesis (HP:0008669)3.87316965
19True hermaphroditism (HP:0010459)3.75790208
20Congenital stationary night blindness (HP:0007642)3.75718927
21Recurrent otitis media (HP:0000403)3.33003950
22Chronic hepatic failure (HP:0100626)3.27955038
23Abnormality of the renal medulla (HP:0100957)3.11209135
24Recurrent sinusitis (HP:0011108)3.06234618
25Impulsivity (HP:0100710)3.03089332
26Abnormal rod and cone electroretinograms (HP:0008323)3.01879235
27Pendular nystagmus (HP:0012043)2.92618749
28Recurrent bronchitis (HP:0002837)2.87709947
29Lissencephaly (HP:0001339)2.79549032
30Cholecystitis (HP:0001082)2.75898040
31Abnormal gallbladder physiology (HP:0012438)2.75898040
32Tubulointerstitial nephritis (HP:0001970)2.69981849
33Bony spicule pigmentary retinopathy (HP:0007737)2.65735383
34Tubular atrophy (HP:0000092)2.60900212
35Sclerocornea (HP:0000647)2.56048809
36Abolished electroretinogram (ERG) (HP:0000550)2.55897625
37Molar tooth sign on MRI (HP:0002419)2.52639734
38Abnormality of midbrain morphology (HP:0002418)2.52639734
39Renal cortical cysts (HP:0000803)2.46025302
40Tubulointerstitial abnormality (HP:0001969)2.42026311
41Azoospermia (HP:0000027)2.41413433
42Gonadotropin excess (HP:0000837)2.40391253
43Hyperalaninemia (HP:0003348)2.39608040
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39608040
45Abnormality of alanine metabolism (HP:0010916)2.39608040
46Increased corneal curvature (HP:0100692)2.37660518
47Keratoconus (HP:0000563)2.37660518
48Hyperventilation (HP:0002883)2.32678775
49Methylmalonic acidemia (HP:0002912)2.31692832
50Inability to walk (HP:0002540)2.30842532
51Dyschromatopsia (HP:0007641)2.28482842
52Aplasia/Hypoplasia of the spleen (HP:0010451)2.24547964
53Retinal dysplasia (HP:0007973)2.22948964
54Optic nerve hypoplasia (HP:0000609)2.22504285
55Anencephaly (HP:0002323)2.20497959
56Medial flaring of the eyebrow (HP:0010747)2.18929721
57Choroideremia (HP:0001139)2.17366717
58Chorioretinal atrophy (HP:0000533)2.14613396
59Asplenia (HP:0001746)2.14019125
60Severe visual impairment (HP:0001141)2.13962866
61Spastic tetraparesis (HP:0001285)2.13886635
62Pachygyria (HP:0001302)2.13752496
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.08684389
64Gait imbalance (HP:0002141)2.08301242
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06993961
66Progressive cerebellar ataxia (HP:0002073)2.06806257
67Abnormality of the labia minora (HP:0012880)2.06255924
68Supernumerary spleens (HP:0009799)2.05467687
69Tubulointerstitial fibrosis (HP:0005576)2.04191748
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02683408
71Optic disc pallor (HP:0000543)2.01574739
72Congenital primary aphakia (HP:0007707)2.00873901
73Occipital encephalocele (HP:0002085)2.00018467
74Absent/shortened dynein arms (HP:0200106)13.2518602
75Dynein arm defect of respiratory motile cilia (HP:0012255)13.2518602
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9024953
77Nephrogenic diabetes insipidus (HP:0009806)1.98873977
78Progressive inability to walk (HP:0002505)1.98314084
79Decreased central vision (HP:0007663)1.96836263
80Congenital sensorineural hearing impairment (HP:0008527)1.96817907
81Aplasia/Hypoplasia of the uvula (HP:0010293)1.95645456
82Hyperglycinemia (HP:0002154)1.95157342
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.91135493
84Febrile seizures (HP:0002373)1.90001342
85Genital tract atresia (HP:0001827)1.88741326
86Male pseudohermaphroditism (HP:0000037)1.86451516
87Hemorrhage of the eye (HP:0011885)1.86319768
88Decreased circulating renin level (HP:0003351)1.85918171
89Gaze-evoked nystagmus (HP:0000640)1.85716336
90Abnormality of macular pigmentation (HP:0008002)1.84485499
91Congenital malformation of the right heart (HP:0011723)1.84061959
92Double outlet right ventricle (HP:0001719)1.84061959
93Methylmalonic aciduria (HP:0012120)1.82681657
94Heterotopia (HP:0002282)1.82040584
95Polydipsia (HP:0001959)1.81620049
96Abnormal drinking behavior (HP:0030082)1.81620049
97Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80576699
98Ketosis (HP:0001946)1.79999751
99Neurofibrillary tangles (HP:0002185)1.79864052
100Disproportionate short-trunk short stature (HP:0003521)1.78188849
101Preaxial hand polydactyly (HP:0001177)1.75403621
102Hyperglycinuria (HP:0003108)1.74987130
103Abnormality of the ileum (HP:0001549)1.74967697
104Furrowed tongue (HP:0000221)1.73985985
105Vaginal atresia (HP:0000148)1.73848507
106Postaxial foot polydactyly (HP:0001830)1.73167199
107Stage 5 chronic kidney disease (HP:0003774)1.72842723
108Meckel diverticulum (HP:0002245)1.70272425
109Small hand (HP:0200055)1.70085209
110Genetic anticipation (HP:0003743)1.69582031
111Dandy-Walker malformation (HP:0001305)1.68528598
112Sloping forehead (HP:0000340)1.68190970
113Bile duct proliferation (HP:0001408)1.67975587
114Abnormal biliary tract physiology (HP:0012439)1.67975587
115Hypothermia (HP:0002045)1.67589939
116Increased CSF lactate (HP:0002490)1.64952288
117Decreased electroretinogram (ERG) amplitude (HP:0000654)1.64842297
118Abnormality of serine family amino acid metabolism (HP:0010894)1.64193002
119Abnormality of glycine metabolism (HP:0010895)1.64193002
120Abnormality of renal excretion (HP:0011036)1.62428131
121Congenital hepatic fibrosis (HP:0002612)1.62306939
122Bell-shaped thorax (HP:0001591)1.59564136
123Short ribs (HP:0000773)1.58803043
124Abnormality of the renal cortex (HP:0011035)1.53654802
125Oculomotor apraxia (HP:0000657)1.49078144
126Cerebral inclusion bodies (HP:0100314)1.47057287
127Aplasia/Hypoplasia of the lens (HP:0008063)1.45055942
128Renal dysplasia (HP:0000110)1.44973210
129Bundle branch block (HP:0011710)1.44660661
130Asymmetric septal hypertrophy (HP:0001670)1.44467074
131Easy fatigability (HP:0003388)1.42562162
132Absent epiphyses (HP:0010577)1.42168744
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.42168744
134Exercise-induced myalgia (HP:0003738)1.41823234
135Abnormality of dentin (HP:0010299)1.40673652
136Abnormal urine output (HP:0012590)1.40504259
137Hemiparesis (HP:0001269)1.37711401
138Abnormality of the dental root (HP:0006486)1.37439924
139Taurodontia (HP:0000679)1.37439924
140Abnormality of permanent molar morphology (HP:0011071)1.37439924
141Deformed sella turcica (HP:0002681)1.36437698
142Loss of speech (HP:0002371)1.35776109
143Postaxial hand polydactyly (HP:0001162)1.34539072
144Myoglobinuria (HP:0002913)1.34375301
145Hypercholesterolemia (HP:0003124)1.33940572
146Fibular hypoplasia (HP:0003038)1.33708823
147Abnormality of the neuromuscular junction (HP:0003398)1.33629090
148Fatigable weakness (HP:0003473)1.33629090
149Abnormality of the lower motor neuron (HP:0002366)1.31404945
150Facial cleft (HP:0002006)1.30688113
151Sensory axonal neuropathy (HP:0003390)1.28651599
152Abnormality of the dental pulp (HP:0006479)1.28367475
153Cystic liver disease (HP:0006706)1.28138948
154Cerebellar dysplasia (HP:0007033)1.27273656
155Broad distal phalanx of finger (HP:0009836)1.27009945
156Abnormality of molar morphology (HP:0011070)1.26252774
157Abnormality of molar (HP:0011077)1.26252774
158Short femoral neck (HP:0100864)1.26234588
159Constricted visual fields (HP:0001133)1.23550173
160Rhabdomyolysis (HP:0003201)1.22656085
161Truncal obesity (HP:0001956)1.21440050
162Amyotrophic lateral sclerosis (HP:0007354)1.19138011
163Neoplasm of the heart (HP:0100544)1.18596892
164Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.16641988
165Nephropathy (HP:0000112)1.16380609
166Generalized muscle weakness (HP:0003324)1.16242836
167Polyuria (HP:0000103)1.15111741
168Short thorax (HP:0010306)1.15018341
169Chronic sinusitis (HP:0011109)1.14461034

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.40339782
2PDK37.40339782
3TESK17.28579353
4PRKD35.85419027
5FRK5.23937179
6ICK4.99568580
7PDK24.76512722
8MAP4K23.46522029
9ADRBK23.15370281
10NUAK12.77590069
11INSRR2.72121654
12BMPR1B2.69133688
13GRK12.37636517
14ZAK2.36192740
15PTK2B2.30263340
16TAOK32.25013872
17STK382.14643397
18WNK42.11949711
19STK392.01795609
20TLK11.97526342
21PNCK1.84142094
22MAPK131.81807897
23DYRK1B1.78221414
24NEK21.71371408
25DYRK21.59031405
26MAP3K41.54441639
27DAPK21.49344027
28ACVR1B1.48039092
29MARK11.46004312
30PLK21.42421843
31CASK1.36691733
32OXSR11.30467120
33PDK11.24954937
34TRIM281.23699771
35MAP2K71.17939724
36PAK31.13938685
37ADRBK11.05637117
38TNIK1.04719292
39TXK0.99878691
40DYRK30.97085705
41PRKCE0.95695634
42MKNK20.95058947
43BCKDK0.95037049
44TYRO30.90843114
45MAPK150.87831150
46VRK10.86213824
47EEF2K0.86184140
48PDPK10.86032104
49FGFR20.85354355
50WNK10.78919290
51CSNK1G20.78183998
52RIPK40.77876490
53IKBKB0.76100346
54EPHA40.72161473
55IRAK10.71600543
56PASK0.70795534
57TESK20.70561819
58TIE10.69824097
59CSNK1G10.68963238
60RPS6KA50.68856669
61TTK0.68362649
62CCNB10.68291995
63MKNK10.67564926
64CSNK1G30.67023571
65STK30.66136142
66NME10.61821867
67CHEK20.61338675
68CAMKK20.61229740
69AKT30.61181914
70PINK10.60048698
71PIK3CA0.55280296
72PHKG20.54765715
73PHKG10.54765715
74CAMK1G0.53569775
75CAMK10.53349840
76MST40.52212614
77MUSK0.51896858
78PRKACA0.51482595
79ERBB30.51074634
80NTRK30.51012589
81FER0.50097721
82CSNK1A10.49993187
83CSNK1A1L0.49967023
84MAP2K60.48984628
85STK38L0.47691530
86TEC0.47483226
87NTRK20.46798983
88SIK20.46618618
89CHUK0.45846784
90VRK20.45690883
91PAK10.44773235
92PRKAA20.43809700
93TNK20.43492620
94NLK0.43396185
95IRAK20.40441337
96RPS6KA60.38910550
97BCR0.37919887
98PRKCG0.37730418
99RPS6KA40.37710187
100PRKCI0.37617511
101PLK30.37036806
102CHEK10.36622437
103CDK30.36490531
104MAPKAPK30.36457823
105MAP3K100.34410110
106ITK0.34187872
107LMTK20.34010016
108DYRK1A0.33193226
109PAK40.32512787
110TGFBR10.32461140
111PAK20.32332741
112MARK20.30484607
113MAPKAPK50.29606910
114SGK20.29470317
115MTOR0.28390209
116CAMKK10.26862724
117ATM0.26180487
118PRKAA10.23094483
119ATR0.22120185
120PRKCZ0.19739619
121NEK60.19170370
122WEE10.19116691
123BRSK20.16903258
124CDK150.16757412
125PRKCQ0.14659854
126RPS6KB10.14658267
127PLK40.14489927
128CDK180.13957719
129BRAF0.13795196
130PLK10.13490386
131CDK11A0.12840421
132STK100.11500055
133BRSK10.11279989
134RPS6KA10.10475965
135CDK140.08301337
136CDC70.08237754
137CSF1R0.07578753
138PRKG20.07480376
139GSK3B0.07180949
140CSNK2A10.06392164
141CLK10.06365750
142STK110.05263712
143PIM10.04985136
144CDK60.04890114
145PAK60.04227768
146CAMK2A0.03475718
147CDK20.03210901
148MARK30.02749466
149CDK10.02606133
150PRKCD0.02483409
151MAPK80.02002648
152AURKA0.01990225
153TRIB30.01862500
154CSNK1D0.01637861
155PRKACG0.01162492
156PRKG10.01007988
157PRKCB0.00567386
158CDK40.00320238
159PRKCA0.00036743
160PDGFRB-0.0419240
161WNK3-0.0417970
162MAP3K5-0.0369554
163ZAP70-0.0364999
164TAOK1-0.0326836
165EGFR-0.0286417
166RPS6KA3-0.0281103
167MAP3K1-0.0125211
168EPHB1-0.0066966
169PKN1-0.0027367
170CSNK2A2-0.0025606

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.93833002
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.34377387
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.34692380
4Vitamin B6 metabolism_Homo sapiens_hsa007503.31756622
5Linoleic acid metabolism_Homo sapiens_hsa005913.24350828
6Pyruvate metabolism_Homo sapiens_hsa006203.12666211
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.08616028
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.83237358
9Butanoate metabolism_Homo sapiens_hsa006502.63298362
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.56163344
11Phototransduction_Homo sapiens_hsa047442.55438126
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.51028507
13Glucagon signaling pathway_Homo sapiens_hsa049222.50988733
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38064161
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.35629511
16Propanoate metabolism_Homo sapiens_hsa006402.32236508
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.29462568
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.26118226
19Nitrogen metabolism_Homo sapiens_hsa009102.24070777
20Basal transcription factors_Homo sapiens_hsa030222.19765338
21Caffeine metabolism_Homo sapiens_hsa002322.19075932
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.04098911
23Glycerolipid metabolism_Homo sapiens_hsa005611.98387408
24Selenocompound metabolism_Homo sapiens_hsa004501.93065756
25PPAR signaling pathway_Homo sapiens_hsa033201.93001751
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91070176
27Nicotine addiction_Homo sapiens_hsa050331.90040513
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.86629908
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.86176504
30Tryptophan metabolism_Homo sapiens_hsa003801.85056988
31RNA polymerase_Homo sapiens_hsa030201.81082802
32Oxidative phosphorylation_Homo sapiens_hsa001901.77550469
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.74241774
34Fructose and mannose metabolism_Homo sapiens_hsa000511.71046721
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66903712
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63894842
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62926448
38Fat digestion and absorption_Homo sapiens_hsa049751.60897231
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59652926
40Olfactory transduction_Homo sapiens_hsa047401.59572062
41Oocyte meiosis_Homo sapiens_hsa041141.58684285
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57083994
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55351006
44Amphetamine addiction_Homo sapiens_hsa050311.54385720
45Ether lipid metabolism_Homo sapiens_hsa005651.54099187
46Mineral absorption_Homo sapiens_hsa049781.52965636
47Fatty acid metabolism_Homo sapiens_hsa012121.49349435
48Fatty acid degradation_Homo sapiens_hsa000711.48987265
49Dorso-ventral axis formation_Homo sapiens_hsa043201.46297954
50Pentose phosphate pathway_Homo sapiens_hsa000301.42852140
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.42180246
52Homologous recombination_Homo sapiens_hsa034401.31512699
53Parkinsons disease_Homo sapiens_hsa050121.27948467
54Cardiac muscle contraction_Homo sapiens_hsa042601.26224997
55Carbon metabolism_Homo sapiens_hsa012001.26079946
56Protein export_Homo sapiens_hsa030601.25100074
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.20202990
58Peroxisome_Homo sapiens_hsa041461.19606735
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19197512
60Glycosaminoglycan degradation_Homo sapiens_hsa005311.18447400
61One carbon pool by folate_Homo sapiens_hsa006701.16548300
62Retinol metabolism_Homo sapiens_hsa008301.15479446
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15216566
64Fanconi anemia pathway_Homo sapiens_hsa034601.13969831
65RNA degradation_Homo sapiens_hsa030181.11590554
66Antigen processing and presentation_Homo sapiens_hsa046121.06777058
67Hedgehog signaling pathway_Homo sapiens_hsa043401.06672647
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.05797668
69Renin secretion_Homo sapiens_hsa049241.03030399
70Morphine addiction_Homo sapiens_hsa050321.01250145
71Glutathione metabolism_Homo sapiens_hsa004801.00702933
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.98363739
73Purine metabolism_Homo sapiens_hsa002300.97321798
74mRNA surveillance pathway_Homo sapiens_hsa030150.96608480
75Sulfur relay system_Homo sapiens_hsa041220.95723989
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95493974
77beta-Alanine metabolism_Homo sapiens_hsa004100.92162986
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.92148165
79Serotonergic synapse_Homo sapiens_hsa047260.91718953
80Collecting duct acid secretion_Homo sapiens_hsa049660.89716124
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89500744
82Arachidonic acid metabolism_Homo sapiens_hsa005900.87443037
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85209164
84Insulin secretion_Homo sapiens_hsa049110.84676720
85Regulation of autophagy_Homo sapiens_hsa041400.82171955
86RNA transport_Homo sapiens_hsa030130.80012086
87Huntingtons disease_Homo sapiens_hsa050160.79802520
88Glutamatergic synapse_Homo sapiens_hsa047240.78409890
89Estrogen signaling pathway_Homo sapiens_hsa049150.78008915
90GABAergic synapse_Homo sapiens_hsa047270.77253030
91Long-term potentiation_Homo sapiens_hsa047200.75578534
92Ovarian steroidogenesis_Homo sapiens_hsa049130.75039072
93Chemical carcinogenesis_Homo sapiens_hsa052040.74875438
94Biosynthesis of amino acids_Homo sapiens_hsa012300.74615192
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74056453
96Thyroid hormone synthesis_Homo sapiens_hsa049180.73907962
97Bile secretion_Homo sapiens_hsa049760.73760518
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72794098
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70324299
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70009016
101Histidine metabolism_Homo sapiens_hsa003400.68760067
102Steroid biosynthesis_Homo sapiens_hsa001000.68258848
103Alzheimers disease_Homo sapiens_hsa050100.66420005
104Asthma_Homo sapiens_hsa053100.66202661
105Systemic lupus erythematosus_Homo sapiens_hsa053220.62909345
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.62049252
107Legionellosis_Homo sapiens_hsa051340.59056845
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59032598
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58202878
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57185828
111Pancreatic secretion_Homo sapiens_hsa049720.55093152
112Circadian rhythm_Homo sapiens_hsa047100.55030695
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55015361
114Renin-angiotensin system_Homo sapiens_hsa046140.54133650
115Arginine and proline metabolism_Homo sapiens_hsa003300.52788731
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52771228
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52408863
118Type I diabetes mellitus_Homo sapiens_hsa049400.52189947
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52123620
120Salivary secretion_Homo sapiens_hsa049700.52005401
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50441408
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50179588
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.49551729
124AMPK signaling pathway_Homo sapiens_hsa041520.49509448
125Endocytosis_Homo sapiens_hsa041440.48646304
126ABC transporters_Homo sapiens_hsa020100.48078873
127Synaptic vesicle cycle_Homo sapiens_hsa047210.47160525
128Protein digestion and absorption_Homo sapiens_hsa049740.46857142
129Non-homologous end-joining_Homo sapiens_hsa034500.45973837
130Calcium signaling pathway_Homo sapiens_hsa040200.44410588
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42048118
132Gastric acid secretion_Homo sapiens_hsa049710.40583293
133VEGF signaling pathway_Homo sapiens_hsa043700.38436110
134Long-term depression_Homo sapiens_hsa047300.37177601
135Alcoholism_Homo sapiens_hsa050340.37071190
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36904726
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35167403
138Inositol phosphate metabolism_Homo sapiens_hsa005620.33782451
139Lysine degradation_Homo sapiens_hsa003100.32707402
140cAMP signaling pathway_Homo sapiens_hsa040240.32658818
141Metabolic pathways_Homo sapiens_hsa011000.32057934
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.31929824
143Allograft rejection_Homo sapiens_hsa053300.31103015
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30374989
145Pyrimidine metabolism_Homo sapiens_hsa002400.30236098
146Graft-versus-host disease_Homo sapiens_hsa053320.30132300
147Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27989788
148Cocaine addiction_Homo sapiens_hsa050300.25690877
149Taste transduction_Homo sapiens_hsa047420.24185864
150Circadian entrainment_Homo sapiens_hsa047130.23794904
151Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23047940
152Sulfur metabolism_Homo sapiens_hsa009200.22740989
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19601755
154HIF-1 signaling pathway_Homo sapiens_hsa040660.14231946
155Basal cell carcinoma_Homo sapiens_hsa052170.14016910
156B cell receptor signaling pathway_Homo sapiens_hsa046620.12551073
157Wnt signaling pathway_Homo sapiens_hsa043100.10912895
158Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.09039151
159Salmonella infection_Homo sapiens_hsa051320.08703075
160Insulin resistance_Homo sapiens_hsa049310.08124444
161Type II diabetes mellitus_Homo sapiens_hsa049300.07763608

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