SPATA22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA synthesis involved in DNA repair (GO:0000731)9.71541549
2regulation of meiosis I (GO:0060631)8.83316322
3* meiotic cell cycle process (GO:1903046)8.71088233
4sister chromatid cohesion (GO:0007062)8.63221022
5reciprocal meiotic recombination (GO:0007131)7.51570675
6reciprocal DNA recombination (GO:0035825)7.51570675
7resolution of meiotic recombination intermediates (GO:0000712)7.04762107
8gene silencing by RNA (GO:0031047)6.18917275
9histone H3-K9 demethylation (GO:0033169)5.96922106
10meiotic chromosome segregation (GO:0045132)5.92682040
11female gamete generation (GO:0007292)5.32674319
12positive regulation of meiosis (GO:0045836)5.14819750
13histone H3-K36 demethylation (GO:0070544)5.02074150
14mitotic sister chromatid cohesion (GO:0007064)4.85421858
15positive regulation of meiotic cell cycle (GO:0051446)4.82040854
16superoxide anion generation (GO:0042554)4.58264542
17DNA alkylation (GO:0006305)4.58042106
18DNA methylation (GO:0006306)4.58042106
19indole-containing compound catabolic process (GO:0042436)4.57754087
20indolalkylamine catabolic process (GO:0046218)4.57754087
21tryptophan catabolic process (GO:0006569)4.57754087
22tryptophan metabolic process (GO:0006568)4.38512944
23protein localization to chromosome (GO:0034502)4.35521715
24regulation of DNA endoreduplication (GO:0032875)4.26488362
25amine catabolic process (GO:0009310)4.21164354
26cellular biogenic amine catabolic process (GO:0042402)4.21164354
27negative regulation of inclusion body assembly (GO:0090084)4.14659483
28meiotic cell cycle (GO:0051321)4.14478283
29cilium or flagellum-dependent cell motility (GO:0001539)3.93657906
30NAD biosynthetic process (GO:0009435)3.91942060
31histone exchange (GO:0043486)3.90916803
32regulation of histone H3-K9 methylation (GO:0051570)3.90889992
33oogenesis (GO:0048477)3.89977599
34positive regulation of response to oxidative stress (GO:1902884)3.80084100
35positive regulation of cellular response to oxidative stress (GO:1900409)3.80084100
36aromatic amino acid family catabolic process (GO:0009074)3.78044775
37* chromosome organization (GO:0051276)3.75754925
38spermatid development (GO:0007286)3.70842134
39negative regulation of gene silencing (GO:0060969)3.69889687
40purine ribonucleotide transport (GO:0015868)3.69125189
41gene silencing (GO:0016458)3.66495918
42binding of sperm to zona pellucida (GO:0007339)3.66087580
43adenosine metabolic process (GO:0046085)3.61622932
44histone H2A acetylation (GO:0043968)3.61404018
45attachment of spindle microtubules to kinetochore (GO:0008608)3.57793755
46indolalkylamine metabolic process (GO:0006586)3.53954797
47regulation of meiosis (GO:0040020)3.52420841
48DNA packaging (GO:0006323)3.51408959
49purine nucleotide transport (GO:0015865)3.49874141
50negative regulation of meiosis (GO:0045835)3.47623135
51glycerophospholipid catabolic process (GO:0046475)3.46634303
52nucleotide transmembrane transport (GO:1901679)3.42614067
53piRNA metabolic process (GO:0034587)3.41215027
54genitalia morphogenesis (GO:0035112)3.40780340
55regulation of transcription from RNA polymerase I promoter (GO:0006356)3.39814347
56auditory receptor cell stereocilium organization (GO:0060088)3.34940717
57nuclear division (GO:0000280)3.33769447
58centriole assembly (GO:0098534)3.32861953
59negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.31467559
60acrosome assembly (GO:0001675)3.30568095
61germ cell development (GO:0007281)3.29604952
62proteasome assembly (GO:0043248)3.29548048
63adenine nucleotide transport (GO:0051503)3.28564369
64DNA methylation or demethylation (GO:0044728)3.26590402
65DNA methylation involved in gamete generation (GO:0043046)3.25761169
66mitotic chromosome condensation (GO:0007076)3.23337617
67male gamete generation (GO:0048232)3.22328712
68spermatogenesis (GO:0007283)3.21523528
69histone lysine demethylation (GO:0070076)3.20033461
70* regulation of meiotic cell cycle (GO:0051445)3.16678012
71kynurenine metabolic process (GO:0070189)3.15599203
72omega-hydroxylase P450 pathway (GO:0097267)3.14348708
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.13276462
74regulation of activation of Janus kinase activity (GO:0010533)3.12761617
75positive regulation of cellular amine metabolic process (GO:0033240)3.11695731
76organelle fission (GO:0048285)3.10378423
77histone demethylation (GO:0016577)3.09874056
78androgen biosynthetic process (GO:0006702)3.09622186
79* DNA biosynthetic process (GO:0071897)3.08925503
80* gamete generation (GO:0007276)3.06885273
81microtubule depolymerization (GO:0007019)3.05035691
82preassembly of GPI anchor in ER membrane (GO:0016254)3.04989643
83negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.04014275
84motile cilium assembly (GO:0044458)3.02335180
85sex differentiation (GO:0007548)3.00112119
86mitotic spindle assembly checkpoint (GO:0007094)2.97988355
87interkinetic nuclear migration (GO:0022027)2.94579248
88nuclear pore complex assembly (GO:0051292)2.94206819
89histone H4-K12 acetylation (GO:0043983)2.93527939
90cellular process involved in reproduction in multicellular organism (GO:0022412)2.93322046
91L-phenylalanine catabolic process (GO:0006559)2.91876088
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.91876088
93* fertilization (GO:0009566)2.91686172
94spindle assembly checkpoint (GO:0071173)2.89697432
95presynaptic membrane assembly (GO:0097105)2.89603111
96nicotinamide nucleotide biosynthetic process (GO:0019359)2.88727435
97pyridine nucleotide biosynthetic process (GO:0019363)2.88727435
98G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.87862111
99DNA integration (GO:0015074)2.86849607
100long-chain fatty acid biosynthetic process (GO:0042759)2.86377714
101keratinocyte development (GO:0003334)2.85561040
102protein dealkylation (GO:0008214)2.84194241
103protein demethylation (GO:0006482)2.84194241
104sperm-egg recognition (GO:0035036)2.84131605
105pyrimidine-containing compound transmembrane transport (GO:0072531)2.84004450
106GPI anchor biosynthetic process (GO:0006506)2.83448497
107aromatic amino acid family metabolic process (GO:0009072)2.82916304
108negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.80212554
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80212554
110negative regulation of mitotic sister chromatid segregation (GO:0033048)2.80212554
111negative regulation of mitotic sister chromatid separation (GO:2000816)2.80212554
112negative regulation of sister chromatid segregation (GO:0033046)2.80212554
113GPI anchor metabolic process (GO:0006505)2.78641500
114mitotic spindle checkpoint (GO:0071174)2.76676536
115negative regulation of DNA-dependent DNA replication (GO:2000104)2.75624713
116positive regulation of cellular amide metabolic process (GO:0034250)2.72019602
117embryonic body morphogenesis (GO:0010172)2.71913456
118blood coagulation, intrinsic pathway (GO:0007597)2.71704881
119negative regulation of chromosome segregation (GO:0051985)2.70451304
120detection of bacterium (GO:0016045)2.69012817
121negative regulation of meiotic cell cycle (GO:0051447)2.68205290
122negative regulation of lipase activity (GO:0060192)2.68142098
123regulation of microtubule-based movement (GO:0060632)2.67790539
124axon ensheathment in central nervous system (GO:0032291)2.64063667
125central nervous system myelination (GO:0022010)2.64063667
126startle response (GO:0001964)2.63585869
127acrosome reaction (GO:0007340)2.62420991
128linoleic acid metabolic process (GO:0043651)2.61038395
129nucleotide transport (GO:0006862)2.60793759
130DNA modification (GO:0006304)2.60526965
131CENP-A containing nucleosome assembly (GO:0034080)2.59492551
132androgen metabolic process (GO:0008209)2.59091214
133regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.58211850
134female gonad development (GO:0008585)2.56772765
135presynaptic membrane organization (GO:0097090)2.56546513
136regulation of sister chromatid segregation (GO:0033045)2.55572795
137regulation of mitotic sister chromatid separation (GO:0010965)2.55572795
138regulation of mitotic sister chromatid segregation (GO:0033047)2.55572795
139uronic acid metabolic process (GO:0006063)2.55261042
140glucuronate metabolic process (GO:0019585)2.55261042
141positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.55122134
142cell differentiation involved in metanephros development (GO:0072202)2.55098041
143polyol transport (GO:0015791)2.54789986
144spindle checkpoint (GO:0031577)2.54240688
145chromatin remodeling at centromere (GO:0031055)2.53812103
146L-phenylalanine metabolic process (GO:0006558)2.53167808
147erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.53167808
148mesenchymal cell differentiation involved in renal system development (GO:2001012)2.52858935
149mesenchymal cell differentiation involved in kidney development (GO:0072161)2.52858935
150protein refolding (GO:0042026)2.52296159
151inner ear receptor stereocilium organization (GO:0060122)2.50773735
152T-helper cell differentiation (GO:0042093)2.49805370
153CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.49805370
154very-low-density lipoprotein particle assembly (GO:0034379)2.47906124
155multicellular organism reproduction (GO:0032504)2.47168946
156developmental pigmentation (GO:0048066)2.47137249
157regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.47135349
158regulation of mitotic metaphase/anaphase transition (GO:0030071)2.47135349
159detection of other organism (GO:0098543)2.47069900
160sperm motility (GO:0030317)2.47022250
161regulation of chromosome segregation (GO:0051983)2.46949129
162superoxide metabolic process (GO:0006801)2.46113252
163axonemal dynein complex assembly (GO:0070286)2.44968282
164nuclear pore organization (GO:0006999)2.44801556
165fatty acid elongation (GO:0030497)2.44007217
166negative regulation of nuclear division (GO:0051784)2.43901470
167cellular response to ATP (GO:0071318)2.42473150
168regulation of interleukin-8 secretion (GO:2000482)2.41580956
169cellular response to exogenous dsRNA (GO:0071360)2.40932088
170epithelial cilium movement (GO:0003351)2.39856824
171water-soluble vitamin biosynthetic process (GO:0042364)2.38962796
172regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.38751887
173indole-containing compound metabolic process (GO:0042430)2.37637691
174regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.34734321
175positive regulation of icosanoid secretion (GO:0032305)2.34463370
176male meiosis (GO:0007140)2.34149439
177hepatocyte differentiation (GO:0070365)2.31728012
178regulation of timing of cell differentiation (GO:0048505)2.30812446
179negative regulation of myoblast differentiation (GO:0045662)2.30455473
180regulation of fibrinolysis (GO:0051917)2.30300687
181opioid receptor signaling pathway (GO:0038003)2.29912282
182purinergic nucleotide receptor signaling pathway (GO:0035590)2.29764923
183ceramide catabolic process (GO:0046514)2.27366420
184amino sugar catabolic process (GO:0046348)2.27203146
185retina layer formation (GO:0010842)2.26994017
186response to folic acid (GO:0051593)2.25915249
187aldehyde catabolic process (GO:0046185)2.25890844
188tyrosine metabolic process (GO:0006570)2.25845814
189CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.25247838
190DNA double-strand break processing (GO:0000729)2.24763544
191synaptonemal complex assembly (GO:0007130)15.7637234
192male meiosis I (GO:0007141)15.6273676
193* chromosome organization involved in meiosis (GO:0070192)15.1682871
194* synapsis (GO:0007129)14.6176010
195synaptonemal complex organization (GO:0070193)14.2144548
196meiosis I (GO:0007127)12.6372979
197meiotic nuclear division (GO:0007126)11.2646175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.63525243
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.58029978
3GBX2_23144817_ChIP-Seq_PC3_Human3.23600945
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.08255638
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.06645128
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.90215370
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.89883461
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.79221132
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75628232
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.70505828
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64460814
12E2F7_22180533_ChIP-Seq_HELA_Human2.58539292
13SUZ12_27294783_Chip-Seq_NPCs_Mouse2.57155147
14PCGF2_27294783_Chip-Seq_NPCs_Mouse2.51688236
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.49627426
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37373401
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24381253
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.23891065
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21111785
20EZH2_22144423_ChIP-Seq_EOC_Human2.20575757
21EZH2_27294783_Chip-Seq_NPCs_Mouse2.19545535
22CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.19474608
23TAF15_26573619_Chip-Seq_HEK293_Human2.18095073
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.10893245
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.10893245
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.10893245
27EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.07964723
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.02266547
29CBX2_27304074_Chip-Seq_ESCs_Mouse2.00640708
30IRF1_19129219_ChIP-ChIP_H3396_Human2.00257278
31EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.99376132
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.93532494
33STAT3_18555785_Chip-Seq_ESCs_Mouse1.93184564
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.92851930
35P53_22387025_ChIP-Seq_ESCs_Mouse1.91697867
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90139778
37SUZ12_18555785_Chip-Seq_ESCs_Mouse1.90033594
38NMYC_18555785_Chip-Seq_ESCs_Mouse1.87583432
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.87151895
40RUNX1_27457419_Chip-Seq_LIVER_Mouse1.86589579
41E2F1_18555785_Chip-Seq_ESCs_Mouse1.85926254
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.81618430
43P300_18555785_Chip-Seq_ESCs_Mouse1.81291225
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79404607
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78094883
46PU1_27457419_Chip-Seq_LIVER_Mouse1.77796750
47OCT4_18555785_Chip-Seq_ESCs_Mouse1.77742510
48CMYC_18555785_Chip-Seq_ESCs_Mouse1.74709486
49RUNX1_26923725_Chip-Seq_HPCs_Mouse1.74226980
50ZNF274_21170338_ChIP-Seq_K562_Hela1.73724344
51ZFX_18555785_Chip-Seq_ESCs_Mouse1.71320663
52KLF4_18555785_Chip-Seq_ESCs_Mouse1.70085368
53SOX2_18555785_Chip-Seq_ESCs_Mouse1.69695906
54VDR_22108803_ChIP-Seq_LS180_Human1.68169013
55P300_19829295_ChIP-Seq_ESCs_Human1.67570159
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.66976949
57DCP1A_22483619_ChIP-Seq_HELA_Human1.65568299
58ESRRB_18555785_Chip-Seq_ESCs_Mouse1.64306490
59SMAD1_18555785_Chip-Seq_ESCs_Mouse1.63947292
60* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63065778
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.62191469
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.61323973
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61040459
64BCAT_22108803_ChIP-Seq_LS180_Human1.57728816
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54480473
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.54409981
67OCT4_21477851_ChIP-Seq_ESCs_Mouse1.52548595
68CTCF_18555785_Chip-Seq_ESCs_Mouse1.50076510
69RNF2_27304074_Chip-Seq_NSC_Mouse1.49713199
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49516428
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.48389244
72SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.45250032
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42921178
74* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.42511550
75HTT_18923047_ChIP-ChIP_STHdh_Human1.40386615
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39427713
77ER_23166858_ChIP-Seq_MCF-7_Human1.39387699
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.38645433
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.37298940
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36034474
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35955086
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34856078
83KAP1_22055183_ChIP-Seq_ESCs_Mouse1.34334687
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33604264
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30465679
86FUS_26573619_Chip-Seq_HEK293_Human1.30295753
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.28695259
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28352615
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28322800
90KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28320272
91* ERA_21632823_ChIP-Seq_H3396_Human1.28277886
92KDM2B_26808549_Chip-Seq_REH_Human1.26923678
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26809789
94TP53_22573176_ChIP-Seq_HFKS_Human1.24446843
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24435026
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23269069
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22959677
98SMAD4_21799915_ChIP-Seq_A2780_Human1.22367720
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22258315
100CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22226596
101SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20836049
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20500971
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.20207002
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19167042
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.18783504
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17820865
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17820865
108YY1_21170310_ChIP-Seq_MESCs_Mouse1.17674725
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16180411
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15563653
111MYC_18940864_ChIP-ChIP_HL60_Human1.14639444
112GATA3_26560356_Chip-Seq_TH1_Human1.13835322
113IGF1R_20145208_ChIP-Seq_DFB_Human1.13490596
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13217834
115TP63_19390658_ChIP-ChIP_HaCaT_Human1.12135636
116TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11766564
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10428104
118IRF8_21731497_ChIP-ChIP_J774_Mouse1.09986898
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.09384882
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09248893
121AR_25329375_ChIP-Seq_VCAP_Human1.09110313
122FOXM1_23109430_ChIP-Seq_U2OS_Human1.08036933
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07869727
124SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06026055
125TCF4_23295773_ChIP-Seq_U87_Human1.05696739
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05418785
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05168369
128HOXB7_26014856_ChIP-Seq_BT474_Human1.04497477
129STAT1_17558387_ChIP-Seq_HELA_Human1.04496648
130TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.04466219
131GABP_19822575_ChIP-Seq_HepG2_Human1.04288646
132SMAD_19615063_ChIP-ChIP_OVARY_Human1.04010112
133VDR_23849224_ChIP-Seq_CD4+_Human1.03513008
134MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03287030
135NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01746066
136RUNX2_22187159_ChIP-Seq_PCA_Human1.00380224
137FOXH1_21741376_ChIP-Seq_EPCs_Human1.00343753
138FOXA1_25329375_ChIP-Seq_VCAP_Human1.00069130
139FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00069130
140TP53_18474530_ChIP-ChIP_U2OS_Human0.99736831
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99414990
142PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98938211
143FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98823492
144TTF2_22483619_ChIP-Seq_HELA_Human0.98757086
145GABP_17652178_ChIP-ChIP_JURKAT_Human0.98539822
146JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97682702
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97452595
148BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97416003
149MYC_19829295_ChIP-Seq_ESCs_Human0.97288298
150KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97126507
151STAT3_23295773_ChIP-Seq_U87_Human0.96980045
152DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96940908
153SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96814394
154WDR5_24793694_ChIP-Seq_LNCAP_Human0.95460614
155RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94492191
156AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94483477
157ETV1_20927104_ChIP-Seq_GIST48_Human0.93023440
158E2F1_17053090_ChIP-ChIP_MCF-7_Human0.92681278
159PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90058624
160TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85787582
161RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85653564
162SOX2_21211035_ChIP-Seq_LN229_Human0.85352236
163EWS_26573619_Chip-Seq_HEK293_Human0.84349647
164PRDM14_20953172_ChIP-Seq_ESCs_Human0.84262137
165ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84259133
166GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83174975
167SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82510212
168PHF8_20622853_ChIP-Seq_HELA_Human0.81542533
169HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81324445
170SMC4_20622854_ChIP-Seq_HELA_Human0.81193339
171E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80570081
172CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78181584

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001145_abnormal_male_reproductive4.15783686
2MP0002160_abnormal_reproductive_system4.05270902
3MP0000653_abnormal_sex_gland3.84145670
4MP0001188_hyperpigmentation3.61393588
5MP0002139_abnormal_hepatobiliary_system3.51339853
6MP0004381_abnormal_hair_follicle3.40552005
7MP0006292_abnormal_olfactory_placode3.12266536
8MP0003136_yellow_coat_color3.10712433
9MP0000566_synostosis2.94329398
10MP0005085_abnormal_gallbladder_physiolo2.80874392
11MP0003941_abnormal_skin_development2.69469417
12MP0002138_abnormal_hepatobiliary_system2.65201061
13MP0001119_abnormal_female_reproductive2.62891106
14MP0008004_abnormal_stomach_pH2.59159041
15MP0002102_abnormal_ear_morphology2.58466141
16MP0005389_reproductive_system_phenotype2.54981812
17MP0005171_absent_coat_pigmentation2.51641348
18MP0005409_darkened_coat_color2.43365241
19MP0002161_abnormal_fertility/fecundity2.37546280
20MP0009697_abnormal_copulation2.29965746
21MP0002277_abnormal_respiratory_mucosa2.28394124
22MP0000678_abnormal_parathyroid_gland2.21397464
23MP0003699_abnormal_female_reproductive2.20156826
24MP0003195_calcinosis2.12032236
25MP0005365_abnormal_bile_salt2.11470294
26MP0009379_abnormal_foot_pigmentation2.10275599
27MP0005451_abnormal_body_composition2.09227508
28MP0003693_abnormal_embryo_hatching2.01134723
29MP0008260_abnormal_autophagy2.01003971
30MP0010094_abnormal_chromosome_stability2.00630560
31MP0005360_urolithiasis1.88301133
32MP0008875_abnormal_xenobiotic_pharmacok1.87350906
33MP0004019_abnormal_vitamin_homeostasis1.85789794
34MP0003724_increased_susceptibility_to1.84632669
35MP0005410_abnormal_fertilization1.82152750
36MP0002132_abnormal_respiratory_system1.78700334
37MP0008007_abnormal_cellular_replicative1.73142978
38MP0008995_early_reproductive_senescence1.70891388
39MP0001486_abnormal_startle_reflex1.65758080
40MP0005075_abnormal_melanosome_morpholog1.64306589
41MP0003646_muscle_fatigue1.62423616
42MP0008789_abnormal_olfactory_epithelium1.59801339
43MP0004147_increased_porphyrin_level1.57674870
44MP0004742_abnormal_vestibular_system1.57537001
45MP0002876_abnormal_thyroid_physiology1.55149849
46MP0008057_abnormal_DNA_replication1.53712720
47MP0005379_endocrine/exocrine_gland_phen1.53184259
48MP0003252_abnormal_bile_duct1.51493255
49MP0000026_abnormal_inner_ear1.51460752
50MP0003011_delayed_dark_adaptation1.48233823
51MP0002638_abnormal_pupillary_reflex1.46353039
52MP0003111_abnormal_nucleus_morphology1.45812340
53MP0002148_abnormal_hypersensitivity_rea1.45785170
54MP0001986_abnormal_taste_sensitivity1.44395790
55MP0001661_extended_life_span1.42998390
56MP0000015_abnormal_ear_pigmentation1.35806197
57MP0003880_abnormal_central_pattern1.33107132
58MP0010386_abnormal_urinary_bladder1.32925972
59MP0002163_abnormal_gland_morphology1.30944339
60MP0003077_abnormal_cell_cycle1.29586454
61MP0005647_abnormal_sex_gland1.27945242
62MP0003718_maternal_effect1.25463702
63MP0000569_abnormal_digit_pigmentation1.24654508
64MP0004142_abnormal_muscle_tone1.22830084
65MP0008058_abnormal_DNA_repair1.22364618
66MP0005423_abnormal_somatic_nervous1.22098512
67MP0005174_abnormal_tail_pigmentation1.20862223
68MP0009764_decreased_sensitivity_to1.20661888
69MP0010307_abnormal_tumor_latency1.19245132
70MP0001984_abnormal_olfaction1.17863492
71MP0000427_abnormal_hair_cycle1.14610801
72MP0003950_abnormal_plasma_membrane1.14428336
73MP0003123_paternal_imprinting1.13451762
74MP0008877_abnormal_DNA_methylation1.11568152
75MP0001963_abnormal_hearing_physiology1.09502947
76MP0005551_abnormal_eye_electrophysiolog1.07504579
77MP0010678_abnormal_skin_adnexa1.07329307
78MP0005671_abnormal_response_to1.03833564
79MP0005394_taste/olfaction_phenotype1.01797842
80MP0005499_abnormal_olfactory_system1.01797842
81MP0002419_abnormal_innate_immunity1.00725344
82MP0009785_altered_susceptibility_to0.99613190
83MP0000613_abnormal_salivary_gland0.98876294
84MP0006276_abnormal_autonomic_nervous0.97857556
85MP0003868_abnormal_feces_composition0.96033211
86MP0010030_abnormal_orbit_morphology0.93308743
87MP0001730_embryonic_growth_arrest0.93230493
88MP0001764_abnormal_homeostasis0.92501035
89MP0005408_hypopigmentation0.91849106
90MP0003183_abnormal_peptide_metabolism0.91736073
91MP0010368_abnormal_lymphatic_system0.90160495
92MP0001790_abnormal_immune_system0.89968843
93MP0005387_immune_system_phenotype0.89968843
94MP0000383_abnormal_hair_follicle0.87981962
95MP0001835_abnormal_antigen_presentation0.87318767
96MP0005646_abnormal_pituitary_gland0.86614387
97MP0006035_abnormal_mitochondrial_morpho0.86449156
98MP0001346_abnormal_lacrimal_gland0.84849657
99MP0003786_premature_aging0.84713390
100MP0010329_abnormal_lipoprotein_level0.84464817
101MP0003698_abnormal_male_reproductive0.84083700
102MP0005670_abnormal_white_adipose0.84053171
103MP0004782_abnormal_surfactant_physiolog0.83475238
104MP0001485_abnormal_pinna_reflex0.82642061
105MP0002095_abnormal_skin_pigmentation0.82065945
106MP0004957_abnormal_blastocyst_morpholog0.81645432
107MP0005000_abnormal_immune_tolerance0.80025650
108MP0001502_abnormal_circadian_rhythm0.79018011
109MP0005645_abnormal_hypothalamus_physiol0.78240936
110MP0005025_abnormal_response_to0.77856782
111MP0000358_abnormal_cell_content/0.77148198
112MP0002249_abnormal_larynx_morphology0.76433085
113MP0006082_CNS_inflammation0.76430530
114MP0000920_abnormal_myelination0.76249267
115MP0002938_white_spotting0.75798432
116MP0003879_abnormal_hair_cell0.75290994
117MP0000372_irregular_coat_pigmentation0.75116399
118MP0002084_abnormal_developmental_patter0.74531602
119MP0002098_abnormal_vibrissa_morphology0.74522154
120MP0005058_abnormal_lysosome_morphology0.74445546
121MP0003186_abnormal_redox_activity0.72051606
122MP0003937_abnormal_limbs/digits/tail_de0.70993570
123MP0003936_abnormal_reproductive_system0.70957059
124MP0001919_abnormal_reproductive_system0.70594278
125MP0003938_abnormal_ear_development0.68918275
126MP0009703_decreased_birth_body0.68605754
127MP0001929_abnormal_gametogenesis0.67944445
128MP0001697_abnormal_embryo_size0.65261743
129MP0001915_intracranial_hemorrhage0.64881185
130MP0008932_abnormal_embryonic_tissue0.64365216
131MP0003191_abnormal_cellular_cholesterol0.64342494
132MP0002736_abnormal_nociception_after0.63713796
133MP0003119_abnormal_digestive_system0.62835992
134MP0002210_abnormal_sex_determination0.62173538
135MP0005310_abnormal_salivary_gland0.61832189
136MP0001529_abnormal_vocalization0.61467750
137MP0005084_abnormal_gallbladder_morpholo0.60999589
138MP0005253_abnormal_eye_physiology0.60788276
139MP0000579_abnormal_nail_morphology0.60672902
140MP0003690_abnormal_glial_cell0.60469003
141MP0001666_abnormal_nutrient_absorption0.59949565
142MP0005380_embryogenesis_phenotype0.59872787
143MP0001672_abnormal_embryogenesis/_devel0.59872787
144MP0005395_other_phenotype0.57829200
145MP0000313_abnormal_cell_death0.57498817
146MP0002085_abnormal_embryonic_tissue0.57435292
147MP0000013_abnormal_adipose_tissue0.56957261
148MP0002653_abnormal_ependyma_morphology0.53599878
149MP0000350_abnormal_cell_proliferation0.53423939
150MP0000778_abnormal_nervous_system0.51710052
151MP0005275_abnormal_skin_tensile0.51489389
152MP0006036_abnormal_mitochondrial_physio0.49405479
153MP0009250_abnormal_appendicular_skeleto0.48605028
154MP0003943_abnormal_hepatobiliary_system0.46534290
155MP0002282_abnormal_trachea_morphology0.45552393
156MP0005076_abnormal_cell_differentiation0.43646293
157MP0000647_abnormal_sebaceous_gland0.43045855
158MP0003984_embryonic_growth_retardation0.42972769
159MP0002971_abnormal_brown_adipose0.42603512
160MP0002080_prenatal_lethality0.41372106
161MP0003861_abnormal_nervous_system0.41267418
162MP0002088_abnormal_embryonic_growth/wei0.40520825
163MP0000631_abnormal_neuroendocrine_gland0.40252501
164MP0002114_abnormal_axial_skeleton0.38319896
165MP0002233_abnormal_nose_morphology0.37529651
166MP0003890_abnormal_embryonic-extraembry0.35913380
167MP0003567_abnormal_fetal_cardiomyocyte0.35850709
168MP0002116_abnormal_craniofacial_bone0.35651800
169MP0001243_abnormal_dermal_layer0.35352732

Predicted human phenotypes

RankGene SetZ-score
1Gonadotropin excess (HP:0000837)7.01574054
2Spontaneous abortion (HP:0005268)6.67983824
3Oligodactyly (hands) (HP:0001180)5.91238135
4Volvulus (HP:0002580)5.88231019
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.43868017
6Degeneration of the lateral corticospinal tracts (HP:0002314)5.43868017
7Shoulder girdle muscle weakness (HP:0003547)5.07678910
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.74344473
9Prolonged partial thromboplastin time (HP:0003645)4.27561276
10Rimmed vacuoles (HP:0003805)4.17790165
11Abnormality of the corticospinal tract (HP:0002492)4.15505162
12Oligodactyly (HP:0012165)4.14615305
13Chromsome breakage (HP:0040012)3.97350258
14Increased nuchal translucency (HP:0010880)3.79102766
15Duplicated collecting system (HP:0000081)3.71400346
16Absent/shortened dynein arms (HP:0200106)3.58001165
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.58001165
18Impaired vibration sensation in the lower limbs (HP:0002166)3.48645372
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.42137479
20Parakeratosis (HP:0001036)3.41545860
21Amyotrophic lateral sclerosis (HP:0007354)3.40438235
22Facial hemangioma (HP:0000329)3.30953615
23Abnormality of the lower motor neuron (HP:0002366)3.29928187
24Horizontal nystagmus (HP:0000666)3.28357191
25Joint hemorrhage (HP:0005261)3.27673640
26Abnormality of the renal collecting system (HP:0004742)3.25033030
2711 pairs of ribs (HP:0000878)3.24352658
28Conjugated hyperbilirubinemia (HP:0002908)3.19397021
29Broad distal phalanx of finger (HP:0009836)3.14172371
30Decreased central vision (HP:0007663)3.10448280
31Intrahepatic cholestasis (HP:0001406)3.05693624
32Fair hair (HP:0002286)2.98556655
33Aplasia/Hypoplasia of the sternum (HP:0006714)2.93987929
34Upper motor neuron abnormality (HP:0002127)2.89506525
35Capillary hemangiomas (HP:0005306)2.88978439
36Duodenal stenosis (HP:0100867)2.77914362
37Small intestinal stenosis (HP:0012848)2.77914362
38Renal cortical cysts (HP:0000803)2.76756104
39Atrophy/Degeneration involving motor neurons (HP:0007373)2.72309279
40Abnormal lung lobation (HP:0002101)2.68994660
41Supernumerary spleens (HP:0009799)2.67460153
42Congenital sensorineural hearing impairment (HP:0008527)2.66613448
43Abnormality of methionine metabolism (HP:0010901)2.64646354
44Abnormality of pyrimidine metabolism (HP:0004353)2.62751558
45Abnormal respiratory motile cilium morphology (HP:0005938)2.62283178
46Abnormal respiratory epithelium morphology (HP:0012253)2.62283178
47Nephroblastoma (Wilms tumor) (HP:0002667)2.61898801
48Generalized hypopigmentation of hair (HP:0011358)2.60619855
49Abnormality of DNA repair (HP:0003254)2.58651392
50Embryonal renal neoplasm (HP:0011794)2.55674300
51Truncal obesity (HP:0001956)2.54202877
52Metaphyseal cupping (HP:0003021)2.53271108
53Abnormal ciliary motility (HP:0012262)2.53021593
54Abnormality of chromosome segregation (HP:0002916)2.52438751
55Osteomalacia (HP:0002749)2.48840661
56Urinary urgency (HP:0000012)2.44992192
57Septo-optic dysplasia (HP:0100842)2.42187203
58Hypophosphatemic rickets (HP:0004912)2.40111265
59Abnormality of cochlea (HP:0000375)2.39807404
60Large hands (HP:0001176)2.39196190
61Scotoma (HP:0000575)2.37925790
62Abnormal respiratory motile cilium physiology (HP:0012261)2.36446485
63Abnormality of secondary sexual hair (HP:0009888)2.35561108
64Abnormality of the axillary hair (HP:0100134)2.35561108
65Resting tremor (HP:0002322)2.35310598
66Non-midline cleft lip (HP:0100335)2.32718002
67Hand muscle atrophy (HP:0009130)2.31640627
68Thyroid-stimulating hormone excess (HP:0002925)2.30130932
69Hyperpituitarism (HP:0010514)2.28450757
70Tubulointerstitial abnormality (HP:0001969)2.27195818
71Abnormality of the renal cortex (HP:0011035)2.26307731
72Ectopic kidney (HP:0000086)2.25111694
73Abnormality of homocysteine metabolism (HP:0010919)2.24370116
74Homocystinuria (HP:0002156)2.24370116
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.20996623
76Azoospermia (HP:0000027)2.20733333
77Abnormality of the preputium (HP:0100587)2.20545961
78Wrist flexion contracture (HP:0001239)2.17965432
79Lip pit (HP:0100267)2.17379040
80Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16472256
81Spastic gait (HP:0002064)2.16298146
82Abnormality of the duodenum (HP:0002246)2.15911203
83Short nail (HP:0001799)2.13941337
84Prolonged neonatal jaundice (HP:0006579)2.12384605
85Proximal placement of thumb (HP:0009623)2.12035290
86Abnormality of the labia minora (HP:0012880)2.12034395
87White forelock (HP:0002211)2.10778426
88Alveolar cell carcinoma (HP:0006519)2.10751565
89Menstrual irregularities (HP:0000858)2.10502647
90Conical tooth (HP:0000698)2.09454135
91Limb-girdle muscle weakness (HP:0003325)2.08682801
92Hypothermia (HP:0002045)2.08101327
93Prostate neoplasm (HP:0100787)2.07879928
94Dry hair (HP:0011359)2.07669673
95Hypoplastic iliac wings (HP:0002866)2.07628198
96Impaired vibratory sensation (HP:0002495)2.06549017
97Patchy hypopigmentation of hair (HP:0011365)2.05756657
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03039535
99Abnormal protein N-linked glycosylation (HP:0012347)2.03039535
100Abnormal protein glycosylation (HP:0012346)2.03039535
101Abnormal glycosylation (HP:0012345)2.03039535
102Renal Fanconi syndrome (HP:0001994)2.01267873
103Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00991147
104Attenuation of retinal blood vessels (HP:0007843)1.98630560
105Progressive external ophthalmoplegia (HP:0000590)1.96803259
106Clubbing of toes (HP:0100760)1.95501801
1073-Methylglutaconic aciduria (HP:0003535)1.94914846
108Urinary bladder sphincter dysfunction (HP:0002839)1.94660757
109Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93598625
110Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.92946270
111Submucous cleft hard palate (HP:0000176)1.92259917
112Abnormality of renal resorption (HP:0011038)1.90786054
113Upper limb muscle weakness (HP:0003484)1.88600595
114Abnormality of chromosome stability (HP:0003220)1.86896908
115Abnormal delivery (HP:0001787)1.86361520
116Multicystic kidney dysplasia (HP:0000003)1.85998420
117Pili torti (HP:0003777)1.85129171
118Abnormality of the labia (HP:0000058)1.84076001
119Loss of speech (HP:0002371)1.83455724
120Neoplasm of the tracheobronchial system (HP:0100552)1.81657271
121Hypergonadotropic hypogonadism (HP:0000815)1.81501681
122Methylmalonic acidemia (HP:0002912)1.81327740
123Hypoplasia of the radius (HP:0002984)1.80816352
124Chronic hepatic failure (HP:0100626)1.80472302
125Stomatitis (HP:0010280)1.79896038
126Follicular hyperkeratosis (HP:0007502)1.79745071
127Abnormality of the renal medulla (HP:0100957)1.79678231
128Rhabdomyosarcoma (HP:0002859)1.79487511
129Meckel diverticulum (HP:0002245)1.78880264
130Infertility (HP:0000789)1.78836023
131Abnormal hair whorl (HP:0010721)1.78431906
132Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78069194
133Deviation of the thumb (HP:0009603)1.76975015
134Abnormality of the ileum (HP:0001549)1.76819535
135Stomach cancer (HP:0012126)1.76621111
136Abnormality of serum amino acid levels (HP:0003112)1.76228635
137Tubulointerstitial nephritis (HP:0001970)1.75938565
138Blepharitis (HP:0000498)1.75903283
139Duplication of thumb phalanx (HP:0009942)1.74219877
140Vascular calcification (HP:0004934)1.74161575
141Febrile seizures (HP:0002373)1.74101563
142Nephronophthisis (HP:0000090)1.73318866
143Vertebral arch anomaly (HP:0008438)1.73027064
144Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72753249
145Abnormality of the dental root (HP:0006486)1.71824655
146Taurodontia (HP:0000679)1.71824655
147Abnormality of permanent molar morphology (HP:0011071)1.71824655
148Abnormal spermatogenesis (HP:0008669)1.71435182
149Morphological abnormality of the inner ear (HP:0011390)1.71099360
150Pruritus (HP:0000989)1.70924992
151Abnormal biliary tract physiology (HP:0012439)1.70731764
152Bile duct proliferation (HP:0001408)1.70731764
153Hypochromic microcytic anemia (HP:0004840)1.70636735
154Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70185712
155Abnormality of alanine metabolism (HP:0010916)1.70185712
156Hyperalaninemia (HP:0003348)1.70185712
157Recurrent gram-negative bacterial infections (HP:0005420)1.69202554
158Male pseudohermaphroditism (HP:0000037)1.68962245
159Abnormality of incisor morphology (HP:0011063)1.68953055
160Anomalous pulmonary venous return (HP:0010772)1.68520389
161Panhypogammaglobulinemia (HP:0003139)1.67434759
162Increased IgM level (HP:0003496)1.67347985
163Widely spaced teeth (HP:0000687)1.67096166
164Recurrent sinusitis (HP:0011108)1.66898287
165Bell-shaped thorax (HP:0001591)1.65884285
166Clitoromegaly (HP:0000057)1.65214392
167Absent septum pellucidum (HP:0001331)1.65048870
168Long foot (HP:0001833)1.64762235
169Stage 5 chronic kidney disease (HP:0003774)1.64705872
170Lower limb muscle weakness (HP:0007340)1.64452830
171Upper limb amyotrophy (HP:0009129)1.64021177
172Distal upper limb amyotrophy (HP:0007149)1.64021177
173Renal tubular dysfunction (HP:0000124)1.63867764
174Median cleft lip (HP:0000161)1.63643067
175Optic nerve hypoplasia (HP:0000609)1.62622737
176Reduced antithrombin III activity (HP:0001976)1.61965969
177Medial flaring of the eyebrow (HP:0010747)1.61653904
178Hyperlipoproteinemia (HP:0010980)1.61640663
179Erythroderma (HP:0001019)1.61554664
180Recurrent pneumonia (HP:0006532)1.60656806
181Glomerulonephritis (HP:0000099)1.59601294
182Corneal erosion (HP:0200020)1.59170011
183Recurrent cutaneous fungal infections (HP:0011370)1.59134016

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK7.96267565
2CDK196.69063929
3CASK3.91374868
4IRAK33.71142490
5STK163.67085374
6MET3.12316494
7INSRR2.94733797
8BLK2.80185427
9ZAK2.60600400
10MAP3K142.57076947
11TNIK2.40481235
12CAMK1G2.38677682
13PBK2.21351749
14IRAK22.16615362
15EIF2AK22.12304014
16IRAK42.10866648
17TXK2.03338368
18STK381.93943438
19PRPF4B1.92695113
20MKNK21.86984117
21PTK2B1.86902555
22IRAK11.79999471
23GRK11.72740706
24BRAF1.69926004
25AKT31.69653308
26NEK61.68351022
27MAP3K131.65381087
28ADRBK21.62766325
29ACVR1B1.59490667
30BMPR1B1.58547217
31PLK11.51497413
32YES11.47100713
33PKN11.42841455
34SIK31.42813146
35BMX1.41755197
36GRK71.41725111
37NLK1.40166382
38STK38L1.32965789
39CSF1R1.30975406
40ARAF1.26103774
41BMPR21.22241501
42MKNK11.21066670
43PLK41.19529403
44IKBKB1.18513155
45NUAK11.17898900
46MAP3K91.15759398
47STK391.13044347
48IKBKE1.11959450
49MAP2K71.06216040
50WEE11.05813630
51CHEK11.01459207
52PRKCI0.96654492
53RET0.96110221
54CLK10.95668245
55KSR20.94438837
56KSR10.92385199
57CDK30.91509876
58PDGFRB0.91294021
59RPS6KB10.91059512
60PASK0.90861612
61MAP3K20.89894023
62TLK10.85439083
63MOS0.85208527
64PDK20.83787010
65SRPK10.83633992
66BCR0.83332921
67MAPK130.82084311
68PDK10.81876606
69BRSK10.81798225
70OXSR10.80585666
71AURKA0.79863373
72PDPK10.79821503
73ATM0.79177554
74TTK0.77862689
75WNK10.74269800
76PINK10.72548667
77CCNB10.72521643
78LATS10.72517024
79FES0.71438694
80MAPK150.71006463
81PIK3CG0.69308152
82SGK20.68546729
83MUSK0.68193733
84PRKCE0.67564372
85TEC0.66945297
86NEK20.66765424
87CHUK0.66545000
88TYRO30.66532542
89EGFR0.65643369
90MAP3K50.65083406
91STK110.64910739
92MARK30.63590424
93TNK20.63452457
94BRD40.62628514
95NTRK20.62399332
96STK40.59802631
97MAP3K40.59391537
98ERBB30.59292992
99MST1R0.58296262
100CDK60.57976774
101PRKCQ0.57890929
102LYN0.57674264
103RIPK40.56651477
104SGK4940.56290453
105SGK2230.56290453
106EPHA30.55744332
107MAP2K20.55643731
108CDK120.55542320
109MELK0.54655619
110TYK20.54133837
111MAPK70.52406417
112PTK20.51477975
113PDGFRA0.49357791
114WNK40.49109916
115NEK10.48465610
116EPHA20.46732254
117TAOK30.46099470
118BUB10.45803377
119CDK20.45211367
120JAK10.44991566
121RAF10.44881464
122ATR0.44005408
123NTRK30.43723166
124CDK40.42976787
125CDK11A0.42410362
126TRPM70.42298463
127VRK10.42206655
128CAMK2B0.41984168
129CSK0.41805141
130NEK90.40776224
131TIE10.38778379
132EPHA40.38562927
133CDK10.38341728
134BTK0.38246879
135LCK0.37816246
136CAMK10.35876600
137CSNK1E0.34401397
138DYRK30.33937916
139MAP2K60.33367763
140ABL20.33146876
141CAMK2A0.33144956
142PRKG10.32940102
143BCKDK0.30619939
144DYRK1A0.30283388
145PRKAA20.29246795
146PLK20.29132378
147ERBB20.28699351
148TAOK10.28644934
149FGFR30.28529457
150BRSK20.28425114
151CHEK20.27532706
152CDK70.27066930
153ERBB40.26982188
154DYRK20.26262695
155STK30.25869699
156SGK10.25513194
157PRKACA0.25175838
158FGR0.25096642
159IGF1R0.24926711
160FRK0.23844520
161ADRBK10.23759382
162RPS6KA50.23349558
163MARK10.23261905
164CDK90.22200803
165PRKDC0.20642749
166EIF2AK30.19009422
167RPS6KA10.18411272
168STK240.18056206
169PRKACB0.17214911
170CDK150.16112655
171CSNK2A20.15895207
172MAPK10.15693930
173CSNK2A10.15575148
174AKT20.14772505

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.30293827
2DNA replication_Homo sapiens_hsa030303.95479925
3Cell cycle_Homo sapiens_hsa041103.85134547
4Oocyte meiosis_Homo sapiens_hsa041143.70531535
5Nucleotide excision repair_Homo sapiens_hsa034203.18696551
6RNA transport_Homo sapiens_hsa030133.17607905
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049143.05168268
8Sulfur relay system_Homo sapiens_hsa041222.96637721
9Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.63352808
10Base excision repair_Homo sapiens_hsa034102.61059369
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.60055805
12Retinol metabolism_Homo sapiens_hsa008302.38588002
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.27629038
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.24781320
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.23432942
16Dorso-ventral axis formation_Homo sapiens_hsa043202.21187614
17Steroid biosynthesis_Homo sapiens_hsa001002.20920107
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.17061364
19Fatty acid elongation_Homo sapiens_hsa000622.16894142
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.16208936
21mRNA surveillance pathway_Homo sapiens_hsa030152.12150231
22Staphylococcus aureus infection_Homo sapiens_hsa051502.11273434
23Vitamin B6 metabolism_Homo sapiens_hsa007502.10288577
24Fanconi anemia pathway_Homo sapiens_hsa034602.07721058
25Histidine metabolism_Homo sapiens_hsa003401.95444890
26Complement and coagulation cascades_Homo sapiens_hsa046101.94059749
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92704987
28Tryptophan metabolism_Homo sapiens_hsa003801.92461774
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89301802
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89097499
31Vitamin digestion and absorption_Homo sapiens_hsa049771.86991340
32Peroxisome_Homo sapiens_hsa041461.75500809
33ABC transporters_Homo sapiens_hsa020101.72892119
34Chemical carcinogenesis_Homo sapiens_hsa052041.71707875
35Sphingolipid metabolism_Homo sapiens_hsa006001.70310512
36beta-Alanine metabolism_Homo sapiens_hsa004101.67807923
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62829238
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56403461
39Arachidonic acid metabolism_Homo sapiens_hsa005901.54800587
40Ether lipid metabolism_Homo sapiens_hsa005651.53690101
41RNA degradation_Homo sapiens_hsa030181.50575165
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47099986
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41615624
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41590132
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41283450
46Autoimmune thyroid disease_Homo sapiens_hsa053201.40671005
47Proteasome_Homo sapiens_hsa030501.40163843
48Linoleic acid metabolism_Homo sapiens_hsa005911.39551534
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34730775
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32908875
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28829922
52Allograft rejection_Homo sapiens_hsa053301.27891177
53mTOR signaling pathway_Homo sapiens_hsa041501.26464020
54Pyruvate metabolism_Homo sapiens_hsa006201.25045801
55Nicotine addiction_Homo sapiens_hsa050331.24887975
56Tyrosine metabolism_Homo sapiens_hsa003501.24386858
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23809904
58Circadian rhythm_Homo sapiens_hsa047101.23051096
59Phenylalanine metabolism_Homo sapiens_hsa003601.22558043
60Homologous recombination_Homo sapiens_hsa034401.22432023
61Graft-versus-host disease_Homo sapiens_hsa053321.21797690
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.21106134
63One carbon pool by folate_Homo sapiens_hsa006701.18064905
64Maturity onset diabetes of the young_Homo sapiens_hsa049501.15415582
65Phototransduction_Homo sapiens_hsa047441.13922343
66p53 signaling pathway_Homo sapiens_hsa041151.13354507
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11905085
68Non-homologous end-joining_Homo sapiens_hsa034501.11221471
69Protein export_Homo sapiens_hsa030601.10584317
70NF-kappa B signaling pathway_Homo sapiens_hsa040641.07430655
71Arginine and proline metabolism_Homo sapiens_hsa003301.06371616
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04743515
73SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01937546
74Primary immunodeficiency_Homo sapiens_hsa053400.95939465
75Sulfur metabolism_Homo sapiens_hsa009200.95225410
76RNA polymerase_Homo sapiens_hsa030200.93644153
77Basal transcription factors_Homo sapiens_hsa030220.91576162
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91227717
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90906906
80Propanoate metabolism_Homo sapiens_hsa006400.90534358
81Rheumatoid arthritis_Homo sapiens_hsa053230.88869177
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87904328
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86689326
84Regulation of autophagy_Homo sapiens_hsa041400.85968793
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.84277611
86Starch and sucrose metabolism_Homo sapiens_hsa005000.80594411
87Huntingtons disease_Homo sapiens_hsa050160.79619320
88N-Glycan biosynthesis_Homo sapiens_hsa005100.79361421
89Spliceosome_Homo sapiens_hsa030400.78280578
90Small cell lung cancer_Homo sapiens_hsa052220.76272011
91Butanoate metabolism_Homo sapiens_hsa006500.74966782
92Metabolic pathways_Homo sapiens_hsa011000.74089741
93PPAR signaling pathway_Homo sapiens_hsa033200.73531122
94Fatty acid degradation_Homo sapiens_hsa000710.73315494
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71209485
96Fatty acid metabolism_Homo sapiens_hsa012120.68020883
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67719023
98Inositol phosphate metabolism_Homo sapiens_hsa005620.67360525
99Selenocompound metabolism_Homo sapiens_hsa004500.63682030
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57972880
101Hematopoietic cell lineage_Homo sapiens_hsa046400.56998156
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56651478
103Asthma_Homo sapiens_hsa053100.56608178
104HTLV-I infection_Homo sapiens_hsa051660.56221341
105Fatty acid biosynthesis_Homo sapiens_hsa000610.55712266
106Taste transduction_Homo sapiens_hsa047420.55345915
107ErbB signaling pathway_Homo sapiens_hsa040120.54342222
108Choline metabolism in cancer_Homo sapiens_hsa052310.53619602
109Glutathione metabolism_Homo sapiens_hsa004800.53489395
110Pyrimidine metabolism_Homo sapiens_hsa002400.53442543
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51039922
112Glucagon signaling pathway_Homo sapiens_hsa049220.50195038
113Measles_Homo sapiens_hsa051620.48457915
114Folate biosynthesis_Homo sapiens_hsa007900.48105498
115Other glycan degradation_Homo sapiens_hsa005110.47244982
116Arginine biosynthesis_Homo sapiens_hsa002200.46018192
117Malaria_Homo sapiens_hsa051440.45735732
118African trypanosomiasis_Homo sapiens_hsa051430.45384625
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45003183
120Calcium signaling pathway_Homo sapiens_hsa040200.43551528
121Olfactory transduction_Homo sapiens_hsa047400.41786538
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41784481
123TGF-beta signaling pathway_Homo sapiens_hsa043500.41298594
124Oxidative phosphorylation_Homo sapiens_hsa001900.40831293
125Serotonergic synapse_Homo sapiens_hsa047260.40814572
126Lysine degradation_Homo sapiens_hsa003100.40497459
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.39446759
128Type II diabetes mellitus_Homo sapiens_hsa049300.38810760
129VEGF signaling pathway_Homo sapiens_hsa043700.38483696
130Purine metabolism_Homo sapiens_hsa002300.38280104
131Prostate cancer_Homo sapiens_hsa052150.38222714
132Ovarian steroidogenesis_Homo sapiens_hsa049130.37931138
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.37557396
134Axon guidance_Homo sapiens_hsa043600.36611099
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36599193
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.36217509
137Parkinsons disease_Homo sapiens_hsa050120.35953460
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33268584
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30814258
140Morphine addiction_Homo sapiens_hsa050320.28014761
141Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26504615
142Non-small cell lung cancer_Homo sapiens_hsa052230.24260556
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23482877
144MAPK signaling pathway_Homo sapiens_hsa040100.23371379
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22950791
146Viral carcinogenesis_Homo sapiens_hsa052030.22239721
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20844685
148Legionellosis_Homo sapiens_hsa051340.17003541
149Endometrial cancer_Homo sapiens_hsa052130.14579957
150Wnt signaling pathway_Homo sapiens_hsa043100.12408135
151Hedgehog signaling pathway_Homo sapiens_hsa043400.12343201
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11667094
153FoxO signaling pathway_Homo sapiens_hsa040680.11433180
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11392407
155Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.11083571
156Endocytosis_Homo sapiens_hsa041440.08355378
157Regulation of actin cytoskeleton_Homo sapiens_hsa048100.07712138
158Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.06357647
159Epstein-Barr virus infection_Homo sapiens_hsa051690.05778186
160Adherens junction_Homo sapiens_hsa045200.03876974
161Melanoma_Homo sapiens_hsa052180.03782011
162Protein digestion and absorption_Homo sapiens_hsa049740.03329246

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »