SPATA24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)9.96101559
2acrosome reaction (GO:0007340)9.70769392
3binding of sperm to zona pellucida (GO:0007339)9.41193790
4cell-cell recognition (GO:0009988)8.94151295
5axonemal dynein complex assembly (GO:0070286)8.82019450
6multicellular organism reproduction (GO:0032504)8.63850703
7cilium or flagellum-dependent cell motility (GO:0001539)8.29083068
8epithelial cilium movement (GO:0003351)8.27097251
9motile cilium assembly (GO:0044458)8.17874706
10spermatid development (GO:0007286)8.13530157
11plasma membrane fusion (GO:0045026)8.04569581
12regulation of cilium movement (GO:0003352)7.45943524
13reproduction (GO:0000003)7.32154302
14cilium movement (GO:0003341)7.16543051
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.52893675
16synaptonemal complex organization (GO:0070193)6.37129441
17male meiosis (GO:0007140)6.36008974
18piRNA metabolic process (GO:0034587)6.30218854
19synaptonemal complex assembly (GO:0007130)6.19887825
20single fertilization (GO:0007338)6.18098033
21negative regulation of inclusion body assembly (GO:0090084)5.93513777
22chaperone-mediated protein transport (GO:0072321)5.88368966
23microtubule depolymerization (GO:0007019)5.75982615
24* spermatogenesis (GO:0007283)5.62622149
25sperm capacitation (GO:0048240)5.61568818
26* male gamete generation (GO:0048232)5.61302732
27chromosome condensation (GO:0030261)5.34645200
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.32738517
29fertilization (GO:0009566)5.28580466
30establishment of protein localization to mitochondrial membrane (GO:0090151)5.18445502
31* gamete generation (GO:0007276)5.15264575
32organic cation transport (GO:0015695)5.11402026
33rRNA modification (GO:0000154)5.04942069
34DNA packaging (GO:0006323)5.03387943
35regulation of inclusion body assembly (GO:0090083)5.03263417
36maturation of SSU-rRNA (GO:0030490)4.97602975
37spermatid nucleus differentiation (GO:0007289)4.97189996
38regulation of mitochondrial translation (GO:0070129)4.75931372
39rRNA methylation (GO:0031167)4.74798194
40male meiosis I (GO:0007141)4.70446100
41energy coupled proton transport, down electrochemical gradient (GO:0015985)4.55240227
42ATP synthesis coupled proton transport (GO:0015986)4.55240227
43chromosome organization involved in meiosis (GO:0070192)4.54875408
44ventricular system development (GO:0021591)4.53532717
45germ cell development (GO:0007281)4.49328726
46ribosomal small subunit biogenesis (GO:0042274)4.46847641
47cellular process involved in reproduction in multicellular organism (GO:0022412)4.40913144
48GTP biosynthetic process (GO:0006183)4.35549705
49maturation of 5.8S rRNA (GO:0000460)4.31217125
50glycerol ether metabolic process (GO:0006662)4.27424728
51single strand break repair (GO:0000012)4.27037822
52DNA methylation involved in gamete generation (GO:0043046)4.26185755
53DNA replication checkpoint (GO:0000076)4.21497672
54regulation of microtubule-based movement (GO:0060632)4.20668224
55meiotic nuclear division (GO:0007126)4.19566896
56microtubule severing (GO:0051013)4.19135213
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.10933502
58DNA strand elongation involved in DNA replication (GO:0006271)4.08440505
59ribosomal small subunit assembly (GO:0000028)4.08006177
60chaperone-mediated protein complex assembly (GO:0051131)4.07408419
61meiosis I (GO:0007127)4.04463833
62cell recognition (GO:0008037)4.04414608
63seminiferous tubule development (GO:0072520)4.02262092
64* multicellular organismal reproductive process (GO:0048609)4.01497215
65calcium ion-dependent exocytosis (GO:0017156)3.99459828
66UTP biosynthetic process (GO:0006228)3.98053068
67inner mitochondrial membrane organization (GO:0007007)3.95793643
68DNA strand elongation (GO:0022616)3.94565845
69ether metabolic process (GO:0018904)3.93999775
70respiratory electron transport chain (GO:0022904)3.92810314
71electron transport chain (GO:0022900)3.89899002
72viral transcription (GO:0019083)3.88986997
73telomere maintenance via semi-conservative replication (GO:0032201)3.87187181
74translational termination (GO:0006415)3.83533216
75regulation of spindle checkpoint (GO:0090231)3.78505651
76ribonucleoprotein complex biogenesis (GO:0022613)3.70608708
77pseudouridine synthesis (GO:0001522)3.70518811
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.70410931
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.69578994
80nucleoside diphosphate phosphorylation (GO:0006165)3.68047919
81meiotic cell cycle (GO:0051321)3.65688738
82DNA deamination (GO:0045006)3.64368289
83cotranslational protein targeting to membrane (GO:0006613)3.63897430
84ribosomal large subunit biogenesis (GO:0042273)3.62494649
85protein targeting to ER (GO:0045047)3.61935442
86UTP metabolic process (GO:0046051)3.59441090
87protein targeting to mitochondrion (GO:0006626)3.57829911
88ribosome biogenesis (GO:0042254)3.57798470
89protein polyglutamylation (GO:0018095)3.53967145
90folic acid metabolic process (GO:0046655)3.53164289
91translational elongation (GO:0006414)3.52489017
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.52226662
93translation (GO:0006412)3.50611098
94establishment of protein localization to endoplasmic reticulum (GO:0072599)3.49876445
95proteasome assembly (GO:0043248)3.47417507
96base-excision repair, AP site formation (GO:0006285)3.46585899
97formation of translation preinitiation complex (GO:0001731)3.44433590
98rRNA processing (GO:0006364)3.44294142
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42978976
100oxidative phosphorylation (GO:0006119)3.42905666
101histone exchange (GO:0043486)3.40738417
102transcription elongation from RNA polymerase III promoter (GO:0006385)3.40461704
103termination of RNA polymerase III transcription (GO:0006386)3.40461704
104protein localization to endoplasmic reticulum (GO:0070972)3.39046989
105axoneme assembly (GO:0035082)3.38908541
106negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38282406
107negative regulation of ligase activity (GO:0051352)3.38282406
108guanosine-containing compound biosynthetic process (GO:1901070)3.34779782
109positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.31441135
110establishment of protein localization to mitochondrion (GO:0072655)3.31168799
111mitochondrial respiratory chain complex assembly (GO:0033108)3.31166834
112cellular component biogenesis (GO:0044085)3.30804423
113nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30189271
114sequestering of actin monomers (GO:0042989)3.27310217
115left/right pattern formation (GO:0060972)3.27071149
116protein localization to mitochondrion (GO:0070585)3.25954847
117telomere maintenance via recombination (GO:0000722)3.25951298
118CTP metabolic process (GO:0046036)3.25334841
119CTP biosynthetic process (GO:0006241)3.25334841
120L-serine metabolic process (GO:0006563)3.25179017
121intraciliary transport (GO:0042073)3.24189485
122rRNA metabolic process (GO:0016072)3.23944845
123protein localization to chromosome, centromeric region (GO:0071459)3.23702205
124translational initiation (GO:0006413)3.23600965
125microtubule polymerization or depolymerization (GO:0031109)3.23128962
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22216202
127mitotic sister chromatid cohesion (GO:0007064)3.21241678
128protein refolding (GO:0042026)3.20525452
129spliceosomal snRNP assembly (GO:0000387)3.19893041
130protein complex biogenesis (GO:0070271)3.19804441
131pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.18167685
132CENP-A containing nucleosome assembly (GO:0034080)3.17864685
133* multicellular organismal development (GO:0007275)3.17534118
134transcription-coupled nucleotide-excision repair (GO:0006283)3.10505658
135mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09730859
136mitochondrial respiratory chain complex I assembly (GO:0032981)3.09730859
137NADH dehydrogenase complex assembly (GO:0010257)3.09730859
138viral life cycle (GO:0019058)3.07369455
139pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.05365387
140pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.05184964
1417-methylguanosine mRNA capping (GO:0006370)3.04668245
142GDP-mannose metabolic process (GO:0019673)3.04629116
143monoubiquitinated protein deubiquitination (GO:0035520)3.04368310
144respiratory chain complex IV assembly (GO:0008535)3.02155723
145meiotic cell cycle process (GO:1903046)3.02138531
146pteridine-containing compound biosynthetic process (GO:0042559)3.02096216
147cellular protein complex disassembly (GO:0043624)3.01373385
148cellular ketone body metabolic process (GO:0046950)3.00801433
149response to pheromone (GO:0019236)2.97709242
150protein localization to cilium (GO:0061512)2.95444163
151DNA replication-dependent nucleosome assembly (GO:0006335)2.95409759
152DNA replication-dependent nucleosome organization (GO:0034723)2.95409759
153nucleus organization (GO:0006997)2.95390020
154purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.94693897
1557-methylguanosine RNA capping (GO:0009452)2.94646178
156RNA capping (GO:0036260)2.94646178
157positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93204320
158folic acid-containing compound biosynthetic process (GO:0009396)2.93183582
159protein deneddylation (GO:0000338)2.93164266
160peptidyl-histidine modification (GO:0018202)2.93005354
161centriole assembly (GO:0098534)2.91682902
162mitotic recombination (GO:0006312)2.91331910
163purine nucleoside triphosphate biosynthetic process (GO:0009145)2.91164036
164regulation of cellular amino acid metabolic process (GO:0006521)2.90340878
165DNA replication initiation (GO:0006270)2.89940663
166synapsis (GO:0007129)2.89494801
167ATP biosynthetic process (GO:0006754)2.89317329
168cytochrome complex assembly (GO:0017004)2.87502034
169DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87465416
170histone mRNA metabolic process (GO:0008334)2.87395017
171signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86595543
172signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86595543
173signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86595543
174pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.82030237
175centriole replication (GO:0007099)2.79951402
176cilium organization (GO:0044782)2.72630986
177positive regulation of macrophage activation (GO:0043032)2.71501036
178sexual reproduction (GO:0019953)2.71216898
179genitalia morphogenesis (GO:0035112)2.70860623
180regulation of centriole replication (GO:0046599)2.65174927
181protein K11-linked deubiquitination (GO:0035871)2.63722792
182chromatin remodeling at centromere (GO:0031055)2.62366720
183chromosome organization (GO:0051276)2.59192662
184protein complex localization (GO:0031503)2.58297925
185cilium morphogenesis (GO:0060271)2.58132886
186cilium assembly (GO:0042384)2.56793198
187sperm motility (GO:0030317)11.1627306
188fusion of sperm to egg plasma membrane (GO:0007342)10.7701191
189cell wall macromolecule metabolic process (GO:0044036)10.2795691
190cell wall macromolecule catabolic process (GO:0016998)10.2795691
191sperm-egg recognition (GO:0035036)10.0288194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.71120010
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.61272478
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93345122
4E2F7_22180533_ChIP-Seq_HELA_Human2.65000266
5THAP11_20581084_ChIP-Seq_MESCs_Mouse2.49742269
6CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.47757654
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45426813
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37547728
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32911872
10E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15011536
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11635548
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.09232023
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.08494916
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05591798
15ELK1_19687146_ChIP-ChIP_HELA_Human1.99659199
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94855583
17EZH2_22144423_ChIP-Seq_EOC_Human1.94147059
18POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93980164
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91366095
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.90189879
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82398312
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81150981
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80818097
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77200311
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77062486
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74315588
27ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73225642
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71199191
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70232354
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.70103051
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69190969
32VDR_22108803_ChIP-Seq_LS180_Human1.68480983
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62700780
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61689458
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60609765
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60558471
37MYC_18940864_ChIP-ChIP_HL60_Human1.60081212
38SOX2_22085726_ChIP-Seq_NPCs_Mouse1.57761032
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.56670669
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.56379329
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56366377
42KDM5A_27292631_Chip-Seq_BREAST_Human1.56209344
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53821021
44GATA3_21867929_ChIP-Seq_CD8_Mouse1.51855916
45BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50826791
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49768099
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49011255
48ZNF274_21170338_ChIP-Seq_K562_Hela1.48361741
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.48195117
50* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.47102547
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46994668
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44202060
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39655152
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38758159
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37967037
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35453028
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35256769
58* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34328023
59STAT1_17558387_ChIP-Seq_HELA_Human1.32645354
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.31727722
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.31531276
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31032991
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.30501791
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29205448
65FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28323702
66* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27749646
67ZNF263_19887448_ChIP-Seq_K562_Human1.25013942
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24248983
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24144413
70KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23772655
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22776029
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22629029
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22096622
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21783507
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20878964
76ERG_20517297_ChIP-Seq_VCAP_Human1.19475439
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17704288
78* VDR_23849224_ChIP-Seq_CD4+_Human1.15593585
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.15010940
80AR_21909140_ChIP-Seq_LNCAP_Human1.14180302
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14160911
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12943536
83SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12021905
84* P53_21459846_ChIP-Seq_SAOS-2_Human1.11936324
85WDR5_24793694_ChIP-Seq_LNCAP_Human1.11040984
86TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10028189
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08997768
88CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08893839
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08542308
90GATA3_21867929_ChIP-Seq_TH1_Mouse1.08362456
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07343504
92ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06662148
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06337930
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05655054
95XRN2_22483619_ChIP-Seq_HELA_Human1.05375246
96* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04366543
97GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.03827088
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03540381
99FOXP1_21924763_ChIP-Seq_HESCs_Human1.03520079
100MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03279093
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03144960
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02982097
103* FOXP3_21729870_ChIP-Seq_TREG_Human1.02609630
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.02414877
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01954401
106GABP_19822575_ChIP-Seq_HepG2_Human1.01437926
107CTCF_26484167_Chip-Seq_Bcells_Mouse1.01073118
108CIITA_25753668_ChIP-Seq_RAJI_Human1.00671388
109RARA_24833708_ChIP-Seq_LIVER_Mouse1.00091919
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99959205
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99519302
112LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.98830702
113DCP1A_22483619_ChIP-Seq_HELA_Human0.98760417
114ELK1_22589737_ChIP-Seq_MCF10A_Human0.98405280
115* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98113416
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97925271
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97426536
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95926164
119SPI1_26923725_Chip-Seq_HPCs_Mouse0.95825954
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95650784
121CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95262631
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94911225
123YY1_21170310_ChIP-Seq_MESCs_Mouse0.94135192
124NANOG_20526341_ChIP-Seq_ESCs_Human0.93930920
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93544456
126* TAL1_26923725_Chip-Seq_HPCs_Mouse0.93510741
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93481094
128TTF2_22483619_ChIP-Seq_HELA_Human0.92796524
129CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92402143
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91872822
131SRF_21415370_ChIP-Seq_HL-1_Mouse0.91785699
132HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91002582
133HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90500155
134CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90450810
135KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89680779
136* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89221809
137FLI1_21867929_ChIP-Seq_CD8_Mouse0.88317161
138SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87881569
139BCOR_27268052_Chip-Seq_Bcells_Human0.87629457
140* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87314589
141PHF8_20622854_ChIP-Seq_HELA_Human0.86884234
142EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86754547
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85828964
144KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80948521
145TFEB_21752829_ChIP-Seq_HELA_Human0.80717611
146CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80412053
147EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78561395
148SOX17_20123909_ChIP-Seq_XEN_Mouse0.77974562
149ELF5_23300383_ChIP-Seq_T47D_Human0.76300233
150SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74452136
151KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74380396
152SOX2_16153702_ChIP-ChIP_HESCs_Human0.73919082
153CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73865810
154GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73423984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.41904546
2MP0001929_abnormal_gametogenesis5.27570571
3MP0008877_abnormal_DNA_methylation4.46229149
4MP0002210_abnormal_sex_determination3.49491229
5MP0001145_abnormal_male_reproductive2.99899154
6MP0002161_abnormal_fertility/fecundity2.98592098
7MP0000653_abnormal_sex_gland2.60445762
8MP0008058_abnormal_DNA_repair2.54684587
9MP0005451_abnormal_body_composition2.49450131
10MP0010094_abnormal_chromosome_stability2.44465862
11MP0002653_abnormal_ependyma_morphology2.20042685
12MP0003718_maternal_effect2.11542672
13MP0008057_abnormal_DNA_replication2.04829433
14MP0005410_abnormal_fertilization14.2292007
15MP0002160_abnormal_reproductive_system1.92372553
16MP0003111_abnormal_nucleus_morphology1.89637185
17MP0003890_abnormal_embryonic-extraembry1.85619105
18MP0005408_hypopigmentation1.84490157
19MP0003693_abnormal_embryo_hatching1.79649514
20MP0008007_abnormal_cellular_replicative1.71759168
21MP0005670_abnormal_white_adipose1.70747357
22MP0004145_abnormal_muscle_electrophysio1.68033647
23MP0003567_abnormal_fetal_cardiomyocyte1.66355933
24MP0004957_abnormal_blastocyst_morpholog1.66244599
25MP0003077_abnormal_cell_cycle1.64171298
26MP0005084_abnormal_gallbladder_morpholo1.63758071
27MP0003941_abnormal_skin_development1.44045730
28MP0005645_abnormal_hypothalamus_physiol1.41852700
29MP0003786_premature_aging1.32419864
30MP0001661_extended_life_span1.24834148
31MP0003646_muscle_fatigue1.23154411
32MP0008875_abnormal_xenobiotic_pharmacok1.18525484
33MP0004233_abnormal_muscle_weight1.18368913
34MP0005389_reproductive_system_phenotype1.18337911
35MP0005332_abnormal_amino_acid1.15895574
36MP0006036_abnormal_mitochondrial_physio1.15224074
37MP0002282_abnormal_trachea_morphology1.13175762
38MP0008789_abnormal_olfactory_epithelium1.10708245
39MP0008932_abnormal_embryonic_tissue1.10650537
40MP0001545_abnormal_hematopoietic_system1.09772476
41MP0005397_hematopoietic_system_phenotyp1.09772476
42MP0005623_abnormal_meninges_morphology1.07467884
43MP0002254_reproductive_system_inflammat1.04924185
44MP0002234_abnormal_pharynx_morphology1.03991035
45MP0005395_other_phenotype1.03373081
46MP0001293_anophthalmia1.01755689
47MP0006292_abnormal_olfactory_placode1.01082798
48MP0005379_endocrine/exocrine_gland_phen1.00432268
49MP0002139_abnormal_hepatobiliary_system0.98410583
50MP0001730_embryonic_growth_arrest0.97015526
51MP0003315_abnormal_perineum_morphology0.94003475
52MP0003806_abnormal_nucleotide_metabolis0.93796552
53MP0002132_abnormal_respiratory_system0.92150379
54MP0000372_irregular_coat_pigmentation0.92036887
55MP0004133_heterotaxia0.91380578
56MP0004808_abnormal_hematopoietic_stem0.90434018
57MP0008995_early_reproductive_senescence0.89744416
58MP0002163_abnormal_gland_morphology0.88299600
59MP0009672_abnormal_birth_weight0.87649846
60MP0001984_abnormal_olfaction0.85262042
61MP0004147_increased_porphyrin_level0.85017466
62MP0005085_abnormal_gallbladder_physiolo0.83184473
63MP0003137_abnormal_impulse_conducting0.81165072
64MP0000313_abnormal_cell_death0.81165020
65MP0003011_delayed_dark_adaptation0.79203720
66MP0005220_abnormal_exocrine_pancreas0.78939972
67MP0000566_synostosis0.77871756
68MP0003937_abnormal_limbs/digits/tail_de0.77140475
69MP0005330_cardiomyopathy0.76251060
70MP0001764_abnormal_homeostasis0.73872200
71MP0000678_abnormal_parathyroid_gland0.71333620
72MP0001765_abnormal_ion_homeostasis0.71300874
73MP0000747_muscle_weakness0.71290045
74MP0000751_myopathy0.70414836
75MP0001666_abnormal_nutrient_absorption0.70101171
76MP0005636_abnormal_mineral_homeostasis0.69585781
77MP0002697_abnormal_eye_size0.68078763
78MP0005499_abnormal_olfactory_system0.66587122
79MP0005394_taste/olfaction_phenotype0.66587122
80MP0002751_abnormal_autonomic_nervous0.65990238
81MP0006072_abnormal_retinal_apoptosis0.65734037
82MP0001944_abnormal_pancreas_morphology0.65277105
83MP0000358_abnormal_cell_content/0.64971146
84MP0001697_abnormal_embryo_size0.63778465
85MP0005075_abnormal_melanosome_morpholog0.62799394
86MP0001346_abnormal_lacrimal_gland0.62061806
87MP0004019_abnormal_vitamin_homeostasis0.61870568
88MP0006054_spinal_hemorrhage0.61322191
89MP0000350_abnormal_cell_proliferation0.61024301
90MP0002127_abnormal_cardiovascular_syste0.60915196
91MP0005319_abnormal_enzyme/_coenzyme0.59580456
92MP0003942_abnormal_urinary_system0.59376605
93MP0001881_abnormal_mammary_gland0.59093108
94MP0003115_abnormal_respiratory_system0.58868515
95MP0002080_prenatal_lethality0.56785625
96MP0002396_abnormal_hematopoietic_system0.56111344
97MP0001119_abnormal_female_reproductive0.54507534
98MP0002019_abnormal_tumor_incidence0.54483230
99MP0003656_abnormal_erythrocyte_physiolo0.53883744
100MP0010307_abnormal_tumor_latency0.53239410
101MP0005647_abnormal_sex_gland0.52882618
102MP0003699_abnormal_female_reproductive0.50535841
103MP0001672_abnormal_embryogenesis/_devel0.49649560
104MP0005380_embryogenesis_phenotype0.49649560
105MP0003186_abnormal_redox_activity0.49066160
106MP0004134_abnormal_chest_morphology0.48423542
107MP0000749_muscle_degeneration0.46343759
108MP0009697_abnormal_copulation0.46246940
109MP0002085_abnormal_embryonic_tissue0.45874608
110MP0009379_abnormal_foot_pigmentation0.45775255
111MP0005391_vision/eye_phenotype0.45286861
112MP0003984_embryonic_growth_retardation0.45062773
113MP0006035_abnormal_mitochondrial_morpho0.45001829
114MP0003136_yellow_coat_color0.44222541
115MP0002269_muscular_atrophy0.42917601
116MP0002398_abnormal_bone_marrow0.42447190
117MP0000703_abnormal_thymus_morphology0.42306802
118MP0002084_abnormal_developmental_patter0.41697308
119MP0002092_abnormal_eye_morphology0.40981745
120MP0002088_abnormal_embryonic_growth/wei0.40454573
121MP0001727_abnormal_embryo_implantation0.40031919
122MP0009278_abnormal_bone_marrow0.39708171
123MP0003878_abnormal_ear_physiology0.39657025
124MP0005377_hearing/vestibular/ear_phenot0.39657025
125MP0002405_respiratory_system_inflammati0.39282316
126MP0001919_abnormal_reproductive_system0.38759302
127MP0000490_abnormal_crypts_of0.38465062
128MP0003943_abnormal_hepatobiliary_system0.36863398
129MP0002928_abnormal_bile_duct0.36216820
130MP0005174_abnormal_tail_pigmentation0.36086450
131MP0001529_abnormal_vocalization0.35797173
132MP0005253_abnormal_eye_physiology0.35756603
133MP0000689_abnormal_spleen_morphology0.35068453
134MP0003123_paternal_imprinting0.34733593
135MP0003763_abnormal_thymus_physiology0.34045498
136MP0000015_abnormal_ear_pigmentation0.33493405
137MP0002095_abnormal_skin_pigmentation0.33339291
138MP0001324_abnormal_eye_pigmentation0.32271187
139MP0003950_abnormal_plasma_membrane0.32131965
140MP0005266_abnormal_metabolism0.31957632
141MP0002938_white_spotting0.31303099
142MP0002102_abnormal_ear_morphology0.30671376
143MP0000049_abnormal_middle_ear0.30072968

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.14718685
2Abnormal respiratory epithelium morphology (HP:0012253)8.86488776
3Abnormal respiratory motile cilium morphology (HP:0005938)8.86488776
4Abnormal ciliary motility (HP:0012262)7.55468770
5Rhinitis (HP:0012384)7.53224003
6Chronic bronchitis (HP:0004469)6.96340121
7Nasal polyposis (HP:0100582)6.11071770
8Infertility (HP:0000789)5.92320665
9Abnormality of the nasal mucosa (HP:0000433)5.02512193
10Bronchiectasis (HP:0002110)4.55187405
11Bronchitis (HP:0012387)4.49276305
12Abnormal mitochondria in muscle tissue (HP:0008316)4.34062258
13Nephronophthisis (HP:0000090)4.29264599
14Acute encephalopathy (HP:0006846)4.27936737
15Mitochondrial inheritance (HP:0001427)4.08885241
16Type I transferrin isoform profile (HP:0003642)4.06888694
17Increased hepatocellular lipid droplets (HP:0006565)3.94487132
18Reduced antithrombin III activity (HP:0001976)3.86621043
19Progressive macrocephaly (HP:0004481)3.75355791
20Male infertility (HP:0003251)3.70186530
21Increased CSF lactate (HP:0002490)3.66446809
22Abnormal spermatogenesis (HP:0008669)3.64586773
23Recurrent sinusitis (HP:0011108)3.49774672
24Cerebral edema (HP:0002181)3.48043899
25Lipid accumulation in hepatocytes (HP:0006561)3.42116702
26Increased intramyocellular lipid droplets (HP:0012240)3.38351577
27Renal Fanconi syndrome (HP:0001994)3.28797716
28Hepatocellular necrosis (HP:0001404)3.26202384
29Reticulocytopenia (HP:0001896)3.19685258
30Exercise intolerance (HP:0003546)3.18185114
31Abnormality of the renal medulla (HP:0100957)3.15615907
32Recurrent otitis media (HP:0000403)3.13456074
33Exertional dyspnea (HP:0002875)3.11981050
34Molar tooth sign on MRI (HP:0002419)3.04449088
35Abnormality of midbrain morphology (HP:0002418)3.04449088
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.99193201
37Abnormal protein N-linked glycosylation (HP:0012347)2.99193201
38Abnormal protein glycosylation (HP:0012346)2.99193201
39Abnormal glycosylation (HP:0012345)2.99193201
40Hepatic necrosis (HP:0002605)2.95133063
41Chronic hepatic failure (HP:0100626)2.92119675
42Macrocytic anemia (HP:0001972)2.90676083
43Recurrent bronchitis (HP:0002837)2.84567094
44Lactic acidosis (HP:0003128)2.84334096
45Tubulointerstitial nephritis (HP:0001970)2.84167547
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76189160
47Medial flaring of the eyebrow (HP:0010747)2.75536571
48Increased muscle lipid content (HP:0009058)2.72648335
49Absent thumb (HP:0009777)2.70227905
50Increased serum lactate (HP:0002151)2.69826314
51Chromsome breakage (HP:0040012)2.66315446
52Poor head control (HP:0002421)2.64422603
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.63982412
54Abnormality of the ileum (HP:0001549)2.60266655
55Abnormality of DNA repair (HP:0003254)2.59013282
56Meckel diverticulum (HP:0002245)2.58119197
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.57046695
58Abnormal number of erythroid precursors (HP:0012131)2.56076969
59Abnormality of glycolysis (HP:0004366)2.53534276
60Abnormality of cells of the erythroid lineage (HP:0012130)2.51025126
61Respiratory failure (HP:0002878)2.50859936
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50854755
63Hyperglycinuria (HP:0003108)2.46771869
64Pancreatic fibrosis (HP:0100732)2.41402696
65Gonadotropin excess (HP:0000837)2.39277335
66Abnormality of the preputium (HP:0100587)2.36220335
67Methylmalonic acidemia (HP:0002912)2.36076477
68Increased serum pyruvate (HP:0003542)2.34360720
69Impulsivity (HP:0100710)2.34130267
70Tubular atrophy (HP:0000092)2.31942282
71Carpal bone hypoplasia (HP:0001498)2.31465559
72Hypoplasia of the pons (HP:0012110)2.30851831
73Megaloblastic anemia (HP:0001889)2.29029763
74Postaxial foot polydactyly (HP:0001830)2.27841078
75Tubulointerstitial abnormality (HP:0001969)2.26198213
76True hermaphroditism (HP:0010459)2.25702809
77Supernumerary spleens (HP:0009799)2.24411224
78Abnormality of urine glucose concentration (HP:0011016)2.20233587
79Glycosuria (HP:0003076)2.20233587
80Azoospermia (HP:0000027)2.18257601
81Testicular atrophy (HP:0000029)2.16254519
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15733332
83Colon cancer (HP:0003003)2.14474457
84Abnormality of the pons (HP:0007361)2.14438956
85Methylmalonic aciduria (HP:0012120)2.08344868
86Chronic sinusitis (HP:0011109)2.06460129
87Optic disc pallor (HP:0000543)2.04851132
88Cholecystitis (HP:0001082)2.04814771
89Abnormal gallbladder physiology (HP:0012438)2.04814771
90Microvesicular hepatic steatosis (HP:0001414)2.02667736
91Facial cleft (HP:0002006)2.01214834
92Acute hepatic failure (HP:0006554)2.00751549
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.2706168
94Dynein arm defect of respiratory motile cilia (HP:0012255)11.5376625
95Absent/shortened dynein arms (HP:0200106)11.5376625
96Abnormality of endocrine pancreas physiology (HP:0012093)1.98857762
97Abnormality of the pancreatic islet cells (HP:0006476)1.98857762
98Aplastic anemia (HP:0001915)1.98748211
99Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97419185
100Abnormality of chromosome stability (HP:0003220)1.96849564
101Respiratory difficulties (HP:0002880)1.96702320
102Myopathic facies (HP:0002058)1.96552948
103Overlapping toe (HP:0001845)1.96429774
104Pallor (HP:0000980)1.94681765
105Leukodystrophy (HP:0002415)1.93077121
106Abnormality of glycine metabolism (HP:0010895)1.92633651
107Abnormality of serine family amino acid metabolism (HP:0010894)1.92633651
108Congenital hepatic fibrosis (HP:0002612)1.89353073
109Abnormality of methionine metabolism (HP:0010901)1.87783749
110Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86553001
111Lethargy (HP:0001254)1.86309270
112Progressive muscle weakness (HP:0003323)1.86296815
1133-Methylglutaconic aciduria (HP:0003535)1.86240515
114Squamous cell carcinoma (HP:0002860)1.86126953
115Exercise-induced muscle cramps (HP:0003710)1.84815359
116Pancytopenia (HP:0001876)1.84518789
117Multiple enchondromatosis (HP:0005701)1.84155164
118Deformed tarsal bones (HP:0008119)1.82691071
119Fibular hypoplasia (HP:0003038)1.82472431
120Hyperglycinemia (HP:0002154)1.81872038
121Horseshoe kidney (HP:0000085)1.80108699
122Pancreatic cysts (HP:0001737)1.79709779
123Abnormality of renal resorption (HP:0011038)1.79605771
124Small intestinal stenosis (HP:0012848)1.78504015
125Duodenal stenosis (HP:0100867)1.78504015
126Abnormal biliary tract physiology (HP:0012439)1.76141621
127Bile duct proliferation (HP:0001408)1.76141621
128Congenital primary aphakia (HP:0007707)1.72927517
129Cystic liver disease (HP:0006706)1.72130682
130Median cleft lip (HP:0000161)1.71939452
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.70839563
132Stage 5 chronic kidney disease (HP:0003774)1.70589982
13311 pairs of ribs (HP:0000878)1.70365705
134Oculomotor apraxia (HP:0000657)1.70182543
135Tubulointerstitial fibrosis (HP:0005576)1.68220320
136Polydipsia (HP:0001959)1.66842962
137Abnormal drinking behavior (HP:0030082)1.66842962
138Postaxial hand polydactyly (HP:0001162)1.63356494
139Abnormality of the renal cortex (HP:0011035)1.61954103
140Gait imbalance (HP:0002141)1.61862909
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59862633
142Absent epiphyses (HP:0010577)1.59862633
143Short ribs (HP:0000773)1.58939467
144Type 2 muscle fiber atrophy (HP:0003554)1.58343316
145Abnormality of dentin (HP:0010299)1.58018943
146Decreased central vision (HP:0007663)1.50178913
147Anencephaly (HP:0002323)1.50075751
148Aplasia/Hypoplasia of the lens (HP:0008063)1.49458336
149Sloping forehead (HP:0000340)1.49285879
150Cerebellar dysplasia (HP:0007033)1.49223115
151Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.48553407
152Decreased activity of mitochondrial respiratory chain (HP:0008972)1.48553407
153Abnormality of permanent molar morphology (HP:0011071)1.48033512
154Abnormality of the dental root (HP:0006486)1.48033512
155Taurodontia (HP:0000679)1.48033512
156Renal dysplasia (HP:0000110)1.46652632
157Nephrogenic diabetes insipidus (HP:0009806)1.45737969
158Muscle fiber atrophy (HP:0100295)1.45608991
159Dyschromatopsia (HP:0007641)1.43507824
160Acute necrotizing encephalopathy (HP:0006965)1.40026924
161Occipital encephalocele (HP:0002085)1.39843540
162Sclerocornea (HP:0000647)1.39533685
163Abnormality of renal excretion (HP:0011036)1.37149859
164Congenital malformation of the right heart (HP:0011723)1.36995420
165Double outlet right ventricle (HP:0001719)1.36995420
166Abnormal lung lobation (HP:0002101)1.36309883
167Broad distal phalanx of finger (HP:0009836)1.36095432
168Genital tract atresia (HP:0001827)1.35902384
169Cleft eyelid (HP:0000625)1.34155247
170Abnormality of molar morphology (HP:0011070)1.33474732
171Abnormality of molar (HP:0011077)1.33474732
172Degeneration of anterior horn cells (HP:0002398)1.33344090
173Abnormality of the anterior horn cell (HP:0006802)1.33344090
174Rhabdomyolysis (HP:0003201)1.32827350
175Transposition of the great arteries (HP:0001669)1.31880129
176Abnormal connection of the cardiac segments (HP:0011545)1.31880129
177Abnormal ventriculo-arterial connection (HP:0011563)1.31880129
178Vaginal atresia (HP:0000148)1.31797311
179Abnormality of the dental pulp (HP:0006479)1.30999015
180Microglossia (HP:0000171)1.27557352
181Selective tooth agenesis (HP:0001592)1.26067810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.28284778
2PDK37.28284778
3TESK15.70563822
4PDK24.64301668
5VRK23.69458300
6PRKD33.43482845
7ICK3.42353609
8MAP4K23.29773984
9BCKDK2.89749039
10NEK22.31560722
11WEE12.19863507
12STK392.12142613
13PTK2B2.09424415
14WNK42.06345291
15INSRR2.03659308
16BUB11.99286775
17NEK11.88905075
18CCNB11.85751804
19TSSK61.81669019
20DYRK31.78781970
21CDC71.74509783
22PNCK1.72379755
23CAMK1D1.64882717
24PLK21.48893566
25PASK1.45716214
26DYRK1B1.42158020
27TAF11.38997681
28TESK21.34255441
29MAPK151.31889895
30BRSK21.31125338
31TTK1.30779711
32STK161.23255684
33CAMK1G1.17154604
34CDK81.17076085
35VRK11.12513546
36PLK40.98350464
37CHEK20.97591084
38SMG10.93321368
39EIF2AK10.92773338
40BRSK10.86388692
41MAPKAPK50.85938209
42ATR0.85443185
43PLK10.83610412
44STK380.82276492
45PDK10.82181649
46NME20.80787300
47EEF2K0.80296711
48AURKA0.75075123
49TLK10.74954974
50PRKCI0.74606738
51CHEK10.68485258
52PIM20.67094816
53STK30.64180867
54PAK10.63691712
55STK100.62477635
56MUSK0.62431768
57AURKB0.61586495
58AKT20.61029320
59SRPK10.59587092
60CDK120.58597408
61DYRK20.56554118
62IRAK10.56448061
63TRIM280.55362618
64RPS6KA40.50293303
65ATM0.48028205
66CDK30.47695318
67MST1R0.47544665
68PAK40.47493720
69WNK10.46829146
70BRAF0.45494497
71NEK90.44560348
72CLK10.44360601
73EIF2AK30.43964927
74CSNK2A10.43518557
75PINK10.43121260
76MST40.42401214
77LRRK20.41761239
78PRKDC0.41142421
79DAPK30.40835038
80OXSR10.40423332
81DAPK10.40231335
82NUAK10.40196312
83MAP3K100.39570412
84MKNK10.38474201
85MAP4K10.37761942
86CDK40.37337744
87CDK70.36143779
88CDK190.35588438
89PIM10.34922926
90PBK0.34781190
91PDPK10.34749529
92PLK30.34461958
93CSNK2A20.34431387
94CSNK1E0.32331450
95BMPR1B0.31939320
96CSNK1A10.31865005
97PAK20.31660789
98KDR0.31228673
99STK40.29073465
100RPS6KA50.28985413
101MAP2K60.28478918
102MAPK110.28462566
103MAPKAPK30.28252882
104BTK0.25962550
105FRK0.25537799
106CSF1R0.25364995
107PIK3CG0.25125209
108MAP3K80.23642408
109AKT10.22681565
110EIF2AK20.21648304
111CDK20.19731146
112LIMK10.19334331
113ZAK0.19259786
114CDK10.18587923
115CDK150.17919274
116TIE10.17722266
117CDK11A0.17435327
118CDK180.15465622
119PRKG20.14794314
120OBSCN0.13562118
121MARK30.12919552
122YES10.12654070
123RPS6KB20.12614159
124ARAF0.12436384
125PRKCG0.11911769
126NME10.11678044
127TEC0.11483733
128STK38L0.11298918
129RIPK40.11039237
130GRK60.11027917
131MKNK20.11001621
132MYLK0.10976976
133CDK140.10558284
134RPS6KA10.09241435
135TGFBR10.08727126
136RPS6KB10.08213123
137ILK0.07088340
138ACVR1B0.06899028

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.97540507
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.10240375
3Basal transcription factors_Homo sapiens_hsa030223.08911174
4Vitamin B6 metabolism_Homo sapiens_hsa007502.97521897
5Mismatch repair_Homo sapiens_hsa034302.88528840
6Ribosome_Homo sapiens_hsa030102.67190598
7Proteasome_Homo sapiens_hsa030502.62954742
8Pyruvate metabolism_Homo sapiens_hsa006202.62333609
9Fanconi anemia pathway_Homo sapiens_hsa034602.54412093
10Base excision repair_Homo sapiens_hsa034102.48337808
11Homologous recombination_Homo sapiens_hsa034402.38843921
12Fatty acid biosynthesis_Homo sapiens_hsa000612.30560663
13Pyrimidine metabolism_Homo sapiens_hsa002402.28385039
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28348250
15Nucleotide excision repair_Homo sapiens_hsa034202.20171091
16Huntingtons disease_Homo sapiens_hsa050162.18449204
17Spliceosome_Homo sapiens_hsa030402.13818709
18RNA transport_Homo sapiens_hsa030132.11993289
19Linoleic acid metabolism_Homo sapiens_hsa005911.99248248
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.97080671
21Propanoate metabolism_Homo sapiens_hsa006401.96707627
22Pentose phosphate pathway_Homo sapiens_hsa000301.89415861
23Purine metabolism_Homo sapiens_hsa002301.82204727
24Non-homologous end-joining_Homo sapiens_hsa034501.73976555
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68468066
26Cell cycle_Homo sapiens_hsa041101.66199513
27Selenocompound metabolism_Homo sapiens_hsa004501.65269117
28Parkinsons disease_Homo sapiens_hsa050121.58494542
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58014202
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56359657
31RNA polymerase_Homo sapiens_hsa030201.56252852
32Oxidative phosphorylation_Homo sapiens_hsa001901.54480774
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.53224574
34Protein export_Homo sapiens_hsa030601.47325519
35Oocyte meiosis_Homo sapiens_hsa041141.39196241
36Glucagon signaling pathway_Homo sapiens_hsa049221.37969949
37mRNA surveillance pathway_Homo sapiens_hsa030151.36699040
38Glutathione metabolism_Homo sapiens_hsa004801.35776347
39RNA degradation_Homo sapiens_hsa030181.34171659
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31834293
41Carbon metabolism_Homo sapiens_hsa012001.29081708
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27892272
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26555090
44Cardiac muscle contraction_Homo sapiens_hsa042601.26136553
45Folate biosynthesis_Homo sapiens_hsa007901.25711175
46Antigen processing and presentation_Homo sapiens_hsa046121.15494569
47Systemic lupus erythematosus_Homo sapiens_hsa053221.15435848
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07309716
49Alzheimers disease_Homo sapiens_hsa050101.00786878
50Steroid biosynthesis_Homo sapiens_hsa001001.00737081
51Biosynthesis of amino acids_Homo sapiens_hsa012300.98120111
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97482675
53Fructose and mannose metabolism_Homo sapiens_hsa000510.93471658
54Butanoate metabolism_Homo sapiens_hsa006500.93042178
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.87923707
56Arachidonic acid metabolism_Homo sapiens_hsa005900.86245779
57Ether lipid metabolism_Homo sapiens_hsa005650.85139889
58Arginine and proline metabolism_Homo sapiens_hsa003300.84138959
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83649679
60Sulfur relay system_Homo sapiens_hsa041220.82839876
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80243528
62One carbon pool by folate_Homo sapiens_hsa006700.77759911
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75764247
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72670462
65Vitamin digestion and absorption_Homo sapiens_hsa049770.70297498
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.69435241
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68998697
68Peroxisome_Homo sapiens_hsa041460.68071438
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67309049
70Glycerolipid metabolism_Homo sapiens_hsa005610.67116355
71Metabolic pathways_Homo sapiens_hsa011000.66901286
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65432395
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65424355
74Epstein-Barr virus infection_Homo sapiens_hsa051690.65183498
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63950046
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.63681257
77Arginine biosynthesis_Homo sapiens_hsa002200.62860505
78N-Glycan biosynthesis_Homo sapiens_hsa005100.62608868
79beta-Alanine metabolism_Homo sapiens_hsa004100.61539394
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60395529
81Tyrosine metabolism_Homo sapiens_hsa003500.59286782
82Alcoholism_Homo sapiens_hsa050340.56968391
83Galactose metabolism_Homo sapiens_hsa000520.55713178
84Fat digestion and absorption_Homo sapiens_hsa049750.55590261
85Fatty acid degradation_Homo sapiens_hsa000710.54039580
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52958176
87Legionellosis_Homo sapiens_hsa051340.51346040
88Amphetamine addiction_Homo sapiens_hsa050310.50484739
89Chemical carcinogenesis_Homo sapiens_hsa052040.49537803
90Fatty acid metabolism_Homo sapiens_hsa012120.48696440
91Viral carcinogenesis_Homo sapiens_hsa052030.48631836
92Hedgehog signaling pathway_Homo sapiens_hsa043400.48478690
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47797116
94p53 signaling pathway_Homo sapiens_hsa041150.47509169
95PPAR signaling pathway_Homo sapiens_hsa033200.45059766
96Renin-angiotensin system_Homo sapiens_hsa046140.44480668
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.42678896
98Mineral absorption_Homo sapiens_hsa049780.41609968
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39344138
100Phenylalanine metabolism_Homo sapiens_hsa003600.37482481
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35917896
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35791359
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.35388153
104Herpes simplex infection_Homo sapiens_hsa051680.31600189
105Sulfur metabolism_Homo sapiens_hsa009200.31371738
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29624936
107HTLV-I infection_Homo sapiens_hsa051660.27728910
108Tryptophan metabolism_Homo sapiens_hsa003800.26832620
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26711456
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20490255
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18469920
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.18093920
113B cell receptor signaling pathway_Homo sapiens_hsa046620.15959199
114Fatty acid elongation_Homo sapiens_hsa000620.15738038
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.11256621
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11023629
117Thyroid hormone synthesis_Homo sapiens_hsa049180.10904850
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.08923128
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08550163
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08496943
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.07875632
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.07181030
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.06824724
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06761795
125Vibrio cholerae infection_Homo sapiens_hsa051100.05887643
126Dorso-ventral axis formation_Homo sapiens_hsa043200.05647805
127Lysine degradation_Homo sapiens_hsa003100.03374654

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