SPATA25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)9.85121745
2cell wall macromolecule metabolic process (GO:0044036)9.85121745
3fusion of sperm to egg plasma membrane (GO:0007342)9.17689641
4sperm-egg recognition (GO:0035036)8.71781963
5acrosome assembly (GO:0001675)8.60074123
6axonemal dynein complex assembly (GO:0070286)8.22349604
7spermatid development (GO:0007286)8.21485765
8binding of sperm to zona pellucida (GO:0007339)8.09187845
9regulation of cilium movement (GO:0003352)7.92283603
10epithelial cilium movement (GO:0003351)7.88696504
11cell-cell recognition (GO:0009988)7.75923730
12multicellular organism reproduction (GO:0032504)7.26486322
13motile cilium assembly (GO:0044458)7.21941298
14plasma membrane fusion (GO:0045026)7.05611578
15microtubule depolymerization (GO:0007019)6.60054343
16negative regulation of inclusion body assembly (GO:0090084)6.49427950
17cilium movement (GO:0003341)6.34730035
18reproduction (GO:0000003)6.30405308
19synaptonemal complex organization (GO:0070193)6.13771303
20synaptonemal complex assembly (GO:0007130)6.10734593
21piRNA metabolic process (GO:0034587)6.05504335
22cilium or flagellum-dependent cell motility (GO:0001539)5.94635398
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.90885568
24male meiosis (GO:0007140)5.71543105
25* spermatogenesis (GO:0007283)5.63742222
26* male gamete generation (GO:0048232)5.62321818
27negative regulation of fibrinolysis (GO:0051918)5.61011520
28sperm capacitation (GO:0048240)5.35289958
29peptidyl-glutamic acid carboxylation (GO:0017187)5.34855883
30protein carboxylation (GO:0018214)5.34855883
31chromosome condensation (GO:0030261)5.32013889
32single fertilization (GO:0007338)5.26288888
33* gamete generation (GO:0007276)5.21591660
34calcium ion-dependent exocytosis (GO:0017156)5.20455645
35DNA packaging (GO:0006323)5.17449838
36regulation of inclusion body assembly (GO:0090083)5.09295066
37organic cation transport (GO:0015695)5.05826629
38spermatid nucleus differentiation (GO:0007289)4.94577549
39very-low-density lipoprotein particle assembly (GO:0034379)4.77010107
40regulation of fibrinolysis (GO:0051917)4.75815844
41protein-lipid complex assembly (GO:0065005)4.74092377
42plasma lipoprotein particle assembly (GO:0034377)4.68301437
43regulation of microtubule-based movement (GO:0060632)4.61252508
44fertilization (GO:0009566)4.57077493
45germ cell development (GO:0007281)4.47420344
46regulation of cholesterol homeostasis (GO:2000188)4.44769404
47glycerol ether metabolic process (GO:0006662)4.41469544
48male meiosis I (GO:0007141)4.38993314
49cellular process involved in reproduction in multicellular organism (GO:0022412)4.32709316
50microtubule severing (GO:0051013)4.26042175
51chromosome organization involved in meiosis (GO:0070192)4.20406191
52DNA methylation involved in gamete generation (GO:0043046)4.19645226
53regulation of apoptotic cell clearance (GO:2000425)4.15496073
54* multicellular organismal reproductive process (GO:0048609)4.09249951
55ether metabolic process (GO:0018904)4.05669266
56meiotic nuclear division (GO:0007126)3.99076634
57positive regulation of fatty acid biosynthetic process (GO:0045723)3.98411974
58cell recognition (GO:0008037)3.97314895
59GTP biosynthetic process (GO:0006183)3.97121625
60low-density lipoprotein particle clearance (GO:0034383)3.94882164
61protein localization to cilium (GO:0061512)3.93503800
62ventricular system development (GO:0021591)3.93064322
63mannose metabolic process (GO:0006013)3.90809836
64seminiferous tubule development (GO:0072520)3.89068801
65microtubule polymerization or depolymerization (GO:0031109)3.86489033
66pinocytosis (GO:0006907)3.84326596
67regulation of plasminogen activation (GO:0010755)3.83577828
68triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.78439121
69nucleoside diphosphate phosphorylation (GO:0006165)3.75977602
70proline metabolic process (GO:0006560)3.74927774
71chaperone-mediated protein complex assembly (GO:0051131)3.74603359
72positive regulation of extracellular matrix organization (GO:1903055)3.73859073
73proline biosynthetic process (GO:0006561)3.73473078
74negative regulation of sterol transport (GO:0032372)3.73116700
75negative regulation of cholesterol transport (GO:0032375)3.73116700
76intestinal cholesterol absorption (GO:0030299)3.72295697
77protein polyglutamylation (GO:0018095)3.72083288
78protein-lipid complex subunit organization (GO:0071825)3.70821756
79plasma lipoprotein particle clearance (GO:0034381)3.70020839
80meiosis I (GO:0007127)3.67170415
81cholesterol efflux (GO:0033344)3.61783241
82protein-lipid complex remodeling (GO:0034368)3.61267759
83macromolecular complex remodeling (GO:0034367)3.61267759
84plasma lipoprotein particle remodeling (GO:0034369)3.61267759
85plasma lipoprotein particle organization (GO:0071827)3.61170263
86regulation of protein activation cascade (GO:2000257)3.57793270
87regulation of cholesterol esterification (GO:0010872)3.50377358
88regulation of complement activation (GO:0030449)3.50237930
89single strand break repair (GO:0000012)3.48967387
90UTP biosynthetic process (GO:0006228)3.48242777
91low-density lipoprotein particle remodeling (GO:0034374)3.47286206
92positive regulation of lipoprotein lipase activity (GO:0051006)3.46915336
93positive regulation of triglyceride lipase activity (GO:0061365)3.46915336
94regulation of fatty acid biosynthetic process (GO:0042304)3.45932304
95guanosine-containing compound biosynthetic process (GO:1901070)3.38180515
96polyamine biosynthetic process (GO:0006596)3.34504402
97basement membrane organization (GO:0071711)3.31494575
98negative regulation of erythrocyte differentiation (GO:0045647)3.26916337
99regulation of cholesterol biosynthetic process (GO:0045540)3.24027945
100complement activation, alternative pathway (GO:0006957)3.22636816
101DNA deamination (GO:0045006)3.18027576
102blood coagulation, intrinsic pathway (GO:0007597)3.16361510
103multicellular organismal development (GO:0007275)3.15855914
104axoneme assembly (GO:0035082)3.15638039
105high-density lipoprotein particle remodeling (GO:0034375)3.14143867
106left/right pattern formation (GO:0060972)3.14100466
107erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.13850832
108L-phenylalanine metabolic process (GO:0006558)3.13850832
109phospholipid efflux (GO:0033700)3.13675980
110histone exchange (GO:0043486)3.10605310
111L-phenylalanine catabolic process (GO:0006559)3.08517669
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.08517669
113RNA destabilization (GO:0050779)3.08315830
114cellular hyperosmotic response (GO:0071474)3.04161346
115dicarboxylic acid biosynthetic process (GO:0043650)3.00172369
116urea cycle (GO:0000050)2.99184542
117negative regulation of lipid transport (GO:0032369)2.98419953
118meiotic cell cycle (GO:0051321)2.97622091
119regulation of extracellular matrix organization (GO:1903053)2.97552016
120UTP metabolic process (GO:0046051)2.96704412
121energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.95972799
122ATP hydrolysis coupled proton transport (GO:0015991)2.95972799
123regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.94425518
124sexual reproduction (GO:0019953)2.94121760
125reverse cholesterol transport (GO:0043691)2.91683144
126regulation of spindle checkpoint (GO:0090231)2.90592816
127response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.89885867
128cilium morphogenesis (GO:0060271)2.88404778
129focal adhesion assembly (GO:0048041)2.88125916
130cell-substrate adherens junction assembly (GO:0007045)2.88125916
131urea metabolic process (GO:0019627)2.86806167
132negative regulation of fatty acid biosynthetic process (GO:0045717)2.86454030
133meiotic cell cycle process (GO:1903046)2.85467876
134protein refolding (GO:0042026)2.84992024
135positive regulation of myotube differentiation (GO:0010831)2.82025604
136mitotic sister chromatid cohesion (GO:0007064)2.81202554
137nucleus organization (GO:0006997)2.79670290
138positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.77620683
139negative regulation of fatty acid transport (GO:2000192)2.77608821
140response to acidic pH (GO:0010447)2.76228296
141regulation of protein kinase A signaling (GO:0010738)2.75646978
142diacylglycerol metabolic process (GO:0046339)2.75012993
143CTP biosynthetic process (GO:0006241)2.73725648
144CTP metabolic process (GO:0046036)2.73725648
145fibrinolysis (GO:0042730)2.72845934
146glutamate metabolic process (GO:0006536)2.72612876
147regulation of cholesterol metabolic process (GO:0090181)2.71074861
148purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.70031472
149cilium organization (GO:0044782)2.69299330
150apoptotic cell clearance (GO:0043277)2.69189245
151regulation of response to osmotic stress (GO:0047484)2.67991771
152oligosaccharide catabolic process (GO:0009313)2.67196966
153cilium assembly (GO:0042384)2.66048724
154regulation of extracellular matrix disassembly (GO:0010715)2.65515799
155sequestering of actin monomers (GO:0042989)2.65505031
156acute-phase response (GO:0006953)2.65020974
157regulation of cholesterol storage (GO:0010885)2.64247192
158negative regulation of cell size (GO:0045792)2.62995368
159embryonic process involved in female pregnancy (GO:0060136)2.62493099
160hyaluronan metabolic process (GO:0030212)2.62318665
161lipoprotein metabolic process (GO:0042157)2.60820882
162purine nucleoside triphosphate biosynthetic process (GO:0009145)2.60683218
163positive regulation of blood coagulation (GO:0030194)2.60374506
164positive regulation of hemostasis (GO:1900048)2.60374506
165adherens junction assembly (GO:0034333)2.60035698
166positive regulation of systemic arterial blood pressure (GO:0003084)2.59956071
167oxaloacetate metabolic process (GO:0006107)2.58144586
168negative regulation of hemostasis (GO:1900047)2.57141291
169negative regulation of blood coagulation (GO:0030195)2.57141291
170negative regulation of granulocyte differentiation (GO:0030853)2.56668528
171positive regulation of phagocytosis (GO:0050766)2.56124540
172peptidyl-threonine dephosphorylation (GO:0035970)2.55749612
173regulation of meiosis I (GO:0060631)2.55361929
174regulation of skeletal muscle contraction (GO:0014819)2.55103037
175drinking behavior (GO:0042756)2.53409051
176nitrogen cycle metabolic process (GO:0071941)2.52108869
177regulation of mammary gland epithelial cell proliferation (GO:0033599)2.52040807
1782-oxoglutarate metabolic process (GO:0006103)2.51836551
179response to muscle activity (GO:0014850)2.51643002
180positive regulation of steroid metabolic process (GO:0045940)2.50728369
181skeletal muscle contraction (GO:0003009)2.49363500
182alpha-linolenic acid metabolic process (GO:0036109)2.48114362
183urinary tract smooth muscle contraction (GO:0014848)2.47912879
184activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.47363459
185pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.46698406
186regulation of glucose import in response to insulin stimulus (GO:2001273)2.46497332
187pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.46107558
188fatty acid homeostasis (GO:0055089)2.45878696
189tricarboxylic acid metabolic process (GO:0072350)2.45175050
190protein retention in ER lumen (GO:0006621)2.44784960
191intestinal absorption (GO:0050892)2.44327110
192positive regulation of lipid storage (GO:0010884)2.44301165
193protein complex localization (GO:0031503)2.44106778
194ERK1 and ERK2 cascade (GO:0070371)2.44095817
195nucleoside triphosphate biosynthetic process (GO:0009142)2.43675888
196protein insertion into membrane (GO:0051205)2.42666976
197cellular component assembly involved in morphogenesis (GO:0010927)2.39733342
198negative regulation of appetite (GO:0032099)2.38595262
199sperm motility (GO:0030317)11.2243972
200acrosome reaction (GO:0007340)10.2839941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.31763596
2EZH2_22144423_ChIP-Seq_EOC_Human5.51956257
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.60590654
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.19789502
5VDR_21846776_ChIP-Seq_THP-1_Human3.15565597
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.06799749
7LXR_22292898_ChIP-Seq_THP-1_Human2.91391573
8MYC_22102868_ChIP-Seq_BL_Human2.83486146
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.72427738
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60877931
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.53704181
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53476351
13VDR_22108803_ChIP-Seq_LS180_Human2.49620557
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49593405
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.45360064
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34924279
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.33305561
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.30031706
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24511867
20PPARA_22158963_ChIP-Seq_LIVER_Mouse2.22549414
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.22138398
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.21919162
23KDM2B_26808549_Chip-Seq_SUP-B15_Human2.19056229
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18285776
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18048434
26ZNF263_19887448_ChIP-Seq_K562_Human2.15664999
27TCF7_22412390_ChIP-Seq_EML_Mouse2.13806288
28CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.12207280
29RACK7_27058665_Chip-Seq_MCF-7_Human2.08045696
30GATA1_26923725_Chip-Seq_HPCs_Mouse2.02823874
31TP63_17297297_ChIP-ChIP_HaCaT_Human2.01879554
32TAF15_26573619_Chip-Seq_HEK293_Human1.98133971
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.95267758
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91741802
35REST_21632747_ChIP-Seq_MESCs_Mouse1.89894101
36KDM2B_26808549_Chip-Seq_DND41_Human1.87234508
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86724463
38SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.81011450
39P68_20966046_ChIP-Seq_HELA_Human1.78360395
40KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70102605
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67475395
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.66892235
43CLOCK_20551151_ChIP-Seq_293T_Human1.66277490
44ZNF274_21170338_ChIP-Seq_K562_Hela1.66253799
45ELK4_26923725_Chip-Seq_MESODERM_Mouse1.65560452
46FUS_26573619_Chip-Seq_HEK293_Human1.65129236
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63969122
48VDR_24763502_ChIP-Seq_THP-1_Human1.62745670
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62582054
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.61233822
51GATA3_21867929_ChIP-Seq_CD8_Mouse1.58273681
52MAF_26560356_Chip-Seq_TH1_Human1.57610234
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55203158
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.54392824
55SMC4_20622854_ChIP-Seq_HELA_Human1.52741380
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51377230
57KDM2B_26808549_Chip-Seq_K562_Human1.49018111
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48173285
59MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47358202
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.45707661
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.45653480
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45191679
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45006999
64STAT1_17558387_ChIP-Seq_HELA_Human1.44276185
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44027736
66MAF_26560356_Chip-Seq_TH2_Human1.43763315
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43467720
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42315725
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41912908
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41805264
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40497020
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.40229349
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38301845
74SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.37378476
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36924684
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36368289
77TP53_22127205_ChIP-Seq_IMR90_Human1.35971524
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.35763479
79FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35477942
80BCOR_27268052_Chip-Seq_Bcells_Human1.34924125
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31480742
82FOXA2_19822575_ChIP-Seq_HepG2_Human1.29005079
83FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28821575
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28778880
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28361965
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28196313
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27838083
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27528253
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.27367464
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26657089
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.26574070
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26455485
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26370854
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26094091
95RNF2_27304074_Chip-Seq_NSC_Mouse1.25860599
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25321347
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25238541
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25238541
99GATA3_21867929_ChIP-Seq_TH1_Mouse1.25023093
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.23916164
101CREB1_26743006_Chip-Seq_LNCaP_Human1.23781474
102KDM2B_26808549_Chip-Seq_REH_Human1.23446067
103KAP1_22055183_ChIP-Seq_ESCs_Mouse1.21886251
104NCOR1_26117541_ChIP-Seq_K562_Human1.21746209
105UTX_26944678_Chip-Seq_JUKART_Human1.21689223
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21636787
107ATF3_27146783_Chip-Seq_COLON_Human1.19924551
108GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.19356560
109P53_21459846_ChIP-Seq_SAOS-2_Human1.19225396
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.19071914
111SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18900765
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18560097
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17423747
114KDM2B_26808549_Chip-Seq_JURKAT_Human1.16613618
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16441197
116RARA_24833708_ChIP-Seq_LIVER_Mouse1.15722731
117CBX2_27304074_Chip-Seq_ESCs_Mouse1.15642171
118GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15635053
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15095345
120JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15074805
121SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14578956
122KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13615249
123NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12965749
124P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12724898
125RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12355955
126BCL6_27268052_Chip-Seq_Bcells_Human1.11485627
127TET1_21451524_ChIP-Seq_MESCs_Mouse1.11318185
128RARB_24833708_ChIP-Seq_LIVER_Mouse1.11011699
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10361562
130CTCF_27219007_Chip-Seq_Bcells_Human1.09830213
131UBF1/2_26484160_Chip-Seq_HMECs_Human1.09646113
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08925981
133IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08321069
134CBP_20019798_ChIP-Seq_JUKART_Human1.08321069
135TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07545204
136NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07485614
137CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07255360
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06379478
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06160997
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06069054
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05767181
142ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05654666
143NANOG_18555785_Chip-Seq_ESCs_Mouse1.05434270
144SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04965313
145KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04437122
146CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04421781
147CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04124736
148LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.03542555
149RUNX1_22412390_ChIP-Seq_EML_Mouse1.03142395
150SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02625697
151SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02563896
152NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02366084
153PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02000598
154DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01840654
155CTCF_21964334_Chip-Seq_Bcells_Human1.01486584
156E2F1_20622854_ChIP-Seq_HELA_Human1.00963495
157MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00943567
158CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99914047
159NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99149453
160P53_22387025_ChIP-Seq_ESCs_Mouse0.98539790
161REST_18959480_ChIP-ChIP_MESCs_Mouse0.97886272
162YY1_22570637_ChIP-Seq_MALME-3M_Human0.97474633
163RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96830001
164WDR5_24793694_ChIP-Seq_LNCAP_Human0.95369516
165SOX9_26525672_Chip-Seq_HEART_Mouse0.94655261
166PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94398419
167FLI1_21867929_ChIP-Seq_TH2_Mouse0.93815301
168CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93325584
169E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.92916088
170ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92068952
171SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92004872
172PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91798225
173CRX_20693478_ChIP-Seq_RETINA_Mouse0.91727427
174CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91692506
175JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.90285153
176NANOG_20526341_ChIP-Seq_ESCs_Human0.89595993
177SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89464901
178LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88852267
179RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88551318
180CMYC_18555785_Chip-Seq_ESCs_Mouse0.86607558
181ETV1_20927104_ChIP-Seq_GIST48_Human0.85509827
182CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85178521
183TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84937554
184SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84933975
185PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84438216
186OCT4_18555785_Chip-Seq_ESCs_Mouse0.84397093
187ERG_20517297_ChIP-Seq_VCAP_Human0.84068067
188EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84016674
189CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.83832995
190SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83676095
191CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83604096
192CTCF_20526341_ChIP-Seq_ESCs_Human0.83054877
193SPI1_26923725_Chip-Seq_HPCs_Mouse0.82811697
194NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82636255
195SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82512456
196EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82499517
197YY1_21170310_ChIP-Seq_MESCs_Mouse0.82344831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.84173214
2MP0001929_abnormal_gametogenesis4.47796879
3MP0008877_abnormal_DNA_methylation4.20293386
4MP0002139_abnormal_hepatobiliary_system3.93782830
5MP0005360_urolithiasis3.61623738
6MP0005058_abnormal_lysosome_morphology3.59329272
7MP0009840_abnormal_foam_cell3.33700374
8MP0000751_myopathy2.81755197
9MP0005365_abnormal_bile_salt2.79736188
10MP0002210_abnormal_sex_determination2.79496130
11MP0003705_abnormal_hypodermis_morpholog2.78154984
12MP0001984_abnormal_olfaction2.75469839
13MP0002161_abnormal_fertility/fecundity2.66138625
14MP0003172_abnormal_lysosome_physiology2.62484436
15MP0005076_abnormal_cell_differentiation2.50486442
16MP0001145_abnormal_male_reproductive2.40135436
17MP0003436_decreased_susceptibility_to2.14617603
18MP0002822_catalepsy2.05563378
19MP0000653_abnormal_sex_gland2.04667753
20MP0005410_abnormal_fertilization12.7707579
21MP0005670_abnormal_white_adipose1.94935519
22MP0003880_abnormal_central_pattern1.92706844
23MP0009379_abnormal_foot_pigmentation1.91793878
24MP0002089_abnormal_postnatal_growth/wei1.88114662
25MP0004185_abnormal_adipocyte_glucose1.83905901
26MP0000747_muscle_weakness1.81023168
27MP0001968_abnormal_touch/_nociception1.76856596
28MP0003566_abnormal_cell_adhesion1.75076041
29MP0006276_abnormal_autonomic_nervous1.72624732
30MP0010329_abnormal_lipoprotein_level1.71615440
31MP0005330_cardiomyopathy1.71340671
32MP0004087_abnormal_muscle_fiber1.70499640
33MP0003693_abnormal_embryo_hatching1.69272499
34MP0008875_abnormal_xenobiotic_pharmacok1.67101744
35MP0001661_extended_life_span1.66403771
36MP0001529_abnormal_vocalization1.65438778
37MP0002736_abnormal_nociception_after1.64324926
38MP0003191_abnormal_cellular_cholesterol1.56982479
39MP0009278_abnormal_bone_marrow1.53068321
40MP0005257_abnormal_intraocular_pressure1.50725703
41MP0000759_abnormal_skeletal_muscle1.50690305
42MP0009046_muscle_twitch1.50168210
43MP0002160_abnormal_reproductive_system1.48752150
44MP0001666_abnormal_nutrient_absorption1.48299817
45MP0008438_abnormal_cutaneous_collagen1.47839812
46MP0004130_abnormal_muscle_cell1.45612558
47MP0010630_abnormal_cardiac_muscle1.45124564
48MP0000749_muscle_degeneration1.44754304
49MP0003879_abnormal_hair_cell1.44189506
50MP0001915_intracranial_hemorrhage1.44004160
51MP0003646_muscle_fatigue1.43597963
52MP0003635_abnormal_synaptic_transmissio1.41989820
53MP0002106_abnormal_muscle_physiology1.39960751
54MP0003656_abnormal_erythrocyte_physiolo1.39747713
55MP0005499_abnormal_olfactory_system1.39000301
56MP0005394_taste/olfaction_phenotype1.39000301
57MP0008789_abnormal_olfactory_epithelium1.36743233
58MP0005666_abnormal_adipose_tissue1.36294758
59MP0000003_abnormal_adipose_tissue1.35537332
60MP0003123_paternal_imprinting1.35216976
61MP0000609_abnormal_liver_physiology1.32924435
62MP0002234_abnormal_pharynx_morphology1.32199588
63MP0002269_muscular_atrophy1.30910296
64MP0002132_abnormal_respiratory_system1.30819429
65MP0003868_abnormal_feces_composition1.28672312
66MP0004957_abnormal_blastocyst_morpholog1.28469039
67MP0008260_abnormal_autophagy1.27802700
68MP0003183_abnormal_peptide_metabolism1.27557599
69MP0000858_altered_metastatic_potential1.27002933
70MP0005645_abnormal_hypothalamus_physiol1.26785977
71MP0003091_abnormal_cell_migration1.26702347
72MP0000733_abnormal_muscle_development1.24865875
73MP0002572_abnormal_emotion/affect_behav1.22688094
74MP0003453_abnormal_keratinocyte_physiol1.22237904
75MP0003787_abnormal_imprinting1.21070646
76MP0001440_abnormal_grooming_behavior1.20110458
77MP0000750_abnormal_muscle_regeneration1.19122916
78MP0005375_adipose_tissue_phenotype1.18744817
79MP0010094_abnormal_chromosome_stability1.18546970
80MP0008995_early_reproductive_senescence1.16497627
81MP0001188_hyperpigmentation1.14920669
82MP0002877_abnormal_melanocyte_morpholog1.12079203
83MP0005409_darkened_coat_color1.11893861
84MP0008058_abnormal_DNA_repair1.11851263
85MP0001849_ear_inflammation1.11239779
86MP0005085_abnormal_gallbladder_physiolo1.10456476
87MP0009745_abnormal_behavioral_response1.10231131
88MP0005369_muscle_phenotype1.10130694
89MP0003300_gastrointestinal_ulcer1.08814095
90MP0010368_abnormal_lymphatic_system1.07801708
91MP0002118_abnormal_lipid_homeostasis1.07772053
92MP0000604_amyloidosis1.07668354
93MP0002009_preneoplasia1.07491537
94MP0003303_peritoneal_inflammation1.07207914
95MP0002063_abnormal_learning/memory/cond1.07039781
96MP0002971_abnormal_brown_adipose1.06705631
97MP0009384_cardiac_valve_regurgitation1.06593381
98MP0000685_abnormal_immune_system1.05610639
99MP0002933_joint_inflammation1.05256713
100MP0001486_abnormal_startle_reflex1.04659047
101MP0001727_abnormal_embryo_implantation1.04494740
102MP0006072_abnormal_retinal_apoptosis1.04262854
103MP0002272_abnormal_nervous_system1.02615589
104MP0005332_abnormal_amino_acid1.01843171
105MP0005083_abnormal_biliary_tract1.00480836
106MP0005464_abnormal_platelet_physiology1.00231812
107MP0002064_seizures0.99490051
108MP0003315_abnormal_perineum_morphology0.99383766
109MP0001765_abnormal_ion_homeostasis0.98985735
110MP0006292_abnormal_olfactory_placode0.96735144
111MP0001905_abnormal_dopamine_level0.95639404
112MP0002837_dystrophic_cardiac_calcinosis0.95516720
113MP0003786_premature_aging0.95368859
114MP0003111_abnormal_nucleus_morphology0.95197595
115MP0000678_abnormal_parathyroid_gland0.94844532
116MP0004858_abnormal_nervous_system0.94408859
117MP0002249_abnormal_larynx_morphology0.89935469
118MP0006138_congestive_heart_failure0.89811742
119MP0003195_calcinosis0.89575540
120MP0002735_abnormal_chemical_nociception0.89271496
121MP0005584_abnormal_enzyme/coenzyme_acti0.89091621
122MP0001986_abnormal_taste_sensitivity0.88426168
123MP0003329_amyloid_beta_deposits0.88087392
124MP0002998_abnormal_bone_remodeling0.88073902
125MP0004859_abnormal_synaptic_plasticity0.88043723
126MP0000631_abnormal_neuroendocrine_gland0.87046348
127MP0005023_abnormal_wound_healing0.86119140
128MP0000598_abnormal_liver_morphology0.85333981
129MP0002102_abnormal_ear_morphology0.83461424
130MP0005367_renal/urinary_system_phenotyp0.83325286
131MP0000516_abnormal_urinary_system0.83325286
132MP0000767_abnormal_smooth_muscle0.83051122
133MP0004233_abnormal_muscle_weight0.80800249
134MP0003121_genomic_imprinting0.80618212
135MP0005319_abnormal_enzyme/_coenzyme0.79408050
136MP0004043_abnormal_pH_regulation0.79405171
137MP0002067_abnormal_sensory_capabilities0.78588121
138MP0002396_abnormal_hematopoietic_system0.78338779
139MP0005389_reproductive_system_phenotype0.78077659
140MP0002909_abnormal_adrenal_gland0.78009814
141MP0002184_abnormal_innervation0.76397425
142MP0005551_abnormal_eye_electrophysiolog0.75738291
143MP0003075_altered_response_to0.75533631
144MP0002254_reproductive_system_inflammat0.75373243
145MP0002734_abnormal_mechanical_nocicepti0.74481231
146MP0008469_abnormal_protein_level0.73346697
147MP0006035_abnormal_mitochondrial_morpho0.73292968
148MP0001533_abnormal_skeleton_physiology0.73291292
149MP0004510_myositis0.73004921
150MP0004084_abnormal_cardiac_muscle0.71785590
151MP0006036_abnormal_mitochondrial_physio0.71607322
152MP0005423_abnormal_somatic_nervous0.70713028
153MP0003115_abnormal_respiratory_system0.70507494
154MP0003567_abnormal_fetal_cardiomyocyte0.70399065
155MP0010386_abnormal_urinary_bladder0.69454846
156MP0002128_abnormal_blood_circulation0.68805067
157MP0004142_abnormal_muscle_tone0.65965413
158MP0003077_abnormal_cell_cycle0.65355012
159MP0005621_abnormal_cell_physiology0.64867849
160MP0004270_analgesia0.64158723
161MP0004811_abnormal_neuron_physiology0.63550507
162MP0004272_abnormal_basement_membrane0.63292324
163MP0004947_skin_inflammation0.62367264
164MP0002166_altered_tumor_susceptibility0.60964369
165MP0003718_maternal_effect0.60229359
166MP0009643_abnormal_urine_homeostasis0.60043178
167MP0003279_aneurysm0.59983351
168MP0001348_abnormal_lacrimal_gland0.59544971
169MP0003119_abnormal_digestive_system0.59188687
170MP0002557_abnormal_social/conspecific_i0.58465455
171MP0002896_abnormal_bone_mineralization0.58405953
172MP0008007_abnormal_cellular_replicative0.56853431
173MP0005623_abnormal_meninges_morphology0.55405120
174MP0005451_abnormal_body_composition0.55244865
175MP0003122_maternal_imprinting0.55062875
176MP0002752_abnormal_somatic_nervous0.55026756
177MP0004036_abnormal_muscle_relaxation0.54940379
178MP0000013_abnormal_adipose_tissue0.53865647
179MP0001730_embryonic_growth_arrest0.52841650
180MP0005253_abnormal_eye_physiology0.52353519
181MP0008932_abnormal_embryonic_tissue0.52338630
182MP0002152_abnormal_brain_morphology0.52028664
183MP0004133_heterotaxia0.51844190
184MP0001502_abnormal_circadian_rhythm0.51742049
185MP0001293_anophthalmia0.51151368
186MP0002882_abnormal_neuron_morphology0.47984146
187MP0002638_abnormal_pupillary_reflex0.47449230
188MP0000015_abnormal_ear_pigmentation0.46718025
189MP0002066_abnormal_motor_capabilities/c0.46068923
190MP0004924_abnormal_behavior0.45589327
191MP0005386_behavior/neurological_phenoty0.45589327
192MP0000358_abnormal_cell_content/0.45323538

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.99387823
2Abnormal respiratory motile cilium physiology (HP:0012261)7.87560183
3Abnormal respiratory epithelium morphology (HP:0012253)7.87203416
4Abnormal respiratory motile cilium morphology (HP:0005938)7.87203416
5Abnormal ciliary motility (HP:0012262)6.33593095
6Chronic bronchitis (HP:0004469)6.26814499
7Infertility (HP:0000789)6.17852003
8Rhinitis (HP:0012384)6.16623837
9Deep venous thrombosis (HP:0002625)5.95631639
10Nasal polyposis (HP:0100582)4.31136625
11Joint hemorrhage (HP:0005261)4.20563678
12Nephronophthisis (HP:0000090)4.06690880
13Hemorrhage of the eye (HP:0011885)4.04941986
14Abnormal spermatogenesis (HP:0008669)4.01667146
15Prolonged partial thromboplastin time (HP:0003645)3.89878116
16Exercise-induced myalgia (HP:0003738)3.80185667
17Abnormality of midbrain morphology (HP:0002418)3.69550220
18Molar tooth sign on MRI (HP:0002419)3.69550220
19Bronchiectasis (HP:0002110)3.61859604
20Male infertility (HP:0003251)3.54966856
21Medial flaring of the eyebrow (HP:0010747)3.44732524
22Double outlet right ventricle (HP:0001719)3.41662387
23Congenital malformation of the right heart (HP:0011723)3.41662387
24Bronchitis (HP:0012387)3.36127253
25Protrusio acetabuli (HP:0003179)3.34163137
26Abnormality of the nasal mucosa (HP:0000433)3.32634712
27Atonic seizures (HP:0010819)3.26951813
28Complement deficiency (HP:0004431)3.24978125
29Xanthomatosis (HP:0000991)3.17645592
30Impulsivity (HP:0100710)3.16756235
31Sensory axonal neuropathy (HP:0003390)3.01605802
32Abnormality of complement system (HP:0005339)2.93776259
33Muscle fiber inclusion bodies (HP:0100299)2.93249638
34Abnormality of the renal medulla (HP:0100957)2.88918987
35Focal motor seizures (HP:0011153)2.87959600
36Abnormality of the common coagulation pathway (HP:0010990)2.87647337
37Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.86961869
38Nemaline bodies (HP:0003798)2.85299912
39Hypercholesterolemia (HP:0003124)2.85030593
40Myopathic facies (HP:0002058)2.84129474
41Azoospermia (HP:0000027)2.80431693
42Thin bony cortex (HP:0002753)2.79759679
43Ulnar bowing (HP:0003031)2.79160393
44Systemic lupus erythematosus (HP:0002725)2.78249189
45Congenital primary aphakia (HP:0007707)2.73358911
46Gait imbalance (HP:0002141)2.71899260
47Asymmetric septal hypertrophy (HP:0001670)2.68731750
48Pancreatic fibrosis (HP:0100732)2.68667863
49Abnormality of the Achilles tendon (HP:0005109)2.67258567
50Centrally nucleated skeletal muscle fibers (HP:0003687)2.62171484
51Type 1 muscle fiber predominance (HP:0003803)2.60925566
52Hypobetalipoproteinemia (HP:0003563)2.59413342
53Nephrogenic diabetes insipidus (HP:0009806)2.54983932
54Distal lower limb amyotrophy (HP:0008944)2.52690138
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51140257
56Hyperacusis (HP:0010780)2.49719988
57True hermaphroditism (HP:0010459)2.49412258
58Ulnar deviation of the wrist (HP:0003049)2.48704216
59Recurrent otitis media (HP:0000403)2.44113816
60Distal lower limb muscle weakness (HP:0009053)2.39765666
61Achilles tendon contracture (HP:0001771)2.39661017
62Myocardial infarction (HP:0001658)2.39549019
63Hypoalphalipoproteinemia (HP:0003233)2.38804171
64Dysostosis multiplex (HP:0000943)2.38384130
65Pancreatic cysts (HP:0001737)2.37067645
66Flat acetabular roof (HP:0003180)2.35650050
67Tubulointerstitial nephritis (HP:0001970)2.32703850
68Hypolipoproteinemia (HP:0010981)2.32242168
69Increased connective tissue (HP:0009025)2.30825771
70Menorrhagia (HP:0000132)2.30643848
71Cerebral aneurysm (HP:0004944)2.28656937
72Urinary glycosaminoglycan excretion (HP:0003541)2.26903628
73Mucopolysacchariduria (HP:0008155)2.26903628
74Vertebral compression fractures (HP:0002953)2.24444178
75Ragged-red muscle fibers (HP:0003200)2.24114700
76Glomerulonephritis (HP:0000099)2.23916562
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.23592147
78Abnormality of polysaccharide metabolism (HP:0011012)2.23592147
79Abnormality of glycosaminoglycan metabolism (HP:0004371)2.23592147
80Round ear (HP:0100830)2.20159827
81Vaginal fistula (HP:0004320)2.19594883
82Aplasia/Hypoplasia of the lens (HP:0008063)2.16338434
83Broad face (HP:0000283)2.16014964
84Recurrent sinusitis (HP:0011108)2.11616516
85Abnormality of the intrinsic pathway (HP:0010989)2.10814771
86Asymmetry of the thorax (HP:0001555)2.10186459
87Vaginal atresia (HP:0000148)2.09874404
88Polyphagia (HP:0002591)2.09720162
89Oculomotor apraxia (HP:0000657)2.05101361
90Genital tract atresia (HP:0001827)2.05070582
91Rhabdomyolysis (HP:0003201)2.04304921
92Postaxial foot polydactyly (HP:0001830)2.04025690
93Abnormality of skeletal muscle fiber size (HP:0012084)2.03721653
94Abnormality of aromatic amino acid family metabolism (HP:0004338)2.02753144
95Purpura (HP:0000979)2.01846498
96Poor coordination (HP:0002370)2.00615339
97Dynein arm defect of respiratory motile cilia (HP:0012255)10.6850719
98Absent/shortened dynein arms (HP:0200106)10.6850719
99Malignant hyperthermia (HP:0002047)1.99861708
100Tubular atrophy (HP:0000092)1.98819506
101Back pain (HP:0003418)1.96568768
102Absence seizures (HP:0002121)1.95632951
103Increased variability in muscle fiber diameter (HP:0003557)1.91333320
104Abnormality of carpal bone ossification (HP:0006257)1.88986500
105Abnormality of the thoracic spine (HP:0100711)1.88227057
106Biconcave vertebral bodies (HP:0004586)1.87813246
107Gonadotropin excess (HP:0000837)1.85284283
108Hypophosphatemic rickets (HP:0004912)1.83460622
109Transposition of the great arteries (HP:0001669)1.83345565
110Abnormal connection of the cardiac segments (HP:0011545)1.83345565
111Abnormal ventriculo-arterial connection (HP:0011563)1.83345565
112Acute necrotizing encephalopathy (HP:0006965)1.82669010
113Joint stiffness (HP:0001387)1.82266924
114EMG: myopathic abnormalities (HP:0003458)1.81381189
115Turricephaly (HP:0000262)1.81004017
116Progressive muscle weakness (HP:0003323)1.80718653
117Premature rupture of membranes (HP:0001788)1.80387594
118Neurofibrillary tangles (HP:0002185)1.80358156
119Bifid tongue (HP:0010297)1.79777787
120Distal upper limb amyotrophy (HP:0007149)1.79179379
121Upper limb amyotrophy (HP:0009129)1.79179379
122Hypertriglyceridemia (HP:0002155)1.78216017
123Choroideremia (HP:0001139)1.78006799
124Cervical subluxation (HP:0003308)1.77059351
125Muscle stiffness (HP:0003552)1.77034108
126Postaxial hand polydactyly (HP:0001162)1.76999272
127Abnormality of the calcaneus (HP:0008364)1.76977027
128Mildly elevated creatine phosphokinase (HP:0008180)1.74809673
129Short tibia (HP:0005736)1.74601640
130Cystic liver disease (HP:0006706)1.73882099
131Intestinal fistula (HP:0100819)1.73880213
132Stridor (HP:0010307)1.72171934
133Cleft eyelid (HP:0000625)1.72068216
134Upper limb muscle weakness (HP:0003484)1.71909068
135Thin ribs (HP:0000883)1.71718161
136Broad palm (HP:0001169)1.71685862
137Decreased central vision (HP:0007663)1.71355635
138Abnormality of the lumbar spine (HP:0100712)1.71282202
139Elevated alkaline phosphatase (HP:0003155)1.70671927
140Seborrheic dermatitis (HP:0001051)1.70128982
141Facial cleft (HP:0002006)1.69856197
142Skin nodule (HP:0200036)1.69250931
143Supernumerary spleens (HP:0009799)1.68926595
144Tubulointerstitial abnormality (HP:0001969)1.66952231
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65669855
146Abnormality of the renal cortex (HP:0011035)1.65294601
147Epileptic encephalopathy (HP:0200134)1.65194125
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.65170584
149Progressive cerebellar ataxia (HP:0002073)1.65033735
150Abnormal ossification of hand bones (HP:0005921)1.64964517
151Dialeptic seizures (HP:0011146)1.64882739
152Congenital hepatic fibrosis (HP:0002612)1.64664429
153Aneurysm (HP:0002617)1.64427046
154Retinal dysplasia (HP:0007973)1.64375477
155Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.63434554
156Abnormal mitochondria in muscle tissue (HP:0008316)1.63033632
157Thoracic kyphosis (HP:0002942)1.62367877
158Bulbar palsy (HP:0001283)1.61925459
159Increased serum ferritin (HP:0003281)1.61713059
160Lower limb amyotrophy (HP:0007210)1.61037629
161Hyporeflexia of lower limbs (HP:0002600)1.60814285
162Febrile seizures (HP:0002373)1.59894916
163Myoglobinuria (HP:0002913)1.59847302
164Dislocated radial head (HP:0003083)1.59457601
165Arterial tortuosity (HP:0005116)1.59368185
166Stage 5 chronic kidney disease (HP:0003774)1.59239575
167Abnormal hair whorl (HP:0010721)1.58646853
168Aplasia/Hypoplasia of the tibia (HP:0005772)1.58460670
169Reticulocytosis (HP:0001923)1.58456810
170Abnormality of the tricuspid valve (HP:0001702)1.57628554
171Truncus arteriosus (HP:0001660)1.57603038
172Spontaneous abortion (HP:0005268)1.56798234
173Easy fatigability (HP:0003388)1.56507951
174Abnormality of the acetabulum (HP:0003170)1.56020603
175Hyperlipoproteinemia (HP:0010980)1.54764384
176Neck muscle weakness (HP:0000467)1.54478438
177Abnormality of the fingertips (HP:0001211)1.53442371
178Long foot (HP:0001833)1.53180901
179Optic disc pallor (HP:0000543)1.52203858
180Abnormal drinking behavior (HP:0030082)1.51756917
181Polydipsia (HP:0001959)1.51756917
182Aganglionic megacolon (HP:0002251)1.51001745
183Dyschromatopsia (HP:0007641)1.50150582
184Spastic tetraparesis (HP:0001285)1.49289189
185Progressive external ophthalmoplegia (HP:0000590)1.48830935
186Anencephaly (HP:0002323)1.47001659
187Median cleft lip (HP:0000161)1.45893413
188Acute encephalopathy (HP:0006846)1.45745397
189Glucose intolerance (HP:0000833)1.44343704
190Retinitis pigmentosa (HP:0000510)1.44179537
191Abnormal number of erythroid precursors (HP:0012131)1.43873339
192Recurrent bronchitis (HP:0002837)1.42335755
193Broad distal phalanx of finger (HP:0009836)1.42085094
194Abnormality of cells of the erythroid lineage (HP:0012130)1.41780989
195Broad foot (HP:0001769)1.41310545
196Sclerocornea (HP:0000647)1.39644224
197Cerebral inclusion bodies (HP:0100314)1.38512984
198Male pseudohermaphroditism (HP:0000037)1.35307983
199Hemiparesis (HP:0001269)1.34560844
200Short femoral neck (HP:0100864)1.33850314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.14493975
2PDK46.14493975
3TESK14.76420429
4TRIB34.41947100
5PDK23.93028788
6PRKD33.34862076
7ICK3.23614376
8FGFR43.13125363
9ERN13.02276670
10PNCK2.94404935
11EEF2K2.79086641
12CAMKK22.75992061
13TTN2.73153075
14CDK122.67658503
15PRPF4B2.67011961
16SMG12.60238981
17IRAK32.57570368
18SIK12.45812593
19MAP2K32.24839706
20RIPK12.22801629
21WEE12.13220944
22ARAF2.03812689
23RIPK41.95249378
24PDGFRA1.91591610
25BUB11.86204162
26STK161.84516254
27CCNB11.73602622
28STK381.71313086
29WNK41.68760106
30MAP2K71.67516689
31CAMK1G1.64898281
32NEK21.59148320
33OBSCN1.56628576
34PTK2B1.55954118
35TLK11.52251149
36MAP3K71.51580360
37TBK11.50187415
38CAMK1D1.49822449
39BRAF1.46059567
40MAP4K11.43851871
41NTRK31.43791239
42MAPK111.42986464
43TTK1.39639568
44DDR21.35120313
45FGFR31.34380993
46MAP3K41.34236316
47STK391.30588507
48NME11.22136765
49PKN21.20570683
50MARK21.20165996
51CASK1.19698726
52TAOK21.19625035
53MAP3K91.17542646
54MTOR1.17104262
55MAP3K101.12350671
56CAMKK11.12320082
57SIK21.11064486
58CDC42BPA1.09860266
59AKT31.08313034
60CDK41.05697686
61MAPK121.05371450
62NME21.04593541
63PLK41.04307645
64TYRO31.00495851
65MELK1.00452112
66MAP3K140.95130809
67BMPR1B0.92280235
68BRSK20.92277418
69EIF2AK10.89208447
70PDK10.88071169
71MAPK150.87404602
72CHEK20.87263378
73PRKD20.86996021
74NEK90.86367657
75AURKA0.86257400
76CDK80.84531399
77PRKAA20.84160787
78CDK70.83981314
79DYRK1B0.83018354
80DYRK30.82891675
81ZAP700.77991298
82TYK20.76986011
83FGR0.74965759
84JAK30.74331859
85MAP3K30.72355795
86CDK60.72024750
87PLK10.70989448
88TESK20.69624606
89MST1R0.69509991
90PDPK10.68994589
91PRKCG0.67829894
92BLK0.67551810
93PINK10.66763837
94EPHA20.65999767
95MAP3K10.64307565
96EPHB20.64101108
97MAP3K110.63887378
98RPS6KC10.63432411
99RPS6KL10.63432411
100AKT20.60761266
101VRK10.60012253
102WNK10.59717021
103MINK10.58942349
104GRK70.58302762
105RPS6KA20.57600783
106TGFBR20.56523287
107GRK60.55397642
108CDC70.54498461
109PASK0.54406913
110RET0.54345085
111YES10.53981894
112PHKG10.53771094
113PHKG20.53771094
114EPHA40.53653245
115PTK20.53612689
116NTRK20.52542348
117CHEK10.52408977
118CSF1R0.51150115
119BMX0.49977086
120PRKAA10.49540013
121TRPM70.49010784
122CAMK40.48805412
123NTRK10.48686179
124CDK90.47586974
125MOS0.47491802
126IRAK10.47361506
127PAK60.45491400
128RPS6KB20.45113841
129PAK10.43714004
130HIPK20.43628347
131RPS6KA60.43231379
132PLK30.43176938
133MET0.42992441
134PTK60.42338427
135ADRBK20.41896589
136GRK50.41738814
137STK38L0.41361399
138TAOK10.40498159
139PLK20.39769755
140PAK40.38910973
141PIM20.38585525
142KSR20.37742564
143ATR0.37211959
144MAP3K50.36342743
145SGK30.35983504
146MAP2K40.35299721
147MATK0.34309612
148LMTK20.34226149
149PDGFRB0.33124639
150CAMK2A0.33114452
151BRD40.31091125
152CSNK2A10.30808990
153JAK10.30774256
154IRAK20.29395841
155MUSK0.27419574
156SRPK10.26340067
157DAPK10.26312409
158CAMK10.25005963
159BRSK10.24892081
160CDK150.24841317
161CDK180.24734361
162CSNK2A20.23989408
163MAPKAPK30.23893282
164ATM0.23618930
165MAP2K60.21919286
166MKNK20.21374898
167ZAK0.20872445
168PRKG20.20674444
169RAF10.20471676
170CDK140.19811006
171CDK11A0.19760676
172DAPK20.19680082
173MAP3K130.18641682
174GRK10.18366338
175MAPKAPK50.17870510
176LATS20.17652782
177PRKCZ0.17532222
178CAMK2B0.17420778
179AURKB0.16854777
180BMPR20.16225816
181CDK30.15808636

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.70843642
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.46294451
3Complement and coagulation cascades_Homo sapiens_hsa046103.16627048
4Vitamin B6 metabolism_Homo sapiens_hsa007502.92610193
5Basal transcription factors_Homo sapiens_hsa030222.76760205
6Oxidative phosphorylation_Homo sapiens_hsa001902.60408319
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.52403987
8Huntingtons disease_Homo sapiens_hsa050162.42130222
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.33723037
10Collecting duct acid secretion_Homo sapiens_hsa049662.27441219
11Arginine biosynthesis_Homo sapiens_hsa002202.23814486
12Amphetamine addiction_Homo sapiens_hsa050312.22210834
13Fatty acid biosynthesis_Homo sapiens_hsa000612.22200702
14Cardiac muscle contraction_Homo sapiens_hsa042602.09462045
15Homologous recombination_Homo sapiens_hsa034402.09290621
16DNA replication_Homo sapiens_hsa030302.07707369
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.06990029
18Linoleic acid metabolism_Homo sapiens_hsa005912.05449186
19Oocyte meiosis_Homo sapiens_hsa041142.04889340
20Proteasome_Homo sapiens_hsa030502.03853843
21Nicotine addiction_Homo sapiens_hsa050332.02218643
22Pyruvate metabolism_Homo sapiens_hsa006201.98331148
23Parkinsons disease_Homo sapiens_hsa050121.97384425
24Pyrimidine metabolism_Homo sapiens_hsa002401.86245300
25Alzheimers disease_Homo sapiens_hsa050101.85384446
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82903501
27Long-term potentiation_Homo sapiens_hsa047201.79660156
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78756135
29RNA transport_Homo sapiens_hsa030131.73296662
30Biosynthesis of amino acids_Homo sapiens_hsa012301.73184605
31Fanconi anemia pathway_Homo sapiens_hsa034601.72294493
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71766075
33RNA polymerase_Homo sapiens_hsa030201.63535460
34Mismatch repair_Homo sapiens_hsa034301.59525528
35Glucagon signaling pathway_Homo sapiens_hsa049221.58446759
36Ribosome_Homo sapiens_hsa030101.54651955
37Purine metabolism_Homo sapiens_hsa002301.51661531
38Bladder cancer_Homo sapiens_hsa052191.51400867
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49601903
40PPAR signaling pathway_Homo sapiens_hsa033201.49519694
41Synaptic vesicle cycle_Homo sapiens_hsa047211.49277492
42Acute myeloid leukemia_Homo sapiens_hsa052211.47637462
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46152851
44Taste transduction_Homo sapiens_hsa047421.45064434
45Phenylalanine metabolism_Homo sapiens_hsa003601.42398659
46Chronic myeloid leukemia_Homo sapiens_hsa052201.41565258
47Fatty acid degradation_Homo sapiens_hsa000711.40661091
48Renin secretion_Homo sapiens_hsa049241.38766896
49Non-small cell lung cancer_Homo sapiens_hsa052231.37452848
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.35337144
51Sulfur relay system_Homo sapiens_hsa041221.33754590
52Prion diseases_Homo sapiens_hsa050201.32795247
53Insulin resistance_Homo sapiens_hsa049311.26601611
54Lysine degradation_Homo sapiens_hsa003101.24951919
55Insulin secretion_Homo sapiens_hsa049111.24017056
56Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22617021
57Central carbon metabolism in cancer_Homo sapiens_hsa052301.21409451
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20781124
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19999706
60Insulin signaling pathway_Homo sapiens_hsa049101.17068084
61Olfactory transduction_Homo sapiens_hsa047401.16570204
62Dopaminergic synapse_Homo sapiens_hsa047281.16114795
63Galactose metabolism_Homo sapiens_hsa000521.14821806
64Glycerophospholipid metabolism_Homo sapiens_hsa005641.14468370
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13150394
66Nucleotide excision repair_Homo sapiens_hsa034201.10666323
67Staphylococcus aureus infection_Homo sapiens_hsa051501.09184784
68Bile secretion_Homo sapiens_hsa049761.07842165
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07400142
70VEGF signaling pathway_Homo sapiens_hsa043701.05919509
71Pancreatic cancer_Homo sapiens_hsa052121.05223021
72Circadian entrainment_Homo sapiens_hsa047131.04184092
73Lysosome_Homo sapiens_hsa041421.03675637
74Base excision repair_Homo sapiens_hsa034101.02644695
75ABC transporters_Homo sapiens_hsa020101.02114461
76Propanoate metabolism_Homo sapiens_hsa006401.00735566
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.99780661
78Calcium signaling pathway_Homo sapiens_hsa040200.99525631
79Salivary secretion_Homo sapiens_hsa049700.98384574
80Tyrosine metabolism_Homo sapiens_hsa003500.98285083
81Vibrio cholerae infection_Homo sapiens_hsa051100.97335382
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96264630
83Fructose and mannose metabolism_Homo sapiens_hsa000510.95819942
84Alcoholism_Homo sapiens_hsa050340.94828363
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94688946
86Fatty acid metabolism_Homo sapiens_hsa012120.94590083
87Mineral absorption_Homo sapiens_hsa049780.93336723
88Pentose phosphate pathway_Homo sapiens_hsa000300.92548218
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92343376
90Vitamin digestion and absorption_Homo sapiens_hsa049770.91579098
91Spliceosome_Homo sapiens_hsa030400.90845901
92mRNA surveillance pathway_Homo sapiens_hsa030150.89726527
93mTOR signaling pathway_Homo sapiens_hsa041500.89416569
94Notch signaling pathway_Homo sapiens_hsa043300.87150674
95AMPK signaling pathway_Homo sapiens_hsa041520.86723740
96Starch and sucrose metabolism_Homo sapiens_hsa005000.86228360
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85683581
98Ether lipid metabolism_Homo sapiens_hsa005650.84243920
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83937601
100RNA degradation_Homo sapiens_hsa030180.83644562
101Glutamatergic synapse_Homo sapiens_hsa047240.83414386
102B cell receptor signaling pathway_Homo sapiens_hsa046620.82798292
103Phototransduction_Homo sapiens_hsa047440.82446939
104Systemic lupus erythematosus_Homo sapiens_hsa053220.82189648
105Glycerolipid metabolism_Homo sapiens_hsa005610.80403116
106Fat digestion and absorption_Homo sapiens_hsa049750.80250262
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79742422
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78347690
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76937607
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75434328
111Arginine and proline metabolism_Homo sapiens_hsa003300.75257074
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75212884
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75164662
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75094421
115Gastric acid secretion_Homo sapiens_hsa049710.74419509
116Histidine metabolism_Homo sapiens_hsa003400.73797442
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73621264
118Cell cycle_Homo sapiens_hsa041100.73400174
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71703803
120Arachidonic acid metabolism_Homo sapiens_hsa005900.71658719
121Endometrial cancer_Homo sapiens_hsa052130.71047590
122Glutathione metabolism_Homo sapiens_hsa004800.70170251
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.69755164
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69548075
125Small cell lung cancer_Homo sapiens_hsa052220.68918999
126Renin-angiotensin system_Homo sapiens_hsa046140.68385993
127Pertussis_Homo sapiens_hsa051330.67807607
128N-Glycan biosynthesis_Homo sapiens_hsa005100.67651266
129Carbon metabolism_Homo sapiens_hsa012000.67578904
130Dilated cardiomyopathy_Homo sapiens_hsa054140.67127944
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66426157
132Dorso-ventral axis formation_Homo sapiens_hsa043200.65958647
133TNF signaling pathway_Homo sapiens_hsa046680.65218610
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64101398
135Hepatitis C_Homo sapiens_hsa051600.63876298
136Oxytocin signaling pathway_Homo sapiens_hsa049210.63787731
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63603894
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.62268832
139Estrogen signaling pathway_Homo sapiens_hsa049150.62161108
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60751355
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.59712165
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.58161109
143Glioma_Homo sapiens_hsa052140.58104876
144Morphine addiction_Homo sapiens_hsa050320.57855052
145Sulfur metabolism_Homo sapiens_hsa009200.57004560
146Focal adhesion_Homo sapiens_hsa045100.56886467
147Amoebiasis_Homo sapiens_hsa051460.56684422
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56025853
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55540111
150Osteoclast differentiation_Homo sapiens_hsa043800.55387209
151Metabolic pathways_Homo sapiens_hsa011000.54728145
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.53246385
153Proteoglycans in cancer_Homo sapiens_hsa052050.52623735
154GnRH signaling pathway_Homo sapiens_hsa049120.52613052
155Apoptosis_Homo sapiens_hsa042100.52545768
156GABAergic synapse_Homo sapiens_hsa047270.52250777
157Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51945635
158Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51574587
159Thyroid cancer_Homo sapiens_hsa052160.51409659
160Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51241263
161Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50590558
162SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50514928
163Protein export_Homo sapiens_hsa030600.50036311
164Pancreatic secretion_Homo sapiens_hsa049720.49963088
165Non-homologous end-joining_Homo sapiens_hsa034500.49904282
166Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49704643
167Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49612701
168ECM-receptor interaction_Homo sapiens_hsa045120.48286130
169Thyroid hormone synthesis_Homo sapiens_hsa049180.47579521
170Drug metabolism - other enzymes_Homo sapiens_hsa009830.47119625
171Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47105951
172RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46556811
173Hepatitis B_Homo sapiens_hsa051610.44910647
174Serotonergic synapse_Homo sapiens_hsa047260.44567837
175Hedgehog signaling pathway_Homo sapiens_hsa043400.43999178
176Choline metabolism in cancer_Homo sapiens_hsa052310.42648365
177Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42237648
178Sphingolipid metabolism_Homo sapiens_hsa006000.42042078
179HIF-1 signaling pathway_Homo sapiens_hsa040660.41835356
180Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41543607
181cAMP signaling pathway_Homo sapiens_hsa040240.41388157
182Prostate cancer_Homo sapiens_hsa052150.40779872
183ErbB signaling pathway_Homo sapiens_hsa040120.40015172
184Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38544221
185Long-term depression_Homo sapiens_hsa047300.38301275
186Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37705633

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »