SPATA2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.54454201
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.54454201
3NIK/NF-kappaB signaling (GO:0038061)5.41485584
4GDP-mannose metabolic process (GO:0019673)5.28993974
5L-phenylalanine metabolic process (GO:0006558)5.27268974
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.27268974
7regulation of interferon-beta biosynthetic process (GO:0045357)5.16117267
8aromatic amino acid family catabolic process (GO:0009074)4.81466522
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.56632631
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.53083628
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.53083628
12modulation by symbiont of host immune response (GO:0052553)4.53083628
13positive regulation by symbiont of host defense response (GO:0052509)4.53083628
14modulation by symbiont of host defense response (GO:0052031)4.53083628
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.53083628
16bile acid biosynthetic process (GO:0006699)4.43861114
17kynurenine metabolic process (GO:0070189)4.31624838
18indole-containing compound catabolic process (GO:0042436)4.24243622
19indolalkylamine catabolic process (GO:0046218)4.24243622
20tryptophan catabolic process (GO:0006569)4.24243622
21macrophage activation involved in immune response (GO:0002281)4.18138907
22negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.13542730
23urea metabolic process (GO:0019627)4.04637080
24urea cycle (GO:0000050)4.04637080
25mannose metabolic process (GO:0006013)4.04537057
26response to peptidoglycan (GO:0032494)4.02024285
27amyloid precursor protein catabolic process (GO:0042987)4.01420642
28alpha-linolenic acid metabolic process (GO:0036109)3.97302469
29high-density lipoprotein particle remodeling (GO:0034375)3.97268932
30tryptophan metabolic process (GO:0006568)3.91742970
31dicarboxylic acid biosynthetic process (GO:0043650)3.78731753
32glutamate metabolic process (GO:0006536)3.77051845
33negative regulation of fibrinolysis (GO:0051918)3.76991349
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.76381571
35glyoxylate metabolic process (GO:0046487)3.72654358
36bile acid metabolic process (GO:0008206)3.71925429
37nitrogen cycle metabolic process (GO:0071941)3.71687327
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.71085047
39regulation of fibrinolysis (GO:0051917)3.69319884
40protein retention in ER lumen (GO:0006621)3.67662231
41cysteine metabolic process (GO:0006534)3.66883067
42regulation of short-term neuronal synaptic plasticity (GO:0048172)3.66013625
43negative regulation of erythrocyte differentiation (GO:0045647)3.64632459
44regulation of protein activation cascade (GO:2000257)3.58118198
45sulfur amino acid catabolic process (GO:0000098)3.55041108
46complement activation, alternative pathway (GO:0006957)3.53766175
47cellular ketone body metabolic process (GO:0046950)3.52348862
48locomotory exploration behavior (GO:0035641)3.50482570
49protein carboxylation (GO:0018214)3.49175906
50peptidyl-glutamic acid carboxylation (GO:0017187)3.49175906
51neurotransmitter-gated ion channel clustering (GO:0072578)3.46053136
52protein insertion into membrane (GO:0051205)3.44494408
53reverse cholesterol transport (GO:0043691)3.41535991
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.40590931
55aromatic amino acid family metabolic process (GO:0009072)3.40552579
56vocalization behavior (GO:0071625)3.38644945
57maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.37434723
58regulation of cholesterol esterification (GO:0010872)3.36229796
59synaptic vesicle maturation (GO:0016188)3.32785110
60plasma lipoprotein particle remodeling (GO:0034369)3.32448923
61protein-lipid complex remodeling (GO:0034368)3.32448923
62macromolecular complex remodeling (GO:0034367)3.32448923
63glutamate secretion (GO:0014047)3.31845004
64regulation of complement activation (GO:0030449)3.31829827
65serine family amino acid catabolic process (GO:0009071)3.30967545
66alpha-amino acid catabolic process (GO:1901606)3.28827139
67negative regulation of cholesterol transport (GO:0032375)3.27422373
68negative regulation of sterol transport (GO:0032372)3.27422373
69adenosine receptor signaling pathway (GO:0001973)3.26873738
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.25842379
71regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.25076579
72positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.23687005
73lysine metabolic process (GO:0006553)3.23621617
74lysine catabolic process (GO:0006554)3.23621617
75tyrosine metabolic process (GO:0006570)3.23348815
76cellular modified amino acid catabolic process (GO:0042219)3.22625669
77coenzyme catabolic process (GO:0009109)3.22238392
78regulation of chemokine biosynthetic process (GO:0045073)3.21593210
79synaptic vesicle exocytosis (GO:0016079)3.21426720
80regulation of long-term neuronal synaptic plasticity (GO:0048169)3.20127453
81regulation of glutamate receptor signaling pathway (GO:1900449)3.16178558
82positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.13952048
83regulation of triglyceride catabolic process (GO:0010896)3.13328769
84positive regulation of Cdc42 GTPase activity (GO:0043089)3.13090586
85glycosphingolipid catabolic process (GO:0046479)3.12641478
86regulation of mammary gland epithelial cell proliferation (GO:0033599)3.11272032
87acylglycerol homeostasis (GO:0055090)3.10936051
88triglyceride homeostasis (GO:0070328)3.10936051
89proline biosynthetic process (GO:0006561)3.10085377
90regulation of neuronal synaptic plasticity (GO:0048168)3.09984680
91negative regulation of DNA-templated transcription, elongation (GO:0032785)3.08436802
92gamma-aminobutyric acid transport (GO:0015812)3.08405000
93negative regulation of viral release from host cell (GO:1902187)3.07839631
94cellular amino acid catabolic process (GO:0009063)3.06389334
95homocysteine metabolic process (GO:0050667)3.05985436
96sterol catabolic process (GO:0016127)3.03810687
97cholesterol catabolic process (GO:0006707)3.03810687
98ketone body metabolic process (GO:1902224)3.02827262
99phospholipid efflux (GO:0033700)3.02241798
100ionotropic glutamate receptor signaling pathway (GO:0035235)3.00171160
101indole-containing compound metabolic process (GO:0042430)2.99990451
102membrane protein intracellular domain proteolysis (GO:0031293)2.99518533
103lipopolysaccharide-mediated signaling pathway (GO:0031663)2.98176997
104neurotransmitter secretion (GO:0007269)2.96879058
105positive regulation of chemokine biosynthetic process (GO:0045080)2.96571573
106pentose metabolic process (GO:0019321)2.95956860
107drug catabolic process (GO:0042737)2.95931522
108amino-acid betaine metabolic process (GO:0006577)2.95401322
109negative regulation of myeloid cell apoptotic process (GO:0033033)2.93739684
110cholesterol efflux (GO:0033344)2.93364737
111indolalkylamine metabolic process (GO:0006586)2.92006462
112cell-cell junction maintenance (GO:0045217)2.91791517
113regulation of synapse structural plasticity (GO:0051823)2.86302014
114short-chain fatty acid metabolic process (GO:0046459)2.86023467
115dicarboxylic acid catabolic process (GO:0043649)2.85993462
116behavioral response to cocaine (GO:0048148)2.85652640
117peptidyl-arginine omega-N-methylation (GO:0035247)2.85186051
118protein localization to synapse (GO:0035418)2.84691472
119negative regulation of lipase activity (GO:0060192)2.83944711
120synaptic vesicle docking involved in exocytosis (GO:0016081)2.83915024
121bile acid and bile salt transport (GO:0015721)2.83548640
122glycolipid catabolic process (GO:0019377)2.83197057
123amyloid precursor protein metabolic process (GO:0042982)2.81348467
124plasma lipoprotein particle clearance (GO:0034381)2.81067603
125imidazole-containing compound metabolic process (GO:0052803)2.79819305
126cellular response to virus (GO:0098586)2.79665732
127regulation of type I interferon-mediated signaling pathway (GO:0060338)2.79362767
128low-density lipoprotein particle remodeling (GO:0034374)2.79223917
129cytolysis (GO:0019835)2.79198381
130benzene-containing compound metabolic process (GO:0042537)2.78723718
131aspartate family amino acid catabolic process (GO:0009068)2.78441477
132amine catabolic process (GO:0009310)2.76861700
133cellular biogenic amine catabolic process (GO:0042402)2.76861700
134exploration behavior (GO:0035640)2.74909274
135response to host immune response (GO:0052572)2.74084108
136response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.74084108
137modulation by symbiont of host cellular process (GO:0044068)2.73919547
138negative regulation of tumor necrosis factor production (GO:0032720)2.73708515
139response to muramyl dipeptide (GO:0032495)2.73634184
140regulation of bile acid biosynthetic process (GO:0070857)2.73218288
141positive regulation of lipid catabolic process (GO:0050996)2.72428614
142regulation of synaptic vesicle exocytosis (GO:2000300)2.72313865
143regulation of cholesterol homeostasis (GO:2000188)2.70787833
144exogenous drug catabolic process (GO:0042738)2.70403578
145regulation of T-helper 2 cell differentiation (GO:0045628)2.70340687
146regulation of interferon-gamma biosynthetic process (GO:0045072)2.70048050
147negative regulation of protein activation cascade (GO:2000258)2.69234935
148positive regulation of interferon-alpha production (GO:0032727)2.67183807
149modulation by virus of host process (GO:0019054)2.66905023
150virion assembly (GO:0019068)2.66365498
151activation of Rac GTPase activity (GO:0032863)2.65890940
152macrophage activation (GO:0042116)2.64441035
153intracellular estrogen receptor signaling pathway (GO:0030520)2.63794977
154negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.63571421
155apoptotic process involved in morphogenesis (GO:0060561)2.62346421
156regulation of interferon-alpha production (GO:0032647)2.62076189
157activation of MAPKKK activity (GO:0000185)2.60630985
158protein localization to endosome (GO:0036010)2.59247113
159amino sugar catabolic process (GO:0046348)2.57162909
160negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.56708876
161negative regulation of interleukin-2 production (GO:0032703)2.56639281
162pyrimidine nucleoside salvage (GO:0043097)2.55923316
163pyrimidine-containing compound salvage (GO:0008655)2.55923316
164regulation of chromatin binding (GO:0035561)2.53410740
165response to host (GO:0075136)2.53052803
166response to host defenses (GO:0052200)2.53052803
167response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.53052803
168negative regulation of interleukin-8 production (GO:0032717)2.52804301
169negative regulation of toll-like receptor signaling pathway (GO:0034122)2.52312556
170Golgi transport vesicle coating (GO:0048200)2.52154046
171COPI coating of Golgi vesicle (GO:0048205)2.52154046
172germinal center formation (GO:0002467)2.50707243
173positive regulation of interferon-beta production (GO:0032728)2.49838955
174positive regulation of transcription factor import into nucleus (GO:0042993)2.47585077
175negative regulation of cell size (GO:0045792)2.46750144
176peptidyl-arginine N-methylation (GO:0035246)2.46398393
177peptidyl-arginine methylation (GO:0018216)2.46398393
178purinergic receptor signaling pathway (GO:0035587)2.45662717
179retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.45402205
180glucose 6-phosphate metabolic process (GO:0051156)2.44693177
181chaperone mediated protein folding requiring cofactor (GO:0051085)2.43258375
182pentose-phosphate shunt (GO:0006098)2.42625170
183purinergic nucleotide receptor signaling pathway (GO:0035590)2.42440923
184tumor necrosis factor-mediated signaling pathway (GO:0033209)2.42144982
185positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.41246167
186ceramide catabolic process (GO:0046514)2.41126082
187regulation of viral release from host cell (GO:1902186)2.40403490
188UV protection (GO:0009650)2.40318215
189viral protein processing (GO:0019082)2.40304831
190respiratory burst (GO:0045730)2.39208276
191epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38320067
192regulation of ARF GTPase activity (GO:0032312)2.37962578
193regulation of cholesterol biosynthetic process (GO:0045540)2.37788102
194neutrophil mediated immunity (GO:0002446)2.37342514
195immunoglobulin mediated immune response (GO:0016064)2.35979218
196semaphorin-plexin signaling pathway (GO:0071526)2.35954591
197G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.35145917
198barbed-end actin filament capping (GO:0051016)2.35139786
199positive regulation of T cell apoptotic process (GO:0070234)2.34373183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.12209529
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.26890576
3EZH2_22144423_ChIP-Seq_EOC_Human4.05919398
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.42417132
5VDR_21846776_ChIP-Seq_THP-1_Human3.38457950
6* LXR_22158963_ChIP-Seq_LIVER_Mouse3.33926695
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.23291848
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.21172879
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.85488362
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.58754147
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.51580047
12MYC_22102868_ChIP-Seq_BL_Human2.44974526
13GBX2_23144817_ChIP-Seq_PC3_Human2.43936054
14* RARB_27405468_Chip-Seq_BRAIN_Mouse2.41485361
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31500475
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.23979075
17* ELK3_25401928_ChIP-Seq_HUVEC_Human2.23377522
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18473858
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17724563
20RACK7_27058665_Chip-Seq_MCF-7_Human2.17257275
21REST_21632747_ChIP-Seq_MESCs_Mouse2.15531384
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14423159
23P68_20966046_ChIP-Seq_HELA_Human2.08304655
24DROSHA_22980978_ChIP-Seq_HELA_Human2.06858335
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05527161
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04406310
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01103386
28* KDM2B_26808549_Chip-Seq_DND41_Human1.96318949
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94807497
30* TET1_21451524_ChIP-Seq_MESCs_Mouse1.94262128
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92952348
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.88977579
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86027166
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84083330
35TCF7_22412390_ChIP-Seq_EML_Mouse1.83914581
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.83586602
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.80383404
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79094479
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79094479
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74659415
41VDR_24763502_ChIP-Seq_THP-1_Human1.72721557
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72089762
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70668460
44BCL6_27268052_Chip-Seq_Bcells_Human1.69997163
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68311898
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.68173185
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67707987
48BCOR_27268052_Chip-Seq_Bcells_Human1.67577891
49MAF_26560356_Chip-Seq_TH2_Human1.67147231
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.66452394
51* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.65747159
52MAF_26560356_Chip-Seq_TH1_Human1.65667548
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65482251
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65150469
55ZNF263_19887448_ChIP-Seq_K562_Human1.63999095
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63958214
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.63135769
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.62211732
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61319686
60* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57228650
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56607225
62TAF15_26573619_Chip-Seq_HEK293_Human1.52069957
63SMC4_20622854_ChIP-Seq_HELA_Human1.50919002
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45442648
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43480348
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42762029
67UTX_26944678_Chip-Seq_JUKART_Human1.42690716
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.42602059
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40938404
70* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40350802
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39284573
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38479605
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37799571
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36303612
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36183984
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35938733
77* CREB1_26743006_Chip-Seq_LNCaP_Human1.35929626
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35569011
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35229184
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.34943328
81* XRN2_22483619_ChIP-Seq_HELA_Human1.34394079
82PHF8_20622854_ChIP-Seq_HELA_Human1.34299430
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33220171
84RARB_24833708_ChIP-Seq_LIVER_Mouse1.32117000
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.31842602
86AR_21572438_ChIP-Seq_LNCaP_Human1.31826470
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31400629
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.31288665
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30255938
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30122260
91RARA_24833708_ChIP-Seq_LIVER_Mouse1.29877403
92E2F1_20622854_ChIP-Seq_HELA_Human1.28467701
93CTCF_21964334_Chip-Seq_Bcells_Human1.28115028
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27727860
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27675614
96TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27272764
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26493454
98TP53_22127205_ChIP-Seq_IMR90_Human1.26040597
99NCOR1_26117541_ChIP-Seq_K562_Human1.23873093
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23785330
101MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23518327
102* ATF3_27146783_Chip-Seq_COLON_Human1.22318843
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22122213
104CTCF_26484167_Chip-Seq_Bcells_Mouse1.21835720
105* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21464868
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20981808
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20638565
108CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19987243
109RUNX1_22412390_ChIP-Seq_EML_Mouse1.19519234
110* KDM2B_26808549_Chip-Seq_JURKAT_Human1.19501836
111FOXA2_19822575_ChIP-Seq_HepG2_Human1.18297623
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17259920
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15977113
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15961097
115CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15836402
116BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15391857
117* FOXP1_21924763_ChIP-Seq_HESCs_Human1.14939128
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14396969
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14095719
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13374834
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13354522
122SMAD4_21799915_ChIP-Seq_A2780_Human1.11002524
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08768593
124ETS1_21867929_ChIP-Seq_TH2_Mouse1.08639249
125CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08630231
126GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07897260
127IRF8_22096565_ChIP-ChIP_GC-B_Human1.07201987
128JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06183707
129GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05895608
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05166501
131SA1_27219007_Chip-Seq_Bcells_Human1.05066303
132RUNX1_27514584_Chip-Seq_MCF-7_Human1.04803075
133TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03413382
134SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03210981
135NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03140707
136YY1_22570637_ChIP-Seq_MALME-3M_Human1.02917040
137RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01935373
138PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01773128
139* GATA1_19941827_ChIP-Seq_MEL_Mouse1.00597598
140HTT_18923047_ChIP-ChIP_STHdh_Human0.98809158
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98216812
142EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97611718
143CTCF_27219007_Chip-Seq_Bcells_Human0.97007002
144SOX2_21211035_ChIP-Seq_LN229_Gbm0.96539212
145LXR_22292898_ChIP-Seq_THP-1_Human0.96227384
146RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95731068
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93074726
148GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92799542
149CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92574358
150BCAT_22108803_ChIP-Seq_LS180_Human0.90922711
151AR_25329375_ChIP-Seq_VCAP_Human0.89759278
152P300_19829295_ChIP-Seq_ESCs_Human0.87994374
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86662165
154AR_19668381_ChIP-Seq_PC3_Human0.86537760
155TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84519933
156* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84134680
157PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82634660
158RING1B_27294783_Chip-Seq_ESCs_Mouse0.82580859
159RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81252237
160SMAD3_21741376_ChIP-Seq_EPCs_Human0.80748392
161TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80726820
162ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79195133
163STAT3_23295773_ChIP-Seq_U87_Human0.78981581
164SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78506661
165BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.77924750
166ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77768797
167PIAS1_25552417_ChIP-Seq_VCAP_Human0.76587439
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.75725420
169SMAD4_21741376_ChIP-Seq_EPCs_Human0.75111926
170HNF4A_19822575_ChIP-Seq_HepG2_Human0.75013927
171ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74692379
172* KDM2B_26808549_Chip-Seq_K562_Human0.73544298
173SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73211648
174AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.72756134
175ZNF274_21170338_ChIP-Seq_K562_Hela0.72493290
176GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72049627
177NR3C1_21868756_ChIP-Seq_MCF10A_Human0.71345029
178KLF4_19829295_ChIP-Seq_ESCs_Human0.71072241
179RXR_22108803_ChIP-Seq_LS180_Human0.70150105
180MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.68950382
181ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68439705
182TCF4_23295773_ChIP-Seq_U87_Human0.68250882
183MYC_27129775_Chip-Seq_CORNEA_Mouse0.67446390
184TET1_21490601_ChIP-Seq_MESCs_Mouse0.67090136
185VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.66194793
186PRDM14_20953172_ChIP-Seq_ESCs_Human0.66160743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.41342175
2MP0005360_urolithiasis5.16252535
3MP0004859_abnormal_synaptic_plasticity4.74459061
4MP0005085_abnormal_gallbladder_physiolo4.68287867
5MP0005365_abnormal_bile_salt4.33163918
6MP0005058_abnormal_lysosome_morphology4.31346507
7MP0002822_catalepsy4.26797321
8MP0003303_peritoneal_inflammation3.92129718
9MP0008875_abnormal_xenobiotic_pharmacok3.55524122
10MP0003436_decreased_susceptibility_to3.41122027
11MP0008260_abnormal_autophagy2.95123174
12MP0003880_abnormal_central_pattern2.94010472
13MP0005451_abnormal_body_composition2.93856393
14MP0003635_abnormal_synaptic_transmissio2.86067358
15MP0003172_abnormal_lysosome_physiology2.78669678
16MP0010329_abnormal_lipoprotein_level2.68488286
17MP0003252_abnormal_bile_duct2.67078609
18MP0009745_abnormal_behavioral_response2.49506305
19MP0005076_abnormal_cell_differentiation2.42450975
20MP0002063_abnormal_learning/memory/cond2.37459185
21MP0009278_abnormal_bone_marrow2.36589267
22MP0002254_reproductive_system_inflammat2.35103536
23MP0004270_analgesia2.34133089
24MP0003705_abnormal_hypodermis_morpholog2.21366987
25MP0003453_abnormal_keratinocyte_physiol2.19338128
26MP0005083_abnormal_biliary_tract2.15126815
27MP0003329_amyloid_beta_deposits2.10845629
28MP0002064_seizures2.09591559
29MP0009840_abnormal_foam_cell1.99298837
30MP0005332_abnormal_amino_acid1.97237315
31MP0003195_calcinosis1.96391831
32MP0001666_abnormal_nutrient_absorption1.92410312
33MP0002572_abnormal_emotion/affect_behav1.91251188
34MP0003806_abnormal_nucleotide_metabolis1.87028734
35MP0001968_abnormal_touch/_nociception1.82679975
36MP0005025_abnormal_response_to1.82178148
37MP0001873_stomach_inflammation1.81933661
38MP0002419_abnormal_innate_immunity1.79436073
39MP0009333_abnormal_splenocyte_physiolog1.76158716
40MP0004947_skin_inflammation1.73836238
41MP0005000_abnormal_immune_tolerance1.71218318
42MP0001849_ear_inflammation1.64580232
43MP0001501_abnormal_sleep_pattern1.63903830
44MP0009046_muscle_twitch1.63781017
45MP0002148_abnormal_hypersensitivity_rea1.63729619
46MP0002118_abnormal_lipid_homeostasis1.62646225
47MP0000604_amyloidosis1.62520118
48MP0001348_abnormal_lacrimal_gland1.62314189
49MP0003724_increased_susceptibility_to1.57779579
50MP0002272_abnormal_nervous_system1.57042205
51MP0002723_abnormal_immune_serum1.56792619
52MP0005387_immune_system_phenotype1.54907887
53MP0001790_abnormal_immune_system1.54907887
54MP0000678_abnormal_parathyroid_gland1.54133840
55MP0000750_abnormal_muscle_regeneration1.52220370
56MP0002909_abnormal_adrenal_gland1.51889474
57MP0002452_abnormal_antigen_presenting1.50636574
58MP0002736_abnormal_nociception_after1.49163087
59MP0001486_abnormal_startle_reflex1.49138449
60MP0005409_darkened_coat_color1.49061677
61MP0000858_altered_metastatic_potential1.47714634
62MP0005501_abnormal_skin_physiology1.47181885
63MP0001800_abnormal_humoral_immune1.46483215
64MP0006082_CNS_inflammation1.43232635
65MP0003191_abnormal_cellular_cholesterol1.40833950
66MP0003868_abnormal_feces_composition1.37574201
67MP0005584_abnormal_enzyme/coenzyme_acti1.37014990
68MP0002138_abnormal_hepatobiliary_system1.36865117
69MP0001819_abnormal_immune_cell1.36860551
70MP0001835_abnormal_antigen_presentation1.35955859
71MP0002420_abnormal_adaptive_immunity1.35937120
72MP0003075_altered_response_to1.33895026
73MP0001533_abnormal_skeleton_physiology1.32228356
74MP0008874_decreased_physiological_sensi1.29681972
75MP0005535_abnormal_body_temperature1.28911244
76MP0002249_abnormal_larynx_morphology1.28452941
77MP0001986_abnormal_taste_sensitivity1.28276667
78MP0001440_abnormal_grooming_behavior1.26609398
79MP0005423_abnormal_somatic_nervous1.26494060
80MP0005310_abnormal_salivary_gland1.25901829
81MP0003879_abnormal_hair_cell1.25356156
82MP0000609_abnormal_liver_physiology1.25118465
83MP0004019_abnormal_vitamin_homeostasis1.24864289
84MP0005646_abnormal_pituitary_gland1.24301340
85MP0009785_altered_susceptibility_to1.24094091
86MP0002735_abnormal_chemical_nociception1.23858434
87MP0000015_abnormal_ear_pigmentation1.22518030
88MP0002734_abnormal_mechanical_nocicepti1.22466568
89MP0009780_abnormal_chondrocyte_physiolo1.22001496
90MP0002796_impaired_skin_barrier1.21783338
91MP0010155_abnormal_intestine_physiology1.20421425
92MP0003633_abnormal_nervous_system1.20220055
93MP0002733_abnormal_thermal_nociception1.19283464
94MP0000685_abnormal_immune_system1.18690144
95MP0008872_abnormal_physiological_respon1.18589478
96MP0005319_abnormal_enzyme/_coenzyme1.14542108
97MP0010234_abnormal_vibrissa_follicle1.13909186
98MP0001845_abnormal_inflammatory_respons1.13803341
99MP0004381_abnormal_hair_follicle1.13239935
100MP0004264_abnormal_extraembryonic_tissu1.12308186
101MP0001984_abnormal_olfaction1.11837908
102MP0002405_respiratory_system_inflammati1.08922144
103MP0003300_gastrointestinal_ulcer1.08900176
104MP0002837_dystrophic_cardiac_calcinosis1.08523114
105MP0004924_abnormal_behavior1.07673740
106MP0005386_behavior/neurological_phenoty1.07673740
107MP0002876_abnormal_thyroid_physiology1.07580965
108MP0003123_paternal_imprinting1.07430368
109MP0003183_abnormal_peptide_metabolism1.07293007
110MP0008469_abnormal_protein_level1.06061762
111MP0003690_abnormal_glial_cell1.05833069
112MP0000716_abnormal_immune_system1.04622796
113MP0001970_abnormal_pain_threshold1.03495193
114MP0005257_abnormal_intraocular_pressure0.97961680
115MP0002067_abnormal_sensory_capabilities0.97733258
116MP0002429_abnormal_blood_cell0.97199158
117MP0002557_abnormal_social/conspecific_i0.97031590
118MP0009931_abnormal_skin_appearance0.96434190
119MP0002998_abnormal_bone_remodeling0.96322782
120MP0001529_abnormal_vocalization0.95298609
121MP0001764_abnormal_homeostasis0.94924231
122MP0003448_altered_tumor_morphology0.94352761
123MP0002398_abnormal_bone_marrow0.94293507
124MP0009764_decreased_sensitivity_to0.93693354
125MP0004811_abnormal_neuron_physiology0.92019833
126MP0008569_lethality_at_weaning0.91830980
127MP0000538_abnormal_urinary_bladder0.91620315
128MP0001727_abnormal_embryo_implantation0.91322802
129MP0003631_nervous_system_phenotype0.89937726
130MP0000003_abnormal_adipose_tissue0.89469448
131MP0004185_abnormal_adipocyte_glucose0.89400538
132MP0000490_abnormal_crypts_of0.89170732
133MP0003221_abnormal_cardiomyocyte_apopto0.88892549
134MP0004233_abnormal_muscle_weight0.87178961
135MP0004130_abnormal_muscle_cell0.85975701
136MP0005671_abnormal_response_to0.85539218
137MP0005397_hematopoietic_system_phenotyp0.85204165
138MP0001545_abnormal_hematopoietic_system0.85204165
139MP0002078_abnormal_glucose_homeostasis0.84499981
140MP0002069_abnormal_eating/drinking_beha0.83729969
141MP0002098_abnormal_vibrissa_morphology0.83680473
142MP0002066_abnormal_motor_capabilities/c0.83509321
143MP0005084_abnormal_gallbladder_morpholo0.83154026
144MP0001502_abnormal_circadian_rhythm0.82822569
145MP0005375_adipose_tissue_phenotype0.82390540
146MP0001188_hyperpigmentation0.82155808
147MP0003091_abnormal_cell_migration0.82067726
148MP0002877_abnormal_melanocyte_morpholog0.81912792
149MP0000343_altered_response_to0.81323011
150MP0002653_abnormal_ependyma_morphology0.81099330
151MP0002332_abnormal_exercise_endurance0.80429259
152MP0008961_abnormal_basal_metabolism0.78950366
153MP0000689_abnormal_spleen_morphology0.77747786
154MP0005174_abnormal_tail_pigmentation0.77649245
155MP0002722_abnormal_immune_system0.76698641
156MP0005166_decreased_susceptibility_to0.75973452
157MP0005448_abnormal_energy_balance0.75930373
158MP0004858_abnormal_nervous_system0.75368532
159MP0001216_abnormal_epidermal_layer0.74346458
160MP0005167_abnormal_blood-brain_barrier0.73007526
161MP0005464_abnormal_platelet_physiology0.72824369
162MP0005390_skeleton_phenotype0.72168859
163MP0002089_abnormal_postnatal_growth/wei0.72094723
164MP0001905_abnormal_dopamine_level0.71733586
165MP0002184_abnormal_innervation0.71554070
166MP0006276_abnormal_autonomic_nervous0.71472869
167MP0001765_abnormal_ion_homeostasis0.70384519
168MP0005636_abnormal_mineral_homeostasis0.70240847
169MP0002090_abnormal_vision0.69555364
170MP0004142_abnormal_muscle_tone0.67724117
171MP0000955_abnormal_spinal_cord0.66410641
172MP0009642_abnormal_blood_homeostasis0.64985925
173MP0009643_abnormal_urine_homeostasis0.63624160
174MP0004885_abnormal_endolymph0.63358222
175MP0003656_abnormal_erythrocyte_physiolo0.62616087
176MP0004510_myositis0.61169547
177MP0000639_abnormal_adrenal_gland0.61094370
178MP0003953_abnormal_hormone_level0.60702767
179MP0000013_abnormal_adipose_tissue0.60163002
180MP0005334_abnormal_fat_pad0.57315900
181MP0006035_abnormal_mitochondrial_morpho0.55510216
182MP0003638_abnormal_response/metabolism_0.54174982
183MP0002882_abnormal_neuron_morphology0.53610787
184MP0002229_neurodegeneration0.53608206
185MP0005187_abnormal_penis_morphology0.53377925

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.80138272
2Deep venous thrombosis (HP:0002625)5.57265943
3Intrahepatic cholestasis (HP:0001406)4.84749651
4Myokymia (HP:0002411)4.82540057
5Focal motor seizures (HP:0011153)4.76551275
6Prolonged partial thromboplastin time (HP:0003645)4.70088355
7Hypobetalipoproteinemia (HP:0003563)4.68763466
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.58225343
9Xanthomatosis (HP:0000991)4.55143459
10Hyperlipoproteinemia (HP:0010980)4.27148190
11Complement deficiency (HP:0004431)3.96588638
12Thin bony cortex (HP:0002753)3.80209263
13Ketosis (HP:0001946)3.69736526
14Abnormality of liposaccharide metabolism (HP:0010968)3.65494682
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.65494682
16Abnormality of glycolipid metabolism (HP:0010969)3.65494682
17Hyperventilation (HP:0002883)3.57458066
18Eczematoid dermatitis (HP:0000976)3.56094509
19Increased cerebral lipofuscin (HP:0011813)3.47757575
20Testicular atrophy (HP:0000029)3.46989069
21Dysostosis multiplex (HP:0000943)3.45535822
22Focal seizures (HP:0007359)3.43950783
23Loss of speech (HP:0002371)3.32256482
24Hyperglycinemia (HP:0002154)3.31368336
25Hyperammonemia (HP:0001987)3.30361846
26Epidermoid cyst (HP:0200040)3.29806713
27Hypolipoproteinemia (HP:0010981)3.28446467
28Abnormality of mucopolysaccharide metabolism (HP:0011020)3.22999892
29Abnormality of polysaccharide metabolism (HP:0011012)3.22999892
30Abnormality of glycosaminoglycan metabolism (HP:0004371)3.22999892
31Joint hemorrhage (HP:0005261)3.22069889
32Visual hallucinations (HP:0002367)3.21646549
33Recurrent bacterial skin infections (HP:0005406)3.20884217
34Abnormality of the common coagulation pathway (HP:0010990)3.20406401
35Status epilepticus (HP:0002133)3.13873494
36Recurrent abscess formation (HP:0002722)3.10953176
37Hemorrhage of the eye (HP:0011885)3.10173787
38Increased neuronal autofluorescent lipopigment (HP:0002074)3.08829892
39Abnormality of macrophages (HP:0004311)2.99913478
40Urinary glycosaminoglycan excretion (HP:0003541)2.99287296
41Mucopolysacchariduria (HP:0008155)2.99287296
42Neuronal loss in central nervous system (HP:0002529)2.96338176
43Ulnar bowing (HP:0003031)2.94302418
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.92481637
45Fat malabsorption (HP:0002630)2.89511757
46Abnormality of sulfur amino acid metabolism (HP:0004339)2.88101342
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.87731557
48Spontaneous abortion (HP:0005268)2.81015592
49Ketoacidosis (HP:0001993)2.80575164
50Vacuolated lymphocytes (HP:0001922)2.79986591
51Abnormality of methionine metabolism (HP:0010901)2.79826441
52Cerebral inclusion bodies (HP:0100314)2.79068063
53Delayed CNS myelination (HP:0002188)2.78822170
54Torticollis (HP:0000473)2.76755471
55Abnormality of serine family amino acid metabolism (HP:0010894)2.76439411
56Abnormality of glycine metabolism (HP:0010895)2.76439411
57Focal dystonia (HP:0004373)2.74599913
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.73329755
59Hypoalphalipoproteinemia (HP:0003233)2.73059747
60Neurofibrillary tangles (HP:0002185)2.71678678
61Akinesia (HP:0002304)2.70224567
62Abnormal social behavior (HP:0012433)2.67422204
63Impaired social interactions (HP:0000735)2.67422204
64Abnormality of complement system (HP:0005339)2.65227384
65Craniofacial dystonia (HP:0012179)2.64660767
66Poor eye contact (HP:0000817)2.63763362
67Cellulitis (HP:0100658)2.63369845
68Hypercholesterolemia (HP:0003124)2.62119059
69Mediastinal lymphadenopathy (HP:0100721)2.61545438
70Gout (HP:0001997)2.61521201
71Generalized tonic-clonic seizures (HP:0002069)2.61406112
72Hyperglycinuria (HP:0003108)2.59325830
73Abnormality of the lower motor neuron (HP:0002366)2.59233882
74Abnormality of the intrinsic pathway (HP:0010989)2.54234279
75Obstructive lung disease (HP:0006536)2.54120310
76Chronic obstructive pulmonary disease (HP:0006510)2.54120310
77Epileptic encephalopathy (HP:0200134)2.53363082
78Conjugated hyperbilirubinemia (HP:0002908)2.52175373
79J-shaped sella turcica (HP:0002680)2.51665784
80Long palpebral fissure (HP:0000637)2.49857911
81Cholecystitis (HP:0001082)2.48514228
82Abnormal gallbladder physiology (HP:0012438)2.48514228
83Absence seizures (HP:0002121)2.46840156
84Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.46694142
85Impaired vibration sensation in the lower limbs (HP:0002166)2.45460133
86Anxiety (HP:0000739)2.44641326
87Hypertensive crisis (HP:0100735)2.42749698
88Vaginal fistula (HP:0004320)2.41007088
89Rapidly progressive (HP:0003678)2.39955243
90Annular pancreas (HP:0001734)2.39319954
91Upper limb amyotrophy (HP:0009129)2.38756777
92Distal upper limb amyotrophy (HP:0007149)2.38756777
93Neonatal onset (HP:0003623)2.38416453
94Interstitial pulmonary disease (HP:0006530)2.36326359
95Sensorimotor neuropathy (HP:0007141)2.36291812
96Progressive neurologic deterioration (HP:0002344)2.34578918
97Postural instability (HP:0002172)2.34139027
98Hyperacusis (HP:0010780)2.34004276
99Hypoglycemic coma (HP:0001325)2.32421305
100Hyperbilirubinemia (HP:0002904)2.32179440
101Skin nodule (HP:0200036)2.31338971
102Amyloidosis (HP:0011034)2.29816168
103Peripheral hypomyelination (HP:0007182)2.29258435
104Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.28465222
105Dialeptic seizures (HP:0011146)2.28174821
106Bulbar palsy (HP:0001283)2.27660438
107Increased serum ferritin (HP:0003281)2.24435465
108Action tremor (HP:0002345)2.20310824
109Ragged-red muscle fibers (HP:0003200)2.19960999
110Turricephaly (HP:0000262)2.18188571
111Atonic seizures (HP:0010819)2.17499329
112Dysmetria (HP:0001310)2.17154876
113Dysdiadochokinesis (HP:0002075)2.14972726
114Micronodular cirrhosis (HP:0001413)2.14115587
115Truncus arteriosus (HP:0001660)2.14023777
116Ankle clonus (HP:0011448)2.13922301
117Steatorrhea (HP:0002570)2.13913886
118Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.13038657
119Progressive cerebellar ataxia (HP:0002073)2.12873090
120Supranuclear gaze palsy (HP:0000605)2.12794295
121Epileptiform EEG discharges (HP:0011182)2.11841910
122Prolonged neonatal jaundice (HP:0006579)2.11512497
123Scanning speech (HP:0002168)2.10867178
124Recurrent gram-negative bacterial infections (HP:0005420)2.10581194
125Metabolic acidosis (HP:0001942)2.10261188
126Impaired vibratory sensation (HP:0002495)2.10222867
127Diminished motivation (HP:0000745)2.09918573
128Poikiloderma (HP:0001029)2.09161646
129Dementia (HP:0000726)2.08623449
130Hand muscle atrophy (HP:0009130)2.06879688
131Depression (HP:0000716)2.06253523
132Mitral stenosis (HP:0001718)2.06144018
133Stridor (HP:0010307)2.04701266
134Irritability (HP:0000737)2.02713139
135Hypochromic microcytic anemia (HP:0004840)2.02478574
136Broad distal phalanx of finger (HP:0009836)2.02134140
137Global brain atrophy (HP:0002283)2.01524246
138Abnormality of serum amino acid levels (HP:0003112)2.01345416
139EEG with generalized epileptiform discharges (HP:0011198)2.00448271
140Joint stiffness (HP:0001387)1.99876696
141Urinary bladder sphincter dysfunction (HP:0002839)1.99211541
142Abnormality of pyrimidine metabolism (HP:0004353)1.98313892
143Dysmetric saccades (HP:0000641)1.98203095
144Abnormality of the Achilles tendon (HP:0005109)1.98084121
145Febrile seizures (HP:0002373)1.97725398
146Abnormality of nucleobase metabolism (HP:0010932)1.97706760
147Abnormality of purine metabolism (HP:0004352)1.97403194
148Abnormal gallbladder morphology (HP:0012437)1.97322521
149Myositis (HP:0100614)1.96479499
150Axonal loss (HP:0003447)1.96428626
151Hypsarrhythmia (HP:0002521)1.95508679
152Cholelithiasis (HP:0001081)1.94746790
153Mesangial abnormality (HP:0001966)1.94380211
154Abnormality of fatty-acid metabolism (HP:0004359)1.94379574
155Acanthocytosis (HP:0001927)1.93926993
156Fair hair (HP:0002286)1.93521763
157Apathy (HP:0000741)1.92429163
158Abnormality of the thoracic spine (HP:0100711)1.92069323
159Abnormal trabecular bone morphology (HP:0100671)1.91323201
160Tetraplegia (HP:0002445)1.90402964
161Myopathic facies (HP:0002058)1.90016988
162Achilles tendon contracture (HP:0001771)1.89856533
163Generalized myoclonic seizures (HP:0002123)1.89361864
164Intestinal fistula (HP:0100819)1.89079156
165Distal lower limb amyotrophy (HP:0008944)1.88493451
166Nuclear cataract (HP:0100018)1.88212765
167Upper motor neuron abnormality (HP:0002127)1.87041168
168Confusion (HP:0001289)1.86928296
169Colitis (HP:0002583)1.85397001
170Orchitis (HP:0100796)1.84656200
171Malnutrition (HP:0004395)1.81957082
172Vertebral compression fractures (HP:0002953)1.79942728
173Delayed epiphyseal ossification (HP:0002663)1.78594528
174Easy fatigability (HP:0003388)1.78444922
175Gastrointestinal dysmotility (HP:0002579)1.76804127
176Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76694876
177Diminished movement (HP:0002374)1.73773164
178Urinary incontinence (HP:0000020)1.73277374
179Rectal fistula (HP:0100590)1.73224594
180Rectovaginal fistula (HP:0000143)1.73224594
181Recurrent skin infections (HP:0001581)1.72594659
182Rough bone trabeculation (HP:0100670)1.71680876
183Abnormality of the gallbladder (HP:0005264)1.69747926
184Bone pain (HP:0002653)1.69495022
185Nonimmune hydrops fetalis (HP:0001790)1.68465790
186Gingivitis (HP:0000230)1.68238087
187Emphysema (HP:0002097)1.67760639
188Genu recurvatum (HP:0002816)1.67392571
189Meningitis (HP:0001287)1.66754037
190Systemic lupus erythematosus (HP:0002725)1.65673416
191Flattened epiphyses (HP:0003071)1.65015452
192Facial hemangioma (HP:0000329)1.64219104
193Reticulocytosis (HP:0001923)1.64016500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.93063845
2NTRK33.93391128
3MAP3K93.41139091
4IRAK33.37855802
5DAPK23.26381431
6MAP3K113.03206132
7RIPK42.82473453
8SMG12.63285258
9NME22.62865224
10KSR22.44577701
11MAP2K42.43340775
12TESK22.35007666
13MAP3K42.29895677
14ICK2.28999576
15MAP3K132.05192710
16DAPK12.04688750
17MINK12.04182817
18EPHA21.97072575
19MAP2K71.95350222
20IRAK41.91704863
21SIK31.88301615
22BCKDK1.87907305
23CAMKK11.84689929
24MAP3K121.83410899
25PRKD31.80111451
26MAP2K31.77761071
27TBK11.77262339
28BLK1.75072422
29ARAF1.69807636
30MAP4K11.66734437
31NTRK11.63714703
32TESK11.63424319
33KSR11.57927102
34PAK61.55972421
35IRAK21.54191459
36MAP3K31.49497308
37MARK11.48960755
38EPHB11.46505765
39NTRK21.46138555
40FES1.44595674
41PIM21.41615964
42SIK21.38528717
43MAPK151.30665842
44ERN11.28513685
45RAF11.27390284
46CDK51.26823714
47PRKCG1.25071171
48RIPK11.22581905
49TAOK11.22410278
50DYRK1B1.20912944
51MAP3K21.16848313
52IKBKE1.16518518
53EEF2K1.14282665
54MAP3K71.11757338
55MAP2K21.09809238
56MATK1.05223349
57FGFR41.03095759
58PTK2B1.02867268
59STK381.01915502
60ZAP701.01002560
61PINK11.00002648
62MAP3K10.98455153
63RPS6KA20.98144556
64BMPR20.96006207
65CAMKK20.95675655
66PRKCH0.94219928
67GRK50.93881611
68GRK60.93372807
69INSRR0.92793069
70PDK10.92098336
71PDPK10.90937911
72CAMK10.90510646
73SGK30.89886714
74SGK20.87957791
75MARK20.87033655
76CAMK2A0.86977092
77SIK10.86801250
78PTK60.85569135
79PAK40.84441906
80RET0.84374424
81SGK4940.83562187
82SGK2230.83562187
83IKBKB0.82571452
84PRKCZ0.80968427
85PKN20.79390245
86PLK20.79326774
87TAOK30.78417608
88CAMK2B0.77321300
89RPS6KL10.76604350
90RPS6KC10.76604350
91CHUK0.75858263
92MAP3K140.75200771
93TRIB30.72599588
94TNIK0.70917454
95TYRO30.69872222
96CSK0.69727242
97STK110.67706648
98PRPF4B0.65164729
99SGK10.64732882
100MUSK0.62630639
101CDK190.62402488
102RPS6KA60.62207474
103MAP2K10.62015080
104TYK20.61615309
105CDC42BPA0.60052303
106CAMK2G0.59846068
107MAP3K50.59299418
108DAPK30.59159485
109MAPK120.59087992
110TNK20.57743696
111MAP2K60.57236911
112BMX0.55462068
113KDR0.54909053
114CASK0.54754669
115CAMK40.54534898
116CDK120.54237692
117PRKCQ0.53611714
118PAK30.53540618
119HIPK20.53039920
120CDK180.51072465
121CDK150.51022617
122CSNK1G20.50512291
123PNCK0.50245162
124MTOR0.49897203
125MAP3K80.49696030
126PRKG20.48430832
127MAPK110.47664495
128PRKCI0.47522954
129DDR20.46468121
130CAMK1G0.46255126
131RPS6KA30.44825668
132FYN0.44550105
133JAK20.43656771
134MAPKAPK20.43536233
135CDK140.43338403
136DYRK1A0.42917399
137BTK0.42582249
138ABL20.42252590
139TLK10.41928464
140PRKACG0.41582061
141CDK11A0.40535675
142MAP3K60.39690755
143DYRK30.39341740
144JAK30.39236139
145ERBB40.38867956
146AURKA0.38812444
147LMTK20.38048244
148BRAF0.36703923
149RPS6KA10.36677706
150CDK40.36546937
151IRAK10.36455484
152TAOK20.36199217
153PRKD20.36145836
154SYK0.35832239
155HCK0.35827581
156MAPK40.35177926
157PRKCA0.34910593
158MAP3K100.34692288
159FGFR20.34579755
160FGR0.33449724
161MAPK130.33438311
162PRKCB0.32184447

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.11744406
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.94925476
3Nitrogen metabolism_Homo sapiens_hsa009103.67712101
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.50298748
5Arginine biosynthesis_Homo sapiens_hsa002202.83510740
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.62183093
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39765771
8Fructose and mannose metabolism_Homo sapiens_hsa000512.37923666
9Lysosome_Homo sapiens_hsa041422.19866684
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09534016
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.05246047
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.97221862
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.97124394
14Complement and coagulation cascades_Homo sapiens_hsa046101.94822676
15Butanoate metabolism_Homo sapiens_hsa006501.94546481
16Osteoclast differentiation_Homo sapiens_hsa043801.91706755
17Acute myeloid leukemia_Homo sapiens_hsa052211.90570680
18Tryptophan metabolism_Homo sapiens_hsa003801.88534504
19B cell receptor signaling pathway_Homo sapiens_hsa046621.86677118
20Nicotine addiction_Homo sapiens_hsa050331.85977106
21Bladder cancer_Homo sapiens_hsa052191.79181054
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78417683
23VEGF signaling pathway_Homo sapiens_hsa043701.71010110
24Notch signaling pathway_Homo sapiens_hsa043301.69990445
25Bile secretion_Homo sapiens_hsa049761.69545608
26Fatty acid degradation_Homo sapiens_hsa000711.68880645
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68627277
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68041188
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65853984
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56015994
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55635461
32TNF signaling pathway_Homo sapiens_hsa046681.55364359
33Salmonella infection_Homo sapiens_hsa051321.53410706
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51583903
35Hepatitis C_Homo sapiens_hsa051601.49368780
36Amphetamine addiction_Homo sapiens_hsa050311.49207157
37Long-term potentiation_Homo sapiens_hsa047201.47500935
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.46372955
39GABAergic synapse_Homo sapiens_hsa047271.46190000
40Leishmaniasis_Homo sapiens_hsa051401.45652733
41Synaptic vesicle cycle_Homo sapiens_hsa047211.43749597
42Olfactory transduction_Homo sapiens_hsa047401.39853748
43Circadian entrainment_Homo sapiens_hsa047131.39456592
44Galactose metabolism_Homo sapiens_hsa000521.38626413
45PPAR signaling pathway_Homo sapiens_hsa033201.38117798
46Tuberculosis_Homo sapiens_hsa051521.37027626
47Peroxisome_Homo sapiens_hsa041461.34427662
48Glutamatergic synapse_Homo sapiens_hsa047241.33712912
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33148860
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32728526
51Propanoate metabolism_Homo sapiens_hsa006401.32438828
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31424735
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29452032
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27277387
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25857692
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23916539
57Vibrio cholerae infection_Homo sapiens_hsa051101.23288972
58Morphine addiction_Homo sapiens_hsa050321.22842548
59Apoptosis_Homo sapiens_hsa042101.22640176
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21693103
61Sphingolipid metabolism_Homo sapiens_hsa006001.21506116
62Neurotrophin signaling pathway_Homo sapiens_hsa047221.21178214
63Fatty acid metabolism_Homo sapiens_hsa012121.18603585
64Central carbon metabolism in cancer_Homo sapiens_hsa052301.18301319
65Chronic myeloid leukemia_Homo sapiens_hsa052201.18110877
66Chemical carcinogenesis_Homo sapiens_hsa052041.16905938
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16656033
68Steroid hormone biosynthesis_Homo sapiens_hsa001401.16100635
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13669278
70Shigellosis_Homo sapiens_hsa051311.13367279
71Histidine metabolism_Homo sapiens_hsa003401.11778062
72beta-Alanine metabolism_Homo sapiens_hsa004101.11680127
73Influenza A_Homo sapiens_hsa051641.11480942
74Hepatitis B_Homo sapiens_hsa051611.11257433
75Salivary secretion_Homo sapiens_hsa049701.10546900
76Non-small cell lung cancer_Homo sapiens_hsa052231.09648479
77Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08659522
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07688453
79Phenylalanine metabolism_Homo sapiens_hsa003601.05103964
80Staphylococcus aureus infection_Homo sapiens_hsa051501.03957478
81Dopaminergic synapse_Homo sapiens_hsa047281.03238813
82Pentose phosphate pathway_Homo sapiens_hsa000301.02638219
83Insulin secretion_Homo sapiens_hsa049111.02117586
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01658897
85Pyruvate metabolism_Homo sapiens_hsa006201.01633106
86Endocytosis_Homo sapiens_hsa041441.01353841
87Endometrial cancer_Homo sapiens_hsa052131.01185426
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98431256
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.96714934
90Toxoplasmosis_Homo sapiens_hsa051450.95849796
91Caffeine metabolism_Homo sapiens_hsa002320.94958836
92Cocaine addiction_Homo sapiens_hsa050300.93877511
93mTOR signaling pathway_Homo sapiens_hsa041500.93360165
94Pertussis_Homo sapiens_hsa051330.92734256
95Phagosome_Homo sapiens_hsa041450.89008279
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87535870
97Legionellosis_Homo sapiens_hsa051340.86881058
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.86854454
99Biosynthesis of amino acids_Homo sapiens_hsa012300.86522033
100Renin secretion_Homo sapiens_hsa049240.86463274
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.83868808
102Herpes simplex infection_Homo sapiens_hsa051680.83090238
103Retinol metabolism_Homo sapiens_hsa008300.83058695
104Tyrosine metabolism_Homo sapiens_hsa003500.82715450
105Cholinergic synapse_Homo sapiens_hsa047250.82360251
106ABC transporters_Homo sapiens_hsa020100.81807398
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81143502
108Starch and sucrose metabolism_Homo sapiens_hsa005000.80847720
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.80611440
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80247895
111Gastric acid secretion_Homo sapiens_hsa049710.78774962
112Prolactin signaling pathway_Homo sapiens_hsa049170.78658884
113Pancreatic cancer_Homo sapiens_hsa052120.78046628
114Fat digestion and absorption_Homo sapiens_hsa049750.77702264
115ErbB signaling pathway_Homo sapiens_hsa040120.77526161
116Rheumatoid arthritis_Homo sapiens_hsa053230.76999246
117Calcium signaling pathway_Homo sapiens_hsa040200.76855212
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75636905
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.73832028
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73492104
121Sulfur metabolism_Homo sapiens_hsa009200.73488687
122Glycerolipid metabolism_Homo sapiens_hsa005610.73447224
123Taste transduction_Homo sapiens_hsa047420.73132393
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73002906
125Carbon metabolism_Homo sapiens_hsa012000.71684054
126Insulin signaling pathway_Homo sapiens_hsa049100.70728630
127Malaria_Homo sapiens_hsa051440.69574896
128T cell receptor signaling pathway_Homo sapiens_hsa046600.68285873
129Oxytocin signaling pathway_Homo sapiens_hsa049210.67127787
130Epstein-Barr virus infection_Homo sapiens_hsa051690.67080610
131Chemokine signaling pathway_Homo sapiens_hsa040620.67067606
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65678739
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65605917
134Selenocompound metabolism_Homo sapiens_hsa004500.64138701
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.64114956
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63379531
137AMPK signaling pathway_Homo sapiens_hsa041520.62229106
138Renal cell carcinoma_Homo sapiens_hsa052110.61766570
139Prion diseases_Homo sapiens_hsa050200.60836722
140Glucagon signaling pathway_Homo sapiens_hsa049220.60257179
141Long-term depression_Homo sapiens_hsa047300.59588266
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59321709
143Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59247602
144Base excision repair_Homo sapiens_hsa034100.59132032
145Viral carcinogenesis_Homo sapiens_hsa052030.57525890
146Inositol phosphate metabolism_Homo sapiens_hsa005620.56770542
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.56202055
148Type II diabetes mellitus_Homo sapiens_hsa049300.56042013
149Insulin resistance_Homo sapiens_hsa049310.55830145
150Serotonergic synapse_Homo sapiens_hsa047260.55710830
151GnRH signaling pathway_Homo sapiens_hsa049120.54470695
152Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54283208
153HTLV-I infection_Homo sapiens_hsa051660.54026007
154Measles_Homo sapiens_hsa051620.53345145
155Maturity onset diabetes of the young_Homo sapiens_hsa049500.52719317
156Allograft rejection_Homo sapiens_hsa053300.50119895
157AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50105713
158cAMP signaling pathway_Homo sapiens_hsa040240.49976768
159Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48328487
160Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47936060
161Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47497625
162Viral myocarditis_Homo sapiens_hsa054160.46136539
163HIF-1 signaling pathway_Homo sapiens_hsa040660.45855193
164Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45816957
165Fatty acid elongation_Homo sapiens_hsa000620.45535612
166Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45386007
167Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44505664
168Fatty acid biosynthesis_Homo sapiens_hsa000610.44267830
169Colorectal cancer_Homo sapiens_hsa052100.44042784
170MAPK signaling pathway_Homo sapiens_hsa040100.43963046
171Pancreatic secretion_Homo sapiens_hsa049720.43872059
172Choline metabolism in cancer_Homo sapiens_hsa052310.43321676
173Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42620323
174Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41821641
175Thyroid hormone synthesis_Homo sapiens_hsa049180.39309252
176Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39298990
177Collecting duct acid secretion_Homo sapiens_hsa049660.39241727
178Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38782426
179Gap junction_Homo sapiens_hsa045400.37438829
180Arginine and proline metabolism_Homo sapiens_hsa003300.35543366
181Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34900144
182Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33669593
183Sulfur relay system_Homo sapiens_hsa041220.33180635
184Glioma_Homo sapiens_hsa052140.33155987
185Estrogen signaling pathway_Homo sapiens_hsa049150.32806766

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