ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of digestive system process (GO:0060456)	7.55474055
2	protein K11-linked deubiquitination (GO:0035871)	7.51902438
3	adaptation of signaling pathway (GO:0023058)	5.53925695
4	flavonoid metabolic process (GO:0009812)	5.07794339
5	serotonin receptor signaling pathway (GO:0007210)	5.05591736
6	cochlea development (GO:0090102)	4.96889830
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.57173824
8	response to histamine (GO:0034776)	4.31279479
9	negative regulation of systemic arterial blood pressure (GO:0003085)	4.20064704
10	inner ear receptor cell development (GO:0060119)	4.13521636
11	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.11351553
12	sulfation (GO:0051923)	4.09102444
13	detection of light stimulus involved in sensory perception (GO:0050962)	4.08193893
14	detection of light stimulus involved in visual perception (GO:0050908)	4.08193893
15	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	4.03846059
16	behavioral response to nicotine (GO:0035095)	3.97725888
17	NAD biosynthetic process (GO:0009435)	3.80577206
18	negative regulation of metanephros development (GO:0072217)	3.73908868
19	indole-containing compound catabolic process (GO:0042436)	3.47598595
20	indolalkylamine catabolic process (GO:0046218)	3.47598595
21	tryptophan catabolic process (GO:0006569)	3.47598595
22	innervation (GO:0060384)	3.44817754
23	adrenergic receptor signaling pathway (GO:0071875)	3.36156792
24	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.34523335
25	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.28234462
26	L-fucose catabolic process (GO:0042355)	3.26652347
27	fucose catabolic process (GO:0019317)	3.26652347
28	L-fucose metabolic process (GO:0042354)	3.26652347
29	response to pheromone (GO:0019236)	3.26008937
30	DNA double-strand break processing (GO:0000729)	3.25909420
31	cell differentiation involved in metanephros development (GO:0072202)	3.21617049
32	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.16942423
33	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.16942423
34	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.16390608
35	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.16390608
36	nephron tubule formation (GO:0072079)	3.15861851
37	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.15430673
38	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.11966778
39	righting reflex (GO:0060013)	3.06899592
40	negative regulation by host of viral transcription (GO:0043922)	3.05307574
41	activated T cell proliferation (GO:0050798)	3.04186185
42	reflex (GO:0060004)	3.01371363
43	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.01208392
44	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	2.99662300
45	auditory receptor cell stereocilium organization (GO:0060088)	2.98806554
46	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.97413277
47	indolalkylamine metabolic process (GO:0006586)	2.97235765
48	negative regulation of mast cell activation (GO:0033004)	2.96717174
49	tryptophan metabolic process (GO:0006568)	2.95795824
50	organic cation transport (GO:0015695)	2.95674005
51	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.95373219
52	regulation of germinal center formation (GO:0002634)	2.94680199
53	L-methionine salvage (GO:0071267)	2.92220043
54	L-methionine biosynthetic process (GO:0071265)	2.92220043
55	amino acid salvage (GO:0043102)	2.92220043
56	regulation of appetite (GO:0032098)	2.91534409
57	rRNA catabolic process (GO:0016075)	2.91259268
58	axoneme assembly (GO:0035082)	2.90321533
59	protein-cofactor linkage (GO:0018065)	2.86414259
60	regulation of hippo signaling (GO:0035330)	2.81436969
61	cellular ketone body metabolic process (GO:0046950)	2.81280383
62	piRNA metabolic process (GO:0034587)	2.81264399
63	regulation of glomerulus development (GO:0090192)	2.80345820
64	cornea development in camera-type eye (GO:0061303)	2.80289621
65	pyridine nucleotide biosynthetic process (GO:0019363)	2.79682585
66	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.79682585
67	regulation of timing of cell differentiation (GO:0048505)	2.78625345
68	startle response (GO:0001964)	2.78427355
69	thyroid hormone metabolic process (GO:0042403)	2.78363090
70	glycerophospholipid catabolic process (GO:0046475)	2.78339950
71	metanephric mesenchyme development (GO:0072075)	2.77930277
72	nuclear pore organization (GO:0006999)	2.76312623
73	amino-acid betaine metabolic process (GO:0006577)	2.75784046
74	kynurenine metabolic process (GO:0070189)	2.75114093
75	positive regulation of glomerulus development (GO:0090193)	2.74548574
76	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.73312266
77	ncRNA 3-end processing (GO:0043628)	2.72588313
78	negative regulation of multicellular organism growth (GO:0040015)	2.71829783
79	lymphangiogenesis (GO:0001946)	2.71060536
80	protein K48-linked deubiquitination (GO:0071108)	2.70969298
81	negative regulation of interleukin-8 production (GO:0032717)	2.70932385
82	regulation of sarcomere organization (GO:0060297)	2.70439077
83	establishment of protein localization to Golgi (GO:0072600)	2.69880100
84	positive regulation of guanylate cyclase activity (GO:0031284)	2.69725795
85	embryonic epithelial tube formation (GO:0001838)	2.69152698
86	transepithelial transport (GO:0070633)	2.69015628
87	regulation of digestive system process (GO:0044058)	2.68882175
88	rhodopsin mediated signaling pathway (GO:0016056)	2.68240251
89	coenzyme catabolic process (GO:0009109)	2.68108859
90	retinal cone cell development (GO:0046549)	2.67896302
91	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.65727134
92	brain morphogenesis (GO:0048854)	2.64413528
93	angiogenesis involved in wound healing (GO:0060055)	2.63048672
94	protein K63-linked deubiquitination (GO:0070536)	2.62372647
95	neural tube formation (GO:0001841)	2.61998575
96	negative regulation of astrocyte differentiation (GO:0048712)	2.61787969
97	cAMP catabolic process (GO:0006198)	2.59665123
98	photoreceptor cell maintenance (GO:0045494)	2.58407432
99	alanine transport (GO:0032328)	2.54257168
100	tachykinin receptor signaling pathway (GO:0007217)	10.3687583

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.93299682
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.87366878
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.74647383
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.94389044
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.81763830
6	VDR_22108803_ChIP-Seq_LS180_Human	2.64854551
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.63025960
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.42991844
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37273390
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.14107394
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.09685691
12	P300_19829295_ChIP-Seq_ESCs_Human	2.02807357
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.02389173
14	ER_23166858_ChIP-Seq_MCF-7_Human	1.97581945
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97230484
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.96509205
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.92743807
18	BCAT_22108803_ChIP-Seq_LS180_Human	1.88090993
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.80711301
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.79552269
21	EWS_26573619_Chip-Seq_HEK293_Human	1.79038191
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.77412273
23	STAT3_23295773_ChIP-Seq_U87_Human	1.73895653
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.71918779
25	AR_25329375_ChIP-Seq_VCAP_Human	1.71681419
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71543692
27	FUS_26573619_Chip-Seq_HEK293_Human	1.66247041
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.65799630
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.64876424
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.64700038
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.64700038
32	AR_21572438_ChIP-Seq_LNCaP_Human	1.61649931
33	TCF4_23295773_ChIP-Seq_U87_Human	1.61400372
34	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.58692096
35	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.55506313
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54774395
37	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51947006
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.50621018
39	TCF4_22108803_ChIP-Seq_LS180_Human	1.48379051
40	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.47615476
41	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.46929887
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.46430736
43	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.45601168
44	RUNX2_22187159_ChIP-Seq_PCA_Human	1.45164454
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.42554467
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40028377
47	REST_21632747_ChIP-Seq_MESCs_Mouse	1.37189249
48	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.33080015
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30665470
50	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.30007320
51	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.29757828
52	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28974491
53	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.28789755
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28770321
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28611638
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.27627793
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26569923
58	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25958239
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25886397
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24078949
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21408711
62	CDX2_22108803_ChIP-Seq_LS180_Human	1.21162044
63	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.19220860
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18835192
65	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18354225
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.17084024
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16796557
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15797058
69	TP53_16413492_ChIP-PET_HCT116_Human	1.14561988
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13358183
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13358183
72	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.12798396
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12464892
74	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.10288311
75	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09954423
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09892664
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09757360
78	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.09728662
79	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09728662
80	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.09483695
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09359292
82	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07257364
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05678625
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04870745
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04018186
86	DROSHA_22980978_ChIP-Seq_HELA_Human	1.02448528
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01768529
88	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01696340
89	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01660137
90	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01660137
91	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01274322
92	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.00240762
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00110205
94	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.99764742
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98522589
96	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.96475233
97	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.96225144
98	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.95845996
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95302946
100	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.95234946

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	5.43873938
2	MP0003646_muscle_fatigue	3.19893481
3	MP0005551_abnormal_eye_electrophysiolog	3.02393041
4	MP0001501_abnormal_sleep_pattern	2.76436583
5	MP0000372_irregular_coat_pigmentation	2.72719013
6	MP0004043_abnormal_pH_regulation	2.71213315
7	MP0008875_abnormal_xenobiotic_pharmacok	2.70279731
8	MP0006276_abnormal_autonomic_nervous	2.55587606
9	MP0008872_abnormal_physiological_respon	2.40658305
10	MP0005645_abnormal_hypothalamus_physiol	2.20013838
11	MP0010386_abnormal_urinary_bladder	2.13769123
12	MP0002254_reproductive_system_inflammat	2.13659024
13	MP0001984_abnormal_olfaction	2.00413035
14	MP0002735_abnormal_chemical_nociception	1.97301059
15	MP0001968_abnormal_touch/_nociception	1.90513742
16	MP0000569_abnormal_digit_pigmentation	1.89444391
17	MP0009745_abnormal_behavioral_response	1.87622709
18	MP0002736_abnormal_nociception_after	1.81721647
19	MP0009046_muscle_twitch	1.81203836
20	MP0005646_abnormal_pituitary_gland	1.79694284
21	MP0008877_abnormal_DNA_methylation	1.79077836
22	MP0003136_yellow_coat_color	1.71897155
23	MP0002138_abnormal_hepatobiliary_system	1.69989488
24	MP0001879_abnormal_lymphatic_vessel	1.64391848
25	MP0002837_dystrophic_cardiac_calcinosis	1.64149884
26	MP0005253_abnormal_eye_physiology	1.61027080
27	MP0000631_abnormal_neuroendocrine_gland	1.57811859
28	MP0005310_abnormal_salivary_gland	1.57115760
29	MP0002876_abnormal_thyroid_physiology	1.56999599
30	MP0005084_abnormal_gallbladder_morpholo	1.47489747
31	MP0005647_abnormal_sex_gland	1.45163293
32	MP0003183_abnormal_peptide_metabolism	1.44028829
33	MP0001486_abnormal_startle_reflex	1.39168515
34	MP0003787_abnormal_imprinting	1.38661999
35	MP0001324_abnormal_eye_pigmentation	1.38350824
36	MP0009780_abnormal_chondrocyte_physiolo	1.37097484
37	MP0001970_abnormal_pain_threshold	1.36432590
38	MP0002572_abnormal_emotion/affect_behav	1.33063926
39	MP0002928_abnormal_bile_duct	1.32622751
40	MP0002234_abnormal_pharynx_morphology	1.31712852
41	MP0004142_abnormal_muscle_tone	1.31404949
42	MP0002064_seizures	1.30548023
43	MP0004885_abnormal_endolymph	1.26786224
44	MP0002272_abnormal_nervous_system	1.25823244
45	MP0003635_abnormal_synaptic_transmissio	1.23301394
46	MP0002184_abnormal_innervation	1.22486697
47	MP0001485_abnormal_pinna_reflex	1.21508287
48	MP0001873_stomach_inflammation	1.20444108
49	MP0002751_abnormal_autonomic_nervous	1.19443967
50	MP0000230_abnormal_systemic_arterial	1.17615539
51	MP0002909_abnormal_adrenal_gland	1.17017161
52	MP0002090_abnormal_vision	1.15126173
53	MP0002638_abnormal_pupillary_reflex	1.14456568
54	MP0003718_maternal_effect	1.14104036
55	MP0000026_abnormal_inner_ear	1.13136827
56	MP0005174_abnormal_tail_pigmentation	1.11522590
57	MP0004215_abnormal_myocardial_fiber	1.10592866
58	MP0002168_other_aberrant_phenotype	1.08510562
59	MP0002557_abnormal_social/conspecific_i	1.06061086
60	MP0002733_abnormal_thermal_nociception	1.04835273
61	MP0002063_abnormal_learning/memory/cond	1.04756081
62	MP0002229_neurodegeneration	1.04508713
63	MP0004147_increased_porphyrin_level	1.04302219
64	MP0001440_abnormal_grooming_behavior	1.03718602
65	MP0005389_reproductive_system_phenotype	1.03124358
66	MP0003943_abnormal_hepatobiliary_system	0.99542700
67	MP0001919_abnormal_reproductive_system	0.99056949
68	MP0005670_abnormal_white_adipose	0.97764574
69	MP0005085_abnormal_gallbladder_physiolo	0.95525261
70	MP0001963_abnormal_hearing_physiology	0.95335446
71	MP0005167_abnormal_blood-brain_barrier	0.95086589
72	MP0005195_abnormal_posterior_eye	0.93067205
73	MP0000427_abnormal_hair_cycle	0.92187310
74	MP0004484_altered_response_of	0.90874014
75	MP0002752_abnormal_somatic_nervous	0.90737111
76	MP0000383_abnormal_hair_follicle	0.90590904
77	MP0004085_abnormal_heartbeat	0.88964777
78	MP0004145_abnormal_muscle_electrophysio	0.88476274
79	MP0000639_abnormal_adrenal_gland	0.87824402
80	MP0004742_abnormal_vestibular_system	0.87816904
81	MP0002067_abnormal_sensory_capabilities	0.87569534
82	MP0005395_other_phenotype	0.87181702
83	MP0003878_abnormal_ear_physiology	0.85431324
84	MP0005377_hearing/vestibular/ear_phenot	0.85431324
85	MP0003880_abnormal_central_pattern	0.82948089
86	MP0002734_abnormal_mechanical_nocicepti	0.81410323
87	MP0003045_fibrosis	0.81334850
88	MP0001986_abnormal_taste_sensitivity	0.80542054
89	MP0000534_abnormal_ureter_morphology	0.78878823
90	MP0004133_heterotaxia	0.78672019
91	MP0002139_abnormal_hepatobiliary_system	0.77423478
92	MP0000015_abnormal_ear_pigmentation	0.75267346
93	MP0003806_abnormal_nucleotide_metabolis	0.74610482
94	MP0001764_abnormal_homeostasis	0.74480464
95	MP0002693_abnormal_pancreas_physiology	0.74215072
96	MP0005075_abnormal_melanosome_morpholog	0.73984804
97	MP0000778_abnormal_nervous_system	0.73817665
98	MP0003936_abnormal_reproductive_system	0.72210264
99	MP0001905_abnormal_dopamine_level	0.71133426
100	MP0005332_abnormal_amino_acid	0.70242709

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of macular pigmentation (HP:0008002)	5.82552210
2	Decreased central vision (HP:0007663)	4.79512517
3	True hermaphroditism (HP:0010459)	4.36364209
4	Attenuation of retinal blood vessels (HP:0007843)	4.28282224
5	Pancreatic cysts (HP:0001737)	4.24607733
6	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.15185017
7	Congenital stationary night blindness (HP:0007642)	4.13409123
8	Poikiloderma (HP:0001029)	4.13343885
9	Pancreatic fibrosis (HP:0100732)	4.07468118
10	Decreased circulating renin level (HP:0003351)	3.47887401
11	Congenital sensorineural hearing impairment (HP:0008527)	3.39604500
12	Hyperventilation (HP:0002883)	3.37990654
13	Chorioretinal atrophy (HP:0000533)	3.27684535
14	Abolished electroretinogram (ERG) (HP:0000550)	3.10585958
15	Macular degeneration (HP:0000608)	3.08701892
16	Abnormality of the renal cortex (HP:0011035)	3.06811744
17	Constricted visual fields (HP:0001133)	3.01547977
18	Dyschromatopsia (HP:0007641)	2.97244164
19	Abnormal drinking behavior (HP:0030082)	2.89612389
20	Polydipsia (HP:0001959)	2.89612389
21	Progressive inability to walk (HP:0002505)	2.88635926
22	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.88596606
23	Molar tooth sign on MRI (HP:0002419)	2.81985467
24	Abnormality of midbrain morphology (HP:0002418)	2.81985467
25	Nephronophthisis (HP:0000090)	2.77686136
26	Abnormality of the renal medulla (HP:0100957)	2.77438893
27	Chronic hepatic failure (HP:0100626)	2.75194410
28	Episodic fever (HP:0001954)	2.73634652
29	Genital tract atresia (HP:0001827)	2.72198447
30	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.65719678
31	Hypophosphatemic rickets (HP:0004912)	2.62860811
32	Potter facies (HP:0002009)	2.61182632
33	Facial shape deformation (HP:0011334)	2.61182632
34	Arthropathy (HP:0003040)	2.55936339
35	Vaginal atresia (HP:0000148)	2.48351869
36	Medial flaring of the eyebrow (HP:0010747)	2.45131125
37	Absent speech (HP:0001344)	2.44095279
38	Bicornuate uterus (HP:0000813)	2.42106283
39	Cystic liver disease (HP:0006706)	2.36267362
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.34214731
41	Aplasia/hypoplasia of the uterus (HP:0008684)	2.33587378
42	Polyuria (HP:0000103)	2.31994582
43	Nephrogenic diabetes insipidus (HP:0009806)	2.26322901
44	Gait imbalance (HP:0002141)	2.23469897
45	Male pseudohermaphroditism (HP:0000037)	2.23380211
46	Hyperaldosteronism (HP:0000859)	2.20207161
47	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.17892426
48	Type II lissencephaly (HP:0007260)	2.17715081
49	Congenital primary aphakia (HP:0007707)	2.17647578
50	Bony spicule pigmentary retinopathy (HP:0007737)	2.17221847
51	Stomatitis (HP:0010280)	2.17177276
52	Furrowed tongue (HP:0000221)	2.17075100
53	Choroideremia (HP:0001139)	2.13902290
54	Inability to walk (HP:0002540)	2.12666903
55	Hypoplasia of the uterus (HP:0000013)	2.11536347
56	Fair hair (HP:0002286)	2.11316494
57	Tubular atrophy (HP:0000092)	2.10050342
58	Abnormal biliary tract physiology (HP:0012439)	2.08346904
59	Bile duct proliferation (HP:0001408)	2.08346904
60	Abnormality of dental color (HP:0011073)	2.07447190
61	Large for gestational age (HP:0001520)	1.99909164
62	Asplenia (HP:0001746)	1.98719915
63	Volvulus (HP:0002580)	1.98117095
64	Gaze-evoked nystagmus (HP:0000640)	1.97024247
65	Generalized hypopigmentation of hair (HP:0011358)	1.94117829
66	Widely spaced teeth (HP:0000687)	1.92821562
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.91658002
68	Ketoacidosis (HP:0001993)	1.91429493
69	Oligohydramnios (HP:0001562)	1.89640019
70	Abnormal urine output (HP:0012590)	1.88243742
71	Ketosis (HP:0001946)	1.84951473
72	Renal cortical cysts (HP:0000803)	1.84638020
73	Abnormality of renin-angiotensin system (HP:0000847)	1.84298140
74	Unilateral renal agenesis (HP:0000122)	1.84273968
75	Hyperglycinuria (HP:0003108)	1.83959314
76	Astigmatism (HP:0000483)	1.83463910
77	Stage 5 chronic kidney disease (HP:0003774)	1.83260647
78	Small hand (HP:0200055)	1.82743609
79	Lissencephaly (HP:0001339)	1.81772108
80	Anencephaly (HP:0002323)	1.80673099
81	Poor coordination (HP:0002370)	1.80049938
82	Keratoconus (HP:0000563)	1.79383804
83	Increased corneal curvature (HP:0100692)	1.79383804
84	Postaxial foot polydactyly (HP:0001830)	1.79254140
85	Type II diabetes mellitus (HP:0005978)	1.78662016
86	Autoamputation (HP:0001218)	1.78378611
87	Hypoplasia of the fovea (HP:0007750)	1.78168767
88	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.78168767
89	Hypokalemic alkalosis (HP:0001949)	1.77134687
90	Congenital hepatic fibrosis (HP:0002612)	1.75440593
91	Sclerocornea (HP:0000647)	1.74230296
92	Recurrent sinusitis (HP:0011108)	1.73759778
93	Febrile seizures (HP:0002373)	1.73628962
94	Anhidrosis (HP:0000970)	1.71109600
95	Abnormal pancreas size (HP:0012094)	1.71068331
96	Hypokalemia (HP:0002900)	1.70826422
97	Photophobia (HP:0000613)	1.70542189
98	Amelogenesis imperfecta (HP:0000705)	1.68181057
99	Albinism (HP:0001022)	1.68010515
100	Prolonged QT interval (HP:0001657)	1.67818245

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.99709208
2	WNK3	4.58765090
3	PINK1	2.68157600
4	MAP4K2	2.58487258
5	ADRBK2	2.53890430
6	ZAK	2.53282559
7	TNIK	2.38612601
8	NEK6	2.24799545
9	STK39	2.04416848
10	STK38L	1.98319572
11	BMPR1B	1.92805089
12	GRK1	1.87001619
13	MAP2K7	1.81079038
14	MAP3K4	1.77510330
15	TXK	1.76966037
16	MAPK13	1.71756918
17	NUAK1	1.69216862
18	CSNK1A1L	1.64441764
19	CASK	1.61386358
20	TAOK3	1.57646603
21	OXSR1	1.54515807
22	WNK4	1.52432644
23	INSRR	1.41874876
24	ACVR1B	1.39424502
25	TLK1	1.29030880
26	MST4	1.21164139
27	MATK	1.21098131
28	DAPK2	1.17775611
29	FER	1.14432389
30	PRKD3	1.14202332
31	NTRK1	1.10244392
32	MAPKAPK3	1.08380060
33	EIF2AK3	1.07012833
34	IRAK1	1.03693139
35	MKNK2	1.03457729
36	ADRBK1	0.99324386
37	MAP2K6	0.95227125
38	CSNK1G2	0.92007726
39	MARK1	0.90719550
40	KIT	0.89576754
41	GRK7	0.87516459
42	WNK1	0.86208313
43	ICK	0.85562604
44	PRKCE	0.85145719
45	CSNK1G1	0.83731165
46	TIE1	0.83517087
47	CSNK1G3	0.82802138
48	PAK3	0.78819204
49	NLK	0.73533860
50	NTRK3	0.73313015
51	PLK2	0.68302156
52	PNCK	0.67201136
53	TAF1	0.66532425
54	TRIM28	0.66151237
55	CAMK1G	0.63877755
56	PKN1	0.60677014
57	VRK1	0.58176144
58	TNK2	0.58085264
59	NEK1	0.57863148
60	CAMK1D	0.56806372
61	DYRK2	0.56549884
62	CAMK1	0.53704173
63	MAPKAPK5	0.52742028
64	PRKCZ	0.51859551
65	TRPM7	0.51329786
66	AKT3	0.50841367
67	PRKCG	0.49294940
68	LATS1	0.47593572
69	PRKAA2	0.47341187
70	PIK3CG	0.46327605
71	MAP2K4	0.45512576
72	STK11	0.44532146
73	LIMK1	0.44299577
74	CAMK4	0.42685289
75	PTK2B	0.41825819
76	SRPK1	0.41394020
77	MKNK1	0.41353891
78	MAP3K7	0.41097445
79	STK3	0.40978004
80	YES1	0.40919465
81	CSNK1A1	0.39289997
82	SIK2	0.38948892
83	ERBB3	0.38909167
84	FLT3	0.38430055
85	PRKD2	0.37960646
86	CAMK2A	0.37722286
87	IGF1R	0.37306787
88	DAPK1	0.37193421
89	ATM	0.36990778
90	PRKCA	0.36844763
91	NEK2	0.36594610
92	EPHA3	0.34129446
93	GRK5	0.31852568
94	PLK3	0.31844771
95	BLK	0.31795907
96	CDK3	0.31542749
97	PHKG1	0.31271016
98	PHKG2	0.31271016
99	PRKG1	0.29279581
100	PRKACA	0.27562808

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.81046304
2	Phototransduction_Homo sapiens_hsa04744	3.00665784
3	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.31883194
4	Caffeine metabolism_Homo sapiens_hsa00232	2.27845146
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.22990393
6	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.21958167
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.17720682
8	Morphine addiction_Homo sapiens_hsa05032	2.17405192
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.15758527
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.09858848
11	Butanoate metabolism_Homo sapiens_hsa00650	2.04476766
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.99732089
13	Ether lipid metabolism_Homo sapiens_hsa00565	1.93756891
14	Glycerolipid metabolism_Homo sapiens_hsa00561	1.82051618
15	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.81408570
16	Olfactory transduction_Homo sapiens_hsa04740	1.80556147
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.80225589
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.78142631
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.70203099
20	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.68338974
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.67932589
22	Serotonergic synapse_Homo sapiens_hsa04726	1.64296849
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.58476460
24	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.58335271
25	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.55523081
26	Propanoate metabolism_Homo sapiens_hsa00640	1.55252550
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.54680814
28	GABAergic synapse_Homo sapiens_hsa04727	1.53847577
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.44883646
30	Salivary secretion_Homo sapiens_hsa04970	1.44753725
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37909455
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.37715848
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.28374730
34	ABC transporters_Homo sapiens_hsa02010	1.22174059
35	Histidine metabolism_Homo sapiens_hsa00340	1.21654911
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.19752690
37	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.18619417
38	Primary immunodeficiency_Homo sapiens_hsa05340	1.14162363
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.12884965
40	Taste transduction_Homo sapiens_hsa04742	1.08634716
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.06250953
42	Retinol metabolism_Homo sapiens_hsa00830	1.05358475
43	Asthma_Homo sapiens_hsa05310	1.05090524
44	Calcium signaling pathway_Homo sapiens_hsa04020	1.03229849
45	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.03074513
46	Collecting duct acid secretion_Homo sapiens_hsa04966	1.01445242
47	Protein export_Homo sapiens_hsa03060	1.00738613
48	RNA degradation_Homo sapiens_hsa03018	0.98751068
49	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97481670
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.96416464
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.96167527
52	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95283534
53	Basal transcription factors_Homo sapiens_hsa03022	0.93249111
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90926277
55	Peroxisome_Homo sapiens_hsa04146	0.89128770
56	Glutathione metabolism_Homo sapiens_hsa00480	0.88240890
57	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.87427264
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84304723
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.81755589
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80186628
61	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.78799129
62	Insulin secretion_Homo sapiens_hsa04911	0.77847475
63	Homologous recombination_Homo sapiens_hsa03440	0.75144014
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.70343012
65	Oxidative phosphorylation_Homo sapiens_hsa00190	0.68511536
66	Circadian rhythm_Homo sapiens_hsa04710	0.64878374
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64138754
68	Circadian entrainment_Homo sapiens_hsa04713	0.64063285
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.62206075
70	RNA polymerase_Homo sapiens_hsa03020	0.62135635
71	Gastric acid secretion_Homo sapiens_hsa04971	0.61075298
72	Proteasome_Homo sapiens_hsa03050	0.58855341
73	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.58370465
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.58338903
75	One carbon pool by folate_Homo sapiens_hsa00670	0.57339596
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57275958
77	Renin secretion_Homo sapiens_hsa04924	0.56201135
78	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.55560937
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.54465655
80	Cocaine addiction_Homo sapiens_hsa05030	0.53467407
81	Regulation of autophagy_Homo sapiens_hsa04140	0.53365635
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.52744816
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.52299324
84	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.50891260
85	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.50590285
86	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.47319487
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44553795
88	Metabolic pathways_Homo sapiens_hsa01100	0.43527034
89	Lysine degradation_Homo sapiens_hsa00310	0.42946516
90	Fatty acid degradation_Homo sapiens_hsa00071	0.38731995
91	RNA transport_Homo sapiens_hsa03013	0.38021091
92	Cholinergic synapse_Homo sapiens_hsa04725	0.38009608
93	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.37065095
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.36654652
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36443812
96	Sphingolipid metabolism_Homo sapiens_hsa00600	0.36407206
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35389295
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.34202490
99	Purine metabolism_Homo sapiens_hsa00230	0.32705574
100	Sulfur metabolism_Homo sapiens_hsa00920	0.27393041

SPATA2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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