SPATA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.88999548
2axonemal dynein complex assembly (GO:0070286)9.86216527
3motile cilium assembly (GO:0044458)9.44626947
4cilium or flagellum-dependent cell motility (GO:0001539)9.27600589
5reproduction (GO:0000003)9.11253313
6regulation of cilium movement (GO:0003352)9.04540978
7response to pheromone (GO:0019236)8.57937641
8cilium movement (GO:0003341)8.16460901
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.62032726
10sperm capacitation (GO:0048240)7.55599626
11single fertilization (GO:0007338)7.42479801
12negative regulation of inclusion body assembly (GO:0090084)7.37599936
13rRNA methylation (GO:0031167)7.05642391
14organic cation transport (GO:0015695)6.99358784
15phosphatidylethanolamine biosynthetic process (GO:0006646)6.89539134
16synaptonemal complex organization (GO:0070193)6.85958126
17spermatogenesis (GO:0007283)6.81324788
18male gamete generation (GO:0048232)6.78794815
19protein targeting to Golgi (GO:0000042)6.77029175
20piRNA metabolic process (GO:0034587)6.71226950
21synaptonemal complex assembly (GO:0007130)6.65053284
22male meiosis (GO:0007140)6.62107913
23establishment of protein localization to Golgi (GO:0072600)6.51458321
24microtubule depolymerization (GO:0007019)6.47053250
25regulation of inclusion body assembly (GO:0090083)6.42354253
26phosphatidylethanolamine metabolic process (GO:0046337)6.36264716
27retrograde transport, vesicle recycling within Golgi (GO:0000301)6.31794654
28fertilization (GO:0009566)6.29566152
29gamete generation (GO:0007276)6.23622536
30rRNA modification (GO:0000154)5.92308694
31calcium ion-dependent exocytosis (GO:0017156)5.72739433
32centriole replication (GO:0007099)5.57153971
33cellular ketone body metabolic process (GO:0046950)5.56301581
34germ cell development (GO:0007281)5.48239759
35cellular process involved in reproduction in multicellular organism (GO:0022412)5.41549714
36regulation of microtubule-based movement (GO:0060632)5.34447884
37ventricular system development (GO:0021591)5.29039459
38chromosome condensation (GO:0030261)5.24090271
39glycerol ether metabolic process (GO:0006662)5.10081949
40DNA packaging (GO:0006323)5.03181951
41cell recognition (GO:0008037)5.00260073
42multicellular organismal reproductive process (GO:0048609)4.92395542
43centriole assembly (GO:0098534)4.90649301
44ketone body metabolic process (GO:1902224)4.90534809
45regulation of Rab GTPase activity (GO:0032313)4.89600538
46positive regulation of Rab GTPase activity (GO:0032851)4.89600538
47seminiferous tubule development (GO:0072520)4.89269763
48protein localization to Golgi apparatus (GO:0034067)4.84137364
49male meiosis I (GO:0007141)4.81918527
50spermatid nucleus differentiation (GO:0007289)4.78366467
51microtubule severing (GO:0051013)4.73298606
52ether metabolic process (GO:0018904)4.70906891
53left/right pattern formation (GO:0060972)4.63005001
54regulation of transcription involved in cell fate commitment (GO:0060850)4.55371676
55chromosome organization involved in meiosis (GO:0070192)4.43004999
56regulation of centriole replication (GO:0046599)4.40303097
57DNA methylation involved in gamete generation (GO:0043046)4.25087222
58chaperone-mediated protein complex assembly (GO:0051131)4.16766045
59sexual reproduction (GO:0019953)4.13086077
60meiotic nuclear division (GO:0007126)4.01073443
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97945523
62single strand break repair (GO:0000012)3.97602929
63multicellular organismal development (GO:0007275)3.95709968
64multicellular organismal movement (GO:0050879)3.84910068
65musculoskeletal movement (GO:0050881)3.84910068
66meiosis I (GO:0007127)3.81900765
67negative regulation of Rho protein signal transduction (GO:0035024)3.79647011
68regulation of somitogenesis (GO:0014807)3.76682022
69protein polyglutamylation (GO:0018095)3.58288450
70genitalia morphogenesis (GO:0035112)3.55255302
71coenzyme catabolic process (GO:0009109)3.50007217
72regulation of interleukin-13 production (GO:0032656)3.43687964
73response to acidic pH (GO:0010447)3.43498325
74peptidyl-threonine dephosphorylation (GO:0035970)3.41177249
75RNA localization (GO:0006403)3.39289600
76sequestering of actin monomers (GO:0042989)3.36779621
77cellular response to pH (GO:0071467)3.35371874
78protein-DNA complex disassembly (GO:0032986)3.33181432
79nucleosome disassembly (GO:0006337)3.33181432
80regulation of spindle checkpoint (GO:0090231)3.31544980
81protein refolding (GO:0042026)3.30887533
82microtubule polymerization or depolymerization (GO:0031109)3.29060034
83microtubule nucleation (GO:0007020)3.27264959
84cerebral cortex neuron differentiation (GO:0021895)3.26402871
85protein localization to cilium (GO:0061512)3.23883976
86membrane protein intracellular domain proteolysis (GO:0031293)3.23747256
87glycolytic process (GO:0006096)3.20553554
88meiotic cell cycle (GO:0051321)3.19734504
89homeostasis of number of cells within a tissue (GO:0048873)3.16730197
90amino-acid betaine transport (GO:0015838)3.16618803
91carnitine transport (GO:0015879)3.16618803
92cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.13054282
93protein K11-linked deubiquitination (GO:0035871)3.09717213
94glomerular visceral epithelial cell development (GO:0072015)3.07636997
95RNA destabilization (GO:0050779)3.07043594
96nucleus organization (GO:0006997)3.06226404
97histone H3-K9 demethylation (GO:0033169)3.04008364
98polyamine biosynthetic process (GO:0006596)3.03090625
99negative regulation of gene expression, epigenetic (GO:0045814)3.01417557
100cranial nerve morphogenesis (GO:0021602)3.00495612
101regulation of T-helper 2 cell differentiation (GO:0045628)2.99521282
102glomerular epithelial cell development (GO:0072310)2.99257180
103protein depolymerization (GO:0051261)2.98163734
104carnitine transmembrane transport (GO:1902603)2.96101390
105interferon-gamma secretion (GO:0072643)2.94115516
106positive regulation of macrophage activation (GO:0043032)2.93520194
107regulation of phosphoprotein phosphatase activity (GO:0043666)2.91119720
108polyol catabolic process (GO:0046174)2.86663928
109negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.86357276
110alditol metabolic process (GO:0019400)2.85596471
111mitotic sister chromatid cohesion (GO:0007064)2.85562122
112mitochondrial fission (GO:0000266)2.85498842
113monoubiquitinated protein deubiquitination (GO:0035520)2.85400467
114DNA conformation change (GO:0071103)2.85259984
115nucleoside diphosphate phosphorylation (GO:0006165)2.81966456
116cilium organization (GO:0044782)2.80981272
117regulation of cilium assembly (GO:1902017)2.79849095
118axoneme assembly (GO:0035082)2.79838439
119somite rostral/caudal axis specification (GO:0032525)2.75757340
120positive regulation of guanylate cyclase activity (GO:0031284)2.75250043
121microtubule-based movement (GO:0007018)2.74119011
122tooth mineralization (GO:0034505)2.71893602
123cilium assembly (GO:0042384)2.71023006
124cilium morphogenesis (GO:0060271)2.70164451
125mitotic G1 DNA damage checkpoint (GO:0031571)2.69434996
126intraciliary transport (GO:0042073)2.64812680
127meiotic cell cycle process (GO:1903046)2.64198700
128cellular component assembly involved in morphogenesis (GO:0010927)2.64153071
129negative regulation of organelle assembly (GO:1902116)2.62515793
130mitochondrion degradation (GO:0000422)2.61700175
131peptidyl-glutamic acid modification (GO:0018200)2.58821397
132chromatin silencing (GO:0006342)2.54258794
133positive regulation of glycolytic process (GO:0045821)2.46232467
134synapsis (GO:0007129)2.45780331
135regulation of response to osmotic stress (GO:0047484)2.44793013
136GTP biosynthetic process (GO:0006183)2.43429264
137lactate metabolic process (GO:0006089)2.42751954
138sperm motility (GO:0030317)14.3371991
139fusion of sperm to egg plasma membrane (GO:0007342)13.2121987
140cell wall macromolecule metabolic process (GO:0044036)12.7036295
141cell wall macromolecule catabolic process (GO:0016998)12.7036295
142acrosome reaction (GO:0007340)12.6724544
143sperm-egg recognition (GO:0035036)11.4744515
144acrosome assembly (GO:0001675)11.1563952
145multicellular organism reproduction (GO:0032504)10.5358680
146binding of sperm to zona pellucida (GO:0007339)10.4197140
147cell-cell recognition (GO:0009988)10.2490778
148epithelial cilium movement (GO:0003351)10.0813031
149plasma membrane fusion (GO:0045026)10.0353252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.88107803
2EZH2_22144423_ChIP-Seq_EOC_Human4.36548451
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.18078883
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.88421200
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.77391859
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.29870020
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.11103127
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.83696628
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.78718574
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.49676402
11VDR_22108803_ChIP-Seq_LS180_Human2.49356480
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16802095
13* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.11687236
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.10243086
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10191060
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.09567459
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02355977
18DROSHA_22980978_ChIP-Seq_HELA_Human2.01894679
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98338025
20ZNF274_21170338_ChIP-Seq_K562_Hela1.98003845
21ERA_21632823_ChIP-Seq_H3396_Human1.90658734
22FUS_26573619_Chip-Seq_HEK293_Human1.88500921
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78855019
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.77474069
25RAC3_21632823_ChIP-Seq_H3396_Human1.77118665
26EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.75993834
27FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74573925
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.73727694
29MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.72884936
30KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.71340216
31STAT1_17558387_ChIP-Seq_HELA_Human1.71025479
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70391963
33SOX2_22085726_ChIP-Seq_NPCs_Mouse1.68295248
34TAF2_19829295_ChIP-Seq_ESCs_Human1.65844503
35TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.65814979
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65738702
37ER_23166858_ChIP-Seq_MCF-7_Human1.62825487
38* CTCF_27219007_Chip-Seq_Bcells_Human1.61703182
39WDR5_24793694_ChIP-Seq_LNCAP_Human1.61701188
40TDRD3_21172665_ChIP-Seq_MCF-7_Human1.61507172
41BCL6_27268052_Chip-Seq_Bcells_Human1.57754244
42GATA3_21867929_ChIP-Seq_CD8_Mouse1.53254417
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.52671278
44FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51354155
45E2F1_20622854_ChIP-Seq_HELA_Human1.49467924
46GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.49265277
47AR_25329375_ChIP-Seq_VCAP_Human1.48180680
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47473189
49SMC4_20622854_ChIP-Seq_HELA_Human1.47214319
50PHF8_20622854_ChIP-Seq_HELA_Human1.47021613
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.46866026
52REST_21632747_ChIP-Seq_MESCs_Mouse1.43092605
53OCT4_20526341_ChIP-Seq_ESCs_Human1.42042195
54KDM2B_26808549_Chip-Seq_REH_Human1.40894564
55TP63_22573176_ChIP-Seq_HFKS_Human1.39666953
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39324402
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38607244
58CBP_20019798_ChIP-Seq_JUKART_Human1.38607244
59P68_20966046_ChIP-Seq_HELA_Human1.38358607
60TAL1_26923725_Chip-Seq_HPCs_Mouse1.38170565
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36055578
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35267239
63CBX2_22325352_ChIP-Seq_293T-Rex_Human1.34768468
64HNFA_21074721_ChIP-Seq_CACO-2_Human1.34419504
65LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33998701
66RBPJ_21746931_ChIP-Seq_IB4_Human1.33162780
67TP53_18474530_ChIP-ChIP_U2OS_Human1.32977231
68CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.32222801
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32060937
70P300_27268052_Chip-Seq_Bcells_Human1.31812792
71RAD21_21589869_ChIP-Seq_MESCs_Mouse1.31162704
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.29781973
73P300_19829295_ChIP-Seq_ESCs_Human1.29193733
74ETV1_20927104_ChIP-Seq_GIST48_Human1.28852318
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.28507840
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28116686
77* P53_21459846_ChIP-Seq_SAOS-2_Human1.28067411
78SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28030044
79* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27920712
80CEBPB_22108803_ChIP-Seq_LS180_Human1.27470792
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.27341597
82KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.27101006
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26859708
84* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25494620
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25141347
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25092470
87LXR_22292898_ChIP-Seq_THP-1_Human1.24440282
88GF1_26923725_Chip-Seq_HPCs_Mouse1.21415122
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21010051
90GATA3_21878914_ChIP-Seq_MCF-7_Human1.20681957
91* GATA3_21867929_ChIP-Seq_TH1_Mouse1.19789844
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19572137
93CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18906555
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18836900
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18836900
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18809924
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18693618
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18615333
99* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.18464481
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17818078
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.17572879
102MYC_27129775_Chip-Seq_CORNEA_Mouse1.17044776
103SPI1_26923725_Chip-Seq_HPCs_Mouse1.16842978
104CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16672621
105SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16238513
106SMRT_27268052_Chip-Seq_Bcells_Human1.14915125
107PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14535500
108* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.13790360
109RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13452188
110SMAD4_21741376_ChIP-Seq_HESCs_Human1.13368278
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12190328
112PHF8_20622853_ChIP-Seq_HELA_Human1.11381817
113RUNX_20019798_ChIP-Seq_JUKART_Human1.10990295
114PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09889830
115* EZH2_27294783_Chip-Seq_ESCs_Mouse1.09595442
116* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09433578
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09082120
118* NFE2_27457419_Chip-Seq_LIVER_Mouse1.08793476
119ERG_20517297_ChIP-Seq_VCAP_Human1.08625703
120GATA6_21074721_ChIP-Seq_CACO-2_Human1.08547402
121* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08357548
122CTCF_20526341_ChIP-Seq_ESCs_Human1.08069200
123SMAD4_21799915_ChIP-Seq_A2780_Human1.07532621
124YY1_22570637_ChIP-Seq_MALME-3M_Human1.06855756
125SA1_27219007_Chip-Seq_Bcells_Human1.06326426
126RUNX2_22187159_ChIP-Seq_PCA_Human1.06062241
127JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05997938
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05890668
129TET1_21451524_ChIP-Seq_MESCs_Mouse1.05719994
130RARA_24833708_ChIP-Seq_LIVER_Mouse1.05643463
131GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05157676
132NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05128558
133OCT1_27270436_Chip-Seq_PROSTATE_Human1.05028093
134RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04270728
135NFYA_21822215_ChIP-Seq_K562_Human1.04156378
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03600293
137NANOG_19829295_ChIP-Seq_ESCs_Human1.02549846
138SOX2_19829295_ChIP-Seq_ESCs_Human1.02549846
139* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00864620
140ELF1_20517297_ChIP-Seq_JURKAT_Human1.00554002
141ESET_19884257_ChIP-Seq_ESCs_Mouse1.00547776
142STAT3_23295773_ChIP-Seq_U87_Human0.99902696
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99388902
144FLI1_21867929_ChIP-Seq_CD8_Mouse0.97364740
145NFYB_21822215_ChIP-Seq_K562_Human0.96792804
146* CRX_20693478_ChIP-Seq_RETINA_Mouse0.96228236
147* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94600788
148TAF15_26573619_Chip-Seq_HEK293_Human0.93741386
149* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93639399
150* NANOG_18555785_Chip-Seq_ESCs_Mouse0.92846808
151TBL1_22424771_ChIP-Seq_293T_Human0.92263006
152BCOR_27268052_Chip-Seq_Bcells_Human0.92148508
153* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92125577
154NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.91905741
155SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91580760
156LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90731574
157NANOG_20526341_ChIP-Seq_ESCs_Human0.90598555
158SOX2_21211035_ChIP-Seq_LN229_Human0.90392622
159* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.89913196
160* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89558623
161TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88805346
162SMAD3_21741376_ChIP-Seq_ESCs_Human0.87943036
163STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87408163
164PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87178340
165SMAD4_21741376_ChIP-Seq_EPCs_Human0.85936376
166MYC_19829295_ChIP-Seq_ESCs_Human0.85722800

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.00016290
2MP0001929_abnormal_gametogenesis5.37419450
3MP0008877_abnormal_DNA_methylation3.54133461
4MP0002161_abnormal_fertility/fecundity3.26364099
5MP0002210_abnormal_sex_determination3.21800268
6MP0001348_abnormal_lacrimal_gland3.18028698
7MP0005670_abnormal_white_adipose3.06291158
8MP0001145_abnormal_male_reproductive2.73353178
9MP0000678_abnormal_parathyroid_gland2.44063935
10MP0000653_abnormal_sex_gland2.36541846
11MP0002653_abnormal_ependyma_morphology2.33437080
12MP0003718_maternal_effect2.27221501
13MP0005410_abnormal_fertilization16.6537303
14MP0003646_muscle_fatigue1.92198297
15MP0002132_abnormal_respiratory_system1.79400886
16MP0004233_abnormal_muscle_weight1.65426926
17MP0005379_endocrine/exocrine_gland_phen1.60100254
18MP0001485_abnormal_pinna_reflex1.57275422
19MP0005310_abnormal_salivary_gland1.55579090
20MP0002249_abnormal_larynx_morphology1.51838717
21MP0002160_abnormal_reproductive_system1.45130387
22MP0009053_abnormal_anal_canal1.39100828
23MP0005623_abnormal_meninges_morphology1.37423730
24MP0002822_catalepsy1.35863864
25MP0002282_abnormal_trachea_morphology1.29763454
26MP0002138_abnormal_hepatobiliary_system1.27414313
27MP0002735_abnormal_chemical_nociception1.21081091
28MP0004859_abnormal_synaptic_plasticity1.20499416
29MP0001963_abnormal_hearing_physiology1.11466370
30MP0001984_abnormal_olfaction1.09714150
31MP0001765_abnormal_ion_homeostasis1.08088074
32MP0004510_myositis1.06787329
33MP0002127_abnormal_cardiovascular_syste1.04677407
34MP0005451_abnormal_body_composition1.02561806
35MP0005395_other_phenotype1.01394206
36MP0000026_abnormal_inner_ear0.99932361
37MP0005647_abnormal_sex_gland0.92919176
38MP0000955_abnormal_spinal_cord0.90500290
39MP0003329_amyloid_beta_deposits0.88489650
40MP0005377_hearing/vestibular/ear_phenot0.87912547
41MP0003878_abnormal_ear_physiology0.87912547
42MP0005248_abnormal_Harderian_gland0.87610458
43MP0003011_delayed_dark_adaptation0.87598543
44MP0002067_abnormal_sensory_capabilities0.87375048
45MP0005083_abnormal_biliary_tract0.85061558
46MP0009046_muscle_twitch0.84936077
47MP0008995_early_reproductive_senescence0.81559674
48MP0003115_abnormal_respiratory_system0.78888096
49MP0002557_abnormal_social/conspecific_i0.78034382
50MP0000049_abnormal_middle_ear0.77837343
51MP0000681_abnormal_thyroid_gland0.73730396
52MP0002733_abnormal_thermal_nociception0.73439212
53MP0002234_abnormal_pharynx_morphology0.72427840
54MP0005389_reproductive_system_phenotype0.71374959
55MP0001905_abnormal_dopamine_level0.71019323
56MP0004085_abnormal_heartbeat0.68577214
57MP0002272_abnormal_nervous_system0.67704897
58MP0001879_abnormal_lymphatic_vessel0.67408971
59MP0009745_abnormal_behavioral_response0.66854088
60MP0005666_abnormal_adipose_tissue0.63905652
61MP0008058_abnormal_DNA_repair0.63149148
62MP0001666_abnormal_nutrient_absorption0.62369371
63MP0005367_renal/urinary_system_phenotyp0.61457935
64MP0000516_abnormal_urinary_system0.61457935
65MP0005636_abnormal_mineral_homeostasis0.58895427
66MP0004484_altered_response_of0.57331803
67MP0003137_abnormal_impulse_conducting0.55386465
68MP0005084_abnormal_gallbladder_morpholo0.54954218
69MP0001970_abnormal_pain_threshold0.54856909
70MP0005167_abnormal_blood-brain_barrier0.54309563
71MP0001501_abnormal_sleep_pattern0.54254285
72MP0002734_abnormal_mechanical_nocicepti0.51824706
73MP0004036_abnormal_muscle_relaxation0.51569588
74MP0002736_abnormal_nociception_after0.50836483
75MP0001324_abnormal_eye_pigmentation0.50472302
76MP0009278_abnormal_bone_marrow0.50345234
77MP0009697_abnormal_copulation0.48343495
78MP0003119_abnormal_digestive_system0.47749696
79MP0002269_muscular_atrophy0.47687920
80MP0005253_abnormal_eye_physiology0.47549269
81MP0000604_amyloidosis0.47532025
82MP0000534_abnormal_ureter_morphology0.47186752
83MP0001293_anophthalmia0.47099649
84MP0000613_abnormal_salivary_gland0.46274074
85MP0005551_abnormal_eye_electrophysiolog0.46233866
86MP0003699_abnormal_female_reproductive0.46208296
87MP0005535_abnormal_body_temperature0.45777814
88MP0005645_abnormal_hypothalamus_physiol0.45763225
89MP0003635_abnormal_synaptic_transmissio0.45393672
90MP0000249_abnormal_blood_vessel0.45101236
91MP0009115_abnormal_fat_cell0.44021318
92MP0001764_abnormal_homeostasis0.42702880
93MP0003880_abnormal_central_pattern0.42702081
94MP0006292_abnormal_olfactory_placode0.41481674
95MP0000358_abnormal_cell_content/0.41115442
96MP0000470_abnormal_stomach_morphology0.41030623
97MP0000230_abnormal_systemic_arterial0.40937765
98MP0000003_abnormal_adipose_tissue0.39888463
99MP0002971_abnormal_brown_adipose0.37723699
100MP0002882_abnormal_neuron_morphology0.37108061
101MP0000566_synostosis0.37000829
102MP0003942_abnormal_urinary_system0.36358426
103MP0005397_hematopoietic_system_phenotyp0.35845320
104MP0001545_abnormal_hematopoietic_system0.35845320
105MP0003077_abnormal_cell_cycle0.35430411
106MP0005391_vision/eye_phenotype0.34625407
107MP0002928_abnormal_bile_duct0.33941453
108MP0003633_abnormal_nervous_system0.33769925
109MP0002139_abnormal_hepatobiliary_system0.33748800
110MP0004019_abnormal_vitamin_homeostasis0.32782515
111MP0003950_abnormal_plasma_membrane0.32738281
112MP0001968_abnormal_touch/_nociception0.29521515
113MP0003631_nervous_system_phenotype0.28702309
114MP0006036_abnormal_mitochondrial_physio0.28476258
115MP0002295_abnormal_pulmonary_circulatio0.28417014
116MP0003948_abnormal_gas_homeostasis0.27605212
117MP0000569_abnormal_digit_pigmentation0.27553084
118MP0004133_heterotaxia0.27546596
119MP0002152_abnormal_brain_morphology0.27226237
120MP0003279_aneurysm0.27136841
121MP0000751_myopathy0.26707982
122MP0008569_lethality_at_weaning0.26044951
123MP0002254_reproductive_system_inflammat0.25982926
124MP0003861_abnormal_nervous_system0.25560730
125MP0001661_extended_life_span0.25523904
126MP0004811_abnormal_neuron_physiology0.25073487
127MP0001119_abnormal_female_reproductive0.24899284
128MP0002909_abnormal_adrenal_gland0.24785877
129MP0004270_analgesia0.23201196
130MP0005503_abnormal_tendon_morphology0.22131866
131MP0004742_abnormal_vestibular_system0.22114999
132MP0002102_abnormal_ear_morphology0.21982960
133MP0010094_abnormal_chromosome_stability0.21938590
134MP0003879_abnormal_hair_cell0.20705454
135MP0001440_abnormal_grooming_behavior0.20608351
136MP0005375_adipose_tissue_phenotype0.19916123
137MP0002108_abnormal_muscle_morphology0.18922261
138MP0002169_no_abnormal_phenotype0.18664925
139MP0002572_abnormal_emotion/affect_behav0.18496125
140MP0002873_normal_phenotype0.18361406
141MP0002092_abnormal_eye_morphology0.18079958
142MP0010329_abnormal_lipoprotein_level0.18038634
143MP0002118_abnormal_lipid_homeostasis0.17921475
144MP0005365_abnormal_bile_salt0.17633279
145MP0003936_abnormal_reproductive_system0.16783822
146MP0002229_neurodegeneration0.16608112
147MP0003959_abnormal_lean_body0.16413265
148MP0004130_abnormal_muscle_cell0.16396567
149MP0001270_distended_abdomen0.16289521
150MP0005423_abnormal_somatic_nervous0.16147896
151MP0005195_abnormal_posterior_eye0.15684251
152MP0008961_abnormal_basal_metabolism0.15678114
153MP0003632_abnormal_nervous_system0.15353311
154MP0001486_abnormal_startle_reflex0.15324457
155MP0003634_abnormal_glial_cell0.14413764
156MP0000462_abnormal_digestive_system0.14277593
157MP0001986_abnormal_taste_sensitivity0.14033337

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.22293680
2Abnormal respiratory motile cilium morphology (HP:0005938)9.22293680
3Abnormal respiratory motile cilium physiology (HP:0012261)9.10865853
4Severe visual impairment (HP:0001141)8.25888307
5Rhinitis (HP:0012384)7.40672139
6Infertility (HP:0000789)7.05941871
7Abnormal ciliary motility (HP:0012262)7.04786737
8Chronic bronchitis (HP:0004469)7.01488519
9Nasal polyposis (HP:0100582)6.19028374
10Chronic hepatic failure (HP:0100626)5.09522610
11Abnormality of the nasal mucosa (HP:0000433)5.06792784
12Attenuation of retinal blood vessels (HP:0007843)5.00142589
13Bony spicule pigmentary retinopathy (HP:0007737)4.99949753
14Male infertility (HP:0003251)4.87828736
15Hyperkalemia (HP:0002153)4.64077667
16Bronchitis (HP:0012387)4.49026044
17Bronchiectasis (HP:0002110)4.35963382
18Abnormality of macular pigmentation (HP:0008002)4.34743294
19Resting tremor (HP:0002322)4.30373666
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.29484240
21Nephronophthisis (HP:0000090)4.19831499
22Potter facies (HP:0002009)3.98215597
23Facial shape deformation (HP:0011334)3.98215597
24Abnormal rod and cone electroretinograms (HP:0008323)3.94719044
25Cone-rod dystrophy (HP:0000548)3.80947757
26Abnormal spermatogenesis (HP:0008669)3.64855438
27Aplasia/Hypoplasia of the earlobes (HP:0009906)3.58903712
28Hypoplastic ischia (HP:0003175)3.46961575
29Hypoplasia of the thymus (HP:0000778)3.34897148
30Recurrent otitis media (HP:0000403)3.32139872
31Progressive sensorineural hearing impairment (HP:0000408)3.26386066
32Hypoalphalipoproteinemia (HP:0003233)3.18345119
33Abnormality of the renal medulla (HP:0100957)3.16195053
34Enlarged epiphyses (HP:0010580)3.15507527
35Postural instability (HP:0002172)3.12501645
36Progressive cerebellar ataxia (HP:0002073)3.11873864
37Abnormality of the ischium (HP:0003174)3.09838230
38Recurrent sinusitis (HP:0011108)3.03636752
39Unilateral renal agenesis (HP:0000122)3.01311370
40Impulsivity (HP:0100710)3.00117883
41Amelogenesis imperfecta (HP:0000705)2.91204726
42Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.89364743
43Tubulointerstitial nephritis (HP:0001970)2.84778346
44Abnormality of the aortic arch (HP:0012303)2.83283496
45Recurrent bronchitis (HP:0002837)2.80717727
46Generalized aminoaciduria (HP:0002909)2.79591702
47Renovascular hypertension (HP:0100817)2.73840541
48Menstrual irregularities (HP:0000858)2.71369363
49Abnormality of potassium homeostasis (HP:0011042)2.63440256
50Tubular atrophy (HP:0000092)2.60005119
51Portal hypertension (HP:0001409)2.57821507
52Insulin-resistant diabetes mellitus (HP:0000831)2.55771493
53Abnormality of dental color (HP:0011073)2.54038778
54Cholecystitis (HP:0001082)2.51785719
55Abnormal gallbladder physiology (HP:0012438)2.51785719
56Abnormality of the hepatic vasculature (HP:0006707)2.49293234
57Abnormality of the costochondral junction (HP:0000919)2.45429914
58Tubulointerstitial abnormality (HP:0001969)2.45202784
59Abnormality of the parathyroid morphology (HP:0011766)2.43536261
60Gonadotropin excess (HP:0000837)2.43317867
61Molar tooth sign on MRI (HP:0002419)2.37635095
62Abnormality of midbrain morphology (HP:0002418)2.37635095
63Azoospermia (HP:0000027)2.29369056
64Dyschromatopsia (HP:0007641)2.26618068
65Medial flaring of the eyebrow (HP:0010747)2.25367124
66Choroideremia (HP:0001139)2.22925076
67Ventricular tachycardia (HP:0004756)2.19655337
68Spastic tetraparesis (HP:0001285)2.17990906
69Myokymia (HP:0002411)2.14676018
70Neurofibrillary tangles (HP:0002185)2.13347586
71Hypophosphatemic rickets (HP:0004912)2.12003386
72Tetany (HP:0001281)2.04960805
73Osteomalacia (HP:0002749)2.04111356
74Progressive hearing impairment (HP:0001730)2.02800785
75Decreased central vision (HP:0007663)2.01959794
76Absent/shortened dynein arms (HP:0200106)13.3164225
77Dynein arm defect of respiratory motile cilia (HP:0012255)13.3164225
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8450928
79Tubulointerstitial fibrosis (HP:0005576)1.98873703
80Abnormality of dentin (HP:0010299)1.98806983
81Optic nerve hypoplasia (HP:0000609)1.98053743
82Widely patent fontanelles and sutures (HP:0004492)1.96973580
83Recurrent pneumonia (HP:0006532)1.96172698
84Epiphyseal dysplasia (HP:0002656)1.95210635
85Hyperthyroidism (HP:0000836)1.94509672
86Increased purine levels (HP:0004368)1.93458327
87Hyperuricemia (HP:0002149)1.93458327
88Hyponatremia (HP:0002902)1.91692973
89Heterotopia (HP:0002282)1.90724978
90Flattened epiphyses (HP:0003071)1.88784024
91Renal Fanconi syndrome (HP:0001994)1.86288107
92Abnormality of the pubic bones (HP:0003172)1.84714848
93Hemorrhage of the eye (HP:0011885)1.84193693
94Intellectual disability, moderate (HP:0002342)1.81746173
95Bile duct proliferation (HP:0001408)1.81693279
96Abnormal biliary tract physiology (HP:0012439)1.81693279
97Recurrent corneal erosions (HP:0000495)1.80801228
98Abnormality of the epiphysis of the femoral head (HP:0010574)1.80658923
99Polydipsia (HP:0001959)1.79655498
100Abnormal drinking behavior (HP:0030082)1.79655498
101Pendular nystagmus (HP:0012043)1.79500828
102Postaxial foot polydactyly (HP:0001830)1.79033424
103Stage 5 chronic kidney disease (HP:0003774)1.77098394
104Bell-shaped thorax (HP:0001591)1.76900647
105Abnormality of the dental pulp (HP:0006479)1.76079871
106Abnormal ventriculo-arterial connection (HP:0011563)1.75113531
107Transposition of the great arteries (HP:0001669)1.75113531
108Abnormal connection of the cardiac segments (HP:0011545)1.75113531
109Bradycardia (HP:0001662)1.74197556
110Subcapsular cataract (HP:0000523)1.73427362
111Focal segmental glomerulosclerosis (HP:0000097)1.73046291
112Photophobia (HP:0000613)1.72049010
113Abnormality of chloride homeostasis (HP:0011422)1.70788495
114Short ribs (HP:0000773)1.70742882
115Cerebral inclusion bodies (HP:0100314)1.69775061
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69212081
117Hypoparathyroidism (HP:0000829)1.68671800
118Congenital hepatic fibrosis (HP:0002612)1.67533157
119Upper limb muscle weakness (HP:0003484)1.67141676
120Abnormality of renal excretion (HP:0011036)1.63761986
121Hemiparesis (HP:0001269)1.60588817
122Abnormality of the renal cortex (HP:0011035)1.59608887
123Decreased electroretinogram (ERG) amplitude (HP:0000654)1.56747733
124Abnormality of the dental root (HP:0006486)1.56677456
125Taurodontia (HP:0000679)1.56677456
126Abnormality of permanent molar morphology (HP:0011071)1.56677456
127Asymmetric septal hypertrophy (HP:0001670)1.54977981
128Renal dysplasia (HP:0000110)1.53153408
129Aplasia/Hypoplasia of the lens (HP:0008063)1.52333168
130Abnormality of molar (HP:0011077)1.45269650
131Abnormality of molar morphology (HP:0011070)1.45269650
132Easy fatigability (HP:0003388)1.44751745
133Deformed sella turcica (HP:0002681)1.44455524
134Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.44300622
135Absent epiphyses (HP:0010577)1.44300622
136Double outlet right ventricle (HP:0001719)1.43567627
137Congenital malformation of the right heart (HP:0011723)1.43567627
138Postaxial hand polydactyly (HP:0001162)1.43320100
139Abnormal urine output (HP:0012590)1.43180395
140Short femoral neck (HP:0100864)1.39612885
141Oculomotor apraxia (HP:0000657)1.38635274
142Fibular hypoplasia (HP:0003038)1.37081637
143Hypercholesterolemia (HP:0003124)1.36831206
144Exercise-induced myalgia (HP:0003738)1.35840299
145Cystic liver disease (HP:0006706)1.34343522
146Abnormality of the neuromuscular junction (HP:0003398)1.33214889
147Fatigable weakness (HP:0003473)1.33214889
148Bundle branch block (HP:0011710)1.30639431
149Loss of speech (HP:0002371)1.28112006
150Chronic sinusitis (HP:0011109)1.25095748
151Abnormality of the lower motor neuron (HP:0002366)1.25003113
152Short thorax (HP:0010306)1.23867039
153Nephropathy (HP:0000112)1.23761661
154Sensory axonal neuropathy (HP:0003390)1.23589349
155Clumsiness (HP:0002312)1.22294670
156Truncal obesity (HP:0001956)1.21492473
157Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.21247484
158Broad distal phalanx of finger (HP:0009836)1.20205609
159Myoglobinuria (HP:0002913)1.19876450
160Gait imbalance (HP:0002141)1.18909346
161Congenital primary aphakia (HP:0007707)1.18707649
162Absent frontal sinuses (HP:0002688)1.18037360
163Facial cleft (HP:0002006)1.16996048
164Polyuria (HP:0000103)1.15813693
165J-shaped sella turcica (HP:0002680)1.14492367
166Neoplasm of the heart (HP:0100544)1.14308504

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.49689241
2PDK47.49689241
3TESK16.92614037
4PRKD35.86714023
5ICK5.09421290
6PDK24.84177176
7INSRR3.55487973
8PLK23.08032753
9MAP4K23.04044463
10BRD43.01492588
11PTK2B2.27433055
12WNK42.19917349
13STK392.02642683
14PNCK1.99040784
15STK381.95122971
16DYRK1B1.79985922
17PIK3CG1.56594377
18MST1R1.56368562
19NEK21.52573643
20PDK11.21617365
21CDK121.20436809
22CDK71.15603278
23TYRO31.02920466
24SIK20.93602264
25MAPK150.93258445
26IRAK10.90431038
27MAP3K90.88684330
28AKT30.88247795
29CAMK1D0.87621634
30WNK10.87220275
31LMTK20.86103244
32KSR20.84537907
33PDPK10.82908440
34DYRK30.82730181
35RPS6KA20.75764226
36UHMK10.73975061
37MUSK0.73508934
38PINK10.72580221
39NTRK20.72542291
40LATS20.69589130
41RIPK40.68512408
42CAMK1G0.68267411
43MAP3K110.66552277
44ROCK10.62190200
45MAP2K20.61745463
46ARAF0.60906630
47CAMK10.60603237
48BMPR1B0.59509895
49STK30.58843497
50MARK10.57938205
51CHEK20.57326543
52EEF2K0.56748900
53PRKAA20.56571332
54TESK20.55906756
55PASK0.55292443
56IRAK20.54627389
57MAP3K20.54496837
58SGK4940.51865255
59SGK2230.51865255
60MAP2K60.50935652
61CCNB10.50183061
62TTK0.47630033
63CDK30.47485862
64NTRK30.47075337
65MAP3K80.46930917
66OXSR10.42968047
67MAPK10.41204504
68RPS6KC10.41183950
69RPS6KL10.41183950
70RPS6KA60.41033411
71CAMK40.40971539
72LATS10.39256692
73PRKCG0.38733142
74PAK10.38307140
75FRK0.37699807
76NEK60.36948457
77TIE10.35851485
78CHEK10.32975670
79PAK20.32363818
80SGK10.31633952
81MTOR0.28316129
82STK38L0.28289732
83MARK20.27196993
84PAK40.25768090
85PRKAA10.25371435
86MAPK140.25354884
87ADRBK20.24112696
88MAP3K10.23712754
89ACVR1B0.23065190
90MAPK100.22267120
91ATM0.22052858
92CAMKK10.21877061
93MET0.21687913
94MAP3K100.21643078
95RPS6KB10.21484603
96PRKCZ0.20580739
97MAPKAPK50.19995524
98PRKCQ0.19976815
99AKT10.18711448
100ATR0.17975226
101ZAK0.17247692
102SGK20.16816948
103PHKG20.16294356
104PHKG10.16294356
105MAPK110.15034934
106TRIB30.14691623
107TNIK0.14105200
108CDK150.13806360
109TLK10.13308339
110FER0.13049771
111PRKG20.11408769
112RPS6KA10.10905885
113CDK180.10807911
114VRK10.10587960
115CDK11A0.10381918
116PRKCE0.09966069
117DDR20.09057523
118CDK60.09031253
119GSK3B0.08289114
120WNK30.07888461
121EPHB10.06844571
122CAMK2A0.06318330
123CDK140.05358490
124PLK40.05175325
125PLK10.04769214
126PRKACG0.04323044
127CSNK2A10.03926283
128PRKG10.03285548
129CSF1R0.02732005
130STK100.02651340
131PRKCD0.02315374
132PRKCA0.02157202
133PKN10.02134286
134STK110.01834477
135PRKCB0.01610919
136YES10.01566798
137PIM10.01529118
138EGFR0.00970991
139CSNK1D0.00671624
140MAPK80.00305155
141BRAF0.00091833
142EPHA4-0.0258344
143BRSK2-0.0254895
144PRKACB-0.0249929
145MAP3K4-0.0226441
146CDC7-0.0210341
147PAK6-0.0186131
148PRKACA-0.0175508
149PDGFRB-0.0140069
150RPS6KA3-0.0095719
151WEE1-0.0043072
152CLK1-0.0038993
153CDK2-0.0022981
154CDK4-0.0019896
155CDK1-0.0004718

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.53587743
2Fatty acid biosynthesis_Homo sapiens_hsa000615.48579434
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.27597824
4Olfactory transduction_Homo sapiens_hsa047403.48768151
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.26194019
6Pyruvate metabolism_Homo sapiens_hsa006203.05879247
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.05479134
8Linoleic acid metabolism_Homo sapiens_hsa005913.01027634
9Vitamin B6 metabolism_Homo sapiens_hsa007502.82932727
10Butanoate metabolism_Homo sapiens_hsa006502.69865423
11Propanoate metabolism_Homo sapiens_hsa006402.51565620
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.43949967
13Glucagon signaling pathway_Homo sapiens_hsa049222.42023942
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.31963189
15PPAR signaling pathway_Homo sapiens_hsa033202.11471654
16Glycerolipid metabolism_Homo sapiens_hsa005611.97925457
17Fatty acid metabolism_Homo sapiens_hsa012121.93938348
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.90822508
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.89681321
20Fatty acid degradation_Homo sapiens_hsa000711.81523679
21Basal transcription factors_Homo sapiens_hsa030221.81381910
22Selenocompound metabolism_Homo sapiens_hsa004501.78034910
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.77644079
24Fructose and mannose metabolism_Homo sapiens_hsa000511.75344369
25Mineral absorption_Homo sapiens_hsa049781.62567560
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.60833884
27Type II diabetes mellitus_Homo sapiens_hsa049301.60612336
28Dorso-ventral axis formation_Homo sapiens_hsa043201.54051638
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52511282
30Type I diabetes mellitus_Homo sapiens_hsa049401.49949473
31Fat digestion and absorption_Homo sapiens_hsa049751.48833238
32Ether lipid metabolism_Homo sapiens_hsa005651.46502062
33Amphetamine addiction_Homo sapiens_hsa050311.45367980
34Oocyte meiosis_Homo sapiens_hsa041141.40866928
35Allograft rejection_Homo sapiens_hsa053301.38100037
36Autoimmune thyroid disease_Homo sapiens_hsa053201.36605043
37Phenylalanine metabolism_Homo sapiens_hsa003601.35329132
38Phototransduction_Homo sapiens_hsa047441.28579611
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.27947134
40Carbon metabolism_Homo sapiens_hsa012001.27529157
41Pentose phosphate pathway_Homo sapiens_hsa000301.26699556
42Graft-versus-host disease_Homo sapiens_hsa053321.25999016
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20278850
44Cardiac muscle contraction_Homo sapiens_hsa042601.20164162
45Arginine and proline metabolism_Homo sapiens_hsa003301.19293870
46Fanconi anemia pathway_Homo sapiens_hsa034601.14707911
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.10520122
48Hedgehog signaling pathway_Homo sapiens_hsa043401.10344309
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07950846
50Morphine addiction_Homo sapiens_hsa050321.04941810
51Glutathione metabolism_Homo sapiens_hsa004800.98854940
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.98527195
53Nicotine addiction_Homo sapiens_hsa050330.98104441
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.97489549
55Renin secretion_Homo sapiens_hsa049240.97093987
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92776334
57Viral myocarditis_Homo sapiens_hsa054160.92704059
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92374539
59Insulin secretion_Homo sapiens_hsa049110.91056144
60Arachidonic acid metabolism_Homo sapiens_hsa005900.90183662
61Antigen processing and presentation_Homo sapiens_hsa046120.88093515
62Biosynthesis of amino acids_Homo sapiens_hsa012300.84559395
63Bile secretion_Homo sapiens_hsa049760.83985465
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82932993
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82468707
66Purine metabolism_Homo sapiens_hsa002300.80176245
67mRNA surveillance pathway_Homo sapiens_hsa030150.79560357
68Arginine biosynthesis_Homo sapiens_hsa002200.78956229
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.78051135
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77804872
71Thyroid hormone synthesis_Homo sapiens_hsa049180.74639656
72Chemical carcinogenesis_Homo sapiens_hsa052040.73185506
73Estrogen signaling pathway_Homo sapiens_hsa049150.72785175
74Collecting duct acid secretion_Homo sapiens_hsa049660.72079480
75Huntingtons disease_Homo sapiens_hsa050160.71539660
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65815924
77Long-term potentiation_Homo sapiens_hsa047200.65584220
78Tyrosine metabolism_Homo sapiens_hsa003500.63820684
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63268382
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62771326
81ABC transporters_Homo sapiens_hsa020100.62508662
82Salivary secretion_Homo sapiens_hsa049700.62307219
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59034092
84Influenza A_Homo sapiens_hsa051640.58730292
85Calcium signaling pathway_Homo sapiens_hsa040200.57880105
86Retinol metabolism_Homo sapiens_hsa008300.57680216
87Protein digestion and absorption_Homo sapiens_hsa049740.55849219
88Pancreatic secretion_Homo sapiens_hsa049720.55647419
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.54193152
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52155354
91Legionellosis_Homo sapiens_hsa051340.51977041
92Serotonergic synapse_Homo sapiens_hsa047260.51708836
93MAPK signaling pathway_Homo sapiens_hsa040100.50196395
94RNA transport_Homo sapiens_hsa030130.49188106
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47352834
96Gastric acid secretion_Homo sapiens_hsa049710.47291722
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46130938
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.46121128
99Sulfur metabolism_Homo sapiens_hsa009200.45509711
100Tight junction_Homo sapiens_hsa045300.45069741
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44845669
102AMPK signaling pathway_Homo sapiens_hsa041520.44008926
103GABAergic synapse_Homo sapiens_hsa047270.41519804
104Nitrogen metabolism_Homo sapiens_hsa009100.40367727
105Cholinergic synapse_Homo sapiens_hsa047250.40171625
106Renin-angiotensin system_Homo sapiens_hsa046140.40075909
107Endocytosis_Homo sapiens_hsa041440.39731922
108Synaptic vesicle cycle_Homo sapiens_hsa047210.37599304
109cAMP signaling pathway_Homo sapiens_hsa040240.37200819
110Metabolic pathways_Homo sapiens_hsa011000.36677953
111Taste transduction_Homo sapiens_hsa047420.36545198
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36455196
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35662759
114Cocaine addiction_Homo sapiens_hsa050300.34830541
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34159861
116Systemic lupus erythematosus_Homo sapiens_hsa053220.34052221
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33029806
118Inositol phosphate metabolism_Homo sapiens_hsa005620.32872382
119Acute myeloid leukemia_Homo sapiens_hsa052210.32097736
120Basal cell carcinoma_Homo sapiens_hsa052170.31643568
121Oxytocin signaling pathway_Homo sapiens_hsa049210.29708439
122Circadian entrainment_Homo sapiens_hsa047130.29234035
123VEGF signaling pathway_Homo sapiens_hsa043700.28469709
124Viral carcinogenesis_Homo sapiens_hsa052030.22015280
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.21096743
126Alcoholism_Homo sapiens_hsa050340.20722374
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20155308
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19210785
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.19201367
130Peroxisome_Homo sapiens_hsa041460.17592996
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17554753
132Sphingolipid metabolism_Homo sapiens_hsa006000.16153487
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15925739
134Wnt signaling pathway_Homo sapiens_hsa043100.15063631
135Glutamatergic synapse_Homo sapiens_hsa047240.13605228
136Insulin resistance_Homo sapiens_hsa049310.11788888
137HIF-1 signaling pathway_Homo sapiens_hsa040660.08181296
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.06374307

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