SPATA31A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.28435025
2DNA packaging (GO:0006323)8.87114773
3sperm capacitation (GO:0048240)8.69521673
4microtubule depolymerization (GO:0007019)8.50327496
5plasma membrane fusion (GO:0045026)8.49798540
6protein targeting to Golgi (GO:0000042)8.43875663
7establishment of protein localization to Golgi (GO:0072600)8.10247413
8spermatid development (GO:0007286)7.99844205
9retrograde transport, vesicle recycling within Golgi (GO:0000301)7.88095399
10protein polyglutamylation (GO:0018095)7.62673588
11single strand break repair (GO:0000012)7.56062155
12microtubule polymerization or depolymerization (GO:0031109)7.51793844
13rRNA methylation (GO:0031167)7.38295112
14sperm-egg recognition (GO:0035036)7.33977084
15response to pheromone (GO:0019236)7.30722704
16spermatid nucleus differentiation (GO:0007289)7.30055940
17multicellular organism reproduction (GO:0032504)6.96112963
18binding of sperm to zona pellucida (GO:0007339)6.71597909
19centriole replication (GO:0007099)6.60105040
20reproduction (GO:0000003)6.47879196
21calcium ion-dependent exocytosis (GO:0017156)6.47795550
22* spermatogenesis (GO:0007283)6.33544025
23phosphatidylethanolamine biosynthetic process (GO:0006646)6.32921122
24* male gamete generation (GO:0048232)6.31409287
25rRNA modification (GO:0000154)6.20661076
26axonemal dynein complex assembly (GO:0070286)6.17383870
27protein localization to Golgi apparatus (GO:0034067)6.07715154
28sexual reproduction (GO:0019953)6.06525212
29cell-cell recognition (GO:0009988)6.04560441
30negative regulation of inclusion body assembly (GO:0090084)5.97703714
31phosphatidylethanolamine metabolic process (GO:0046337)5.84220083
32centriole assembly (GO:0098534)5.83630125
33* gamete generation (GO:0007276)5.79888308
34microtubule severing (GO:0051013)5.69511136
35regulation of centriole replication (GO:0046599)5.65891511
36seminiferous tubule development (GO:0072520)5.63028849
37single fertilization (GO:0007338)5.32814757
38motile cilium assembly (GO:0044458)5.10767028
39regulation of cilium movement (GO:0003352)5.06217786
40cilium or flagellum-dependent cell motility (GO:0001539)5.02234922
41RNA destabilization (GO:0050779)5.01298411
42regulation of Rab GTPase activity (GO:0032313)4.94542456
43positive regulation of Rab GTPase activity (GO:0032851)4.94542456
44glomerular visceral epithelial cell development (GO:0072015)4.81842425
45* multicellular organismal reproductive process (GO:0048609)4.63481199
46germ cell development (GO:0007281)4.61096118
47fertilization (GO:0009566)4.60914275
48cellular ketone body metabolic process (GO:0046950)4.57520204
49glomerular epithelial cell development (GO:0072310)4.51327231
50cell wall macromolecule catabolic process (GO:0016998)4.42213188
51epithelial cilium movement (GO:0003351)4.41227047
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.38194072
53nucleus organization (GO:0006997)4.24925656
54microtubule nucleation (GO:0007020)4.24258293
55regulation of inclusion body assembly (GO:0090083)4.24173159
56cell wall macromolecule metabolic process (GO:0044036)4.23532635
57regulation of transcription involved in cell fate commitment (GO:0060850)4.18178383
58multicellular organismal movement (GO:0050879)4.16357934
59musculoskeletal movement (GO:0050881)4.16357934
60ketone body metabolic process (GO:1902224)4.08584756
61chromatin silencing (GO:0006342)4.08284432
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.91618521
63cilium movement (GO:0003341)3.87054683
64glycerol ether metabolic process (GO:0006662)3.83657857
65nuclear pore complex assembly (GO:0051292)3.71653793
66ether metabolic process (GO:0018904)3.53584387
67membrane protein intracellular domain proteolysis (GO:0031293)3.49405872
68organic cation transport (GO:0015695)3.46724940
69coenzyme catabolic process (GO:0009109)3.29932071
70protein depolymerization (GO:0051261)3.26813217
71negative regulation of Rho protein signal transduction (GO:0035024)3.26080860
72intra-Golgi vesicle-mediated transport (GO:0006891)3.21424393
73regulation of microtubule-based movement (GO:0060632)3.19397794
74protein-DNA complex disassembly (GO:0032986)3.16588779
75nucleosome disassembly (GO:0006337)3.16588779
76cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.13461815
77polyamine biosynthetic process (GO:0006596)3.11953540
78cellular response to pH (GO:0071467)3.11283850
79histone H3-K9 demethylation (GO:0033169)3.10226915
80response to acidic pH (GO:0010447)3.10082283
81ventricular system development (GO:0021591)3.03243480
82multicellular organismal development (GO:0007275)3.02691162
83Golgi to endosome transport (GO:0006895)2.99775510
84regulation of interleukin-13 production (GO:0032656)2.98485954
85receptor recycling (GO:0001881)2.98261233
86homeostasis of number of cells within a tissue (GO:0048873)2.96880173
87cerebral cortex neuron differentiation (GO:0021895)2.92693925
88cell recognition (GO:0008037)2.92186497
89regulation of phosphoprotein phosphatase activity (GO:0043666)2.89939896
90DNA conformation change (GO:0071103)2.88784632
91centrosome duplication (GO:0051298)2.82813026
92mitotic G1 DNA damage checkpoint (GO:0031571)2.81958821
93pore complex assembly (GO:0046931)2.80791005
94regulation of ARF GTPase activity (GO:0032312)2.80263173
95positive regulation of guanylate cyclase activity (GO:0031284)2.79530546
96regulation of T-helper 2 cell differentiation (GO:0045628)2.75931389
97nuclear pore organization (GO:0006999)2.74921661
98sperm motility (GO:0030317)12.0951534
99acrosome reaction (GO:0007340)11.5766901
100fusion of sperm to egg plasma membrane (GO:0007342)11.2149949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.09932079
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.02615087
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.59976599
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80988776
5TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53856171
6POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.53856171
7CBP_20019798_ChIP-Seq_JUKART_Human2.31966477
8IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.31966477
9FUS_26573619_Chip-Seq_HEK293_Human2.22106903
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17275653
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14501397
12EZH2_22144423_ChIP-Seq_EOC_Human2.09888623
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.06898670
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05822283
15DROSHA_22980978_ChIP-Seq_HELA_Human1.92151218
16RAC3_21632823_ChIP-Seq_H3396_Human1.91520472
17ERA_21632823_ChIP-Seq_H3396_Human1.83955334
18ELF1_20517297_ChIP-Seq_JURKAT_Human1.80739253
19EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.74099720
20UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72968897
21WDR5_24793694_ChIP-Seq_LNCAP_Human1.72285431
22NANOG_20526341_ChIP-Seq_ESCs_Human1.69290269
23ER_23166858_ChIP-Seq_MCF-7_Human1.65806962
24MYC_19829295_ChIP-Seq_ESCs_Human1.65009051
25CTCF_27219007_Chip-Seq_Bcells_Human1.64903162
26EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.63550663
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63384738
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.62913853
29RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.61620329
30SMAD4_21741376_ChIP-Seq_EPCs_Human1.57550837
31TAF2_19829295_ChIP-Seq_ESCs_Human1.55512869
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54248179
33CBX2_22325352_ChIP-Seq_293T-Rex_Human1.51266351
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49896310
35SMC4_20622854_ChIP-Seq_HELA_Human1.49816656
36HNFA_21074721_ChIP-Seq_CACO-2_Human1.48998785
37BCL6_27268052_Chip-Seq_Bcells_Human1.48211154
38RBPJ_21746931_ChIP-Seq_IB4_Human1.47674391
39YY1_22570637_ChIP-Seq_MALME-3M_Human1.45048095
40CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.44605381
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.42576083
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.42470048
43OCT4_20526341_ChIP-Seq_ESCs_Human1.42465672
44TP53_18474530_ChIP-ChIP_U2OS_Human1.41887135
45TDRD3_21172665_ChIP-Seq_MCF-7_Human1.41381647
46ETV1_20927104_ChIP-Seq_GIST48_Human1.40701715
47CTCF_20526341_ChIP-Seq_ESCs_Human1.40394798
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.39461213
49AR_25329375_ChIP-Seq_VCAP_Human1.38533033
50TP63_22573176_ChIP-Seq_HFKS_Human1.37683628
51E2F1_20622854_ChIP-Seq_HELA_Human1.37129845
52BCOR_27268052_Chip-Seq_Bcells_Human1.36245208
53ERG_20517297_ChIP-Seq_VCAP_Human1.35726285
54P68_20966046_ChIP-Seq_HELA_Human1.35030838
55NFYB_21822215_ChIP-Seq_K562_Human1.34313108
56PHF8_20622854_ChIP-Seq_HELA_Human1.32821730
57P300_19829295_ChIP-Seq_ESCs_Human1.32154541
58TBL1_22424771_ChIP-Seq_293T_Human1.32080960
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32026111
60SMAD3_21741376_ChIP-Seq_ESCs_Human1.30269370
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29832121
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27990658
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26349221
64CEBPB_22108803_ChIP-Seq_LS180_Human1.25757242
65PHF8_20622853_ChIP-Seq_HELA_Human1.24787373
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20660231
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20547104
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.20248709
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19615366
70GATA6_21074721_ChIP-Seq_CACO-2_Human1.18973332
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18687547
72P300_27268052_Chip-Seq_Bcells_Human1.17757111
73SOX2_22085726_ChIP-Seq_NPCs_Mouse1.17457009
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.16708139
75LXR_22292898_ChIP-Seq_THP-1_Human1.16690490
76PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15021862
77P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.13364264
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12807734
79ZNF274_21170338_ChIP-Seq_K562_Hela1.12514729
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11941062
81NFYA_21822215_ChIP-Seq_K562_Human1.11832987
82GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.11680783
83KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.11560031
84SMAD4_21741376_ChIP-Seq_HESCs_Human1.10295741
85STAT3_23295773_ChIP-Seq_U87_Human1.08496058
86RUNX2_22187159_ChIP-Seq_PCA_Human1.07818368
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07688957
88P53_21459846_ChIP-Seq_SAOS-2_Human1.07316393
89SMAD4_21799915_ChIP-Seq_A2780_Human1.05948031
90SA1_27219007_Chip-Seq_Bcells_Human1.04555650
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03980327
92TAF15_26573619_Chip-Seq_HEK293_Human1.02909806
93RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01870789
94SOX2_19829295_ChIP-Seq_ESCs_Human1.01218661
95NANOG_19829295_ChIP-Seq_ESCs_Human1.01218661
96RUNX_20019798_ChIP-Seq_JUKART_Human1.01080199
97KLF5_25053715_ChIP-Seq_YYC3_Human1.00163977
98E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00091468
99SMRT_27268052_Chip-Seq_Bcells_Human0.99537518
100TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.99085348

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.96275906
2MP0003878_abnormal_ear_physiology5.96275906
3MP0005670_abnormal_white_adipose4.61965071
4MP0003698_abnormal_male_reproductive4.39074374
5MP0001929_abnormal_gametogenesis3.85453350
6MP0001348_abnormal_lacrimal_gland3.52859602
7MP0002161_abnormal_fertility/fecundity2.42420922
8MP0003646_muscle_fatigue2.28243216
9MP0003718_maternal_effect2.21787776
10MP0000678_abnormal_parathyroid_gland2.00294345
11MP0005410_abnormal_fertilization12.0025178
12MP0001485_abnormal_pinna_reflex1.98406848
13MP0005451_abnormal_body_composition1.96231318
14MP0003011_delayed_dark_adaptation1.87567046
15MP0005379_endocrine/exocrine_gland_phen1.79974193
16MP0002210_abnormal_sex_determination1.76075791
17MP0002132_abnormal_respiratory_system1.71074861
18MP0005310_abnormal_salivary_gland1.70423251
19MP0003879_abnormal_hair_cell1.67671113
20MP0001486_abnormal_startle_reflex1.67079081
21MP0005423_abnormal_somatic_nervous1.53144437
22MP0004742_abnormal_vestibular_system1.48902097
23MP0001145_abnormal_male_reproductive1.42280047
24MP0002282_abnormal_trachea_morphology1.34611620
25MP0000653_abnormal_sex_gland1.33428688
26MP0001963_abnormal_hearing_physiology1.22981613
27MP0004859_abnormal_synaptic_plasticity1.22567966
28MP0004510_myositis1.22208877
29MP0002249_abnormal_larynx_morphology1.22113138
30MP0001765_abnormal_ion_homeostasis1.19241734
31MP0002138_abnormal_hepatobiliary_system1.15181029
32MP0009053_abnormal_anal_canal1.12734674
33MP0002234_abnormal_pharynx_morphology1.12201890
34MP0000026_abnormal_inner_ear1.01534459
35MP0005395_other_phenotype0.99391412
36MP0009115_abnormal_fat_cell0.98173589
37MP0000534_abnormal_ureter_morphology0.98155797
38MP0002735_abnormal_chemical_nociception0.96244494
39MP0001968_abnormal_touch/_nociception0.96108327
40MP0005248_abnormal_Harderian_gland0.94546308
41MP0002822_catalepsy0.94262202
42MP0005551_abnormal_eye_electrophysiolog0.93228051
43MP0001984_abnormal_olfaction0.92424698
44MP0002127_abnormal_cardiovascular_syste0.91859066
45MP0002229_neurodegeneration0.87340704
46MP0005253_abnormal_eye_physiology0.86594437
47MP0008877_abnormal_DNA_methylation0.84540353
48MP0005666_abnormal_adipose_tissue0.81054485
49MP0009697_abnormal_copulation0.79650256
50MP0005083_abnormal_biliary_tract0.79355863
51MP0000955_abnormal_spinal_cord0.78362756
52MP0002067_abnormal_sensory_capabilities0.75467145
53MP0005167_abnormal_blood-brain_barrier0.75260467
54MP0004233_abnormal_muscle_weight0.67940707
55MP0008569_lethality_at_weaning0.67248227
56MP0008995_early_reproductive_senescence0.67077592
57MP0004085_abnormal_heartbeat0.66809159
58MP0005408_hypopigmentation0.64059861
59MP0002733_abnormal_thermal_nociception0.62195728
60MP0002557_abnormal_social/conspecific_i0.62188768
61MP0005636_abnormal_mineral_homeostasis0.60808003
62MP0005375_adipose_tissue_phenotype0.60086763
63MP0000681_abnormal_thyroid_gland0.59061228
64MP0001666_abnormal_nutrient_absorption0.58479848
65MP0002572_abnormal_emotion/affect_behav0.57038856
66MP0001905_abnormal_dopamine_level0.56462373
67MP0000049_abnormal_middle_ear0.53485216
68MP0000230_abnormal_systemic_arterial0.53197616
69MP0003077_abnormal_cell_cycle0.52819765
70MP0004036_abnormal_muscle_relaxation0.52355259
71MP0003137_abnormal_impulse_conducting0.51109393
72MP0002272_abnormal_nervous_system0.46896946
73MP0005367_renal/urinary_system_phenotyp0.45867019
74MP0000516_abnormal_urinary_system0.45867019
75MP0001440_abnormal_grooming_behavior0.45528844
76MP0004084_abnormal_cardiac_muscle0.44669598
77MP0000003_abnormal_adipose_tissue0.43883832
78MP0010329_abnormal_lipoprotein_level0.42692798
79MP0002928_abnormal_bile_duct0.42182291
80MP0005535_abnormal_body_temperature0.41940849
81MP0001501_abnormal_sleep_pattern0.41672131
82MP0004484_altered_response_of0.41111103
83MP0001970_abnormal_pain_threshold0.40296394
84MP0008961_abnormal_basal_metabolism0.40181540
85MP0005332_abnormal_amino_acid0.39880240
86MP0005391_vision/eye_phenotype0.38959142
87MP0009745_abnormal_behavioral_response0.38139298
88MP0002734_abnormal_mechanical_nocicepti0.37399956
89MP0001879_abnormal_lymphatic_vessel0.37240561
90MP0001545_abnormal_hematopoietic_system0.36544842
91MP0005397_hematopoietic_system_phenotyp0.36544842
92MP0005623_abnormal_meninges_morphology0.36298110
93MP0003631_nervous_system_phenotype0.36236254
94MP0001270_distended_abdomen0.35896666
95MP0004782_abnormal_surfactant_physiolog0.35319148
96MP0005595_abnormal_vascular_smooth0.34608757
97MP0002653_abnormal_ependyma_morphology0.31871004
98MP0005084_abnormal_gallbladder_morpholo0.31505413
99MP0000470_abnormal_stomach_morphology0.31401127
100MP0003699_abnormal_female_reproductive0.31055206

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.56247508
2Tubulointerstitial nephritis (HP:0001970)6.29927323
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.16801534
4Absent/shortened dynein arms (HP:0200106)6.16801534
5Asymmetric septal hypertrophy (HP:0001670)6.00237807
6Chronic hepatic failure (HP:0100626)5.95567933
7Resting tremor (HP:0002322)4.72931135
8Bony spicule pigmentary retinopathy (HP:0007737)4.60257622
9Attenuation of retinal blood vessels (HP:0007843)4.60089608
10Abnormal respiratory motile cilium physiology (HP:0012261)4.58698998
11Abnormal ciliary motility (HP:0012262)4.58507264
12Cone-rod dystrophy (HP:0000548)4.55854091
13Male infertility (HP:0003251)4.55606791
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.47508647
15Hyperkalemia (HP:0002153)4.47432840
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.42163507
17Nasal polyposis (HP:0100582)4.39557889
18Abnormality of macular pigmentation (HP:0008002)4.20191465
19Abnormal respiratory motile cilium morphology (HP:0005938)4.17408793
20Abnormal respiratory epithelium morphology (HP:0012253)4.17408793
21Infertility (HP:0000789)4.06798734
22Hypoalphalipoproteinemia (HP:0003233)3.82578342
23Aplasia/Hypoplasia of the earlobes (HP:0009906)3.77714430
24Progressive sensorineural hearing impairment (HP:0000408)3.76501064
25Bell-shaped thorax (HP:0001591)3.65718390
26Hypoplasia of the thymus (HP:0000778)3.60429566
27Abnormality of the nasal mucosa (HP:0000433)3.59043105
28Menstrual irregularities (HP:0000858)3.54669523
29Enlarged epiphyses (HP:0010580)3.47339062
30Impulsivity (HP:0100710)3.43076325
31Potter facies (HP:0002009)3.38954614
32Facial shape deformation (HP:0011334)3.38954614
33Amelogenesis imperfecta (HP:0000705)3.34817243
34Abnormality of dental color (HP:0011073)3.29381730
35Hypoplastic ischia (HP:0003175)3.25702744
36Renovascular hypertension (HP:0100817)3.24615055
37Abnormal rod and cone electroretinograms (HP:0008323)3.21273796
38Postural instability (HP:0002172)3.15749628
39Stage 5 chronic kidney disease (HP:0003774)3.05834835
40Truncal obesity (HP:0001956)3.05426449
41Insulin-resistant diabetes mellitus (HP:0000831)2.96833873
42Progressive cerebellar ataxia (HP:0002073)2.95008590
43Portal hypertension (HP:0001409)2.94123718
44Abnormality of the ischium (HP:0003174)2.92163343
45Abnormal spermatogenesis (HP:0008669)2.91943088
46Tubulointerstitial abnormality (HP:0001969)2.87249017
47Nephronophthisis (HP:0000090)2.71791115
48Abnormality of the hepatic vasculature (HP:0006707)2.70463737
49Rhinitis (HP:0012384)2.68580103
50Abnormality of the costochondral junction (HP:0000919)2.66937856
51Abnormal urine output (HP:0012590)2.51873982
52Focal segmental glomerulosclerosis (HP:0000097)2.51483059
53Azoospermia (HP:0000027)2.50857229
54Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.48068319
55Abnormality of potassium homeostasis (HP:0011042)2.44271756
56Generalized aminoaciduria (HP:0002909)2.43968394
57Progressive hearing impairment (HP:0001730)2.43696174
58Hyperuricemia (HP:0002149)2.41239436
59Increased purine levels (HP:0004368)2.41239436
60Chronic bronchitis (HP:0004469)2.38394119
61Intellectual disability, moderate (HP:0002342)2.36458806
62Abnormality of the renal medulla (HP:0100957)2.33001503
63Abnormal drinking behavior (HP:0030082)2.31418402
64Polydipsia (HP:0001959)2.31418402
65Subcapsular cataract (HP:0000523)2.30896970
66Abnormality of the aortic arch (HP:0012303)2.28112395
67Ventricular tachycardia (HP:0004756)2.24790371
68Unilateral renal agenesis (HP:0000122)2.19797666
69Abnormality of renal excretion (HP:0011036)2.17722104
70Hypophosphatemic rickets (HP:0004912)2.17384815
71Osteomalacia (HP:0002749)2.15847494
72Flattened epiphyses (HP:0003071)2.10977471
73Renal dysplasia (HP:0000110)2.08306331
74Congenital malformation of the right heart (HP:0011723)2.05588489
75Double outlet right ventricle (HP:0001719)2.05588489
76Congenital sensorineural hearing impairment (HP:0008527)2.04549335
77Widely patent fontanelles and sutures (HP:0004492)2.02316562
78Polyuria (HP:0000103)2.01669738
79Recurrent pneumonia (HP:0006532)2.00213932
80Glomerulosclerosis (HP:0000096)2.00023622
81Myokymia (HP:0002411)1.99639409
82Bronchiectasis (HP:0002110)1.98305140
83Hypolipoproteinemia (HP:0010981)1.91103833
84Bradycardia (HP:0001662)1.87438907
85Hypoalbuminemia (HP:0003073)1.84592872
86Abnormal albumin level (HP:0012116)1.84592872
87Decreased central vision (HP:0007663)1.84273793
88Hyponatremia (HP:0002902)1.84200492
89Abnormality of the epiphysis of the femoral head (HP:0010574)1.83567693
90Upper limb muscle weakness (HP:0003484)1.82020146
91Sandal gap (HP:0001852)1.79841348
92Optic nerve hypoplasia (HP:0000609)1.79607314
93Epiphyseal dysplasia (HP:0002656)1.79363566
94Insulin resistance (HP:0000855)1.76884423
95Photophobia (HP:0000613)1.73565290
96Renal Fanconi syndrome (HP:0001994)1.72896252
97Abnormality of the parathyroid morphology (HP:0011766)1.71687325
98Abnormality of femoral epiphyses (HP:0006499)1.71449818
99Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.71449818
100Horizontal nystagmus (HP:0000666)1.67557054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK49.60067028
2INSRR4.72728744
3TESK14.72546747
4BRD44.18823662
5DDR23.88095935
6PLK23.67580329
7PNCK3.12411516
8MAP4K22.96602502
9STK382.60453539
10CAMK1G2.46532601
11PIK3CG2.41961194
12PRKD32.13354066
13STK38L2.07771251
14MST1R1.90191736
15MAPK151.80688079
16WNK11.57065272
17TYRO31.55657001
18CDK121.55498174
19PDK11.50179886
20PDPK11.48972079
21NEK61.44409056
22PTK2B1.20485774
23DYRK1B1.16432203
24CDK71.08038463
25CAMK1D0.93428851
26AKT30.87073343
27KSR20.83532409
28MAP3K90.81875177
29PRKG20.77843750
30TIE10.73927285
31MAP3K110.71368121
32SIK20.70870842
33BRAF0.69325233
34WNK40.66254562
35LATS20.62546887
36PRKG10.57302044
37RPS6KA20.56181160
38PRKAA20.55450589
39CAMK10.55106711
40CDK30.54087895
41MAP2K20.53090732
42RPS6KA10.47564312
43PINK10.44758132
44LATS10.43065547
45UHMK10.42593562
46MAP3K20.41292628
47ROCK10.40355969
48MARK10.40186270
49SGK2230.40183416
50SGK4940.40183416
51CDK20.39349849
52MAPK10.38834750
53BMPR1B0.38510137
54GSK3B0.38158461
55CDK10.37802322
56BRSK10.37597611
57STK390.37096405
58MUSK0.36913383
59MAP3K80.36466493
60CAMK40.31630895
61MTOR0.31204877
62NTRK30.30779738
63MAP3K10.30105979
64PRKCG0.30092839
65MET0.28207529
66MAPK80.26547712
67PRKCZ0.25980762
68RPS6KC10.25788797
69RPS6KL10.25788797
70SGK10.25194940
71CHEK10.24306348
72RPS6KA60.22936447
73MARK20.21443345
74ARAF0.20966409
75CDK40.20892867
76BLK0.20754933
77JAK30.19704125
78PRKCB0.19695382
79MAP3K40.19350738
80NEK20.18945718
81MAPK140.18784295
82FRK0.18047521
83MAPK100.17143227
84MAPK110.16545198
85AKT10.14932300
86BRSK20.12965150
87SGK20.12732119
88TESK20.12277633
89NME10.11611166
90TNIK0.11102989
91OXSR10.11019732
92PKN10.10979473
93PRKACB0.09027958
94MAP3K70.06984796
95PRKACA0.06783968
96PRKAA10.04118821
97MAP2K70.03991573
98MAPK90.03655731
99ICK0.03611346
100CAMK2A0.03229493

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.74069787
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.71294232
3Olfactory transduction_Homo sapiens_hsa047404.08142200
4Butanoate metabolism_Homo sapiens_hsa006502.32748917
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.27869707
6Glycerophospholipid metabolism_Homo sapiens_hsa005642.11423653
7RNA transport_Homo sapiens_hsa030131.99689836
8Dorso-ventral axis formation_Homo sapiens_hsa043201.84338299
9Taste transduction_Homo sapiens_hsa047421.81868625
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79376760
11Fatty acid degradation_Homo sapiens_hsa000711.75484615
12Phenylalanine metabolism_Homo sapiens_hsa003601.69395711
13Type II diabetes mellitus_Homo sapiens_hsa049301.59215913
14Fatty acid metabolism_Homo sapiens_hsa012121.56366413
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53895965
16Type I diabetes mellitus_Homo sapiens_hsa049401.41567432
17Antigen processing and presentation_Homo sapiens_hsa046121.35201786
18Allograft rejection_Homo sapiens_hsa053301.30415380
19Autoimmune thyroid disease_Homo sapiens_hsa053201.29511137
20Adipocytokine signaling pathway_Homo sapiens_hsa049201.22700455
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22275361
22Protein digestion and absorption_Homo sapiens_hsa049741.19176040
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17617669
24Graft-versus-host disease_Homo sapiens_hsa053321.16620103
25Arginine biosynthesis_Homo sapiens_hsa002201.15820185
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13423994
27Salivary secretion_Homo sapiens_hsa049701.10881917
28Phototransduction_Homo sapiens_hsa047441.07063507
29Inositol phosphate metabolism_Homo sapiens_hsa005621.06873153
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04242268
31Arginine and proline metabolism_Homo sapiens_hsa003301.02892555
32Viral myocarditis_Homo sapiens_hsa054161.00238989
33ABC transporters_Homo sapiens_hsa020101.00085776
34Endocytosis_Homo sapiens_hsa041440.95755316
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95680571
36PPAR signaling pathway_Homo sapiens_hsa033200.93696625
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93295236
38Primary bile acid biosynthesis_Homo sapiens_hsa001200.92316036
39Calcium signaling pathway_Homo sapiens_hsa040200.92234715
40Oocyte meiosis_Homo sapiens_hsa041140.90499359
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90006283
42Synaptic vesicle cycle_Homo sapiens_hsa047210.89224563
43cAMP signaling pathway_Homo sapiens_hsa040240.87163303
44Influenza A_Homo sapiens_hsa051640.85946348
45Cardiac muscle contraction_Homo sapiens_hsa042600.84938610
46Morphine addiction_Homo sapiens_hsa050320.84890391
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82067532
48Nicotine addiction_Homo sapiens_hsa050330.82009086
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81259429
50Fat digestion and absorption_Homo sapiens_hsa049750.80195564
51Glutamatergic synapse_Homo sapiens_hsa047240.75653533
52Glycerolipid metabolism_Homo sapiens_hsa005610.75515605
53Hedgehog signaling pathway_Homo sapiens_hsa043400.74092377
54Tyrosine metabolism_Homo sapiens_hsa003500.73386431
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72152057
56Circadian entrainment_Homo sapiens_hsa047130.68947860
57VEGF signaling pathway_Homo sapiens_hsa043700.68207341
58Nitrogen metabolism_Homo sapiens_hsa009100.66416362
59Renin secretion_Homo sapiens_hsa049240.62633769
60Estrogen signaling pathway_Homo sapiens_hsa049150.61747674
61Renin-angiotensin system_Homo sapiens_hsa046140.60789987
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57236188
63Retinol metabolism_Homo sapiens_hsa008300.56762086
64Gastric acid secretion_Homo sapiens_hsa049710.56391119
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56039216
66Bile secretion_Homo sapiens_hsa049760.55704063
67Pancreatic secretion_Homo sapiens_hsa049720.54173533
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54042302
69Serotonergic synapse_Homo sapiens_hsa047260.53424576
70Fanconi anemia pathway_Homo sapiens_hsa034600.49511103
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.48828278
72Long-term potentiation_Homo sapiens_hsa047200.47987745
73Insulin secretion_Homo sapiens_hsa049110.47749694
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47688058
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.46257574
76mRNA surveillance pathway_Homo sapiens_hsa030150.45075493
77MAPK signaling pathway_Homo sapiens_hsa040100.41923293
78ECM-receptor interaction_Homo sapiens_hsa045120.41916811
79Purine metabolism_Homo sapiens_hsa002300.39628185
80Biosynthesis of amino acids_Homo sapiens_hsa012300.38953198
81Cholinergic synapse_Homo sapiens_hsa047250.36404809
82Tight junction_Homo sapiens_hsa045300.34617048
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33385465
84Acute myeloid leukemia_Homo sapiens_hsa052210.32036662
85GABAergic synapse_Homo sapiens_hsa047270.29850002
86Oxytocin signaling pathway_Homo sapiens_hsa049210.29424742
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25863769
88Amphetamine addiction_Homo sapiens_hsa050310.25766011
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.25272027
90Selenocompound metabolism_Homo sapiens_hsa004500.21162836
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21063599
92Vitamin B6 metabolism_Homo sapiens_hsa007500.21051965
93Basal transcription factors_Homo sapiens_hsa030220.19554499
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19374702
95Huntingtons disease_Homo sapiens_hsa050160.19325051
96Herpes simplex infection_Homo sapiens_hsa051680.18337093
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.17527177
98Prolactin signaling pathway_Homo sapiens_hsa049170.16695499
99Sulfur relay system_Homo sapiens_hsa041220.15110926
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13666436

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