SPATA31A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.78971367
2DNA packaging (GO:0006323)9.30134630
3sperm capacitation (GO:0048240)8.63385579
4plasma membrane fusion (GO:0045026)8.57440381
5microtubule depolymerization (GO:0007019)8.31239392
6single strand break repair (GO:0000012)8.14807334
7response to pheromone (GO:0019236)8.11340227
8spermatid development (GO:0007286)8.04077931
9protein targeting to Golgi (GO:0000042)7.92323967
10spermatid nucleus differentiation (GO:0007289)7.90764032
11establishment of protein localization to Golgi (GO:0072600)7.60828030
12sperm-egg recognition (GO:0035036)7.51550103
13retrograde transport, vesicle recycling within Golgi (GO:0000301)7.37232797
14protein polyglutamylation (GO:0018095)7.35178412
15rRNA methylation (GO:0031167)7.28822014
16microtubule polymerization or depolymerization (GO:0031109)7.19213160
17binding of sperm to zona pellucida (GO:0007339)7.10340856
18multicellular organism reproduction (GO:0032504)6.98060385
19sexual reproduction (GO:0019953)6.67388927
20reproduction (GO:0000003)6.65509448
21calcium ion-dependent exocytosis (GO:0017156)6.64818449
22axonemal dynein complex assembly (GO:0070286)6.36118138
23* spermatogenesis (GO:0007283)6.28729077
24* male gamete generation (GO:0048232)6.26596104
25negative regulation of inclusion body assembly (GO:0090084)6.22216567
26cell-cell recognition (GO:0009988)6.19413164
27phosphatidylethanolamine biosynthetic process (GO:0006646)6.16700566
28rRNA modification (GO:0000154)6.10136921
29centriole replication (GO:0007099)5.97933725
30* gamete generation (GO:0007276)5.74305896
31protein localization to Golgi apparatus (GO:0034067)5.73372461
32phosphatidylethanolamine metabolic process (GO:0046337)5.69582258
33microtubule severing (GO:0051013)5.68633684
34motile cilium assembly (GO:0044458)5.42679005
35centriole assembly (GO:0098534)5.33158378
36single fertilization (GO:0007338)5.28269361
37seminiferous tubule development (GO:0072520)5.16915632
38cellular ketone body metabolic process (GO:0046950)5.12646764
39regulation of centriole replication (GO:0046599)5.12589754
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.04853860
41regulation of cilium movement (GO:0003352)4.95602099
42glomerular visceral epithelial cell development (GO:0072015)4.93771202
43cilium or flagellum-dependent cell motility (GO:0001539)4.88100417
44positive regulation of Rab GTPase activity (GO:0032851)4.80159080
45regulation of Rab GTPase activity (GO:0032313)4.80159080
46RNA destabilization (GO:0050779)4.77481083
47ketone body metabolic process (GO:1902224)4.72020983
48germ cell development (GO:0007281)4.65196225
49glomerular epithelial cell development (GO:0072310)4.64088535
50chromatin silencing (GO:0006342)4.63852214
51* multicellular organismal reproductive process (GO:0048609)4.58851840
52fertilization (GO:0009566)4.51312401
53cellular process involved in reproduction in multicellular organism (GO:0022412)4.39665527
54regulation of inclusion body assembly (GO:0090083)4.36235807
55cell wall macromolecule catabolic process (GO:0016998)4.29462824
56nucleus organization (GO:0006997)4.29376516
57epithelial cilium movement (GO:0003351)4.28613268
58glycerol ether metabolic process (GO:0006662)4.12198292
59cell wall macromolecule metabolic process (GO:0044036)4.04168242
60microtubule nucleation (GO:0007020)3.82048307
61regulation of transcription involved in cell fate commitment (GO:0060850)3.80166075
62ether metabolic process (GO:0018904)3.80106012
63cilium movement (GO:0003341)3.76095152
64coenzyme catabolic process (GO:0009109)3.76002657
65multicellular organismal movement (GO:0050879)3.72089353
66musculoskeletal movement (GO:0050881)3.72089353
67negative regulation of Rho protein signal transduction (GO:0035024)3.67361908
68protein-DNA complex disassembly (GO:0032986)3.41592069
69nucleosome disassembly (GO:0006337)3.41592069
70organic cation transport (GO:0015695)3.28240055
71nuclear pore complex assembly (GO:0051292)3.26668365
72histone H3-K9 demethylation (GO:0033169)3.24161559
73regulation of interleukin-13 production (GO:0032656)3.23879637
74cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.21981457
75membrane protein intracellular domain proteolysis (GO:0031293)3.18588350
76polyamine biosynthetic process (GO:0006596)3.17920614
77protein depolymerization (GO:0051261)3.16747482
78negative regulation of gene expression, epigenetic (GO:0045814)3.12129098
79regulation of microtubule-based movement (GO:0060632)3.09162767
80cellular response to pH (GO:0071467)3.01518297
81response to acidic pH (GO:0010447)3.00415571
82multicellular organismal development (GO:0007275)3.00320669
83receptor recycling (GO:0001881)2.99934983
84DNA conformation change (GO:0071103)2.99195019
85homeostasis of number of cells within a tissue (GO:0048873)2.99113159
86cell recognition (GO:0008037)2.97524936
87intra-Golgi vesicle-mediated transport (GO:0006891)2.93172923
88mesenchymal cell differentiation involved in renal system development (GO:2001012)2.91393589
89mesenchymal cell differentiation involved in kidney development (GO:0072161)2.91393589
90regulation of phosphoprotein phosphatase activity (GO:0043666)2.90588239
91detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.88379012
92regulation of ARF GTPase activity (GO:0032312)2.87882680
93male meiosis (GO:0007140)2.87867839
94ventricular system development (GO:0021591)2.84154282
95piRNA metabolic process (GO:0034587)2.79285298
96regulation of T-helper 2 cell differentiation (GO:0045628)2.74686932
97cerebral cortex neuron differentiation (GO:0021895)2.68584084
98acrosome reaction (GO:0007340)12.3235857
99sperm motility (GO:0030317)12.1241051
100fusion of sperm to egg plasma membrane (GO:0007342)11.2699786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.12928689
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.82622570
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.59690731
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54468009
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.54468009
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42912047
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.31907475
8CBP_20019798_ChIP-Seq_JUKART_Human2.31907475
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16917182
10FUS_26573619_Chip-Seq_HEK293_Human2.16364469
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10348421
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.06868929
13ERA_21632823_ChIP-Seq_H3396_Human1.94376598
14RAC3_21632823_ChIP-Seq_H3396_Human1.93088059
15DROSHA_22980978_ChIP-Seq_HELA_Human1.87963339
16ELF1_20517297_ChIP-Seq_JURKAT_Human1.85346511
17EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.83261036
18UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77131621
19WDR5_24793694_ChIP-Seq_LNCAP_Human1.75552159
20NANOG_20526341_ChIP-Seq_ESCs_Human1.75325200
21ER_23166858_ChIP-Seq_MCF-7_Human1.70492503
22EZH2_22144423_ChIP-Seq_EOC_Human1.66915356
23CTCF_27219007_Chip-Seq_Bcells_Human1.64251764
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.64094084
25EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.63817701
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63537254
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63385085
28MYC_19829295_ChIP-Seq_ESCs_Human1.63263759
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.63059155
30SMAD4_21741376_ChIP-Seq_EPCs_Human1.55909413
31TAF2_19829295_ChIP-Seq_ESCs_Human1.54485455
32BCL6_27268052_Chip-Seq_Bcells_Human1.51454929
33TDRD3_21172665_ChIP-Seq_MCF-7_Human1.50882710
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50313608
35CBX2_22325352_ChIP-Seq_293T-Rex_Human1.50229591
36SMC4_20622854_ChIP-Seq_HELA_Human1.49799951
37YY1_22570637_ChIP-Seq_MALME-3M_Human1.49424817
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48251882
39HNFA_21074721_ChIP-Seq_CACO-2_Human1.48041908
40RBPJ_21746931_ChIP-Seq_IB4_Human1.46287903
41E2F1_20622854_ChIP-Seq_HELA_Human1.45376371
42CTCF_20526341_ChIP-Seq_ESCs_Human1.44598008
43AUTS2_25519132_ChIP-Seq_293T-REX_Human1.44512081
44CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.43909421
45OCT4_20526341_ChIP-Seq_ESCs_Human1.43189876
46TP53_18474530_ChIP-ChIP_U2OS_Human1.42540826
47BCOR_27268052_Chip-Seq_Bcells_Human1.42061676
48TP63_22573176_ChIP-Seq_HFKS_Human1.40923686
49ETV1_20927104_ChIP-Seq_GIST48_Human1.39152004
50AR_25329375_ChIP-Seq_VCAP_Human1.38588345
51PHF8_20622854_ChIP-Seq_HELA_Human1.37280135
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.36088971
53P68_20966046_ChIP-Seq_HELA_Human1.35777311
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35535299
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34862159
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34638916
57NFYB_21822215_ChIP-Seq_K562_Human1.31780693
58P300_19829295_ChIP-Seq_ESCs_Human1.30750678
59ERG_20517297_ChIP-Seq_VCAP_Human1.29589337
60TBL1_22424771_ChIP-Seq_293T_Human1.29343542
61SMAD3_21741376_ChIP-Seq_ESCs_Human1.27663023
62CEBPB_22108803_ChIP-Seq_LS180_Human1.26931434
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25981161
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25879908
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24400966
66PHF8_20622853_ChIP-Seq_HELA_Human1.24044031
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.23641854
68P300_27268052_Chip-Seq_Bcells_Human1.23575787
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21007014
70GATA6_21074721_ChIP-Seq_CACO-2_Human1.19294583
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18593344
72LXR_22292898_ChIP-Seq_THP-1_Human1.17994829
73SOX2_22085726_ChIP-Seq_NPCs_Mouse1.17114412
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16812296
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16710250
76RUNX_20019798_ChIP-Seq_JUKART_Human1.16497095
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13539237
78SMAD4_21741376_ChIP-Seq_HESCs_Human1.13356255
79PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.13283942
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.12847571
81ZNF274_21170338_ChIP-Seq_K562_Hela1.12146996
82P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11494231
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.11220477
84RUNX2_22187159_ChIP-Seq_PCA_Human1.09339478
85NFYA_21822215_ChIP-Seq_K562_Human1.09168968
86KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.08544370
87SA1_27219007_Chip-Seq_Bcells_Human1.08047929
88P53_21459846_ChIP-Seq_SAOS-2_Human1.06941502
89E2F1_17053090_ChIP-ChIP_MCF-7_Human1.04587227
90SOX2_19829295_ChIP-Seq_ESCs_Human1.04018309
91NANOG_19829295_ChIP-Seq_ESCs_Human1.04018309
92HOXB7_26014856_ChIP-Seq_BT474_Human1.03756282
93STAT3_23295773_ChIP-Seq_U87_Human1.03216078
94VDR_22108803_ChIP-Seq_LS180_Human1.03214638
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02035309
96SMRT_27268052_Chip-Seq_Bcells_Human1.01938486
97TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01458385
98SMAD4_21799915_ChIP-Seq_A2780_Human1.01099289
99OCT1_27270436_Chip-Seq_PROSTATE_Human1.00446443
100TAF15_26573619_Chip-Seq_HEK293_Human0.98086062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot6.12310760
2MP0003878_abnormal_ear_physiology6.12310760
3MP0003698_abnormal_male_reproductive4.32349674
4MP0005670_abnormal_white_adipose4.29716013
5MP0001348_abnormal_lacrimal_gland3.83475436
6MP0001929_abnormal_gametogenesis3.75519433
7MP0003646_muscle_fatigue2.56072898
8MP0002161_abnormal_fertility/fecundity2.36864970
9MP0000678_abnormal_parathyroid_gland2.26476652
10MP0003718_maternal_effect2.14801942
11MP0003011_delayed_dark_adaptation2.12070251
12MP0005410_abnormal_fertilization12.0509808
13MP0001485_abnormal_pinna_reflex1.88804765
14MP0005379_endocrine/exocrine_gland_phen1.84156797
15MP0002132_abnormal_respiratory_system1.80177024
16MP0001486_abnormal_startle_reflex1.65821740
17MP0002210_abnormal_sex_determination1.64525559
18MP0003879_abnormal_hair_cell1.58523740
19MP0004742_abnormal_vestibular_system1.48145386
20MP0005310_abnormal_salivary_gland1.47986717
21MP0005423_abnormal_somatic_nervous1.45835472
22MP0002249_abnormal_larynx_morphology1.44726795
23MP0002282_abnormal_trachea_morphology1.40940955
24MP0005451_abnormal_body_composition1.34856101
25MP0001145_abnormal_male_reproductive1.34546280
26MP0001963_abnormal_hearing_physiology1.28989826
27MP0000653_abnormal_sex_gland1.25730993
28MP0002138_abnormal_hepatobiliary_system1.20855342
29MP0004510_myositis1.19899315
30MP0001765_abnormal_ion_homeostasis1.18978820
31MP0002234_abnormal_pharynx_morphology1.17644588
32MP0009053_abnormal_anal_canal1.12517218
33MP0000026_abnormal_inner_ear1.08752107
34MP0002127_abnormal_cardiovascular_syste1.05524044
35MP0001984_abnormal_olfaction1.05260811
36MP0005248_abnormal_Harderian_gland1.04763693
37MP0004859_abnormal_synaptic_plasticity1.03378104
38MP0005551_abnormal_eye_electrophysiolog0.98234591
39MP0002735_abnormal_chemical_nociception0.97688781
40MP0005395_other_phenotype0.97670342
41MP0000534_abnormal_ureter_morphology0.95617149
42MP0001968_abnormal_touch/_nociception0.91761990
43MP0005408_hypopigmentation0.90003670
44MP0005253_abnormal_eye_physiology0.89434840
45MP0002229_neurodegeneration0.89332093
46MP0009697_abnormal_copulation0.86556672
47MP0009115_abnormal_fat_cell0.79934734
48MP0008877_abnormal_DNA_methylation0.78886552
49MP0005083_abnormal_biliary_tract0.75936122
50MP0000681_abnormal_thyroid_gland0.72515046
51MP0002067_abnormal_sensory_capabilities0.69750466
52MP0000955_abnormal_spinal_cord0.66659316
53MP0005666_abnormal_adipose_tissue0.66326011
54MP0008995_early_reproductive_senescence0.66318291
55MP0004085_abnormal_heartbeat0.65982113
56MP0002733_abnormal_thermal_nociception0.64778650
57MP0005167_abnormal_blood-brain_barrier0.64154079
58MP0000049_abnormal_middle_ear0.62800868
59MP0005636_abnormal_mineral_homeostasis0.62702923
60MP0004036_abnormal_muscle_relaxation0.56904980
61MP0004233_abnormal_muscle_weight0.56612325
62MP0002557_abnormal_social/conspecific_i0.55945446
63MP0001666_abnormal_nutrient_absorption0.54123719
64MP0008569_lethality_at_weaning0.53615924
65MP0001879_abnormal_lymphatic_vessel0.53084749
66MP0002272_abnormal_nervous_system0.50087753
67MP0005367_renal/urinary_system_phenotyp0.49867735
68MP0000516_abnormal_urinary_system0.49867735
69MP0002822_catalepsy0.49806599
70MP0005375_adipose_tissue_phenotype0.49226135
71MP0003172_abnormal_lysosome_physiology0.48507295
72MP0002572_abnormal_emotion/affect_behav0.48064818
73MP0000230_abnormal_systemic_arterial0.47667379
74MP0003137_abnormal_impulse_conducting0.47242291
75MP0005332_abnormal_amino_acid0.46760676
76MP0001501_abnormal_sleep_pattern0.45776526
77MP0000566_synostosis0.45341479
78MP0004084_abnormal_cardiac_muscle0.44779260
79MP0001970_abnormal_pain_threshold0.44061570
80MP0004484_altered_response_of0.43166403
81MP0005535_abnormal_body_temperature0.41061606
82MP0003077_abnormal_cell_cycle0.41029910
83MP0008961_abnormal_basal_metabolism0.39390732
84MP0001905_abnormal_dopamine_level0.39317366
85MP0002928_abnormal_bile_duct0.39044394
86MP0005391_vision/eye_phenotype0.38553853
87MP0005645_abnormal_hypothalamus_physiol0.37463190
88MP0002653_abnormal_ependyma_morphology0.37395822
89MP0002269_muscular_atrophy0.36729967
90MP0000015_abnormal_ear_pigmentation0.35459594
91MP0010329_abnormal_lipoprotein_level0.34873928
92MP0009745_abnormal_behavioral_response0.33982951
93MP0002734_abnormal_mechanical_nocicepti0.33543224
94MP0000003_abnormal_adipose_tissue0.33322866
95MP0000470_abnormal_stomach_morphology0.32117652
96MP0005623_abnormal_meninges_morphology0.32048776
97MP0003936_abnormal_reproductive_system0.29764305
98MP0003631_nervous_system_phenotype0.29697013
99MP0000249_abnormal_blood_vessel0.29292149
100MP0003699_abnormal_female_reproductive0.29064083

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.78465507
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.49594203
3Absent/shortened dynein arms (HP:0200106)6.49594203
4Tubulointerstitial nephritis (HP:0001970)5.95231964
5Asymmetric septal hypertrophy (HP:0001670)5.59936679
6Chronic hepatic failure (HP:0100626)5.52593151
7Abnormal ciliary motility (HP:0012262)4.84092873
8Abnormal respiratory motile cilium physiology (HP:0012261)4.81233121
9Attenuation of retinal blood vessels (HP:0007843)4.80135249
10Bony spicule pigmentary retinopathy (HP:0007737)4.77131746
11Nasal polyposis (HP:0100582)4.65111681
12Resting tremor (HP:0002322)4.59565976
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.48457589
14Male infertility (HP:0003251)4.45039579
15Abnormal respiratory epithelium morphology (HP:0012253)4.40987211
16Abnormal respiratory motile cilium morphology (HP:0005938)4.40987211
17Hyperkalemia (HP:0002153)4.37104908
18Cone-rod dystrophy (HP:0000548)4.34447520
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.27097694
20Abnormality of macular pigmentation (HP:0008002)4.21304099
21Infertility (HP:0000789)4.17671621
22Abnormality of the nasal mucosa (HP:0000433)3.80483806
23Aplasia/Hypoplasia of the earlobes (HP:0009906)3.68494829
24Progressive sensorineural hearing impairment (HP:0000408)3.51290882
25Abnormal rod and cone electroretinograms (HP:0008323)3.48710867
26Facial shape deformation (HP:0011334)3.42623979
27Potter facies (HP:0002009)3.42623979
28Hypoalphalipoproteinemia (HP:0003233)3.41528403
29Amelogenesis imperfecta (HP:0000705)3.39241636
30Bell-shaped thorax (HP:0001591)3.37058621
31Enlarged epiphyses (HP:0010580)3.36694682
32Hypoplasia of the thymus (HP:0000778)3.34077135
33Abnormality of dental color (HP:0011073)3.22723907
34Impulsivity (HP:0100710)3.14154672
35Hypoplastic ischia (HP:0003175)3.07567770
36Menstrual irregularities (HP:0000858)3.06747449
37Abnormal spermatogenesis (HP:0008669)3.06666454
38Stage 5 chronic kidney disease (HP:0003774)3.06466525
39Postural instability (HP:0002172)3.05833572
40Progressive cerebellar ataxia (HP:0002073)2.93819813
41Renovascular hypertension (HP:0100817)2.91402606
42Unilateral renal agenesis (HP:0000122)2.88125153
43Azoospermia (HP:0000027)2.79332073
44Truncal obesity (HP:0001956)2.78424717
45Abnormality of the ischium (HP:0003174)2.73548752
46Insulin-resistant diabetes mellitus (HP:0000831)2.72899482
47Rhinitis (HP:0012384)2.69769331
48Tubulointerstitial abnormality (HP:0001969)2.69069421
49Portal hypertension (HP:0001409)2.65531405
50Focal segmental glomerulosclerosis (HP:0000097)2.61786765
51Abnormal urine output (HP:0012590)2.56366426
52Abnormality of the costochondral junction (HP:0000919)2.54514721
53Nephronophthisis (HP:0000090)2.53249425
54Abnormality of potassium homeostasis (HP:0011042)2.49839285
55Abnormality of the aortic arch (HP:0012303)2.47711202
56Abnormality of the hepatic vasculature (HP:0006707)2.44052799
57Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.42133915
58Generalized aminoaciduria (HP:0002909)2.41402409
59Chronic bronchitis (HP:0004469)2.36843342
60Abnormal drinking behavior (HP:0030082)2.35895404
61Polydipsia (HP:0001959)2.35895404
62Congenital malformation of the right heart (HP:0011723)2.29483580
63Double outlet right ventricle (HP:0001719)2.29483580
64Renal dysplasia (HP:0000110)2.24248983
65Abnormality of renal excretion (HP:0011036)2.22384361
66Progressive hearing impairment (HP:0001730)2.20166997
67Flattened epiphyses (HP:0003071)2.17523390
68Ventricular tachycardia (HP:0004756)2.16341942
69Osteomalacia (HP:0002749)2.16130420
70Abnormality of the renal medulla (HP:0100957)2.16038775
71Hyperuricemia (HP:0002149)2.14865957
72Increased purine levels (HP:0004368)2.14865957
73Intellectual disability, moderate (HP:0002342)2.14466463
74Bronchiectasis (HP:0002110)2.10448540
75Decreased central vision (HP:0007663)2.09461803
76Polyuria (HP:0000103)2.07744184
77Hypophosphatemic rickets (HP:0004912)2.06508408
78Glomerulosclerosis (HP:0000096)2.05917173
79Hypoalbuminemia (HP:0003073)2.03624526
80Abnormal albumin level (HP:0012116)2.03624526
81Congenital sensorineural hearing impairment (HP:0008527)2.02284424
82Abnormality of the parathyroid morphology (HP:0011766)1.98098231
83Subcapsular cataract (HP:0000523)1.95320018
84Myokymia (HP:0002411)1.92626987
85Widely patent fontanelles and sutures (HP:0004492)1.91022388
86Hyponatremia (HP:0002902)1.89877450
87Abnormality of the epiphysis of the femoral head (HP:0010574)1.85298377
88Horizontal nystagmus (HP:0000666)1.82377682
89Optic nerve hypoplasia (HP:0000609)1.81707903
90Recurrent pneumonia (HP:0006532)1.81263821
91Bradycardia (HP:0001662)1.80898833
92Pendular nystagmus (HP:0012043)1.79422224
93Photophobia (HP:0000613)1.79415554
94Renal Fanconi syndrome (HP:0001994)1.75271717
95Flat capital femoral epiphysis (HP:0003370)1.72740344
96Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.72205894
97Abnormality of femoral epiphyses (HP:0006499)1.72205894
98Tetany (HP:0001281)1.71826908
99Tubular atrophy (HP:0000092)1.70191334
100Recurrent corneal erosions (HP:0000495)1.69768559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK49.31215644
2TESK14.96725086
3INSRR4.71782220
4BRD44.13632490
5DDR23.75559140
6PLK23.52386369
7MAP4K23.52367836
8PNCK2.90474466
9STK382.78365425
10PIK3CG2.34886267
11CAMK1G2.24476282
12PRKD31.99819734
13STK38L1.98826731
14MST1R1.97881284
15MAPK151.82160558
16WNK11.80605942
17PDPK11.54782672
18PDK11.53677141
19CDK121.48650448
20NEK61.39123027
21TYRO31.33598787
22PTK2B1.24939137
23DYRK1B1.22905642
24CDK71.07151101
25MAP3K91.01974927
26MAP3K110.86905087
27KSR20.86410002
28PRKG20.85330966
29WNK40.85237395
30LATS20.77066090
31CAMK1D0.76889311
32TIE10.75601058
33AKT30.72048726
34PRKAA20.71302988
35PINK10.65911272
36BRAF0.62772150
37SIK20.62202698
38PRKG10.59106436
39MAP2K20.54019552
40CAMK10.53575378
41CDK30.53045906
42RPS6KA20.52649861
43BMPR1B0.52340091
44STK390.47484622
45RPS6KA10.46548783
46MUSK0.46381832
47UHMK10.45390929
48ROCK10.41560673
49TXK0.39343838
50MAP3K80.38851354
51GSK3B0.38398078
52CDK10.38104012
53MAPK10.38040034
54MARK10.37955636
55LATS10.37546064
56SGK4940.37157092
57SGK2230.37157092
58CDK20.36387863
59MAP3K20.34872643
60MAP3K10.34733049
61BRSK10.34538054
62PRKCG0.31121476
63CAMK40.29826407
64NTRK30.29776908
65MTOR0.29694051
66MET0.28345116
67PRKCZ0.28114319
68SGK10.27985041
69MAPK80.26862339
70NEK20.26020058
71FRK0.25336874
72CDK40.25217613
73BLK0.24610327
74RPS6KC10.24548217
75RPS6KL10.24548217
76NME10.23268862
77CHEK10.22880705
78RPS6KA60.22831967
79OXSR10.21191411
80PRKCB0.20683846
81ARAF0.19536003
82MAPK140.18028535
83MAP3K40.17118273
84AKT10.17094993
85MAPK100.14622633
86MAPK110.12668135
87MAP3K70.12049924
88MARK20.11062860
89DYRK30.10665341
90PKN10.10645897
91PRKACB0.10509602
92PASK0.09829631
93FER0.08482393
94PRKACA0.08364003
95SGK20.07521022
96MARK30.06365756
97BRSK20.05223275
98MAP3K130.05068796
99PRKAA10.04729501
100CAMK2A0.04201235

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.34882810
2Fatty acid biosynthesis_Homo sapiens_hsa000616.25029102
3Olfactory transduction_Homo sapiens_hsa047404.21418626
4Butanoate metabolism_Homo sapiens_hsa006502.57286082
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.13976008
6Glycerophospholipid metabolism_Homo sapiens_hsa005641.98328033
7Taste transduction_Homo sapiens_hsa047421.83912683
8RNA transport_Homo sapiens_hsa030131.83863152
9Type I diabetes mellitus_Homo sapiens_hsa049401.79027487
10Allograft rejection_Homo sapiens_hsa053301.76881707
11Antigen processing and presentation_Homo sapiens_hsa046121.76783429
12Dorso-ventral axis formation_Homo sapiens_hsa043201.75558993
13Autoimmune thyroid disease_Homo sapiens_hsa053201.73662738
14Phenylalanine metabolism_Homo sapiens_hsa003601.65041343
15Graft-versus-host disease_Homo sapiens_hsa053321.62975037
16Type II diabetes mellitus_Homo sapiens_hsa049301.54389183
17Fatty acid degradation_Homo sapiens_hsa000711.51537927
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37894736
19Fatty acid metabolism_Homo sapiens_hsa012121.36722852
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33224039
21Arginine and proline metabolism_Homo sapiens_hsa003301.27357293
22Viral myocarditis_Homo sapiens_hsa054161.23388682
23Arginine biosynthesis_Homo sapiens_hsa002201.22849539
24Salivary secretion_Homo sapiens_hsa049701.21631451
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21423859
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13280171
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12588106
28Phototransduction_Homo sapiens_hsa047441.07870409
29Protein digestion and absorption_Homo sapiens_hsa049741.04403645
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03484188
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03079031
32Inositol phosphate metabolism_Homo sapiens_hsa005621.00552834
33Endocytosis_Homo sapiens_hsa041440.99868164
34Cardiac muscle contraction_Homo sapiens_hsa042600.99561358
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99504335
36Adipocytokine signaling pathway_Homo sapiens_hsa049200.98223234
37Primary bile acid biosynthesis_Homo sapiens_hsa001200.94672442
38Tyrosine metabolism_Homo sapiens_hsa003500.92907903
39Oocyte meiosis_Homo sapiens_hsa041140.90937723
40Influenza A_Homo sapiens_hsa051640.90905930
41Calcium signaling pathway_Homo sapiens_hsa040200.90876946
42ABC transporters_Homo sapiens_hsa020100.84838392
43Nicotine addiction_Homo sapiens_hsa050330.84789106
44cAMP signaling pathway_Homo sapiens_hsa040240.83894038
45Morphine addiction_Homo sapiens_hsa050320.82854631
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82054483
47PPAR signaling pathway_Homo sapiens_hsa033200.80085075
48Fat digestion and absorption_Homo sapiens_hsa049750.79780212
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77367367
50Nitrogen metabolism_Homo sapiens_hsa009100.74707281
51Hedgehog signaling pathway_Homo sapiens_hsa043400.73114229
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72353706
53Glycerolipid metabolism_Homo sapiens_hsa005610.70185020
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68376746
55Circadian entrainment_Homo sapiens_hsa047130.64678170
56Retinol metabolism_Homo sapiens_hsa008300.63868065
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63556297
58Glutamatergic synapse_Homo sapiens_hsa047240.61220477
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59765092
60Synaptic vesicle cycle_Homo sapiens_hsa047210.59634304
61Estrogen signaling pathway_Homo sapiens_hsa049150.58704682
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55752875
63Renin secretion_Homo sapiens_hsa049240.55174950
64VEGF signaling pathway_Homo sapiens_hsa043700.54826792
65Renin-angiotensin system_Homo sapiens_hsa046140.50965020
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49160081
67Insulin secretion_Homo sapiens_hsa049110.48344272
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.47958402
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.47452654
70Bile secretion_Homo sapiens_hsa049760.46921908
71Pancreatic secretion_Homo sapiens_hsa049720.46415153
72Purine metabolism_Homo sapiens_hsa002300.46336006
73mRNA surveillance pathway_Homo sapiens_hsa030150.44510860
74Gastric acid secretion_Homo sapiens_hsa049710.44446536
75Vitamin B6 metabolism_Homo sapiens_hsa007500.43070129
76MAPK signaling pathway_Homo sapiens_hsa040100.41698684
77Serotonergic synapse_Homo sapiens_hsa047260.41631686
78Fanconi anemia pathway_Homo sapiens_hsa034600.40502307
79Basal transcription factors_Homo sapiens_hsa030220.40171803
80Biosynthesis of amino acids_Homo sapiens_hsa012300.36848687
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32513906
82ECM-receptor interaction_Homo sapiens_hsa045120.32110395
83Long-term potentiation_Homo sapiens_hsa047200.32038567
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.29648215
85Acute myeloid leukemia_Homo sapiens_hsa052210.28463448
86Cholinergic synapse_Homo sapiens_hsa047250.27960537
87GABAergic synapse_Homo sapiens_hsa047270.27073408
88Herpes simplex infection_Homo sapiens_hsa051680.25256955
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23941629
90Tight junction_Homo sapiens_hsa045300.23460016
91Sulfur relay system_Homo sapiens_hsa041220.23314314
92Huntingtons disease_Homo sapiens_hsa050160.22406753
93Oxytocin signaling pathway_Homo sapiens_hsa049210.22347097
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.20034159
95Amphetamine addiction_Homo sapiens_hsa050310.18639779
96Legionellosis_Homo sapiens_hsa051340.17984512
97Chemical carcinogenesis_Homo sapiens_hsa052040.17277491
98Metabolic pathways_Homo sapiens_hsa011000.15713495
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13352076
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.12959091

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