SPATA31A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)8.78152342
2spermatid development (GO:0007286)8.56061194
3chromosome condensation (GO:0030261)8.44336709
4protein targeting to Golgi (GO:0000042)8.38226842
5DNA packaging (GO:0006323)8.24855700
6microtubule depolymerization (GO:0007019)8.17147444
7plasma membrane fusion (GO:0045026)8.08886997
8establishment of protein localization to Golgi (GO:0072600)8.04937574
9protein polyglutamylation (GO:0018095)7.84668239
10retrograde transport, vesicle recycling within Golgi (GO:0000301)7.82562252
11microtubule polymerization or depolymerization (GO:0031109)7.21473449
12sperm-egg recognition (GO:0035036)7.20810356
13multicellular organism reproduction (GO:0032504)7.17586161
14single strand break repair (GO:0000012)7.17295385
15rRNA methylation (GO:0031167)6.97380279
16spermatid nucleus differentiation (GO:0007289)6.87886885
17phosphatidylethanolamine biosynthetic process (GO:0006646)6.75070208
18centriole replication (GO:0007099)6.70375425
19binding of sperm to zona pellucida (GO:0007339)6.49461541
20reproduction (GO:0000003)6.47335319
21calcium ion-dependent exocytosis (GO:0017156)6.35601439
22* spermatogenesis (GO:0007283)6.33466444
23* male gamete generation (GO:0048232)6.31376235
24negative regulation of inclusion body assembly (GO:0090084)6.24845572
25axonemal dynein complex assembly (GO:0070286)6.23494679
26phosphatidylethanolamine metabolic process (GO:0046337)6.22485297
27protein localization to Golgi apparatus (GO:0034067)6.02989911
28centriole assembly (GO:0098534)5.99732267
29microtubule severing (GO:0051013)5.96499458
30cell-cell recognition (GO:0009988)5.93267979
31rRNA modification (GO:0000154)5.84910343
32* gamete generation (GO:0007276)5.82374458
33regulation of cilium movement (GO:0003352)5.68482650
34regulation of centriole replication (GO:0046599)5.65014864
35cilium or flagellum-dependent cell motility (GO:0001539)5.64945228
36sexual reproduction (GO:0019953)5.48135640
37seminiferous tubule development (GO:0072520)5.47293807
38single fertilization (GO:0007338)5.42318101
39response to pheromone (GO:0019236)5.35632181
40RNA destabilization (GO:0050779)5.11287985
41motile cilium assembly (GO:0044458)4.97608902
42germ cell development (GO:0007281)4.94958456
43fertilization (GO:0009566)4.88446269
44positive regulation of Rab GTPase activity (GO:0032851)4.83638362
45regulation of Rab GTPase activity (GO:0032313)4.83638362
46epithelial cilium movement (GO:0003351)4.80772013
47* multicellular organismal reproductive process (GO:0048609)4.66621756
48cellular process involved in reproduction in multicellular organism (GO:0022412)4.64718676
49regulation of inclusion body assembly (GO:0090083)4.39071757
50nucleus organization (GO:0006997)4.38894870
51regulation of transcription involved in cell fate commitment (GO:0060850)4.37240644
52microtubule nucleation (GO:0007020)4.36433257
53multicellular organismal movement (GO:0050879)4.24625140
54musculoskeletal movement (GO:0050881)4.24625140
55glomerular visceral epithelial cell development (GO:0072015)4.23125163
56cilium movement (GO:0003341)4.17297600
57cell wall macromolecule catabolic process (GO:0016998)4.16528628
58cell wall macromolecule metabolic process (GO:0044036)4.15397004
59cellular ketone body metabolic process (GO:0046950)4.12462178
60nuclear pore complex assembly (GO:0051292)4.01622764
61glomerular epithelial cell development (GO:0072310)3.96538925
62male meiosis (GO:0007140)3.93536203
63organic cation transport (GO:0015695)3.89942696
64male meiosis I (GO:0007141)3.89158842
65piRNA metabolic process (GO:0034587)3.86618114
66regulation of microtubule-based movement (GO:0060632)3.73633347
67histone H3-K9 demethylation (GO:0033169)3.69798855
68DNA methylation involved in gamete generation (GO:0043046)3.67928342
69ketone body metabolic process (GO:1902224)3.63393666
70membrane protein intracellular domain proteolysis (GO:0031293)3.57149673
71response to acidic pH (GO:0010447)3.56269092
72chromatin silencing (GO:0006342)3.54810122
73cellular response to pH (GO:0071467)3.49276725
74Golgi to endosome transport (GO:0006895)3.44586801
75polyamine biosynthetic process (GO:0006596)3.38326829
76nucleosome disassembly (GO:0006337)3.34613202
77protein-DNA complex disassembly (GO:0032986)3.34613202
78intra-Golgi vesicle-mediated transport (GO:0006891)3.31379423
79regulation of meiosis I (GO:0060631)3.22978918
80ventricular system development (GO:0021591)3.20957669
81glycerol ether metabolic process (GO:0006662)3.16440925
82multicellular organismal development (GO:0007275)3.15861412
83regulation of phosphoprotein phosphatase activity (GO:0043666)3.11804206
84protein depolymerization (GO:0051261)3.10955773
85homeostasis of number of cells within a tissue (GO:0048873)3.08895584
86pore complex assembly (GO:0046931)3.07569453
87cerebral cortex neuron differentiation (GO:0021895)3.04369869
88peptidyl-threonine dephosphorylation (GO:0035970)2.99627641
89positive regulation of guanylate cyclase activity (GO:0031284)2.98942037
90axoneme assembly (GO:0035082)2.98544479
91nuclear pore organization (GO:0006999)2.97183934
92meiosis I (GO:0007127)2.93526776
93RNA localization (GO:0006403)2.92274822
94ether metabolic process (GO:0018904)2.91161381
95meiotic nuclear division (GO:0007126)2.87491677
96regulation of guanylate cyclase activity (GO:0031282)2.85765200
97cell recognition (GO:0008037)2.85196286
98sperm motility (GO:0030317)12.3246276
99acrosome reaction (GO:0007340)11.3098187
100fusion of sperm to egg plasma membrane (GO:0007342)10.6646690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.40632987
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.98671622
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.46034839
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.23265458
5EZH2_22144423_ChIP-Seq_EOC_Human2.68567878
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.60983241
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.52137027
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52137027
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.32844369
10CBP_20019798_ChIP-Seq_JUKART_Human2.32844369
11FUS_26573619_Chip-Seq_HEK293_Human2.31161343
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.23847234
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.23061310
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19228640
15RAC3_21632823_ChIP-Seq_H3396_Human1.84783503
16DROSHA_22980978_ChIP-Seq_HELA_Human1.82125535
17ERA_21632823_ChIP-Seq_H3396_Human1.75603640
18ELF1_20517297_ChIP-Seq_JURKAT_Human1.73718872
19NANOG_20526341_ChIP-Seq_ESCs_Human1.66628383
20UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66285291
21ER_23166858_ChIP-Seq_MCF-7_Human1.65975061
22CTCF_27219007_Chip-Seq_Bcells_Human1.64462708
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.64080474
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63698594
25SMAD4_21741376_ChIP-Seq_EPCs_Human1.61198262
26MYC_19829295_ChIP-Seq_ESCs_Human1.61140636
27EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.59918865
28EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.59702731
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.59375368
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.56670760
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54126555
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53691048
33SMC4_20622854_ChIP-Seq_HELA_Human1.53290502
34YY1_22570637_ChIP-Seq_MALME-3M_Human1.51398770
35CBX2_22325352_ChIP-Seq_293T-Rex_Human1.50797902
36TAF2_19829295_ChIP-Seq_ESCs_Human1.50120287
37AR_25329375_ChIP-Seq_VCAP_Human1.48168268
38BCL6_27268052_Chip-Seq_Bcells_Human1.47320682
39ERG_20517297_ChIP-Seq_VCAP_Human1.46789259
40RBPJ_21746931_ChIP-Seq_IB4_Human1.46608988
41OCT4_20526341_ChIP-Seq_ESCs_Human1.46493109
42HNFA_21074721_ChIP-Seq_CACO-2_Human1.45432719
43CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.43966988
44ETV1_20927104_ChIP-Seq_GIST48_Human1.43882655
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43181438
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.41359642
47TDRD3_21172665_ChIP-Seq_MCF-7_Human1.41225073
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.39868961
49BCOR_27268052_Chip-Seq_Bcells_Human1.37027429
50P68_20966046_ChIP-Seq_HELA_Human1.36610934
51NFYB_21822215_ChIP-Seq_K562_Human1.35080349
52TBL1_22424771_ChIP-Seq_293T_Human1.34544208
53P300_19829295_ChIP-Seq_ESCs_Human1.33751232
54CTCF_20526341_ChIP-Seq_ESCs_Human1.32857995
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32245999
56PHF8_20622854_ChIP-Seq_HELA_Human1.31660189
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31229132
58TP63_22573176_ChIP-Seq_HFKS_Human1.30641666
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30390417
60SMAD3_21741376_ChIP-Seq_ESCs_Human1.29505659
61E2F1_20622854_ChIP-Seq_HELA_Human1.29451316
62AR_21572438_ChIP-Seq_LNCaP_Human1.29048977
63PHF8_20622853_ChIP-Seq_HELA_Human1.28841151
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24842674
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23810729
66P300_27268052_Chip-Seq_Bcells_Human1.22940939
67TP53_18474530_ChIP-ChIP_U2OS_Human1.22686198
68STAT3_23295773_ChIP-Seq_U87_Human1.20209005
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19038864
70SMAD4_21799915_ChIP-Seq_A2780_Human1.19025494
71CEBPB_22108803_ChIP-Seq_LS180_Human1.18884429
72GATA6_21074721_ChIP-Seq_CACO-2_Human1.18716537
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18631868
74P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.17526704
75PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15944852
76RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15018366
77SOX2_22085726_ChIP-Seq_NPCs_Mouse1.14669046
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14375497
79NFYA_21822215_ChIP-Seq_K562_Human1.13437832
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12785512
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.12565414
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12389092
83RUNX2_22187159_ChIP-Seq_PCA_Human1.11544033
84ZNF274_21170338_ChIP-Seq_K562_Hela1.11000054
85KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10783592
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09929904
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07536813
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.06883695
89TAF15_26573619_Chip-Seq_HEK293_Human1.06533513
90LXR_22292898_ChIP-Seq_THP-1_Human1.04968646
91OCT1_27270436_Chip-Seq_PROSTATE_Human1.04168960
92SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03674659
93SOX2_19829295_ChIP-Seq_ESCs_Human1.02565845
94NANOG_19829295_ChIP-Seq_ESCs_Human1.02565845
95BP1_19119308_ChIP-ChIP_Hs578T_Human1.01771733
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01252800
97SMRT_27268052_Chip-Seq_Bcells_Human1.01166335
98SMAD4_21741376_ChIP-Seq_HESCs_Human1.00749539
99P53_21459846_ChIP-Seq_SAOS-2_Human0.99983993
100GBX2_23144817_ChIP-Seq_PC3_Human0.99103008

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology5.69081595
2MP0005377_hearing/vestibular/ear_phenot5.69081595
3MP0005670_abnormal_white_adipose4.79159852
4MP0003698_abnormal_male_reproductive4.71979732
5MP0001929_abnormal_gametogenesis4.28472252
6MP0001348_abnormal_lacrimal_gland3.07705133
7MP0002161_abnormal_fertility/fecundity2.60745069
8MP0003646_muscle_fatigue2.49230333
9MP0002210_abnormal_sex_determination2.34041991
10MP0005451_abnormal_body_composition2.32912746
11MP0003718_maternal_effect2.09324709
12MP0005410_abnormal_fertilization12.0072616
13MP0001485_abnormal_pinna_reflex1.90309492
14MP0000678_abnormal_parathyroid_gland1.87412722
15MP0001145_abnormal_male_reproductive1.82392977
16MP0008877_abnormal_DNA_methylation1.78421610
17MP0000653_abnormal_sex_gland1.70854959
18MP0003879_abnormal_hair_cell1.61573206
19MP0005379_endocrine/exocrine_gland_phen1.59825989
20MP0001486_abnormal_startle_reflex1.59643458
21MP0005310_abnormal_salivary_gland1.56609090
22MP0002132_abnormal_respiratory_system1.51547271
23MP0004742_abnormal_vestibular_system1.32609434
24MP0002822_catalepsy1.27192889
25MP0005423_abnormal_somatic_nervous1.24780583
26MP0002282_abnormal_trachea_morphology1.24479948
27MP0003011_delayed_dark_adaptation1.22865676
28MP0004859_abnormal_synaptic_plasticity1.22626387
29MP0001963_abnormal_hearing_physiology1.14184024
30MP0002138_abnormal_hepatobiliary_system1.12655812
31MP0009115_abnormal_fat_cell1.11255862
32MP0001765_abnormal_ion_homeostasis1.04543349
33MP0002249_abnormal_larynx_morphology1.02802344
34MP0001984_abnormal_olfaction0.98228929
35MP0005666_abnormal_adipose_tissue0.97185400
36MP0005551_abnormal_eye_electrophysiolog0.96350665
37MP0008995_early_reproductive_senescence0.95860076
38MP0009053_abnormal_anal_canal0.93598956
39MP0000534_abnormal_ureter_morphology0.91759380
40MP0009697_abnormal_copulation0.91453703
41MP0005395_other_phenotype0.90653681
42MP0000026_abnormal_inner_ear0.89418694
43MP0005253_abnormal_eye_physiology0.89254366
44MP0002735_abnormal_chemical_nociception0.84579240
45MP0001968_abnormal_touch/_nociception0.81130669
46MP0002127_abnormal_cardiovascular_syste0.80724582
47MP0001905_abnormal_dopamine_level0.80314466
48MP0002229_neurodegeneration0.78154920
49MP0000955_abnormal_spinal_cord0.77985889
50MP0002234_abnormal_pharynx_morphology0.76678421
51MP0002067_abnormal_sensory_capabilities0.76612922
52MP0005083_abnormal_biliary_tract0.75678933
53MP0005167_abnormal_blood-brain_barrier0.74586002
54MP0004233_abnormal_muscle_weight0.74299189
55MP0008569_lethality_at_weaning0.70687964
56MP0005248_abnormal_Harderian_gland0.65612576
57MP0002557_abnormal_social/conspecific_i0.64313988
58MP0004085_abnormal_heartbeat0.64189780
59MP0004510_myositis0.63691266
60MP0003077_abnormal_cell_cycle0.63442700
61MP0005375_adipose_tissue_phenotype0.61950534
62MP0002572_abnormal_emotion/affect_behav0.61262241
63MP0004036_abnormal_muscle_relaxation0.59360199
64MP0000230_abnormal_systemic_arterial0.49810774
65MP0001440_abnormal_grooming_behavior0.48847681
66MP0005636_abnormal_mineral_homeostasis0.48804748
67MP0002928_abnormal_bile_duct0.48737385
68MP0001666_abnormal_nutrient_absorption0.47982967
69MP0009745_abnormal_behavioral_response0.47516240
70MP0008004_abnormal_stomach_pH0.47038621
71MP0002272_abnormal_nervous_system0.46201276
72MP0005397_hematopoietic_system_phenotyp0.45408392
73MP0001545_abnormal_hematopoietic_system0.45408392
74MP0002733_abnormal_thermal_nociception0.45053839
75MP0003699_abnormal_female_reproductive0.43357671
76MP0003631_nervous_system_phenotype0.42384129
77MP0005535_abnormal_body_temperature0.42191828
78MP0001270_distended_abdomen0.40243133
79MP0005647_abnormal_sex_gland0.39695470
80MP0003936_abnormal_reproductive_system0.39691278
81MP0005391_vision/eye_phenotype0.39587591
82MP0002160_abnormal_reproductive_system0.39262051
83MP0004084_abnormal_cardiac_muscle0.39211999
84MP0010329_abnormal_lipoprotein_level0.38886156
85MP0001501_abnormal_sleep_pattern0.38063439
86MP0003119_abnormal_digestive_system0.37341255
87MP0000681_abnormal_thyroid_gland0.37196162
88MP0000049_abnormal_middle_ear0.36013566
89MP0000003_abnormal_adipose_tissue0.35829566
90MP0002734_abnormal_mechanical_nocicepti0.34711468
91MP0003137_abnormal_impulse_conducting0.34123346
92MP0005645_abnormal_hypothalamus_physiol0.32976050
93MP0005408_hypopigmentation0.32548103
94MP0003633_abnormal_nervous_system0.32423695
95MP0002269_muscular_atrophy0.32317826
96MP0003632_abnormal_nervous_system0.32262453
97MP0000470_abnormal_stomach_morphology0.32113440
98MP0003635_abnormal_synaptic_transmissio0.32069526
99MP0005595_abnormal_vascular_smooth0.31940275
100MP0001970_abnormal_pain_threshold0.31241714

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.13880009
2Tubulointerstitial nephritis (HP:0001970)7.07833990
3Chronic hepatic failure (HP:0100626)6.41500693
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.16818952
5Absent/shortened dynein arms (HP:0200106)6.16818952
6Asymmetric septal hypertrophy (HP:0001670)5.65256658
7Resting tremor (HP:0002322)4.97999344
8Hyperkalemia (HP:0002153)4.86058321
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.77621491
10Abnormal respiratory motile cilium physiology (HP:0012261)4.72284643
11Abnormal ciliary motility (HP:0012262)4.68932291
12Male infertility (HP:0003251)4.61371996
13Cone-rod dystrophy (HP:0000548)4.55018344
14Bony spicule pigmentary retinopathy (HP:0007737)4.44428583
15Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.43005923
16Attenuation of retinal blood vessels (HP:0007843)4.37221861
17Abnormal respiratory motile cilium morphology (HP:0005938)4.29209487
18Abnormal respiratory epithelium morphology (HP:0012253)4.29209487
19Infertility (HP:0000789)4.26384026
20Nasal polyposis (HP:0100582)4.24866434
21Abnormality of macular pigmentation (HP:0008002)4.23272108
22Hypoalphalipoproteinemia (HP:0003233)4.10933131
23Menstrual irregularities (HP:0000858)4.04391992
24Progressive sensorineural hearing impairment (HP:0000408)3.70186302
25Bell-shaped thorax (HP:0001591)3.67068662
26Aplasia/Hypoplasia of the earlobes (HP:0009906)3.63457351
27Hypoplasia of the thymus (HP:0000778)3.61591206
28Impulsivity (HP:0100710)3.50257000
29Abnormality of the nasal mucosa (HP:0000433)3.45740050
30Renovascular hypertension (HP:0100817)3.42503111
31Postural instability (HP:0002172)3.40769122
32Truncal obesity (HP:0001956)3.33219713
33Potter facies (HP:0002009)3.29384236
34Facial shape deformation (HP:0011334)3.29384236
35Tubulointerstitial abnormality (HP:0001969)3.26229361
36Abnormality of dental color (HP:0011073)3.24617893
37Amelogenesis imperfecta (HP:0000705)3.20778343
38Insulin-resistant diabetes mellitus (HP:0000831)3.14533659
39Portal hypertension (HP:0001409)3.11768196
40Progressive cerebellar ataxia (HP:0002073)3.02146963
41Nephronophthisis (HP:0000090)3.01993800
42Abnormal rod and cone electroretinograms (HP:0008323)3.00796489
43Enlarged epiphyses (HP:0010580)2.97935705
44Stage 5 chronic kidney disease (HP:0003774)2.92373328
45Abnormality of the hepatic vasculature (HP:0006707)2.87916882
46Rhinitis (HP:0012384)2.85654290
47Abnormal spermatogenesis (HP:0008669)2.84636365
48Hypoplastic ischia (HP:0003175)2.77915406
49Hyperuricemia (HP:0002149)2.65537880
50Increased purine levels (HP:0004368)2.65537880
51Abnormality of the renal medulla (HP:0100957)2.63325190
52Abnormality of the ischium (HP:0003174)2.52767279
53Abnormality of potassium homeostasis (HP:0011042)2.52278864
54Abnormal urine output (HP:0012590)2.51949061
55Abnormality of the costochondral junction (HP:0000919)2.50518984
56Intellectual disability, moderate (HP:0002342)2.48549441
57Chronic bronchitis (HP:0004469)2.47275228
58Subcapsular cataract (HP:0000523)2.46131765
59Osteomalacia (HP:0002749)2.45077509
60Progressive hearing impairment (HP:0001730)2.39674393
61Abnormal drinking behavior (HP:0030082)2.38393222
62Polydipsia (HP:0001959)2.38393222
63Generalized aminoaciduria (HP:0002909)2.35935880
64Azoospermia (HP:0000027)2.33183314
65Abnormality of renal excretion (HP:0011036)2.27158945
66Horizontal nystagmus (HP:0000666)2.26730386
67Flattened epiphyses (HP:0003071)2.10450822
68Recurrent pneumonia (HP:0006532)2.09968369
69Hypolipoproteinemia (HP:0010981)2.08205518
70Focal segmental glomerulosclerosis (HP:0000097)2.06697143
71Bronchiectasis (HP:0002110)2.06157956
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.04415111
73Polyuria (HP:0000103)2.02143292
74Myokymia (HP:0002411)1.99517786
75Optic nerve hypoplasia (HP:0000609)1.94487557
76Widely patent fontanelles and sutures (HP:0004492)1.91555550
77Hypophosphatemic rickets (HP:0004912)1.90489625
78Congenital sensorineural hearing impairment (HP:0008527)1.87353483
79Occipital encephalocele (HP:0002085)1.86668185
80Insulin resistance (HP:0000855)1.80844028
81Ventricular tachycardia (HP:0004756)1.80394158
82Renal dysplasia (HP:0000110)1.79480199
83Abnormality of the aortic arch (HP:0012303)1.77437827
84Abnormality of purine metabolism (HP:0004352)1.77349794
85Sandal gap (HP:0001852)1.77129370
86Abnormality of chloride homeostasis (HP:0011422)1.75878999
87Tubular atrophy (HP:0000092)1.75741930
88Photophobia (HP:0000613)1.73553787
89Upper limb muscle weakness (HP:0003484)1.70290225
90Epiphyseal dysplasia (HP:0002656)1.65940680
91Gingivitis (HP:0000230)1.65815085
92Obsessive-compulsive behavior (HP:0000722)1.65783280
93Abnormality of the epiphysis of the femoral head (HP:0010574)1.65618040
94Hyponatremia (HP:0002902)1.65386040
95Glomerulosclerosis (HP:0000096)1.63875284
96Renal Fanconi syndrome (HP:0001994)1.62179777
97Hypoalbuminemia (HP:0003073)1.61331021
98Abnormal albumin level (HP:0012116)1.61331021
99Hypergonadotropic hypogonadism (HP:0000815)1.58307420
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.58033799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK49.14066157
2PNCK5.17736404
3INSRR4.13494504
4TESK14.11258338
5BRD43.76405945
6PLK23.69577570
7DDR23.37519175
8CAMK1G3.21358241
9STK383.05258770
10STK38L2.39354131
11PRKD32.22407601
12MAP4K22.18690791
13PIK3CG2.08990803
14MST1R1.96482958
15PTK2B1.80942762
16MAPK151.65047862
17TYRO31.62258389
18NEK61.55640574
19PDPK11.44883327
20PDK11.43007390
21CDK121.37649274
22MET1.37416990
23DYRK1B1.15777246
24WNK11.10872418
25PINK11.04642458
26CDK70.95746950
27SIK20.87666032
28MAP3K90.87442585
29AKT30.86484549
30CAMK1D0.78939110
31LATS10.73235993
32BRAF0.72749297
33KSR20.72679534
34PRKG20.70812353
35CAMK10.64361649
36PRKG10.60393435
37TIE10.60353905
38CDK30.59250134
39MAP3K110.57617410
40ROCK10.55387331
41MAP2K20.54472139
42MAP3K20.49237869
43RPS6KA20.47395992
44RPS6KA10.47207471
45SGK4940.45687150
46SGK2230.45687150
47CDK190.44298813
48OXSR10.43823766
49NEK20.43663000
50LATS20.40160209
51CDK20.39933400
52MAPK10.37787049
53GSK3B0.36539124
54CDK10.36395186
55MARK30.34386168
56CSF1R0.33814484
57UHMK10.32962565
58ARAF0.32663168
59BRSK10.32303051
60SGK10.32139069
61PRKAA20.31817921
62JAK30.31377627
63MTOR0.31151198
64CHEK10.29973724
65MAP3K40.28851177
66MAP3K10.28624313
67MARK10.28613717
68STK390.28579513
69NTRK30.27670437
70PRKCZ0.24603632
71MAPK80.24577645
72BMX0.24122394
73MAP3K80.24086608
74BMPR1B0.22764525
75PRKCG0.22647596
76RPS6KC10.20682634
77RPS6KL10.20682634
78MAPK110.20323863
79WNK40.19564859
80PRKCB0.18888648
81MAPK100.18297860
82SGK20.17822319
83MAPK140.17543117
84RPS6KA60.17532017
85CAMK40.17422026
86RIPK40.15559916
87CDK40.15198767
88MAP2K70.13511595
89FGR0.13076665
90RET0.12748431
91MARK20.12264926
92MAP3K100.12088557
93MUSK0.11356241
94AKT10.10238586
95TNIK0.09454880
96PKN10.09162052
97DYRK30.08785903
98TESK20.08019095
99PRKACB0.07993202
100BRSK20.07786978

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.52749047
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.89217146
3Olfactory transduction_Homo sapiens_hsa047403.81923507
4Glycerophospholipid metabolism_Homo sapiens_hsa005642.24366275
5RNA transport_Homo sapiens_hsa030132.21956502
6Dorso-ventral axis formation_Homo sapiens_hsa043202.04855577
7Butanoate metabolism_Homo sapiens_hsa006502.02483219
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92434945
9Fatty acid degradation_Homo sapiens_hsa000711.90340777
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90081944
11Fatty acid metabolism_Homo sapiens_hsa012121.79174009
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.67618849
13Taste transduction_Homo sapiens_hsa047421.66751096
14Phenylalanine metabolism_Homo sapiens_hsa003601.57721926
15Adipocytokine signaling pathway_Homo sapiens_hsa049201.52967658
16Type II diabetes mellitus_Homo sapiens_hsa049301.52018865
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45837236
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.33547117
19Phototransduction_Homo sapiens_hsa047441.17878071
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12551449
21Protein digestion and absorption_Homo sapiens_hsa049741.12403368
22PPAR signaling pathway_Homo sapiens_hsa033201.11272920
23Synaptic vesicle cycle_Homo sapiens_hsa047211.11091306
24ABC transporters_Homo sapiens_hsa020101.06179108
25Inositol phosphate metabolism_Homo sapiens_hsa005621.05878001
26Arginine biosynthesis_Homo sapiens_hsa002201.05379747
27Hedgehog signaling pathway_Homo sapiens_hsa043401.01514302
28Calcium signaling pathway_Homo sapiens_hsa040201.01137212
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99600632
30Oocyte meiosis_Homo sapiens_hsa041140.99113521
31Antigen processing and presentation_Homo sapiens_hsa046120.94557878
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93843739
33Morphine addiction_Homo sapiens_hsa050320.92596779
34Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89202863
35Salivary secretion_Homo sapiens_hsa049700.89125583
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88614786
37Nicotine addiction_Homo sapiens_hsa050330.86753053
38Endocytosis_Homo sapiens_hsa041440.86669970
39Primary bile acid biosynthesis_Homo sapiens_hsa001200.85754047
40VEGF signaling pathway_Homo sapiens_hsa043700.85012851
41Selenocompound metabolism_Homo sapiens_hsa004500.83441169
42Type I diabetes mellitus_Homo sapiens_hsa049400.79461267
43cAMP signaling pathway_Homo sapiens_hsa040240.79411739
44Fat digestion and absorption_Homo sapiens_hsa049750.78416631
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77673997
46Glutamatergic synapse_Homo sapiens_hsa047240.77461898
47Glycerolipid metabolism_Homo sapiens_hsa005610.77240484
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77005811
49Circadian entrainment_Homo sapiens_hsa047130.76144643
50Nitrogen metabolism_Homo sapiens_hsa009100.73876191
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73493602
52Influenza A_Homo sapiens_hsa051640.72813494
53Fanconi anemia pathway_Homo sapiens_hsa034600.70489995
54Estrogen signaling pathway_Homo sapiens_hsa049150.69628093
55mRNA surveillance pathway_Homo sapiens_hsa030150.64782371
56Tyrosine metabolism_Homo sapiens_hsa003500.63202704
57Renin-angiotensin system_Homo sapiens_hsa046140.62915446
58Renin secretion_Homo sapiens_hsa049240.62840456
59Gastric acid secretion_Homo sapiens_hsa049710.62762743
60Viral myocarditis_Homo sapiens_hsa054160.60357071
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59336647
62Arginine and proline metabolism_Homo sapiens_hsa003300.59323617
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58663940
64Cardiac muscle contraction_Homo sapiens_hsa042600.58509983
65Autoimmune thyroid disease_Homo sapiens_hsa053200.57437468
66Allograft rejection_Homo sapiens_hsa053300.55224754
67Serotonergic synapse_Homo sapiens_hsa047260.54512313
68Pancreatic secretion_Homo sapiens_hsa049720.52348657
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.50465988
70MAPK signaling pathway_Homo sapiens_hsa040100.50007365
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.49685009
72Retinol metabolism_Homo sapiens_hsa008300.48766226
73Bile secretion_Homo sapiens_hsa049760.48450344
74Long-term potentiation_Homo sapiens_hsa047200.47682312
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46994065
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45816266
77Graft-versus-host disease_Homo sapiens_hsa053320.44992629
78Gap junction_Homo sapiens_hsa045400.43203526
79Tight junction_Homo sapiens_hsa045300.40836783
80Purine metabolism_Homo sapiens_hsa002300.40789399
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40141618
82ECM-receptor interaction_Homo sapiens_hsa045120.39972891
83Cholinergic synapse_Homo sapiens_hsa047250.39962384
84Biosynthesis of amino acids_Homo sapiens_hsa012300.38315612
85Insulin secretion_Homo sapiens_hsa049110.37471796
86Oxytocin signaling pathway_Homo sapiens_hsa049210.37464298
87GABAergic synapse_Homo sapiens_hsa047270.36353197
88Basal transcription factors_Homo sapiens_hsa030220.31641651
89Choline metabolism in cancer_Homo sapiens_hsa052310.31034945
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30370231
91Acute myeloid leukemia_Homo sapiens_hsa052210.30083064
92Sulfur relay system_Homo sapiens_hsa041220.28146774
93Amphetamine addiction_Homo sapiens_hsa050310.27651006
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.21350062
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21322788
96Prolactin signaling pathway_Homo sapiens_hsa049170.21183733
97mTOR signaling pathway_Homo sapiens_hsa041500.21168449
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.19857557
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19534471
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18929067

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