ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chromosome condensation (GO:0030261)	9.09688384
2	DNA packaging (GO:0006323)	8.80139559
3	single strand break repair (GO:0000012)	8.56874829
4	sperm capacitation (GO:0048240)	8.38130475
5	spermatid development (GO:0007286)	8.18629856
6	protein targeting to Golgi (GO:0000042)	8.06427447
7	plasma membrane fusion (GO:0045026)	7.82474615
8	microtubule depolymerization (GO:0007019)	7.79849848
9	establishment of protein localization to Golgi (GO:0072600)	7.78573058
10	spermatid nucleus differentiation (GO:0007289)	7.64139028
11	protein polyglutamylation (GO:0018095)	7.47690355
12	retrograde transport, vesicle recycling within Golgi (GO:0000301)	7.45589052
13	sperm-egg recognition (GO:0035036)	7.29158207
14	axonemal dynein complex assembly (GO:0070286)	7.11354517
15	microtubule polymerization or depolymerization (GO:0031109)	6.96815093
16	multicellular organism reproduction (GO:0032504)	6.95863481
17	response to pheromone (GO:0019236)	6.92532196
18	binding of sperm to zona pellucida (GO:0007339)	6.73179196
19	rRNA methylation (GO:0031167)	6.71269227
20	reproduction (GO:0000003)	6.55361155
21	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.38560265
22	sexual reproduction (GO:0019953)	6.34934271
23	seminiferous tubule development (GO:0072520)	6.26174611
24	* spermatogenesis (GO:0007283)	6.20440814
25	* male gamete generation (GO:0048232)	6.18484976
26	centriole replication (GO:0007099)	6.11075995
27	calcium ion-dependent exocytosis (GO:0017156)	6.08413539
28	cell-cell recognition (GO:0009988)	6.02832525
29	phosphatidylethanolamine metabolic process (GO:0046337)	5.88898333
30	cilium or flagellum-dependent cell motility (GO:0001539)	5.87982155
31	motile cilium assembly (GO:0044458)	5.87245750
32	protein localization to Golgi apparatus (GO:0034067)	5.80111267
33	negative regulation of inclusion body assembly (GO:0090084)	5.80029299
34	* gamete generation (GO:0007276)	5.66816778
35	microtubule severing (GO:0051013)	5.59773844
36	rRNA modification (GO:0000154)	5.52240758
37	regulation of centriole replication (GO:0046599)	5.45775758
38	centriole assembly (GO:0098534)	5.38746987
39	single fertilization (GO:0007338)	5.35546846
40	RNA destabilization (GO:0050779)	5.30118891
41	regulation of cilium movement (GO:0003352)	5.01187428
42	germ cell development (GO:0007281)	4.69778635
43	cellular ketone body metabolic process (GO:0046950)	4.68842057
44	glomerular visceral epithelial cell development (GO:0072015)	4.67516901
45	regulation of transcription involved in cell fate commitment (GO:0060850)	4.57196251
46	* multicellular organismal reproductive process (GO:0048609)	4.53206010
47	regulation of Rab GTPase activity (GO:0032313)	4.52800678
48	positive regulation of Rab GTPase activity (GO:0032851)	4.52800678
49	fertilization (GO:0009566)	4.52257892
50	nucleus organization (GO:0006997)	4.43026746
51	glomerular epithelial cell development (GO:0072310)	4.36761888
52	epithelial cilium movement (GO:0003351)	4.36318418
53	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.33737815
54	chromatin silencing (GO:0006342)	4.33017746
55	cell wall macromolecule catabolic process (GO:0016998)	4.24179328
56	ketone body metabolic process (GO:1902224)	4.12447097
57	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.11082722
58	cell wall macromolecule metabolic process (GO:0044036)	3.98441684
59	regulation of inclusion body assembly (GO:0090083)	3.94003957
60	positive regulation of guanylate cyclase activity (GO:0031284)	3.92573939
61	microtubule nucleation (GO:0007020)	3.91335450
62	musculoskeletal movement (GO:0050881)	3.84457421
63	multicellular organismal movement (GO:0050879)	3.84457421
64	cilium movement (GO:0003341)	3.77554165
65	glycerol ether metabolic process (GO:0006662)	3.70719134
66	regulation of guanylate cyclase activity (GO:0031282)	3.60670926
67	positive regulation of endothelial cell differentiation (GO:0045603)	3.50191687
68	nucleosome disassembly (GO:0006337)	3.49226433
69	protein-DNA complex disassembly (GO:0032986)	3.49226433
70	homeostasis of number of cells within a tissue (GO:0048873)	3.45634712
71	ether metabolic process (GO:0018904)	3.41314095
72	organic cation transport (GO:0015695)	3.34772991
73	negative regulation of Rho protein signal transduction (GO:0035024)	3.32582099
74	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.29946275
75	polyamine biosynthetic process (GO:0006596)	3.19301510
76	axoneme assembly (GO:0035082)	3.18970632
77	nuclear pore complex assembly (GO:0051292)	3.13370907
78	intra-Golgi vesicle-mediated transport (GO:0006891)	3.11832651
79	cellular response to pH (GO:0071467)	3.11649371
80	multicellular organismal development (GO:0007275)	3.10924165
81	ventricular system development (GO:0021591)	3.04463438
82	response to acidic pH (GO:0010447)	3.03057487
83	regulation of microtubule-based movement (GO:0060632)	3.00615034
84	protein depolymerization (GO:0051261)	2.97902558
85	regulation of interleukin-13 production (GO:0032656)	2.94407955
86	membrane protein intracellular domain proteolysis (GO:0031293)	2.92193901
87	coenzyme catabolic process (GO:0009109)	2.89745055
88	negative regulation of gene expression, epigenetic (GO:0045814)	2.87357432
89	cell recognition (GO:0008037)	2.87147254
90	DNA conformation change (GO:0071103)	2.81784587
91	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.80385666
92	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.79064229
93	RNA localization (GO:0006403)	2.74839117
94	histone H3-K9 demethylation (GO:0033169)	2.73497072
95	regulation of ARF GTPase activity (GO:0032312)	2.73041296
96	piRNA metabolic process (GO:0034587)	2.68380460
97	NAD biosynthetic process (GO:0009435)	2.67204576
98	sperm motility (GO:0030317)	12.0128796
99	acrosome reaction (GO:0007340)	11.3183497
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.2622148

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.77713658
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.63946259
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.23455736
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.80097260
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.65716632
6	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34867142
7	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.34867142
8	CBP_20019798_ChIP-Seq_JUKART_Human	2.20964069
9	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.20964069
10	DROSHA_22980978_ChIP-Seq_HELA_Human	2.19361518
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13517993
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.12134616
13	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.06886462
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.97320714
15	RAC3_21632823_ChIP-Seq_H3396_Human	1.96804709
16	FUS_26573619_Chip-Seq_HEK293_Human	1.92213868
17	ERA_21632823_ChIP-Seq_H3396_Human	1.83450748
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.75809872
19	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.74839473
20	NANOG_20526341_ChIP-Seq_ESCs_Human	1.74561098
21	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.73542027
22	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.70777681
23	CTCF_27219007_Chip-Seq_Bcells_Human	1.67068992
24	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.65839487
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63570173
26	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.62794603
27	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.58253879
28	MYC_19829295_ChIP-Seq_ESCs_Human	1.57066932
29	TAF2_19829295_ChIP-Seq_ESCs_Human	1.54933733
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.53598582
31	BCOR_27268052_Chip-Seq_Bcells_Human	1.52760332
32	OCT4_20526341_ChIP-Seq_ESCs_Human	1.52584215
33	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.52554523
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51010805
35	BCL6_27268052_Chip-Seq_Bcells_Human	1.50527494
36	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.49747747
37	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.49718467
38	E2F1_20622854_ChIP-Seq_HELA_Human	1.49426693
39	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.49406214
40	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.49156817
41	RBPJ_21746931_ChIP-Seq_IB4_Human	1.47596477
42	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.46324551
43	CTCF_20526341_ChIP-Seq_ESCs_Human	1.45812764
44	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.44864257
45	ETV1_20927104_ChIP-Seq_GIST48_Human	1.42458010
46	PHF8_20622854_ChIP-Seq_HELA_Human	1.40051094
47	AR_25329375_ChIP-Seq_VCAP_Human	1.38725905
48	TP53_18474530_ChIP-ChIP_U2OS_Human	1.38599415
49	P68_20966046_ChIP-Seq_HELA_Human	1.37940554
50	SMC4_20622854_ChIP-Seq_HELA_Human	1.37674048
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37109056
52	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.36128084
53	ERG_20517297_ChIP-Seq_VCAP_Human	1.34970761
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34854152
55	TP63_22573176_ChIP-Seq_HFKS_Human	1.33572580
56	TBL1_22424771_ChIP-Seq_293T_Human	1.32595857
57	NFYB_21822215_ChIP-Seq_K562_Human	1.31890420
58	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.30910553
59	PHF8_20622853_ChIP-Seq_HELA_Human	1.30104505
60	P300_19829295_ChIP-Seq_ESCs_Human	1.29682824
61	P300_27268052_Chip-Seq_Bcells_Human	1.28248591
62	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.24074354
63	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.23576715
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22796283
65	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.22544579
66	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.22144015
67	ZNF274_21170338_ChIP-Seq_K562_Hela	1.21083560
68	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.20779700
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20723835
70	CEBPB_22108803_ChIP-Seq_LS180_Human	1.20652664
71	LXR_22292898_ChIP-Seq_THP-1_Human	1.19164463
72	NFYA_21822215_ChIP-Seq_K562_Human	1.18951362
73	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.18446485
74	RUNX_20019798_ChIP-Seq_JUKART_Human	1.16281506
75	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.15818935
76	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.14800358
77	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.13687440
78	STAT3_23295773_ChIP-Seq_U87_Human	1.13431731
79	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.13238819
80	SA1_27219007_Chip-Seq_Bcells_Human	1.11432158
81	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.10708352
82	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.09382584
83	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.08675088
84	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07404913
85	P53_21459846_ChIP-Seq_SAOS-2_Human	1.06535658
86	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06207301
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05831116
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05493573
89	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05058396
90	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05058396
91	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02897767
92	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02504186
93	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02232695
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.01218563
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00464997
96	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00343970
97	VDR_22108803_ChIP-Seq_LS180_Human	1.00252253
98	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.00239346
99	KLF4_19829295_ChIP-Seq_ESCs_Human	0.98479907
100	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.98266918

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	5.81774504
2	MP0005377_hearing/vestibular/ear_phenot	5.81774504
3	MP0003698_abnormal_male_reproductive	4.44407390
4	MP0005670_abnormal_white_adipose	4.11473569
5	MP0001929_abnormal_gametogenesis	3.89165021
6	MP0001348_abnormal_lacrimal_gland	3.37282837
7	MP0003646_muscle_fatigue	2.92462022
8	MP0002161_abnormal_fertility/fecundity	2.38934977
9	MP0000678_abnormal_parathyroid_gland	2.29585049
10	MP0005410_abnormal_fertilization	11.7087613
11	MP0001485_abnormal_pinna_reflex	1.89366263
12	MP0002210_abnormal_sex_determination	1.86736923
13	MP0003718_maternal_effect	1.82565960
14	MP0005379_endocrine/exocrine_gland_phen	1.81226419
15	MP0003011_delayed_dark_adaptation	1.75503493
16	MP0002132_abnormal_respiratory_system	1.74321327
17	MP0003879_abnormal_hair_cell	1.66888190
18	MP0005451_abnormal_body_composition	1.62242292
19	MP0001486_abnormal_startle_reflex	1.59171726
20	MP0001145_abnormal_male_reproductive	1.46744265
21	MP0005310_abnormal_salivary_gland	1.46409876
22	MP0000653_abnormal_sex_gland	1.43272104
23	MP0004742_abnormal_vestibular_system	1.34333531
24	MP0005083_abnormal_biliary_tract	1.31323764
25	MP0001765_abnormal_ion_homeostasis	1.28519181
26	MP0001968_abnormal_touch/_nociception	1.28030250
27	MP0005551_abnormal_eye_electrophysiolog	1.27060239
28	MP0002653_abnormal_ependyma_morphology	1.25878059
29	MP0002735_abnormal_chemical_nociception	1.23141071
30	MP0001963_abnormal_hearing_physiology	1.22907391
31	MP0002282_abnormal_trachea_morphology	1.14866683
32	MP0005423_abnormal_somatic_nervous	1.14547191
33	MP0001984_abnormal_olfaction	1.04660286
34	MP0002249_abnormal_larynx_morphology	1.04246359
35	MP0005253_abnormal_eye_physiology	1.02695055
36	MP0004859_abnormal_synaptic_plasticity	1.02568452
37	MP0000026_abnormal_inner_ear	1.02237303
38	MP0002234_abnormal_pharynx_morphology	0.99121355
39	MP0005395_other_phenotype	0.97762820
40	MP0002138_abnormal_hepatobiliary_system	0.97589961
41	MP0002127_abnormal_cardiovascular_syste	0.93185182
42	MP0005645_abnormal_hypothalamus_physiol	0.90351416
43	MP0001986_abnormal_taste_sensitivity	0.86771795
44	MP0001501_abnormal_sleep_pattern	0.86553607
45	MP0002229_neurodegeneration	0.86246823
46	MP0000534_abnormal_ureter_morphology	0.85901070
47	MP0002557_abnormal_social/conspecific_i	0.83261954
48	MP0001666_abnormal_nutrient_absorption	0.82805105
49	MP0002733_abnormal_thermal_nociception	0.82746294
50	MP0009115_abnormal_fat_cell	0.82734783
51	MP0009697_abnormal_copulation	0.82107190
52	MP0002067_abnormal_sensory_capabilities	0.81764409
53	MP0008877_abnormal_DNA_methylation	0.80405248
54	MP0008995_early_reproductive_senescence	0.78815677
55	MP0005666_abnormal_adipose_tissue	0.78696759
56	MP0005167_abnormal_blood-brain_barrier	0.73456517
57	MP0004085_abnormal_heartbeat	0.71008140
58	MP0002928_abnormal_bile_duct	0.69548456
59	MP0002272_abnormal_nervous_system	0.68630303
60	MP0000955_abnormal_spinal_cord	0.68323784
61	MP0008569_lethality_at_weaning	0.67460724
62	MP0009053_abnormal_anal_canal	0.66379104
63	MP0004510_myositis	0.65971528
64	MP0003045_fibrosis	0.63522963
65	MP0005636_abnormal_mineral_homeostasis	0.62866001
66	MP0000230_abnormal_systemic_arterial	0.62684141
67	MP0002734_abnormal_mechanical_nocicepti	0.60166569
68	MP0002572_abnormal_emotion/affect_behav	0.59886571
69	MP0001970_abnormal_pain_threshold	0.57625473
70	MP0010329_abnormal_lipoprotein_level	0.57494109
71	MP0004036_abnormal_muscle_relaxation	0.56769764
72	MP0010386_abnormal_urinary_bladder	0.56219459
73	MP0005332_abnormal_amino_acid	0.54940406
74	MP0005671_abnormal_response_to	0.54042693
75	MP0001905_abnormal_dopamine_level	0.51556919
76	MP0000681_abnormal_thyroid_gland	0.50791014
77	MP0002822_catalepsy	0.49814509
78	MP0009745_abnormal_behavioral_response	0.49638278
79	MP0001879_abnormal_lymphatic_vessel	0.49219100
80	MP0005375_adipose_tissue_phenotype	0.48006103
81	MP0005248_abnormal_Harderian_gland	0.47816309
82	MP0002136_abnormal_kidney_physiology	0.46858074
83	MP0002168_other_aberrant_phenotype	0.46774706
84	MP0009643_abnormal_urine_homeostasis	0.44613455
85	MP0001873_stomach_inflammation	0.42893079
86	MP0003950_abnormal_plasma_membrane	0.41700994
87	MP0005535_abnormal_body_temperature	0.41549055
88	MP0000470_abnormal_stomach_morphology	0.40210451
89	MP0003119_abnormal_digestive_system	0.40084986
90	MP0008872_abnormal_physiological_respon	0.38754593
91	MP0004782_abnormal_surfactant_physiolog	0.38563897
92	MP0001440_abnormal_grooming_behavior	0.37824697
93	MP0005647_abnormal_sex_gland	0.36960680
94	MP0000049_abnormal_middle_ear	0.36935022
95	MP0003635_abnormal_synaptic_transmissio	0.36805624
96	MP0008775_abnormal_heart_ventricle	0.36787650
97	MP0005391_vision/eye_phenotype	0.35674958
98	MP0003699_abnormal_female_reproductive	0.34942590
99	MP0003631_nervous_system_phenotype	0.34691918
100	MP0005595_abnormal_vascular_smooth	0.33706705

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.25162816
2	Absent/shortened dynein arms (HP:0200106)	6.52015615
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.52015615
4	Chronic hepatic failure (HP:0100626)	5.83028912
5	Tubulointerstitial nephritis (HP:0001970)	5.77452392
6	Abnormal respiratory motile cilium morphology (HP:0005938)	5.15873566
7	Abnormal respiratory epithelium morphology (HP:0012253)	5.15873566
8	Hyperkalemia (HP:0002153)	5.10974916
9	Asymmetric septal hypertrophy (HP:0001670)	4.66351921
10	Abnormal ciliary motility (HP:0012262)	4.64838441
11	Nasal polyposis (HP:0100582)	4.59261541
12	Attenuation of retinal blood vessels (HP:0007843)	4.54585868
13	Bony spicule pigmentary retinopathy (HP:0007737)	4.47931576
14	Abnormal respiratory motile cilium physiology (HP:0012261)	4.43529887
15	Cone-rod dystrophy (HP:0000548)	4.37244334
16	Male infertility (HP:0003251)	4.30557605
17	Abnormality of macular pigmentation (HP:0008002)	4.15184629
18	Resting tremor (HP:0002322)	4.14262394
19	Amelogenesis imperfecta (HP:0000705)	4.13984493
20	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.07111472
21	Infertility (HP:0000789)	4.00512890
22	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.95621319
23	Abnormality of the nasal mucosa (HP:0000433)	3.70189783
24	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.60236030
25	Menstrual irregularities (HP:0000858)	3.56313828
26	Progressive sensorineural hearing impairment (HP:0000408)	3.55089096
27	Hypoalphalipoproteinemia (HP:0003233)	3.53438092
28	Enlarged epiphyses (HP:0010580)	3.52563190
29	Abnormality of dental color (HP:0011073)	3.45204556
30	Abnormal rod and cone electroretinograms (HP:0008323)	3.41552267
31	Impulsivity (HP:0100710)	3.37422033
32	Hypoplasia of the thymus (HP:0000778)	3.20228225
33	Renovascular hypertension (HP:0100817)	3.14343708
34	Abnormal spermatogenesis (HP:0008669)	3.10812367
35	Progressive cerebellar ataxia (HP:0002073)	3.07822789
36	Facial shape deformation (HP:0011334)	3.04064784
37	Potter facies (HP:0002009)	3.04064784
38	Portal hypertension (HP:0001409)	2.94801344
39	Generalized aminoaciduria (HP:0002909)	2.94195535
40	Abnormality of the costochondral junction (HP:0000919)	2.90462794
41	Azoospermia (HP:0000027)	2.88524670
42	Postural instability (HP:0002172)	2.85812040
43	Stage 5 chronic kidney disease (HP:0003774)	2.85459089
44	Truncal obesity (HP:0001956)	2.79008247
45	Abnormality of the aortic arch (HP:0012303)	2.78797230
46	Abnormality of potassium homeostasis (HP:0011042)	2.76329598
47	Abnormality of the hepatic vasculature (HP:0006707)	2.70918765
48	Tubulointerstitial abnormality (HP:0001969)	2.62507366
49	Abnormal urine output (HP:0012590)	2.60641232
50	Congenital sensorineural hearing impairment (HP:0008527)	2.60268643
51	Nephronophthisis (HP:0000090)	2.55551908
52	Insulin-resistant diabetes mellitus (HP:0000831)	2.51387648
53	Hyponatremia (HP:0002902)	2.46856071
54	Bell-shaped thorax (HP:0001591)	2.46163135
55	Hyperuricemia (HP:0002149)	2.43977010
56	Increased purine levels (HP:0004368)	2.43977010
57	Polydipsia (HP:0001959)	2.31134202
58	Abnormal drinking behavior (HP:0030082)	2.31134202
59	Rhinitis (HP:0012384)	2.25610001
60	Abnormality of renal excretion (HP:0011036)	2.24999024
61	Polyuria (HP:0000103)	2.24484096
62	Hypoplastic ischia (HP:0003175)	2.24145957
63	Widely patent fontanelles and sutures (HP:0004492)	2.23583125
64	Unilateral renal agenesis (HP:0000122)	2.21783734
65	Focal segmental glomerulosclerosis (HP:0000097)	2.19807351
66	Abnormality of the renal medulla (HP:0100957)	2.12192355
67	Chronic bronchitis (HP:0004469)	2.12138368
68	Osteomalacia (HP:0002749)	2.10829460
69	Hypophosphatemic rickets (HP:0004912)	2.10190119
70	Bronchiectasis (HP:0002110)	2.10088168
71	Progressive hearing impairment (HP:0001730)	2.09889302
72	Recurrent corneal erosions (HP:0000495)	2.04699692
73	Abnormality of chloride homeostasis (HP:0011422)	2.03110464
74	Intellectual disability, moderate (HP:0002342)	2.00796314
75	Abnormality of the ischium (HP:0003174)	1.99353360
76	Hypergonadotropic hypogonadism (HP:0000815)	1.94669685
77	Pigmentary retinal degeneration (HP:0001146)	1.92070211
78	Congenital malformation of the right heart (HP:0011723)	1.91690725
79	Double outlet right ventricle (HP:0001719)	1.91690725
80	Subcapsular cataract (HP:0000523)	1.91377683
81	Abnormality of the parathyroid morphology (HP:0011766)	1.89431199
82	Pendular nystagmus (HP:0012043)	1.89350370
83	Glomerulosclerosis (HP:0000096)	1.87897178
84	Renal dysplasia (HP:0000110)	1.85722848
85	Abnormal albumin level (HP:0012116)	1.84540203
86	Hypoalbuminemia (HP:0003073)	1.84540203
87	Abnormality of sodium homeostasis (HP:0010931)	1.84421207
88	Photophobia (HP:0000613)	1.81661553
89	Abnormality of DNA repair (HP:0003254)	1.76989228
90	Ventricular tachycardia (HP:0004756)	1.75596743
91	Decreased central vision (HP:0007663)	1.74788507
92	Optic nerve hypoplasia (HP:0000609)	1.73923314
93	Cerebellar dysplasia (HP:0007033)	1.72439414
94	Myokymia (HP:0002411)	1.72242277
95	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.70929622
96	Peritonitis (HP:0002586)	1.70561318
97	Abnormality of purine metabolism (HP:0004352)	1.70185250
98	Bradycardia (HP:0001662)	1.68863641
99	Scotoma (HP:0000575)	1.66894131
100	Hypolipoproteinemia (HP:0010981)	1.66152854

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.80999703
2	INSRR	5.00594505
3	TESK1	4.38789001
4	BRD4	3.97588226
5	PLK2	3.18017912
6	STK38	2.93137568
7	PNCK	2.93039706
8	MAP4K2	2.79371965
9	DDR2	2.55942529
10	MAPK15	2.51270613
11	CAMK1G	2.43271696
12	MST1R	2.13352908
13	PIK3CG	2.04855095
14	TAOK3	1.98650676
15	MAP3K11	1.96415571
16	STK38L	1.81791155
17	WNK4	1.81542535
18	PRKD3	1.78660011
19	WNK1	1.72034786
20	PDK1	1.56705286
21	CDK12	1.55928457
22	TYRO3	1.53050318
23	PDPK1	1.43455583
24	MAP3K13	1.35214128
25	NEK6	1.27250988
26	PTK2B	1.18953221
27	TIE1	1.06588132
28	MAP4K1	1.00836098
29	CAMK1D	0.99920851
30	RIPK4	0.96281246
31	DYRK1B	0.91859768
32	CDK7	0.78573415
33	KDR	0.78091394
34	TESK2	0.70818943
35	STK39	0.68633483
36	PRKG2	0.68205417
37	TXK	0.65818472
38	AKT3	0.64040046
39	SIK2	0.62970345
40	MAP2K2	0.62918347
41	BLK	0.58461828
42	NME1	0.56578276
43	MAP3K1	0.55266301
44	OXSR1	0.54864382
45	MAP3K9	0.54495807
46	CASK	0.54050157
47	NEK2	0.52499915
48	CAMK1	0.52336611
49	PRKG1	0.51431435
50	LATS2	0.51038444
51	ZAK	0.50477065
52	PRKAA2	0.48336719
53	PINK1	0.46518497
54	KSR2	0.45702298
55	BRAF	0.43848167
56	FRK	0.40973360
57	RPS6KA2	0.40220980
58	CDK3	0.39651878
59	CAMK4	0.39634665
60	MAP3K8	0.39251759
61	RPS6KA1	0.36403724
62	MARK3	0.36274535
63	PRKCZ	0.34516339
64	SGK1	0.34300515
65	MUSK	0.34091353
66	SGK223	0.33835801
67	SGK494	0.33835801
68	GSK3B	0.33338257
69	MAP3K7	0.32930106
70	CDK1	0.32757740
71	MAPK1	0.32721356
72	CDK2	0.32430568
73	MARK1	0.32290658
74	ADRBK2	0.30396815
75	ROCK1	0.29487815
76	ICK	0.28374394
77	MAPK8	0.26796572
78	LATS1	0.26131716
79	MET	0.25983747
80	RPS6KA6	0.23706371
81	RPS6KC1	0.22556047
82	RPS6KL1	0.22556047
83	MAP3K2	0.21981011
84	PRKCB	0.21965498
85	UHMK1	0.21835474
86	NTRK3	0.21261135
87	MTOR	0.18923929
88	ZAP70	0.18431354
89	PRKCG	0.17917656
90	MAPK14	0.16419121
91	PRKCH	0.14840047
92	SGK2	0.14692168
93	CDK4	0.14063027
94	BMPR1B	0.13889359
95	PRKCQ	0.12236345
96	AKT1	0.10899819
97	CHEK1	0.10663270
98	MAPK10	0.10129836
99	PASK	0.10097646
100	RIPK1	0.10074346

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	7.44664636
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.91266560
3	Olfactory transduction_Homo sapiens_hsa04740	4.01432804
4	Butanoate metabolism_Homo sapiens_hsa00650	2.24886159
5	Phototransduction_Homo sapiens_hsa04744	2.17446433
6	Taste transduction_Homo sapiens_hsa04742	1.99530930
7	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.89446938
8	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.88149400
9	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.87465876
10	RNA transport_Homo sapiens_hsa03013	1.76255231
11	Antigen processing and presentation_Homo sapiens_hsa04612	1.59694696
12	Fatty acid metabolism_Homo sapiens_hsa01212	1.57127665
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.52755681
14	Type II diabetes mellitus_Homo sapiens_hsa04930	1.51017314
15	Fatty acid degradation_Homo sapiens_hsa00071	1.48340367
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.43834642
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.42240953
18	ABC transporters_Homo sapiens_hsa02010	1.39750065
19	Salivary secretion_Homo sapiens_hsa04970	1.36034810
20	Allograft rejection_Homo sapiens_hsa05330	1.35434533
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.35419478
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.25971113
23	Nicotine addiction_Homo sapiens_hsa05033	1.21977185
24	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.20633412
25	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.19614517
26	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.18475870
27	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.10344467
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.10341991
29	Calcium signaling pathway_Homo sapiens_hsa04020	1.09614414
30	Protein digestion and absorption_Homo sapiens_hsa04974	1.09611341
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.05972271
32	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.04364865
33	Morphine addiction_Homo sapiens_hsa05032	1.03301838
34	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.01358757
35	Fanconi anemia pathway_Homo sapiens_hsa03460	0.99180287
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.96580673
37	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.95969047
38	Viral myocarditis_Homo sapiens_hsa05416	0.95949775
39	Phenylalanine metabolism_Homo sapiens_hsa00360	0.95085726
40	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.88446550
41	Bile secretion_Homo sapiens_hsa04976	0.87301172
42	Endocytosis_Homo sapiens_hsa04144	0.86276621
43	Arginine and proline metabolism_Homo sapiens_hsa00330	0.85447456
44	Circadian entrainment_Homo sapiens_hsa04713	0.85089758
45	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.82468358
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.81789155
47	PPAR signaling pathway_Homo sapiens_hsa03320	0.79708792
48	Arginine biosynthesis_Homo sapiens_hsa00220	0.78575905
49	Influenza A_Homo sapiens_hsa05164	0.74259165
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.73607654
51	Mineral absorption_Homo sapiens_hsa04978	0.72960891
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.72869827
53	Renin secretion_Homo sapiens_hsa04924	0.72302176
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67818502
55	Retinol metabolism_Homo sapiens_hsa00830	0.67630214
56	cAMP signaling pathway_Homo sapiens_hsa04024	0.67242304
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.66725821
58	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.62726783
59	Insulin secretion_Homo sapiens_hsa04911	0.61186805
60	Oocyte meiosis_Homo sapiens_hsa04114	0.61118139
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61108328
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.61100741
63	Serotonergic synapse_Homo sapiens_hsa04726	0.60261071
64	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.58632941
65	Pancreatic secretion_Homo sapiens_hsa04972	0.56810918
66	MAPK signaling pathway_Homo sapiens_hsa04010	0.56052750
67	VEGF signaling pathway_Homo sapiens_hsa04370	0.54989333
68	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.54903672
69	Purine metabolism_Homo sapiens_hsa00230	0.51248620
70	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.50287154
71	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.49611607
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.49069718
73	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.47829782
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.44900511
75	Gastric acid secretion_Homo sapiens_hsa04971	0.44801752
76	Primary immunodeficiency_Homo sapiens_hsa05340	0.44518630
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44243024
78	GABAergic synapse_Homo sapiens_hsa04727	0.41388949
79	Tyrosine metabolism_Homo sapiens_hsa00350	0.41215419
80	Basal transcription factors_Homo sapiens_hsa03022	0.40415952
81	ECM-receptor interaction_Homo sapiens_hsa04512	0.40322126
82	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.39638233
83	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.36842867
84	Estrogen signaling pathway_Homo sapiens_hsa04915	0.36012046
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.32517601
86	Cholinergic synapse_Homo sapiens_hsa04725	0.32459590
87	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.31937671
88	Huntingtons disease_Homo sapiens_hsa05016	0.30873562
89	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.27226673
90	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.27087651
91	Herpes simplex infection_Homo sapiens_hsa05168	0.25602168
92	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.25234431
93	Amphetamine addiction_Homo sapiens_hsa05031	0.23727074
94	Long-term potentiation_Homo sapiens_hsa04720	0.22123298
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.21869357
96	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.21772793
97	Tight junction_Homo sapiens_hsa04530	0.19219847
98	Renin-angiotensin system_Homo sapiens_hsa04614	0.18515244
99	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.18248112
100	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.18167164

SPATA31A6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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