ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	7.13767688
2	acrosome reaction (GO:0007340)	6.90877656
3	sperm motility (GO:0030317)	6.66112380
4	fusion of sperm to egg plasma membrane (GO:0007342)	5.45074388
5	multicellular organism reproduction (GO:0032504)	5.38146943
6	cellular ketone body metabolic process (GO:0046950)	5.28737618
7	protein polyglutamylation (GO:0018095)	4.92253280
8	ketone body metabolic process (GO:1902224)	4.89736021
9	spermatid development (GO:0007286)	4.87426282
10	establishment of protein localization to Golgi (GO:0072600)	4.56822443
11	sperm-egg recognition (GO:0035036)	4.45040700
12	single strand break repair (GO:0000012)	4.42360174
13	protein targeting to Golgi (GO:0000042)	4.38610094
14	regulation of cilium movement (GO:0003352)	4.33420722
15	plasma membrane fusion (GO:0045026)	4.31180247
16	piRNA metabolic process (GO:0034587)	4.18227302
17	reproduction (GO:0000003)	4.18127908
18	epithelial cilium movement (GO:0003351)	4.18005842
19	calcium ion-dependent exocytosis (GO:0017156)	4.15734832
20	behavioral response to nicotine (GO:0035095)	4.09408230
21	indole-containing compound catabolic process (GO:0042436)	4.04090087
22	indolalkylamine catabolic process (GO:0046218)	4.04090087
23	tryptophan catabolic process (GO:0006569)	4.04090087
24	rRNA methylation (GO:0031167)	3.85521331
25	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.84960778
26	cornea development in camera-type eye (GO:0061303)	3.77906397
27	kynurenine metabolic process (GO:0070189)	3.75110409
28	microtubule depolymerization (GO:0007019)	3.74988924
29	sperm capacitation (GO:0048240)	3.74337581
30	spermatid nucleus differentiation (GO:0007289)	3.70657384
31	negative regulation of mast cell activation (GO:0033004)	3.69718871
32	cell-cell recognition (GO:0009988)	3.64140108
33	cilium or flagellum-dependent cell motility (GO:0001539)	3.61559119
34	protein K11-linked deubiquitination (GO:0035871)	3.57146028
35	cilium movement (GO:0003341)	3.53697363
36	fucose catabolic process (GO:0019317)	3.53011799
37	L-fucose metabolic process (GO:0042354)	3.53011799
38	L-fucose catabolic process (GO:0042355)	3.53011799
39	axonemal dynein complex assembly (GO:0070286)	3.52599942
40	DNA methylation involved in gamete generation (GO:0043046)	3.50425922
41	protein localization to Golgi apparatus (GO:0034067)	3.48789167
42	axoneme assembly (GO:0035082)	3.47702215
43	indolalkylamine metabolic process (GO:0006586)	3.47667318
44	* spermatogenesis (GO:0007283)	3.43156086
45	* male gamete generation (GO:0048232)	3.42744306
46	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.39307073
47	rRNA modification (GO:0000154)	3.38212138
48	phosphatidylethanolamine metabolic process (GO:0046337)	3.37332252
49	NAD biosynthetic process (GO:0009435)	3.37110153
50	male meiosis I (GO:0007141)	3.36351575
51	single fertilization (GO:0007338)	3.34965327
52	tryptophan metabolic process (GO:0006568)	3.34310988
53	regulation of hexokinase activity (GO:1903299)	3.33429953
54	regulation of glucokinase activity (GO:0033131)	3.33429953
55	microtubule polymerization or depolymerization (GO:0031109)	3.28817954
56	regulation of microtubule-based movement (GO:0060632)	3.28206397
57	detection of light stimulus involved in sensory perception (GO:0050962)	3.26557680
58	detection of light stimulus involved in visual perception (GO:0050908)	3.26557680
59	centriole replication (GO:0007099)	3.24522926
60	binding of sperm to zona pellucida (GO:0007339)	3.20453456
61	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.15523390
62	* gamete generation (GO:0007276)	3.14146481
63	RNA destabilization (GO:0050779)	3.12039569
64	seminiferous tubule development (GO:0072520)	3.10023793
65	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.09013418
66	nephron epithelium morphogenesis (GO:0072088)	3.07308094
67	nephron tubule morphogenesis (GO:0072078)	3.07308094
68	organic cation transport (GO:0015695)	3.05936398
69	DNA packaging (GO:0006323)	3.04446127
70	amine catabolic process (GO:0009310)	3.03150040
71	cellular biogenic amine catabolic process (GO:0042402)	3.03150040
72	nonmotile primary cilium assembly (GO:0035058)	3.01727345
73	chromosome condensation (GO:0030261)	2.96962362
74	cilium morphogenesis (GO:0060271)	2.92418140
75	male meiosis (GO:0007140)	2.88581673
76	photoreceptor cell maintenance (GO:0045494)	2.86393288
77	cilium organization (GO:0044782)	2.84217097
78	fertilization (GO:0009566)	2.83412897
79	platelet dense granule organization (GO:0060155)	2.80314827
80	cilium assembly (GO:0042384)	2.78973807
81	coenzyme catabolic process (GO:0009109)	2.77546229
82	germ cell development (GO:0007281)	2.76378604
83	positive regulation of Rab GTPase activity (GO:0032851)	2.75728433
84	regulation of Rab GTPase activity (GO:0032313)	2.75728433
85	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.73685922
86	auditory receptor cell stereocilium organization (GO:0060088)	2.73284325
87	microtubule severing (GO:0051013)	2.71070013
88	indole-containing compound metabolic process (GO:0042430)	2.68566685
89	primary amino compound metabolic process (GO:1901160)	2.67650768
90	retinal cone cell development (GO:0046549)	2.66821144
91	regulation of meiosis I (GO:0060631)	2.64602974
92	DNA deamination (GO:0045006)	2.63687241
93	regulation of transcription involved in cell fate commitment (GO:0060850)	2.63106814
94	meiosis I (GO:0007127)	2.62332960
95	synapsis (GO:0007129)	2.62067864
96	cell wall macromolecule metabolic process (GO:0044036)	2.61381917
97	neuronal action potential (GO:0019228)	2.61164263
98	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.61016633
99	spinal cord motor neuron differentiation (GO:0021522)	2.57623280
100	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.56952603

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.57598946
2	VDR_22108803_ChIP-Seq_LS180_Human	2.96549386
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.79255453
4	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.55116519
5	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.32272143
6	FUS_26573619_Chip-Seq_HEK293_Human	2.29530471
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.25248923
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.23529312
9	ER_23166858_ChIP-Seq_MCF-7_Human	2.13664691
10	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.09518698
11	CBP_20019798_ChIP-Seq_JUKART_Human	2.09518698
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.08320603
13	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.06330527
14	P300_19829295_ChIP-Seq_ESCs_Human	2.05076360
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.02532906
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.00532063
17	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.91123759
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86331158
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.85469011
20	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.84838905
21	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.84838905
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83699594
23	AR_25329375_ChIP-Seq_VCAP_Human	1.75639513
24	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.75065790
25	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.72458829
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.68317730
27	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.64260643
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.59435353
29	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.56272991
30	STAT3_23295773_ChIP-Seq_U87_Human	1.55092183
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52995593
32	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.52511968
33	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.52349138
34	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.52138776
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49744671
36	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45083414
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45083414
38	TCF4_23295773_ChIP-Seq_U87_Human	1.42276572
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.41963888
40	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.41862025
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41488140
42	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.41170194
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40606391
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40606391
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40039273
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.39742174
47	EWS_26573619_Chip-Seq_HEK293_Human	1.39703110
48	ERA_21632823_ChIP-Seq_H3396_Human	1.37147591
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35680394
50	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.35623340
51	BCAT_22108803_ChIP-Seq_LS180_Human	1.33762926
52	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.32546917
53	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29977145
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29922237
55	MYC_19829295_ChIP-Seq_ESCs_Human	1.29597578
56	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.28678486
57	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28266013
58	HOXB7_26014856_ChIP-Seq_BT474_Human	1.27236635
59	NANOG_20526341_ChIP-Seq_ESCs_Human	1.26700978
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.26615290
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.25767679
62	NCOR_22424771_ChIP-Seq_293T_Human	1.24723598
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.24713556
64	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.24323560
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23585713
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21779979
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20754473
68	DROSHA_22980978_ChIP-Seq_HELA_Human	1.18996639
69	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.18996226
70	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18642493
71	TAF2_19829295_ChIP-Seq_ESCs_Human	1.18603118
72	AR_21572438_ChIP-Seq_LNCaP_Human	1.17769283
73	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17539519
74	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.17058380
75	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.16545460
76	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15921537
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14864897
78	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.14569138
79	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.13198197
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12709022
81	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.11872469
82	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.11062655
83	CDX2_22108803_ChIP-Seq_LS180_Human	1.10415362
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10339334
85	ETV1_20927104_ChIP-Seq_GIST48_Human	1.10327998
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09673107
87	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09533061
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09274050
89	AR_20517297_ChIP-Seq_VCAP_Human	1.08896142
90	PHF8_20622853_ChIP-Seq_HELA_Human	1.05854066
91	OCT4_20526341_ChIP-Seq_ESCs_Human	1.05522818
92	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05492439
93	RBPJ_21746931_ChIP-Seq_IB4_Human	1.04349270
94	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.04238776
95	TBL1_22424771_ChIP-Seq_293T_Human	1.03152817
96	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.01812839
97	NFYB_21822215_ChIP-Seq_K562_Human	1.01774516
98	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.01538748
99	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99552341
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99472913

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	5.50577239
2	MP0008877_abnormal_DNA_methylation	3.20622627
3	MP0003646_muscle_fatigue	2.91390943
4	MP0002638_abnormal_pupillary_reflex	2.64198049
5	MP0003878_abnormal_ear_physiology	2.58336569
6	MP0005377_hearing/vestibular/ear_phenot	2.58336569
7	MP0005551_abnormal_eye_electrophysiolog	2.39296291
8	MP0003698_abnormal_male_reproductive	2.24252704
9	MP0006292_abnormal_olfactory_placode	2.18218658
10	MP0001968_abnormal_touch/_nociception	2.16869353
11	MP0008875_abnormal_xenobiotic_pharmacok	2.08255292
12	MP0005645_abnormal_hypothalamus_physiol	2.00410294
13	MP0003195_calcinosis	1.98966640
14	MP0001929_abnormal_gametogenesis	1.97994606
15	MP0003011_delayed_dark_adaptation	1.95685453
16	MP0003787_abnormal_imprinting	1.94254015
17	MP0005253_abnormal_eye_physiology	1.92745510
18	MP0000569_abnormal_digit_pigmentation	1.92069542
19	MP0005670_abnormal_white_adipose	1.86812800
20	MP0001984_abnormal_olfaction	1.82276795
21	MP0001348_abnormal_lacrimal_gland	1.79953359
22	MP0002735_abnormal_chemical_nociception	1.79078880
23	MP0002102_abnormal_ear_morphology	1.77806297
24	MP0009046_muscle_twitch	1.77394539
25	MP0002876_abnormal_thyroid_physiology	1.71083314
26	MP0005379_endocrine/exocrine_gland_phen	1.69386622
27	MP0001486_abnormal_startle_reflex	1.69086158
28	MP0009745_abnormal_behavioral_response	1.67437923
29	MP0006072_abnormal_retinal_apoptosis	1.64761969
30	MP0008872_abnormal_physiological_respon	1.58545821
31	MP0003880_abnormal_central_pattern	1.57186625
32	MP0005084_abnormal_gallbladder_morpholo	1.54439250
33	MP0004742_abnormal_vestibular_system	1.53971100
34	MP0001485_abnormal_pinna_reflex	1.53649530
35	MP0002837_dystrophic_cardiac_calcinosis	1.50669160
36	MP0002272_abnormal_nervous_system	1.50149591
37	MP0002938_white_spotting	1.46698558
38	MP0003718_maternal_effect	1.43926352
39	MP0001501_abnormal_sleep_pattern	1.42862113
40	MP0002736_abnormal_nociception_after	1.41323568
41	MP0002928_abnormal_bile_duct	1.35499408
42	MP0002160_abnormal_reproductive_system	1.34434831
43	MP0006276_abnormal_autonomic_nervous	1.33816153
44	MP0004147_increased_porphyrin_level	1.31833432
45	MP0000372_irregular_coat_pigmentation	1.31604002
46	MP0005389_reproductive_system_phenotype	1.30273147
47	MP0008789_abnormal_olfactory_epithelium	1.28889982
48	MP0002138_abnormal_hepatobiliary_system	1.28157900
49	MP0005310_abnormal_salivary_gland	1.26965594
50	MP0005646_abnormal_pituitary_gland	1.26085338
51	MP0001970_abnormal_pain_threshold	1.24602864
52	MP0005167_abnormal_blood-brain_barrier	1.22828485
53	MP0002210_abnormal_sex_determination	1.21652949
54	MP0002234_abnormal_pharynx_morphology	1.20717844
55	MP0002572_abnormal_emotion/affect_behav	1.19666693
56	MP0010386_abnormal_urinary_bladder	1.18945090
57	MP0002733_abnormal_thermal_nociception	1.18181790
58	MP0004043_abnormal_pH_regulation	1.16357054
59	MP0002557_abnormal_social/conspecific_i	1.15811528
60	MP0004885_abnormal_endolymph	1.15800909
61	MP0001919_abnormal_reproductive_system	1.14866527
62	MP0000427_abnormal_hair_cycle	1.12586680
63	MP0004142_abnormal_muscle_tone	1.10708306
64	MP0002161_abnormal_fertility/fecundity	1.09008371
65	MP0001986_abnormal_taste_sensitivity	1.07458369
66	MP0002229_neurodegeneration	1.07414871
67	MP0001905_abnormal_dopamine_level	1.03939248
68	MP0004133_heterotaxia	1.03706970
69	MP0005174_abnormal_tail_pigmentation	1.02878704
70	MP0003136_yellow_coat_color	1.02343661
71	MP0002064_seizures	0.99743612
72	MP0000653_abnormal_sex_gland	0.99583255
73	MP0002067_abnormal_sensory_capabilities	0.96885249
74	MP0002653_abnormal_ependyma_morphology	0.96770049
75	MP0001529_abnormal_vocalization	0.95713752
76	MP0002822_catalepsy	0.95451806
77	MP0002254_reproductive_system_inflammat	0.95035453
78	MP0005394_taste/olfaction_phenotype	0.95018267
79	MP0005499_abnormal_olfactory_system	0.95018267
80	MP0001324_abnormal_eye_pigmentation	0.93580395
81	MP0001145_abnormal_male_reproductive	0.93208932
82	MP0001963_abnormal_hearing_physiology	0.92328738
83	MP0002163_abnormal_gland_morphology	0.90753013
84	MP0004924_abnormal_behavior	0.90610730
85	MP0005386_behavior/neurological_phenoty	0.90610730
86	MP0002734_abnormal_mechanical_nocicepti	0.90207196
87	MP0005423_abnormal_somatic_nervous	0.87622573
88	MP0000026_abnormal_inner_ear	0.86546097
89	MP0000230_abnormal_systemic_arterial	0.85950168
90	MP0000631_abnormal_neuroendocrine_gland	0.85196127
91	MP0005195_abnormal_posterior_eye	0.84754574
92	MP0000015_abnormal_ear_pigmentation	0.83166581
93	MP0002063_abnormal_learning/memory/cond	0.80887563
94	MP0002693_abnormal_pancreas_physiology	0.78905360
95	MP0003635_abnormal_synaptic_transmissio	0.78273198
96	MP0001765_abnormal_ion_homeostasis	0.77589271
97	MP0002282_abnormal_trachea_morphology	0.77585168
98	MP0003137_abnormal_impulse_conducting	0.76975923
99	MP0008775_abnormal_heart_ventricle	0.76352375
100	MP0005332_abnormal_amino_acid	0.76146663

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.34317349
2	Attenuation of retinal blood vessels (HP:0007843)	4.29366257
3	Severe visual impairment (HP:0001141)	4.11157011
4	Pancreatic fibrosis (HP:0100732)	3.84377188
5	Nephronophthisis (HP:0000090)	3.81231325
6	True hermaphroditism (HP:0010459)	3.76404973
7	Abnormal rod and cone electroretinograms (HP:0008323)	3.70181040
8	Congenital stationary night blindness (HP:0007642)	3.68264850
9	Chronic hepatic failure (HP:0100626)	3.53006821
10	Bony spicule pigmentary retinopathy (HP:0007737)	3.43793801
11	Abnormality of midbrain morphology (HP:0002418)	3.41500955
12	Molar tooth sign on MRI (HP:0002419)	3.41500955
13	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.33448282
14	Absent/shortened dynein arms (HP:0200106)	3.33448282
15	Abnormality of the renal medulla (HP:0100957)	3.32553331
16	Pendular nystagmus (HP:0012043)	3.10505979
17	Type II lissencephaly (HP:0007260)	3.07355608
18	Tubular atrophy (HP:0000092)	3.06693176
19	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.04471493
20	Hypoplasia of the fovea (HP:0007750)	3.04471493
21	Polydipsia (HP:0001959)	2.90639915
22	Abnormal drinking behavior (HP:0030082)	2.90639915
23	Hyperventilation (HP:0002883)	2.90335257
24	Abnormality of the renal cortex (HP:0011035)	2.89568773
25	Abnormality of macular pigmentation (HP:0008002)	2.83085593
26	Decreased central vision (HP:0007663)	2.78339296
27	Abnormal ciliary motility (HP:0012262)	2.76226711
28	Abnormal respiratory epithelium morphology (HP:0012253)	2.74079211
29	Abnormal respiratory motile cilium morphology (HP:0005938)	2.74079211
30	Cystic liver disease (HP:0006706)	2.67108361
31	Medial flaring of the eyebrow (HP:0010747)	2.59727825
32	Optic nerve hypoplasia (HP:0000609)	2.57745389
33	Abnormality of the fovea (HP:0000493)	2.56463864
34	Polyuria (HP:0000103)	2.55570012
35	Congenital sensorineural hearing impairment (HP:0008527)	2.52487361
36	Sclerocornea (HP:0000647)	2.50570743
37	Large for gestational age (HP:0001520)	2.47915584
38	Azoospermia (HP:0000027)	2.46692771
39	Abnormal respiratory motile cilium physiology (HP:0012261)	2.44189920
40	Tubulointerstitial nephritis (HP:0001970)	2.44050310
41	Progressive cerebellar ataxia (HP:0002073)	2.40031246
42	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.37590193
43	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.34354512
44	Abnormal urine output (HP:0012590)	2.34321085
45	Abnormal biliary tract physiology (HP:0012439)	2.33508355
46	Bile duct proliferation (HP:0001408)	2.33508355
47	Increased corneal curvature (HP:0100692)	2.32267565
48	Keratoconus (HP:0000563)	2.32267565
49	Cerebellar dysplasia (HP:0007033)	2.32055327
50	Lissencephaly (HP:0001339)	2.25946318
51	Anencephaly (HP:0002323)	2.25782851
52	Abolished electroretinogram (ERG) (HP:0000550)	2.22985976
53	Hyperkalemia (HP:0002153)	2.21100140
54	Gait imbalance (HP:0002141)	2.16665459
55	Congenital primary aphakia (HP:0007707)	2.11338832
56	Gaze-evoked nystagmus (HP:0000640)	2.08119817
57	Occipital encephalocele (HP:0002085)	2.07994696
58	Abnormality of renal excretion (HP:0011036)	2.07798662
59	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.06992990
60	Inability to walk (HP:0002540)	2.06168478
61	Decreased circulating renin level (HP:0003351)	2.05912469
62	Amelogenesis imperfecta (HP:0000705)	2.04478575
63	Abnormal spermatogenesis (HP:0008669)	2.01037172
64	Male pseudohermaphroditism (HP:0000037)	2.00367634
65	Tubulointerstitial abnormality (HP:0001969)	1.99773320
66	Aplasia/hypoplasia of the uterus (HP:0008684)	1.99378257
67	Aplasia/Hypoplasia of the macula (HP:0008059)	1.98490496
68	Abnormality of dental color (HP:0011073)	1.96835069
69	Abnormality of the pons (HP:0007361)	1.93194771
70	Nephrogenic diabetes insipidus (HP:0009806)	1.92447223
71	Congenital hepatic fibrosis (HP:0002612)	1.91454790
72	Intestinal atresia (HP:0011100)	1.90879364
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.89421005
74	Photophobia (HP:0000613)	1.85686160
75	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.84936225
76	Genital tract atresia (HP:0001827)	1.84066496
77	Stage 5 chronic kidney disease (HP:0003774)	1.83813979
78	Absent speech (HP:0001344)	1.81444291
79	Hypoplastic ischia (HP:0003175)	1.79523386
80	Hemiparesis (HP:0001269)	1.78577455
81	Hypoplasia of the uterus (HP:0000013)	1.78150911
82	Optic disc pallor (HP:0000543)	1.77167962
83	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.76798784
84	Vaginal atresia (HP:0000148)	1.74893111
85	Chorioretinal atrophy (HP:0000533)	1.73869278
86	Hypoplasia of the pons (HP:0012110)	1.73723398
87	Furrowed tongue (HP:0000221)	1.73653018
88	Type II diabetes mellitus (HP:0005978)	1.72713322
89	Facial shape deformation (HP:0011334)	1.72679502
90	Potter facies (HP:0002009)	1.72679502
91	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.71450396
92	Postaxial foot polydactyly (HP:0001830)	1.69332213
93	Thyroiditis (HP:0100646)	1.69293623
94	Tetany (HP:0001281)	1.67573170
95	Acute necrotizing encephalopathy (HP:0006965)	1.66231186
96	Infertility (HP:0000789)	1.65687742
97	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.65517227
98	Hypoproteinemia (HP:0003075)	1.65189766
99	Broad-based gait (HP:0002136)	1.65026919
100	Hyperalaninemia (HP:0003348)	1.64680751

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.81985224
2	MAP4K2	3.83193165
3	PLK4	3.42681639
4	INSRR	3.35062663
5	ADRBK2	2.97784146
6	BMPR1B	2.87833367
7	WNK4	2.37564355
8	WNK3	2.33424498
9	MAPK13	2.17488887
10	ZAK	2.16080797
11	PINK1	2.15963822
12	PLK2	2.14533936
13	NUAK1	1.86178929
14	STK38L	1.85083533
15	GRK1	1.83432875
16	PNCK	1.75811714
17	CASK	1.74990248
18	PTK2B	1.69852326
19	ACVR1B	1.66902129
20	MAP3K4	1.66759588
21	TXK	1.56855223
22	OXSR1	1.54503016
23	TRIM28	1.47572114
24	MKNK2	1.46263400
25	DAPK2	1.42949470
26	TLK1	1.40137134
27	STK39	1.37549531
28	MARK1	1.23156074
29	MUSK	1.19470511
30	TAOK3	1.15467904
31	CAMK1G	1.00878104
32	PAK3	0.99803793
33	MAP2K7	0.96957874
34	FER	0.94673728
35	DDR2	0.93264914
36	ADRBK1	0.89553781
37	PRKCG	0.88164269
38	NME1	0.85433645
39	PRKCE	0.79974978
40	MAPKAPK3	0.76981790
41	EIF2AK3	0.75921391
42	MAPK15	0.71324460
43	MAP2K6	0.71106312
44	WNK1	0.69701759
45	FGFR2	0.69363159
46	TIE1	0.67621339
47	PIK3CG	0.67189911
48	PHKG1	0.66553684
49	PHKG2	0.66553684
50	MST4	0.65719340
51	STK38	0.64533465
52	STK3	0.61674855
53	CAMKK2	0.60602163
54	TNK2	0.58792220
55	BCKDK	0.58777132
56	CAMK1	0.58432797
57	PRKAA2	0.56286255
58	GRK7	0.54637992
59	TGFBR1	0.53878632
60	PRKG1	0.53293685
61	CSNK1G1	0.53292956
62	MKNK1	0.52623344
63	CAMK2A	0.52216081
64	DYRK2	0.50999430
65	TESK1	0.50481034
66	BCR	0.50447612
67	CAMK1D	0.49461949
68	WEE1	0.49273425
69	CSNK1G2	0.48080534
70	BRD4	0.47928785
71	PIK3CA	0.47758434
72	TNIK	0.47190772
73	MAPKAPK5	0.46641599
74	CSNK1G3	0.46476285
75	PRKCZ	0.46368279
76	CSNK1A1	0.46000647
77	BRSK2	0.45103387
78	PDK1	0.44356117
79	PRKACA	0.42216971
80	SRPK1	0.41246965
81	ERBB3	0.41005998
82	TEC	0.40958667
83	TYRO3	0.39701308
84	NTRK3	0.39096949
85	CDK3	0.38263850
86	PLK3	0.36552737
87	IKBKB	0.36527289
88	ROCK1	0.33835452
89	CSNK1D	0.31927217
90	RPS6KA5	0.30173830
91	PRKCA	0.29592327
92	CAMK4	0.27817000
93	PRKCQ	0.26251621
94	STK11	0.26245534
95	PRKAA1	0.25691714
96	CSNK1A1L	0.25611303
97	PRKCB	0.24590048
98	PRKCI	0.24449518
99	LATS1	0.23824028
100	VRK1	0.23248435

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.39048379
2	Caffeine metabolism_Homo sapiens_hsa00232	3.29451747
3	Butanoate metabolism_Homo sapiens_hsa00650	2.87809752
4	Phototransduction_Homo sapiens_hsa04744	2.82760586
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.41506101
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.34640312
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.31262744
8	Olfactory transduction_Homo sapiens_hsa04740	2.28511839
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.21194862
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.02351335
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.01176626
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.99941916
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.93395131
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75652108
15	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.75196552
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.72890048
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.71553408
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.67506850
19	Nicotine addiction_Homo sapiens_hsa05033	1.64771627
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.52899271
21	Taste transduction_Homo sapiens_hsa04742	1.51377048
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.46452989
23	Basal transcription factors_Homo sapiens_hsa03022	1.42792299
24	ABC transporters_Homo sapiens_hsa02010	1.41475317
25	Propanoate metabolism_Homo sapiens_hsa00640	1.39842560
26	Allograft rejection_Homo sapiens_hsa05330	1.28669592
27	Type I diabetes mellitus_Homo sapiens_hsa04940	1.27124329
28	Homologous recombination_Homo sapiens_hsa03440	1.24218574
29	Morphine addiction_Homo sapiens_hsa05032	1.20932509
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.19549288
31	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.18907887
32	Parkinsons disease_Homo sapiens_hsa05012	1.18315590
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.17829758
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.15186048
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.14512871
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.11321094
37	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.10810971
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.08942933
39	Insulin secretion_Homo sapiens_hsa04911	1.08381629
40	Protein export_Homo sapiens_hsa03060	1.07058446
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06483981
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.05322964
43	Retinol metabolism_Homo sapiens_hsa00830	1.02688895
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.00706649
45	Asthma_Homo sapiens_hsa05310	1.00462524
46	Graft-versus-host disease_Homo sapiens_hsa05332	0.99568973
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.98640709
48	Huntingtons disease_Homo sapiens_hsa05016	0.96451311
49	Salivary secretion_Homo sapiens_hsa04970	0.96233945
50	Peroxisome_Homo sapiens_hsa04146	0.93195830
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.91204172
52	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.89987122
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.88739429
54	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.87719137
55	Circadian entrainment_Homo sapiens_hsa04713	0.84573729
56	Serotonergic synapse_Homo sapiens_hsa04726	0.84518717
57	RNA degradation_Homo sapiens_hsa03018	0.84433259
58	Fatty acid degradation_Homo sapiens_hsa00071	0.84125307
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.84106396
60	RNA polymerase_Homo sapiens_hsa03020	0.83451204
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80748141
62	GABAergic synapse_Homo sapiens_hsa04727	0.80486158
63	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77955065
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.77584633
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.75769900
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.75239926
67	Regulation of autophagy_Homo sapiens_hsa04140	0.70600618
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70108792
69	Glutamatergic synapse_Homo sapiens_hsa04724	0.69332212
70	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.67521765
71	Metabolic pathways_Homo sapiens_hsa01100	0.66184494
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65511057
73	Alzheimers disease_Homo sapiens_hsa05010	0.64660801
74	One carbon pool by folate_Homo sapiens_hsa00670	0.62384818
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.61949794
76	RNA transport_Homo sapiens_hsa03013	0.61538791
77	Purine metabolism_Homo sapiens_hsa00230	0.61258389
78	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.56462649
79	Proteasome_Homo sapiens_hsa03050	0.55301962
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55073988
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.52012680
82	Mineral absorption_Homo sapiens_hsa04978	0.50788378
83	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49843364
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.49181379
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49047337
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.47388933
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.43820776
88	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.37276844
89	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.34687054
90	Circadian rhythm_Homo sapiens_hsa04710	0.33866004
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33839848
92	Antigen processing and presentation_Homo sapiens_hsa04612	0.33729902
93	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.33138686
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.32996806
95	Histidine metabolism_Homo sapiens_hsa00340	0.30836927
96	Pancreatic secretion_Homo sapiens_hsa04972	0.29715673
97	Sulfur metabolism_Homo sapiens_hsa00920	0.29246199
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.29176489
99	Oocyte meiosis_Homo sapiens_hsa04114	0.28288137
100	Type II diabetes mellitus_Homo sapiens_hsa04930	0.26432525

SPATA31A7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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