ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	9.80477949
2	chromosome condensation (GO:0030261)	8.08178747
3	microtubule depolymerization (GO:0007019)	7.95433297
4	DNA packaging (GO:0006323)	7.88850039
5	protein targeting to Golgi (GO:0000042)	7.86650202
6	response to pheromone (GO:0019236)	7.86139055
7	protein polyglutamylation (GO:0018095)	7.81399476
8	sperm capacitation (GO:0048240)	7.70628226
9	single strand break repair (GO:0000012)	7.66310959
10	establishment of protein localization to Golgi (GO:0072600)	7.63774979
11	spermatid development (GO:0007286)	7.54052365
12	plasma membrane fusion (GO:0045026)	7.47702541
13	retrograde transport, vesicle recycling within Golgi (GO:0000301)	7.29492409
14	rRNA methylation (GO:0031167)	7.25053215
15	microtubule polymerization or depolymerization (GO:0031109)	7.08947649
16	sperm-egg recognition (GO:0035036)	6.91295784
17	spermatid nucleus differentiation (GO:0007289)	6.88238658
18	centriole replication (GO:0007099)	6.82745574
19	multicellular organism reproduction (GO:0032504)	6.81887199
20	rRNA modification (GO:0000154)	6.25543918
21	calcium ion-dependent exocytosis (GO:0017156)	6.23365898
22	reproduction (GO:0000003)	6.11392074
23	axonemal dynein complex assembly (GO:0070286)	5.97759616
24	* spermatogenesis (GO:0007283)	5.96165258
25	binding of sperm to zona pellucida (GO:0007339)	5.96165124
26	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.94932635
27	* male gamete generation (GO:0048232)	5.94852831
28	protein localization to Golgi apparatus (GO:0034067)	5.85896491
29	regulation of centriole replication (GO:0046599)	5.71063264
30	centriole assembly (GO:0098534)	5.69213125
31	cell-cell recognition (GO:0009988)	5.68304160
32	phosphatidylethanolamine metabolic process (GO:0046337)	5.55391286
33	* gamete generation (GO:0007276)	5.47113080
34	regulation of cilium movement (GO:0003352)	5.46437628
35	seminiferous tubule development (GO:0072520)	5.46287275
36	microtubule severing (GO:0051013)	5.23190130
37	cellular ketone body metabolic process (GO:0046950)	5.10715392
38	sexual reproduction (GO:0019953)	5.07075499
39	cilium or flagellum-dependent cell motility (GO:0001539)	4.96093336
40	single fertilization (GO:0007338)	4.95808504
41	negative regulation of inclusion body assembly (GO:0090084)	4.90952094
42	epithelial cilium movement (GO:0003351)	4.88670474
43	RNA destabilization (GO:0050779)	4.78716754
44	cell wall macromolecule catabolic process (GO:0016998)	4.77978202
45	motile cilium assembly (GO:0044458)	4.76074382
46	cell wall macromolecule metabolic process (GO:0044036)	4.51406740
47	regulation of Rab GTPase activity (GO:0032313)	4.51000863
48	positive regulation of Rab GTPase activity (GO:0032851)	4.51000863
49	ketone body metabolic process (GO:1902224)	4.49700708
50	fertilization (GO:0009566)	4.32541661
51	* multicellular organismal reproductive process (GO:0048609)	4.32238454
52	germ cell development (GO:0007281)	4.28817684
53	microtubule nucleation (GO:0007020)	4.23907060
54	glomerular visceral epithelial cell development (GO:0072015)	4.22980724
55	cilium movement (GO:0003341)	4.18091630
56	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.00452251
57	glomerular epithelial cell development (GO:0072310)	3.93775573
58	musculoskeletal movement (GO:0050881)	3.87771410
59	multicellular organismal movement (GO:0050879)	3.87771410
60	chromatin silencing (GO:0006342)	3.84467346
61	regulation of inclusion body assembly (GO:0090083)	3.69775766
62	regulation of transcription involved in cell fate commitment (GO:0060850)	3.69599274
63	nucleus organization (GO:0006997)	3.67607567
64	regulation of microtubule-based movement (GO:0060632)	3.66823291
65	organic cation transport (GO:0015695)	3.53098246
66	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.49603783
67	glycerol ether metabolic process (GO:0006662)	3.48908610
68	piRNA metabolic process (GO:0034587)	3.47288355
69	axoneme assembly (GO:0035082)	3.41064810
70	coenzyme catabolic process (GO:0009109)	3.35884082
71	ether metabolic process (GO:0018904)	3.24802783
72	negative regulation of Rho protein signal transduction (GO:0035024)	3.23996218
73	positive regulation of guanylate cyclase activity (GO:0031284)	3.17205641
74	intra-Golgi vesicle-mediated transport (GO:0006891)	3.15007898
75	male meiosis I (GO:0007141)	3.11744328
76	DNA methylation involved in gamete generation (GO:0043046)	3.08987518
77	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.99421546
78	regulation of guanylate cyclase activity (GO:0031282)	2.91687485
79	cell recognition (GO:0008037)	2.89618884
80	regulation of meiosis I (GO:0060631)	2.88741048
81	multicellular organismal development (GO:0007275)	2.86901644
82	male meiosis (GO:0007140)	2.86707031
83	ventricular system development (GO:0021591)	2.79311876
84	Golgi to endosome transport (GO:0006895)	2.78509125
85	histone mRNA catabolic process (GO:0071044)	2.77968216
86	nuclear pore complex assembly (GO:0051292)	2.76664728
87	cilium organization (GO:0044782)	2.75358896
88	cellular response to pH (GO:0071467)	2.75128497
89	cilium assembly (GO:0042384)	2.73266139
90	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.72827896
91	membrane protein intracellular domain proteolysis (GO:0031293)	2.70942109
92	spinal cord motor neuron differentiation (GO:0021522)	2.69942262
93	cerebral cortex neuron differentiation (GO:0021895)	2.67451542
94	RNA methylation (GO:0001510)	2.66405222
95	peptidyl-glutamic acid modification (GO:0018200)	2.65126710
96	polyamine biosynthetic process (GO:0006596)	2.64418682
97	response to acidic pH (GO:0010447)	2.63732718
98	protein depolymerization (GO:0051261)	2.61141547
99	sperm motility (GO:0030317)	11.3938250
100	acrosome reaction (GO:0007340)	10.9543405

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.88758558
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.68385084
3	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.58825320
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.58825320
5	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.54732218
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.53032644
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.51572519
8	FUS_26573619_Chip-Seq_HEK293_Human	2.51322987
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.45918651
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.41269849
11	CBP_20019798_ChIP-Seq_JUKART_Human	2.39905385
12	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.39905385
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.38602158
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.29114196
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.07393587
16	VDR_22108803_ChIP-Seq_LS180_Human	1.96729071
17	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.95488380
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.93589361
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.93464857
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.82194268
21	P300_19829295_ChIP-Seq_ESCs_Human	1.77993920
22	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.73698032
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.73698001
24	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.72031491
25	ERA_21632823_ChIP-Seq_H3396_Human	1.71845031
26	AR_25329375_ChIP-Seq_VCAP_Human	1.65728576
27	DROSHA_22980978_ChIP-Seq_HELA_Human	1.65388415
28	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.65076787
29	RAC3_21632823_ChIP-Seq_H3396_Human	1.64118516
30	MYC_19829295_ChIP-Seq_ESCs_Human	1.63491160
31	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.61802704
32	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.60216131
33	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.56627545
34	NANOG_20526341_ChIP-Seq_ESCs_Human	1.56447628
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.52926315
36	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.52563617
37	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.49161949
38	TAF2_19829295_ChIP-Seq_ESCs_Human	1.47265463
39	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.46834668
40	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.45260682
41	ETV1_20927104_ChIP-Seq_GIST48_Human	1.43968321
42	RBPJ_21746931_ChIP-Seq_IB4_Human	1.43768647
43	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.43062340
44	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.42654630
45	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.41843599
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40778454
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.40688141
48	STAT3_23295773_ChIP-Seq_U87_Human	1.39668457
49	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.39622567
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39573584
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.39178420
52	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.35076868
53	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.34831172
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.33788771
55	NFYB_21822215_ChIP-Seq_K562_Human	1.33307168
56	OCT4_20526341_ChIP-Seq_ESCs_Human	1.31787232
57	TBL1_22424771_ChIP-Seq_293T_Human	1.31707515
58	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.31288407
59	ERG_20517297_ChIP-Seq_VCAP_Human	1.29708604
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29322618
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29322618
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29207631
63	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.29122067
64	PHF8_20622853_ChIP-Seq_HELA_Human	1.27872513
65	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.26597695
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.25513585
67	TP53_18474530_ChIP-ChIP_U2OS_Human	1.25179417
68	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23099575
69	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.22043286
70	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.21433988
71	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.20174103
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18764202
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18764202
74	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.18336577
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16847281
76	CEBPB_22108803_ChIP-Seq_LS180_Human	1.16800774
77	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.16123081
78	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.14826918
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13591276
80	CTCF_27219007_Chip-Seq_Bcells_Human	1.12845059
81	NFYA_21822215_ChIP-Seq_K562_Human	1.12545110
82	TCF4_23295773_ChIP-Seq_U87_Human	1.12306145
83	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.12072354
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11318065
85	AR_21572438_ChIP-Seq_LNCaP_Human	1.11205104
86	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.09511416
87	P53_21459846_ChIP-Seq_SAOS-2_Human	1.09351463
88	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08884070
89	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.08206555
90	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.07712408
91	NCOR_22424771_ChIP-Seq_293T_Human	1.07575641
92	CTCF_20526341_ChIP-Seq_ESCs_Human	1.07417887
93	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06452785
94	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05695460
95	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.04421436
96	E2F1_20622854_ChIP-Seq_HELA_Human	1.04326928
97	KDM2B_26808549_Chip-Seq_REH_Human	1.04192617
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04017820
99	PHF8_20622854_ChIP-Seq_HELA_Human	1.03154389
100	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.03040069

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	5.20508370
2	MP0005377_hearing/vestibular/ear_phenot	5.20508370
3	MP0003698_abnormal_male_reproductive	4.02754695
4	MP0005670_abnormal_white_adipose	3.70381639
5	MP0001929_abnormal_gametogenesis	3.54658837
6	MP0001348_abnormal_lacrimal_gland	2.78519522
7	MP0003646_muscle_fatigue	2.58816588
8	MP0003718_maternal_effect	2.31590427
9	MP0001485_abnormal_pinna_reflex	2.22039830
10	MP0002161_abnormal_fertility/fecundity	2.16910438
11	MP0003011_delayed_dark_adaptation	2.06534369
12	MP0008877_abnormal_DNA_methylation	2.06176060
13	MP0005410_abnormal_fertilization	10.4642343
14	MP0005379_endocrine/exocrine_gland_phen	1.97374700
15	MP0001486_abnormal_startle_reflex	1.95219402
16	MP0004742_abnormal_vestibular_system	1.95182001
17	MP0005551_abnormal_eye_electrophysiolog	1.77991514
18	MP0002210_abnormal_sex_determination	1.77626808
19	MP0001968_abnormal_touch/_nociception	1.73145577
20	MP0005423_abnormal_somatic_nervous	1.52432693
21	MP0001145_abnormal_male_reproductive	1.42139285
22	MP0002282_abnormal_trachea_morphology	1.40392064
23	MP0002234_abnormal_pharynx_morphology	1.38262928
24	MP0005253_abnormal_eye_physiology	1.37803742
25	MP0005310_abnormal_salivary_gland	1.37377752
26	MP0002735_abnormal_chemical_nociception	1.37308077
27	MP0000653_abnormal_sex_gland	1.37276458
28	MP0000678_abnormal_parathyroid_gland	1.33906132
29	MP0001963_abnormal_hearing_physiology	1.32954546
30	MP0002138_abnormal_hepatobiliary_system	1.28525671
31	MP0001984_abnormal_olfaction	1.19415833
32	MP0004859_abnormal_synaptic_plasticity	1.18138914
33	MP0002132_abnormal_respiratory_system	1.16486179
34	MP0000026_abnormal_inner_ear	1.15791154
35	MP0003879_abnormal_hair_cell	1.15682250
36	MP0001765_abnormal_ion_homeostasis	1.12698659
37	MP0001501_abnormal_sleep_pattern	1.09028019
38	MP0002067_abnormal_sensory_capabilities	1.05528562
39	MP0002557_abnormal_social/conspecific_i	1.04326556
40	MP0006292_abnormal_olfactory_placode	1.04287914
41	MP0002229_neurodegeneration	1.04229570
42	MP0002733_abnormal_thermal_nociception	1.00619366
43	MP0009697_abnormal_copulation	0.99608087
44	MP0002272_abnormal_nervous_system	0.99436591
45	MP0005395_other_phenotype	0.98330449
46	MP0002572_abnormal_emotion/affect_behav	0.98012005
47	MP0009745_abnormal_behavioral_response	0.97212695
48	MP0005167_abnormal_blood-brain_barrier	0.96995368
49	MP0003880_abnormal_central_pattern	0.93458907
50	MP0005645_abnormal_hypothalamus_physiol	0.92311715
51	MP0002736_abnormal_nociception_after	0.89190666
52	MP0000955_abnormal_spinal_cord	0.86892457
53	MP0002822_catalepsy	0.85466325
54	MP0001970_abnormal_pain_threshold	0.80505456
55	MP0005636_abnormal_mineral_homeostasis	0.79124997
56	MP0004085_abnormal_heartbeat	0.78274784
57	MP0000569_abnormal_digit_pigmentation	0.78153957
58	MP0000230_abnormal_systemic_arterial	0.75671062
59	MP0001905_abnormal_dopamine_level	0.75317703
60	MP0006276_abnormal_autonomic_nervous	0.73699794
61	MP0005248_abnormal_Harderian_gland	0.73344601
62	MP0002249_abnormal_larynx_morphology	0.72685557
63	MP0002254_reproductive_system_inflammat	0.72603127
64	MP0003137_abnormal_impulse_conducting	0.72199631
65	MP0008789_abnormal_olfactory_epithelium	0.72067199
66	MP0002734_abnormal_mechanical_nocicepti	0.72053348
67	MP0008995_early_reproductive_senescence	0.71686829
68	MP0005084_abnormal_gallbladder_morpholo	0.71645759
69	MP0008872_abnormal_physiological_respon	0.71523309
70	MP0009053_abnormal_anal_canal	0.70015136
71	MP0009046_muscle_twitch	0.69493089
72	MP0000049_abnormal_middle_ear	0.68573260
73	MP0009115_abnormal_fat_cell	0.68487460
74	MP0002127_abnormal_cardiovascular_syste	0.66795851
75	MP0000534_abnormal_ureter_morphology	0.66255145
76	MP0002102_abnormal_ear_morphology	0.66210908
77	MP0005451_abnormal_body_composition	0.66171245
78	MP0002653_abnormal_ependyma_morphology	0.65519984
79	MP0003635_abnormal_synaptic_transmissio	0.63248288
80	MP0002928_abnormal_bile_duct	0.62444783
81	MP0005391_vision/eye_phenotype	0.60982147
82	MP0008569_lethality_at_weaning	0.59158440
83	MP0001440_abnormal_grooming_behavior	0.59081264
84	MP0008775_abnormal_heart_ventricle	0.57711477
85	MP0000516_abnormal_urinary_system	0.57534804
86	MP0005367_renal/urinary_system_phenotyp	0.57534804
87	MP0003787_abnormal_imprinting	0.56625554
88	MP0010329_abnormal_lipoprotein_level	0.55661573
89	MP0002837_dystrophic_cardiac_calcinosis	0.55421055
90	MP0004084_abnormal_cardiac_muscle	0.51999308
91	MP0005332_abnormal_amino_acid	0.51891989
92	MP0002752_abnormal_somatic_nervous	0.51823300
93	MP0009764_decreased_sensitivity_to	0.51625626
94	MP0002184_abnormal_innervation	0.50104021
95	MP0006072_abnormal_retinal_apoptosis	0.48903428
96	MP0005535_abnormal_body_temperature	0.48195940
97	MP0002882_abnormal_neuron_morphology	0.47968760
98	MP0002063_abnormal_learning/memory/cond	0.47044069
99	MP0004885_abnormal_endolymph	0.46286386
100	MP0001529_abnormal_vocalization	0.45648785

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	6.75760471
2	Chronic hepatic failure (HP:0100626)	6.01126395
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.91663768
4	Absent/shortened dynein arms (HP:0200106)	5.91663768
5	Tubulointerstitial nephritis (HP:0001970)	5.78940816
6	Attenuation of retinal blood vessels (HP:0007843)	4.92550392
7	Bony spicule pigmentary retinopathy (HP:0007737)	4.44956565
8	Abnormal ciliary motility (HP:0012262)	4.37346223
9	Asymmetric septal hypertrophy (HP:0001670)	4.25937286
10	Abnormal respiratory motile cilium physiology (HP:0012261)	4.23366728
11	Abnormal respiratory epithelium morphology (HP:0012253)	4.14204333
12	Abnormal respiratory motile cilium morphology (HP:0005938)	4.14204333
13	Abnormality of macular pigmentation (HP:0008002)	4.01704948
14	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.94419750
15	Cone-rod dystrophy (HP:0000548)	3.85534187
16	Nephronophthisis (HP:0000090)	3.83167845
17	Abnormal rod and cone electroretinograms (HP:0008323)	3.71793403
18	Hyperkalemia (HP:0002153)	3.67011126
19	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.41049204
20	Nasal polyposis (HP:0100582)	3.38614359
21	Infertility (HP:0000789)	3.35682578
22	Abnormality of the renal medulla (HP:0100957)	3.34371078
23	Resting tremor (HP:0002322)	3.29904289
24	Male infertility (HP:0003251)	3.27552069
25	Impulsivity (HP:0100710)	3.15244575
26	Amelogenesis imperfecta (HP:0000705)	3.13788491
27	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.13532843
28	Progressive cerebellar ataxia (HP:0002073)	3.12586472
29	Potter facies (HP:0002009)	3.09224694
30	Facial shape deformation (HP:0011334)	3.09224694
31	Tubulointerstitial abnormality (HP:0001969)	3.01606065
32	Menstrual irregularities (HP:0000858)	3.00000662
33	Abnormality of dental color (HP:0011073)	2.94799691
34	Stage 5 chronic kidney disease (HP:0003774)	2.93113407
35	Hypoplasia of the thymus (HP:0000778)	2.92885022
36	Polydipsia (HP:0001959)	2.90186688
37	Abnormal drinking behavior (HP:0030082)	2.90186688
38	Progressive sensorineural hearing impairment (HP:0000408)	2.86999779
39	Hypoplastic ischia (HP:0003175)	2.84896854
40	Abnormal spermatogenesis (HP:0008669)	2.79857734
41	Abnormal urine output (HP:0012590)	2.76707960
42	Pancreatic cysts (HP:0001737)	2.76136008
43	Bell-shaped thorax (HP:0001591)	2.72807518
44	Truncal obesity (HP:0001956)	2.72605252
45	Pancreatic fibrosis (HP:0100732)	2.71779904
46	Hypoalphalipoproteinemia (HP:0003233)	2.71443297
47	Enlarged epiphyses (HP:0010580)	2.63750433
48	Azoospermia (HP:0000027)	2.61771876
49	Abnormality of the nasal mucosa (HP:0000433)	2.61707578
50	Insulin-resistant diabetes mellitus (HP:0000831)	2.57566219
51	Tubular atrophy (HP:0000092)	2.54608529
52	Polyuria (HP:0000103)	2.54090262
53	Rhinitis (HP:0012384)	2.53501950
54	Portal hypertension (HP:0001409)	2.51950207
55	Abnormality of the ischium (HP:0003174)	2.47471364
56	Renovascular hypertension (HP:0100817)	2.45077436
57	Postural instability (HP:0002172)	2.44797458
58	Optic nerve hypoplasia (HP:0000609)	2.41572929
59	Abnormality of renal excretion (HP:0011036)	2.39208075
60	Pendular nystagmus (HP:0012043)	2.32534832
61	True hermaphroditism (HP:0010459)	2.30153140
62	Abnormality of the hepatic vasculature (HP:0006707)	2.29376443
63	Abnormality of potassium homeostasis (HP:0011042)	2.28761008
64	Abnormality of the aortic arch (HP:0012303)	2.28284506
65	Abnormality of midbrain morphology (HP:0002418)	2.27278996
66	Molar tooth sign on MRI (HP:0002419)	2.27278996
67	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.25547835
68	Generalized aminoaciduria (HP:0002909)	2.24874853
69	Chronic bronchitis (HP:0004469)	2.22839212
70	Intellectual disability, moderate (HP:0002342)	2.22251705
71	Type II lissencephaly (HP:0007260)	2.20367740
72	Decreased central vision (HP:0007663)	2.17495409
73	Congenital sensorineural hearing impairment (HP:0008527)	2.11170146
74	Abnormality of the renal cortex (HP:0011035)	2.07078195
75	Hypoalbuminemia (HP:0003073)	2.06317293
76	Abnormal albumin level (HP:0012116)	2.06317293
77	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.04688209
78	Myokymia (HP:0002411)	2.00159412
79	Renal Fanconi syndrome (HP:0001994)	1.97503305
80	Congenital stationary night blindness (HP:0007642)	1.96712898
81	Cystic liver disease (HP:0006706)	1.94017332
82	Photophobia (HP:0000613)	1.93877626
83	Bronchiectasis (HP:0002110)	1.92671873
84	Cerebellar dysplasia (HP:0007033)	1.91937309
85	Occipital encephalocele (HP:0002085)	1.89639879
86	Focal segmental glomerulosclerosis (HP:0000097)	1.89343177
87	Abnormality of the costochondral junction (HP:0000919)	1.86054864
88	Increased purine levels (HP:0004368)	1.85783981
89	Hyperuricemia (HP:0002149)	1.85783981
90	Congenital malformation of the right heart (HP:0011723)	1.85481321
91	Double outlet right ventricle (HP:0001719)	1.85481321
92	Renal dysplasia (HP:0000110)	1.83709645
93	Glycosuria (HP:0003076)	1.80416894
94	Abnormality of urine glucose concentration (HP:0011016)	1.80416894
95	Progressive hearing impairment (HP:0001730)	1.78399963
96	Hypophosphatemic rickets (HP:0004912)	1.76011801
97	Growth hormone deficiency (HP:0000824)	1.75586165
98	Sclerocornea (HP:0000647)	1.74577524
99	Congenital hepatic fibrosis (HP:0002612)	1.74375398
100	Type II diabetes mellitus (HP:0005978)	1.73618668

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.86111882
2	INSRR	4.67197913
3	MAP4K2	4.05160064
4	TESK1	3.70753776
5	PLK2	3.69471781
6	BRD4	3.56870717
7	PNCK	3.45270033
8	DDR2	2.79198715
9	STK38L	2.43551583
10	STK38	2.33735561
11	CAMK1G	2.33251041
12	PIK3CG	2.17460000
13	FRK	1.80783763
14	MAPK15	1.58657639
15	PRKD3	1.52947452
16	WNK1	1.44165227
17	PTK2B	1.37996979
18	BMPR1B	1.32465082
19	ADRBK2	1.23608275
20	NUAK1	1.19354522
21	TYRO3	1.16425569
22	PDK1	1.14382139
23	WNK4	1.12081197
24	NEK6	1.09396247
25	AKT3	1.05253145
26	PDPK1	1.00090090
27	MARK1	0.94493083
28	STK39	0.91534205
29	CAMK1D	0.90787682
30	BRSK2	0.88149401
31	WNK3	0.86458470
32	DYRK1B	0.81659135
33	TNIK	0.81563139
34	TIE1	0.81535091
35	OXSR1	0.80906122
36	CDK7	0.76618732
37	MST1R	0.76567378
38	ZAK	0.72138453
39	SIK2	0.71789646
40	CASK	0.67558681
41	CAMK1	0.67313040
42	PRKG1	0.66550882
43	MAP3K4	0.66410976
44	CDK3	0.62641727
45	ACVR1B	0.61690445
46	PRKCG	0.61037889
47	PINK1	0.60684124
48	PRKG2	0.59705745
49	GRK1	0.57931226
50	PRKAA2	0.55733538
51	MAPK13	0.55669817
52	DYRK2	0.54782495
53	LATS1	0.54464880
54	NTRK3	0.47739289
55	BRSK1	0.46463363
56	CAMK4	0.44308797
57	VRK1	0.43413520
58	UHMK1	0.42023860
59	ROCK1	0.41097404
60	MKNK2	0.40326368
61	BRAF	0.39715244
62	MAP3K11	0.39162083
63	TRIM28	0.37345317
64	GSK3B	0.37128105
65	PRKCE	0.36774739
66	MAP3K9	0.36590017
67	CDK1	0.35618199
68	RPS6KA1	0.35114757
69	DAPK2	0.33987336
70	PRKCZ	0.33613907
71	CDK2	0.32214079
72	CDK12	0.32206372
73	SGK223	0.32092464
74	SGK494	0.32092464
75	PKN1	0.31558593
76	MAPK1	0.30936866
77	MAPK8	0.29088083
78	FER	0.28998842
79	CAMK2A	0.28442697
80	MAP2K2	0.26694194
81	TLK1	0.24885365
82	PRKCB	0.23844961
83	RPS6KA2	0.23227786
84	PRKACA	0.22335484
85	FGFR2	0.22211676
86	SGK1	0.21428004
87	MUSK	0.21324995
88	TAOK3	0.21003516
89	CHEK1	0.19909591
90	PLK1	0.19575004
91	PAK3	0.19295691
92	MAPK14	0.18579263
93	CDK19	0.18228662
94	MAP2K7	0.18022267
95	CSNK1A1	0.17407391
96	PRKACB	0.16895474
97	RPS6KA6	0.14736359
98	CSNK1D	0.13588271
99	PRKAA1	0.13577061
100	DYRK3	0.13552590

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	6.90311784
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.51820692
3	Olfactory transduction_Homo sapiens_hsa04740	3.74808898
4	Butanoate metabolism_Homo sapiens_hsa00650	2.97862219
5	Phototransduction_Homo sapiens_hsa04744	2.43306725
6	Taste transduction_Homo sapiens_hsa04742	2.04453360
7	RNA transport_Homo sapiens_hsa03013	2.01193868
8	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.93933653
9	Nitrogen metabolism_Homo sapiens_hsa00910	1.88893855
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.70521967
11	Nicotine addiction_Homo sapiens_hsa05033	1.65602879
12	Fatty acid degradation_Homo sapiens_hsa00071	1.52483744
13	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.49437431
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.46246147
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.33572997
16	Fatty acid metabolism_Homo sapiens_hsa01212	1.33139515
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32663561
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.28954517
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24552010
20	Morphine addiction_Homo sapiens_hsa05032	1.23948972
21	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.20369242
22	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.19775420
23	Allograft rejection_Homo sapiens_hsa05330	1.18792569
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.17818357
25	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.16221207
26	Type II diabetes mellitus_Homo sapiens_hsa04930	1.15612030
27	Salivary secretion_Homo sapiens_hsa04970	1.13804382
28	ABC transporters_Homo sapiens_hsa02010	1.13152233
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.11708174
30	Antigen processing and presentation_Homo sapiens_hsa04612	1.09340514
31	Glutamatergic synapse_Homo sapiens_hsa04724	1.06604436
32	Basal transcription factors_Homo sapiens_hsa03022	1.05405860
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04525205
34	Graft-versus-host disease_Homo sapiens_hsa05332	1.03346719
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.00853632
36	Fat digestion and absorption_Homo sapiens_hsa04975	0.99359938
37	Glycerolipid metabolism_Homo sapiens_hsa00561	0.99050290
38	Calcium signaling pathway_Homo sapiens_hsa04020	0.98170735
39	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.98047948
40	Circadian entrainment_Homo sapiens_hsa04713	0.97967285
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.97823107
42	Arginine and proline metabolism_Homo sapiens_hsa00330	0.94199787
43	Retinol metabolism_Homo sapiens_hsa00830	0.93359231
44	Phenylalanine metabolism_Homo sapiens_hsa00360	0.90310276
45	Serotonergic synapse_Homo sapiens_hsa04726	0.89727052
46	Insulin secretion_Homo sapiens_hsa04911	0.88951472
47	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.86210053
48	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.85804478
49	Propanoate metabolism_Homo sapiens_hsa00640	0.81481685
50	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.80037504
51	cAMP signaling pathway_Homo sapiens_hsa04024	0.79993321
52	Huntingtons disease_Homo sapiens_hsa05016	0.78619831
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.78016265
54	GABAergic synapse_Homo sapiens_hsa04727	0.74501615
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.74184175
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.70358595
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.70281670
58	Protein digestion and absorption_Homo sapiens_hsa04974	0.69991357
59	Purine metabolism_Homo sapiens_hsa00230	0.65436346
60	Arginine biosynthesis_Homo sapiens_hsa00220	0.65373701
61	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.62827875
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61357752
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60762362
64	Oocyte meiosis_Homo sapiens_hsa04114	0.60385390
65	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.57152315
66	PPAR signaling pathway_Homo sapiens_hsa03320	0.53922788
67	Homologous recombination_Homo sapiens_hsa03440	0.53841496
68	Tyrosine metabolism_Homo sapiens_hsa00350	0.53694674
69	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.53101277
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.52470531
71	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.52256292
72	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.51892995
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50135541
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.48545991
75	Pancreatic secretion_Homo sapiens_hsa04972	0.48536618
76	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.47318127
77	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.46420736
78	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.45873362
79	Renin secretion_Homo sapiens_hsa04924	0.44839438
80	One carbon pool by folate_Homo sapiens_hsa00670	0.44714055
81	Regulation of autophagy_Homo sapiens_hsa04140	0.44455379
82	Metabolic pathways_Homo sapiens_hsa01100	0.44057359
83	Peroxisome_Homo sapiens_hsa04146	0.43199891
84	Gastric acid secretion_Homo sapiens_hsa04971	0.43126180
85	Amphetamine addiction_Homo sapiens_hsa05031	0.43056103
86	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.41516173
87	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.41060990
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.40011908
89	Viral myocarditis_Homo sapiens_hsa05416	0.39930080
90	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.37296449
91	Bile secretion_Homo sapiens_hsa04976	0.36060611
92	mRNA surveillance pathway_Homo sapiens_hsa03015	0.35241937
93	Cholinergic synapse_Homo sapiens_hsa04725	0.33214352
94	Sulfur relay system_Homo sapiens_hsa04122	0.33084166
95	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.30758008
96	Caffeine metabolism_Homo sapiens_hsa00232	0.30625607
97	Endocytosis_Homo sapiens_hsa04144	0.29257998
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.28895578
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.28467847
100	RNA degradation_Homo sapiens_hsa03018	0.28212067

SPATA31C1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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