SPATA31D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.48859207
2response to pheromone (GO:0019236)9.33612056
3DNA packaging (GO:0006323)9.06511047
4plasma membrane fusion (GO:0045026)9.03874922
5sperm capacitation (GO:0048240)8.95381300
6microtubule depolymerization (GO:0007019)8.66067487
7spermatid development (GO:0007286)8.02467024
8single strand break repair (GO:0000012)7.89363861
9sperm-egg recognition (GO:0035036)7.67349107
10spermatid nucleus differentiation (GO:0007289)7.65518727
11binding of sperm to zona pellucida (GO:0007339)7.22279317
12microtubule polymerization or depolymerization (GO:0031109)7.19823745
13multicellular organism reproduction (GO:0032504)6.97317124
14protein targeting to Golgi (GO:0000042)6.76320312
15rRNA methylation (GO:0031167)6.76028055
16calcium ion-dependent exocytosis (GO:0017156)6.72475369
17negative regulation of inclusion body assembly (GO:0090084)6.72436518
18reproduction (GO:0000003)6.58122014
19protein polyglutamylation (GO:0018095)6.57654121
20establishment of protein localization to Golgi (GO:0072600)6.51621233
21sexual reproduction (GO:0019953)6.42131390
22cell-cell recognition (GO:0009988)6.31481483
23retrograde transport, vesicle recycling within Golgi (GO:0000301)6.28294196
24* spermatogenesis (GO:0007283)6.12377374
25* male gamete generation (GO:0048232)6.10345498
26axonemal dynein complex assembly (GO:0070286)6.03386638
27phosphatidylethanolamine biosynthetic process (GO:0006646)5.92238208
28centriole replication (GO:0007099)5.83636829
29rRNA modification (GO:0000154)5.65814527
30* gamete generation (GO:0007276)5.59570241
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.45435076
32phosphatidylethanolamine metabolic process (GO:0046337)5.45229720
33microtubule severing (GO:0051013)5.42190013
34positive regulation of Rab GTPase activity (GO:0032851)5.33687697
35regulation of Rab GTPase activity (GO:0032313)5.33687697
36cellular ketone body metabolic process (GO:0046950)5.32915857
37centriole assembly (GO:0098534)5.15759706
38single fertilization (GO:0007338)4.96477725
39motile cilium assembly (GO:0044458)4.91005718
40regulation of cilium movement (GO:0003352)4.90584990
41protein localization to Golgi apparatus (GO:0034067)4.86624135
42regulation of centriole replication (GO:0046599)4.78070967
43regulation of inclusion body assembly (GO:0090083)4.72755393
44ketone body metabolic process (GO:1902224)4.69548069
45germ cell development (GO:0007281)4.64599607
46cilium or flagellum-dependent cell motility (GO:0001539)4.62966396
47regulation of transcription involved in cell fate commitment (GO:0060850)4.58096875
48chromatin silencing (GO:0006342)4.52676376
49seminiferous tubule development (GO:0072520)4.47289335
50* multicellular organismal reproductive process (GO:0048609)4.46865886
51cellular process involved in reproduction in multicellular organism (GO:0022412)4.43948100
52RNA destabilization (GO:0050779)4.40075995
53fertilization (GO:0009566)4.28226956
54cell wall macromolecule catabolic process (GO:0016998)4.24057434
55cell wall macromolecule metabolic process (GO:0044036)4.12227834
56coenzyme catabolic process (GO:0009109)4.11156491
57nucleus organization (GO:0006997)4.08622459
58glycerol ether metabolic process (GO:0006662)3.91544541
59epithelial cilium movement (GO:0003351)3.88856601
60negative regulation of Rho protein signal transduction (GO:0035024)3.82116937
61histone H3-K9 demethylation (GO:0033169)3.73838299
62musculoskeletal movement (GO:0050881)3.70835951
63multicellular organismal movement (GO:0050879)3.70835951
64glomerular visceral epithelial cell development (GO:0072015)3.65133328
65ether metabolic process (GO:0018904)3.60811855
66glomerular epithelial cell development (GO:0072310)3.49228041
67male meiosis I (GO:0007141)3.44725116
68cilium movement (GO:0003341)3.44501072
69organic cation transport (GO:0015695)3.43853029
70cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.39483233
71protein depolymerization (GO:0051261)3.31811589
72response to acidic pH (GO:0010447)3.30774371
73microtubule nucleation (GO:0007020)3.30371326
74peptidyl-threonine dephosphorylation (GO:0035970)3.27371335
75regulation of microtubule-based movement (GO:0060632)3.26873390
76cerebral cortex neuron differentiation (GO:0021895)3.26835235
77male meiosis (GO:0007140)3.20669987
78mesenchymal cell differentiation involved in renal system development (GO:2001012)3.17791642
79mesenchymal cell differentiation involved in kidney development (GO:0072161)3.17791642
80cellular response to pH (GO:0071467)3.17293901
81protein-DNA complex disassembly (GO:0032986)3.13647156
82nucleosome disassembly (GO:0006337)3.13647156
83membrane protein intracellular domain proteolysis (GO:0031293)3.12121354
84piRNA metabolic process (GO:0034587)3.11429389
85regulation of interleukin-13 production (GO:0032656)3.08641689
86polyamine biosynthetic process (GO:0006596)3.08277665
87negative regulation of gene expression, epigenetic (GO:0045814)3.07331050
88DNA methylation involved in gamete generation (GO:0043046)3.05334605
89cell recognition (GO:0008037)3.01900269
90regulation of T-helper 2 cell differentiation (GO:0045628)3.00962818
91cell differentiation involved in metanephros development (GO:0072202)2.98655347
92multicellular organismal development (GO:0007275)2.96766581
93homeostasis of number of cells within a tissue (GO:0048873)2.95689363
94DNA conformation change (GO:0071103)2.94387111
95NAD biosynthetic process (GO:0009435)2.88238068
96cranial nerve morphogenesis (GO:0021602)2.85289009
97Golgi to endosome transport (GO:0006895)2.83611195
98acrosome reaction (GO:0007340)12.2470774
99fusion of sperm to egg plasma membrane (GO:0007342)11.8995112
100sperm motility (GO:0030317)11.5228864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.72373843
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.94562281
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.76431213
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50006975
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.50006975
6CBP_20019798_ChIP-Seq_JUKART_Human2.21623057
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.21623057
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20454552
9VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.10273449
10ELF1_20517297_ChIP-Seq_JURKAT_Human2.07830564
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04686755
12ERA_21632823_ChIP-Seq_H3396_Human2.02234915
13FUS_26573619_Chip-Seq_HEK293_Human2.01084298
14RAC3_21632823_ChIP-Seq_H3396_Human1.92712757
15EZH2_22144423_ChIP-Seq_EOC_Human1.86121345
16EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.84172060
17NANOG_20526341_ChIP-Seq_ESCs_Human1.79487065
18RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.79340660
19DROSHA_22980978_ChIP-Seq_HELA_Human1.78938718
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.78620792
21WDR5_24793694_ChIP-Seq_LNCAP_Human1.77492710
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.75750955
23CTCF_27219007_Chip-Seq_Bcells_Human1.70728817
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70267629
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69513056
26MYC_19829295_ChIP-Seq_ESCs_Human1.69063022
27BCL6_27268052_Chip-Seq_Bcells_Human1.64015302
28ER_23166858_ChIP-Seq_MCF-7_Human1.63813109
29E2F1_20622854_ChIP-Seq_HELA_Human1.61684736
30SMC4_20622854_ChIP-Seq_HELA_Human1.61382532
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61158212
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.59340768
33TAF2_19829295_ChIP-Seq_ESCs_Human1.59188374
34SMAD4_21741376_ChIP-Seq_EPCs_Human1.57279584
35TDRD3_21172665_ChIP-Seq_MCF-7_Human1.57040984
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.55936509
37AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52672701
38P68_20966046_ChIP-Seq_HELA_Human1.49352635
39BCOR_27268052_Chip-Seq_Bcells_Human1.49122342
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.48845136
41PHF8_20622854_ChIP-Seq_HELA_Human1.48077526
42OCT4_20526341_ChIP-Seq_ESCs_Human1.47361065
43CTCF_20526341_ChIP-Seq_ESCs_Human1.47121657
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45665346
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44901413
46TP63_22573176_ChIP-Seq_HFKS_Human1.43695471
47TP53_18474530_ChIP-ChIP_U2OS_Human1.41882201
48HNFA_21074721_ChIP-Seq_CACO-2_Human1.40752839
49AR_25329375_ChIP-Seq_VCAP_Human1.40324867
50CBX2_22325352_ChIP-Seq_293T-Rex_Human1.39859692
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36922348
52RBPJ_21746931_ChIP-Seq_IB4_Human1.34371368
53CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.34147423
54P300_27268052_Chip-Seq_Bcells_Human1.31748008
55TAF15_26573619_Chip-Seq_HEK293_Human1.31343394
56ETV1_20927104_ChIP-Seq_GIST48_Human1.31257232
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.31156952
58SMAD3_21741376_ChIP-Seq_ESCs_Human1.30004423
59SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29909409
60LXR_22292898_ChIP-Seq_THP-1_Human1.29117393
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.29089749
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28799357
63ERG_20517297_ChIP-Seq_VCAP_Human1.26653102
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25427464
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24395727
66NFYB_21822215_ChIP-Seq_K562_Human1.23888069
67P300_19829295_ChIP-Seq_ESCs_Human1.23551983
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21015292
69TBL1_22424771_ChIP-Seq_293T_Human1.20616632
70P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.20320158
71CEBPB_22108803_ChIP-Seq_LS180_Human1.20224818
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18918338
73ZNF274_21170338_ChIP-Seq_K562_Hela1.18761209
74SOX2_22085726_ChIP-Seq_NPCs_Mouse1.18338337
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18250581
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.18194519
77KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.17784104
78RUNX_20019798_ChIP-Seq_JUKART_Human1.16114358
79P53_21459846_ChIP-Seq_SAOS-2_Human1.15793695
80PHF8_20622853_ChIP-Seq_HELA_Human1.15635117
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15584201
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15488674
83SMAD4_21741376_ChIP-Seq_HESCs_Human1.13375244
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12132599
85RUNX2_22187159_ChIP-Seq_PCA_Human1.10478655
86RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10333483
87GATA6_21074721_ChIP-Seq_CACO-2_Human1.09688051
88SA1_27219007_Chip-Seq_Bcells_Human1.08351300
89SMRT_27268052_Chip-Seq_Bcells_Human1.07106884
90HOXB7_26014856_ChIP-Seq_BT474_Human1.06132666
91NANOG_19829295_ChIP-Seq_ESCs_Human1.04343075
92SOX2_19829295_ChIP-Seq_ESCs_Human1.04343075
93PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03076922
94NFYA_21822215_ChIP-Seq_K562_Human1.02063518
95AR_21572438_ChIP-Seq_LNCaP_Human1.01735470
96EZH2_27294783_Chip-Seq_ESCs_Mouse1.01169662
97OCT1_27270436_Chip-Seq_PROSTATE_Human1.00054105
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99966594
99E2F1_17053090_ChIP-ChIP_MCF-7_Human0.99746238
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97131956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology5.20895593
2MP0005377_hearing/vestibular/ear_phenot5.20895593
3MP0003698_abnormal_male_reproductive4.57077382
4MP0005670_abnormal_white_adipose4.27364145
5MP0001929_abnormal_gametogenesis4.00942791
6MP0001348_abnormal_lacrimal_gland3.59038653
7MP0000678_abnormal_parathyroid_gland2.76350163
8MP0002161_abnormal_fertility/fecundity2.52629155
9MP0003718_maternal_effect2.27286304
10MP0003011_delayed_dark_adaptation2.24358967
11MP0002132_abnormal_respiratory_system2.11489480
12MP0003646_muscle_fatigue2.07615652
13MP0005410_abnormal_fertilization12.2450894
14MP0002210_abnormal_sex_determination1.92848509
15MP0005379_endocrine/exocrine_gland_phen1.78259371
16MP0005423_abnormal_somatic_nervous1.61103621
17MP0002249_abnormal_larynx_morphology1.60185405
18MP0004510_myositis1.59826594
19MP0002234_abnormal_pharynx_morphology1.57699564
20MP0001145_abnormal_male_reproductive1.57235718
21MP0001485_abnormal_pinna_reflex1.56370069
22MP0001486_abnormal_startle_reflex1.56215685
23MP0005310_abnormal_salivary_gland1.51237657
24MP0002282_abnormal_trachea_morphology1.49390371
25MP0000653_abnormal_sex_gland1.47391894
26MP0008877_abnormal_DNA_methylation1.38101085
27MP0009053_abnormal_anal_canal1.38087663
28MP0004742_abnormal_vestibular_system1.36945491
29MP0005451_abnormal_body_composition1.24814026
30MP0001765_abnormal_ion_homeostasis1.21582578
31MP0003879_abnormal_hair_cell1.18167152
32MP0001968_abnormal_touch/_nociception1.15510876
33MP0002138_abnormal_hepatobiliary_system1.14525101
34MP0004859_abnormal_synaptic_plasticity1.14081446
35MP0002735_abnormal_chemical_nociception1.12842615
36MP0001963_abnormal_hearing_physiology1.11848025
37MP0000534_abnormal_ureter_morphology1.09557714
38MP0005248_abnormal_Harderian_gland1.07058466
39MP0002127_abnormal_cardiovascular_syste1.07050333
40MP0002822_catalepsy1.05624206
41MP0005395_other_phenotype1.01244133
42MP0000026_abnormal_inner_ear0.99789817
43MP0002229_neurodegeneration0.82752712
44MP0000955_abnormal_spinal_cord0.82311379
45MP0000681_abnormal_thyroid_gland0.81298523
46MP0008995_early_reproductive_senescence0.80694519
47MP0002733_abnormal_thermal_nociception0.76772016
48MP0005551_abnormal_eye_electrophysiolog0.76478216
49MP0002067_abnormal_sensory_capabilities0.74981326
50MP0000049_abnormal_middle_ear0.74402949
51MP0004085_abnormal_heartbeat0.73774118
52MP0009115_abnormal_fat_cell0.72750782
53MP0005167_abnormal_blood-brain_barrier0.72363677
54MP0001984_abnormal_olfaction0.70068592
55MP0005666_abnormal_adipose_tissue0.69421848
56MP0008569_lethality_at_weaning0.68325673
57MP0005367_renal/urinary_system_phenotyp0.65081918
58MP0000516_abnormal_urinary_system0.65081918
59MP0009697_abnormal_copulation0.64968455
60MP0005083_abnormal_biliary_tract0.64022260
61MP0005636_abnormal_mineral_homeostasis0.63369784
62MP0005253_abnormal_eye_physiology0.63161529
63MP0001879_abnormal_lymphatic_vessel0.60770814
64MP0005375_adipose_tissue_phenotype0.58713134
65MP0002557_abnormal_social/conspecific_i0.58204750
66MP0004233_abnormal_muscle_weight0.58057022
67MP0002572_abnormal_emotion/affect_behav0.57150570
68MP0001905_abnormal_dopamine_level0.55938922
69MP0001666_abnormal_nutrient_absorption0.55594378
70MP0003119_abnormal_digestive_system0.53418704
71MP0004484_altered_response_of0.52976225
72MP0005623_abnormal_meninges_morphology0.52374201
73MP0003077_abnormal_cell_cycle0.52220758
74MP0001970_abnormal_pain_threshold0.51104759
75MP0000003_abnormal_adipose_tissue0.51033963
76MP0004036_abnormal_muscle_relaxation0.48266011
77MP0002653_abnormal_ependyma_morphology0.47355851
78MP0002272_abnormal_nervous_system0.47013168
79MP0001440_abnormal_grooming_behavior0.45847170
80MP0003699_abnormal_female_reproductive0.44622371
81MP0001501_abnormal_sleep_pattern0.44486587
82MP0003137_abnormal_impulse_conducting0.44338391
83MP0002734_abnormal_mechanical_nocicepti0.43419024
84MP0005535_abnormal_body_temperature0.42780244
85MP0009745_abnormal_behavioral_response0.41816751
86MP0000470_abnormal_stomach_morphology0.40109815
87MP0002928_abnormal_bile_duct0.39740879
88MP0003936_abnormal_reproductive_system0.39592867
89MP0000249_abnormal_blood_vessel0.38760629
90MP0003172_abnormal_lysosome_physiology0.37378534
91MP0000230_abnormal_systemic_arterial0.36936277
92MP0005647_abnormal_sex_gland0.36668617
93MP0008961_abnormal_basal_metabolism0.34782292
94MP0003880_abnormal_central_pattern0.34473549
95MP0008789_abnormal_olfactory_epithelium0.33817079
96MP0006292_abnormal_olfactory_placode0.33408308
97MP0003635_abnormal_synaptic_transmissio0.32610283
98MP0005408_hypopigmentation0.32531753
99MP0005391_vision/eye_phenotype0.28662320
100MP0002882_abnormal_neuron_morphology0.28662030

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.46554041
2Absent/shortened dynein arms (HP:0200106)5.92046109
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.92046109
4Asymmetric septal hypertrophy (HP:0001670)5.63882440
5Attenuation of retinal blood vessels (HP:0007843)5.10839784
6Bony spicule pigmentary retinopathy (HP:0007737)5.10056263
7Tubulointerstitial nephritis (HP:0001970)4.94362483
8Resting tremor (HP:0002322)4.86114409
9Bell-shaped thorax (HP:0001591)4.68070825
10Abnormal ciliary motility (HP:0012262)4.55233571
11Abnormal respiratory motile cilium physiology (HP:0012261)4.47921628
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.41461598
13Hypoplastic ischia (HP:0003175)4.35904281
14Chronic hepatic failure (HP:0100626)4.33745684
15Male infertility (HP:0003251)4.33618576
16Abnormal respiratory epithelium morphology (HP:0012253)4.19917100
17Abnormal respiratory motile cilium morphology (HP:0005938)4.19917100
18Infertility (HP:0000789)4.15067915
19Nasal polyposis (HP:0100582)4.10100758
20Enlarged epiphyses (HP:0010580)4.09052184
21Hyperkalemia (HP:0002153)4.08525888
22Abnormal rod and cone electroretinograms (HP:0008323)4.04527016
23Abnormality of macular pigmentation (HP:0008002)3.94827022
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.93317739
25Abnormality of the ischium (HP:0003174)3.87384098
26Aplasia/Hypoplasia of the earlobes (HP:0009906)3.77858277
27Facial shape deformation (HP:0011334)3.74444289
28Potter facies (HP:0002009)3.74444289
29Azoospermia (HP:0000027)3.63848580
30Abnormal spermatogenesis (HP:0008669)3.60020454
31Cone-rod dystrophy (HP:0000548)3.58758902
32Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.43689187
33Abnormality of the nasal mucosa (HP:0000433)3.31419830
34Impulsivity (HP:0100710)3.24104473
35Hypoplasia of the thymus (HP:0000778)3.10829298
36Postural instability (HP:0002172)3.04099948
37Unilateral renal agenesis (HP:0000122)2.94779590
38Progressive sensorineural hearing impairment (HP:0000408)2.81956646
39Stage 5 chronic kidney disease (HP:0003774)2.79190058
40Nephronophthisis (HP:0000090)2.73305079
41Abnormal urine output (HP:0012590)2.68393936
42Generalized aminoaciduria (HP:0002909)2.63364390
43Hypoalphalipoproteinemia (HP:0003233)2.61417719
44Rhinitis (HP:0012384)2.60475413
45Double outlet right ventricle (HP:0001719)2.59184320
46Congenital malformation of the right heart (HP:0011723)2.59184320
47Truncal obesity (HP:0001956)2.57917017
48Progressive cerebellar ataxia (HP:0002073)2.53856235
49Abnormality of the aortic arch (HP:0012303)2.53708988
50Abnormality of dental color (HP:0011073)2.49914092
51Amelogenesis imperfecta (HP:0000705)2.49651410
52Flattened epiphyses (HP:0003071)2.49361920
53Abnormality of the costochondral junction (HP:0000919)2.49276023
54Epiphyseal dysplasia (HP:0002656)2.44514751
55Renal dysplasia (HP:0000110)2.43517843
56Abnormality of potassium homeostasis (HP:0011042)2.41749504
57Portal hypertension (HP:0001409)2.41646866
58Abnormality of the renal medulla (HP:0100957)2.35520563
59Menstrual irregularities (HP:0000858)2.34431227
60Tubulointerstitial abnormality (HP:0001969)2.34329686
61Abnormality of renal excretion (HP:0011036)2.33848195
62Absent epiphyses (HP:0010577)2.32535036
63Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.32535036
64Polydipsia (HP:0001959)2.30910694
65Abnormal drinking behavior (HP:0030082)2.30910694
66Insulin-resistant diabetes mellitus (HP:0000831)2.28776744
67Osteomalacia (HP:0002749)2.24342659
68Ventricular tachycardia (HP:0004756)2.21913660
69Abnormality of the hepatic vasculature (HP:0006707)2.20645504
70Renovascular hypertension (HP:0100817)2.19523384
71Abnormality of the pubic bones (HP:0003172)2.13312759
72Polyuria (HP:0000103)2.12615576
73Abnormality of the epiphysis of the femoral head (HP:0010574)2.12318621
74Intellectual disability, moderate (HP:0002342)2.07721746
75Horizontal nystagmus (HP:0000666)2.07614076
76Abnormality of the parathyroid morphology (HP:0011766)2.06326695
77Focal segmental glomerulosclerosis (HP:0000097)2.03540977
78Bronchiectasis (HP:0002110)2.01321537
79Abnormality of femoral epiphyses (HP:0006499)1.98361010
80Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.98361010
81Hyponatremia (HP:0002902)1.97278909
82Hypophosphatemic rickets (HP:0004912)1.96039447
83Decreased central vision (HP:0007663)1.95084898
84Widely patent fontanelles and sutures (HP:0004492)1.94632763
85Chronic bronchitis (HP:0004469)1.93232109
86Recurrent pneumonia (HP:0006532)1.91490044
87Abnormality of the femoral head (HP:0003368)1.87655969
88Protuberant abdomen (HP:0001538)1.86346104
89Progressive hearing impairment (HP:0001730)1.81677115
90Mixed hearing impairment (HP:0000410)1.80980200
91Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80460712
92Flat capital femoral epiphysis (HP:0003370)1.80334008
93Short ribs (HP:0000773)1.79833226
94Bradycardia (HP:0001662)1.79722830
95Tetany (HP:0001281)1.77958790
96Recurrent corneal erosions (HP:0000495)1.77706586
97Optic nerve hypoplasia (HP:0000609)1.76794830
98Hyperuricemia (HP:0002149)1.75983536
99Increased purine levels (HP:0004368)1.75983536
100Spastic paraparesis (HP:0002313)1.75521601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.80021622
2TESK15.65693735
3DDR25.28694791
4INSRR4.42438658
5MAP4K23.49098632
6PNCK3.42106599
7PLK23.35769429
8BRD43.16287371
9STK382.71652103
10CAMK1G2.35439510
11STK38L2.14224063
12MAPK152.06640566
13PIK3CG1.93470621
14PRKD31.88036342
15MST1R1.82026671
16WNK11.77630929
17PDPK11.51407582
18PDK11.45645763
19PTK2B1.44752114
20CDK121.38211936
21CDK71.30481772
22DYRK1B1.12075283
23MAP3K91.11992483
24NEK61.10959168
25KSR21.09103155
26TYRO30.84594459
27BRAF0.75745196
28CAMK1D0.73917159
29PRKG20.73737896
30AKT30.72455052
31LATS20.71341443
32UHMK10.69132052
33MET0.67574756
34RPS6KA20.65023720
35MAP3K110.62926766
36PRKG10.62501794
37PRKAA20.62279486
38MAP3K20.62217358
39MAP2K20.56181603
40CDK30.55819383
41RPS6KA10.54680425
42SIK20.53672806
43CAMK10.53578260
44ROCK10.53483758
45MAP3K80.47946915
46MUSK0.44676167
47CDK40.44580572
48ARAF0.43996653
49LATS10.42455108
50CDK20.40421713
51GSK3B0.39863689
52MAPK10.38653582
53CDK10.37377564
54PINK10.36761307
55TIE10.35167216
56RPS6KL10.34550960
57RPS6KC10.34550960
58SGK4940.32676747
59SGK2230.32676747
60PRKCG0.32360124
61STK390.32199372
62OXSR10.32142543
63WNK40.31256767
64RPS6KA60.31182787
65NTRK30.31125634
66CHEK10.30965234
67MTOR0.30629697
68CAMK40.29794272
69MARK10.29671667
70MAP3K10.28815697
71PRKCZ0.28376619
72MAPK80.27742409
73BMPR1B0.25639443
74SGK10.24988152
75BRSK10.23651073
76MAP3K40.22981119
77MARK20.21965150
78MAPK140.19544912
79PRKCB0.19229925
80MAPK100.19191986
81MAP3K130.19099111
82MAPK110.18072891
83TESK20.16868487
84CDK190.16241443
85PKN10.15267564
86BLK0.15140474
87AKT10.14165970
88JAK30.13773910
89FRK0.13748471
90DYRK30.12760422
91PRKACB0.06675768
92SGK20.05856897
93RIPK40.05732915
94MAPK90.05250892
95PRKAA10.04923296
96PRKACA0.04725659
97CAMK2A0.04382978
98MAP3K70.04152192
99IKBKB0.03842622
100RPS6KA30.03521813

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.68411143
2Fatty acid biosynthesis_Homo sapiens_hsa000615.62514109
3Olfactory transduction_Homo sapiens_hsa047403.92565759
4Butanoate metabolism_Homo sapiens_hsa006502.58182161
5Allograft rejection_Homo sapiens_hsa053302.11589385
6Autoimmune thyroid disease_Homo sapiens_hsa053202.04711034
7Type I diabetes mellitus_Homo sapiens_hsa049402.04354464
8Glycerophospholipid metabolism_Homo sapiens_hsa005642.01988575
9Graft-versus-host disease_Homo sapiens_hsa053321.92640437
10Dorso-ventral axis formation_Homo sapiens_hsa043201.83502901
11Antigen processing and presentation_Homo sapiens_hsa046121.82957180
12Taste transduction_Homo sapiens_hsa047421.79272766
13Phenylalanine metabolism_Homo sapiens_hsa003601.73598057
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68087207
15Type II diabetes mellitus_Homo sapiens_hsa049301.66414295
16RNA transport_Homo sapiens_hsa030131.65872175
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64605078
18Viral myocarditis_Homo sapiens_hsa054161.51243687
19Fatty acid degradation_Homo sapiens_hsa000711.43806477
20Fatty acid metabolism_Homo sapiens_hsa012121.25838659
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24293103
22Arginine and proline metabolism_Homo sapiens_hsa003301.21538503
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19474075
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18115310
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.17987316
26Protein digestion and absorption_Homo sapiens_hsa049741.17910770
27Endocytosis_Homo sapiens_hsa041441.09521109
28Adipocytokine signaling pathway_Homo sapiens_hsa049201.05692991
29Oocyte meiosis_Homo sapiens_hsa041141.05561489
30Salivary secretion_Homo sapiens_hsa049701.02238946
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02003065
32Arginine biosynthesis_Homo sapiens_hsa002200.98309919
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97658150
34Phototransduction_Homo sapiens_hsa047440.95581778
35Inositol phosphate metabolism_Homo sapiens_hsa005620.94141123
36Influenza A_Homo sapiens_hsa051640.93762854
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89525245
38Calcium signaling pathway_Homo sapiens_hsa040200.88140228
39cAMP signaling pathway_Homo sapiens_hsa040240.82180281
40Cardiac muscle contraction_Homo sapiens_hsa042600.79442934
41ABC transporters_Homo sapiens_hsa020100.78866373
42Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78252084
43Synaptic vesicle cycle_Homo sapiens_hsa047210.77866338
44Morphine addiction_Homo sapiens_hsa050320.76716310
45PPAR signaling pathway_Homo sapiens_hsa033200.74681132
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74533928
47Fat digestion and absorption_Homo sapiens_hsa049750.74113690
48Renin-angiotensin system_Homo sapiens_hsa046140.70784427
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70418154
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70085423
51Estrogen signaling pathway_Homo sapiens_hsa049150.69921312
52Nicotine addiction_Homo sapiens_hsa050330.69666257
53Hedgehog signaling pathway_Homo sapiens_hsa043400.69003254
54Tyrosine metabolism_Homo sapiens_hsa003500.68639791
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.65955385
56Retinol metabolism_Homo sapiens_hsa008300.65758395
57VEGF signaling pathway_Homo sapiens_hsa043700.63848734
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62597868
59Circadian entrainment_Homo sapiens_hsa047130.61879025
60Glycerolipid metabolism_Homo sapiens_hsa005610.61717776
61Glutamatergic synapse_Homo sapiens_hsa047240.57618099
62mRNA surveillance pathway_Homo sapiens_hsa030150.56814150
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55145683
64Selenocompound metabolism_Homo sapiens_hsa004500.54104962
65Gastric acid secretion_Homo sapiens_hsa049710.53198649
66Renin secretion_Homo sapiens_hsa049240.52432917
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.51833189
68MAPK signaling pathway_Homo sapiens_hsa040100.49794110
69Bile secretion_Homo sapiens_hsa049760.48552359
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47109913
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46857066
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.45701821
73Insulin secretion_Homo sapiens_hsa049110.44029355
74Acute myeloid leukemia_Homo sapiens_hsa052210.41090708
75Purine metabolism_Homo sapiens_hsa002300.40893491
76Cholinergic synapse_Homo sapiens_hsa047250.37661828
77Basal transcription factors_Homo sapiens_hsa030220.37204829
78Serotonergic synapse_Homo sapiens_hsa047260.37097862
79Pancreatic secretion_Homo sapiens_hsa049720.35192338
80Fanconi anemia pathway_Homo sapiens_hsa034600.34715512
81Herpes simplex infection_Homo sapiens_hsa051680.33462894
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.33089363
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31488833
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30859526
85Tight junction_Homo sapiens_hsa045300.30544596
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29377653
87ECM-receptor interaction_Homo sapiens_hsa045120.28733529
88Viral carcinogenesis_Homo sapiens_hsa052030.28035294
89Oxytocin signaling pathway_Homo sapiens_hsa049210.27863457
90Long-term potentiation_Homo sapiens_hsa047200.27826299
91Nitrogen metabolism_Homo sapiens_hsa009100.27449705
92Prolactin signaling pathway_Homo sapiens_hsa049170.26621606
93GABAergic synapse_Homo sapiens_hsa047270.22550854
94B cell receptor signaling pathway_Homo sapiens_hsa046620.20407993
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18883924
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18342227
97Toxoplasmosis_Homo sapiens_hsa051450.17511200
98Choline metabolism in cancer_Homo sapiens_hsa052310.15234519
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.14933277
100Sulfur relay system_Homo sapiens_hsa041220.13511548

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