ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	plasma membrane fusion (GO:0045026)	8.39432398
2	chromosome condensation (GO:0030261)	8.34014029
3	sperm capacitation (GO:0048240)	8.13619968
4	DNA packaging (GO:0006323)	7.98523312
5	spermatid development (GO:0007286)	7.97901387
6	response to pheromone (GO:0019236)	7.91870786
7	microtubule depolymerization (GO:0007019)	7.70484635
8	multicellular organism reproduction (GO:0032504)	7.47773924
9	sperm-egg recognition (GO:0035036)	7.46981692
10	single strand break repair (GO:0000012)	7.22245060
11	spermatid nucleus differentiation (GO:0007289)	7.18656624
12	binding of sperm to zona pellucida (GO:0007339)	6.90297982
13	reproduction (GO:0000003)	6.76086669
14	protein polyglutamylation (GO:0018095)	6.54993030
15	microtubule polymerization or depolymerization (GO:0031109)	6.39387553
16	rRNA methylation (GO:0031167)	6.37951101
17	calcium ion-dependent exocytosis (GO:0017156)	6.36732559
18	negative regulation of inclusion body assembly (GO:0090084)	6.15515892
19	cell-cell recognition (GO:0009988)	6.12977398
20	protein targeting to Golgi (GO:0000042)	6.09465475
21	microtubule severing (GO:0051013)	6.04371373
22	* spermatogenesis (GO:0007283)	6.03144330
23	* male gamete generation (GO:0048232)	6.01147176
24	axonemal dynein complex assembly (GO:0070286)	5.94179813
25	establishment of protein localization to Golgi (GO:0072600)	5.87977671
26	sexual reproduction (GO:0019953)	5.77708975
27	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.71432394
28	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.63884226
29	cellular ketone body metabolic process (GO:0046950)	5.57319312
30	* gamete generation (GO:0007276)	5.51304973
31	rRNA modification (GO:0000154)	5.28846073
32	phosphatidylethanolamine metabolic process (GO:0046337)	5.27570999
33	single fertilization (GO:0007338)	5.18687430
34	glomerular visceral epithelial cell development (GO:0072015)	5.04820411
35	ketone body metabolic process (GO:1902224)	4.90586701
36	regulation of female receptivity (GO:0045924)	4.84752476
37	centriole replication (GO:0007099)	4.77917728
38	cilium or flagellum-dependent cell motility (GO:0001539)	4.73724723
39	glomerular epithelial cell development (GO:0072310)	4.71543862
40	regulation of cilium movement (GO:0003352)	4.70314725
41	regulation of Rab GTPase activity (GO:0032313)	4.68490375
42	positive regulation of Rab GTPase activity (GO:0032851)	4.68490375
43	protein localization to Golgi apparatus (GO:0034067)	4.53402907
44	motile cilium assembly (GO:0044458)	4.53209901
45	* multicellular organismal reproductive process (GO:0048609)	4.48840416
46	germ cell development (GO:0007281)	4.45165693
47	fertilization (GO:0009566)	4.29331830
48	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.26552043
49	regulation of inclusion body assembly (GO:0090083)	4.25004531
50	centriole assembly (GO:0098534)	4.24077405
51	female mating behavior (GO:0060180)	4.17758032
52	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.11386237
53	coenzyme catabolic process (GO:0009109)	3.98953839
54	RNA destabilization (GO:0050779)	3.97750552
55	epithelial cilium movement (GO:0003351)	3.97306458
56	regulation of centriole replication (GO:0046599)	3.96992967
57	seminiferous tubule development (GO:0072520)	3.94605072
58	chromatin silencing (GO:0006342)	3.89884811
59	regulation of transcription involved in cell fate commitment (GO:0060850)	3.70726006
60	response to acidic pH (GO:0010447)	3.70702993
61	negative regulation of Rho protein signal transduction (GO:0035024)	3.68689784
62	nucleus organization (GO:0006997)	3.66264931
63	cell wall macromolecule catabolic process (GO:0016998)	3.59336981
64	cilium movement (GO:0003341)	3.54391785
65	cellular response to pH (GO:0071467)	3.52106422
66	organic cation transport (GO:0015695)	3.44647069
67	musculoskeletal movement (GO:0050881)	3.40129304
68	multicellular organismal movement (GO:0050879)	3.40129304
69	regulation of microtubule-based movement (GO:0060632)	3.39524381
70	cell wall macromolecule metabolic process (GO:0044036)	3.32770071
71	polyamine biosynthetic process (GO:0006596)	3.25814587
72	glycerol ether metabolic process (GO:0006662)	3.17574340
73	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.16442698
74	microtubule nucleation (GO:0007020)	3.13478261
75	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.11560844
76	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.04558087
77	protein-chromophore linkage (GO:0018298)	2.98241670
78	NAD biosynthetic process (GO:0009435)	2.97747161
79	cell recognition (GO:0008037)	2.97171827
80	cerebral cortex neuron differentiation (GO:0021895)	2.96504578
81	membrane protein intracellular domain proteolysis (GO:0031293)	2.95022752
82	multicellular organismal development (GO:0007275)	2.93561631
83	male meiosis (GO:0007140)	2.91806803
84	ether metabolic process (GO:0018904)	2.91658312
85	peptidyl-threonine dephosphorylation (GO:0035970)	2.81634939
86	cranial nerve morphogenesis (GO:0021602)	2.81193615
87	piRNA metabolic process (GO:0034587)	2.78627417
88	myoblast fusion (GO:0007520)	2.78464142
89	nucleosome disassembly (GO:0006337)	2.72130199
90	protein-DNA complex disassembly (GO:0032986)	2.72130199
91	histone H3-K9 demethylation (GO:0033169)	2.69276156
92	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.68597384
93	cellular biogenic amine biosynthetic process (GO:0042401)	2.67879260
94	protein depolymerization (GO:0051261)	2.62552797
95	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.61132122
96	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.61132122
97	homeostasis of number of cells within a tissue (GO:0048873)	2.60861252
98	acrosome reaction (GO:0007340)	11.1934382
99	sperm motility (GO:0030317)	11.1725063
100	fusion of sperm to egg plasma membrane (GO:0007342)	11.1335493

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.42586024
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.19569067
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.03859786
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.88729647
5	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.70477466
6	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.70477466
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.31827952
8	FUS_26573619_Chip-Seq_HEK293_Human	2.25471028
9	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.12011738
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06400132
11	DROSHA_22980978_ChIP-Seq_HELA_Human	2.05052693
12	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.99395675
13	CBP_20019798_ChIP-Seq_JUKART_Human	1.99395675
14	ERA_21632823_ChIP-Seq_H3396_Human	1.83677537
15	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.82825160
16	RAC3_21632823_ChIP-Seq_H3396_Human	1.77931504
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.75984188
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.74960490
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.73207600
20	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.70822543
21	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.70557559
22	NANOG_20526341_ChIP-Seq_ESCs_Human	1.60501932
23	P300_19829295_ChIP-Seq_ESCs_Human	1.59331110
24	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.58314632
25	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.57108967
26	MYC_19829295_ChIP-Seq_ESCs_Human	1.53771622
27	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.52548744
28	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.52064427
29	CTCF_27219007_Chip-Seq_Bcells_Human	1.50766760
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50760822
31	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.49834655
32	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.48630315
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47611327
34	TAF2_19829295_ChIP-Seq_ESCs_Human	1.45120040
35	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.44121216
36	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.43944818
37	VDR_22108803_ChIP-Seq_LS180_Human	1.43265776
38	AR_25329375_ChIP-Seq_VCAP_Human	1.42320372
39	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.41321650
40	E2F1_20622854_ChIP-Seq_HELA_Human	1.41015996
41	TP53_18474530_ChIP-ChIP_U2OS_Human	1.40952949
42	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.39998063
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.38781076
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36781963
45	ZNF274_21170338_ChIP-Seq_K562_Hela	1.35652870
46	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.35152264
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34802431
48	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.32586125
49	OCT4_20526341_ChIP-Seq_ESCs_Human	1.32326550
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32134976
51	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.31085564
52	BCL6_27268052_Chip-Seq_Bcells_Human	1.28828011
53	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.28812898
54	TP63_22573176_ChIP-Seq_HFKS_Human	1.27257825
55	GBX2_23144817_ChIP-Seq_PC3_Human	1.26948030
56	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.26133775
57	PHF8_20622854_ChIP-Seq_HELA_Human	1.25755348
58	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.24859258
59	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.24787474
60	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22211152
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21299431
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21299431
63	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.21027335
64	BCOR_27268052_Chip-Seq_Bcells_Human	1.20624894
65	ERG_20517297_ChIP-Seq_VCAP_Human	1.20062296
66	AR_21572438_ChIP-Seq_LNCaP_Human	1.19994398
67	P53_21459846_ChIP-Seq_SAOS-2_Human	1.18903888
68	CTCF_20526341_ChIP-Seq_ESCs_Human	1.18495508
69	ETV1_20927104_ChIP-Seq_GIST48_Human	1.18463350
70	STAT3_23295773_ChIP-Seq_U87_Human	1.18287596
71	RBPJ_21746931_ChIP-Seq_IB4_Human	1.18031170
72	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.17612427
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17348207
74	TBL1_22424771_ChIP-Seq_293T_Human	1.15689844
75	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15333110
76	SMC4_20622854_ChIP-Seq_HELA_Human	1.15288622
77	CEBPB_22108803_ChIP-Seq_LS180_Human	1.14908221
78	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14815478
79	NFYB_21822215_ChIP-Seq_K562_Human	1.14708855
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13722330
81	TAF15_26573619_Chip-Seq_HEK293_Human	1.12408134
82	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.12270596
83	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.11635823
84	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.11552777
85	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.11407718
86	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.10233856
87	P68_20966046_ChIP-Seq_HELA_Human	1.09286149
88	PHF8_20622853_ChIP-Seq_HELA_Human	1.08770715
89	SMRT_27268052_Chip-Seq_Bcells_Human	1.08000305
90	P300_27268052_Chip-Seq_Bcells_Human	1.07446071
91	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.07054267
92	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.06532844
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05994720
94	LXR_22292898_ChIP-Seq_THP-1_Human	1.04893010
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03553049
96	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02711846
97	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.02055861
98	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.01884018
99	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01055960
100	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.99019800

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	4.26990526
2	MP0003878_abnormal_ear_physiology	4.26990526
3	MP0003698_abnormal_male_reproductive	4.00904910
4	MP0005670_abnormal_white_adipose	3.83447174
5	MP0002132_abnormal_respiratory_system	3.41952974
6	MP0001929_abnormal_gametogenesis	3.37909252
7	MP0001348_abnormal_lacrimal_gland	3.31475996
8	MP0003136_yellow_coat_color	3.13697508
9	MP0009780_abnormal_chondrocyte_physiolo	3.07976416
10	MP0005379_endocrine/exocrine_gland_phen	2.48612852
11	MP0003879_abnormal_hair_cell	2.39852922
12	MP0003646_muscle_fatigue	2.23161101
13	MP0002161_abnormal_fertility/fecundity	2.12672042
14	MP0003011_delayed_dark_adaptation	2.11586094
15	MP0003718_maternal_effect	2.05183213
16	MP0005410_abnormal_fertilization	11.1650085
17	MP0001485_abnormal_pinna_reflex	1.87294464
18	MP0002282_abnormal_trachea_morphology	1.70463897
19	MP0000678_abnormal_parathyroid_gland	1.70242937
20	MP0001968_abnormal_touch/_nociception	1.69710857
21	MP0001486_abnormal_startle_reflex	1.67652814
22	MP0002210_abnormal_sex_determination	1.62021847
23	MP0002138_abnormal_hepatobiliary_system	1.53681847
24	MP0004742_abnormal_vestibular_system	1.47803654
25	MP0002249_abnormal_larynx_morphology	1.47330025
26	MP0002163_abnormal_gland_morphology	1.41954310
27	MP0000372_irregular_coat_pigmentation	1.38356706
28	MP0005423_abnormal_somatic_nervous	1.38268103
29	MP0002735_abnormal_chemical_nociception	1.33042002
30	MP0001963_abnormal_hearing_physiology	1.28864299
31	MP0005551_abnormal_eye_electrophysiolog	1.20777299
32	MP0001145_abnormal_male_reproductive	1.19320698
33	MP0002234_abnormal_pharynx_morphology	1.18642230
34	MP0000653_abnormal_sex_gland	1.18572262
35	MP0000681_abnormal_thyroid_gland	1.16672214
36	MP0008877_abnormal_DNA_methylation	1.15873743
37	MP0005310_abnormal_salivary_gland	1.15522876
38	MP0006276_abnormal_autonomic_nervous	1.12823164
39	MP0000534_abnormal_ureter_morphology	1.09383431
40	MP0000026_abnormal_inner_ear	1.06226684
41	MP0002822_catalepsy	1.04041554
42	MP0001765_abnormal_ion_homeostasis	1.03995001
43	MP0000049_abnormal_middle_ear	0.98148911
44	MP0004085_abnormal_heartbeat	0.96574881
45	MP0009053_abnormal_anal_canal	0.96478946
46	MP0005395_other_phenotype	0.96163497
47	MP0001501_abnormal_sleep_pattern	0.94391209
48	MP0000230_abnormal_systemic_arterial	0.92798910
49	MP0002653_abnormal_ependyma_morphology	0.92387941
50	MP0004859_abnormal_synaptic_plasticity	0.92305479
51	MP0004510_myositis	0.91486235
52	MP0004885_abnormal_endolymph	0.88272497
53	MP0002733_abnormal_thermal_nociception	0.88071995
54	MP0003638_abnormal_response/metabolism_	0.83432339
55	MP0005253_abnormal_eye_physiology	0.82120910
56	MP0001984_abnormal_olfaction	0.82013899
57	MP0002067_abnormal_sensory_capabilities	0.80413311
58	MP0002229_neurodegeneration	0.80319548
59	MP0002572_abnormal_emotion/affect_behav	0.79953110
60	MP0005248_abnormal_Harderian_gland	0.79405344
61	MP0005083_abnormal_biliary_tract	0.79020726
62	MP0005187_abnormal_penis_morphology	0.76552469
63	MP0009697_abnormal_copulation	0.76390688
64	MP0002557_abnormal_social/conspecific_i	0.73571045
65	MP0002272_abnormal_nervous_system	0.73451981
66	MP0003119_abnormal_digestive_system	0.73362491
67	MP0009745_abnormal_behavioral_response	0.69106776
68	MP0005451_abnormal_body_composition	0.68042561
69	MP0001970_abnormal_pain_threshold	0.67374089
70	MP0008775_abnormal_heart_ventricle	0.66500529
71	MP0003137_abnormal_impulse_conducting	0.65240636
72	MP0002734_abnormal_mechanical_nocicepti	0.64118313
73	MP0003938_abnormal_ear_development	0.63932673
74	MP0005167_abnormal_blood-brain_barrier	0.63738565
75	MP0002736_abnormal_nociception_after	0.63432407
76	MP0002127_abnormal_cardiovascular_syste	0.61866449
77	MP0008961_abnormal_basal_metabolism	0.60597244
78	MP0000955_abnormal_spinal_cord	0.59649215
79	MP0005636_abnormal_mineral_homeostasis	0.55780312
80	MP0010329_abnormal_lipoprotein_level	0.52904171
81	MP0000470_abnormal_stomach_morphology	0.51718073
82	MP0001879_abnormal_lymphatic_vessel	0.50910825
83	MP0003880_abnormal_central_pattern	0.50864742
84	MP0005535_abnormal_body_temperature	0.50690127
85	MP0005595_abnormal_vascular_smooth	0.49993276
86	MP0009046_muscle_twitch	0.48757553
87	MP0008995_early_reproductive_senescence	0.48629232
88	MP0003635_abnormal_synaptic_transmissio	0.47588791
89	MP0009115_abnormal_fat_cell	0.45449689
90	MP0004381_abnormal_hair_follicle	0.43709416
91	MP0002928_abnormal_bile_duct	0.43554228
92	MP0005360_urolithiasis	0.43478891
93	MP0005367_renal/urinary_system_phenotyp	0.42582438
94	MP0000516_abnormal_urinary_system	0.42582438
95	MP0008872_abnormal_physiological_respon	0.41844935
96	MP0003631_nervous_system_phenotype	0.41689147
97	MP0005645_abnormal_hypothalamus_physiol	0.41424067
98	MP0005084_abnormal_gallbladder_morpholo	0.39297241
99	MP0001905_abnormal_dopamine_level	0.38844097
100	MP0003633_abnormal_nervous_system	0.37417610

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	9.32479779
2	Absent/shortened dynein arms (HP:0200106)	5.71046271
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.71046271
4	Attenuation of retinal blood vessels (HP:0007843)	5.53243460
5	Bony spicule pigmentary retinopathy (HP:0007737)	5.31616276
6	Abnormal rod and cone electroretinograms (HP:0008323)	5.05562839
7	Abnormality of macular pigmentation (HP:0008002)	4.55224617
8	Abnormal ciliary motility (HP:0012262)	4.44726976
9	Abnormal respiratory motile cilium physiology (HP:0012261)	4.40236029
10	Tubulointerstitial nephritis (HP:0001970)	4.33055240
11	Chronic hepatic failure (HP:0100626)	4.24607420
12	Asymmetric septal hypertrophy (HP:0001670)	4.18359735
13	Abnormal respiratory motile cilium morphology (HP:0005938)	4.14528796
14	Abnormal respiratory epithelium morphology (HP:0012253)	4.14528796
15	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.10530785
16	Hyperkalemia (HP:0002153)	3.96383793
17	Nasal polyposis (HP:0100582)	3.90958700
18	Cone-rod dystrophy (HP:0000548)	3.71187784
19	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.71043512
20	Potter facies (HP:0002009)	3.66762137
21	Facial shape deformation (HP:0011334)	3.66762137
22	Resting tremor (HP:0002322)	3.66702566
23	Infertility (HP:0000789)	3.60496763
24	Hypoplastic ischia (HP:0003175)	3.59938862
25	Enlarged epiphyses (HP:0010580)	3.40998629
26	Bell-shaped thorax (HP:0001591)	3.36900590
27	Abnormality of the ischium (HP:0003174)	3.21612017
28	Male infertility (HP:0003251)	3.21427038
29	Abnormality of the nasal mucosa (HP:0000433)	3.17527969
30	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.15921717
31	Azoospermia (HP:0000027)	3.02368116
32	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.90158948
33	Hypoplasia of the thymus (HP:0000778)	2.84658899
34	Tubular atrophy (HP:0000092)	2.84447641
35	Abnormal spermatogenesis (HP:0008669)	2.83890406
36	Impulsivity (HP:0100710)	2.74078034
37	Type II lissencephaly (HP:0007260)	2.73607929
38	Postural instability (HP:0002172)	2.72829194
39	Abnormality of dental color (HP:0011073)	2.67282136
40	Nephronophthisis (HP:0000090)	2.65769732
41	Amelogenesis imperfecta (HP:0000705)	2.65759297
42	Optic nerve hypoplasia (HP:0000609)	2.62968835
43	Cerebellar dysplasia (HP:0007033)	2.60330909
44	Rhinitis (HP:0012384)	2.54326021
45	Stage 5 chronic kidney disease (HP:0003774)	2.53768346
46	Abnormal urine output (HP:0012590)	2.50703910
47	Progressive sensorineural hearing impairment (HP:0000408)	2.49073540
48	Hypoalphalipoproteinemia (HP:0003233)	2.36715561
49	Polydipsia (HP:0001959)	2.34182943
50	Abnormal drinking behavior (HP:0030082)	2.34182943
51	Progressive cerebellar ataxia (HP:0002073)	2.31356591
52	Renovascular hypertension (HP:0100817)	2.30755949
53	Abnormality of the renal medulla (HP:0100957)	2.30484739
54	Tubulointerstitial abnormality (HP:0001969)	2.29596213
55	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.24802692
56	Generalized aminoaciduria (HP:0002909)	2.24591691
57	Abnormality of potassium homeostasis (HP:0011042)	2.24448616
58	Osteomalacia (HP:0002749)	2.24214193
59	Chronic bronchitis (HP:0004469)	2.22373319
60	Congenital stationary night blindness (HP:0007642)	2.20022306
61	Focal segmental glomerulosclerosis (HP:0000097)	2.16551953
62	Abnormality of renal excretion (HP:0011036)	2.16108630
63	Truncal obesity (HP:0001956)	2.15008427
64	Concave nail (HP:0001598)	2.10848963
65	Congenital malformation of the right heart (HP:0011723)	2.09425075
66	Double outlet right ventricle (HP:0001719)	2.09425075
67	Portal hypertension (HP:0001409)	2.09411279
68	Polyuria (HP:0000103)	2.08713661
69	Mesangial abnormality (HP:0001966)	2.06233571
70	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.05025316
71	Absent epiphyses (HP:0010577)	2.05025316
72	Renal dysplasia (HP:0000110)	2.05002382
73	Abnormal albumin level (HP:0012116)	2.04145243
74	Hypoalbuminemia (HP:0003073)	2.04145243
75	Decreased central vision (HP:0007663)	2.03362046
76	Abnormality of the parathyroid morphology (HP:0011766)	1.99447713
77	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.97063677
78	Bronchiectasis (HP:0002110)	1.96826581
79	Unilateral renal agenesis (HP:0000122)	1.96197559
80	Abnormality of the aortic arch (HP:0012303)	1.96166673
81	Photophobia (HP:0000613)	1.95978043
82	Retinal dysplasia (HP:0007973)	1.94269127
83	Abnormality of the femoral head (HP:0003368)	1.93257933
84	Flattened epiphyses (HP:0003071)	1.91963194
85	Intellectual disability, moderate (HP:0002342)	1.91406699
86	Abnormality of the hepatic vasculature (HP:0006707)	1.91262872
87	Hypophosphatemic rickets (HP:0004912)	1.90280682
88	Epiphyseal dysplasia (HP:0002656)	1.86033292
89	Ventricular tachycardia (HP:0004756)	1.85299282
90	Abnormality of the pubic bones (HP:0003172)	1.83841687
91	Abnormality of the costochondral junction (HP:0000919)	1.83371092
92	Insulin-resistant diabetes mellitus (HP:0000831)	1.82449407
93	Hyperthyroidism (HP:0000836)	1.82336319
94	Menstrual irregularities (HP:0000858)	1.81745298
95	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.81156852
96	Abnormality of femoral epiphyses (HP:0006499)	1.81156852
97	True hermaphroditism (HP:0010459)	1.80204793
98	Myokymia (HP:0002411)	1.76811907
99	Pendular nystagmus (HP:0012043)	1.76729622
100	Horizontal nystagmus (HP:0000666)	1.76709409

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.93645345
2	INSRR	5.26729974
3	TESK1	4.38127159
4	DDR2	4.21702471
5	MAP4K2	3.62044280
6	PLK2	3.26029799
7	STK38	3.13541754
8	PNCK	2.96763634
9	BRD4	2.92651174
10	CDK12	2.62559874
11	CAMK1G	2.13057762
12	FRK	2.11415114
13	STK38L	2.07120142
14	MAPK15	1.97590732
15	PIK3CG	1.93828381
16	PRKD3	1.77067287
17	PINK1	1.66059664
18	WNK1	1.53752158
19	MST1R	1.40669719
20	PDPK1	1.33660121
21	PDK1	1.31703036
22	PTK2B	1.23854694
23	LATS2	1.20211524
24	CDK7	1.10790032
25	TYRO3	1.06376638
26	ADRBK2	1.04266315
27	DYRK1B	1.03134614
28	NEK6	1.01074353
29	BMPR1B	0.90560905
30	KIT	0.88185215
31	MAP3K10	0.79358633
32	ROCK1	0.77901300
33	CAMK1D	0.76075565
34	WNK4	0.73385249
35	PRKAA2	0.70979932
36	PRKG2	0.70270308
37	SIK2	0.67957703
38	RPS6KA2	0.65983926
39	MAP3K9	0.65597387
40	PRKCG	0.59840512
41	MUSK	0.59057367
42	PRKG1	0.57067517
43	RPS6KA1	0.56472142
44	AKT3	0.54730059
45	CDK3	0.53673971
46	TIE1	0.53614164
47	STK39	0.53004811
48	CAMK1	0.52269631
49	MAP2K7	0.51317190
50	DAPK2	0.47623557
51	UHMK1	0.47087817
52	KSR2	0.46451158
53	GSK3B	0.45812692
54	RPS6KA6	0.43227811
55	IRAK3	0.43119095
56	BRAF	0.40803830
57	MAPK1	0.40767441
58	CDK2	0.39552301
59	MAP3K11	0.39524963
60	MARK1	0.39261546
61	MAP3K2	0.38742255
62	MAP3K1	0.38378862
63	CDK1	0.38333478
64	MAPK8	0.37473937
65	OXSR1	0.35921052
66	CHUK	0.34153397
67	MAP3K8	0.33068987
68	SGK223	0.32228324
69	SGK494	0.32228324
70	RPS6KC1	0.31858044
71	RPS6KL1	0.31858044
72	MTOR	0.31552623
73	AKT1	0.31093103
74	PRKCZ	0.31083524
75	MAP2K2	0.30829213
76	BRSK1	0.29538497
77	ERBB2	0.29105773
78	PRKCB	0.27696103
79	CAMK4	0.27176660
80	SGK1	0.27062823
81	MAPK14	0.26961577
82	ACVR1B	0.26525080
83	PRKCE	0.25131762
84	NTRK3	0.25125007
85	DYRK2	0.24114430
86	LATS1	0.23755716
87	CAMK2A	0.23020564
88	MAP3K4	0.22802946
89	FGFR2	0.20447975
90	CDK4	0.19309907
91	CDK5	0.19297399
92	TLK1	0.19128500
93	NEK2	0.19115803
94	PKN1	0.18759212
95	PRKACA	0.18714459
96	ADRBK1	0.18532438
97	TRPM7	0.15791554
98	MINK1	0.15562109
99	RPS6KA3	0.13733481
100	MAPK10	0.13597673

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	6.74837679
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.14405361
3	Olfactory transduction_Homo sapiens_hsa04740	3.96865183
4	Butanoate metabolism_Homo sapiens_hsa00650	2.81599484
5	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.08924358
6	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.08685070
7	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.02873310
8	Nicotine addiction_Homo sapiens_hsa05033	1.99139942
9	Taste transduction_Homo sapiens_hsa04742	1.92890525
10	Salivary secretion_Homo sapiens_hsa04970	1.81410550
11	Phenylalanine metabolism_Homo sapiens_hsa00360	1.74683992
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.69949634
13	Arginine and proline metabolism_Homo sapiens_hsa00330	1.67822432
14	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.66178307
15	Allograft rejection_Homo sapiens_hsa05330	1.50777346
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.46306700
17	Circadian entrainment_Homo sapiens_hsa04713	1.44870285
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.41689595
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.40305545
20	Calcium signaling pathway_Homo sapiens_hsa04020	1.36889815
21	Fatty acid degradation_Homo sapiens_hsa00071	1.36301311
22	Phototransduction_Homo sapiens_hsa04744	1.26613690
23	Type II diabetes mellitus_Homo sapiens_hsa04930	1.19839104
24	Morphine addiction_Homo sapiens_hsa05032	1.19636993
25	cAMP signaling pathway_Homo sapiens_hsa04024	1.17240311
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.16345326
27	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.13646237
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.11039279
29	Renin secretion_Homo sapiens_hsa04924	1.10006187
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.09515645
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.05864486
32	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.01189836
33	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.97250778
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95534202
35	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.95457195
36	Retinol metabolism_Homo sapiens_hsa00830	0.94925444
37	Tyrosine metabolism_Homo sapiens_hsa00350	0.93615666
38	Arginine biosynthesis_Homo sapiens_hsa00220	0.92548186
39	Glutamatergic synapse_Homo sapiens_hsa04724	0.91392011
40	ABC transporters_Homo sapiens_hsa02010	0.90722100
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.90330886
42	Protein digestion and absorption_Homo sapiens_hsa04974	0.90191320
43	Fatty acid metabolism_Homo sapiens_hsa01212	0.90107643
44	RNA transport_Homo sapiens_hsa03013	0.88736315
45	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87265324
46	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.86189794
47	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.86069381
48	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.82919186
49	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.82762727
50	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.77382938
51	Viral myocarditis_Homo sapiens_hsa05416	0.77139044
52	Endocytosis_Homo sapiens_hsa04144	0.76696148
53	Long-term depression_Homo sapiens_hsa04730	0.72679378
54	Caffeine metabolism_Homo sapiens_hsa00232	0.71468919
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71331437
56	Linoleic acid metabolism_Homo sapiens_hsa00591	0.71233834
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69793296
58	PPAR signaling pathway_Homo sapiens_hsa03320	0.69355015
59	Insulin secretion_Homo sapiens_hsa04911	0.69034216
60	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.68175707
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67536789
62	GABAergic synapse_Homo sapiens_hsa04727	0.67255853
63	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.66724428
64	Serotonergic synapse_Homo sapiens_hsa04726	0.65967661
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.64169229
66	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.63088275
67	Oocyte meiosis_Homo sapiens_hsa04114	0.62809978
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.61470836
69	Basal transcription factors_Homo sapiens_hsa03022	0.60623540
70	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.58551235
71	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.54182018
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50889876
73	Purine metabolism_Homo sapiens_hsa00230	0.50555278
74	Amphetamine addiction_Homo sapiens_hsa05031	0.50449092
75	Influenza A_Homo sapiens_hsa05164	0.49231572
76	Gastric acid secretion_Homo sapiens_hsa04971	0.48831971
77	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.46920821
78	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.46643205
79	Bile secretion_Homo sapiens_hsa04976	0.43954132
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43437733
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.43388237
82	MAPK signaling pathway_Homo sapiens_hsa04010	0.41536531
83	Estrogen signaling pathway_Homo sapiens_hsa04915	0.41397264
84	Renin-angiotensin system_Homo sapiens_hsa04614	0.41188715
85	ECM-receptor interaction_Homo sapiens_hsa04512	0.39991449
86	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.39262921
87	Cocaine addiction_Homo sapiens_hsa05030	0.38884141
88	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.38511629
89	Cholinergic synapse_Homo sapiens_hsa04725	0.38434617
90	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.37583689
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36051450
92	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.35638577
93	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.34461950
94	Sulfur relay system_Homo sapiens_hsa04122	0.33766258
95	Tight junction_Homo sapiens_hsa04530	0.33737287
96	Pancreatic secretion_Homo sapiens_hsa04972	0.33500287
97	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.30361887
98	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.29373264
99	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.28291425
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.23013141

SPATA31D3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »