ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	plasma membrane fusion (GO:0045026)	9.05812423
2	sperm capacitation (GO:0048240)	9.02001813
3	chromosome condensation (GO:0030261)	8.76030930
4	microtubule depolymerization (GO:0007019)	8.46382796
5	DNA packaging (GO:0006323)	8.41949039
6	response to pheromone (GO:0019236)	8.35769368
7	spermatid development (GO:0007286)	7.79025106
8	protein targeting to Golgi (GO:0000042)	7.64574973
9	single strand break repair (GO:0000012)	7.44944401
10	microtubule polymerization or depolymerization (GO:0031109)	7.44105474
11	establishment of protein localization to Golgi (GO:0072600)	7.37038290
12	sperm-egg recognition (GO:0035036)	7.27340100
13	retrograde transport, vesicle recycling within Golgi (GO:0000301)	7.12924060
14	protein polyglutamylation (GO:0018095)	7.06936885
15	multicellular organism reproduction (GO:0032504)	7.03940394
16	spermatid nucleus differentiation (GO:0007289)	6.96945455
17	rRNA methylation (GO:0031167)	6.74380790
18	centriole replication (GO:0007099)	6.71278579
19	calcium ion-dependent exocytosis (GO:0017156)	6.65652912
20	reproduction (GO:0000003)	6.44356335
21	binding of sperm to zona pellucida (GO:0007339)	6.41891422
22	spermatogenesis (GO:0007283)	6.29286944
23	male gamete generation (GO:0048232)	6.27178763
24	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.20563924
25	cell-cell recognition (GO:0009988)	6.00049050
26	axonemal dynein complex assembly (GO:0070286)	5.99807646
27	centriole assembly (GO:0098534)	5.79149803
28	negative regulation of inclusion body assembly (GO:0090084)	5.78041256
29	gamete generation (GO:0007276)	5.74399444
30	sexual reproduction (GO:0019953)	5.72952144
31	phosphatidylethanolamine metabolic process (GO:0046337)	5.71682070
32	microtubule severing (GO:0051013)	5.68331513
33	rRNA modification (GO:0000154)	5.64326473
34	regulation of Rab GTPase activity (GO:0032313)	5.57951896
35	positive regulation of Rab GTPase activity (GO:0032851)	5.57951896
36	regulation of centriole replication (GO:0046599)	5.55370930
37	protein localization to Golgi apparatus (GO:0034067)	5.48773062
38	seminiferous tubule development (GO:0072520)	5.31248786
39	single fertilization (GO:0007338)	5.10010082
40	regulation of transcription involved in cell fate commitment (GO:0060850)	5.05314491
41	cilium or flagellum-dependent cell motility (GO:0001539)	5.01449440
42	regulation of cilium movement (GO:0003352)	5.01344329
43	RNA destabilization (GO:0050779)	4.66947668
44	cellular ketone body metabolic process (GO:0046950)	4.66466243
45	motile cilium assembly (GO:0044458)	4.63277221
46	multicellular organismal reproductive process (GO:0048609)	4.58265374
47	germ cell development (GO:0007281)	4.43594416
48	cell wall macromolecule metabolic process (GO:0044036)	4.39214751
49	fertilization (GO:0009566)	4.37383377
50	cell wall macromolecule catabolic process (GO:0016998)	4.32858094
51	musculoskeletal movement (GO:0050881)	4.31048650
52	multicellular organismal movement (GO:0050879)	4.31048650
53	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.29195872
54	epithelial cilium movement (GO:0003351)	4.16593270
55	regulation of inclusion body assembly (GO:0090083)	4.15612739
56	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.12958211
57	ketone body metabolic process (GO:1902224)	4.10715903
58	chromatin silencing (GO:0006342)	4.00726443
59	glomerular visceral epithelial cell development (GO:0072015)	3.98566964
60	microtubule nucleation (GO:0007020)	3.92733715
61	nucleus organization (GO:0006997)	3.90563996
62	glycerol ether metabolic process (GO:0006662)	3.82933342
63	glomerular epithelial cell development (GO:0072310)	3.76853147
64	Golgi to endosome transport (GO:0006895)	3.76220417
65	cilium movement (GO:0003341)	3.67537203
66	organic cation transport (GO:0015695)	3.60265008
67	coenzyme catabolic process (GO:0009109)	3.60050607
68	ether metabolic process (GO:0018904)	3.52948257
69	membrane protein intracellular domain proteolysis (GO:0031293)	3.38689239
70	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.37234748
71	cerebral cortex neuron differentiation (GO:0021895)	3.35027170
72	response to acidic pH (GO:0010447)	3.34552935
73	negative regulation of Rho protein signal transduction (GO:0035024)	3.27439240
74	protein depolymerization (GO:0051261)	3.22032360
75	regulation of microtubule-based movement (GO:0060632)	3.20323772
76	cellular response to pH (GO:0071467)	3.19366814
77	peptidyl-threonine dephosphorylation (GO:0035970)	3.17050868
78	regulation of interleukin-13 production (GO:0032656)	3.04668479
79	histone H3-K9 demethylation (GO:0033169)	3.01567259
80	multicellular organismal development (GO:0007275)	2.97152282
81	homeostasis of number of cells within a tissue (GO:0048873)	2.96940884
82	regulation of T-helper 2 cell differentiation (GO:0045628)	2.92724737
83	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.91168537
84	polyamine biosynthetic process (GO:0006596)	2.90744975
85	positive regulation of guanylate cyclase activity (GO:0031284)	2.89789858
86	cell recognition (GO:0008037)	2.89150146
87	intra-Golgi vesicle-mediated transport (GO:0006891)	2.84936824
88	regulation of guanylate cyclase activity (GO:0031282)	2.84470391
89	mitotic G1 DNA damage checkpoint (GO:0031571)	2.83524444
90	centrosome duplication (GO:0051298)	2.78554643
91	piRNA metabolic process (GO:0034587)	2.76270575
92	vesicle transport along microtubule (GO:0047496)	2.74958528
93	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.74433471
94	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.74433471
95	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.73338607
96	protein-DNA complex disassembly (GO:0032986)	2.72993708
97	nucleosome disassembly (GO:0006337)	2.72993708
98	fusion of sperm to egg plasma membrane (GO:0007342)	11.9374928
99	sperm motility (GO:0030317)	11.7367335
100	acrosome reaction (GO:0007340)	11.5172521

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.25421334
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.97053573
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.60293736
4	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.52320708
5	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.52320708
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.47497945
7	CBP_20019798_ChIP-Seq_JUKART_Human	2.27553591
8	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.27553591
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.26300777
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21229600
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10326980
12	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.05679630
13	FUS_26573619_Chip-Seq_HEK293_Human	2.02710187
14	DROSHA_22980978_ChIP-Seq_HELA_Human	1.97645622
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.91180954
16	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.87186502
17	RAC3_21632823_ChIP-Seq_H3396_Human	1.86523233
18	ERA_21632823_ChIP-Seq_H3396_Human	1.83339406
19	NANOG_20526341_ChIP-Seq_ESCs_Human	1.74926435
20	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.73219873
21	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.71816401
22	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.70845968
23	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.70753665
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70620336
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69816999
26	MYC_19829295_ChIP-Seq_ESCs_Human	1.63471858
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.60968633
28	CTCF_27219007_Chip-Seq_Bcells_Human	1.60921957
29	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.57521844
30	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.56914924
31	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.56129204
32	TAF2_19829295_ChIP-Seq_ESCs_Human	1.54842438
33	BCL6_27268052_Chip-Seq_Bcells_Human	1.53292211
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49191554
35	SMC4_20622854_ChIP-Seq_HELA_Human	1.47688023
36	E2F1_20622854_ChIP-Seq_HELA_Human	1.46005723
37	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.45480228
38	OCT4_20526341_ChIP-Seq_ESCs_Human	1.44843897
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42991161
40	AR_25329375_ChIP-Seq_VCAP_Human	1.40567750
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.40254178
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40097096
43	TP53_18474530_ChIP-ChIP_U2OS_Human	1.39692549
44	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.38708131
45	CTCF_20526341_ChIP-Seq_ESCs_Human	1.38595176
46	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.38308997
47	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.38169483
48	BCOR_27268052_Chip-Seq_Bcells_Human	1.37316170
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.36315496
50	P68_20966046_ChIP-Seq_HELA_Human	1.36094848
51	PHF8_20622854_ChIP-Seq_HELA_Human	1.35765442
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.35435486
53	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.35332095
54	ERG_20517297_ChIP-Seq_VCAP_Human	1.35114443
55	RBPJ_21746931_ChIP-Seq_IB4_Human	1.34534081
56	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.34125199
57	TP63_22573176_ChIP-Seq_HFKS_Human	1.34066321
58	ETV1_20927104_ChIP-Seq_GIST48_Human	1.33091409
59	AR_21572438_ChIP-Seq_LNCaP_Human	1.32682950
60	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.31121226
61	ZNF274_21170338_ChIP-Seq_K562_Hela	1.30069782
62	P300_19829295_ChIP-Seq_ESCs_Human	1.28212442
63	NFYB_21822215_ChIP-Seq_K562_Human	1.26288408
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.24087236
65	CEBPB_22108803_ChIP-Seq_LS180_Human	1.23757332
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23653712
67	P300_27268052_Chip-Seq_Bcells_Human	1.22946427
68	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.22036162
69	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.21554779
70	TBL1_22424771_ChIP-Seq_293T_Human	1.20701437
71	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.20530582
72	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.16173804
73	P53_21459846_ChIP-Seq_SAOS-2_Human	1.16115483
74	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.15890942
75	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.15743471
76	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15369728
77	PHF8_20622853_ChIP-Seq_HELA_Human	1.15085769
78	LXR_22292898_ChIP-Seq_THP-1_Human	1.14687974
79	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.14506061
80	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.13660878
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12772202
82	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.11068341
83	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.10938663
84	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09950712
85	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.08773606
86	STAT3_23295773_ChIP-Seq_U87_Human	1.08316489
87	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08269829
88	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08269829
89	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07443431
90	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07320385
91	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06085347
92	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.05771418
93	SMRT_27268052_Chip-Seq_Bcells_Human	1.05432285
94	NFYA_21822215_ChIP-Seq_K562_Human	1.05364104
95	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.05202906
96	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03257736
97	KLF5_25053715_ChIP-Seq_YYC3_Human	1.01413964
98	SA1_27219007_Chip-Seq_Bcells_Human	1.00266763
99	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.99880657
100	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99459278

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	5.72419656
2	MP0005377_hearing/vestibular/ear_phenot	5.72419656
3	MP0005670_abnormal_white_adipose	4.63376554
4	MP0003698_abnormal_male_reproductive	4.30151707
5	MP0001929_abnormal_gametogenesis	3.75487499
6	MP0001348_abnormal_lacrimal_gland	3.53372954
7	MP0002161_abnormal_fertility/fecundity	2.36932579
8	MP0000678_abnormal_parathyroid_gland	2.34315777
9	MP0003718_maternal_effect	2.17882629
10	MP0003646_muscle_fatigue	2.10543677
11	MP0005410_abnormal_fertilization	11.7516500
12	MP0001485_abnormal_pinna_reflex	1.89919282
13	MP0005451_abnormal_body_composition	1.89886445
14	MP0005379_endocrine/exocrine_gland_phen	1.89015107
15	MP0002822_catalepsy	1.77355351
16	MP0002132_abnormal_respiratory_system	1.75758680
17	MP0001486_abnormal_startle_reflex	1.73933896
18	MP0003011_delayed_dark_adaptation	1.73491716
19	MP0002210_abnormal_sex_determination	1.70840971
20	MP0005423_abnormal_somatic_nervous	1.58576932
21	MP0005310_abnormal_salivary_gland	1.54819491
22	MP0003879_abnormal_hair_cell	1.39567983
23	MP0002282_abnormal_trachea_morphology	1.39374373
24	MP0004510_myositis	1.38180815
25	MP0002234_abnormal_pharynx_morphology	1.37358141
26	MP0001145_abnormal_male_reproductive	1.36542372
27	MP0004742_abnormal_vestibular_system	1.35994821
28	MP0004859_abnormal_synaptic_plasticity	1.35362480
29	MP0001968_abnormal_touch/_nociception	1.35210004
30	MP0002249_abnormal_larynx_morphology	1.32011458
31	MP0000653_abnormal_sex_gland	1.30215914
32	MP0009053_abnormal_anal_canal	1.29157037
33	MP0001765_abnormal_ion_homeostasis	1.21879289
34	MP0001963_abnormal_hearing_physiology	1.20209281
35	MP0002138_abnormal_hepatobiliary_system	1.15120893
36	MP0002735_abnormal_chemical_nociception	1.10196210
37	MP0000534_abnormal_ureter_morphology	1.05342945
38	MP0000026_abnormal_inner_ear	1.00655135
39	MP0005395_other_phenotype	0.99512766
40	MP0005248_abnormal_Harderian_gland	0.97944578
41	MP0005551_abnormal_eye_electrophysiolog	0.97179786
42	MP0002127_abnormal_cardiovascular_syste	0.94033050
43	MP0000955_abnormal_spinal_cord	0.86408732
44	MP0002733_abnormal_thermal_nociception	0.85703727
45	MP0002229_neurodegeneration	0.85681774
46	MP0009115_abnormal_fat_cell	0.85074584
47	MP0005167_abnormal_blood-brain_barrier	0.84823485
48	MP0002067_abnormal_sensory_capabilities	0.82384804
49	MP0008877_abnormal_DNA_methylation	0.80305324
50	MP0001905_abnormal_dopamine_level	0.78783438
51	MP0005666_abnormal_adipose_tissue	0.77042843
52	MP0008569_lethality_at_weaning	0.76949277
53	MP0000681_abnormal_thyroid_gland	0.74251597
54	MP0005253_abnormal_eye_physiology	0.73749149
55	MP0004085_abnormal_heartbeat	0.73255622
56	MP0009697_abnormal_copulation	0.69079858
57	MP0002572_abnormal_emotion/affect_behav	0.67807949
58	MP0005083_abnormal_biliary_tract	0.67087558
59	MP0002557_abnormal_social/conspecific_i	0.66992654
60	MP0000049_abnormal_middle_ear	0.65196158
61	MP0005375_adipose_tissue_phenotype	0.63672949
62	MP0005636_abnormal_mineral_homeostasis	0.63492630
63	MP0001440_abnormal_grooming_behavior	0.63261212
64	MP0009745_abnormal_behavioral_response	0.61757771
65	MP0000516_abnormal_urinary_system	0.58930837
66	MP0005367_renal/urinary_system_phenotyp	0.58930837
67	MP0008995_early_reproductive_senescence	0.57638352
68	MP0001970_abnormal_pain_threshold	0.55429297
69	MP0002272_abnormal_nervous_system	0.54860201
70	MP0000003_abnormal_adipose_tissue	0.54246871
71	MP0009764_decreased_sensitivity_to	0.53815008
72	MP0004233_abnormal_muscle_weight	0.53615501
73	MP0001666_abnormal_nutrient_absorption	0.53481599
74	MP0002734_abnormal_mechanical_nocicepti	0.53306228
75	MP0004484_altered_response_of	0.52647692
76	MP0005397_hematopoietic_system_phenotyp	0.51135186
77	MP0001545_abnormal_hematopoietic_system	0.51135186
78	MP0000230_abnormal_systemic_arterial	0.50121908
79	MP0001984_abnormal_olfaction	0.50093268
80	MP0001501_abnormal_sleep_pattern	0.49489904
81	MP0001879_abnormal_lymphatic_vessel	0.49446000
82	MP0005535_abnormal_body_temperature	0.46979453
83	MP0003137_abnormal_impulse_conducting	0.46461033
84	MP0003880_abnormal_central_pattern	0.46377521
85	MP0003631_nervous_system_phenotype	0.44013483
86	MP0004036_abnormal_muscle_relaxation	0.43914469
87	MP0003077_abnormal_cell_cycle	0.43385822
88	MP0003635_abnormal_synaptic_transmissio	0.41755919
89	MP0009278_abnormal_bone_marrow	0.40642689
90	MP0005623_abnormal_meninges_morphology	0.40367775
91	MP0008961_abnormal_basal_metabolism	0.40055861
92	MP0004084_abnormal_cardiac_muscle	0.39723381
93	MP0003633_abnormal_nervous_system	0.38963825
94	MP0000470_abnormal_stomach_morphology	0.37505049
95	MP0003119_abnormal_digestive_system	0.36486778
96	MP0000249_abnormal_blood_vessel	0.36362182
97	MP0002928_abnormal_bile_duct	0.35557137
98	MP0005391_vision/eye_phenotype	0.35421724
99	MP0004782_abnormal_surfactant_physiolog	0.34061659
100	MP0003936_abnormal_reproductive_system	0.33349227

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.93851480
2	Asymmetric septal hypertrophy (HP:0001670)	6.19710640
3	Absent/shortened dynein arms (HP:0200106)	5.78589441
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.78589441
5	Tubulointerstitial nephritis (HP:0001970)	5.34040972
6	Chronic hepatic failure (HP:0100626)	5.05532372
7	Attenuation of retinal blood vessels (HP:0007843)	4.88220287
8	Bony spicule pigmentary retinopathy (HP:0007737)	4.88111222
9	Bell-shaped thorax (HP:0001591)	4.63194210
10	Resting tremor (HP:0002322)	4.55601525
11	Male infertility (HP:0003251)	4.49821536
12	Abnormal ciliary motility (HP:0012262)	4.40289850
13	Abnormal respiratory motile cilium physiology (HP:0012261)	4.40147351
14	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.36332721
15	Hypoplastic ischia (HP:0003175)	4.29251530
16	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.13004152
17	Hyperkalemia (HP:0002153)	4.12208053
18	Abnormal respiratory motile cilium morphology (HP:0005938)	4.07364467
19	Abnormal respiratory epithelium morphology (HP:0012253)	4.07364467
20	Abnormality of macular pigmentation (HP:0008002)	4.06229945
21	Cone-rod dystrophy (HP:0000548)	4.05403811
22	Enlarged epiphyses (HP:0010580)	3.99340926
23	Infertility (HP:0000789)	3.99083110
24	Nasal polyposis (HP:0100582)	3.87856276
25	Abnormality of the ischium (HP:0003174)	3.83701827
26	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.82344575
27	Facial shape deformation (HP:0011334)	3.75488776
28	Potter facies (HP:0002009)	3.75488776
29	Impulsivity (HP:0100710)	3.68470462
30	Abnormal rod and cone electroretinograms (HP:0008323)	3.60376132
31	Hypoplasia of the thymus (HP:0000778)	3.45461506
32	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.24820382
33	Abnormality of the nasal mucosa (HP:0000433)	3.14935288
34	Abnormal spermatogenesis (HP:0008669)	3.14470615
35	Hypoalphalipoproteinemia (HP:0003233)	3.14079400
36	Postural instability (HP:0002172)	3.13981188
37	Amelogenesis imperfecta (HP:0000705)	3.06610256
38	Progressive sensorineural hearing impairment (HP:0000408)	3.02992806
39	Nephronophthisis (HP:0000090)	3.00594889
40	Abnormality of dental color (HP:0011073)	2.94100775
41	Progressive cerebellar ataxia (HP:0002073)	2.82644457
42	Azoospermia (HP:0000027)	2.81797179
43	Portal hypertension (HP:0001409)	2.79455019
44	Stage 5 chronic kidney disease (HP:0003774)	2.77945834
45	Abnormal urine output (HP:0012590)	2.74018235
46	Truncal obesity (HP:0001956)	2.73599386
47	Menstrual irregularities (HP:0000858)	2.72322889
48	Renovascular hypertension (HP:0100817)	2.66968381
49	Tubulointerstitial abnormality (HP:0001969)	2.66929229
50	Rhinitis (HP:0012384)	2.65280233
51	Abnormality of the costochondral junction (HP:0000919)	2.62046674
52	Abnormality of the hepatic vasculature (HP:0006707)	2.56420679
53	Insulin-resistant diabetes mellitus (HP:0000831)	2.55244952
54	Abnormality of the renal medulla (HP:0100957)	2.55123206
55	Generalized aminoaciduria (HP:0002909)	2.55061382
56	Abnormality of the aortic arch (HP:0012303)	2.51613018
57	Epiphyseal dysplasia (HP:0002656)	2.50727176
58	Abnormal drinking behavior (HP:0030082)	2.43405138
59	Polydipsia (HP:0001959)	2.43405138
60	Abnormality of potassium homeostasis (HP:0011042)	2.38981830
61	Abnormality of renal excretion (HP:0011036)	2.37099100
62	Unilateral renal agenesis (HP:0000122)	2.30824093
63	Ventricular tachycardia (HP:0004756)	2.29837980
64	Intellectual disability, moderate (HP:0002342)	2.27913723
65	Hypophosphatemic rickets (HP:0004912)	2.24315534
66	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.18834726
67	Absent epiphyses (HP:0010577)	2.18834726
68	Congenital malformation of the right heart (HP:0011723)	2.18691009
69	Double outlet right ventricle (HP:0001719)	2.18691009
70	Polyuria (HP:0000103)	2.18058702
71	Osteomalacia (HP:0002749)	2.16896088
72	Chronic bronchitis (HP:0004469)	2.14274430
73	Renal dysplasia (HP:0000110)	2.12933196
74	Recurrent pneumonia (HP:0006532)	2.08477013
75	Flattened epiphyses (HP:0003071)	2.07683399
76	Abnormality of the pubic bones (HP:0003172)	2.05823455
77	Focal segmental glomerulosclerosis (HP:0000097)	2.05681246
78	Hyperuricemia (HP:0002149)	2.05674111
79	Increased purine levels (HP:0004368)	2.05674111
80	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.04200294
81	Widely patent fontanelles and sutures (HP:0004492)	2.02935144
82	Progressive hearing impairment (HP:0001730)	1.95780806
83	Bronchiectasis (HP:0002110)	1.91915559
84	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.91681536
85	Abnormality of femoral epiphyses (HP:0006499)	1.91681536
86	Tubular atrophy (HP:0000092)	1.91471340
87	Optic nerve hypoplasia (HP:0000609)	1.86675421
88	Hyponatremia (HP:0002902)	1.86663854
89	Decreased central vision (HP:0007663)	1.86620777
90	Bradycardia (HP:0001662)	1.82158023
91	Abnormality of the femoral head (HP:0003368)	1.81390791
92	Recurrent corneal erosions (HP:0000495)	1.81186715
93	Abnormality of the parathyroid morphology (HP:0011766)	1.80429983
94	Protuberant abdomen (HP:0001538)	1.78702455
95	Congenital sensorineural hearing impairment (HP:0008527)	1.77660975
96	Myokymia (HP:0002411)	1.77479069
97	Mixed hearing impairment (HP:0000410)	1.75963942
98	Short ribs (HP:0000773)	1.75764650
99	Renal Fanconi syndrome (HP:0001994)	1.75478675
100	Sandal gap (HP:0001852)	1.74087655

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	9.45529490
2	TESK1	5.25980794
3	DDR2	5.06274300
4	INSRR	4.56104260
5	PLK2	3.58479662
6	BRD4	3.36345012
7	PNCK	3.03449845
8	MAP4K2	2.70543610
9	STK38	2.64910828
10	CAMK1G	2.38822466
11	PIK3CG	2.18749082
12	STK38L	2.15745758
13	MAPK15	2.08504284
14	PRKD3	1.95961636
15	MST1R	1.73670344
16	PDPK1	1.44927516
17	PDK1	1.42308842
18	WNK1	1.41618087
19	CDK12	1.28012809
20	TYRO3	1.23773266
21	CDK7	1.23378032
22	PTK2B	1.23092834
23	NEK6	1.17422813
24	DYRK1B	1.10892262
25	CAMK1D	0.92912229
26	KSR2	0.83880320
27	PRKG2	0.80530352
28	AKT3	0.80348644
29	MAP3K11	0.76319107
30	RPS6KA2	0.68702051
31	MAP3K9	0.67125193
32	SIK2	0.66596989
33	BRAF	0.63581606
34	PRKG1	0.62938553
35	PRKAA2	0.59122198
36	UHMK1	0.57789588
37	ADRBK2	0.55214904
38	CAMK1	0.53803502
39	TIE1	0.53734474
40	LATS2	0.53725151
41	RPS6KA1	0.52209119
42	MAP2K2	0.50012686
43	CDK3	0.48391983
44	MAP3K2	0.47447054
45	ROCK1	0.47252530
46	PRKCG	0.43450144
47	JAK3	0.42173776
48	FRK	0.41275028
49	CDK2	0.40168661
50	MAPK1	0.38774337
51	GSK3B	0.38359414
52	MUSK	0.38152674
53	MARK1	0.37861458
54	STK39	0.37657220
55	RPS6KL1	0.36599711
56	RPS6KC1	0.36599711
57	MAP3K8	0.35900915
58	RPS6KA6	0.35667657
59	CDK1	0.35359996
60	SGK223	0.34947078
61	SGK494	0.34947078
62	BRSK1	0.33567319
63	LATS1	0.33318097
64	CAMK4	0.33116718
65	BMPR1B	0.32679693
66	WNK4	0.32210027
67	NTRK3	0.30806554
68	MAP3K4	0.30013625
69	MAPK8	0.27882747
70	MAPK11	0.27543909
71	MTOR	0.26898782
72	PRKCZ	0.26856929
73	PRKCB	0.25792309
74	CDK4	0.24885925
75	OXSR1	0.24095835
76	TESK2	0.23431574
77	MAP3K1	0.23368260
78	SGK1	0.22689364
79	MET	0.22047205
80	CHEK1	0.21709489
81	MARK2	0.20403255
82	MAPK14	0.18940889
83	ARAF	0.18226858
84	PINK1	0.17818560
85	MAPK10	0.16869732
86	AKT1	0.15360794
87	PRKCE	0.14817465
88	PKN1	0.14468290
89	BLK	0.13287253
90	SGK2	0.13279056
91	RIPK4	0.12912118
92	DYRK3	0.11425290
93	BRSK2	0.10976244
94	TNIK	0.08989383
95	CAMK2A	0.08762131
96	CHUK	0.08719367
97	PRKACB	0.08419977
98	RIPK1	0.08397115
99	PRKACA	0.08002345
100	PRKAA1	0.06716453

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	6.64793952
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	6.12160169
3	Olfactory transduction_Homo sapiens_hsa04740	4.20189024
4	Butanoate metabolism_Homo sapiens_hsa00650	2.26266634
5	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.24181624
6	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.07822918
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.05790475
8	Taste transduction_Homo sapiens_hsa04742	1.91867839
9	Phenylalanine metabolism_Homo sapiens_hsa00360	1.68316245
10	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.61958204
11	Type I diabetes mellitus_Homo sapiens_hsa04940	1.60981351
12	RNA transport_Homo sapiens_hsa03013	1.59736020
13	Type II diabetes mellitus_Homo sapiens_hsa04930	1.59647499
14	Fatty acid degradation_Homo sapiens_hsa00071	1.58767723
15	Allograft rejection_Homo sapiens_hsa05330	1.54697609
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.51983159
17	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.44500613
18	Graft-versus-host disease_Homo sapiens_hsa05332	1.43141629
19	Protein digestion and absorption_Homo sapiens_hsa04974	1.34345705
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.29810436
21	Fatty acid metabolism_Homo sapiens_hsa01212	1.27985130
22	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.22128128
23	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.20851471
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19675746
25	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.18380098
26	Phototransduction_Homo sapiens_hsa04744	1.17346712
27	ABC transporters_Homo sapiens_hsa02010	1.15983758
28	Salivary secretion_Homo sapiens_hsa04970	1.12673390
29	Viral myocarditis_Homo sapiens_hsa05416	1.10659652
30	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.10390166
31	Morphine addiction_Homo sapiens_hsa05032	1.04474669
32	Nicotine addiction_Homo sapiens_hsa05033	1.03073552
33	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.01277418
34	Arginine biosynthesis_Homo sapiens_hsa00220	1.01113085
35	Calcium signaling pathway_Homo sapiens_hsa04020	1.00884917
36	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.99060898
37	Arginine and proline metabolism_Homo sapiens_hsa00330	0.98174324
38	Selenocompound metabolism_Homo sapiens_hsa00450	0.96170284
39	Endocytosis_Homo sapiens_hsa04144	0.95480029
40	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.93940579
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.91916349
42	cAMP signaling pathway_Homo sapiens_hsa04024	0.88855775
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.87693209
44	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.85760623
45	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.85502456
46	PPAR signaling pathway_Homo sapiens_hsa03320	0.82844408
47	Circadian entrainment_Homo sapiens_hsa04713	0.82743203
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.82602341
49	Influenza A_Homo sapiens_hsa05164	0.78412774
50	Oocyte meiosis_Homo sapiens_hsa04114	0.77418859
51	Glycerolipid metabolism_Homo sapiens_hsa00561	0.76813616
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.76034574
53	Renin-angiotensin system_Homo sapiens_hsa04614	0.75320824
54	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.74614025
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.73369506
56	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.72570317
57	Gastric acid secretion_Homo sapiens_hsa04971	0.68755940
58	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.68425665
59	Tyrosine metabolism_Homo sapiens_hsa00350	0.68235677
60	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67026979
61	Estrogen signaling pathway_Homo sapiens_hsa04915	0.66652285
62	VEGF signaling pathway_Homo sapiens_hsa04370	0.65098709
63	Renin secretion_Homo sapiens_hsa04924	0.64923681
64	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.64253972
65	Retinol metabolism_Homo sapiens_hsa00830	0.64241709
66	Bile secretion_Homo sapiens_hsa04976	0.62450410
67	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.61286253
68	Serotonergic synapse_Homo sapiens_hsa04726	0.57401579
69	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.56106638
70	Cholinergic synapse_Homo sapiens_hsa04725	0.52232654
71	Pancreatic secretion_Homo sapiens_hsa04972	0.51310759
72	Insulin secretion_Homo sapiens_hsa04911	0.50462636
73	MAPK signaling pathway_Homo sapiens_hsa04010	0.47527198
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.47104086
75	ECM-receptor interaction_Homo sapiens_hsa04512	0.47047245
76	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.41976308
77	Nitrogen metabolism_Homo sapiens_hsa00910	0.41238905
78	Purine metabolism_Homo sapiens_hsa00230	0.41175395
79	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38940436
80	Long-term potentiation_Homo sapiens_hsa04720	0.38677418
81	Tight junction_Homo sapiens_hsa04530	0.38228504
82	GABAergic synapse_Homo sapiens_hsa04727	0.37953748
83	Fanconi anemia pathway_Homo sapiens_hsa03460	0.36605529
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32431435
85	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.32307406
86	Acute myeloid leukemia_Homo sapiens_hsa05221	0.31693158
87	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.31390798
88	mRNA surveillance pathway_Homo sapiens_hsa03015	0.29698003
89	Prolactin signaling pathway_Homo sapiens_hsa04917	0.29209277
90	Amphetamine addiction_Homo sapiens_hsa05031	0.27646897
91	Basal transcription factors_Homo sapiens_hsa03022	0.25184352
92	Huntingtons disease_Homo sapiens_hsa05016	0.23351794
93	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.21453112
94	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.20252134
95	Linoleic acid metabolism_Homo sapiens_hsa00591	0.17385846
96	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.17197659
97	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.15413500
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.15351769
99	Long-term depression_Homo sapiens_hsa04730	0.13177083
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.12624574

SPATA31D5P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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