ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm capacitation (GO:0048240)	9.40535192
2	chromosome condensation (GO:0030261)	9.17454109
3	DNA packaging (GO:0006323)	8.86700619
4	response to pheromone (GO:0019236)	8.63887000
5	plasma membrane fusion (GO:0045026)	8.62607960
6	microtubule depolymerization (GO:0007019)	8.46039286
7	spermatid nucleus differentiation (GO:0007289)	8.29639798
8	spermatid development (GO:0007286)	8.27891821
9	single strand break repair (GO:0000012)	8.09624951
10	sperm-egg recognition (GO:0035036)	7.57841840
11	multicellular organism reproduction (GO:0032504)	7.24970337
12	protein polyglutamylation (GO:0018095)	7.18488830
13	negative regulation of inclusion body assembly (GO:0090084)	6.95531899
14	sexual reproduction (GO:0019953)	6.90797174
15	microtubule polymerization or depolymerization (GO:0031109)	6.90725965
16	reproduction (GO:0000003)	6.90418491
17	rRNA methylation (GO:0031167)	6.88654976
18	binding of sperm to zona pellucida (GO:0007339)	6.88271986
19	calcium ion-dependent exocytosis (GO:0017156)	6.67900426
20	protein targeting to Golgi (GO:0000042)	6.66353688
21	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.40538277
22	establishment of protein localization to Golgi (GO:0072600)	6.37672216
23	cell-cell recognition (GO:0009988)	6.22576094
24	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.20102291
25	axonemal dynein complex assembly (GO:0070286)	6.15375416
26	microtubule severing (GO:0051013)	6.12967456
27	* spermatogenesis (GO:0007283)	6.04141962
28	* male gamete generation (GO:0048232)	6.02047726
29	phosphatidylethanolamine metabolic process (GO:0046337)	5.90685268
30	rRNA modification (GO:0000154)	5.78877066
31	cellular ketone body metabolic process (GO:0046950)	5.73051406
32	* gamete generation (GO:0007276)	5.50082020
33	centriole replication (GO:0007099)	5.49709051
34	regulation of cilium movement (GO:0003352)	5.44955705
35	regulation of Rab GTPase activity (GO:0032313)	5.19682277
36	positive regulation of Rab GTPase activity (GO:0032851)	5.19682277
37	ketone body metabolic process (GO:1902224)	5.03780210
38	regulation of inclusion body assembly (GO:0090083)	5.01849319
39	single fertilization (GO:0007338)	4.99881385
40	RNA destabilization (GO:0050779)	4.94449611
41	motile cilium assembly (GO:0044458)	4.88429604
42	centriole assembly (GO:0098534)	4.87048489
43	protein localization to Golgi apparatus (GO:0034067)	4.82489430
44	cell wall macromolecule catabolic process (GO:0016998)	4.78307150
45	cilium or flagellum-dependent cell motility (GO:0001539)	4.67670431
46	germ cell development (GO:0007281)	4.60902958
47	regulation of transcription involved in cell fate commitment (GO:0060850)	4.60476901
48	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.55398024
49	cell wall macromolecule metabolic process (GO:0044036)	4.50757846
50	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.41741775
51	chromatin silencing (GO:0006342)	4.40733179
52	* multicellular organismal reproductive process (GO:0048609)	4.40617454
53	regulation of centriole replication (GO:0046599)	4.24134615
54	seminiferous tubule development (GO:0072520)	4.22694729
55	epithelial cilium movement (GO:0003351)	4.16454012
56	fertilization (GO:0009566)	4.16334115
57	nucleus organization (GO:0006997)	4.15920658
58	musculoskeletal movement (GO:0050881)	3.78348195
59	multicellular organismal movement (GO:0050879)	3.78348195
60	regulation of microtubule-based movement (GO:0060632)	3.75036454
61	organic cation transport (GO:0015695)	3.69192144
62	membrane protein intracellular domain proteolysis (GO:0031293)	3.68840104
63	polyamine biosynthetic process (GO:0006596)	3.66899805
64	glycerol ether metabolic process (GO:0006662)	3.66536876
65	response to acidic pH (GO:0010447)	3.65353971
66	cilium movement (GO:0003341)	3.62816466
67	coenzyme catabolic process (GO:0009109)	3.50387802
68	negative regulation of Rho protein signal transduction (GO:0035024)	3.46175554
69	regulation of T-helper 2 cell differentiation (GO:0045628)	3.45893232
70	glomerular visceral epithelial cell development (GO:0072015)	3.45569504
71	ether metabolic process (GO:0018904)	3.37336916
72	cellular response to pH (GO:0071467)	3.36874855
73	peptidyl-threonine dephosphorylation (GO:0035970)	3.35025972
74	glomerular epithelial cell development (GO:0072310)	3.32030472
75	cerebral cortex neuron differentiation (GO:0021895)	3.25923811
76	homeostasis of number of cells within a tissue (GO:0048873)	3.15101483
77	NAD biosynthetic process (GO:0009435)	3.13876597
78	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.08413772
79	protein depolymerization (GO:0051261)	3.07029721
80	protein-DNA complex disassembly (GO:0032986)	3.05325240
81	nucleosome disassembly (GO:0006337)	3.05325240
82	multicellular organismal development (GO:0007275)	3.04313487
83	regulation of interleukin-13 production (GO:0032656)	3.01102339
84	histone H3-K9 demethylation (GO:0033169)	2.98736611
85	negative regulation of gene expression, epigenetic (GO:0045814)	2.96632643
86	cell recognition (GO:0008037)	2.92600740
87	microtubule nucleation (GO:0007020)	2.92045701
88	male meiosis I (GO:0007141)	2.84688401
89	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.80035907
90	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.80035907
91	cell differentiation involved in metanephros development (GO:0072202)	2.70449675
92	DNA conformation change (GO:0071103)	2.68975430
93	positive regulation of type 2 immune response (GO:0002830)	2.66985389
94	positive regulation of guanylate cyclase activity (GO:0031284)	2.66592949
95	Golgi to endosome transport (GO:0006895)	2.64079671
96	cranial nerve morphogenesis (GO:0021602)	2.62710286
97	mitochondrial fission (GO:0000266)	2.62267165
98	acrosome reaction (GO:0007340)	12.2877977
99	sperm motility (GO:0030317)	12.1195834
100	fusion of sperm to egg plasma membrane (GO:0007342)	11.4285193

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.88607832
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.73180511
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.71507096
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.46103564
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.46103564
6	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.16889053
7	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.15790921
8	CBP_20019798_ChIP-Seq_JUKART_Human	2.15790921
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.15235674
10	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.14619593
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.06977041
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.05843453
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.94042735
14	RAC3_21632823_ChIP-Seq_H3396_Human	1.89169171
15	DROSHA_22980978_ChIP-Seq_HELA_Human	1.85836984
16	ERA_21632823_ChIP-Seq_H3396_Human	1.85128596
17	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.82101901
18	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.80858310
19	NANOG_20526341_ChIP-Seq_ESCs_Human	1.80428898
20	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.79905227
21	CTCF_27219007_Chip-Seq_Bcells_Human	1.76481747
22	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.75130015
23	FUS_26573619_Chip-Seq_HEK293_Human	1.72003253
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71673179
25	BCL6_27268052_Chip-Seq_Bcells_Human	1.71515400
26	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.65611787
27	TAF2_19829295_ChIP-Seq_ESCs_Human	1.63302965
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61049563
29	MYC_19829295_ChIP-Seq_ESCs_Human	1.60089990
30	E2F1_20622854_ChIP-Seq_HELA_Human	1.59613232
31	BCOR_27268052_Chip-Seq_Bcells_Human	1.58182060
32	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.57964769
33	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.57082328
34	SMC4_20622854_ChIP-Seq_HELA_Human	1.56241805
35	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.54504856
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51540745
37	CTCF_20526341_ChIP-Seq_ESCs_Human	1.49919095
38	PHF8_20622854_ChIP-Seq_HELA_Human	1.49890836
39	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.49454481
40	P68_20966046_ChIP-Seq_HELA_Human	1.47598993
41	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.47328318
42	OCT4_20526341_ChIP-Seq_ESCs_Human	1.46572639
43	LXR_22292898_ChIP-Seq_THP-1_Human	1.46386720
44	TP63_22573176_ChIP-Seq_HFKS_Human	1.45908934
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.41469569
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.41457840
47	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.40280077
48	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.38922098
49	AR_25329375_ChIP-Seq_VCAP_Human	1.38374330
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.38224140
51	P300_27268052_Chip-Seq_Bcells_Human	1.36699087
52	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36600648
53	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.35661476
54	ERG_20517297_ChIP-Seq_VCAP_Human	1.34196278
55	RBPJ_21746931_ChIP-Seq_IB4_Human	1.32616905
56	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.32529718
57	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.32424107
58	TP53_18474530_ChIP-ChIP_U2OS_Human	1.31929154
59	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.31358597
60	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.28751385
61	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.28490619
62	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.28148200
63	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.27883445
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26744574
65	ETV1_20927104_ChIP-Seq_GIST48_Human	1.25321362
66	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.24454824
67	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.24195139
68	CEBPB_22108803_ChIP-Seq_LS180_Human	1.23920354
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20789273
70	SA1_27219007_Chip-Seq_Bcells_Human	1.16152859
71	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.15618407
72	NFYB_21822215_ChIP-Seq_K562_Human	1.15472049
73	P53_21459846_ChIP-Seq_SAOS-2_Human	1.14925655
74	TAF15_26573619_Chip-Seq_HEK293_Human	1.14347091
75	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13796347
76	RUNX_20019798_ChIP-Seq_JUKART_Human	1.12853996
77	SMRT_27268052_Chip-Seq_Bcells_Human	1.09302849
78	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.09106671
79	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.09014842
80	P300_19829295_ChIP-Seq_ESCs_Human	1.08834330
81	TBL1_22424771_ChIP-Seq_293T_Human	1.08681433
82	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.08591703
83	PHF8_20622853_ChIP-Seq_HELA_Human	1.07888601
84	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.07847226
85	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.07495711
86	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06336159
87	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.05532312
88	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05161712
89	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.03856474
90	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02357761
91	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02357761
92	VDR_24787735_ChIP-Seq_THP-1_Human	1.01583671
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01109736
94	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.00904461
95	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.00429598
96	NFYA_21822215_ChIP-Seq_K562_Human	1.00359400
97	ZNF274_21170338_ChIP-Seq_K562_Hela	0.99698157
98	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97817759
99	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.97668264
100	KLF5_25053715_ChIP-Seq_YYC3_Human	0.97649748

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	5.79088945
2	MP0003878_abnormal_ear_physiology	5.79088945
3	MP0005670_abnormal_white_adipose	4.51050078
4	MP0003698_abnormal_male_reproductive	4.38269944
5	MP0001929_abnormal_gametogenesis	3.77980031
6	MP0001348_abnormal_lacrimal_gland	3.10426308
7	MP0002161_abnormal_fertility/fecundity	2.46289537
8	MP0003646_muscle_fatigue	2.27395251
9	MP0000678_abnormal_parathyroid_gland	2.20823925
10	MP0004510_myositis	2.13003686
11	MP0005410_abnormal_fertilization	12.3567359
12	MP0003718_maternal_effect	1.96522039
13	MP0003011_delayed_dark_adaptation	1.95159534
14	MP0001485_abnormal_pinna_reflex	1.74607459
15	MP0002210_abnormal_sex_determination	1.68764156
16	MP0002132_abnormal_respiratory_system	1.64077985
17	MP0005379_endocrine/exocrine_gland_phen	1.63729965
18	MP0005310_abnormal_salivary_gland	1.61348254
19	MP0005451_abnormal_body_composition	1.47186896
20	MP0001486_abnormal_startle_reflex	1.40537962
21	MP0002282_abnormal_trachea_morphology	1.39715919
22	MP0001145_abnormal_male_reproductive	1.35407335
23	MP0002234_abnormal_pharynx_morphology	1.34937378
24	MP0000653_abnormal_sex_gland	1.30121156
25	MP0002138_abnormal_hepatobiliary_system	1.26327013
26	MP0005423_abnormal_somatic_nervous	1.26277910
27	MP0003879_abnormal_hair_cell	1.26074250
28	MP0002822_catalepsy	1.20373632
29	MP0001765_abnormal_ion_homeostasis	1.19959407
30	MP0002249_abnormal_larynx_morphology	1.16587184
31	MP0002735_abnormal_chemical_nociception	1.15081477
32	MP0004742_abnormal_vestibular_system	1.13247618
33	MP0001963_abnormal_hearing_physiology	1.10075904
34	MP0009053_abnormal_anal_canal	1.09947911
35	MP0004859_abnormal_synaptic_plasticity	1.04672244
36	MP0005248_abnormal_Harderian_gland	1.03339255
37	MP0005666_abnormal_adipose_tissue	1.03077372
38	MP0000026_abnormal_inner_ear	1.00746434
39	MP0005167_abnormal_blood-brain_barrier	0.96346285
40	MP0000534_abnormal_ureter_morphology	0.94418406
41	MP0001968_abnormal_touch/_nociception	0.91255019
42	MP0009115_abnormal_fat_cell	0.90313960
43	MP0002229_neurodegeneration	0.87817776
44	MP0005395_other_phenotype	0.85622494
45	MP0009764_decreased_sensitivity_to	0.82930446
46	MP0003303_peritoneal_inflammation	0.80991120
47	MP0002127_abnormal_cardiovascular_syste	0.79765608
48	MP0005636_abnormal_mineral_homeostasis	0.76639950
49	MP0000955_abnormal_spinal_cord	0.74466261
50	MP0005375_adipose_tissue_phenotype	0.73312128
51	MP0008569_lethality_at_weaning	0.71599626
52	MP0002067_abnormal_sensory_capabilities	0.69430971
53	MP0005551_abnormal_eye_electrophysiolog	0.69182856
54	MP0002254_reproductive_system_inflammat	0.67282780
55	MP0002733_abnormal_thermal_nociception	0.65592270
56	MP0005253_abnormal_eye_physiology	0.64529464
57	MP0005535_abnormal_body_temperature	0.64203209
58	MP0001501_abnormal_sleep_pattern	0.63421501
59	MP0000681_abnormal_thyroid_gland	0.61647605
60	MP0005083_abnormal_biliary_tract	0.60518315
61	MP0008877_abnormal_DNA_methylation	0.59702321
62	MP0002653_abnormal_ependyma_morphology	0.59489071
63	MP0000049_abnormal_middle_ear	0.58147425
64	MP0002557_abnormal_social/conspecific_i	0.58073795
65	MP0004085_abnormal_heartbeat	0.57765604
66	MP0001905_abnormal_dopamine_level	0.57467103
67	MP0001879_abnormal_lymphatic_vessel	0.56352632
68	MP0003137_abnormal_impulse_conducting	0.56117327
69	MP0009785_altered_susceptibility_to	0.54540479
70	MP0009697_abnormal_copulation	0.53388700
71	MP0002572_abnormal_emotion/affect_behav	0.50952517
72	MP0005397_hematopoietic_system_phenotyp	0.47758234
73	MP0001545_abnormal_hematopoietic_system	0.47758234
74	MP0001970_abnormal_pain_threshold	0.47412827
75	MP0003091_abnormal_cell_migration	0.46207681
76	MP0000249_abnormal_blood_vessel	0.45853106
77	MP0009278_abnormal_bone_marrow	0.45782279
78	MP0000516_abnormal_urinary_system	0.44508954
79	MP0005367_renal/urinary_system_phenotyp	0.44508954
80	MP0008961_abnormal_basal_metabolism	0.43781514
81	MP0003172_abnormal_lysosome_physiology	0.43213444
82	MP0009745_abnormal_behavioral_response	0.43023559
83	MP0000230_abnormal_systemic_arterial	0.43004856
84	MP0001666_abnormal_nutrient_absorption	0.42154480
85	MP0005647_abnormal_sex_gland	0.40899710
86	MP0005166_decreased_susceptibility_to	0.40775701
87	MP0005595_abnormal_vascular_smooth	0.39810699
88	MP0001533_abnormal_skeleton_physiology	0.39560598
89	MP0001440_abnormal_grooming_behavior	0.39418143
90	MP0002272_abnormal_nervous_system	0.37421415
91	MP0003699_abnormal_female_reproductive	0.37007896
92	MP0005084_abnormal_gallbladder_morpholo	0.36956799
93	MP0003631_nervous_system_phenotype	0.36445843
94	MP0002332_abnormal_exercise_endurance	0.36225078
95	MP0000470_abnormal_stomach_morphology	0.35052993
96	MP0008874_decreased_physiological_sensi	0.34456447
97	MP0003632_abnormal_nervous_system	0.33885305
98	MP0005391_vision/eye_phenotype	0.33600631
99	MP0000003_abnormal_adipose_tissue	0.32136835
100	MP0004484_altered_response_of	0.31899269

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.61165336
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.15055156
3	Absent/shortened dynein arms (HP:0200106)	6.15055156
4	Asymmetric septal hypertrophy (HP:0001670)	5.57689286
5	Bony spicule pigmentary retinopathy (HP:0007737)	5.07434974
6	Attenuation of retinal blood vessels (HP:0007843)	5.00286874
7	Tubulointerstitial nephritis (HP:0001970)	4.99865919
8	Chronic hepatic failure (HP:0100626)	4.85055620
9	Abnormal ciliary motility (HP:0012262)	4.65202581
10	Abnormal respiratory epithelium morphology (HP:0012253)	4.48356777
11	Abnormal respiratory motile cilium morphology (HP:0005938)	4.48356777
12	Abnormal respiratory motile cilium physiology (HP:0012261)	4.47900580
13	Bell-shaped thorax (HP:0001591)	4.39301790
14	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.38044585
15	Nasal polyposis (HP:0100582)	4.37259287
16	Hyperkalemia (HP:0002153)	4.23360482
17	Male infertility (HP:0003251)	4.23225701
18	Infertility (HP:0000789)	4.20955552
19	Enlarged epiphyses (HP:0010580)	4.16757869
20	Resting tremor (HP:0002322)	4.16647820
21	Abnormality of macular pigmentation (HP:0008002)	4.12452802
22	Cone-rod dystrophy (HP:0000548)	3.95505143
23	Abnormal rod and cone electroretinograms (HP:0008323)	3.94111925
24	Facial shape deformation (HP:0011334)	3.83041244
25	Potter facies (HP:0002009)	3.83041244
26	Hypoplastic ischia (HP:0003175)	3.83022410
27	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.79970679
28	Abnormality of the nasal mucosa (HP:0000433)	3.61729994
29	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.38593455
30	Impulsivity (HP:0100710)	3.38385394
31	Abnormality of the ischium (HP:0003174)	3.37279645
32	Azoospermia (HP:0000027)	3.33449170
33	Abnormal spermatogenesis (HP:0008669)	3.33103428
34	Progressive sensorineural hearing impairment (HP:0000408)	3.29885250
35	Hypoplasia of the thymus (HP:0000778)	3.25911850
36	Hypoalphalipoproteinemia (HP:0003233)	3.12433561
37	Generalized aminoaciduria (HP:0002909)	3.04175297
38	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.99346220
39	Postural instability (HP:0002172)	2.93822690
40	Nephronophthisis (HP:0000090)	2.77613136
41	Portal hypertension (HP:0001409)	2.76921366
42	Abnormal urine output (HP:0012590)	2.68564134
43	Renovascular hypertension (HP:0100817)	2.64020340
44	Unilateral renal agenesis (HP:0000122)	2.63773078
45	Rhinitis (HP:0012384)	2.62832737
46	Abnormality of the costochondral junction (HP:0000919)	2.62510520
47	Truncal obesity (HP:0001956)	2.59434101
48	Abnormality of dental color (HP:0011073)	2.56550769
49	Progressive cerebellar ataxia (HP:0002073)	2.54747382
50	Amelogenesis imperfecta (HP:0000705)	2.54595253
51	Stage 5 chronic kidney disease (HP:0003774)	2.53950271
52	Abnormality of the hepatic vasculature (HP:0006707)	2.51733578
53	Abnormality of potassium homeostasis (HP:0011042)	2.49005584
54	Abnormality of the aortic arch (HP:0012303)	2.42642576
55	Tubulointerstitial abnormality (HP:0001969)	2.42080610
56	Insulin-resistant diabetes mellitus (HP:0000831)	2.37916903
57	Menstrual irregularities (HP:0000858)	2.35313628
58	Renal dysplasia (HP:0000110)	2.35202953
59	Flattened epiphyses (HP:0003071)	2.32459868
60	Abnormality of the renal medulla (HP:0100957)	2.31870021
61	Congenital malformation of the right heart (HP:0011723)	2.30271806
62	Double outlet right ventricle (HP:0001719)	2.30271806
63	Abnormality of renal excretion (HP:0011036)	2.29917381
64	Epiphyseal dysplasia (HP:0002656)	2.28298865
65	Abnormal drinking behavior (HP:0030082)	2.23429189
66	Polydipsia (HP:0001959)	2.23429189
67	Widely patent fontanelles and sutures (HP:0004492)	2.18747885
68	Recurrent pneumonia (HP:0006532)	2.18739833
69	Osteomalacia (HP:0002749)	2.14198154
70	Polyuria (HP:0000103)	2.07282512
71	Progressive hearing impairment (HP:0001730)	2.05205597
72	Abnormality of the parathyroid morphology (HP:0011766)	2.03238082
73	Focal segmental glomerulosclerosis (HP:0000097)	2.02910709
74	Hypophosphatemic rickets (HP:0004912)	2.01361126
75	Insidious onset (HP:0003587)	1.99612738
76	Termporal pattern (HP:0011008)	1.99612738
77	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.97879763
78	Bronchiectasis (HP:0002110)	1.96380367
79	Protuberant abdomen (HP:0001538)	1.95055089
80	Ventricular tachycardia (HP:0004756)	1.93177436
81	Absent epiphyses (HP:0010577)	1.93066652
82	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.93066652
83	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.90145001
84	Decreased central vision (HP:0007663)	1.87993010
85	Increased purine levels (HP:0004368)	1.87951023
86	Hyperuricemia (HP:0002149)	1.87951023
87	Flat capital femoral epiphysis (HP:0003370)	1.85642099
88	Abnormality of femoral epiphyses (HP:0006499)	1.84847019
89	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.84847019
90	Myokymia (HP:0002411)	1.84213388
91	Abnormality of the pubic bones (HP:0003172)	1.82994415
92	Intellectual disability, moderate (HP:0002342)	1.80113320
93	Tetany (HP:0001281)	1.80095543
94	Optic nerve hypoplasia (HP:0000609)	1.79041599
95	Hyponatremia (HP:0002902)	1.78215274
96	Renal Fanconi syndrome (HP:0001994)	1.77643315
97	Chronic bronchitis (HP:0004469)	1.77077317
98	Abnormality of the femoral head (HP:0003368)	1.75488582
99	Spastic paraparesis (HP:0002313)	1.74886364
100	Recurrent corneal erosions (HP:0000495)	1.72980295

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.31154183
2	TESK1	5.88067993
3	DDR2	5.51134053
4	INSRR	4.17054500
5	MAP4K2	3.28561833
6	STK38	3.26052269
7	PNCK	3.15401534
8	PLK2	3.00162709
9	BRD4	2.93122758
10	CAMK1G	2.40689228
11	MAPK15	2.32602701
12	STK38L	2.28345448
13	PRKD3	2.11942138
14	MST1R	1.92055149
15	PIK3CG	1.67692417
16	DYRK1B	1.56516195
17	PDPK1	1.48131607
18	WNK1	1.43623898
19	PDK1	1.40215851
20	CDK7	1.16182916
21	NEK6	1.15236380
22	CDK12	1.14104143
23	TYRO3	1.05126109
24	MAP3K11	1.03013232
25	CAMK1D	1.01712028
26	PTK2B	0.99500583
27	KSR2	0.95847874
28	MAP3K9	0.95200106
29	LATS2	0.82592466
30	AKT3	0.78074560
31	ACVR1B	0.75841809
32	SIK2	0.74539386
33	BRAF	0.68571409
34	BMPR1B	0.65238514
35	RPS6KA2	0.64620563
36	PRKG2	0.63511517
37	PRKG1	0.63212181
38	RIPK4	0.60525539
39	GRK7	0.60121357
40	RPS6KA1	0.59718763
41	PRKAA2	0.57795077
42	MAP2K2	0.54035219
43	UHMK1	0.51645758
44	CAMK1	0.48496025
45	ROCK1	0.46629006
46	TESK2	0.46558983
47	JAK3	0.45835405
48	MAP3K2	0.44929092
49	ADRBK2	0.43597332
50	CDK4	0.43337845
51	CDK3	0.43245246
52	MAP3K8	0.43207911
53	TIE1	0.42432510
54	IKBKB	0.41162067
55	RPS6KA6	0.39720980
56	GSK3B	0.39497032
57	MAPK1	0.38193171
58	CHUK	0.38187153
59	CDK2	0.37812381
60	WNK4	0.36997065
61	RPS6KC1	0.36795733
62	RPS6KL1	0.36795733
63	MAP3K1	0.36764693
64	RIPK1	0.36180386
65	DYRK3	0.34687804
66	BLK	0.34416225
67	CDK1	0.32714667
68	SGK223	0.31988514
69	SGK494	0.31988514
70	ARAF	0.31700673
71	MAPK8	0.30746567
72	PRKCZ	0.30047109
73	MOS	0.29508590
74	PKN1	0.28969216
75	MAP3K4	0.27673023
76	PRKCG	0.27347613
77	CAMK4	0.27289224
78	MTOR	0.27002999
79	STK39	0.26203222
80	NTRK3	0.24886125
81	LATS1	0.24454967
82	MUSK	0.23069158
83	MET	0.22952353
84	MARK1	0.22452773
85	PRKCB	0.19703206
86	MAPK14	0.18666677
87	CHEK1	0.17118229
88	MARK2	0.16818247
89	SGK1	0.15217091
90	MAPK10	0.13142131
91	BRSK1	0.12861913
92	AKT1	0.12159090
93	ABL2	0.12100101
94	ICK	0.12044321
95	MAPK11	0.11988419
96	ZAK	0.10662652
97	BRSK2	0.08585629
98	PRKACA	0.07528979
99	MINK1	0.06747552
100	CAMK2A	0.06633804

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.97695398
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	6.62242765
3	Olfactory transduction_Homo sapiens_hsa04740	3.44971455
4	Butanoate metabolism_Homo sapiens_hsa00650	2.71051717
5	Allograft rejection_Homo sapiens_hsa05330	2.24181118
6	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.01004881
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.00130445
8	Type I diabetes mellitus_Homo sapiens_hsa04940	1.88142850
9	Graft-versus-host disease_Homo sapiens_hsa05332	1.84886543
10	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.84748629
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.79199956
12	Type II diabetes mellitus_Homo sapiens_hsa04930	1.69114720
13	Fatty acid degradation_Homo sapiens_hsa00071	1.67203673
14	Antigen processing and presentation_Homo sapiens_hsa04612	1.61845797
15	Fatty acid metabolism_Homo sapiens_hsa01212	1.56884470
16	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.51092506
17	Phenylalanine metabolism_Homo sapiens_hsa00360	1.42732811
18	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.38293350
19	Taste transduction_Homo sapiens_hsa04742	1.34642930
20	Viral myocarditis_Homo sapiens_hsa05416	1.31124688
21	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.29194399
22	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.28586460
23	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.18263057
24	RNA transport_Homo sapiens_hsa03013	1.17793316
25	Influenza A_Homo sapiens_hsa05164	1.13560777
26	Phototransduction_Homo sapiens_hsa04744	1.07404916
27	PPAR signaling pathway_Homo sapiens_hsa03320	1.06529103
28	Endocytosis_Homo sapiens_hsa04144	1.04929782
29	Arginine and proline metabolism_Homo sapiens_hsa00330	0.99717261
30	Protein digestion and absorption_Homo sapiens_hsa04974	0.99020672
31	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.98975730
32	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.90999999
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86500277
34	ABC transporters_Homo sapiens_hsa02010	0.85161312
35	Renin-angiotensin system_Homo sapiens_hsa04614	0.84211651
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81952191
37	Salivary secretion_Homo sapiens_hsa04970	0.79184431
38	Calcium signaling pathway_Homo sapiens_hsa04020	0.74230210
39	Morphine addiction_Homo sapiens_hsa05032	0.73707568
40	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.68616076
41	cAMP signaling pathway_Homo sapiens_hsa04024	0.68402298
42	Selenocompound metabolism_Homo sapiens_hsa00450	0.63650394
43	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.63221123
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.63142475
45	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62581871
46	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.62320305
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.61208192
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.61131116
49	Legionellosis_Homo sapiens_hsa05134	0.53406756
50	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.53243988
51	Nicotine addiction_Homo sapiens_hsa05033	0.51526136
52	Cardiac muscle contraction_Homo sapiens_hsa04260	0.50833357
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50806561
54	VEGF signaling pathway_Homo sapiens_hsa04370	0.49601774
55	Estrogen signaling pathway_Homo sapiens_hsa04915	0.48918726
56	Arginine biosynthesis_Homo sapiens_hsa00220	0.48794831
57	Tyrosine metabolism_Homo sapiens_hsa00350	0.48617187
58	Circadian entrainment_Homo sapiens_hsa04713	0.47851515
59	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.47209646
60	Toxoplasmosis_Homo sapiens_hsa05145	0.46448112
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46349635
62	Acute myeloid leukemia_Homo sapiens_hsa05221	0.46289988
63	African trypanosomiasis_Homo sapiens_hsa05143	0.44907224
64	MAPK signaling pathway_Homo sapiens_hsa04010	0.44133753
65	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.43807852
66	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.42936054
67	Retinol metabolism_Homo sapiens_hsa00830	0.41862449
68	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.40888126
69	Herpes simplex infection_Homo sapiens_hsa05168	0.40654897
70	Malaria_Homo sapiens_hsa05144	0.40126500
71	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.39148539
72	Oocyte meiosis_Homo sapiens_hsa04114	0.37539849
73	Asthma_Homo sapiens_hsa05310	0.35713209
74	Glutamatergic synapse_Homo sapiens_hsa04724	0.35644510
75	Tryptophan metabolism_Homo sapiens_hsa00380	0.34491656
76	Bile secretion_Homo sapiens_hsa04976	0.34418615
77	Prolactin signaling pathway_Homo sapiens_hsa04917	0.34266672
78	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.31292651
79	Serotonergic synapse_Homo sapiens_hsa04726	0.31140102
80	Gastric acid secretion_Homo sapiens_hsa04971	0.31073234
81	Purine metabolism_Homo sapiens_hsa00230	0.27952596
82	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.27060444
83	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.26916063
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.26630585
85	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.25688012
86	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.25593203
87	Renin secretion_Homo sapiens_hsa04924	0.25475282
88	Nitrogen metabolism_Homo sapiens_hsa00910	0.25350575
89	Chemokine signaling pathway_Homo sapiens_hsa04062	0.24316723
90	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.23948285
91	Cholinergic synapse_Homo sapiens_hsa04725	0.23782609
92	Tight junction_Homo sapiens_hsa04530	0.23699523
93	Osteoclast differentiation_Homo sapiens_hsa04380	0.22353708
94	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.20816463
95	Viral carcinogenesis_Homo sapiens_hsa05203	0.20177472
96	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.20130497
97	Leishmaniasis_Homo sapiens_hsa05140	0.19655565
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.19517059
99	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.18220826
100	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.18173902

SPATA31E1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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