SPATA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.81655372
2motile cilium assembly (GO:0044458)9.31295582
3piRNA metabolic process (GO:0034587)9.20494686
4spermatid development (GO:0007286)9.12179202
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.73223968
6cilium movement (GO:0003341)8.64833608
7male meiosis (GO:0007140)8.44373340
8synaptonemal complex organization (GO:0070193)7.82711913
9single fertilization (GO:0007338)7.73954547
10synaptonemal complex assembly (GO:0007130)7.65812214
11regulation of cilium movement (GO:0003352)7.45600061
12sperm capacitation (GO:0048240)6.66726911
13fertilization (GO:0009566)6.53575742
14spermatogenesis (GO:0007283)6.08423662
15behavioral response to nicotine (GO:0035095)6.06461402
16male gamete generation (GO:0048232)6.06294680
17negative regulation of inclusion body assembly (GO:0090084)5.91370512
18DNA methylation involved in gamete generation (GO:0043046)5.90901674
19microtubule depolymerization (GO:0007019)5.74891021
20gamete generation (GO:0007276)5.57436297
21water-soluble vitamin biosynthetic process (GO:0042364)5.50393772
22chromosome organization involved in meiosis (GO:0070192)5.40397141
23ventricular system development (GO:0021591)5.32781386
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.26172878
25male meiosis I (GO:0007141)5.21822933
26germ cell development (GO:0007281)5.20830393
27organic cation transport (GO:0015695)5.14392120
28DNA deamination (GO:0045006)5.07589209
29cell recognition (GO:0008037)5.00940853
30calcium ion-dependent exocytosis (GO:0017156)4.93707553
31regulation of inclusion body assembly (GO:0090083)4.90920039
32seminiferous tubule development (GO:0072520)4.87922743
33meiotic nuclear division (GO:0007126)4.77038876
34monoubiquitinated protein deubiquitination (GO:0035520)4.51120775
35microtubule severing (GO:0051013)4.42569824
36regulation of microtubule-based movement (GO:0060632)4.40745652
37spermatid nucleus differentiation (GO:0007289)4.39683676
38multicellular organismal reproductive process (GO:0048609)4.37709301
39glycerol ether metabolic process (GO:0006662)4.36528520
40sulfation (GO:0051923)4.21739097
41meiosis I (GO:0007127)4.19863833
42genitalia morphogenesis (GO:0035112)4.03672156
43ether metabolic process (GO:0018904)4.03160724
44chaperone-mediated protein complex assembly (GO:0051131)4.00494261
45protein localization to cilium (GO:0061512)3.99599796
46meiotic cell cycle (GO:0051321)3.97686006
47left/right pattern formation (GO:0060972)3.81718226
48indolalkylamine metabolic process (GO:0006586)3.76496307
49protein complex biogenesis (GO:0070271)3.72197324
50gamma-aminobutyric acid transport (GO:0015812)3.71929294
51lactate metabolic process (GO:0006089)3.68823330
52protein K11-linked deubiquitination (GO:0035871)3.68653845
53kynurenine metabolic process (GO:0070189)3.63924109
54multicellular organismal development (GO:0007275)3.57973013
55tryptophan catabolic process (GO:0006569)3.52696064
56indole-containing compound catabolic process (GO:0042436)3.52696064
57indolalkylamine catabolic process (GO:0046218)3.52696064
58GTP biosynthetic process (GO:0006183)3.51063808
59alditol metabolic process (GO:0019400)3.50317539
60intraciliary transport (GO:0042073)3.48541249
61negative regulation of appetite (GO:0032099)3.47966376
62negative regulation of response to food (GO:0032096)3.47966376
63cellular response to ATP (GO:0071318)3.43955962
64polyol catabolic process (GO:0046174)3.41368194
65sequestering of actin monomers (GO:0042989)3.41278579
66somite development (GO:0061053)3.40444866
67gene silencing by RNA (GO:0031047)3.39270793
68negative regulation of transcription regulatory region DNA binding (GO:2000678)3.38235906
69chromosome condensation (GO:0030261)3.37832055
70nucleoside diphosphate phosphorylation (GO:0006165)3.37060777
71synapsis (GO:0007129)3.30610144
72regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.28799383
73fucose catabolic process (GO:0019317)3.27903713
74L-fucose metabolic process (GO:0042354)3.27903713
75L-fucose catabolic process (GO:0042355)3.27903713
76protein polyglutamylation (GO:0018095)3.26578710
77mitochondrial respiratory chain complex assembly (GO:0033108)3.26573096
78cell proliferation in forebrain (GO:0021846)3.23259425
79microtubule-based movement (GO:0007018)3.22327616
80regulation of glomerulus development (GO:0090192)3.20827502
81DNA packaging (GO:0006323)3.18026844
82NADH dehydrogenase complex assembly (GO:0010257)3.16605234
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16605234
84mitochondrial respiratory chain complex I assembly (GO:0032981)3.16605234
85UTP biosynthetic process (GO:0006228)3.14431899
86glycerol metabolic process (GO:0006071)3.14409804
87adaptation of signaling pathway (GO:0023058)3.13984099
88axoneme assembly (GO:0035082)3.11978063
89negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.10844351
90response to pheromone (GO:0019236)3.10534194
91negative regulation of organelle assembly (GO:1902116)3.10083810
92negative regulation of mast cell activation (GO:0033004)3.09773627
93preassembly of GPI anchor in ER membrane (GO:0016254)3.07612137
94meiotic cell cycle process (GO:1903046)3.06409142
95GPI anchor metabolic process (GO:0006505)3.04581438
96single strand break repair (GO:0000012)3.03906448
97platelet dense granule organization (GO:0060155)3.03254391
98carnitine transport (GO:0015879)3.02857485
99amino-acid betaine transport (GO:0015838)3.02857485
100protein neddylation (GO:0045116)3.02610457
101glycolytic process (GO:0006096)3.01842989
102cilium organization (GO:0044782)3.01314950
103positive regulation of fatty acid transport (GO:2000193)3.00411872
104detection of light stimulus involved in visual perception (GO:0050908)2.99088012
105detection of light stimulus involved in sensory perception (GO:0050962)2.99088012
106regulation of protein polyubiquitination (GO:1902914)2.98390951
107primary amino compound metabolic process (GO:1901160)2.97940090
108carnitine transmembrane transport (GO:1902603)2.97548351
109microtubule polymerization or depolymerization (GO:0031109)2.97437358
110serotonin metabolic process (GO:0042428)2.95796302
111indole-containing compound metabolic process (GO:0042430)2.95353964
112sexual reproduction (GO:0019953)2.94968350
113purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.94102480
1143-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.94102480
115regulation of centriole replication (GO:0046599)2.94084790
116cytidine deamination (GO:0009972)2.93340467
117cytidine metabolic process (GO:0046087)2.93340467
118cytidine catabolic process (GO:0006216)2.93340467
119tryptophan metabolic process (GO:0006568)2.93103989
120positive regulation of defense response to virus by host (GO:0002230)2.92672772
121cellular component assembly involved in morphogenesis (GO:0010927)2.91573545
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91495795
123cilium morphogenesis (GO:0060271)2.91469905
124mitotic sister chromatid cohesion (GO:0007064)2.90368414
125mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89748148
126regulation of spindle checkpoint (GO:0090231)2.88115026
127cilium assembly (GO:0042384)2.87831146
128negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87497350
129UTP metabolic process (GO:0046051)2.87015107
130negative regulation of membrane potential (GO:0045837)2.86333657
131transmission of nerve impulse (GO:0019226)2.84618138
132centriole assembly (GO:0098534)2.84247112
133protein refolding (GO:0042026)2.81744881
134positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.81637390
135cytochrome complex assembly (GO:0017004)2.79364795
136regulation of mesoderm development (GO:2000380)2.78678792
137negative regulation of telomere maintenance (GO:0032205)2.77597373
138rRNA catabolic process (GO:0016075)2.75386334
139base-excision repair, AP site formation (GO:0006285)2.74612692
140positive regulation of glomerulus development (GO:0090193)2.73821209
141negative regulation of systemic arterial blood pressure (GO:0003085)2.70109183
142centriole replication (GO:0007099)2.67227599
143regulation of rhodopsin mediated signaling pathway (GO:0022400)2.66896133
144mannosylation (GO:0097502)2.65297234
145nuclear pore complex assembly (GO:0051292)2.63686776
146regulation of action potential (GO:0098900)2.61568121
147endoderm formation (GO:0001706)2.60797799
148vitamin biosynthetic process (GO:0009110)2.59420989
149cornea development in camera-type eye (GO:0061303)2.59067817
150negative regulation of DNA repair (GO:0045738)2.58500687
151nucleus organization (GO:0006997)2.57971772
152tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57871888
153RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57871888
154cellular anion homeostasis (GO:0030002)2.57646122
155negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.55252637
156regulation of female receptivity (GO:0045924)2.54348218
157rhodopsin mediated signaling pathway (GO:0016056)2.52661890
158gene silencing (GO:0016458)2.51628574
159cellular biogenic amine catabolic process (GO:0042402)2.51140730
160amine catabolic process (GO:0009310)2.51140730
161kidney morphogenesis (GO:0060993)2.50268068
162pharyngeal system development (GO:0060037)2.50076266
163pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.48574540
164benzene-containing compound metabolic process (GO:0042537)2.48380999
165pyrimidine ribonucleoside catabolic process (GO:0046133)2.46629655
166parturition (GO:0007567)2.46311121
167energy coupled proton transport, down electrochemical gradient (GO:0015985)2.45575990
168ATP synthesis coupled proton transport (GO:0015986)2.45575990
169photoreceptor cell development (GO:0042461)2.43749911
170regulation of memory T cell differentiation (GO:0043380)2.43624245
171embryonic epithelial tube formation (GO:0001838)2.42205155
172protein-cofactor linkage (GO:0018065)2.42004769
173RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.41223007
174positive regulation of cAMP-mediated signaling (GO:0043950)2.41156455
175nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.38593297
176negative regulation of T cell differentiation in thymus (GO:0033085)2.38464917
177regulation of germinal center formation (GO:0002634)2.37395800
178fusion of sperm to egg plasma membrane (GO:0007342)14.7803558
179cilium or flagellum-dependent cell motility (GO:0001539)13.2870098
180acrosome assembly (GO:0001675)12.7887632
181sperm motility (GO:0030317)12.7861939
182multicellular organism reproduction (GO:0032504)11.7785166
183cell wall macromolecule metabolic process (GO:0044036)11.7590822
184cell wall macromolecule catabolic process (GO:0016998)11.7590822
185sperm-egg recognition (GO:0035036)11.5433618
186plasma membrane fusion (GO:0045026)11.2760353
187binding of sperm to zona pellucida (GO:0007339)10.6817640
188axonemal dynein complex assembly (GO:0070286)10.5783935
189acrosome reaction (GO:0007340)10.3893842
190cell-cell recognition (GO:0009988)10.3380327
191epithelial cilium movement (GO:0003351)10.2458539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.13129238
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.91006905
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.66247494
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84143598
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.81661499
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80961401
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.76333096
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.65531959
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.64403927
10GBX2_23144817_ChIP-Seq_PC3_Human2.60371036
11ZNF274_21170338_ChIP-Seq_K562_Hela2.35233343
12IGF1R_20145208_ChIP-Seq_DFB_Human2.31228468
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.28193835
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24709763
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.11581290
16IRF1_19129219_ChIP-ChIP_H3396_Human2.00363869
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.6587265
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99327594
19CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.95523627
20KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.89510558
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.88810461
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.84305412
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82439584
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81777331
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81357156
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77120489
27* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.75684197
28EWS_26573619_Chip-Seq_HEK293_Human1.75469192
29TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.74918077
30VDR_22108803_ChIP-Seq_LS180_Human1.74762423
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74360501
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68767154
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.67768782
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.67471197
35KAP1_22055183_ChIP-Seq_ESCs_Mouse1.63652264
36STAT1_17558387_ChIP-Seq_HELA_Human1.63284689
37P300_19829295_ChIP-Seq_ESCs_Human1.62148367
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.60575279
39GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.58130491
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57134922
41FUS_26573619_Chip-Seq_HEK293_Human1.55663856
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.55204699
43TAL1_26923725_Chip-Seq_HPCs_Mouse1.53435804
44ER_23166858_ChIP-Seq_MCF-7_Human1.53412825
45KDM2B_26808549_Chip-Seq_REH_Human1.53027374
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.51718123
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.51269612
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51176022
49TP53_22573176_ChIP-Seq_HFKS_Human1.47088199
50AUTS2_25519132_ChIP-Seq_293T-REX_Human1.45570081
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44848486
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44219812
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42569517
54MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40279282
55MYC_18940864_ChIP-ChIP_HL60_Human1.37769815
56FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37117219
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36731069
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34860387
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.34350038
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34350038
61NCOR_22424771_ChIP-Seq_293T_Human1.33983915
62CBP_20019798_ChIP-Seq_JUKART_Human1.33808310
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33808310
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32367040
65GATA3_21867929_ChIP-Seq_CD8_Mouse1.31981728
66BCAT_22108803_ChIP-Seq_LS180_Human1.31665554
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29809965
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.29103224
69* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.28755128
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.25870356
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25424370
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.24810139
73NANOG_19829295_ChIP-Seq_ESCs_Human1.24707492
74SOX2_19829295_ChIP-Seq_ESCs_Human1.24707492
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24395665
76REST_21632747_ChIP-Seq_MESCs_Mouse1.24164918
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.23873386
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23513596
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23231194
80AR_20517297_ChIP-Seq_VCAP_Human1.22785642
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22548270
82GATA3_21867929_ChIP-Seq_TH1_Mouse1.21580634
83RNF2_27304074_Chip-Seq_NSC_Mouse1.21386535
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21359593
85EST1_17652178_ChIP-ChIP_JURKAT_Human1.21221361
86LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.20881851
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19822512
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17876149
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17764274
90SMAD4_21799915_ChIP-Seq_A2780_Human1.17419679
91STAT3_23295773_ChIP-Seq_U87_Human1.16548042
92OCT4_18555785_Chip-Seq_ESCs_Mouse1.15640829
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15583998
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.15398412
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15222283
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15072129
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.14412399
98P53_22387025_ChIP-Seq_ESCs_Mouse1.14313840
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12987399
100JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12126184
101TCF4_23295773_ChIP-Seq_U87_Human1.11653410
102P53_21459846_ChIP-Seq_SAOS-2_Human1.11593630
103TAF15_26573619_Chip-Seq_HEK293_Human1.11378887
104ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11365474
105CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11137728
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.11054289
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10757021
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10486021
109CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10361884
110TAF2_19829295_ChIP-Seq_ESCs_Human1.09659517
111P300_18555785_Chip-Seq_ESCs_Mouse1.09415873
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09100599
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09100599
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09032447
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08910795
116SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08878216
117TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08697847
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08669105
119CMYC_18555785_Chip-Seq_ESCs_Mouse1.07986969
120SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07909889
121GF1_26923725_Chip-Seq_HPCs_Mouse1.07791110
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06826708
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05353923
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05013570
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04399646
126AR_25329375_ChIP-Seq_VCAP_Human1.04074126
127HOXB7_26014856_ChIP-Seq_BT474_Human1.03719320
128MYC_19829295_ChIP-Seq_ESCs_Human1.03127894
129KLF4_18555785_Chip-Seq_ESCs_Mouse1.02913635
130SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02644631
131TCF4_22108803_ChIP-Seq_LS180_Human1.02531613
132PRDM14_20953172_ChIP-Seq_ESCs_Human1.01885107
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01867753
134OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01770773
135RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01070333
136SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00371992
137VDR_23849224_ChIP-Seq_CD4+_Human1.00346504
138ERA_21632823_ChIP-Seq_H3396_Human1.00200595
139ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99241734
140SRF_21415370_ChIP-Seq_HL-1_Mouse0.99198764
141KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98896582
142SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98839029
143NANOG_20526341_ChIP-Seq_ESCs_Human0.98420042
144GATA3_26560356_Chip-Seq_TH2_Human0.98159779
145JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98089370
146STAT3_18555785_Chip-Seq_ESCs_Mouse0.97578662
147ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97436837
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97024172
149FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96541041
150ESET_19884257_ChIP-Seq_ESCs_Mouse0.95260629
151PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95086721
152RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93674577
153SOX9_26525672_Chip-Seq_HEART_Mouse0.92842707
154ERG_20517297_ChIP-Seq_VCAP_Human0.91893772
155PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91258992
156PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91133209
157PU1_27457419_Chip-Seq_LIVER_Mouse0.90301847
158SOX2_18555785_Chip-Seq_ESCs_Mouse0.89811229
159RUNX1_27457419_Chip-Seq_LIVER_Mouse0.88953490
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88718711
161RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88448083
162GF1B_26923725_Chip-Seq_HPCs_Mouse0.88332920
163SPI1_26923725_Chip-Seq_HPCs_Mouse0.87522886
164SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86945711
165E2F1_18555785_Chip-Seq_ESCs_Mouse0.86573017
166SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84790810
167CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84245005
168CTCF_18555785_Chip-Seq_ESCs_Mouse0.83703506
169SMAD4_21741376_ChIP-Seq_EPCs_Human0.83343598
170LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82896930
171FLI1_21867929_ChIP-Seq_CD8_Mouse0.82525314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.09197805
2MP0001929_abnormal_gametogenesis5.64677816
3MP0008877_abnormal_DNA_methylation5.13612192
4MP0002210_abnormal_sex_determination3.74234916
5MP0002837_dystrophic_cardiac_calcinosis3.70068213
6MP0002161_abnormal_fertility/fecundity3.28458678
7MP0001145_abnormal_male_reproductive3.14357943
8MP0005646_abnormal_pituitary_gland2.95436981
9MP0002653_abnormal_ependyma_morphology2.81771886
10MP0000653_abnormal_sex_gland2.73225256
11MP0002876_abnormal_thyroid_physiology2.52830667
12MP0006292_abnormal_olfactory_placode2.40376193
13MP0004885_abnormal_endolymph2.30177646
14MP0003195_calcinosis2.24245001
15MP0004145_abnormal_muscle_electrophysio2.23863508
16MP0008872_abnormal_physiological_respon2.05136542
17MP0005410_abnormal_fertilization15.7716100
18MP0005670_abnormal_white_adipose1.93325408
19MP0005623_abnormal_meninges_morphology1.93117638
20MP0005671_abnormal_response_to1.90767669
21MP0008057_abnormal_DNA_replication1.83910708
22MP0002160_abnormal_reproductive_system1.79404011
23MP0002272_abnormal_nervous_system1.67422733
24MP0000631_abnormal_neuroendocrine_gland1.65334503
25MP0004142_abnormal_muscle_tone1.60731539
26MP0009745_abnormal_behavioral_response1.58476021
27MP0002138_abnormal_hepatobiliary_system1.55173516
28MP0008775_abnormal_heart_ventricle1.51285853
29MP0001485_abnormal_pinna_reflex1.50078793
30MP0008789_abnormal_olfactory_epithelium1.49425583
31MP0004130_abnormal_muscle_cell1.46609184
32MP0000049_abnormal_middle_ear1.41355504
33MP0002735_abnormal_chemical_nociception1.38341913
34MP0002277_abnormal_respiratory_mucosa1.37197948
35MP0002282_abnormal_trachea_morphology1.33000882
36MP0005647_abnormal_sex_gland1.32696062
37MP0005645_abnormal_hypothalamus_physiol1.31141564
38MP0008058_abnormal_DNA_repair1.28466211
39MP0006276_abnormal_autonomic_nervous1.26993443
40MP0001905_abnormal_dopamine_level1.25152539
41MP0001986_abnormal_taste_sensitivity1.24994838
42MP0002638_abnormal_pupillary_reflex1.24681492
43MP0005360_urolithiasis1.24428539
44MP0004742_abnormal_vestibular_system1.23412409
45MP0002733_abnormal_thermal_nociception1.22665665
46MP0001970_abnormal_pain_threshold1.21515313
47MP0001919_abnormal_reproductive_system1.21211914
48MP0005084_abnormal_gallbladder_morpholo1.20131935
49MP0001486_abnormal_startle_reflex1.19497416
50MP0002163_abnormal_gland_morphology1.17778239
51MP0003787_abnormal_imprinting1.15873949
52MP0009046_muscle_twitch1.13472979
53MP0001765_abnormal_ion_homeostasis1.11941714
54MP0003880_abnormal_central_pattern1.11513315
55MP0002557_abnormal_social/conspecific_i1.05151039
56MP0000026_abnormal_inner_ear1.04636753
57MP0003646_muscle_fatigue1.03929930
58MP0003011_delayed_dark_adaptation1.03637214
59MP0003938_abnormal_ear_development1.03093867
60MP0002734_abnormal_mechanical_nocicepti1.01780507
61MP0001963_abnormal_hearing_physiology1.01400221
62MP0004233_abnormal_muscle_weight1.01383159
63MP0010094_abnormal_chromosome_stability1.01227637
64MP0002064_seizures0.99729375
65MP0000230_abnormal_systemic_arterial0.98882344
66MP0001984_abnormal_olfaction0.98688886
67MP0008995_early_reproductive_senescence0.98203402
68MP0000372_irregular_coat_pigmentation0.96370984
69MP0001501_abnormal_sleep_pattern0.96296355
70MP0003638_abnormal_response/metabolism_0.96042379
71MP0002572_abnormal_emotion/affect_behav0.95457550
72MP0003724_increased_susceptibility_to0.95405288
73MP0009764_decreased_sensitivity_to0.92544400
74MP0005389_reproductive_system_phenotype0.91838470
75MP0001440_abnormal_grooming_behavior0.91229980
76MP0004147_increased_porphyrin_level0.90681995
77MP0010386_abnormal_urinary_bladder0.88744868
78MP0003119_abnormal_digestive_system0.84410308
79MP0004215_abnormal_myocardial_fiber0.84332819
80MP0005332_abnormal_amino_acid0.83287051
81MP0003786_premature_aging0.82244290
82MP0001529_abnormal_vocalization0.81118715
83MP0008007_abnormal_cellular_replicative0.80965032
84MP0009780_abnormal_chondrocyte_physiolo0.80222674
85MP0005379_endocrine/exocrine_gland_phen0.78289424
86MP0009053_abnormal_anal_canal0.77907863
87MP0001502_abnormal_circadian_rhythm0.77638970
88MP0002752_abnormal_somatic_nervous0.76240453
89MP0001853_heart_inflammation0.75898535
90MP0003122_maternal_imprinting0.74088121
91MP0003635_abnormal_synaptic_transmissio0.73914068
92MP0000569_abnormal_digit_pigmentation0.72076628
93MP0009250_abnormal_appendicular_skeleto0.71247263
94MP0000613_abnormal_salivary_gland0.69833801
95MP0001873_stomach_inflammation0.69747988
96MP0002148_abnormal_hypersensitivity_rea0.69680238
97MP0005386_behavior/neurological_phenoty0.69339630
98MP0004924_abnormal_behavior0.69339630
99MP0002234_abnormal_pharynx_morphology0.69088274
100MP0003137_abnormal_impulse_conducting0.68930598
101MP0002067_abnormal_sensory_capabilities0.68805965
102MP0010329_abnormal_lipoprotein_level0.68659868
103MP0005499_abnormal_olfactory_system0.68504413
104MP0005394_taste/olfaction_phenotype0.68504413
105MP0005167_abnormal_blood-brain_barrier0.68069843
106MP0004134_abnormal_chest_morphology0.63651061
107MP0005636_abnormal_mineral_homeostasis0.59232749
108MP0003950_abnormal_plasma_membrane0.56961093
109MP0000358_abnormal_cell_content/0.56570605
110MP0005397_hematopoietic_system_phenotyp0.53447326
111MP0001545_abnormal_hematopoietic_system0.53447326
112MP0004019_abnormal_vitamin_homeostasis0.50645482
113MP0010307_abnormal_tumor_latency0.50393303
114MP0005551_abnormal_eye_electrophysiolog0.49389157
115MP0004036_abnormal_muscle_relaxation0.49326477
116MP0002928_abnormal_bile_duct0.48179288
117MP0005253_abnormal_eye_physiology0.46856791
118MP0004808_abnormal_hematopoietic_stem0.46700181
119MP0003699_abnormal_female_reproductive0.45365694
120MP0003329_amyloid_beta_deposits0.45286760
121MP0001324_abnormal_eye_pigmentation0.44941679
122MP0003115_abnormal_respiratory_system0.41579133
123MP0002139_abnormal_hepatobiliary_system0.41445255
124MP0003878_abnormal_ear_physiology0.40944731
125MP0005377_hearing/vestibular/ear_phenot0.40944731
126MP0005666_abnormal_adipose_tissue0.40235794
127MP0001119_abnormal_female_reproductive0.39506388
128MP0003111_abnormal_nucleus_morphology0.35896613
129MP0001764_abnormal_homeostasis0.34091182
130MP0005391_vision/eye_phenotype0.33985971
131MP0006072_abnormal_retinal_apoptosis0.33640784
132MP0001293_anophthalmia0.33390327
133MP0002102_abnormal_ear_morphology0.33320851
134MP0009278_abnormal_bone_marrow0.32366813
135MP0002269_muscular_atrophy0.32209683
136MP0001730_embryonic_growth_arrest0.31943173
137MP0003633_abnormal_nervous_system0.31928740
138MP0001727_abnormal_embryo_implantation0.30834684
139MP0002971_abnormal_brown_adipose0.30792513
140MP0006036_abnormal_mitochondrial_physio0.30730651
141MP0002736_abnormal_nociception_after0.30058506
142MP0009115_abnormal_fat_cell0.26699841
143MP0004133_heterotaxia0.23967462
144MP0000427_abnormal_hair_cycle0.23630382
145MP0003631_nervous_system_phenotype0.23489104
146MP0004811_abnormal_neuron_physiology0.23287339
147MP0000604_amyloidosis0.23095964
148MP0003861_abnormal_nervous_system0.22273459
149MP0002152_abnormal_brain_morphology0.22081941
150MP0000313_abnormal_cell_death0.21521626
151MP0003077_abnormal_cell_cycle0.20459484
152MP0005365_abnormal_bile_salt0.17670928
153MP0003879_abnormal_hair_cell0.16595847
154MP0004084_abnormal_cardiac_muscle0.16282861
155MP0002169_no_abnormal_phenotype0.16113591
156MP0001851_eye_inflammation0.16048209
157MP0002873_normal_phenotype0.15900372
158MP0002092_abnormal_eye_morphology0.15636041
159MP0002229_neurodegeneration0.15559943
160MP0002084_abnormal_developmental_patter0.15406222
161MP0006035_abnormal_mitochondrial_morpho0.15265716
162MP0001968_abnormal_touch/_nociception0.15236752
163MP0004043_abnormal_pH_regulation0.15154510
164MP0000751_myopathy0.15120329
165MP0006138_congestive_heart_failure0.14903481
166MP0005195_abnormal_posterior_eye0.13458981
167MP0008875_abnormal_xenobiotic_pharmacok0.12889058
168MP0001348_abnormal_lacrimal_gland0.12883569
169MP0002970_abnormal_white_adipose0.12681929
170MP0005319_abnormal_enzyme/_coenzyme0.12230842
171MP0005388_respiratory_system_phenotype0.12143398
172MP0002133_abnormal_respiratory_system0.12143398
173MP0000647_abnormal_sebaceous_gland0.11944461
174MP0008961_abnormal_basal_metabolism0.11831588
175MP0000001_mammalian_phenotype0.11659862
176MP0003948_abnormal_gas_homeostasis0.11410204

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.92227962
2Abnormal respiratory epithelium morphology (HP:0012253)9.38552604
3Abnormal respiratory motile cilium morphology (HP:0005938)9.38552604
4Abnormal ciliary motility (HP:0012262)8.25581353
5Rhinitis (HP:0012384)7.92916478
6Chronic bronchitis (HP:0004469)7.83270687
7Nasal polyposis (HP:0100582)6.34701256
8Infertility (HP:0000789)6.31638646
9Abnormality of the nasal mucosa (HP:0000433)5.22262456
10Bronchiectasis (HP:0002110)4.49127309
11Bronchitis (HP:0012387)4.48903038
12Nephronophthisis (HP:0000090)4.07301078
13Pancreatic cysts (HP:0001737)4.03809967
14Recurrent sinusitis (HP:0011108)3.89002120
15Congenital stationary night blindness (HP:0007642)3.64914041
16Methylmalonic acidemia (HP:0002912)3.61275148
17Male infertility (HP:0003251)3.38459959
18Recurrent otitis media (HP:0000403)3.28782450
19Pendular nystagmus (HP:0012043)3.24342157
20Methylmalonic aciduria (HP:0012120)3.21513347
21Absent rod-and cone-mediated responses on ERG (HP:0007688)3.12846766
22Abnormality of the renal medulla (HP:0100957)3.12783841
23Abolished electroretinogram (ERG) (HP:0000550)3.05400979
24Abnormality of the lower motor neuron (HP:0002366)3.02175795
25Abnormal rod and cone electroretinograms (HP:0008323)2.99807773
26Aplasia/Hypoplasia of the spleen (HP:0010451)2.99374043
27Cutaneous melanoma (HP:0012056)2.98580461
28Asplenia (HP:0001746)2.98424331
29Congenital, generalized hypertrichosis (HP:0004540)2.96706048
30Tubulointerstitial nephritis (HP:0001970)2.84727883
31Renal cortical cysts (HP:0000803)2.82716996
32Keratoconus (HP:0000563)2.82543462
33Increased corneal curvature (HP:0100692)2.82543462
34Abnormality of the proximal phalanges of the hand (HP:0009834)2.79404839
35Abnormal spermatogenesis (HP:0008669)2.75681053
36IgG deficiency (HP:0004315)2.73625718
373-Methylglutaconic aciduria (HP:0003535)2.73262559
38Agitation (HP:0000713)2.68594878
39Gonadotropin excess (HP:0000837)2.66004408
40Attenuation of retinal blood vessels (HP:0007843)2.58996831
41Medial flaring of the eyebrow (HP:0010747)2.58828828
42Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.57601776
43Aplasia/hypoplasia of the uterus (HP:0008684)2.51901612
44Molar tooth sign on MRI (HP:0002419)2.51180607
45Abnormality of midbrain morphology (HP:0002418)2.51180607
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.47902861
47Hyperglycinemia (HP:0002154)2.47797101
48Short tibia (HP:0005736)2.47018927
49Hypoplasia of the uterus (HP:0000013)2.46684798
50Type II lissencephaly (HP:0007260)2.45489773
51Acute necrotizing encephalopathy (HP:0006965)2.45196736
52Abnormality of the middle phalanges of the toes (HP:0010183)2.43724090
53Fibular hypoplasia (HP:0003038)2.41468580
54Mitochondrial inheritance (HP:0001427)2.41308200
55Abnormality of the phalanges of the 5th finger (HP:0004213)2.38412524
56Genetic anticipation (HP:0003743)2.38096321
57Amyotrophic lateral sclerosis (HP:0007354)2.37777425
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.32346130
59Tubular atrophy (HP:0000092)2.29117018
60Progressive macrocephaly (HP:0004481)2.28543654
61Symphalangism affecting the phalanges of the hand (HP:0009773)2.26629322
62Tubulointerstitial abnormality (HP:0001969)2.26347368
63Recurrent bronchitis (HP:0002837)2.25991271
64Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.22709038
65Increased CSF lactate (HP:0002490)2.22333674
66Abnormal mitochondria in muscle tissue (HP:0008316)2.22251443
67Congenital sensorineural hearing impairment (HP:0008527)2.21590981
68Sclerocornea (HP:0000647)2.21253666
69Furrowed tongue (HP:0000221)2.20101237
70Progressive cerebellar ataxia (HP:0002073)2.17084604
71Hepatocellular necrosis (HP:0001404)2.13611241
72Thyroid-stimulating hormone excess (HP:0002925)2.10201966
73Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09444164
74Thyroiditis (HP:0100646)2.08910615
75Chorioretinal atrophy (HP:0000533)2.05376761
76Acute encephalopathy (HP:0006846)2.02353020
77Gaze-evoked nystagmus (HP:0000640)2.01352838
78Abnormality of vitamin B metabolism (HP:0004340)2.01340691
79Abnormality of the vitamin B12 metabolism (HP:0004341)2.00801427
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8548995
81Dynein arm defect of respiratory motile cilia (HP:0012255)13.6272288
82Absent/shortened dynein arms (HP:0200106)13.6272288
83Male pseudohermaphroditism (HP:0000037)1.99808373
84Morphological abnormality of the middle ear (HP:0008609)1.96576511
85Short femoral neck (HP:0100864)1.94600002
86Hepatic necrosis (HP:0002605)1.94364242
87Azoospermia (HP:0000027)1.94209170
88Postaxial foot polydactyly (HP:0001830)1.92797460
89Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.91767419
90Short 1st metacarpal (HP:0010034)1.91767419
91Aplasia/Hypoplasia of the hallux (HP:0008362)1.91691793
92Synostosis involving the elbow (HP:0003938)1.90608930
93Humeroradial synostosis (HP:0003041)1.90608930
94Short hallux (HP:0010109)1.87710873
95Hemiparesis (HP:0001269)1.87462974
96Stage 5 chronic kidney disease (HP:0003774)1.83625273
97Impulsivity (HP:0100710)1.83163253
98Taurodontia (HP:0000679)1.81937373
99Abnormality of permanent molar morphology (HP:0011071)1.81937373
100Abnormality of the dental root (HP:0006486)1.81937373
101Abnormality of the nasal septum (HP:0000419)1.79221005
102Severe visual impairment (HP:0001141)1.79017915
103Impaired proprioception (HP:0010831)1.78899613
104Mesomelia (HP:0003027)1.78559778
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77352863
106Abnormality of alanine metabolism (HP:0010916)1.77352863
107Hyperalaninemia (HP:0003348)1.77352863
108Chronic hepatic failure (HP:0100626)1.76323839
109Goiter (HP:0000853)1.75696386
110Porencephaly (HP:0002132)1.75628939
111Anencephaly (HP:0002323)1.75435565
112Bony spicule pigmentary retinopathy (HP:0007737)1.75192167
113Abnormality of the renal cortex (HP:0011035)1.74892950
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74652321
115Fibular aplasia (HP:0002990)1.74320310
116Dicarboxylic aciduria (HP:0003215)1.73863931
117Absent frontal sinuses (HP:0002688)1.70726340
118Upper motor neuron abnormality (HP:0002127)1.70348065
119Congenital hepatic fibrosis (HP:0002612)1.69901898
120Abnormality of molar (HP:0011077)1.69447828
121Abnormality of molar morphology (HP:0011070)1.69447828
122Tubulointerstitial fibrosis (HP:0005576)1.68683140
123Abnormality of the dental pulp (HP:0006479)1.66232907
124Chronic sinusitis (HP:0011109)1.65896721
125Abnormality of dentin (HP:0010299)1.63607304
126Oculomotor apraxia (HP:0000657)1.62338292
127Microglossia (HP:0000171)1.60708518
128J-shaped sella turcica (HP:0002680)1.60346976
129Gait imbalance (HP:0002141)1.58627083
130Congenital primary aphakia (HP:0007707)1.58204616
131Short ribs (HP:0000773)1.57723016
132Supernumerary spleens (HP:0009799)1.54216212
133Aplasia/Hypoplasia of the fibula (HP:0006492)1.53690149
134Abnormality of renal excretion (HP:0011036)1.53303946
13511 pairs of ribs (HP:0000878)1.52962365
136Polydipsia (HP:0001959)1.52139061
137Abnormal drinking behavior (HP:0030082)1.52139061
138Postaxial hand polydactyly (HP:0001162)1.50429785
139Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.50236147
140Renal dysplasia (HP:0000110)1.47971867
141Abnormality of the anterior horn cell (HP:0006802)1.47316273
142Degeneration of anterior horn cells (HP:0002398)1.47316273
143Breast carcinoma (HP:0003002)1.45767357
144Facial cleft (HP:0002006)1.45428258
145Cystic liver disease (HP:0006706)1.43450594
146Spastic tetraparesis (HP:0001285)1.43073403
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.42323721
148Dyschromatopsia (HP:0007641)1.41861841
149Cholecystitis (HP:0001082)1.40426180
150Abnormal gallbladder physiology (HP:0012438)1.40426180
151Absent epiphyses (HP:0010577)1.37014837
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.37014837
153Pancreatic fibrosis (HP:0100732)1.36959727
154Nephrogenic diabetes insipidus (HP:0009806)1.34554109
155Vascular calcification (HP:0004934)1.34501503
156Heterotopia (HP:0002282)1.32519204
157Aplasia/Hypoplasia of the lens (HP:0008063)1.30588701
158Deformed sella turcica (HP:0002681)1.25382932
159Bell-shaped thorax (HP:0001591)1.24941238
160Decreased central vision (HP:0007663)1.23713741
161Selective tooth agenesis (HP:0001592)1.23600792
162Broad distal phalanx of finger (HP:0009836)1.23249707
163Hypoplasia of dental enamel (HP:0006297)1.22753362
164Cardiovascular calcification (HP:0011915)1.21263532
165Median cleft lip (HP:0000161)1.21129376
166Short thorax (HP:0010306)1.20588164
167True hermaphroditism (HP:0010459)1.20412321
168Large eyes (HP:0001090)1.20172941
169Asymmetric septal hypertrophy (HP:0001670)1.19823953
170Bile duct proliferation (HP:0001408)1.19037260
171Abnormal biliary tract physiology (HP:0012439)1.19037260
172Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.18246138
173Abnormality of ocular smooth pursuit (HP:0000617)1.17951799
174Poor coordination (HP:0002370)1.17850799
175Vaginal atresia (HP:0000148)1.15897973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.75206801
2PDK39.75206801
3PDK26.34926624
4FRK5.29083844
5TESK13.67522322
6ADRBK23.55630824
7GRK13.39993545
8MAP4K23.14022944
9TXK3.02348703
10TAOK33.00061475
11PRKD32.95049468
12ICK2.61168818
13TLK12.49023167
14WNK42.17040714
15ZAK2.16305374
16PTK2B2.13337548
17STK392.12248903
18PNCK2.09995147
19NUAK12.03862593
20BCKDK1.89677621
21INSRR1.67847117
22NEK21.59445038
23MAPK131.58613624
24TIE11.37104584
25MAPKAPK31.31871769
26IKBKB1.28548780
27TEC1.23340669
28OXSR11.22844654
29CSNK1G31.22621677
30GRK61.20187187
31CSNK1G21.18847609
32ITK1.13797001
33DYRK21.12451691
34STK381.10424076
35MST41.08995660
36ADRBK11.08769440
37PLK21.04098154
38CSNK1G11.03582958
39KDR0.99821908
40PDK10.99100111
41STK160.97337397
42DAPK20.96773308
43GRK70.95322113
44CSNK1A1L0.94639492
45PRKCE0.94515734
46WNK10.92018255
47FGFR20.88374084
48FES0.88073533
49DYRK1B0.87505111
50CCNB10.86866821
51PAK30.85336626
52TYRO30.84478081
53PASK0.83113840
54MAPK150.82720761
55ACVR1B0.82398442
56KIT0.82214358
57NME10.82004781
58PHKG20.78381510
59PHKG10.78381510
60GRK50.75505936
61IRAK10.75212588
62STK30.75154267
63DYRK30.69477073
64MAP4K10.68639703
65MAP2K20.67985782
66RPS6KA50.67797253
67VRK10.66747419
68SYK0.65725707
69TRIM280.64506810
70CSNK1A10.64319832
71PRKD20.64115221
72CASK0.63865983
73VRK20.62369933
74CDC70.62271308
75LMTK20.60621298
76FLT30.60114219
77BCR0.59912586
78EPHA30.59163253
79TTK0.58187400
80ERBB20.56374679
81PIK3CA0.56059055
82CAMKK20.55751985
83OBSCN0.53466468
84IGF1R0.52390136
85PINK10.52185321
86WEE10.50733501
87PRKCI0.49704068
88LYN0.49436111
89LCK0.49250854
90NTRK30.49042670
91BTK0.48665747
92ERBB30.47718592
93IKBKE0.47108074
94TESK20.46952796
95CHEK20.46354038
96CDK80.45784253
97CHEK10.43923923
98MAP2K60.43202673
99CAMK1G0.42695454
100TNK20.41427892
101ABL10.40899119
102ATR0.39807621
103CHUK0.39462851
104MYLK0.37962920
105FER0.37387169
106PDPK10.36782930
107PLK40.36660805
108STK38L0.35782053
109EPHA40.34443972
110PIK3CG0.33142301
111DAPK10.31987574
112ATM0.30280423
113NTRK20.29661393
114CAMK10.29226245
115CAMKK10.27210808
116RIPK40.25032474
117BMPR1B0.24741830
118PAK10.24567477
119IRAK20.24443482
120MUSK0.23910584
121EEF2K0.23697110
122PRKCG0.22677949
123MAP3K100.22223989
124PLK10.21558069
125MTOR0.18492068
126MAPKAPK50.18175990
127PAK20.17026113
128RPS6KB10.15559428
129PRKAA10.14688159
130BRSK20.14468886
131BRAF0.13045971
132CDK120.12140009
133MARK20.11152028
134NEK60.10197675
135PRKG10.09529521
136CDK150.09421797
137PRKACG0.09154962
138MAP3K40.08686881
139CDK180.07296325
140CSNK1D0.07283708
141MARK30.06963135
142WNK30.06774679
143PRKCQ0.06507777
144PRKCZ0.05928810
145CDK11A0.05927098
146CSNK2A10.05610139
147CDK140.04265261
148CDK10.03954459
149PRKG20.03913871
150PKN10.03358688
151PRKACB0.03169269
152MAPK80.02917073
153GSK3B0.02168184
154CDK20.02028700
155BRSK10.01997664
156PRKDC0.01675293
157STK100.01670659
158CSNK2A20.01091587
159MINK1-0.0424859
160PAK4-0.0416528
161CDK3-0.0388816
162INSR-0.0385944
163MAP2K7-0.0361579
164MARK1-0.0344672
165PDGFRB-0.0292564
166MAPK10-0.0250363
167PRKACA-0.0211107
168PRKCA-0.0192183
169STK11-0.0114229
170PAK6-0.0090719
171EGFR-0.0081265
172CAMK2A-0.0079921
173CSF1R-0.0041271
174RPS6KA3-0.0039310
175RPS6KA1-0.0032523
176PRKCB-0.0015156

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.80077726
2Pyruvate metabolism_Homo sapiens_hsa006204.59861783
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.43489932
4Propanoate metabolism_Homo sapiens_hsa006403.76912270
5Fatty acid biosynthesis_Homo sapiens_hsa000613.19322964
6Glucagon signaling pathway_Homo sapiens_hsa049222.99441728
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.88964697
8Oxidative phosphorylation_Homo sapiens_hsa001902.84018927
9Phototransduction_Homo sapiens_hsa047442.73472442
10Pentose phosphate pathway_Homo sapiens_hsa000302.59792518
11Basal transcription factors_Homo sapiens_hsa030222.53949868
12Selenocompound metabolism_Homo sapiens_hsa004502.38097798
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.28688390
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.21790022
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.19538402
16Parkinsons disease_Homo sapiens_hsa050122.16607260
17Linoleic acid metabolism_Homo sapiens_hsa005912.13356148
18Protein export_Homo sapiens_hsa030601.98797605
19Oocyte meiosis_Homo sapiens_hsa041141.98562107
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.97585331
21Nicotine addiction_Homo sapiens_hsa050331.96557482
22Fanconi anemia pathway_Homo sapiens_hsa034601.92561809
23Primary immunodeficiency_Homo sapiens_hsa053401.91765790
24Glycerolipid metabolism_Homo sapiens_hsa005611.89001274
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86756181
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83438384
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.82167047
28Dorso-ventral axis formation_Homo sapiens_hsa043201.77560931
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.76025996
30Nitrogen metabolism_Homo sapiens_hsa009101.75938050
31PPAR signaling pathway_Homo sapiens_hsa033201.72051539
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.71755418
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70934989
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.70765626
35Asthma_Homo sapiens_hsa053101.69816532
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63712636
37Tryptophan metabolism_Homo sapiens_hsa003801.61904970
38Amphetamine addiction_Homo sapiens_hsa050311.61280809
39Caffeine metabolism_Homo sapiens_hsa002321.60036272
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.58828969
41Huntingtons disease_Homo sapiens_hsa050161.55761209
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.55065267
43RNA polymerase_Homo sapiens_hsa030201.53388223
44Carbon metabolism_Homo sapiens_hsa012001.52252380
45Alzheimers disease_Homo sapiens_hsa050101.45654016
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44939372
47Renin secretion_Homo sapiens_hsa049241.42804766
48Graft-versus-host disease_Homo sapiens_hsa053321.41702276
49Morphine addiction_Homo sapiens_hsa050321.34800448
50Allograft rejection_Homo sapiens_hsa053301.34796423
51Autoimmune thyroid disease_Homo sapiens_hsa053201.33830922
52Homologous recombination_Homo sapiens_hsa034401.30435132
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29581028
54Type I diabetes mellitus_Homo sapiens_hsa049401.26108893
55Fructose and mannose metabolism_Homo sapiens_hsa000511.25737547
56Proteasome_Homo sapiens_hsa030501.25430608
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23622889
58Cardiac muscle contraction_Homo sapiens_hsa042601.20355374
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20246137
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18982355
61Peroxisome_Homo sapiens_hsa041461.15851114
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15803411
63Butanoate metabolism_Homo sapiens_hsa006501.14602032
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13975284
65Biosynthesis of amino acids_Homo sapiens_hsa012301.12279339
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07962638
67Glycerophospholipid metabolism_Homo sapiens_hsa005641.07151226
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06797315
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04860573
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02306378
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01176776
72Purine metabolism_Homo sapiens_hsa002300.99769582
73Mineral absorption_Homo sapiens_hsa049780.99424509
74mRNA surveillance pathway_Homo sapiens_hsa030150.98941750
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98777669
76Fatty acid metabolism_Homo sapiens_hsa012120.97371785
77Fat digestion and absorption_Homo sapiens_hsa049750.96518360
78Fatty acid degradation_Homo sapiens_hsa000710.94933409
79GABAergic synapse_Homo sapiens_hsa047270.94445358
80Long-term potentiation_Homo sapiens_hsa047200.93393543
81Ether lipid metabolism_Homo sapiens_hsa005650.92906933
82RNA transport_Homo sapiens_hsa030130.92151597
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91366293
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91050660
85Serotonergic synapse_Homo sapiens_hsa047260.89437274
86Antigen processing and presentation_Homo sapiens_hsa046120.89259362
87Rheumatoid arthritis_Homo sapiens_hsa053230.87943650
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85283398
89Collecting duct acid secretion_Homo sapiens_hsa049660.84204777
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79924499
91Regulation of autophagy_Homo sapiens_hsa041400.79595048
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78524641
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78189839
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75633140
95Ribosome_Homo sapiens_hsa030100.73646189
96Glutathione metabolism_Homo sapiens_hsa004800.73447427
97Hematopoietic cell lineage_Homo sapiens_hsa046400.72023626
98Chemical carcinogenesis_Homo sapiens_hsa052040.71739665
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71573353
100Sulfur relay system_Homo sapiens_hsa041220.68457022
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68339173
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.68119000
103ABC transporters_Homo sapiens_hsa020100.66248101
104One carbon pool by folate_Homo sapiens_hsa006700.64943096
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63712733
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.62280483
107Calcium signaling pathway_Homo sapiens_hsa040200.61563732
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59792828
109Estrogen signaling pathway_Homo sapiens_hsa049150.59208487
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59172279
111beta-Alanine metabolism_Homo sapiens_hsa004100.57378758
112VEGF signaling pathway_Homo sapiens_hsa043700.57069822
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53277365
114Insulin secretion_Homo sapiens_hsa049110.51767670
115Vitamin digestion and absorption_Homo sapiens_hsa049770.47379722
116Bile secretion_Homo sapiens_hsa049760.47282640
117Inositol phosphate metabolism_Homo sapiens_hsa005620.46771619
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46318128
119Type II diabetes mellitus_Homo sapiens_hsa049300.45552019
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44836850
121Thyroid hormone synthesis_Homo sapiens_hsa049180.43877449
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.41887255
123Arachidonic acid metabolism_Homo sapiens_hsa005900.40701794
124Synaptic vesicle cycle_Homo sapiens_hsa047210.40582736
125N-Glycan biosynthesis_Homo sapiens_hsa005100.40223853
126Metabolic pathways_Homo sapiens_hsa011000.39524636
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39136627
128AMPK signaling pathway_Homo sapiens_hsa041520.37297859
129Histidine metabolism_Homo sapiens_hsa003400.37003203
130Nucleotide excision repair_Homo sapiens_hsa034200.36033993
131Legionellosis_Homo sapiens_hsa051340.34069569
132Renin-angiotensin system_Homo sapiens_hsa046140.31839540
133Ovarian steroidogenesis_Homo sapiens_hsa049130.31451148
134Hedgehog signaling pathway_Homo sapiens_hsa043400.30928734
135B cell receptor signaling pathway_Homo sapiens_hsa046620.30800633
136Circadian entrainment_Homo sapiens_hsa047130.29536863
137Endocytosis_Homo sapiens_hsa041440.28798668
138Dopaminergic synapse_Homo sapiens_hsa047280.28438074
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28276916
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28160938
141Sulfur metabolism_Homo sapiens_hsa009200.28078827
142Taste transduction_Homo sapiens_hsa047420.27854089
143Salivary secretion_Homo sapiens_hsa049700.26755166
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25322189
145Pancreatic secretion_Homo sapiens_hsa049720.25105501
146Gastric acid secretion_Homo sapiens_hsa049710.23161789
147Systemic lupus erythematosus_Homo sapiens_hsa053220.23142894
148Protein digestion and absorption_Homo sapiens_hsa049740.23131979
149Vascular smooth muscle contraction_Homo sapiens_hsa042700.23058015
150cAMP signaling pathway_Homo sapiens_hsa040240.21841936
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21737060
152Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21605537
153Steroid hormone biosynthesis_Homo sapiens_hsa001400.19315534
154Wnt signaling pathway_Homo sapiens_hsa043100.19047843
155Pyrimidine metabolism_Homo sapiens_hsa002400.18911811
156Glutamatergic synapse_Homo sapiens_hsa047240.17959523
157Olfactory transduction_Homo sapiens_hsa047400.17810707
158Retinol metabolism_Homo sapiens_hsa008300.17110387
159Cell cycle_Homo sapiens_hsa041100.14434445
160RNA degradation_Homo sapiens_hsa030180.09874204
161Oxytocin signaling pathway_Homo sapiens_hsa049210.07381994

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