SPATA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ATPase associated with diverse activities family, whose members are defined by a highly conserved ATPase domain. Members of this family participate in diverse cellular processes that include membrane fusion, DNA replication, microtubule severing, and protein degradation. The protein encoded by this gene has a putative mitochondrial targeting sequence and has been proposed to function in maintenance of mitochondrial function and integrity during mouse spermatogenesis. Allelic variants in this gene have been associated with epilepsy, hearing loss, and mental retardation syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.95175735
2nuclear pore complex assembly (GO:0051292)5.66187547
3nuclear pore organization (GO:0006999)5.59192069
4DNA methylation involved in gamete generation (GO:0043046)4.72504108
5synaptonemal complex assembly (GO:0007130)4.53505923
6pore complex assembly (GO:0046931)4.34583104
7mitotic nuclear envelope disassembly (GO:0007077)4.26639995
8male meiosis (GO:0007140)4.16361904
9meiotic chromosome segregation (GO:0045132)4.15637859
10protein localization to kinetochore (GO:0034501)4.15304643
11synaptonemal complex organization (GO:0070193)4.14286923
12DNA replication-dependent nucleosome assembly (GO:0006335)4.14010628
13DNA replication-dependent nucleosome organization (GO:0034723)4.14010628
14replication fork processing (GO:0031297)4.10628314
15mitotic chromosome condensation (GO:0007076)4.04647318
16negative regulation of DNA-dependent DNA replication (GO:2000104)4.04414085
17DNA unwinding involved in DNA replication (GO:0006268)4.03818020
18kinetochore organization (GO:0051383)3.99943585
19membrane disassembly (GO:0030397)3.99613921
20nuclear envelope disassembly (GO:0051081)3.99613921
21mitotic metaphase plate congression (GO:0007080)3.96761838
22DNA replication initiation (GO:0006270)3.91515493
23DNA replication checkpoint (GO:0000076)3.89212429
24regulation of meiosis I (GO:0060631)3.88116366
25chromatin remodeling at centromere (GO:0031055)3.85323234
26attachment of spindle microtubules to kinetochore (GO:0008608)3.85062068
27metaphase plate congression (GO:0051310)3.79117006
28chromosome organization involved in meiosis (GO:0070192)3.77096574
29gene silencing by RNA (GO:0031047)3.77014408
30meiotic nuclear division (GO:0007126)3.75530844
31behavioral response to nicotine (GO:0035095)3.73943213
32DNA strand elongation involved in DNA replication (GO:0006271)3.72849631
33protein localization to chromosome, centromeric region (GO:0071459)3.71288769
34mitotic sister chromatid cohesion (GO:0007064)3.70159024
35CENP-A containing nucleosome assembly (GO:0034080)3.65279157
36maturation of SSU-rRNA (GO:0030490)3.65062056
37recombinational repair (GO:0000725)3.64122469
38DNA double-strand break processing (GO:0000729)3.63516678
39double-strand break repair via homologous recombination (GO:0000724)3.62910547
40regulation of mitotic spindle checkpoint (GO:1903504)3.60428194
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.60428194
42DNA replication-independent nucleosome assembly (GO:0006336)3.57544571
43DNA replication-independent nucleosome organization (GO:0034724)3.57544571
44rRNA catabolic process (GO:0016075)3.54960748
45DNA strand elongation (GO:0022616)3.54150852
46histone exchange (GO:0043486)3.52932320
47regulation of histone H3-K9 methylation (GO:0051570)3.51154495
48RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.50588615
49kinetochore assembly (GO:0051382)3.49570809
50synapsis (GO:0007129)3.46946136
51telomere maintenance via semi-conservative replication (GO:0032201)3.46717640
52protein K11-linked deubiquitination (GO:0035871)3.46629162
53regulation of nuclear cell cycle DNA replication (GO:0033262)3.46469859
54centriole replication (GO:0007099)3.45606421
55formation of translation preinitiation complex (GO:0001731)3.40404238
56regulation of DNA endoreduplication (GO:0032875)3.39629521
57maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.38356335
58protein K6-linked ubiquitination (GO:0085020)3.37490089
59nucleobase biosynthetic process (GO:0046112)3.36909437
60telomere maintenance via recombination (GO:0000722)3.34864408
61mitotic recombination (GO:0006312)3.34348672
62fucose catabolic process (GO:0019317)3.33212956
63L-fucose metabolic process (GO:0042354)3.33212956
64L-fucose catabolic process (GO:0042355)3.33212956
65DNA synthesis involved in DNA repair (GO:0000731)3.31883170
66purine nucleobase biosynthetic process (GO:0009113)3.29484031
67IMP biosynthetic process (GO:0006188)3.28713295
68ribosome biogenesis (GO:0042254)3.27692562
69regulation of spindle organization (GO:0090224)3.24867454
70establishment of chromosome localization (GO:0051303)3.21891606
71ribosome assembly (GO:0042255)3.21186320
72regulation of chromosome segregation (GO:0051983)3.19956678
73sister chromatid cohesion (GO:0007062)3.19740226
74negative regulation of chromosome segregation (GO:0051985)3.18105659
75translesion synthesis (GO:0019985)3.18091233
76regulation of centriole replication (GO:0046599)3.16603702
77DNA geometric change (GO:0032392)3.16504423
78spindle checkpoint (GO:0031577)3.16429039
79negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16011118
80negative regulation of sister chromatid segregation (GO:0033046)3.16011118
81negative regulation of mitotic sister chromatid separation (GO:2000816)3.16011118
82negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16011118
83meiotic cell cycle process (GO:1903046)3.15500035
84DNA duplex unwinding (GO:0032508)3.15391456
85spindle assembly checkpoint (GO:0071173)3.13551230
86regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13414349
87negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.12641894
88negative regulation of translation, ncRNA-mediated (GO:0040033)3.12641894
89regulation of translation, ncRNA-mediated (GO:0045974)3.12641894
90regulation of centrosome duplication (GO:0010824)3.12390993
91chromatin assembly or disassembly (GO:0006333)3.11868729
92folic acid-containing compound biosynthetic process (GO:0009396)3.10150279
93mitotic sister chromatid segregation (GO:0000070)3.09944047
94mitotic spindle assembly checkpoint (GO:0007094)3.09264654
95reciprocal DNA recombination (GO:0035825)3.07929398
96reciprocal meiotic recombination (GO:0007131)3.07929398
97water-soluble vitamin biosynthetic process (GO:0042364)3.07624279
98mitotic spindle checkpoint (GO:0071174)3.07439892
99negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07214904
100male meiosis I (GO:0007141)3.07080705
101DNA deamination (GO:0045006)3.07013450
102regulation of double-strand break repair via homologous recombination (GO:0010569)3.07005708
103regulation of centrosome cycle (GO:0046605)3.06846241
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.06676293
105regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06585875
106nuclear envelope organization (GO:0006998)3.06465962
107positive regulation of chromosome segregation (GO:0051984)3.04691054
108somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04396234
109somatic hypermutation of immunoglobulin genes (GO:0016446)3.04396234
110DNA alkylation (GO:0006305)3.04169907
111DNA methylation (GO:0006306)3.04169907
112heterochromatin organization (GO:0070828)3.04061441
113postreplication repair (GO:0006301)3.03944422
114somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.03855272
115somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.03855272
116isotype switching (GO:0045190)3.03855272
117sister chromatid segregation (GO:0000819)3.03614603
118positive regulation of mitotic sister chromatid separation (GO:1901970)3.03477678
119positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03477678
120positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03477678
121exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03287756
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03218767
123protein localization to chromosome (GO:0034502)3.01819906
124regulation of sister chromatid segregation (GO:0033045)3.00880347
125regulation of mitotic sister chromatid separation (GO:0010965)3.00880347
126regulation of mitotic sister chromatid segregation (GO:0033047)3.00880347
127regulation of helicase activity (GO:0051095)3.00773364
128telomere maintenance via telomere lengthening (GO:0010833)2.99801639
129ncRNA catabolic process (GO:0034661)2.99292345
130resolution of meiotic recombination intermediates (GO:0000712)2.98851867
131positive regulation of histone H3-K4 methylation (GO:0051571)2.98278723
132regulation of RNA export from nucleus (GO:0046831)2.97370726
133maturation of 5.8S rRNA (GO:0000460)2.94733178
134histone-serine phosphorylation (GO:0035404)2.91861869
135microtubule depolymerization (GO:0007019)2.89055937
136somatic diversification of immunoglobulins (GO:0016445)2.82852186
137response to pheromone (GO:0019236)2.82632474
138centrosome organization (GO:0051297)2.82074471
139double-strand break repair (GO:0006302)2.76406873
140pseudouridine synthesis (GO:0001522)2.76249469
141DNA-dependent DNA replication (GO:0006261)2.75984151
142somatic recombination of immunoglobulin gene segments (GO:0016447)2.74392489
143DNA recombination (GO:0006310)2.73103013
144replicative senescence (GO:0090399)2.71651474
145microtubule organizing center organization (GO:0031023)2.68494213
146prenylation (GO:0097354)2.67996367
147protein prenylation (GO:0018342)2.67996367
148microtubule anchoring (GO:0034453)2.66163623
149detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.65728712
150protein polyglutamylation (GO:0018095)2.63444143
151meiotic cell cycle (GO:0051321)2.60882159
152respiratory chain complex IV assembly (GO:0008535)2.60391073
153negative regulation of DNA recombination (GO:0045910)2.58648862
154indolalkylamine metabolic process (GO:0006586)2.56321328
155DNA catabolic process, exonucleolytic (GO:0000738)2.55765948
156somatic diversification of immune receptors (GO:0002200)2.53916218
157non-recombinational repair (GO:0000726)2.53547112
158double-strand break repair via nonhomologous end joining (GO:0006303)2.53547112
159ubiquinone metabolic process (GO:0006743)2.51759262
160mitochondrial RNA metabolic process (GO:0000959)2.50494469
161neural tube formation (GO:0001841)2.50115278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.70631053
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.54345290
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.19186538
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.05605206
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.81812992
6ZNF274_21170338_ChIP-Seq_K562_Hela3.30114074
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.23692390
8VDR_22108803_ChIP-Seq_LS180_Human2.80202033
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75662769
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.66922952
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64910514
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.64673350
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.57203986
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.53650710
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48647778
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.47119371
17EWS_26573619_Chip-Seq_HEK293_Human2.46310511
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.44736420
19FUS_26573619_Chip-Seq_HEK293_Human2.43827692
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41198409
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35414559
22* GABP_17652178_ChIP-ChIP_JURKAT_Human2.32821277
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32404125
24AR_21909140_ChIP-Seq_LNCAP_Human2.31231556
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.25092305
26GBX2_23144817_ChIP-Seq_PC3_Human2.24064515
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23842243
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16685548
29* VDR_23849224_ChIP-Seq_CD4+_Human2.16336175
30IGF1R_20145208_ChIP-Seq_DFB_Human2.15702018
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.13826445
32* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.12693671
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09059023
34XRN2_22483619_ChIP-Seq_HELA_Human2.08052678
35FLI1_27457419_Chip-Seq_LIVER_Mouse2.06634079
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05116935
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00421583
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97056704
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95218529
40TAF15_26573619_Chip-Seq_HEK293_Human1.93458725
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92018811
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87272586
43IRF1_19129219_ChIP-ChIP_H3396_Human1.82049044
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81369622
45* FOXP3_21729870_ChIP-Seq_TREG_Human1.80080710
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79354327
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79194992
48* P300_19829295_ChIP-Seq_ESCs_Human1.77878113
49ELK1_19687146_ChIP-ChIP_HELA_Human1.76652003
50DCP1A_22483619_ChIP-Seq_HELA_Human1.73918866
51* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72257438
52ER_23166858_ChIP-Seq_MCF-7_Human1.70180975
53GABP_19822575_ChIP-Seq_HepG2_Human1.69807635
54TTF2_22483619_ChIP-Seq_HELA_Human1.65996884
55* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64910606
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63288772
57* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62052032
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60856914
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59670700
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58700999
61* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58655417
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58163205
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.54785629
64KDM5A_27292631_Chip-Seq_BREAST_Human1.54524075
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50950424
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50575504
67* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49086161
68CIITA_25753668_ChIP-Seq_RAJI_Human1.48161454
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46103624
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44959859
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43902440
72* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42838269
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.40982127
74STAT3_23295773_ChIP-Seq_U87_Human1.40781287
75MYC_22102868_ChIP-Seq_BL_Human1.40519845
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38819597
77CBP_20019798_ChIP-Seq_JUKART_Human1.38819597
78* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38571777
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37565386
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37367675
81* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35693630
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35628849
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33108689
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30424890
85EZH2_22144423_ChIP-Seq_EOC_Human1.30019124
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27115594
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.27112619
88SMAD4_21799915_ChIP-Seq_A2780_Human1.26806359
89TCF4_23295773_ChIP-Seq_U87_Human1.26596702
90* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25667687
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24928861
92TFEB_21752829_ChIP-Seq_HELA_Human1.24188438
93* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21907006
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20875934
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19935475
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19637259
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19632830
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.19038638
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.18092133
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17308720
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16963270
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16343478
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15330488
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15199666
105TP53_22573176_ChIP-Seq_HFKS_Human1.14296735
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14083284
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.13369806
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13238629
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13238629
110ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12664087
111AR_25329375_ChIP-Seq_VCAP_Human1.12534236
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10559862
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.09410804
114* BCAT_22108803_ChIP-Seq_LS180_Human1.09059993
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08113035
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07502834
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07313853
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07313853
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07313853
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07220715
121ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06853874
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06684599
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06053396
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05872219
125SOX2_19829295_ChIP-Seq_ESCs_Human1.05585972
126NANOG_19829295_ChIP-Seq_ESCs_Human1.05585972
127FOXA1_25329375_ChIP-Seq_VCAP_Human1.04883156
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04883156
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04492781
130KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03630602
131YY1_21170310_ChIP-Seq_MESCs_Mouse1.02643071
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02630190
133* TCF4_22108803_ChIP-Seq_LS180_Human1.02020745
134SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01929015
135* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00695626
136POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00198405
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.99626159
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98931314
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98672213
140* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97488351
141FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96331960
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.95846611
143RUNX2_22187159_ChIP-Seq_PCA_Human0.95172095
144MYC_18940864_ChIP-ChIP_HL60_Human0.94804310
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94717784
146FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94716265
147CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94564819
148FLI1_21867929_ChIP-Seq_TH2_Mouse0.94217497
149* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92291562
150SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90787352
151CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90667573
152PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90411591
153HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89671318
154SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89360699
155SRF_21415370_ChIP-Seq_HL-1_Mouse0.86732534
156FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86179529
157POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85533779
158NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.82336342
159HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81890006
160GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80634784
161NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79322442
162KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74002643
163CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.73613826
164SPI1_23547873_ChIP-Seq_NB4_Human0.73291812
165BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73075814
166NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.72982441
167NANOG_21062744_ChIP-ChIP_HESCs_Human0.72660202
168CHD1_26751641_Chip-Seq_LNCaP_Human0.68625879
169MYB_26560356_Chip-Seq_TH1_Human0.67557760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.06969226
2MP0010094_abnormal_chromosome_stability4.63542956
3MP0008057_abnormal_DNA_replication4.46364308
4MP0003693_abnormal_embryo_hatching4.40806201
5MP0003111_abnormal_nucleus_morphology3.99132121
6MP0004957_abnormal_blastocyst_morpholog3.74853529
7MP0003077_abnormal_cell_cycle3.64283230
8MP0008058_abnormal_DNA_repair3.52774453
9MP0006292_abnormal_olfactory_placode3.32660636
10MP0008007_abnormal_cellular_replicative2.69320050
11MP0003786_premature_aging2.66915412
12MP0003123_paternal_imprinting2.50701375
13MP0010352_gastrointestinal_tract_polyps2.44158276
14MP0002210_abnormal_sex_determination2.42688433
15MP0002102_abnormal_ear_morphology2.39509788
16MP0008995_early_reproductive_senescence2.36334567
17MP0000372_irregular_coat_pigmentation2.32963328
18MP0006072_abnormal_retinal_apoptosis2.31881067
19MP0010307_abnormal_tumor_latency2.31810911
20MP0001730_embryonic_growth_arrest2.24981469
21MP0008932_abnormal_embryonic_tissue2.22343007
22MP0001929_abnormal_gametogenesis2.21848800
23MP0000350_abnormal_cell_proliferation2.08529788
24MP0002396_abnormal_hematopoietic_system2.01711599
25MP0001145_abnormal_male_reproductive2.01026067
26MP0003195_calcinosis1.92445049
27MP0000427_abnormal_hair_cycle1.87002032
28MP0005551_abnormal_eye_electrophysiolog1.80872943
29MP0000653_abnormal_sex_gland1.78631955
30MP0000383_abnormal_hair_follicle1.76679182
31MP0005253_abnormal_eye_physiology1.73457053
32MP0002938_white_spotting1.71748175
33MP0004808_abnormal_hematopoietic_stem1.70009419
34MP0005380_embryogenesis_phenotype1.65431113
35MP0001672_abnormal_embryogenesis/_devel1.65431113
36MP0004147_increased_porphyrin_level1.64488518
37MP0003646_muscle_fatigue1.59696336
38MP0001697_abnormal_embryo_size1.59476314
39MP0005076_abnormal_cell_differentiation1.58046655
40MP0003950_abnormal_plasma_membrane1.56445138
41MP0003121_genomic_imprinting1.55941351
42MP0003698_abnormal_male_reproductive1.55493965
43MP0004197_abnormal_fetal_growth/weight/1.53486712
44MP0003984_embryonic_growth_retardation1.49585140
45MP0003890_abnormal_embryonic-extraembry1.48083738
46MP0002084_abnormal_developmental_patter1.46120369
47MP0002088_abnormal_embryonic_growth/wei1.45903709
48MP0003136_yellow_coat_color1.43569674
49MP0000631_abnormal_neuroendocrine_gland1.43561594
50MP0002638_abnormal_pupillary_reflex1.40855639
51MP0002085_abnormal_embryonic_tissue1.40545678
52MP0005646_abnormal_pituitary_gland1.40387142
53MP0002086_abnormal_extraembryonic_tissu1.39031920
54MP0002080_prenatal_lethality1.37182231
55MP0000313_abnormal_cell_death1.37049173
56MP0003763_abnormal_thymus_physiology1.33538584
57MP0005645_abnormal_hypothalamus_physiol1.31759511
58MP0005174_abnormal_tail_pigmentation1.30943500
59MP0008872_abnormal_physiological_respon1.29750957
60MP0002019_abnormal_tumor_incidence1.29167170
61MP0002234_abnormal_pharynx_morphology1.28106899
62MP0005410_abnormal_fertilization1.27924603
63MP0000569_abnormal_digit_pigmentation1.26578423
64MP0002095_abnormal_skin_pigmentation1.24508946
65MP0010678_abnormal_skin_adnexa1.24331705
66MP0000647_abnormal_sebaceous_gland1.22588581
67MP0003718_maternal_effect1.21125092
68MP0001119_abnormal_female_reproductive1.19962189
69MP0000490_abnormal_crypts_of1.19564851
70MP0004043_abnormal_pH_regulation1.19057706
71MP0004133_heterotaxia1.12839374
72MP0006276_abnormal_autonomic_nervous1.12514057
73MP0004142_abnormal_muscle_tone1.11695787
74MP0002928_abnormal_bile_duct1.06678120
75MP0002160_abnormal_reproductive_system1.06350091
76MP0005391_vision/eye_phenotype1.05262713
77MP0002837_dystrophic_cardiac_calcinosis1.05215289
78MP0000703_abnormal_thymus_morphology1.04735518
79MP0009046_muscle_twitch1.03885121
80MP0001293_anophthalmia1.02549105
81MP0002161_abnormal_fertility/fecundity1.00134397
82MP0002876_abnormal_thyroid_physiology0.98191758
83MP0005395_other_phenotype0.95845243
84MP0008789_abnormal_olfactory_epithelium0.94856050
85MP0002751_abnormal_autonomic_nervous0.93723695
86MP0001286_abnormal_eye_development0.93511103
87MP0002398_abnormal_bone_marrow0.91932510
88MP0002736_abnormal_nociception_after0.91466265
89MP0003567_abnormal_fetal_cardiomyocyte0.90254482
90MP0006035_abnormal_mitochondrial_morpho0.89785257
91MP0001915_intracranial_hemorrhage0.89764542
92MP0005195_abnormal_posterior_eye0.89317352
93MP0005187_abnormal_penis_morphology0.88721454
94MP0005397_hematopoietic_system_phenotyp0.88586852
95MP0001545_abnormal_hematopoietic_system0.88586852
96MP0005075_abnormal_melanosome_morpholog0.86787177
97MP0002163_abnormal_gland_morphology0.86718751
98MP0001919_abnormal_reproductive_system0.85579359
99MP0001485_abnormal_pinna_reflex0.85245105
100MP0001968_abnormal_touch/_nociception0.84505292
101MP0005084_abnormal_gallbladder_morpholo0.83273635
102MP0010386_abnormal_urinary_bladder0.82628020
103MP0002233_abnormal_nose_morphology0.82304220
104MP0004145_abnormal_muscle_electrophysio0.82155774
105MP0003787_abnormal_imprinting0.81455490
106MP0002722_abnormal_immune_system0.80634694
107MP0004885_abnormal_endolymph0.79880851
108MP0005621_abnormal_cell_physiology0.79861237
109MP0005171_absent_coat_pigmentation0.79219350
110MP0001324_abnormal_eye_pigmentation0.78065173
111MP0000689_abnormal_spleen_morphology0.77312387
112MP0001984_abnormal_olfaction0.77264866
113MP0005384_cellular_phenotype0.77253305
114MP0005389_reproductive_system_phenotype0.76301384
115MP0003705_abnormal_hypodermis_morpholog0.75871894
116MP0003937_abnormal_limbs/digits/tail_de0.75754396
117MP0003699_abnormal_female_reproductive0.75621782
118MP0009703_decreased_birth_body0.75461364
119MP0005023_abnormal_wound_healing0.74980133
120MP0001986_abnormal_taste_sensitivity0.73923121
121MP0009672_abnormal_birth_weight0.73836514
122MP0008875_abnormal_xenobiotic_pharmacok0.73441943
123MP0003115_abnormal_respiratory_system0.72296607
124MP0002132_abnormal_respiratory_system0.70789165
125MP0005379_endocrine/exocrine_gland_phen0.70411146
126MP0000015_abnormal_ear_pigmentation0.69392366
127MP0003252_abnormal_bile_duct0.69199113
128MP0008961_abnormal_basal_metabolism0.68772845
129MP0001529_abnormal_vocalization0.68468014
130MP0002653_abnormal_ependyma_morphology0.68149855
131MP0002006_tumorigenesis0.66645517
132MP0000371_diluted_coat_color0.66270967
133MP0003880_abnormal_central_pattern0.65972500
134MP0003566_abnormal_cell_adhesion0.65894305
135MP0003936_abnormal_reproductive_system0.65471663
136MP0009333_abnormal_splenocyte_physiolog0.65003042
137MP0003315_abnormal_perineum_morphology0.64317009
138MP0003119_abnormal_digestive_system0.63920372
139MP0000432_abnormal_head_morphology0.63875597
140MP0003011_delayed_dark_adaptation0.63602566
141MP0002166_altered_tumor_susceptibility0.63303483
142MP0003941_abnormal_skin_development0.63211212
143MP0010030_abnormal_orbit_morphology0.62971810
144MP0000358_abnormal_cell_content/0.62382612
145MP0002429_abnormal_blood_cell0.62204881
146MP0002405_respiratory_system_inflammati0.62126014
147MP0009053_abnormal_anal_canal0.61438632
148MP0000537_abnormal_urethra_morphology0.60738493
149MP0009697_abnormal_copulation0.60570737
150MP0002092_abnormal_eye_morphology0.58487511
151MP0000733_abnormal_muscle_development0.58425578
152MP0002075_abnormal_coat/hair_pigmentati0.58058501
153MP0006054_spinal_hemorrhage0.57663893
154MP0003448_altered_tumor_morphology0.56588613
155MP0000428_abnormal_craniofacial_morphol0.54972317
156MP0002111_abnormal_tail_morphology0.53858735
157MP0000716_abnormal_immune_system0.53776842
158MP0002697_abnormal_eye_size0.49343645
159MP0002925_abnormal_cardiovascular_devel0.49268678
160MP0003943_abnormal_hepatobiliary_system0.48448875
161MP0001186_pigmentation_phenotype0.47796850
162MP0002009_preneoplasia0.47774452

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.65927177
2Abnormal spermatogenesis (HP:0008669)4.53136815
3Azoospermia (HP:0000027)4.44052016
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.36815894
5Pancreatic cysts (HP:0001737)4.01401916
6Birth length less than 3rd percentile (HP:0003561)3.92326438
7Pancreatic fibrosis (HP:0100732)3.53461698
8Colon cancer (HP:0003003)3.53216129
9Abnormality of chromosome stability (HP:0003220)3.52610720
10Medulloblastoma (HP:0002885)3.43642027
11Molar tooth sign on MRI (HP:0002419)3.40734574
12Abnormality of midbrain morphology (HP:0002418)3.40734574
13Selective tooth agenesis (HP:0001592)3.37587140
1411 pairs of ribs (HP:0000878)3.36939219
15Reticulocytopenia (HP:0001896)3.32733226
16True hermaphroditism (HP:0010459)3.23337531
17Abnormality of the anterior horn cell (HP:0006802)3.19861060
18Degeneration of anterior horn cells (HP:0002398)3.19861060
19Ectopic kidney (HP:0000086)3.14141191
20Ependymoma (HP:0002888)3.08447440
21Impulsivity (HP:0100710)3.03502969
22Nephronophthisis (HP:0000090)3.02145529
23Abnormality of the preputium (HP:0100587)2.96566535
24Meckel diverticulum (HP:0002245)2.95647249
25Absent thumb (HP:0009777)2.93155813
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.86746923
27Chronic hepatic failure (HP:0100626)2.84244534
28Breast hypoplasia (HP:0003187)2.82946942
29Abnormality of the renal cortex (HP:0011035)2.80885092
30Abnormality of the ileum (HP:0001549)2.77371557
31Rhabdomyosarcoma (HP:0002859)2.74505137
32Abnormality of the renal medulla (HP:0100957)2.74325289
33Abnormality of the labia minora (HP:0012880)2.73696386
34Congenital stationary night blindness (HP:0007642)2.73529863
35Agnosia (HP:0010524)2.68577462
36Absent radius (HP:0003974)2.68420904
37Carpal bone hypoplasia (HP:0001498)2.63551533
38Abnormality of alanine metabolism (HP:0010916)2.61043561
39Hyperalaninemia (HP:0003348)2.61043561
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61043561
41Gonadotropin excess (HP:0000837)2.56397501
42Myelodysplasia (HP:0002863)2.55068294
43Type II lissencephaly (HP:0007260)2.54846968
44Prominent nose (HP:0000448)2.53450809
45Duplicated collecting system (HP:0000081)2.47417864
46Aplasia involving forearm bones (HP:0009822)2.45936691
47Absent forearm bone (HP:0003953)2.45936691
48Patellar aplasia (HP:0006443)2.39182202
49Supernumerary spleens (HP:0009799)2.39023756
50Small intestinal stenosis (HP:0012848)2.38691619
51Duodenal stenosis (HP:0100867)2.38691619
52Medial flaring of the eyebrow (HP:0010747)2.34249436
53Attenuation of retinal blood vessels (HP:0007843)2.30002978
54Spinal muscular atrophy (HP:0007269)2.29912601
55Volvulus (HP:0002580)2.29059968
56Sloping forehead (HP:0000340)2.28618323
57Glioma (HP:0009733)2.27271105
58Abnormality of the astrocytes (HP:0100707)2.26534343
59Astrocytoma (HP:0009592)2.26534343
60Missing ribs (HP:0000921)2.26475231
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.25427579
62Abnormality of the carotid arteries (HP:0005344)2.24081441
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.24061235
64Aplasia/Hypoplasia of the patella (HP:0006498)2.24021757
65Abnormal biliary tract physiology (HP:0012439)2.23758226
66Bile duct proliferation (HP:0001408)2.23758226
67Basal cell carcinoma (HP:0002671)2.23455803
68Tubular atrophy (HP:0000092)2.21728646
69Facial hemangioma (HP:0000329)2.19095403
70Abnormality of the pons (HP:0007361)2.18619159
71Neoplasm of the oral cavity (HP:0100649)2.18501760
72Deviation of the thumb (HP:0009603)2.18462407
73Cystic liver disease (HP:0006706)2.17048612
74Gaze-evoked nystagmus (HP:0000640)2.16101334
75Proximal placement of thumb (HP:0009623)2.15813498
76Abnormal number of incisors (HP:0011064)2.14994848
77Short thumb (HP:0009778)2.14319822
78Neoplasm of the pancreas (HP:0002894)2.13821096
79Oral leukoplakia (HP:0002745)2.12979049
80Oligodactyly (hands) (HP:0001180)2.12742733
81Neoplasm of striated muscle (HP:0009728)2.12558564
82Pendular nystagmus (HP:0012043)2.11719423
83Increased nuchal translucency (HP:0010880)2.10561002
84Renal cortical cysts (HP:0000803)2.10066474
85Fair hair (HP:0002286)2.09699569
86Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.07795546
87Short 4th metacarpal (HP:0010044)2.07795546
88Abnormality of DNA repair (HP:0003254)2.07300168
89Sclerocornea (HP:0000647)2.07163949
90Bone marrow hypocellularity (HP:0005528)2.06797446
91Abnormality of the renal collecting system (HP:0004742)2.06598531
92Squamous cell carcinoma (HP:0002860)2.05980834
93Small hand (HP:0200055)2.05564875
94Long eyelashes (HP:0000527)2.04307383
95Hypoplasia of the pons (HP:0012110)2.03954649
96Cerebellar dysplasia (HP:0007033)2.03470058
97Amaurosis fugax (HP:0100576)2.02066268
98Progressive inability to walk (HP:0002505)2.02023661
99Hyperventilation (HP:0002883)2.00993862
100Anencephaly (HP:0002323)1.99738014
101Abnormality of the fingertips (HP:0001211)1.99594371
102Facial cleft (HP:0002006)1.98487821
103Biliary tract neoplasm (HP:0100574)1.96309706
104Intestinal atresia (HP:0011100)1.96221646
105Cafe-au-lait spot (HP:0000957)1.95584554
106Dandy-Walker malformation (HP:0001305)1.94358003
107Rough bone trabeculation (HP:0100670)1.93217199
108Horseshoe kidney (HP:0000085)1.92295749
109Abnormal biliary tract morphology (HP:0012440)1.90739196
110Atrophy/Degeneration involving motor neurons (HP:0007373)1.90659201
111High pitched voice (HP:0001620)1.90357107
112Tubulointerstitial nephritis (HP:0001970)1.89984266
113Congenital, generalized hypertrichosis (HP:0004540)1.89643665
114Abnormality of the duodenum (HP:0002246)1.88621854
115Astigmatism (HP:0000483)1.87809499
116Nephroblastoma (Wilms tumor) (HP:0002667)1.87517353
117Abnormal lung lobation (HP:0002101)1.87472873
118Hypoplastic iliac wings (HP:0002866)1.87431974
119Acute myeloid leukemia (HP:0004808)1.86556793
120Premature graying of hair (HP:0002216)1.86297338
121Abolished electroretinogram (ERG) (HP:0000550)1.85904715
122Male infertility (HP:0003251)1.85620534
123Congenital hepatic fibrosis (HP:0002612)1.85392483
124Lissencephaly (HP:0001339)1.84989114
125Pulmonary fibrosis (HP:0002206)1.84600987
126Postaxial foot polydactyly (HP:0001830)1.84433553
127Abnormality of cochlea (HP:0000375)1.84417742
128Clubbing of toes (HP:0100760)1.83863107
129Urethral obstruction (HP:0000796)1.83833887
130Lipid accumulation in hepatocytes (HP:0006561)1.83413581
131Sandal gap (HP:0001852)1.83396742
132Preaxial hand polydactyly (HP:0001177)1.83325440
133Methylmalonic acidemia (HP:0002912)1.83066955
134Neoplasm of the adrenal cortex (HP:0100641)1.83038446
135Increased hepatocellular lipid droplets (HP:0006565)1.81450572
136Stomach cancer (HP:0012126)1.81243547
137Increased CSF lactate (HP:0002490)1.80857446
138Aplastic anemia (HP:0001915)1.80641085
139Abnormal drinking behavior (HP:0030082)1.79786537
140Polydipsia (HP:0001959)1.79786537
141Triphalangeal thumb (HP:0001199)1.79482005
142Pelvic girdle muscle weakness (HP:0003749)1.78172281
143Partial agenesis of the corpus callosum (HP:0001338)1.77958155
144Tongue fasciculations (HP:0001308)1.77613167
145Oligohydramnios (HP:0001562)1.76687563
146Hyperglycinemia (HP:0002154)1.76207446
147Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75847819
148Metaphyseal cupping (HP:0003021)1.75615573
149Short tibia (HP:0005736)1.75609022
150Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75028117
151Tracheoesophageal fistula (HP:0002575)1.74654327
152Papillary thyroid carcinoma (HP:0002895)1.74262279
153Inability to walk (HP:0002540)1.74191206
154Congenital primary aphakia (HP:0007707)1.74179499
155Embryonal renal neoplasm (HP:0011794)1.73938054
156Atresia of the external auditory canal (HP:0000413)1.73890924
157Fibular aplasia (HP:0002990)1.73718399
158Neoplasm of the colon (HP:0100273)1.73249046
159Furrowed tongue (HP:0000221)1.73021067
160Chorioretinal atrophy (HP:0000533)1.72884099
161Hypothermia (HP:0002045)1.72863067
162Pallor (HP:0000980)1.71693985
163Cutaneous melanoma (HP:0012056)1.70680748
164Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69027352
165Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69009626
166Aplasia/Hypoplasia of the fovea (HP:0008060)1.66370703
167Hypoplasia of the fovea (HP:0007750)1.66370703
168Protruding tongue (HP:0010808)1.66179547
169Gait imbalance (HP:0002141)1.64795556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.99051026
2FRK4.42589348
3WEE13.88172407
4CDK123.52494579
5ACVR1B3.51057780
6NEK23.08967908
7BUB12.93596184
8BMPR1B2.85953540
9TTK2.60977339
10EIF2AK12.55612158
11SRPK12.44969271
12PLK42.40242687
13BRSK22.34000139
14PLK12.08772113
15ATR2.06343271
16WNK41.90848435
17MAP4K21.89306631
18BRD41.85186559
19STK391.83865113
20ADRBK21.83687140
21WNK31.77156890
22PDK41.70286391
23PDK31.70286391
24TSSK61.66848375
25PASK1.66112815
26MST41.62886604
27CHEK21.61114040
28MAP3K41.59137540
29PLK31.59120739
30CHEK11.59040012
31AURKB1.58128018
32CDK71.56543662
33DYRK31.55220002
34OXSR11.54938681
35LMTK21.52519964
36TLK11.52423952
37ZAK1.51502081
38EIF2AK31.49698453
39NEK11.45698588
40MKNK11.45127798
41GRK11.44377633
42CDK41.41800026
43MKNK21.40796332
44ATM1.37293548
45STK101.37169587
46TAOK31.35916417
47STK31.34819346
48VRK11.34262782
49RPS6KA41.34011195
50TNIK1.29566114
51RPS6KB21.29262768
52PINK11.27292447
53MAP3K101.23493185
54SCYL21.22475973
55STK41.14871054
56TGFBR11.13456377
57PLK21.12327581
58BRSK11.07305702
59TAF11.05229217
60MELK1.05088640
61LATS11.04241494
62MAP3K81.00738074
63STK38L1.00522161
64CSNK1G11.00076294
65CDK20.96260317
66MAPK130.95034251
67PIM10.92192290
68INSRR0.90001022
69TRIM280.89587609
70AURKA0.89208626
71PDK20.88520557
72EEF2K0.86773139
73EPHA20.85518924
74MUSK0.85189436
75ERBB30.83030654
76STK160.80644380
77NME20.79699777
78TESK10.79366393
79JAK30.79229804
80PAK40.78863856
81CDK10.78586738
82CSNK1G30.73506841
83STK240.73338533
84CASK0.71949602
85CDK60.71114201
86CSNK1G20.71107109
87CAMKK20.70216168
88CSNK1A1L0.68853522
89ADRBK10.68315452
90NUAK10.68063823
91MAP2K70.67350234
92CDK90.66887431
93PRKCE0.64513024
94MTOR0.64176812
95MARK30.62046032
96TESK20.60857899
97CSNK2A20.60730067
98EIF2AK20.59639824
99MAP3K30.58890707
100CHUK0.58224835
101FLT30.57237684
102FGFR20.56445015
103VRK20.55483789
104RPS6KA50.50966159
105PRKDC0.50815378
106PBK0.49392618
107CCNB10.48188562
108ALK0.47945816
109CSNK2A10.47340411
110TRPM70.45824334
111MAP4K10.45707192
112ZAP700.44689384
113CDK80.43920851
114AKT30.41916788
115MAPKAPK50.41151548
116CAMK1G0.40455224
117DYRK20.40317845
118PAK10.38248629
119MET0.38229826
120PAK30.38138458
121MAPK140.37589307
122BCR0.36456614
123CSNK1D0.35185050
124PRKCG0.35141450
125PNCK0.34956055
126CAMK1D0.33282955
127MAP2K30.33254713
128MAPKAPK30.32820791
129TIE10.32412301
130FGFR10.32166911
131CSNK1E0.31932559
132CDK30.30181429
133RPS6KB10.29415619
134PRKG20.28438501
135NME10.28157352
136IKBKB0.27622866
137AKT10.27409185
138PKN10.27400593
139GSK3B0.27155724
140TXK0.27008101
141MAPK10.26387073
142TEC0.24018565
143PRKD30.23149905
144NLK0.21679202
145LATS20.20599343
146PKN20.19521453
147PRKCI0.19200344

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.29908672
2DNA replication_Homo sapiens_hsa030304.26747795
3Mismatch repair_Homo sapiens_hsa034304.00047200
4RNA transport_Homo sapiens_hsa030133.37540130
5Homologous recombination_Homo sapiens_hsa034403.19115306
6Spliceosome_Homo sapiens_hsa030403.05450714
7Cell cycle_Homo sapiens_hsa041102.94023575
8Fanconi anemia pathway_Homo sapiens_hsa034602.80769050
9Basal transcription factors_Homo sapiens_hsa030222.73362311
10RNA polymerase_Homo sapiens_hsa030202.71087800
11Nucleotide excision repair_Homo sapiens_hsa034202.69481150
12Base excision repair_Homo sapiens_hsa034102.64352797
13One carbon pool by folate_Homo sapiens_hsa006702.49116072
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41732877
15Non-homologous end-joining_Homo sapiens_hsa034502.37109881
16mRNA surveillance pathway_Homo sapiens_hsa030152.28250898
17Proteasome_Homo sapiens_hsa030502.27018838
18RNA degradation_Homo sapiens_hsa030182.10210133
19Ribosome_Homo sapiens_hsa030102.08785549
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03361670
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98137495
22Nitrogen metabolism_Homo sapiens_hsa009101.98014992
23Phototransduction_Homo sapiens_hsa047441.96556601
24Pyrimidine metabolism_Homo sapiens_hsa002401.94636468
25p53 signaling pathway_Homo sapiens_hsa041151.71507966
26Systemic lupus erythematosus_Homo sapiens_hsa053221.62275401
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59172577
28Butanoate metabolism_Homo sapiens_hsa006501.58441304
29Linoleic acid metabolism_Homo sapiens_hsa005911.57752562
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56120101
31Propanoate metabolism_Homo sapiens_hsa006401.51644292
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49142809
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47781612
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47462201
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44512552
36Herpes simplex infection_Homo sapiens_hsa051681.31539785
37Epstein-Barr virus infection_Homo sapiens_hsa051691.31074892
38Selenocompound metabolism_Homo sapiens_hsa004501.27006559
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26726767
40Oxidative phosphorylation_Homo sapiens_hsa001901.26141533
41Viral carcinogenesis_Homo sapiens_hsa052031.25696908
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25056538
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.24732062
44Antigen processing and presentation_Homo sapiens_hsa046121.24631783
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23297935
46Oocyte meiosis_Homo sapiens_hsa041141.18835680
47Olfactory transduction_Homo sapiens_hsa047401.14062848
48Purine metabolism_Homo sapiens_hsa002301.13402708
49Ether lipid metabolism_Homo sapiens_hsa005651.09405123
50Parkinsons disease_Homo sapiens_hsa050121.04630387
51Tryptophan metabolism_Homo sapiens_hsa003801.03892131
52HTLV-I infection_Homo sapiens_hsa051661.03401540
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01766443
54Caffeine metabolism_Homo sapiens_hsa002320.98708301
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95826245
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90976525
57MicroRNAs in cancer_Homo sapiens_hsa052060.90937673
58Huntingtons disease_Homo sapiens_hsa050160.89990858
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85851233
60Small cell lung cancer_Homo sapiens_hsa052220.82877842
61Taste transduction_Homo sapiens_hsa047420.79304211
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77671477
63Sulfur metabolism_Homo sapiens_hsa009200.76132777
64Nicotine addiction_Homo sapiens_hsa050330.75738922
65Steroid biosynthesis_Homo sapiens_hsa001000.74887017
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.73159780
67TGF-beta signaling pathway_Homo sapiens_hsa043500.71799160
68Circadian rhythm_Homo sapiens_hsa047100.70377389
69Peroxisome_Homo sapiens_hsa041460.69355299
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67367025
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67142397
72Measles_Homo sapiens_hsa051620.65953289
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63944671
74Influenza A_Homo sapiens_hsa051640.63085137
75Legionellosis_Homo sapiens_hsa051340.62858915
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59423023
77Thyroid cancer_Homo sapiens_hsa052160.58829678
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58783486
79Primary immunodeficiency_Homo sapiens_hsa053400.58771886
80Alcoholism_Homo sapiens_hsa050340.58336594
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.57208882
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.55248275
83Lysine degradation_Homo sapiens_hsa003100.55208206
84Metabolic pathways_Homo sapiens_hsa011000.54701953
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54249246
86Apoptosis_Homo sapiens_hsa042100.53746258
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52813289
88Hippo signaling pathway_Homo sapiens_hsa043900.52558283
89Alzheimers disease_Homo sapiens_hsa050100.52274620
90Vitamin B6 metabolism_Homo sapiens_hsa007500.51102057
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51083178
92Colorectal cancer_Homo sapiens_hsa052100.50968599
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.50780245
94ABC transporters_Homo sapiens_hsa020100.49413712
95Pentose phosphate pathway_Homo sapiens_hsa000300.48240257
96Retinol metabolism_Homo sapiens_hsa008300.48154876
97Renin-angiotensin system_Homo sapiens_hsa046140.48079847
98Adherens junction_Homo sapiens_hsa045200.48025037
99Hepatitis B_Homo sapiens_hsa051610.47934099
100Arachidonic acid metabolism_Homo sapiens_hsa005900.46682936
101Ovarian steroidogenesis_Homo sapiens_hsa049130.46580362
102Regulation of autophagy_Homo sapiens_hsa041400.46386529
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46256122
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44620503
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42494143
106Notch signaling pathway_Homo sapiens_hsa043300.41774687
107Pyruvate metabolism_Homo sapiens_hsa006200.40962383
108Morphine addiction_Homo sapiens_hsa050320.40687020
109Basal cell carcinoma_Homo sapiens_hsa052170.40201029
110Fatty acid biosynthesis_Homo sapiens_hsa000610.40065506
111T cell receptor signaling pathway_Homo sapiens_hsa046600.39094549
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.37401942
113Serotonergic synapse_Homo sapiens_hsa047260.37302606
114Chronic myeloid leukemia_Homo sapiens_hsa052200.37102563
115Prostate cancer_Homo sapiens_hsa052150.36475864
116Hematopoietic cell lineage_Homo sapiens_hsa046400.36178490
117Pathways in cancer_Homo sapiens_hsa052000.35880029
118Glycerolipid metabolism_Homo sapiens_hsa005610.35860591
119mTOR signaling pathway_Homo sapiens_hsa041500.35491106
120Allograft rejection_Homo sapiens_hsa053300.34696161
121Dorso-ventral axis formation_Homo sapiens_hsa043200.34102030
122Viral myocarditis_Homo sapiens_hsa054160.32791584
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31967786
124Chemical carcinogenesis_Homo sapiens_hsa052040.31845093
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.31266736
126Toxoplasmosis_Homo sapiens_hsa051450.31065779
127Biosynthesis of amino acids_Homo sapiens_hsa012300.30801028
128HIF-1 signaling pathway_Homo sapiens_hsa040660.30436001
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30304314
130Shigellosis_Homo sapiens_hsa051310.29751052
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28526459
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28355061
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28000811
134FoxO signaling pathway_Homo sapiens_hsa040680.26854472
135Acute myeloid leukemia_Homo sapiens_hsa052210.25693725
136N-Glycan biosynthesis_Homo sapiens_hsa005100.24681195
137Pancreatic cancer_Homo sapiens_hsa052120.24628503
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23989212
139Intestinal immune network for IgA production_Homo sapiens_hsa046720.23979542
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21440267
141Proteoglycans in cancer_Homo sapiens_hsa052050.21045194
142Cardiac muscle contraction_Homo sapiens_hsa042600.20799666
143beta-Alanine metabolism_Homo sapiens_hsa004100.20276585
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20076519
145Wnt signaling pathway_Homo sapiens_hsa043100.18806027
146Fatty acid degradation_Homo sapiens_hsa000710.17731479
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.17190225
148TNF signaling pathway_Homo sapiens_hsa046680.16979365
149Fat digestion and absorption_Homo sapiens_hsa049750.16576206
150Hedgehog signaling pathway_Homo sapiens_hsa043400.16544636
151ECM-receptor interaction_Homo sapiens_hsa045120.15540949
152Autoimmune thyroid disease_Homo sapiens_hsa053200.15538413
153Protein export_Homo sapiens_hsa030600.15304162
154Leishmaniasis_Homo sapiens_hsa051400.14972530
155Cyanoamino acid metabolism_Homo sapiens_hsa004600.14672930
156B cell receptor signaling pathway_Homo sapiens_hsa046620.12091886
157Type I diabetes mellitus_Homo sapiens_hsa049400.11940285
158Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11680430

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