SPATA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.97376630
2axonemal dynein complex assembly (GO:0070286)9.91919147
3binding of sperm to zona pellucida (GO:0007339)9.87315044
4cell-cell recognition (GO:0009988)9.83058366
5epithelial cilium movement (GO:0003351)9.59407082
6motile cilium assembly (GO:0044458)9.18881687
7spermatid development (GO:0007286)9.15808930
8reproduction (GO:0000003)9.01325240
9cilium movement (GO:0003341)8.00961898
10regulation of cilium movement (GO:0003352)7.97982159
11piRNA metabolic process (GO:0034587)7.31863333
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.23952624
13single fertilization (GO:0007338)7.17489484
14male meiosis (GO:0007140)6.84911840
15synaptonemal complex organization (GO:0070193)6.84353663
16sperm capacitation (GO:0048240)6.79743414
17synaptonemal complex assembly (GO:0007130)6.66535334
18negative regulation of inclusion body assembly (GO:0090084)6.46919366
19* spermatogenesis (GO:0007283)6.09942688
20* male gamete generation (GO:0048232)6.07655849
21fertilization (GO:0009566)6.06720828
22microtubule depolymerization (GO:0007019)6.03890399
23organic cation transport (GO:0015695)5.80502055
24* gamete generation (GO:0007276)5.58888262
25regulation of inclusion body assembly (GO:0090083)5.25781823
26germ cell development (GO:0007281)5.20344607
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.14552513
28ventricular system development (GO:0021591)5.10024425
29presynaptic membrane assembly (GO:0097105)4.87183525
30male meiosis I (GO:0007141)4.84110605
31chromosome organization involved in meiosis (GO:0070192)4.59539428
32chromosome condensation (GO:0030261)4.59205099
33regulation of microtubule-based movement (GO:0060632)4.51430101
34spermatid nucleus differentiation (GO:0007289)4.50563820
35cell recognition (GO:0008037)4.50399257
36DNA methylation involved in gamete generation (GO:0043046)4.48439633
37calcium ion-dependent exocytosis (GO:0017156)4.42474733
38* multicellular organismal reproductive process (GO:0048609)4.42243639
39DNA packaging (GO:0006323)4.39901488
40seminiferous tubule development (GO:0072520)4.39652429
41glycerol ether metabolic process (GO:0006662)4.35621051
42nonmotile primary cilium assembly (GO:0035058)4.26390000
43presynaptic membrane organization (GO:0097090)4.22193410
44microtubule severing (GO:0051013)4.19910732
45left/right pattern formation (GO:0060972)4.16765591
46meiotic nuclear division (GO:0007126)4.16587251
47ether metabolic process (GO:0018904)3.98892541
48left/right axis specification (GO:0070986)3.93785092
49meiosis I (GO:0007127)3.84539544
50genitalia morphogenesis (GO:0035112)3.81883482
51postsynaptic membrane organization (GO:0001941)3.78750770
52microtubule bundle formation (GO:0001578)3.72169795
53meiotic cell cycle (GO:0051321)3.64718447
54sexual reproduction (GO:0019953)3.63795586
55sequestering of actin monomers (GO:0042989)3.61570979
56limb development (GO:0060173)3.61263828
57appendage development (GO:0048736)3.61263828
58* multicellular organismal development (GO:0007275)3.58365822
59mechanosensory behavior (GO:0007638)3.52590977
60chaperone-mediated protein complex assembly (GO:0051131)3.52372453
61monoubiquitinated protein deubiquitination (GO:0035520)3.49815115
62single strand break repair (GO:0000012)3.46251693
63retinal rod cell development (GO:0046548)3.41323506
64mitotic sister chromatid cohesion (GO:0007064)3.37690680
65photoreceptor cell maintenance (GO:0045494)3.35745388
66tachykinin receptor signaling pathway (GO:0007217)3.31969541
67regulation of spindle checkpoint (GO:0090231)3.28637176
68limb bud formation (GO:0060174)3.21030233
69protein refolding (GO:0042026)3.16029178
70smoothened signaling pathway (GO:0007224)3.12502980
71protein polyglutamylation (GO:0018095)3.12234439
72neural tube formation (GO:0001841)3.08211497
73cell projection assembly (GO:0030031)3.05589738
74interferon-gamma secretion (GO:0072643)3.02477002
75response to pheromone (GO:0019236)3.00390205
76nucleus organization (GO:0006997)3.00377476
77establishment of protein localization to Golgi (GO:0072600)3.00307391
78nuclear pore complex assembly (GO:0051292)2.97714022
79gene silencing by RNA (GO:0031047)2.97002337
80protein K11-linked deubiquitination (GO:0035871)2.95541765
81auditory behavior (GO:0031223)2.95139696
82pyrimidine nucleobase catabolic process (GO:0006208)2.94337110
83otic vesicle formation (GO:0030916)2.93295102
84olfactory bulb development (GO:0021772)2.91505761
85microtubule polymerization or depolymerization (GO:0031109)2.86418672
86protein localization to cilium (GO:0061512)2.86379528
87C4-dicarboxylate transport (GO:0015740)2.85084449
88retinal ganglion cell axon guidance (GO:0031290)2.84993022
89meiotic cell cycle process (GO:1903046)2.82127507
90brain morphogenesis (GO:0048854)2.81465288
91protein targeting to Golgi (GO:0000042)2.80886629
92lateral ventricle development (GO:0021670)2.79051408
93neuron cell-cell adhesion (GO:0007158)2.78067892
94cerebral cortex radially oriented cell migration (GO:0021799)2.75954231
95amino-acid betaine transport (GO:0015838)2.72869743
96carnitine transport (GO:0015879)2.72869743
97intraciliary transport (GO:0042073)2.72281856
98cilium organization (GO:0044782)2.71930710
99nucleoside diphosphate phosphorylation (GO:0006165)2.71597241
100retinal cone cell development (GO:0046549)2.70407383
101regulation of collateral sprouting (GO:0048670)2.69467968
102positive regulation of macrophage activation (GO:0043032)2.68720263
103eye photoreceptor cell differentiation (GO:0001754)2.67037765
104photoreceptor cell differentiation (GO:0046530)2.67037765
105determination of left/right symmetry (GO:0007368)2.66607095
106glycolytic process (GO:0006096)2.65142678
107axoneme assembly (GO:0035082)2.64920748
108microtubule-based movement (GO:0007018)2.64903343
109centriole assembly (GO:0098534)2.64416103
110retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62716419
111spinal cord motor neuron differentiation (GO:0021522)2.61382668
112synapsis (GO:0007129)2.60067218
113cilium assembly (GO:0042384)2.59735645
114cilium morphogenesis (GO:0060271)2.59300137
115carnitine transmembrane transport (GO:1902603)2.58534938
116polyol catabolic process (GO:0046174)2.57697141
117vocalization behavior (GO:0071625)2.55868674
118regulation of centriole replication (GO:0046599)2.53937658
119determination of bilateral symmetry (GO:0009855)2.52290786
120detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52156408
121cellular component assembly involved in morphogenesis (GO:0010927)2.50746972
122gene silencing (GO:0016458)2.47594607
123cochlea development (GO:0090102)2.46299190
124establishment of nucleus localization (GO:0040023)2.46220183
125retina layer formation (GO:0010842)2.45429135
126protein localization to Golgi apparatus (GO:0034067)2.44835536
127regulation of cilium assembly (GO:1902017)2.44050682
128negative regulation of translation, ncRNA-mediated (GO:0040033)2.43787260
129regulation of translation, ncRNA-mediated (GO:0045974)2.43787260
130negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.43787260
131specification of symmetry (GO:0009799)2.43727825
132pore complex assembly (GO:0046931)2.43584547
133centriole replication (GO:0007099)2.42898075
134phenol-containing compound catabolic process (GO:0019336)2.42868228
135central nervous system neuron axonogenesis (GO:0021955)2.42294806
136RNA destabilization (GO:0050779)2.40210011
137neuronal action potential propagation (GO:0019227)2.40114686
138GTP biosynthetic process (GO:0006183)2.39651148
139G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.39093594
140negative regulation of cytosolic calcium ion concentration (GO:0051481)2.38534176
141protein localization to chromosome, centromeric region (GO:0071459)2.37761258
142central nervous system projection neuron axonogenesis (GO:0021952)2.37155372
143negative regulation of skeletal muscle tissue development (GO:0048642)2.36953379
144behavioral response to ethanol (GO:0048149)2.36764288
145DNA double-strand break processing (GO:0000729)2.36363588
146regulation of meiosis I (GO:0060631)2.36306983
147regulation of smoothened signaling pathway (GO:0008589)2.35463534
148alditol metabolic process (GO:0019400)2.35355960
149nucleobase catabolic process (GO:0046113)2.35309920
150photoreceptor cell development (GO:0042461)2.30820666
151regulation of timing of cell differentiation (GO:0048505)2.30752813
152protein localization to synapse (GO:0035418)2.27567313
153organelle assembly (GO:0070925)2.27336787
154axonal fasciculation (GO:0007413)2.27328899
155inner ear receptor stereocilium organization (GO:0060122)2.27187786
156glycosphingolipid biosynthetic process (GO:0006688)2.24287985
157cellular response to sterol (GO:0036315)2.23398070
158resolution of meiotic recombination intermediates (GO:0000712)2.22615829
159somite development (GO:0061053)2.22253955
160dorsal/ventral pattern formation (GO:0009953)2.21070670
161fusion of sperm to egg plasma membrane (GO:0007342)13.1972665
162sperm motility (GO:0030317)12.9501495
163cell wall macromolecule catabolic process (GO:0016998)11.7501221
164cell wall macromolecule metabolic process (GO:0044036)11.7501221
165acrosome reaction (GO:0007340)10.9675158
166sperm-egg recognition (GO:0035036)10.9038824
167acrosome assembly (GO:0001675)10.6705262
168cilium or flagellum-dependent cell motility (GO:0001539)10.5559990
169multicellular organism reproduction (GO:0032504)10.5490514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.00694350
2GBX2_23144817_ChIP-Seq_PC3_Human3.23751824
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.10208955
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.08387933
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.57322042
6* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56256528
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50946534
8FUS_26573619_Chip-Seq_HEK293_Human2.49055044
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.43053127
10* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.42237922
11EZH2_22144423_ChIP-Seq_EOC_Human2.41611779
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41021884
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40628728
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33261142
15TAF15_26573619_Chip-Seq_HEK293_Human2.29773464
16P300_19829295_ChIP-Seq_ESCs_Human2.28206270
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.26446097
18VDR_22108803_ChIP-Seq_LS180_Human2.15152189
19IGF1R_20145208_ChIP-Seq_DFB_Human2.14986865
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14667608
21* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.10231137
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03954694
23PIAS1_25552417_ChIP-Seq_VCAP_Human2.02782194
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.4236214
25* SMAD4_21799915_ChIP-Seq_A2780_Human1.99618020
26EWS_26573619_Chip-Seq_HEK293_Human1.98628347
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.98410824
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94167873
29GATA1_26923725_Chip-Seq_HPCs_Mouse1.83119925
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82451777
31ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80402050
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.79888048
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79562146
34* STAT3_23295773_ChIP-Seq_U87_Human1.78187503
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76419304
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.74755270
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.74128959
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.73784832
39FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72638455
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70998581
41ER_23166858_ChIP-Seq_MCF-7_Human1.70317840
42STAT1_17558387_ChIP-Seq_HELA_Human1.68903295
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.68625291
44TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.67249276
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66955128
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66275180
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64637811
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.61921530
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61113176
50BCAT_22108803_ChIP-Seq_LS180_Human1.57732363
51KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.57265469
52AR_21572438_ChIP-Seq_LNCaP_Human1.57155917
53AR_25329375_ChIP-Seq_VCAP_Human1.54810481
54* TCF4_23295773_ChIP-Seq_U87_Human1.52728762
55GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50958849
56ZNF274_21170338_ChIP-Seq_K562_Hela1.49887467
57SOX2_22085726_ChIP-Seq_NPCs_Mouse1.49710554
58MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42713303
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41383499
60* RUNX2_22187159_ChIP-Seq_PCA_Human1.39793421
61GATA3_21867929_ChIP-Seq_CD8_Mouse1.39625845
62TCF4_22108803_ChIP-Seq_LS180_Human1.38798356
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37237998
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36984027
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.36720251
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36401874
67CBP_20019798_ChIP-Seq_JUKART_Human1.36401874
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33465633
69FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33329512
70KDM2B_26808549_Chip-Seq_REH_Human1.29929369
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28940296
72LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28573939
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28328977
74KAP1_22055183_ChIP-Seq_ESCs_Mouse1.28270503
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.27822848
76IRF8_27001747_Chip-Seq_BMDM_Mouse1.27299607
77CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26817152
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26567750
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25853486
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24787065
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24524812
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24383561
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.21651388
84CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21166923
85RNF2_27304074_Chip-Seq_NSC_Mouse1.20646111
86P53_21459846_ChIP-Seq_SAOS-2_Human1.20566511
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.20305397
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19862963
89GF1_26923725_Chip-Seq_HPCs_Mouse1.19129116
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19068045
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18976622
92SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18588588
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18521060
94PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.18385483
95TP53_18474530_ChIP-ChIP_U2OS_Human1.17781789
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16931862
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16820196
98* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15868617
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.15605090
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15583241
101P53_22387025_ChIP-Seq_ESCs_Mouse1.15070842
102NANOG_19829295_ChIP-Seq_ESCs_Human1.14988656
103SOX2_19829295_ChIP-Seq_ESCs_Human1.14988656
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14934086
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.14295131
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12531607
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12530253
108TP53_16413492_ChIP-PET_HCT116_Human1.12498117
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.12466412
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.12340120
111MYB_26560356_Chip-Seq_TH2_Human1.12151627
112IRF8_21731497_ChIP-ChIP_J774_Mouse1.12030626
113ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11403036
114GATA3_21867929_ChIP-Seq_TH1_Mouse1.10792067
115* REST_21632747_ChIP-Seq_MESCs_Mouse1.10407423
116STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10387348
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09898349
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09145898
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08914085
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08587246
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.08517627
122POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07546783
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.06041199
124GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05789241
125CDX2_22108803_ChIP-Seq_LS180_Human1.05764022
126SMAD3_21741376_ChIP-Seq_ESCs_Human1.05723150
127SPI1_26923725_Chip-Seq_HPCs_Mouse1.05538862
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05499804
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04534101
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03960699
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03549129
132RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03507647
133* TBL1_22424771_ChIP-Seq_293T_Human1.02801867
134VDR_24787735_ChIP-Seq_THP-1_Human1.02699428
135PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02006947
136* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01923146
137DROSHA_22980978_ChIP-Seq_HELA_Human1.01433685
138AHR_22903824_ChIP-Seq_MCF-7_Human1.01140647
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00930931
140CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00519967
141FOXM1_23109430_ChIP-Seq_U2OS_Human1.00507498
142SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00424427
143P300_18555785_Chip-Seq_ESCs_Mouse1.00203317
144RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99129628
145EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98646102
146SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98064798
147EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97037433
148LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96632079
149ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95552609
150MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95395451
151IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92793210
152MYC_27129775_Chip-Seq_CORNEA_Mouse0.91929029
153* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91807091
154OCT4_18555785_Chip-Seq_ESCs_Mouse0.91750160
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91711223
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91711223
157RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91031940
158SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90847630
159IRF8_22096565_ChIP-ChIP_GC-B_Human0.90192989
160ESET_19884257_ChIP-Seq_ESCs_Mouse0.89980323
161ELF1_20517297_ChIP-Seq_JURKAT_Human0.89326744
162OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88908980
163SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88781842
164NANOG_18555785_Chip-Seq_ESCs_Mouse0.88359057
165FLI1_21867929_ChIP-Seq_CD8_Mouse0.88318786
166PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88296959
167LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88161218
168GF1B_26923725_Chip-Seq_HPCs_Mouse0.88053229
169RARA_24833708_ChIP-Seq_LIVER_Mouse0.85818202
170EZH2_27294783_Chip-Seq_NPCs_Mouse0.85814748
171JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84536806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.29786660
2MP0001929_abnormal_gametogenesis4.95524510
3MP0008877_abnormal_DNA_methylation3.73479351
4MP0002210_abnormal_sex_determination3.15330568
5MP0002161_abnormal_fertility/fecundity2.87652014
6MP0001145_abnormal_male_reproductive2.65969387
7MP0003136_yellow_coat_color2.56915347
8MP0002736_abnormal_nociception_after2.44738660
9MP0005670_abnormal_white_adipose2.35577907
10MP0000653_abnormal_sex_gland2.26180987
11MP0002653_abnormal_ependyma_morphology2.24913354
12MP0003880_abnormal_central_pattern2.13431957
13MP0005551_abnormal_eye_electrophysiolog2.12886217
14MP0005623_abnormal_meninges_morphology2.08659265
15MP0008789_abnormal_olfactory_epithelium2.01502542
16MP0000778_abnormal_nervous_system2.00593741
17MP0005410_abnormal_fertilization14.6384449
18MP0001968_abnormal_touch/_nociception1.99392515
19MP0002102_abnormal_ear_morphology1.98449597
20MP0001486_abnormal_startle_reflex1.95956192
21MP0004133_heterotaxia1.95490209
22MP0005253_abnormal_eye_physiology1.93636974
23MP0005171_absent_coat_pigmentation1.92203611
24MP0006292_abnormal_olfactory_placode1.86909142
25MP0002638_abnormal_pupillary_reflex1.80753757
26MP0001485_abnormal_pinna_reflex1.78527783
27MP0002938_white_spotting1.76913322
28MP0006072_abnormal_retinal_apoptosis1.72654776
29MP0002233_abnormal_nose_morphology1.72292035
30MP0004043_abnormal_pH_regulation1.57573634
31MP0005394_taste/olfaction_phenotype1.54592434
32MP0005499_abnormal_olfactory_system1.54592434
33MP0003195_calcinosis1.51837087
34MP0006276_abnormal_autonomic_nervous1.51374996
35MP0002282_abnormal_trachea_morphology1.50056470
36MP0000566_synostosis1.48394626
37MP0009278_abnormal_bone_marrow1.46179124
38MP0002734_abnormal_mechanical_nocicepti1.44726414
39MP0000383_abnormal_hair_follicle1.43319593
40MP0002735_abnormal_chemical_nociception1.40262285
41MP0003283_abnormal_digestive_organ1.40020100
42MP0002160_abnormal_reproductive_system1.39491961
43MP0003937_abnormal_limbs/digits/tail_de1.39423622
44MP0000049_abnormal_middle_ear1.39014846
45MP0005248_abnormal_Harderian_gland1.36429420
46MP0000631_abnormal_neuroendocrine_gland1.35865175
47MP0002272_abnormal_nervous_system1.34551652
48MP0000026_abnormal_inner_ear1.33405457
49MP0001529_abnormal_vocalization1.32808665
50MP0002557_abnormal_social/conspecific_i1.31993130
51MP0004885_abnormal_endolymph1.31029636
52MP0009745_abnormal_behavioral_response1.28898630
53MP0000372_irregular_coat_pigmentation1.28154373
54MP0003122_maternal_imprinting1.26200258
55MP0005391_vision/eye_phenotype1.25293617
56MP0002572_abnormal_emotion/affect_behav1.24933982
57MP0000955_abnormal_spinal_cord1.23601898
58MP0001545_abnormal_hematopoietic_system1.23009722
59MP0005397_hematopoietic_system_phenotyp1.23009722
60MP0009046_muscle_twitch1.20917363
61MP0000427_abnormal_hair_cycle1.19351486
62MP0001963_abnormal_hearing_physiology1.19179802
63MP0003787_abnormal_imprinting1.18786966
64MP0005195_abnormal_posterior_eye1.18734890
65MP0002822_catalepsy1.16423645
66MP0002752_abnormal_somatic_nervous1.15653016
67MP0002067_abnormal_sensory_capabilities1.15551463
68MP0003890_abnormal_embryonic-extraembry1.13498759
69MP0004142_abnormal_muscle_tone1.12196595
70MP0004808_abnormal_hematopoietic_stem1.11783301
71MP0003121_genomic_imprinting1.10248274
72MP0001299_abnormal_eye_distance/1.10164104
73MP0001970_abnormal_pain_threshold1.09573636
74MP0001286_abnormal_eye_development1.08511046
75MP0001835_abnormal_antigen_presentation1.07761845
76MP0003755_abnormal_palate_morphology1.07330296
77MP0004859_abnormal_synaptic_plasticity1.07182156
78MP0003635_abnormal_synaptic_transmissio1.06962905
79MP0002184_abnormal_innervation1.06509792
80MP0002405_respiratory_system_inflammati1.06459349
81MP0008875_abnormal_xenobiotic_pharmacok1.05454513
82MP0000569_abnormal_digit_pigmentation1.05043878
83MP0004233_abnormal_muscle_weight1.04981529
84MP0001501_abnormal_sleep_pattern1.02702541
85MP0000685_abnormal_immune_system1.02061987
86MP0002095_abnormal_skin_pigmentation1.01587759
87MP0005174_abnormal_tail_pigmentation1.00215152
88MP0002063_abnormal_learning/memory/cond1.00081361
89MP0002751_abnormal_autonomic_nervous0.99466290
90MP0002882_abnormal_neuron_morphology0.99420791
91MP0002234_abnormal_pharynx_morphology0.95123403
92MP0001188_hyperpigmentation0.94608916
93MP0003861_abnormal_nervous_system0.94449679
94MP0010307_abnormal_tumor_latency0.93765313
95MP0004270_analgesia0.93393116
96MP0008058_abnormal_DNA_repair0.93012694
97MP0003718_maternal_effect0.92428944
98MP0005423_abnormal_somatic_nervous0.92287091
99MP0001177_atelectasis0.88748539
100MP0003279_aneurysm0.88265472
101MP0000516_abnormal_urinary_system0.88052809
102MP0005367_renal/urinary_system_phenotyp0.88052809
103MP0010678_abnormal_skin_adnexa0.87941807
104MP0002090_abnormal_vision0.87300843
105MP0010094_abnormal_chromosome_stability0.87129626
106MP0002152_abnormal_brain_morphology0.86582707
107MP0002909_abnormal_adrenal_gland0.86432040
108MP0010386_abnormal_urinary_bladder0.86423995
109MP0010030_abnormal_orbit_morphology0.85380543
110MP0005646_abnormal_pituitary_gland0.85245904
111MP0002229_neurodegeneration0.84832782
112MP0002064_seizures0.83956415
113MP0006054_spinal_hemorrhage0.82124972
114MP0003300_gastrointestinal_ulcer0.81430243
115MP0008007_abnormal_cellular_replicative0.78494045
116MP0009785_altered_susceptibility_to0.75438680
117MP0005389_reproductive_system_phenotype0.73316273
118MP0003448_altered_tumor_morphology0.72272288
119MP0002928_abnormal_bile_duct0.71671455
120MP0006082_CNS_inflammation0.71037306
121MP0001765_abnormal_ion_homeostasis0.69894598
122MP0008438_abnormal_cutaneous_collagen0.69246202
123MP0008995_early_reproductive_senescence0.68543439
124MP0003115_abnormal_respiratory_system0.68363429
125MP0001293_anophthalmia0.66678415
126MP0005647_abnormal_sex_gland0.66616202
127MP0002452_abnormal_antigen_presenting0.66038295
128MP0005503_abnormal_tendon_morphology0.65592433
129MP0003646_muscle_fatigue0.64804826
130MP0002723_abnormal_immune_serum0.64163575
131MP0003045_fibrosis0.63582710
132MP0000733_abnormal_muscle_development0.63464239
133MP0003878_abnormal_ear_physiology0.62114503
134MP0005377_hearing/vestibular/ear_phenot0.62114503
135MP0008057_abnormal_DNA_replication0.59808019
136MP0003436_decreased_susceptibility_to0.59421281
137MP0001849_ear_inflammation0.59412168
138MP0003763_abnormal_thymus_physiology0.58983200
139MP0002398_abnormal_bone_marrow0.58981468
140MP0005025_abnormal_response_to0.58842478
141MP0001819_abnormal_immune_cell0.57746660
142MP0002420_abnormal_adaptive_immunity0.57713554
143MP0001915_intracranial_hemorrhage0.57314510
144MP0000858_altered_metastatic_potential0.57130527
145MP0001851_eye_inflammation0.57087825
146MP0002419_abnormal_innate_immunity0.57000425
147MP0000358_abnormal_cell_content/0.56576746
148MP0005000_abnormal_immune_tolerance0.56336985
149MP0002138_abnormal_hepatobiliary_system0.56066701
150MP0001873_stomach_inflammation0.55938404
151MP0001800_abnormal_humoral_immune0.55474777
152MP0005076_abnormal_cell_differentiation0.54622294
153MP0005671_abnormal_response_to0.54514638
154MP0003111_abnormal_nucleus_morphology0.54431598
155MP0002148_abnormal_hypersensitivity_rea0.54033774
156MP0005387_immune_system_phenotype0.53702976
157MP0001790_abnormal_immune_system0.53702976
158MP0003950_abnormal_plasma_membrane0.53326814
159MP0002166_altered_tumor_susceptibility0.52947541
160MP0009115_abnormal_fat_cell0.52223996
161MP0000703_abnormal_thymus_morphology0.51801803
162MP0003077_abnormal_cell_cycle0.49733018
163MP0005666_abnormal_adipose_tissue0.49562820
164MP0004947_skin_inflammation0.48609934
165MP0000716_abnormal_immune_system0.48258648
166MP0002006_tumorigenesis0.47740039
167MP0003786_premature_aging0.47491656
168MP0001984_abnormal_olfaction0.46483203
169MP0003091_abnormal_cell_migration0.46317835
170MP0001119_abnormal_female_reproductive0.45309569
171MP0003303_peritoneal_inflammation0.44587904
172MP0003943_abnormal_hepatobiliary_system0.43865397
173MP0001324_abnormal_eye_pigmentation0.43842792
174MP0001853_heart_inflammation0.43769274
175MP0002092_abnormal_eye_morphology0.41783722
176MP0002295_abnormal_pulmonary_circulatio0.41736998
177MP0005275_abnormal_skin_tensile0.41562061
178MP0000689_abnormal_spleen_morphology0.41436956
179MP0001879_abnormal_lymphatic_vessel0.40155733
180MP0000313_abnormal_cell_death0.39714206
181MP0000249_abnormal_blood_vessel0.39657157
182MP0003942_abnormal_urinary_system0.39639854
183MP0002429_abnormal_blood_cell0.39547773
184MP0002009_preneoplasia0.38335974
185MP0003724_increased_susceptibility_to0.38079503
186MP0000534_abnormal_ureter_morphology0.37915349

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.90457980
2Abnormal respiratory epithelium morphology (HP:0012253)8.70599838
3Abnormal respiratory motile cilium morphology (HP:0005938)8.70599838
4Rhinitis (HP:0012384)7.28315975
5Abnormal ciliary motility (HP:0012262)7.07012955
6Nasal polyposis (HP:0100582)7.03039204
7Chronic bronchitis (HP:0004469)6.86557628
8Infertility (HP:0000789)6.25142960
9Abnormality of the nasal mucosa (HP:0000433)5.96992265
10Bronchitis (HP:0012387)4.84849838
11Bronchiectasis (HP:0002110)4.68095007
12Chronic hepatic failure (HP:0100626)4.46724119
13Pancreatic cysts (HP:0001737)4.39673431
14Male infertility (HP:0003251)4.09608119
15Nephronophthisis (HP:0000090)4.05532186
16Occipital encephalocele (HP:0002085)3.87168106
17Recurrent bronchitis (HP:0002837)3.50377979
18Abnormal spermatogenesis (HP:0008669)3.38946598
19Recurrent sinusitis (HP:0011108)3.33811268
20Recurrent otitis media (HP:0000403)3.33130578
21Gait imbalance (HP:0002141)3.25677038
22Congenital primary aphakia (HP:0007707)3.22281945
23Abnormality of the renal medulla (HP:0100957)3.17682035
24Genital tract atresia (HP:0001827)3.09715485
25Vaginal atresia (HP:0000148)3.04876338
26Nephrogenic diabetes insipidus (HP:0009806)2.92283837
27Anencephaly (HP:0002323)2.85487528
28Abnormality of macular pigmentation (HP:0008002)2.81798444
29Tubulointerstitial nephritis (HP:0001970)2.78620981
30Sclerocornea (HP:0000647)2.71853715
31Tubular atrophy (HP:0000092)2.66449336
32Poor coordination (HP:0002370)2.51654541
33Abnormality of midbrain morphology (HP:0002418)2.45321063
34Molar tooth sign on MRI (HP:0002419)2.45321063
35Male pseudohermaphroditism (HP:0000037)2.44059070
36Impulsivity (HP:0100710)2.41344372
37Gonadotropin excess (HP:0000837)2.37980349
38Preaxial hand polydactyly (HP:0001177)2.33155047
39Tubulointerstitial abnormality (HP:0001969)2.29793594
40Intestinal atresia (HP:0011100)2.29761403
41Hyperventilation (HP:0002883)2.27108547
42Decreased central vision (HP:0007663)2.16540017
43Azoospermia (HP:0000027)2.14890759
44Focal motor seizures (HP:0011153)2.12736667
45Narrow forehead (HP:0000341)2.05996635
46Furrowed tongue (HP:0000221)2.03718180
47Anophthalmia (HP:0000528)2.01753531
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5620895
49Dynein arm defect of respiratory motile cilia (HP:0012255)12.4626495
50Absent/shortened dynein arms (HP:0200106)12.4626495
51Bifid tongue (HP:0010297)1.96742769
52Broad foot (HP:0001769)1.91360706
53Absent frontal sinuses (HP:0002688)1.91151944
54Renal hypoplasia (HP:0000089)1.90729271
55Supernumerary spleens (HP:0009799)1.88786027
56Medial flaring of the eyebrow (HP:0010747)1.87890149
57Abnormality of dentin (HP:0010299)1.87391798
58Optic neuritis (HP:0100653)1.86291039
59Retrobulbar optic neuritis (HP:0100654)1.86291039
60Abnormality of the labia minora (HP:0012880)1.85754863
61Postaxial foot polydactyly (HP:0001830)1.84192673
62Abolished electroretinogram (ERG) (HP:0000550)1.82631844
63Tubulointerstitial fibrosis (HP:0005576)1.81959391
64Stage 5 chronic kidney disease (HP:0003774)1.80635527
65Short ribs (HP:0000773)1.80011205
66Absent speech (HP:0001344)1.78995647
67Hemiparesis (HP:0001269)1.78264505
68Orchitis (HP:0100796)1.77223737
69Bell-shaped thorax (HP:0001591)1.76683001
70Specific learning disability (HP:0001328)1.76360175
71Chronic sinusitis (HP:0011109)1.74621465
72Volvulus (HP:0002580)1.73898597
73Multicystic kidney dysplasia (HP:0000003)1.73795594
74Intellectual disability, moderate (HP:0002342)1.73555296
75Fibular hypoplasia (HP:0003038)1.73349679
76Prominent nasal bridge (HP:0000426)1.73009764
77Gastrointestinal atresia (HP:0002589)1.72986632
78Oligodactyly (hands) (HP:0001180)1.72711798
79Heterotopia (HP:0002282)1.72245431
80Aganglionic megacolon (HP:0002251)1.71885006
81Colon cancer (HP:0003003)1.70703784
82Myositis (HP:0100614)1.70227256
83Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69961615
84Abnormal rod and cone electroretinograms (HP:0008323)1.69337881
85Congenital hepatic fibrosis (HP:0002612)1.69034773
86Abnormal biliary tract physiology (HP:0012439)1.67073429
87Bile duct proliferation (HP:0001408)1.67073429
88Cutaneous finger syndactyly (HP:0010554)1.64710793
89Abnormality of the dental root (HP:0006486)1.62490873
90Taurodontia (HP:0000679)1.62490873
91Abnormality of permanent molar morphology (HP:0011071)1.62490873
92Aplasia/Hypoplasia of the tibia (HP:0005772)1.61843857
93Astigmatism (HP:0000483)1.60608041
94Short nail (HP:0001799)1.60327097
95Retinitis pigmentosa (HP:0000510)1.58952569
96Hemorrhage of the eye (HP:0011885)1.58076167
97Bony spicule pigmentary retinopathy (HP:0007737)1.56924015
98Deformed sella turcica (HP:0002681)1.56327234
99Abnormality of the renal cortex (HP:0011035)1.55735974
100Short foot (HP:0001773)1.55542206
101Hip dysplasia (HP:0001385)1.55417728
102Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.54701494
103Attenuation of retinal blood vessels (HP:0007843)1.54620935
104Loss of speech (HP:0002371)1.53978721
105Optic nerve hypoplasia (HP:0000609)1.53955956
106Hyperglycinemia (HP:0002154)1.53928097
107Dandy-Walker malformation (HP:0001305)1.53547537
108Retinal dysplasia (HP:0007973)1.52095772
109Asymmetric septal hypertrophy (HP:0001670)1.52038573
110Spastic tetraparesis (HP:0001285)1.51905161
111Abnormality of the ischium (HP:0003174)1.51757458
112Abnormality of molar (HP:0011077)1.51751645
113Abnormality of molar morphology (HP:0011070)1.51751645
114Drooling (HP:0002307)1.50899602
115Septo-optic dysplasia (HP:0100842)1.50736074
116Dyschromatopsia (HP:0007641)1.50554651
117Renal dysplasia (HP:0000110)1.50173849
118Highly arched eyebrow (HP:0002553)1.48290471
119Choroideremia (HP:0001139)1.47985500
120Progressive cerebellar ataxia (HP:0002073)1.47424691
121Abnormality of the dental pulp (HP:0006479)1.47172467
122Split foot (HP:0001839)1.45981783
123Chorioretinal coloboma (HP:0000567)1.45825424
124Cystic liver disease (HP:0006706)1.45018366
125Facial cleft (HP:0002006)1.43651037
126Oculomotor apraxia (HP:0000657)1.41710397
127Abnormal drinking behavior (HP:0030082)1.39881769
128Polydipsia (HP:0001959)1.39881769
129Abnormality of renal excretion (HP:0011036)1.39769488
130Absent epiphyses (HP:0010577)1.39553841
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.39553841
132Easy fatigability (HP:0003388)1.39219681
133Microglossia (HP:0000171)1.38004704
134Broad distal phalanx of finger (HP:0009836)1.35625357
135Short thorax (HP:0010306)1.35214443
136Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.34617504
137Abnormal gallbladder physiology (HP:0012438)1.32989897
138Cholecystitis (HP:0001082)1.32989897
139Truncal obesity (HP:0001956)1.30682023
140Postaxial hand polydactyly (HP:0001162)1.29132148
141J-shaped sella turcica (HP:0002680)1.28358849
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.28070909
143Impaired proprioception (HP:0010831)1.27265411
144Constricted visual fields (HP:0001133)1.25316179
145Median cleft lip (HP:0000161)1.23862814
146Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.22879362
147Short femoral neck (HP:0100864)1.19538258
148Abnormality of the sella turcica (HP:0002679)1.18084117
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.16712727
150Osteolytic defects of the hand bones (HP:0009699)1.16712727
151Nephropathy (HP:0000112)1.15874203
152High pitched voice (HP:0001620)1.15705414
153Amyotrophic lateral sclerosis (HP:0007354)1.14329088
154Rhizomelia (HP:0008905)1.13694773
155Aplasia/Hypoplasia of the lens (HP:0008063)1.12858084
156Glucose intolerance (HP:0000833)1.12682048
157Pancreatic fibrosis (HP:0100732)1.12625027
158True hermaphroditism (HP:0010459)1.12388156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.68754867
2PDK37.68754867
3TESK16.19372020
4PDK25.29904366
5PRKD34.49947342
6FRK4.13233789
7ICK3.92641249
8TNIK2.86597623
9CASK2.86195750
10WNK32.69419651
11BMPR1B2.52137823
12MAP4K22.23509313
13MAP3K42.20613540
14NEK22.20412586
15PTK2B2.16653098
16MARK12.02680232
17MKNK21.92237172
18WNK41.87324122
19DYRK1B1.85053970
20MAPK131.77395751
21PLK21.73377187
22STK391.63300481
23BRD41.61619224
24INSRR1.59654493
25FGFR21.57152499
26ACVR1B1.56012497
27NUAK11.54984500
28ERBB31.49148457
29BCR1.41710654
30MKNK11.40882951
31PNCK1.38378615
32PINK11.35939373
33CSNK1G21.28432119
34STK381.26790624
35NTRK31.21289307
36EPHA41.21121876
37AKT31.19721519
38STK31.19252409
39NTRK21.18606284
40MAP2K71.10735775
41EIF2AK31.09409697
42PDK11.07968096
43EEF2K1.03083484
44IRAK10.99318482
45CSNK1G10.98158911
46MAP3K100.95264701
47CSNK1A1L0.92541246
48PRKCE0.92375153
49SGK20.88238653
50DYRK30.87686012
51PAK30.87672741
52DYRK20.87183134
53MAP4K10.84231539
54ADRBK20.83244859
55STK100.83224937
56OXSR10.80545744
57TESK20.79951406
58TYRO30.79416777
59CDK30.79256320
60GRK10.78666965
61PRKCG0.78211757
62MAPK150.77918653
63TRIM280.77433660
64CSNK1G30.76285867
65WNK10.75864660
66PBK0.75635156
67NLK0.72697648
68ZAP700.72663607
69ZAK0.70260820
70CDK120.69752818
71PASK0.68280046
72ERBB40.66597079
73STK160.65969447
74SGK4940.65776181
75SGK2230.65776181
76ERBB20.64740834
77TTK0.63583503
78PLK30.63063338
79PKN10.61975234
80CAMK1G0.60299278
81TXK0.59354552
82DYRK1A0.59270126
83PAK40.57989163
84TBK10.56755063
85PAK20.54937923
86EPHA30.54655658
87PDPK10.54627889
88RPS6KA40.54381628
89CAMK2A0.52904729
90PIM10.52807263
91CHEK20.52595416
92LMTK20.50727207
93MET0.50662748
94RIPK40.50171084
95STK110.48834582
96CDK60.48679577
97MAP2K40.48621571
98TGFBR20.48343880
99FER0.48142822
100CDC70.47869699
101PRKG10.46843556
102MAP3K20.46434269
103FGFR10.45571801
104EPHB10.43719242
105PAK10.43217582
106WEE10.42748359
107VRK10.42300157
108PLK40.41941514
109ATR0.41339637
110PRKACA0.40855363
111MTOR0.39842156
112ROCK10.39267967
113MST40.39229376
114CAMK10.39157566
115CHEK10.38587020
116CSK0.38011190
117MAP3K140.37980007
118PIM20.37674646
119CAMK40.37478129
120MAP2K60.36582107
121JAK30.36465815
122TYK20.36397187
123ATM0.36331597
124YES10.36227433
125TRIB30.36226028
126BRSK20.36068117
127PIK3CG0.35670711
128TIE10.35330664
129MARK30.34718632
130CSNK1A10.34630290
131DMPK0.34469006
132MINK10.34251126
133PRKCZ0.34201526
134CAMKK20.31772423
135STK38L0.31072254
136SGK10.31071795
137EPHB20.31016202
138RIPK10.30755255
139KDR0.29475176
140CHUK0.29185443
141PDGFRB0.28173425
142CSF1R0.26499380
143CLK10.25644204
144ERN10.24861509
145CCNB10.24786308
146MARK20.24138665
147PTK60.23883599
148KIT0.22492384
149PRKG20.21070722
150PRKCQ0.20516394
151TTN0.19310562
152FGFR30.18567875
153CDK40.17688269
154NEK90.17571010
155IRAK20.17553469
156LCK0.17331072
157JAK10.14668787
158IKBKE0.14442978
159EGFR0.13791121
160STK40.11513675
161NEK10.11296493
162LATS10.11267658
163PLK10.10940108
164MAPKAPK30.10755444
165IKBKB0.10660680
166LRRK20.10646244
167RPS6KB10.10624886
168BTK0.10589841
169NEK60.10513633
170ITK0.10438864
171HCK0.10331797
172RPS6KA10.09550857
173TEC0.09256186
174TGFBR10.08806782

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.15637642
2Fatty acid biosynthesis_Homo sapiens_hsa000613.81107086
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.60282840
4Nicotine addiction_Homo sapiens_hsa050332.78069441
5Antigen processing and presentation_Homo sapiens_hsa046122.47277299
6Butanoate metabolism_Homo sapiens_hsa006502.42973682
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28190862
8Pyruvate metabolism_Homo sapiens_hsa006202.20345658
9Dorso-ventral axis formation_Homo sapiens_hsa043202.14921770
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14626617
11Linoleic acid metabolism_Homo sapiens_hsa005912.13903991
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.12901747
13Basal transcription factors_Homo sapiens_hsa030222.11754642
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.07233234
15Glucagon signaling pathway_Homo sapiens_hsa049222.02356036
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99857137
17Vitamin B6 metabolism_Homo sapiens_hsa007501.93376436
18Phototransduction_Homo sapiens_hsa047441.90969688
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87710129
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.83026275
21Nitrogen metabolism_Homo sapiens_hsa009101.78521310
22Fanconi anemia pathway_Homo sapiens_hsa034601.78504583
23Legionellosis_Homo sapiens_hsa051341.76871908
24beta-Alanine metabolism_Homo sapiens_hsa004101.76519219
25Chemical carcinogenesis_Homo sapiens_hsa052041.75590402
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.72742892
27Histidine metabolism_Homo sapiens_hsa003401.71102696
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65073095
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64901688
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.57897776
31Selenocompound metabolism_Homo sapiens_hsa004501.57476469
32Protein export_Homo sapiens_hsa030601.54599935
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54436393
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51821057
35Caffeine metabolism_Homo sapiens_hsa002321.51513934
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50689956
37Taste transduction_Homo sapiens_hsa047421.50259005
38Olfactory transduction_Homo sapiens_hsa047401.49875881
39Measles_Homo sapiens_hsa051621.46853521
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45275816
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43430648
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41408568
43Tryptophan metabolism_Homo sapiens_hsa003801.38604937
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38018635
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37764152
46Oocyte meiosis_Homo sapiens_hsa041141.37559876
47Propanoate metabolism_Homo sapiens_hsa006401.37260840
48Basal cell carcinoma_Homo sapiens_hsa052171.37146847
49Pentose phosphate pathway_Homo sapiens_hsa000301.36182699
50Non-homologous end-joining_Homo sapiens_hsa034501.36020288
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33009082
52Glycerolipid metabolism_Homo sapiens_hsa005611.32165590
53Toxoplasmosis_Homo sapiens_hsa051451.29416286
54ABC transporters_Homo sapiens_hsa020101.29325961
55Glutamatergic synapse_Homo sapiens_hsa047241.29273324
56Morphine addiction_Homo sapiens_hsa050321.29083620
57Retinol metabolism_Homo sapiens_hsa008301.27482416
58Mineral absorption_Homo sapiens_hsa049781.25282126
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.24857689
60Circadian entrainment_Homo sapiens_hsa047131.24069516
61Peroxisome_Homo sapiens_hsa041461.21553486
62mRNA surveillance pathway_Homo sapiens_hsa030151.21441562
63PPAR signaling pathway_Homo sapiens_hsa033201.19469131
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19118435
65Fatty acid elongation_Homo sapiens_hsa000621.17897135
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14223080
67Circadian rhythm_Homo sapiens_hsa047101.13259478
68RNA transport_Homo sapiens_hsa030131.13245053
69GABAergic synapse_Homo sapiens_hsa047271.12370232
70Steroid biosynthesis_Homo sapiens_hsa001001.11893036
71B cell receptor signaling pathway_Homo sapiens_hsa046621.10840775
72Huntingtons disease_Homo sapiens_hsa050161.10605035
73Steroid hormone biosynthesis_Homo sapiens_hsa001401.08808905
74Cocaine addiction_Homo sapiens_hsa050301.07452521
75Serotonergic synapse_Homo sapiens_hsa047261.06254385
76Insulin secretion_Homo sapiens_hsa049111.02377522
77Salivary secretion_Homo sapiens_hsa049701.02185337
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01896369
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00860845
80Osteoclast differentiation_Homo sapiens_hsa043801.00682147
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00094764
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.99785789
83Salmonella infection_Homo sapiens_hsa051320.98330611
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.98197531
85Influenza A_Homo sapiens_hsa051640.95847580
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94904300
87Malaria_Homo sapiens_hsa051440.94206595
88Ether lipid metabolism_Homo sapiens_hsa005650.91345009
89T cell receptor signaling pathway_Homo sapiens_hsa046600.89321304
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.88886603
91Amphetamine addiction_Homo sapiens_hsa050310.88681919
92Tyrosine metabolism_Homo sapiens_hsa003500.88097338
93Dopaminergic synapse_Homo sapiens_hsa047280.87611122
94Herpes simplex infection_Homo sapiens_hsa051680.86892662
95Fructose and mannose metabolism_Homo sapiens_hsa000510.86662879
96Shigellosis_Homo sapiens_hsa051310.84372075
97Hedgehog signaling pathway_Homo sapiens_hsa043400.84227296
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83984599
99Axon guidance_Homo sapiens_hsa043600.83670209
100Endocytosis_Homo sapiens_hsa041440.82521109
101Hippo signaling pathway_Homo sapiens_hsa043900.80108398
102Regulation of autophagy_Homo sapiens_hsa041400.79798268
103Graft-versus-host disease_Homo sapiens_hsa053320.79651829
104Viral carcinogenesis_Homo sapiens_hsa052030.79346500
105cAMP signaling pathway_Homo sapiens_hsa040240.77278894
106Purine metabolism_Homo sapiens_hsa002300.77236942
107Primary immunodeficiency_Homo sapiens_hsa053400.77107987
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75251461
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.75086643
110Phenylalanine metabolism_Homo sapiens_hsa003600.72619396
111Systemic lupus erythematosus_Homo sapiens_hsa053220.71710857
112Wnt signaling pathway_Homo sapiens_hsa043100.71591075
113Viral myocarditis_Homo sapiens_hsa054160.70735369
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70691533
115Hematopoietic cell lineage_Homo sapiens_hsa046400.70327540
116Epstein-Barr virus infection_Homo sapiens_hsa051690.67397881
117Calcium signaling pathway_Homo sapiens_hsa040200.66424189
118Renin-angiotensin system_Homo sapiens_hsa046140.66132873
119Cell cycle_Homo sapiens_hsa041100.64846770
120Small cell lung cancer_Homo sapiens_hsa052220.64763107
121Protein digestion and absorption_Homo sapiens_hsa049740.64758065
122HTLV-I infection_Homo sapiens_hsa051660.64381120
123Arachidonic acid metabolism_Homo sapiens_hsa005900.64233568
124Sphingolipid metabolism_Homo sapiens_hsa006000.63304085
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63291164
126Leishmaniasis_Homo sapiens_hsa051400.63092814
127Long-term depression_Homo sapiens_hsa047300.62715296
128VEGF signaling pathway_Homo sapiens_hsa043700.61559494
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61380830
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60689274
131Tight junction_Homo sapiens_hsa045300.59947774
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.59837192
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59720858
134HIF-1 signaling pathway_Homo sapiens_hsa040660.59120190
135Adherens junction_Homo sapiens_hsa045200.58864970
136Estrogen signaling pathway_Homo sapiens_hsa049150.58843954
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.58512185
138Lysine degradation_Homo sapiens_hsa003100.58264982
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56560501
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55295826
141RNA polymerase_Homo sapiens_hsa030200.54402535
142Renin secretion_Homo sapiens_hsa049240.54283926
143TNF signaling pathway_Homo sapiens_hsa046680.54090891
144Fatty acid metabolism_Homo sapiens_hsa012120.54051081
145p53 signaling pathway_Homo sapiens_hsa041150.53425688
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52509867
147TGF-beta signaling pathway_Homo sapiens_hsa043500.51040611
148Gastric acid secretion_Homo sapiens_hsa049710.50261589
149Melanogenesis_Homo sapiens_hsa049160.50156563
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48978944
151Glutathione metabolism_Homo sapiens_hsa004800.48852168
152ECM-receptor interaction_Homo sapiens_hsa045120.48737427
153Allograft rejection_Homo sapiens_hsa053300.48671786
154Thyroid hormone synthesis_Homo sapiens_hsa049180.47048250
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.45863523
156AMPK signaling pathway_Homo sapiens_hsa041520.44625188
157Carbon metabolism_Homo sapiens_hsa012000.43687427
158Leukocyte transendothelial migration_Homo sapiens_hsa046700.43600037
159DNA replication_Homo sapiens_hsa030300.42403434
160Fatty acid degradation_Homo sapiens_hsa000710.41553907
161Arginine and proline metabolism_Homo sapiens_hsa003300.41533736
162Other glycan degradation_Homo sapiens_hsa005110.40870619
163Metabolic pathways_Homo sapiens_hsa011000.39555361
164Homologous recombination_Homo sapiens_hsa034400.39040305
165Fat digestion and absorption_Homo sapiens_hsa049750.38913875
166cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38872383
167Ovarian steroidogenesis_Homo sapiens_hsa049130.37708513
168RNA degradation_Homo sapiens_hsa030180.37265764
169Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36976451
170Cholinergic synapse_Homo sapiens_hsa047250.36894137
171Inositol phosphate metabolism_Homo sapiens_hsa005620.36479214
172NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35624353
173Focal adhesion_Homo sapiens_hsa045100.34789937
174Insulin resistance_Homo sapiens_hsa049310.34015104
175Rheumatoid arthritis_Homo sapiens_hsa053230.33621801
176Phagosome_Homo sapiens_hsa041450.33202497

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