SPATA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, originally isolated from testis, is also expressed in retina. Mutations in this gene are associated with Leber congenital amaurosis and juvenile retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)9.72413507
2cell wall macromolecule metabolic process (GO:0044036)9.72413507
3sperm motility (GO:0030317)9.69800038
4fusion of sperm to egg plasma membrane (GO:0007342)9.32610684
5acrosome reaction (GO:0007340)8.72831792
6acrosome assembly (GO:0001675)8.43562090
7epithelial cilium movement (GO:0003351)8.42141733
8cilium or flagellum-dependent cell motility (GO:0001539)8.28387820
9axonemal dynein complex assembly (GO:0070286)8.27392594
10sperm-egg recognition (GO:0035036)8.13828916
11multicellular organism reproduction (GO:0032504)8.08778008
12cilium movement (GO:0003341)7.41784949
13binding of sperm to zona pellucida (GO:0007339)7.40378694
14regulation of cilium movement (GO:0003352)7.32752620
15plasma membrane fusion (GO:0045026)7.31767043
16motile cilium assembly (GO:0044458)7.29096766
17cell-cell recognition (GO:0009988)7.23358409
18spermatid development (GO:0007286)7.02599903
19reproduction (GO:0000003)6.71725012
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.52197247
21male meiosis (GO:0007140)5.84454501
22microtubule nucleation (GO:0007020)5.79826368
23microtubule depolymerization (GO:0007019)5.74554263
24homocysteine metabolic process (GO:0050667)5.67634712
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.64714367
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.64714367
27single fertilization (GO:0007338)5.63692872
28sperm capacitation (GO:0048240)5.52411331
29sulfur amino acid catabolic process (GO:0000098)5.40567819
30piRNA metabolic process (GO:0034587)5.38951086
31synaptonemal complex organization (GO:0070193)5.32082854
32calcium ion-dependent exocytosis (GO:0017156)5.29075162
33cysteine metabolic process (GO:0006534)5.25657837
34synaptonemal complex assembly (GO:0007130)5.03916561
35regulation of plasminogen activation (GO:0010755)4.91648281
36negative regulation of inclusion body assembly (GO:0090084)4.90998909
37adenosine metabolic process (GO:0046085)4.79971857
38epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.78133373
39fertilization (GO:0009566)4.68427914
40protein localization to cilium (GO:0061512)4.64640974
41spermatogenesis (GO:0007283)4.60778384
42male gamete generation (GO:0048232)4.59347304
43ventricular system development (GO:0021591)4.58307333
44inner ear receptor cell development (GO:0060119)4.57842147
45spermatid nucleus differentiation (GO:0007289)4.41682347
46regulation of microtubule-based movement (GO:0060632)4.33873847
47gamete generation (GO:0007276)4.27189990
48folic acid-containing compound biosynthetic process (GO:0009396)4.26220412
49axoneme assembly (GO:0035082)4.20229082
50microtubule severing (GO:0051013)4.20179442
51regulation of inclusion body assembly (GO:0090083)4.14425607
52intraciliary transport (GO:0042073)4.10772397
53cochlea development (GO:0090102)4.09452130
54platelet dense granule organization (GO:0060155)4.08894073
55cell recognition (GO:0008037)4.08586546
56primary amino compound metabolic process (GO:1901160)4.00503399
57protein polyglutamylation (GO:0018095)3.98236230
58germ cell development (GO:0007281)3.91632744
59white fat cell differentiation (GO:0050872)3.90400678
60protein-cofactor linkage (GO:0018065)3.90238922
61cellular process involved in reproduction in multicellular organism (GO:0022412)3.85486264
62negative regulation of DNA biosynthetic process (GO:2000279)3.84152832
63single strand break repair (GO:0000012)3.82104735
64DNA methylation involved in gamete generation (GO:0043046)3.79145206
65behavioral fear response (GO:0001662)3.77567117
66behavioral defense response (GO:0002209)3.77567117
67behavioral response to nicotine (GO:0035095)3.77054152
68cilium organization (GO:0044782)3.73980394
69organic cation transport (GO:0015695)3.70433139
70cilium assembly (GO:0042384)3.70093349
71chromosome organization involved in meiosis (GO:0070192)3.64693284
72male meiosis I (GO:0007141)3.61512934
73purine nucleotide salvage (GO:0032261)3.48232047
74GTP biosynthetic process (GO:0006183)3.47931598
75protein-chromophore linkage (GO:0018298)3.44722176
76cartilage morphogenesis (GO:0060536)3.43152411
77nucleoside diphosphate phosphorylation (GO:0006165)3.40729279
78innervation (GO:0060384)3.39293463
79cilium morphogenesis (GO:0060271)3.38033962
80protein K11-linked deubiquitination (GO:0035871)3.37808072
81pteridine-containing compound biosynthetic process (GO:0042559)3.36432465
82fear response (GO:0042596)3.34731345
83multicellular organismal reproductive process (GO:0048609)3.30804363
84microtubule polymerization or depolymerization (GO:0031109)3.29491433
85meiotic nuclear division (GO:0007126)3.26285364
86alternative mRNA splicing, via spliceosome (GO:0000380)3.25559179
87positive regulation of endothelial cell differentiation (GO:0045603)3.24135288
88cellular component assembly involved in morphogenesis (GO:0010927)3.23949888
89left/right pattern formation (GO:0060972)3.21405990
90regulation of gonadotropin secretion (GO:0032276)3.21369173
91nucleoside transmembrane transport (GO:1901642)3.21213968
92negative regulation of Ras GTPase activity (GO:0034261)3.21006436
93mitochondrial RNA metabolic process (GO:0000959)3.19302130
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15217406
95mitochondrial respiratory chain complex I assembly (GO:0032981)3.15217406
96NADH dehydrogenase complex assembly (GO:0010257)3.15217406
97positive regulation of oligodendrocyte differentiation (GO:0048714)3.12636970
98postsynaptic membrane organization (GO:0001941)3.07064684
99indole-containing compound catabolic process (GO:0042436)3.05237228
100indolalkylamine catabolic process (GO:0046218)3.05237228
101tryptophan catabolic process (GO:0006569)3.05237228
102rRNA methylation (GO:0031167)3.04943866
103L-serine metabolic process (GO:0006563)3.04305360
104negative regulation of keratinocyte proliferation (GO:0010839)3.03308299
105microtubule-based movement (GO:0007018)3.02346122
106serine family amino acid catabolic process (GO:0009071)3.00350986
107regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.98888433
108preassembly of GPI anchor in ER membrane (GO:0016254)2.98641155
109regulation of spindle checkpoint (GO:0090231)2.96698384
110response to pheromone (GO:0019236)2.95557395
111UTP biosynthetic process (GO:0006228)2.94878911
112seminiferous tubule development (GO:0072520)2.90862881
113meiosis I (GO:0007127)2.90845354
114polyol catabolic process (GO:0046174)2.90597912
115calcium ion import (GO:0070509)2.89519127
116histone H4-K12 acetylation (GO:0043983)2.89450461
117lactate metabolic process (GO:0006089)2.87763392
118glycerol ether metabolic process (GO:0006662)2.87530865
119protein localization to synapse (GO:0035418)2.86943682
120centriole assembly (GO:0098534)2.85389637
121guanosine-containing compound biosynthetic process (GO:1901070)2.83328951
122urinary tract smooth muscle contraction (GO:0014848)2.81548567
123membrane depolarization during action potential (GO:0086010)2.78340804
124pyrimidine nucleobase catabolic process (GO:0006208)2.78131178
125protein refolding (GO:0042026)2.74775883
126phosphatidylglycerol biosynthetic process (GO:0006655)2.72160938
127ether metabolic process (GO:0018904)2.72153220
128response to lipoprotein particle (GO:0055094)2.72062073
129desmosome organization (GO:0002934)2.71582195
130gamma-aminobutyric acid signaling pathway (GO:0007214)2.70993864
131ATP hydrolysis coupled proton transport (GO:0015991)2.68436647
132energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.68436647
133meiotic cell cycle (GO:0051321)2.68388817
134galactose catabolic process (GO:0019388)2.68388129
135multicellular organismal development (GO:0007275)2.67393357
136positive regulation of meiosis (GO:0045836)2.67035777
137indole-containing compound metabolic process (GO:0042430)2.65491503
138limb bud formation (GO:0060174)2.64302141
139sulfur amino acid biosynthetic process (GO:0000097)2.64002618
140heme transport (GO:0015886)2.63434750
141neuron cell-cell adhesion (GO:0007158)2.61021407
142kynurenine metabolic process (GO:0070189)2.60749892
143monoubiquitinated protein deubiquitination (GO:0035520)2.59644442
144protein complex biogenesis (GO:0070271)2.59190306
145gamma-aminobutyric acid transport (GO:0015812)2.59132826
146regulation of sequestering of triglyceride (GO:0010889)2.57792362
147centriole replication (GO:0007099)2.57594100
148GPI anchor metabolic process (GO:0006505)2.56094264
149galactose metabolic process (GO:0006012)2.54429340
150indolalkylamine metabolic process (GO:0006586)2.53736162
151serine family amino acid biosynthetic process (GO:0009070)2.53637536
152adult feeding behavior (GO:0008343)2.53436596
153negative regulation of catenin import into nucleus (GO:0035414)2.52583069
154presynaptic membrane organization (GO:0097090)2.52453804
155synapsis (GO:0007129)2.50144712
156startle response (GO:0001964)2.50111594
157tryptophan metabolic process (GO:0006568)2.50089667
158regulation of meiosis I (GO:0060631)2.49346205
159regulation of endothelial cell differentiation (GO:0045601)2.48489818
160rRNA modification (GO:0000154)2.48242203
161positive regulation of meiotic cell cycle (GO:0051446)2.46813697
162tRNA modification (GO:0006400)2.45479510
163neural tube formation (GO:0001841)2.43552810
164nucleobase catabolic process (GO:0046113)2.43186485
165synaptic vesicle exocytosis (GO:0016079)2.42796348
166positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.42531434
167regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.41862771
168regulation of protein kinase A signaling (GO:0010738)2.39452161
169UTP metabolic process (GO:0046051)2.38835665
170chromosome condensation (GO:0030261)2.38103523
171microtubule bundle formation (GO:0001578)2.37610469
172DNA packaging (GO:0006323)2.36675336
173left/right axis specification (GO:0070986)2.35065129
174meiotic cell cycle process (GO:1903046)2.34487049
175regulation of mitotic spindle checkpoint (GO:1903504)2.34431179
176regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.34431179
177presynaptic membrane assembly (GO:0097105)2.33711000
178nonmotile primary cilium assembly (GO:0035058)2.32110931
179glycolytic process (GO:0006096)2.30079044

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.40985863
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.08576969
3EZH2_22144423_ChIP-Seq_EOC_Human4.83189686
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.87205005
5GBX2_23144817_ChIP-Seq_PC3_Human3.06739738
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90129712
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56302914
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53567856
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.48873165
10TAF15_26573619_Chip-Seq_HEK293_Human2.35574412
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32479996
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.30824981
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18662419
14VDR_22108803_ChIP-Seq_LS180_Human2.18223046
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17579982
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13325865
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.11712995
18REST_21632747_ChIP-Seq_MESCs_Mouse2.11383840
19FUS_26573619_Chip-Seq_HEK293_Human1.99559980
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98710443
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94359232
22EWS_26573619_Chip-Seq_HEK293_Human1.82636221
23BCAT_22108803_ChIP-Seq_LS180_Human1.78679434
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75775655
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.71510687
26TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68873949
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.68008136
28RNF2_27304074_Chip-Seq_NSC_Mouse1.66267310
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65652696
30ZNF274_21170338_ChIP-Seq_K562_Hela1.64994487
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.63052586
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62725397
33* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62543337
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.61728969
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61243660
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61186561
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.60700494
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.60389345
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59816268
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55995533
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54187157
42TP53_22573176_ChIP-Seq_HFKS_Human1.53610991
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52730365
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.52589341
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.51443492
46SMAD4_21799915_ChIP-Seq_A2780_Human1.50456363
47RUNX2_22187159_ChIP-Seq_PCA_Human1.48163732
48P53_22387025_ChIP-Seq_ESCs_Mouse1.47029318
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45524565
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45317288
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43583123
52CMYC_18555785_Chip-Seq_ESCs_Mouse1.43078134
53CDX2_22108803_ChIP-Seq_LS180_Human1.42160657
54* P300_19829295_ChIP-Seq_ESCs_Human1.41387527
55MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40244199
56KDM2B_26808549_Chip-Seq_REH_Human1.39860176
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39689127
58TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.38626467
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37593112
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37479489
61SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36397427
62P300_18555785_Chip-Seq_ESCs_Mouse1.36354869
63STAT3_18555785_Chip-Seq_ESCs_Mouse1.35245374
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35129831
65EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34200025
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.32593856
67TCF4_22108803_ChIP-Seq_LS180_Human1.31568878
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.30155690
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29742503
70SOX2_19829295_ChIP-Seq_ESCs_Human1.28500641
71NANOG_19829295_ChIP-Seq_ESCs_Human1.28500641
72SOX9_26525672_Chip-Seq_HEART_Mouse1.28258640
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27171583
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27171583
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.26495955
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26442906
77OCT4_18555785_Chip-Seq_ESCs_Mouse1.25940769
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25805467
79CBP_20019798_ChIP-Seq_JUKART_Human1.25805467
80ER_23166858_ChIP-Seq_MCF-7_Human1.25154388
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24625624
82* REST_18959480_ChIP-ChIP_MESCs_Mouse1.24383372
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23505447
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.23465214
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.23429384
86TCF4_23295773_ChIP-Seq_U87_Human1.23032104
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22074752
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21612601
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21350888
90RUNX1_27457419_Chip-Seq_LIVER_Mouse1.21099297
91KLF4_18555785_Chip-Seq_ESCs_Mouse1.20987939
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.20793744
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20342676
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19858603
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.18548395
96EZH2_27304074_Chip-Seq_ESCs_Mouse1.17977874
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17961705
98NCOR_22424771_ChIP-Seq_293T_Human1.17621517
99KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16786440
100* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16400196
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.14213361
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13735317
103CTCF_18555785_Chip-Seq_ESCs_Mouse1.12516194
104JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12437888
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11863836
106EED_16625203_ChIP-ChIP_MESCs_Mouse1.11785869
107ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11638388
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10558484
109STAT3_23295773_ChIP-Seq_U87_Human1.10376135
110JUN_21703547_ChIP-Seq_K562_Human1.09712411
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09643831
112SOX2_21211035_ChIP-Seq_LN229_Gbm1.08967210
113ELK4_26923725_Chip-Seq_MESODERM_Mouse1.08205035
114PU1_27457419_Chip-Seq_LIVER_Mouse1.07738738
115ZFX_18555785_Chip-Seq_ESCs_Mouse1.07483395
116AR_25329375_ChIP-Seq_VCAP_Human1.07161703
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.07072652
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06751869
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06335479
120SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06197117
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06188691
122STAT1_17558387_ChIP-Seq_HELA_Human1.05357627
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05208179
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04709395
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02646185
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02531698
127IGF1R_20145208_ChIP-Seq_DFB_Human1.00623306
128SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00188171
129* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.00180169
130OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00015828
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99533204
132EZH2_27294783_Chip-Seq_ESCs_Mouse0.98391527
133SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97362595
134GABP_17652178_ChIP-ChIP_JURKAT_Human0.96934257
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96699906
136ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95881718
137* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94991883
138SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94029477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.13684092
2MP0003698_abnormal_male_reproductive3.90228151
3MP0008877_abnormal_DNA_methylation3.51425652
4MP0001929_abnormal_gametogenesis3.43997089
5MP0002938_white_spotting3.19497618
6MP0003880_abnormal_central_pattern3.03873249
7MP0004859_abnormal_synaptic_plasticity2.65245128
8MP0004885_abnormal_endolymph2.64744846
9MP0001984_abnormal_olfaction2.64390708
10MP0009046_muscle_twitch2.63383792
11MP0004147_increased_porphyrin_level2.33223428
12MP0002210_abnormal_sex_determination2.30584093
13MP0005670_abnormal_white_adipose2.23977330
14MP0003635_abnormal_synaptic_transmissio2.20381815
15MP0005360_urolithiasis2.20354465
16MP0005423_abnormal_somatic_nervous2.14777523
17MP0002161_abnormal_fertility/fecundity2.13897292
18MP0003787_abnormal_imprinting2.12265650
19MP0001968_abnormal_touch/_nociception2.05406030
20MP0002736_abnormal_nociception_after2.04035809
21MP0009745_abnormal_behavioral_response1.94278817
22MP0001145_abnormal_male_reproductive1.91834236
23MP0002063_abnormal_learning/memory/cond1.89897174
24MP0004270_analgesia1.89742363
25MP0005646_abnormal_pituitary_gland1.83638242
26MP0002572_abnormal_emotion/affect_behav1.80097743
27MP0010386_abnormal_urinary_bladder1.79216138
28MP0002102_abnormal_ear_morphology1.77601707
29MP0002064_seizures1.77588791
30MP0002272_abnormal_nervous_system1.75753890
31MP0002735_abnormal_chemical_nociception1.74561158
32MP0000013_abnormal_adipose_tissue1.73714174
33MP0000653_abnormal_sex_gland1.71726784
34MP0005551_abnormal_eye_electrophysiolog1.71410007
35MP0002734_abnormal_mechanical_nocicepti1.69164893
36MP0001986_abnormal_taste_sensitivity1.65278920
37MP0000516_abnormal_urinary_system1.64935641
38MP0005367_renal/urinary_system_phenotyp1.64935641
39MP0002653_abnormal_ependyma_morphology1.62906391
40MP0001529_abnormal_vocalization1.57732665
41MP0002095_abnormal_skin_pigmentation1.54920758
42MP0006276_abnormal_autonomic_nervous1.53719957
43MP0001486_abnormal_startle_reflex1.53157652
44MP0008872_abnormal_physiological_respon1.51058657
45MP0001501_abnormal_sleep_pattern1.50891178
46MP0006292_abnormal_olfactory_placode1.50744624
47MP0002234_abnormal_pharynx_morphology1.44676463
48MP0001440_abnormal_grooming_behavior1.43166613
49MP0002067_abnormal_sensory_capabilities1.40317652
50MP0002160_abnormal_reproductive_system1.39603302
51MP0003183_abnormal_peptide_metabolism1.36634767
52MP0006072_abnormal_retinal_apoptosis1.33315782
53MP0008058_abnormal_DNA_repair1.31256392
54MP0000647_abnormal_sebaceous_gland1.27308602
55MP0005623_abnormal_meninges_morphology1.25415943
56MP0001502_abnormal_circadian_rhythm1.22200669
57MP0002557_abnormal_social/conspecific_i1.22165429
58MP0004043_abnormal_pH_regulation1.21539897
59MP0001188_hyperpigmentation1.21251988
60MP0002184_abnormal_innervation1.21121319
61MP0000778_abnormal_nervous_system1.19992968
62MP0001764_abnormal_homeostasis1.19571432
63MP0005248_abnormal_Harderian_gland1.19092003
64MP0005253_abnormal_eye_physiology1.19055222
65MP0003879_abnormal_hair_cell1.17512501
66MP0000534_abnormal_ureter_morphology1.15166691
67MP0008789_abnormal_olfactory_epithelium1.10706661
68MP0000372_irregular_coat_pigmentation1.10641602
69MP0004142_abnormal_muscle_tone1.10635471
70MP0005332_abnormal_amino_acid1.10277795
71MP0005171_absent_coat_pigmentation1.08480582
72MP0002822_catalepsy1.08243337
73MP0001970_abnormal_pain_threshold1.07195455
74MP0001661_extended_life_span1.05620039
75MP0000049_abnormal_middle_ear1.04900948
76MP0005645_abnormal_hypothalamus_physiol1.01807347
77MP0003646_muscle_fatigue1.01149248
78MP0002882_abnormal_neuron_morphology0.99759589
79MP0004811_abnormal_neuron_physiology0.99564758
80MP0008569_lethality_at_weaning0.98301735
81MP0002233_abnormal_nose_morphology0.97507318
82MP0003121_genomic_imprinting0.97219698
83MP0003195_calcinosis0.97176583
84MP0004742_abnormal_vestibular_system0.96499488
85MP0003755_abnormal_palate_morphology0.95531745
86MP0002638_abnormal_pupillary_reflex0.95312423
87MP0001944_abnormal_pancreas_morphology0.93622831
88MP0003136_yellow_coat_color0.93410377
89MP0002282_abnormal_trachea_morphology0.93306209
90MP0005386_behavior/neurological_phenoty0.93135373
91MP0004924_abnormal_behavior0.93135373
92MP0002069_abnormal_eating/drinking_beha0.91831546
93MP0005084_abnormal_gallbladder_morpholo0.91780279
94MP0001963_abnormal_hearing_physiology0.90940169
95MP0000631_abnormal_neuroendocrine_gland0.90921990
96MP0004233_abnormal_muscle_weight0.89648013
97MP0001270_distended_abdomen0.88440191
98MP0008260_abnormal_autophagy0.88063201
99MP0000955_abnormal_spinal_cord0.87959786
100MP0010030_abnormal_orbit_morphology0.87774546
101MP0002229_neurodegeneration0.87756734
102MP0002733_abnormal_thermal_nociception0.87736929
103MP0002752_abnormal_somatic_nervous0.87016855
104MP0010094_abnormal_chromosome_stability0.86803189
105MP0003937_abnormal_limbs/digits/tail_de0.86473526
106MP0002751_abnormal_autonomic_nervous0.85825961
107MP0005085_abnormal_gallbladder_physiolo0.85188115
108MP0001905_abnormal_dopamine_level0.85119590
109MP0003122_maternal_imprinting0.84925546
110MP0005389_reproductive_system_phenotype0.84515641
111MP0002152_abnormal_brain_morphology0.84110302
112MP0000566_synostosis0.83459742
113MP0002876_abnormal_thyroid_physiology0.82407373
114MP0004133_heterotaxia0.82166610
115MP0002066_abnormal_motor_capabilities/c0.81485164
116MP0008995_early_reproductive_senescence0.80700036
117MP0004145_abnormal_muscle_electrophysio0.77939887
118MP0001485_abnormal_pinna_reflex0.75596106
119MP0005379_endocrine/exocrine_gland_phen0.71391216
120MP0000026_abnormal_inner_ear0.70929076
121MP0005499_abnormal_olfactory_system0.70105266
122MP0005394_taste/olfaction_phenotype0.70105266
123MP0000569_abnormal_digit_pigmentation0.69503357
124MP0009697_abnormal_copulation0.66525423
125MP0000015_abnormal_ear_pigmentation0.65364109
126MP0001324_abnormal_eye_pigmentation0.63167640
127MP0001765_abnormal_ion_homeostasis0.62942461
128MP0003861_abnormal_nervous_system0.62670419
129MP0003123_paternal_imprinting0.62529746
130MP0006035_abnormal_mitochondrial_morpho0.60757842
131MP0003633_abnormal_nervous_system0.57869598
132MP0005195_abnormal_posterior_eye0.57016211
133MP0003890_abnormal_embryonic-extraembry0.55640052
134MP0002837_dystrophic_cardiac_calcinosis0.54277498

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.76783787
2Abnormal respiratory motile cilium morphology (HP:0005938)7.57238337
3Abnormal respiratory epithelium morphology (HP:0012253)7.57238337
4Abnormal ciliary motility (HP:0012262)6.72686949
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.18842976
6Abnormality of alanine metabolism (HP:0010916)6.18842976
7Hyperalaninemia (HP:0003348)6.18842976
8Rhinitis (HP:0012384)6.09774220
9Chronic bronchitis (HP:0004469)5.59727476
10Congenital sensorineural hearing impairment (HP:0008527)5.19232287
11Infertility (HP:0000789)4.56304139
12Nephronophthisis (HP:0000090)4.04394277
13Medial flaring of the eyebrow (HP:0010747)3.94209530
14Molar tooth sign on MRI (HP:0002419)3.65546110
15Abnormality of midbrain morphology (HP:0002418)3.65546110
16White forelock (HP:0002211)3.42433948
17Gait imbalance (HP:0002141)3.37346694
18Pancreatic fibrosis (HP:0100732)3.32558339
19Bronchiectasis (HP:0002110)3.30794825
20Decreased electroretinogram (ERG) amplitude (HP:0000654)3.24089771
21Congenital primary aphakia (HP:0007707)3.23007802
22Patchy hypopigmentation of hair (HP:0011365)3.12204812
23Nasal polyposis (HP:0100582)3.11044648
24Action tremor (HP:0002345)3.07977209
25Tubulointerstitial nephritis (HP:0001970)3.04592259
26Focal motor seizures (HP:0011153)3.02411521
27Bronchitis (HP:0012387)3.02112128
28True hermaphroditism (HP:0010459)2.99773060
29Nephrogenic diabetes insipidus (HP:0009806)2.96572229
30Abnormality of the renal medulla (HP:0100957)2.95746386
31Abnormality of serum amino acid levels (HP:0003112)2.73871053
32Pendular nystagmus (HP:0012043)2.72159082
33Male infertility (HP:0003251)2.70571708
34Chorioretinal atrophy (HP:0000533)2.66339653
35Birth length less than 3rd percentile (HP:0003561)2.61765799
36Hyperglycinemia (HP:0002154)2.61332392
37Esophageal varix (HP:0002040)2.60242093
38Progressive cerebellar ataxia (HP:0002073)2.59677361
39Homocystinuria (HP:0002156)2.58240620
40Abnormality of homocysteine metabolism (HP:0010919)2.58240620
41Pancreatic cysts (HP:0001737)2.53643493
42Epileptic encephalopathy (HP:0200134)2.52023729
43Genital tract atresia (HP:0001827)2.46473120
44* Constricted visual fields (HP:0001133)2.45766282
45Poor coordination (HP:0002370)2.44483469
46Vaginal atresia (HP:0000148)2.40627035
47Postaxial foot polydactyly (HP:0001830)2.40020936
48Heterochromia iridis (HP:0001100)2.39665585
49Intestinal atresia (HP:0011100)2.37235942
50Atonic seizures (HP:0010819)2.31941618
51Generalized aminoaciduria (HP:0002909)2.30768802
52Decreased central vision (HP:0007663)2.30547249
53Poor speech (HP:0002465)2.30420538
54Spontaneous hematomas (HP:0007420)2.29515622
55Febrile seizures (HP:0002373)2.26463601
56Recurrent sinusitis (HP:0011108)2.26372264
57Postaxial hand polydactyly (HP:0001162)2.25561334
58Median cleft lip (HP:0000161)2.24805984
59Abnormal spermatogenesis (HP:0008669)2.24771548
60Abnormality of the renal cortex (HP:0011035)2.23678782
61Abolished electroretinogram (ERG) (HP:0000550)2.22117346
62Abnormality of sulfur amino acid metabolism (HP:0004339)2.19859635
63Congenital stationary night blindness (HP:0007642)2.19061111
64Supernumerary spleens (HP:0009799)2.19013324
65Myokymia (HP:0002411)2.18975105
66Abnormality of the nasal mucosa (HP:0000433)2.18268155
67Cystic liver disease (HP:0006706)2.17261296
68Conjugated hyperbilirubinemia (HP:0002908)2.17204299
69Aplasia/Hypoplasia of the lens (HP:0008063)2.16056155
70Thyroid-stimulating hormone excess (HP:0002925)2.13692072
71Maternal diabetes (HP:0009800)2.11674977
72Congenital hepatic fibrosis (HP:0002612)2.07693099
73Keratoconus (HP:0000563)2.07192603
74Increased corneal curvature (HP:0100692)2.07192603
75Aplasia/Hypoplasia of the tongue (HP:0010295)2.07066828
76Oculomotor apraxia (HP:0000657)2.06354326
77Abnormal umbilical cord blood vessels (HP:0011403)2.06345529
78Single umbilical artery (HP:0001195)2.06345529
79Abnormality of the fetal cardiovascular system (HP:0010948)2.06345529
80Methylmalonic acidemia (HP:0002912)2.04023383
81Abnormal rod and cone electroretinograms (HP:0008323)2.02382411
82Gaze-evoked nystagmus (HP:0000640)2.01849941
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.4147805
84Absent/shortened dynein arms (HP:0200106)10.0218632
85Dynein arm defect of respiratory motile cilia (HP:0012255)10.0218632
86Epidermoid cyst (HP:0200040)1.99037165
87Recurrent otitis media (HP:0000403)1.94351955
88Optic nerve hypoplasia (HP:0000609)1.92583866
89Chronic hepatic failure (HP:0100626)1.90598910
90Hypoalphalipoproteinemia (HP:0003233)1.90486076
91Oligomenorrhea (HP:0000876)1.88085195
92Dyskinesia (HP:0100660)1.87946537
93Impulsivity (HP:0100710)1.86574785
94Pigmentary retinal degeneration (HP:0001146)1.85506990
95Tubulointerstitial abnormality (HP:0001969)1.85437335
96Occipital encephalocele (HP:0002085)1.84650059
97Facial cleft (HP:0002006)1.82968854
98Small hand (HP:0200055)1.82393005
99Conjunctival telangiectasia (HP:0000524)1.81681143
100Preaxial hand polydactyly (HP:0001177)1.78643327
101Oligodactyly (hands) (HP:0001180)1.77387949
102Dyschromatopsia (HP:0007641)1.76745278
103Focal seizures (HP:0007359)1.74861644
104Genetic anticipation (HP:0003743)1.73227532
105Proximal tubulopathy (HP:0000114)1.73134611
106Renal cortical cysts (HP:0000803)1.72577706
107Hyperventilation (HP:0002883)1.72443182
108Cone-rod dystrophy (HP:0000548)1.72273369
109Metaphyseal dysplasia (HP:0100255)1.71174727
110Gonadotropin excess (HP:0000837)1.70832141
111Limb dystonia (HP:0002451)1.70301188
112Anophthalmia (HP:0000528)1.69848556
113Stenosis of the external auditory canal (HP:0000402)1.67999038
114Bifid tongue (HP:0010297)1.66465614
115Visceral angiomatosis (HP:0100761)1.66436274
116Broad-based gait (HP:0002136)1.66191345
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.64966484
118Abnormality of macular pigmentation (HP:0008002)1.63208452
119Hypothermia (HP:0002045)1.62812733
120Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.59361176
121Absence seizures (HP:0002121)1.59101647
122Short tibia (HP:0005736)1.58705288
123Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.58540872
124Abnormal hair whorl (HP:0010721)1.56904176
125Nephroblastoma (Wilms tumor) (HP:0002667)1.56764063
126Sclerocornea (HP:0000647)1.54527629
127Tubular atrophy (HP:0000092)1.54278698
128Abnormal biliary tract physiology (HP:0012439)1.54248294
129Bile duct proliferation (HP:0001408)1.54248294
130Impaired vibration sensation in the lower limbs (HP:0002166)1.54216929
131Anencephaly (HP:0002323)1.54215770
132Specific learning disability (HP:0001328)1.53280350
133Aganglionic megacolon (HP:0002251)1.52850647
134Polyphagia (HP:0002591)1.51724559
135Abnormality of the labia minora (HP:0012880)1.51688417
136Embryonal renal neoplasm (HP:0011794)1.51163362
137Broad foot (HP:0001769)1.51134925
138Chronic sinusitis (HP:0011109)1.51040057
139Hemiparesis (HP:0001269)1.50077497
140Abnormality of permanent molar morphology (HP:0011071)1.49388192
141Abnormality of the dental root (HP:0006486)1.49388192
142Taurodontia (HP:0000679)1.49388192
143Male pseudohermaphroditism (HP:0000037)1.49118479
144Dialeptic seizures (HP:0011146)1.48673699
145Inability to walk (HP:0002540)1.46301448
146Fibular hypoplasia (HP:0003038)1.46179354
147Retinitis pigmentosa (HP:0000510)1.44363073
148Attenuation of retinal blood vessels (HP:0007843)1.43399859
149Hypoplasia of the capital femoral epiphysis (HP:0003090)1.43083242
150Astigmatism (HP:0000483)1.42909341
151Retinal dysplasia (HP:0007973)1.41059294
152Narrow forehead (HP:0000341)1.40174541
153Abnormality of molar (HP:0011077)1.39306192
154Abnormality of molar morphology (HP:0011070)1.39306192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.40245270
2PDK36.40245270
3FRK4.19140769
4PDK24.09064940
5MAP4K23.26912149
6ACVR1B3.23328483
7CASK3.07475190
8PRKD32.72189977
9TESK12.60336543
10PNCK2.42263856
11NTRK32.35281798
12MAP2K72.08937696
13TNIK1.89616699
14CCNB11.75517443
15AKT31.75263031
16ICK1.71557419
17EPHA41.69191122
18STK161.67993131
19MAP3K41.65344440
20NUAK11.63562926
21TRIM281.63232490
22FGR1.58152367
23CDK91.55702189
24PRPF4B1.54885040
25GRK11.49275524
26DYRK21.47918734
27MAP3K31.45685531
28EPHB21.40336299
29PTK2B1.35086826
30FGFR21.32408634
31ADRBK11.26115624
32PLK21.25590605
33RIPK41.24592622
34BMPR21.24417892
35BRAF1.22673807
36STK391.20897964
37MARK11.19177676
38MAPK131.17040899
39STK381.16641595
40MUSK1.10302926
41PLK41.07748645
42MINK11.04772692
43SGK31.02965017
44MAP3K121.02850976
45WNK41.01463976
46PRKCG1.00977799
47PAK31.00748138
48NTRK20.99988085
49ZAK0.98176944
50CSNK1G10.97883160
51CSNK1G20.96875168
52STK38L0.96062057
53MAP2K30.95999186
54CAMKK20.94264927
55ADRBK20.91430065
56YES10.90814893
57CHEK20.90401744
58ERBB30.89555323
59CDK30.88493545
60ARAF0.84717587
61JAK30.84358613
62CSNK1G30.83567234
63CDK190.82976347
64DAPK10.81338369
65NEK60.79826112
66CSNK1A10.79735668
67WNK30.79544953
68MAP3K90.77542026
69PDK10.74531613
70BMPR1B0.73634055
71OXSR10.73611898
72MAP2K40.72994995
73CAMK10.72818618
74TRPM70.71141321
75BCKDK0.69926903
76GRK50.67762593
77DAPK20.67081879
78CSNK1A1L0.66831153
79BCR0.65702410
80MAPK150.65223508
81PASK0.65062009
82TTK0.63388520
83CAMK2A0.62343815
84STK30.62041626
85NME10.61176651
86INSRR0.61041651
87WEE10.60116903
88MKNK10.59551618
89CDK180.59081562
90TAOK30.58452304
91MAP2K10.58319041
92MAP3K60.57804581
93RPS6KB20.55938475
94TAF10.55783354
95SRPK10.55516768
96BRD40.55032067
97CDK150.54686142
98SGK4940.54406861
99SGK2230.54406861
100TSSK60.54339792
101CDK80.53918522
102CAMKK10.53914454
103BRSK20.53869745
104CAMK2B0.52802824
105DYRK30.52666595
106MAP2K60.51726199
107TIE10.51530693
108OBSCN0.50654216
109CDK50.50226029
110NEK20.50192584
111MKNK20.49529224
112SGK10.48763490
113SGK20.48548715
114PRKACA0.48544583
115PBK0.47795402
116IRAK10.47523101
117GRK70.47024488
118PINK10.46920019
119CDK11A0.46735426
120BUB10.46655042
121PKN10.46642819
122PAK60.46011314
123TGFBR10.46004446
124IRAK20.45868593
125CDK140.44493052
126PIK3CA0.44142983
127DYRK1A0.42652452
128SIK30.40866107
129PLK30.40776787
130CAMK1G0.40552041
131PHKG10.40458301
132PHKG20.40458301
133UHMK10.39568744
134DYRK1B0.38487997
135RPS6KB10.38283264
136PRKAA10.37525762
137CHEK10.37135004
138PRKCA0.36491958
139PDPK10.35529801
140PLK10.35242785
141PRKG10.33599113
142BRSK10.33517880
143PRKCE0.33127347
144VRK10.32891845
145CAMK2D0.32825365
146LMTK20.31288522
147STK110.31283885
148LATS10.30189148

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.27724183
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.19877881
3Synaptic vesicle cycle_Homo sapiens_hsa047212.88304669
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.68357037
5Olfactory transduction_Homo sapiens_hsa047402.65553288
6Collecting duct acid secretion_Homo sapiens_hsa049662.65369191
7Vitamin B6 metabolism_Homo sapiens_hsa007502.49717543
8Taste transduction_Homo sapiens_hsa047422.49578025
9Amphetamine addiction_Homo sapiens_hsa050312.41895504
10One carbon pool by folate_Homo sapiens_hsa006702.33095952
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32013572
12Selenocompound metabolism_Homo sapiens_hsa004502.20697951
13Basal transcription factors_Homo sapiens_hsa030222.20535062
14Arginine biosynthesis_Homo sapiens_hsa002202.16551901
15Circadian entrainment_Homo sapiens_hsa047132.14967630
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12899125
17Butanoate metabolism_Homo sapiens_hsa006502.10579226
18Morphine addiction_Homo sapiens_hsa050322.07776169
19Insulin secretion_Homo sapiens_hsa049112.01809352
20Glutamatergic synapse_Homo sapiens_hsa047242.00750877
21Sulfur metabolism_Homo sapiens_hsa009202.00549886
22Long-term potentiation_Homo sapiens_hsa047201.98803801
23Fanconi anemia pathway_Homo sapiens_hsa034601.81544206
24Oocyte meiosis_Homo sapiens_hsa041141.77328283
25GABAergic synapse_Homo sapiens_hsa047271.76066037
26Sulfur relay system_Homo sapiens_hsa041221.69225800
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.62406891
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60233140
29Huntingtons disease_Homo sapiens_hsa050161.58037307
30Vibrio cholerae infection_Homo sapiens_hsa051101.57789460
31Salivary secretion_Homo sapiens_hsa049701.55847220
32Serotonergic synapse_Homo sapiens_hsa047261.51520764
33Dopaminergic synapse_Homo sapiens_hsa047281.49588641
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45830970
35Calcium signaling pathway_Homo sapiens_hsa040201.45204972
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44852579
37Renin secretion_Homo sapiens_hsa049241.44055514
38Phototransduction_Homo sapiens_hsa047441.43970863
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41411978
40Cardiac muscle contraction_Homo sapiens_hsa042601.40919887
41Pyruvate metabolism_Homo sapiens_hsa006201.40599033
42Glucagon signaling pathway_Homo sapiens_hsa049221.37420190
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36486128
44Nitrogen metabolism_Homo sapiens_hsa009101.36093815
45Propanoate metabolism_Homo sapiens_hsa006401.35238053
46Oxidative phosphorylation_Homo sapiens_hsa001901.34970650
47Fatty acid biosynthesis_Homo sapiens_hsa000611.31577121
48Linoleic acid metabolism_Homo sapiens_hsa005911.28542462
49Purine metabolism_Homo sapiens_hsa002301.28358007
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27377192
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22424364
52Peroxisome_Homo sapiens_hsa041461.20280508
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18598818
54Retinol metabolism_Homo sapiens_hsa008301.16579381
55Ether lipid metabolism_Homo sapiens_hsa005651.15239732
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14895013
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12117818
58ABC transporters_Homo sapiens_hsa020101.07618114
59Tryptophan metabolism_Homo sapiens_hsa003801.05244760
60SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03841948
61Caffeine metabolism_Homo sapiens_hsa002321.03528386
62Gastric acid secretion_Homo sapiens_hsa049711.03471659
63Steroid biosynthesis_Homo sapiens_hsa001001.01637529
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00217312
65Cholinergic synapse_Homo sapiens_hsa047251.00092892
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99132304
67mRNA surveillance pathway_Homo sapiens_hsa030150.98976304
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.98166692
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97156391
70Cocaine addiction_Homo sapiens_hsa050300.96617414
71Oxytocin signaling pathway_Homo sapiens_hsa049210.94363169
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93202401
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92546268
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.91109158
75Long-term depression_Homo sapiens_hsa047300.90631737
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90073757
77Chemical carcinogenesis_Homo sapiens_hsa052040.88568110
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87043352
79Alzheimers disease_Homo sapiens_hsa050100.86472943
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85864560
81Vitamin digestion and absorption_Homo sapiens_hsa049770.85206913
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83423523
83cAMP signaling pathway_Homo sapiens_hsa040240.82413640
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82182086
85Arginine and proline metabolism_Homo sapiens_hsa003300.81002508
86Parkinsons disease_Homo sapiens_hsa050120.80263027
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79893538
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.79578406
89Proteasome_Homo sapiens_hsa030500.77510259
90Rheumatoid arthritis_Homo sapiens_hsa053230.76845648
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76142076
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73367968
93Thyroid hormone synthesis_Homo sapiens_hsa049180.72404858
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72031439
95Estrogen signaling pathway_Homo sapiens_hsa049150.71274674
96RNA transport_Homo sapiens_hsa030130.70904743
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70080596
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68750646
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68561022
100Mineral absorption_Homo sapiens_hsa049780.67287014
101Non-homologous end-joining_Homo sapiens_hsa034500.66466719
102Circadian rhythm_Homo sapiens_hsa047100.66399317
103Ovarian steroidogenesis_Homo sapiens_hsa049130.66353304
104Fructose and mannose metabolism_Homo sapiens_hsa000510.66350390
105Type I diabetes mellitus_Homo sapiens_hsa049400.65639820
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65624930
107Alcoholism_Homo sapiens_hsa050340.63981540
108Folate biosynthesis_Homo sapiens_hsa007900.63851681
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63305547
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62296667
111Metabolic pathways_Homo sapiens_hsa011000.62193365
112beta-Alanine metabolism_Homo sapiens_hsa004100.62123320
113Pancreatic secretion_Homo sapiens_hsa049720.61054793
114Homologous recombination_Homo sapiens_hsa034400.58398104
115Gap junction_Homo sapiens_hsa045400.58122979
116Dorso-ventral axis formation_Homo sapiens_hsa043200.57452966
117Regulation of autophagy_Homo sapiens_hsa041400.56989764
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56702204
119Protein export_Homo sapiens_hsa030600.55834919
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55159593
121RNA degradation_Homo sapiens_hsa030180.55022759
122Hedgehog signaling pathway_Homo sapiens_hsa043400.50681119
123Inositol phosphate metabolism_Homo sapiens_hsa005620.50357249
124Pyrimidine metabolism_Homo sapiens_hsa002400.49678884
125Fat digestion and absorption_Homo sapiens_hsa049750.49567402
126GnRH signaling pathway_Homo sapiens_hsa049120.47291919
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.46695240
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46573476
129Type II diabetes mellitus_Homo sapiens_hsa049300.45126436
130Arachidonic acid metabolism_Homo sapiens_hsa005900.43506871
131Phagosome_Homo sapiens_hsa041450.43436926
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.42142134
133Axon guidance_Homo sapiens_hsa043600.41393584
134Cell cycle_Homo sapiens_hsa041100.40895772
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40235673
136MAPK signaling pathway_Homo sapiens_hsa040100.40188962
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39189268
138Sphingolipid metabolism_Homo sapiens_hsa006000.37997857
139Fatty acid metabolism_Homo sapiens_hsa012120.37148198
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35152488
141Histidine metabolism_Homo sapiens_hsa003400.34487676
142Basal cell carcinoma_Homo sapiens_hsa052170.33749655
143Hippo signaling pathway_Homo sapiens_hsa043900.32666100
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27149570
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27006345
146Fatty acid degradation_Homo sapiens_hsa000710.26887443
147Biosynthesis of amino acids_Homo sapiens_hsa012300.24102866

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