SPATA9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.80900277
2plasma membrane fusion (GO:0045026)9.71514206
3binding of sperm to zona pellucida (GO:0007339)9.66815128
4cilium or flagellum-dependent cell motility (GO:0001539)9.24753858
5reproduction (GO:0000003)9.05477169
6epithelial cilium movement (GO:0003351)9.01663927
7protoporphyrinogen IX metabolic process (GO:0046501)8.80716300
8spermatid development (GO:0007286)8.72942370
9axonemal dynein complex assembly (GO:0070286)8.60471455
10motile cilium assembly (GO:0044458)8.23108426
11protoporphyrinogen IX biosynthetic process (GO:0006782)7.98115377
12regulation of cilium movement (GO:0003352)7.67766227
13cilium movement (GO:0003341)7.51362897
14male meiosis (GO:0007140)7.27289270
15single fertilization (GO:0007338)6.95668040
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.71896037
17sperm capacitation (GO:0048240)6.69832231
18piRNA metabolic process (GO:0034587)6.39274359
19synaptonemal complex organization (GO:0070193)6.37492472
20synaptonemal complex assembly (GO:0007130)6.33300971
21microtubule depolymerization (GO:0007019)6.32609689
22limb bud formation (GO:0060174)6.27196516
23porphyrin-containing compound biosynthetic process (GO:0006779)5.91073674
24gas transport (GO:0015669)5.90336057
25negative regulation of inclusion body assembly (GO:0090084)5.82324824
26fertilization (GO:0009566)5.79514460
27* spermatogenesis (GO:0007283)5.78083264
28* male gamete generation (GO:0048232)5.75461123
29organic cation transport (GO:0015695)5.60117223
30calcium ion-dependent exocytosis (GO:0017156)5.59416271
31oxygen transport (GO:0015671)5.58031659
32* gamete generation (GO:0007276)5.36458074
33tetrapyrrole biosynthetic process (GO:0033014)5.35188874
34cell recognition (GO:0008037)5.31370173
35ether metabolic process (GO:0018904)5.24093975
36heme biosynthetic process (GO:0006783)5.09962908
37ventricular system development (GO:0021591)4.98494404
38microtubule severing (GO:0051013)4.96724667
39cellular process involved in reproduction in multicellular organism (GO:0022412)4.94758001
40porphyrin-containing compound metabolic process (GO:0006778)4.93012008
41germ cell development (GO:0007281)4.75756335
42spermatid nucleus differentiation (GO:0007289)4.70771962
43regulation of inclusion body assembly (GO:0090083)4.68893706
44chromosome organization involved in meiosis (GO:0070192)4.65065351
45erythrocyte maturation (GO:0043249)4.65048543
46glycerol ether metabolic process (GO:0006662)4.63426150
47DNA methylation involved in gamete generation (GO:0043046)4.51663566
48male meiosis I (GO:0007141)4.50637363
49regulation of microtubule-based movement (GO:0060632)4.46424534
50DNA double-strand break processing (GO:0000729)4.28524092
51* multicellular organismal reproductive process (GO:0048609)4.22648063
52heme metabolic process (GO:0042168)4.18026939
53erythrocyte development (GO:0048821)4.11939668
54one-carbon compound transport (GO:0019755)4.11097169
55chaperone-mediated protein complex assembly (GO:0051131)4.08062341
56meiotic nuclear division (GO:0007126)3.98527053
57centriole replication (GO:0007099)3.86354522
58chromosome condensation (GO:0030261)3.82613973
59monoubiquitinated protein deubiquitination (GO:0035520)3.68777254
60protein polyglutamylation (GO:0018095)3.65673717
61rRNA methylation (GO:0031167)3.61143834
62seminiferous tubule development (GO:0072520)3.59502390
63left/right pattern formation (GO:0060972)3.55888450
64DNA packaging (GO:0006323)3.52909259
65meiosis I (GO:0007127)3.51576625
66synapsis (GO:0007129)3.49901664
67GTP biosynthetic process (GO:0006183)3.48606795
68valine metabolic process (GO:0006573)3.48182817
69definitive hemopoiesis (GO:0060216)3.45070557
70cell migration in hindbrain (GO:0021535)3.43987509
71* multicellular organismal development (GO:0007275)3.40627743
72cellular ketone body metabolic process (GO:0046950)3.37734565
73protein localization to cilium (GO:0061512)3.37464970
74iron ion import (GO:0097286)3.32531937
75centriole assembly (GO:0098534)3.31475686
76tetrapyrrole metabolic process (GO:0033013)3.31459537
77detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.30328945
78cilium organization (GO:0044782)3.25735165
79microtubule polymerization or depolymerization (GO:0031109)3.24396327
80genitalia morphogenesis (GO:0035112)3.21770475
81cilium assembly (GO:0042384)3.17764335
82response to methylmercury (GO:0051597)3.11978043
83hemoglobin metabolic process (GO:0020027)3.10613746
84detection of light stimulus involved in visual perception (GO:0050908)3.10055449
85detection of light stimulus involved in sensory perception (GO:0050962)3.10055449
86nucleoside diphosphate phosphorylation (GO:0006165)3.09414474
87gonadal mesoderm development (GO:0007506)3.09013817
88intraciliary transport (GO:0042073)3.08447751
89folic acid-containing compound biosynthetic process (GO:0009396)3.08394812
90rRNA modification (GO:0000154)3.07710814
91cellular component assembly involved in morphogenesis (GO:0010927)3.07310979
92mitochondrion transport along microtubule (GO:0047497)3.07222535
93establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.07222535
94positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.07152658
95mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.07152658
96polyol catabolic process (GO:0046174)3.06163533
97calcium ion import (GO:0070509)3.01125451
98UTP biosynthetic process (GO:0006228)2.98914639
99establishment of mitochondrion localization (GO:0051654)2.97786851
100negative regulation of mast cell activation (GO:0033004)2.96179829
101ketone body metabolic process (GO:1902224)2.94066449
102glycine transport (GO:0015816)2.94004764
103protein K11-linked deubiquitination (GO:0035871)2.92227150
104positive regulation of fibroblast migration (GO:0010763)2.91628649
105regulation of glucokinase activity (GO:0033131)2.91487094
106regulation of hexokinase activity (GO:1903299)2.91487094
107protein-cofactor linkage (GO:0018065)2.90576375
108pteridine-containing compound biosynthetic process (GO:0042559)2.90403422
109myeloid cell development (GO:0061515)2.89543446
110carnitine transport (GO:0015879)2.85993571
111amino-acid betaine transport (GO:0015838)2.85993571
112axoneme assembly (GO:0035082)2.85783286
113replication fork processing (GO:0031297)2.83763459
114microtubule-based movement (GO:0007018)2.82313463
115regulation of spindle checkpoint (GO:0090231)2.80213482
116membrane depolarization during action potential (GO:0086010)2.79711416
117negative regulation of organelle assembly (GO:1902116)2.79401409
118carnitine transmembrane transport (GO:1902603)2.76088883
119DNA topological change (GO:0006265)2.76011756
120mitotic sister chromatid cohesion (GO:0007064)2.74259710
121positive regulation of histone methylation (GO:0031062)2.73784725
122lateral ventricle development (GO:0021670)2.73061100
123UTP metabolic process (GO:0046051)2.72054156
124cilium morphogenesis (GO:0060271)2.70487137
125meiotic chromosome segregation (GO:0045132)2.70291010
126alditol metabolic process (GO:0019400)2.68333315
127negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.68222436
128sensory perception of smell (GO:0007608)2.66514782
129protein refolding (GO:0042026)2.65637562
130regulation of centriole replication (GO:0046599)2.65571304
131lactate metabolic process (GO:0006089)2.61857448
132zinc ion homeostasis (GO:0055069)2.61822775
133CDP-diacylglycerol biosynthetic process (GO:0016024)2.59716675
134GMP metabolic process (GO:0046037)2.59441020
135histone mRNA catabolic process (GO:0071044)2.58910788
136negative regulation of execution phase of apoptosis (GO:1900118)2.58315151
137glucocorticoid biosynthetic process (GO:0006704)2.57969194
138histone H2A acetylation (GO:0043968)2.57759403
139negative regulation of norepinephrine secretion (GO:0010700)2.57481251
140pharyngeal system development (GO:0060037)2.57285360
141histone exchange (GO:0043486)2.56467546
142positive regulation of histone H3-K4 methylation (GO:0051571)2.55888350
143cullin deneddylation (GO:0010388)2.54825593
144sialylation (GO:0097503)2.54733143
145sequestering of extracellular ligand from receptor (GO:0035581)2.54471943
146zinc ion transmembrane transport (GO:0071577)2.52442388
147meiotic cell cycle process (GO:1903046)2.52383695
148centrosome duplication (GO:0051298)2.51610861
149regulation of timing of cell differentiation (GO:0048505)2.49694063
150meiotic cell cycle (GO:0051321)2.49683476
151phosphatidylethanolamine metabolic process (GO:0046337)2.48846948
152removal of superoxide radicals (GO:0019430)2.48438001
153cellular response to superoxide (GO:0071451)2.48438001
154cellular response to oxygen radical (GO:0071450)2.48438001
155positive regulation of macrophage activation (GO:0043032)2.48299992
156left/right axis specification (GO:0070986)2.48062119
157cornea development in camera-type eye (GO:0061303)2.46422440
158neural tube formation (GO:0001841)2.46227426
159granulocyte differentiation (GO:0030851)2.45011545
160glycolytic process (GO:0006096)2.43852501
161negative regulation of sodium ion transport (GO:0010766)2.43660032
162regulation of histone H3-K4 methylation (GO:0051569)2.43581945
163single strand break repair (GO:0000012)2.42362334
164UDP-N-acetylglucosamine metabolic process (GO:0006047)2.42298494
165glycerol metabolic process (GO:0006071)2.41915402
166cofactor biosynthetic process (GO:0051188)2.40980102
167CTP biosynthetic process (GO:0006241)2.40879425
168CTP metabolic process (GO:0046036)2.40879425
169pigment biosynthetic process (GO:0046148)2.40082528
170L-ascorbic acid metabolic process (GO:0019852)2.40021333
171cardiac ventricle formation (GO:0003211)2.39825368
172negative regulation of fatty acid metabolic process (GO:0045922)2.39789133
173glial cell proliferation (GO:0014009)2.39658892
174guanosine-containing compound biosynthetic process (GO:1901070)2.39530853
175nuclear pore organization (GO:0006999)2.37285409
176positive regulation of protein autophosphorylation (GO:0031954)2.36248789
177ubiquinone biosynthetic process (GO:0006744)2.34568601
178centrosome localization (GO:0051642)2.33685188
179cell wall macromolecule catabolic process (GO:0016998)12.9859625
180cell wall macromolecule metabolic process (GO:0044036)12.9859625
181fusion of sperm to egg plasma membrane (GO:0007342)12.5246115
182acrosome assembly (GO:0001675)12.4218283
183sperm motility (GO:0030317)12.1634474
184sperm-egg recognition (GO:0035036)11.0235745
185multicellular organism reproduction (GO:0032504)10.9846671
186acrosome reaction (GO:0007340)10.4948758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.54278422
2EZH2_22144423_ChIP-Seq_EOC_Human5.91183043
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.72174547
4E2F7_22180533_ChIP-Seq_HELA_Human4.66498250
5GATA1_22025678_ChIP-Seq_K562_Human4.47628445
6GATA1_19941826_ChIP-Seq_K562_Human3.69115760
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.33434612
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.09579075
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77693045
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.76486858
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74161753
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.64610978
13VDR_22108803_ChIP-Seq_LS180_Human2.41588054
14ZNF274_21170338_ChIP-Seq_K562_Hela2.41316179
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40450459
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.29130796
17* GATA2_19941826_ChIP-Seq_K562_Human2.23430415
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.17390866
19IGF1R_20145208_ChIP-Seq_DFB_Human2.10784354
20SCL_19346495_ChIP-Seq_HPC-7_Human2.08476953
21ER_23166858_ChIP-Seq_MCF-7_Human2.03206881
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02571385
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93654649
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.92171538
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85940339
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84038476
27DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.83108943
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83053688
29SALL4_22934838_ChIP-ChIP_CD34+_Human1.80764721
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.77369257
31* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.77029774
32REST_21632747_ChIP-Seq_MESCs_Mouse1.77014794
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.75994529
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71766318
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.70759949
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.69976622
37TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68310732
38KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.66875614
39KDM2B_26808549_Chip-Seq_REH_Human1.66593750
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.66138750
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60517683
42RNF2_27304074_Chip-Seq_NSC_Mouse1.59593156
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59378525
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55885836
45* TAL1_26923725_Chip-Seq_HPCs_Mouse1.53992993
46GBX2_23144817_ChIP-Seq_PC3_Human1.53201451
47TAF15_26573619_Chip-Seq_HEK293_Human1.52316996
48MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51790543
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51754406
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51656173
51CBP_20019798_ChIP-Seq_JUKART_Human1.51656173
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50242738
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.50056032
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49091844
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47528443
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47449495
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47449495
58TP53_22573176_ChIP-Seq_HFKS_Human1.46062804
59VDR_23849224_ChIP-Seq_CD4+_Human1.44793315
60STAT1_17558387_ChIP-Seq_HELA_Human1.44417179
61CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.42489139
62ELK1_19687146_ChIP-ChIP_HELA_Human1.42007193
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.40960093
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.39758690
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39577946
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.38176808
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37849560
68FUS_26573619_Chip-Seq_HEK293_Human1.37636561
69ELK4_26923725_Chip-Seq_MESODERM_Mouse1.37277987
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36374064
71GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.35693823
72P53_22387025_ChIP-Seq_ESCs_Mouse1.35495244
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.34554124
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33455812
75WDR5_24793694_ChIP-Seq_LNCAP_Human1.33023671
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29400940
77ETV1_20927104_ChIP-Seq_GIST48_Human1.28321815
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26636647
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25521397
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25340387
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.25158278
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24032558
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22937863
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22407331
85* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21995380
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21853553
87PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.20964256
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.20837679
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20837120
90P300_18555785_Chip-Seq_ESCs_Mouse1.20655329
91SMAD4_21799915_ChIP-Seq_A2780_Human1.19806585
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.18706072
93KAP1_22055183_ChIP-Seq_ESCs_Mouse1.18216012
94ETS1_20019798_ChIP-Seq_JURKAT_Human1.17945351
95SOX2_22085726_ChIP-Seq_NPCs_Mouse1.16552183
96STAT3_23295773_ChIP-Seq_U87_Human1.16513582
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15385825
98SOX9_26525672_Chip-Seq_HEART_Mouse1.14943809
99ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14817750
100* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14144316
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.13200423
102EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12607703
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12584322
104FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12403609
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.12320627
106GATA3_21867929_ChIP-Seq_TH1_Mouse1.11606646
107SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11578234
108ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11144752
109KLF4_18555785_Chip-Seq_ESCs_Mouse1.10759664
110POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10713695
111JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10333029
112NFYB_21822215_ChIP-Seq_K562_Human1.10058337
113KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09622134
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.09447789
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.09308993
116SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08109953
117RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08026456
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08011739
119RBPJ_21746931_ChIP-Seq_IB4_Human1.07860385
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07653882
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06510194
122LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.06297493
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05889004
124EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05368909
125DCP1A_22483619_ChIP-Seq_HELA_Human1.04265047
126NCOR1_26117541_ChIP-Seq_K562_Human1.04194066
127P300_19829295_ChIP-Seq_ESCs_Human1.04111837
128GATA3_21867929_ChIP-Seq_CD8_Mouse1.04019941
129TBL1_22424771_ChIP-Seq_293T_Human1.03875014
130CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03358167
131RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02736306
132GF1_26923725_Chip-Seq_HPCs_Mouse1.02729069
133PHF8_20622853_ChIP-Seq_HELA_Human1.02718954
134OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00914515
135PRDM14_20953172_ChIP-Seq_ESCs_Human1.00700214
136AR_25329375_ChIP-Seq_VCAP_Human1.00639873
137TCF4_23295773_ChIP-Seq_U87_Human1.00539219
138RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00359976
139CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00068503
140CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00011522
141EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99943063
142CTCF_18555785_Chip-Seq_ESCs_Mouse0.99705438
143CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98863420
144NMYC_18555785_Chip-Seq_ESCs_Mouse0.98745816
145RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98606477
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98237408
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98207719
148SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98187844
149NFYA_21822215_ChIP-Seq_K562_Human0.97588852
150FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97491545
151PU1_27457419_Chip-Seq_LIVER_Mouse0.96895299
152EWS_26573619_Chip-Seq_HEK293_Human0.96712383
153EZH2_27294783_Chip-Seq_ESCs_Mouse0.96571527
154* SMAD3_21741376_ChIP-Seq_EPCs_Human0.96084814
155PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95600182
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95544532
157SPI1_23127762_ChIP-Seq_K562_Human0.95243317
158TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95233241
159PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94495746
160MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94424897
161PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93981236
162KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93036168
163MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92154511
164FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91760058
165PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91291292
166TCF4_22108803_ChIP-Seq_LS180_Human0.90185850
167PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89691436
168OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89089009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level7.38485130
2MP0003698_abnormal_male_reproductive5.37548511
3MP0001929_abnormal_gametogenesis4.88469914
4MP0008877_abnormal_DNA_methylation4.12312935
5MP0002822_catalepsy3.40664293
6MP0002210_abnormal_sex_determination3.11854315
7MP0002161_abnormal_fertility/fecundity2.92739744
8MP0005397_hematopoietic_system_phenotyp2.76666568
9MP0001545_abnormal_hematopoietic_system2.76666568
10MP0003950_abnormal_plasma_membrane2.73952741
11MP0001145_abnormal_male_reproductive2.60218701
12MP0003718_maternal_effect2.42160769
13MP0002653_abnormal_ependyma_morphology2.33439130
14MP0000653_abnormal_sex_gland2.31224108
15MP0008057_abnormal_DNA_replication2.26422052
16MP0005171_absent_coat_pigmentation2.20907430
17MP0009046_muscle_twitch2.18416550
18MP0003880_abnormal_central_pattern2.11871402
19MP0000372_irregular_coat_pigmentation2.07259555
20MP0005670_abnormal_white_adipose2.06535672
21MP0005410_abnormal_fertilization13.8760036
22MP0005075_abnormal_melanosome_morpholog1.99060837
23MP0003186_abnormal_redox_activity1.92834040
24MP0005083_abnormal_biliary_tract1.91187131
25MP0004145_abnormal_muscle_electrophysio1.69335909
26MP0003890_abnormal_embryonic-extraembry1.66786431
27MP0010094_abnormal_chromosome_stability1.66439896
28MP0005623_abnormal_meninges_morphology1.65136355
29MP0003646_muscle_fatigue1.64403706
30MP0000371_diluted_coat_color1.64197205
31MP0004859_abnormal_synaptic_plasticity1.61715582
32MP0001984_abnormal_olfaction1.61104828
33MP0004270_analgesia1.58224408
34MP0005451_abnormal_body_composition1.58173384
35MP0005666_abnormal_adipose_tissue1.54538537
36MP0002160_abnormal_reproductive_system1.51781024
37MP0006036_abnormal_mitochondrial_physio1.39989039
38MP0002572_abnormal_emotion/affect_behav1.35735258
39MP0004233_abnormal_muscle_weight1.34394994
40MP0003635_abnormal_synaptic_transmissio1.33134245
41MP0000015_abnormal_ear_pigmentation1.30415434
42MP0005367_renal/urinary_system_phenotyp1.29624615
43MP0000516_abnormal_urinary_system1.29624615
44MP0001968_abnormal_touch/_nociception1.28463909
45MP0002735_abnormal_chemical_nociception1.25964521
46MP0001529_abnormal_vocalization1.24014809
47MP0005645_abnormal_hypothalamus_physiol1.20676247
48MP0009745_abnormal_behavioral_response1.20178634
49MP0002063_abnormal_learning/memory/cond1.19402890
50MP0008438_abnormal_cutaneous_collagen1.19345565
51MP0002282_abnormal_trachea_morphology1.16526182
52MP0005551_abnormal_eye_electrophysiolog1.15784777
53MP0002736_abnormal_nociception_after1.15664062
54MP0005408_hypopigmentation1.13867687
55MP0003111_abnormal_nucleus_morphology1.10149152
56MP0004957_abnormal_blastocyst_morpholog1.09377090
57MP0002075_abnormal_coat/hair_pigmentati1.09224207
58MP0002234_abnormal_pharynx_morphology1.08675032
59MP0002095_abnormal_skin_pigmentation1.07969171
60MP0003077_abnormal_cell_cycle1.07269787
61MP0008995_early_reproductive_senescence1.05785209
62MP0005174_abnormal_tail_pigmentation1.05585566
63MP0001486_abnormal_startle_reflex1.04598004
64MP0003221_abnormal_cardiomyocyte_apopto1.04562178
65MP0005360_urolithiasis1.04183221
66MP0008775_abnormal_heart_ventricle1.04148952
67MP0001765_abnormal_ion_homeostasis1.03936354
68MP0005647_abnormal_sex_gland1.02167148
69MP0003786_premature_aging1.00655570
70MP0002734_abnormal_mechanical_nocicepti1.00359609
71MP0004019_abnormal_vitamin_homeostasis1.00234744
72MP0001440_abnormal_grooming_behavior0.99612509
73MP0002064_seizures0.98511022
74MP0009115_abnormal_fat_cell0.95586433
75MP0000778_abnormal_nervous_system0.95383491
76MP0001919_abnormal_reproductive_system0.88514866
77MP0002876_abnormal_thyroid_physiology0.88476313
78MP0003806_abnormal_nucleotide_metabolis0.88269698
79MP0004811_abnormal_neuron_physiology0.87866343
80MP0005266_abnormal_metabolism0.87041962
81MP0008058_abnormal_DNA_repair0.86132325
82MP0003115_abnormal_respiratory_system0.84996997
83MP0008932_abnormal_embryonic_tissue0.84860253
84MP0000569_abnormal_digit_pigmentation0.84048052
85MP0002254_reproductive_system_inflammat0.80567725
86MP0004742_abnormal_vestibular_system0.78664397
87MP0005395_other_phenotype0.78433033
88MP0002272_abnormal_nervous_system0.78399480
89MP0002102_abnormal_ear_morphology0.78189812
90MP0005389_reproductive_system_phenotype0.77163002
91MP0001881_abnormal_mammary_gland0.77088388
92MP0005464_abnormal_platelet_physiology0.76007116
93MP0002557_abnormal_social/conspecific_i0.75355254
94MP0000955_abnormal_spinal_cord0.74709299
95MP0003787_abnormal_imprinting0.73826774
96MP0002067_abnormal_sensory_capabilities0.73629815
97MP0005375_adipose_tissue_phenotype0.72747561
98MP0005646_abnormal_pituitary_gland0.72570553
99MP0005423_abnormal_somatic_nervous0.72145875
100MP0002970_abnormal_white_adipose0.71670896
101MP0005379_endocrine/exocrine_gland_phen0.71110909
102MP0009765_abnormal_xenobiotic_induced0.70714875
103MP0002152_abnormal_brain_morphology0.70061301
104MP0000609_abnormal_liver_physiology0.70017997
105MP0000639_abnormal_adrenal_gland0.68457167
106MP0006276_abnormal_autonomic_nervous0.66089060
107MP0001186_pigmentation_phenotype0.65850323
108MP0003879_abnormal_hair_cell0.65503388
109MP0005253_abnormal_eye_physiology0.65249889
110MP0005332_abnormal_amino_acid0.64909052
111MP0004215_abnormal_myocardial_fiber0.64409211
112MP0002295_abnormal_pulmonary_circulatio0.64270211
113MP0003861_abnormal_nervous_system0.64238367
114MP0003011_delayed_dark_adaptation0.63591946
115MP0002971_abnormal_brown_adipose0.63580218
116MP0008872_abnormal_physiological_respon0.63511293
117MP0008770_decreased_survivor_rate0.62907175
118MP0000631_abnormal_neuroendocrine_gland0.61774325
119MP0004185_abnormal_adipocyte_glucose0.61672066
120MP0005310_abnormal_salivary_gland0.61369477
121MP0008569_lethality_at_weaning0.61297776
122MP0002928_abnormal_bile_duct0.59791398
123MP0006035_abnormal_mitochondrial_morpho0.59511824
124MP0002882_abnormal_neuron_morphology0.59372466
125MP0005275_abnormal_skin_tensile0.58551428
126MP0004885_abnormal_endolymph0.57976533
127MP0002909_abnormal_adrenal_gland0.56930530
128MP0002938_white_spotting0.56776204
129MP0001324_abnormal_eye_pigmentation0.56246565
130MP0000358_abnormal_cell_content/0.56138965
131MP0006072_abnormal_retinal_apoptosis0.56078728
132MP0000462_abnormal_digestive_system0.55607375
133MP0004142_abnormal_muscle_tone0.55307140
134MP0001119_abnormal_female_reproductive0.55145747
135MP0001672_abnormal_embryogenesis/_devel0.54947699
136MP0005380_embryogenesis_phenotype0.54947699
137MP0001764_abnormal_homeostasis0.53604543
138MP0002139_abnormal_hepatobiliary_system0.52986777
139MP0002184_abnormal_innervation0.51936754
140MP0009697_abnormal_copulation0.50233205
141MP0004133_heterotaxia0.49043630
142MP0003633_abnormal_nervous_system0.48946118
143MP0002163_abnormal_gland_morphology0.47788685
144MP0002693_abnormal_pancreas_physiology0.47786793
145MP0002066_abnormal_motor_capabilities/c0.47227249
146MP0002837_dystrophic_cardiac_calcinosis0.46496841
147MP0001963_abnormal_hearing_physiology0.46221945
148MP0005636_abnormal_mineral_homeostasis0.45714506
149MP0002752_abnormal_somatic_nervous0.44595960
150MP0005386_behavior/neurological_phenoty0.43194305
151MP0004924_abnormal_behavior0.43194305
152MP0005365_abnormal_bile_salt0.42513097
153MP0004085_abnormal_heartbeat0.42030248
154MP0003699_abnormal_female_reproductive0.41590019
155MP0003631_nervous_system_phenotype0.40941820
156MP0002733_abnormal_thermal_nociception0.39895412
157MP0000026_abnormal_inner_ear0.39588011
158MP0002229_neurodegeneration0.38778946
159MP0005535_abnormal_body_temperature0.38679741
160MP0001970_abnormal_pain_threshold0.38614520
161MP0003942_abnormal_urinary_system0.38088619
162MP0001944_abnormal_pancreas_morphology0.37490490
163MP0000013_abnormal_adipose_tissue0.37410077
164MP0003329_amyloid_beta_deposits0.36679240
165MP0000678_abnormal_parathyroid_gland0.36194246
166MP0005195_abnormal_posterior_eye0.36117482
167MP0003656_abnormal_erythrocyte_physiolo0.34478968
168MP0005391_vision/eye_phenotype0.33930582

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.02974129
2Abnormal respiratory motile cilium morphology (HP:0005938)8.48413075
3Abnormal respiratory epithelium morphology (HP:0012253)8.48413075
4Abnormality of the heme biosynthetic pathway (HP:0010472)8.46230462
5Abnormal ciliary motility (HP:0012262)7.53564934
6Rhinitis (HP:0012384)7.12776437
7Poikilocytosis (HP:0004447)6.93958409
8Chronic bronchitis (HP:0004469)6.67091770
9Infertility (HP:0000789)6.07984392
10Nasal polyposis (HP:0100582)5.59713427
11Reticulocytosis (HP:0001923)5.57004782
12Long clavicles (HP:0000890)5.09080861
13Abnormality of the nasal mucosa (HP:0000433)4.42100443
14Male infertility (HP:0003251)3.92903572
15Nephronophthisis (HP:0000090)3.92854031
16Abnormality of the labia minora (HP:0012880)3.90960098
17Medial flaring of the eyebrow (HP:0010747)3.87275484
18Bronchitis (HP:0012387)3.82493965
19Bronchiectasis (HP:0002110)3.76100515
20Aplasia/Hypoplasia of the sternum (HP:0006714)3.55720350
21Abnormal number of erythroid precursors (HP:0012131)3.49049357
22Abnormal hemoglobin (HP:0011902)3.48769650
23Short phalanx of the thumb (HP:0009660)3.47946132
24Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.45795824
25Short 1st metacarpal (HP:0010034)3.45795824
26Abnormality of reticulocytes (HP:0004312)3.42810440
27Cholelithiasis (HP:0001081)3.39064439
28Hypochromic microcytic anemia (HP:0004840)3.30968264
29Severe visual impairment (HP:0001141)3.18944500
30Ileus (HP:0002595)3.12112715
31Acanthocytosis (HP:0001927)3.07862840
32Abnormal gallbladder morphology (HP:0012437)3.05410891
33Paralysis (HP:0003470)3.05252838
34Abnormality of the renal medulla (HP:0100957)3.03465138
35Abnormality of the 1st metacarpal (HP:0010009)2.99456661
36Abnormal spermatogenesis (HP:0008669)2.98240514
37Recurrent sinusitis (HP:0011108)2.97502037
38Hepatoblastoma (HP:0002884)2.96113223
39Abnormality of midbrain morphology (HP:0002418)2.82194094
40Molar tooth sign on MRI (HP:0002419)2.82194094
41Increased density of long bones (HP:0006392)2.77707707
42Gait imbalance (HP:0002141)2.75759133
43Facial hemangioma (HP:0000329)2.73936863
44Chromsome breakage (HP:0040012)2.71365804
45Congenital primary aphakia (HP:0007707)2.68681696
46Recurrent otitis media (HP:0000403)2.68463300
47Adactyly (HP:0009776)2.63599224
48Abnormality of chromosome stability (HP:0003220)2.57656001
49Aplasia/Hypoplasia of the earlobes (HP:0009906)2.57194929
50Abnormality of cells of the erythroid lineage (HP:0012130)2.55227553
51Methylmalonic acidemia (HP:0002912)2.53262673
52Hypoplastic labia majora (HP:0000059)2.47435837
53Alacrima (HP:0000522)2.43282823
54Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.39429517
55Peripheral hypomyelination (HP:0007182)2.36188323
56Diaphragmatic weakness (HP:0009113)2.36070603
57Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.35530343
58Hyperbilirubinemia (HP:0002904)2.33269697
59Spinal muscular atrophy (HP:0007269)2.31665917
60Tubulointerstitial nephritis (HP:0001970)2.30437249
61Microcytic anemia (HP:0001935)2.29554480
62Tubulointerstitial abnormality (HP:0001969)2.29505182
63Nephrogenic diabetes insipidus (HP:0009806)2.28167092
64Broad ribs (HP:0000885)2.26522053
65Genital tract atresia (HP:0001827)2.25951063
66Metaphyseal dysplasia (HP:0100255)2.24761048
67Macroorchidism (HP:0000053)2.23396432
68Abnormality of the lower motor neuron (HP:0002366)2.22498054
69Ankle contracture (HP:0006466)2.18550135
70Microglossia (HP:0000171)2.18136951
71Abnormality of the labia majora (HP:0012881)2.18049567
72Aplasia/Hypoplasia of the lens (HP:0008063)2.17458738
73Abnormality of homocysteine metabolism (HP:0010919)2.14703323
74Homocystinuria (HP:0002156)2.14703323
75Tubular atrophy (HP:0000092)2.13953881
76Protruding tongue (HP:0010808)2.11560403
77Redundant skin (HP:0001582)2.10207748
78Tubulointerstitial fibrosis (HP:0005576)2.09657219
79Gonadotropin excess (HP:0000837)2.05526332
80Abnormality of the gallbladder (HP:0005264)2.05406575
81Vaginal atresia (HP:0000148)2.04826477
82Polycythemia (HP:0001901)2.01059785
83Impulsivity (HP:0100710)2.00790752
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.4385655
85Absent/shortened dynein arms (HP:0200106)12.4239505
86Dynein arm defect of respiratory motile cilia (HP:0012255)12.4239505
87Nausea (HP:0002018)1.99962500
88Abnormality of macular pigmentation (HP:0008002)1.99814254
89Opisthotonus (HP:0002179)1.97806226
90Azoospermia (HP:0000027)1.97550951
91Poor coordination (HP:0002370)1.95147737
92Upper limb muscle weakness (HP:0003484)1.93747999
93Decreased lacrimation (HP:0000633)1.93540280
94Recurrent bronchitis (HP:0002837)1.92762095
95Ureteral obstruction (HP:0006000)1.92627433
96Prolonged bleeding time (HP:0003010)1.92578227
97Volvulus (HP:0002580)1.91451453
98Double outlet right ventricle (HP:0001719)1.90987965
99Congenital malformation of the right heart (HP:0011723)1.90987965
100Postaxial hand polydactyly (HP:0001162)1.89229997
101Abnormality of transition element cation homeostasis (HP:0011030)1.87250484
102Amyotrophic lateral sclerosis (HP:0007354)1.87039839
103Neoplasm of the heart (HP:0100544)1.84399606
104Heterotopia (HP:0002282)1.83252205
105Postaxial foot polydactyly (HP:0001830)1.82371865
106Hyperventilation (HP:0002883)1.81350585
107Abnormality of the renal cortex (HP:0011035)1.80061824
108Aplasia/Hypoplasia of the nipples (HP:0006709)1.78788937
109Abnormal rod and cone electroretinograms (HP:0008323)1.78389507
110Visual hallucinations (HP:0002367)1.77425303
111Small hand (HP:0200055)1.77391497
112High pitched voice (HP:0001620)1.75649174
113Fibular hypoplasia (HP:0003038)1.73996485
114Acute encephalopathy (HP:0006846)1.73617816
115Focal motor seizures (HP:0011153)1.73274026
116Abnormality of the fingertips (HP:0001211)1.72838205
117Hypoplastic nipples (HP:0002557)1.71606500
118Hypoparathyroidism (HP:0000829)1.70512815
119Postnatal microcephaly (HP:0005484)1.70111273
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.69569108
121Generalized myoclonic seizures (HP:0002123)1.69245897
122Dyschromatopsia (HP:0007641)1.68154719
123Abnormal gallbladder physiology (HP:0012438)1.68083096
124Cholecystitis (HP:0001082)1.68083096
125Pancreatic fibrosis (HP:0100732)1.68028551
126Decreased central vision (HP:0007663)1.67897347
127Hypochromic anemia (HP:0001931)1.66364476
128Decreased skull ossification (HP:0004331)1.66105254
129Absent eyebrow (HP:0002223)1.65820393
130Hand muscle atrophy (HP:0009130)1.65433765
131Abnormality of saccadic eye movements (HP:0000570)1.65103734
132Congenital hepatic fibrosis (HP:0002612)1.64156114
133Orthostatic hypotension (HP:0001278)1.64101453
134Hypothermia (HP:0002045)1.63913781
135Patchy hypopigmentation of hair (HP:0011365)1.63403736
136Abnormal drinking behavior (HP:0030082)1.62884125
137Polydipsia (HP:0001959)1.62884125
138Sloping forehead (HP:0000340)1.62882462
139Renal dysplasia (HP:0000110)1.62389428
140Long foot (HP:0001833)1.62370185
141Small intestinal stenosis (HP:0012848)1.62217636
142Duodenal stenosis (HP:0100867)1.62217636
143Bicornuate uterus (HP:0000813)1.61820223
144Chronic hepatic failure (HP:0100626)1.61417042
145Chronic sinusitis (HP:0011109)1.60604331
146Optic nerve hypoplasia (HP:0000609)1.59692114
147Cortical dysplasia (HP:0002539)1.59357778
148Labial hypoplasia (HP:0000066)1.58762390
149Aplasia/Hypoplasia of the tongue (HP:0010295)1.58208526
150Abnormality of the vitamin B12 metabolism (HP:0004341)1.58070460
151Impaired vibration sensation in the lower limbs (HP:0002166)1.57590181
152Choroideremia (HP:0001139)1.56941155
153Abnormality of iron homeostasis (HP:0011031)1.56815545
154Stage 5 chronic kidney disease (HP:0003774)1.56210008
155Progressive cerebellar ataxia (HP:0002073)1.55507471
156Short thumb (HP:0009778)1.54751999
157Acute necrotizing encephalopathy (HP:0006965)1.54513445
158Microvesicular hepatic steatosis (HP:0001414)1.54411268
159Facial cleft (HP:0002006)1.54250901
160Truncal obesity (HP:0001956)1.53740831
161White forelock (HP:0002211)1.53293599
162Abnormal biliary tract physiology (HP:0012439)1.52467739
163Bile duct proliferation (HP:0001408)1.52467739
164Type I transferrin isoform profile (HP:0003642)1.52411913
165Epileptic encephalopathy (HP:0200134)1.51025845
166Median cleft lip (HP:0000161)1.50979560
167Abnormality of renal excretion (HP:0011036)1.50205049
168Increased serum pyruvate (HP:0003542)1.49140451
169Hyperlipoproteinemia (HP:0010980)1.48770552
170Hypoplastic female external genitalia (HP:0012815)1.48635931
171Abnormality of ocular smooth pursuit (HP:0000617)1.48607478
172Abnormality of the dental root (HP:0006486)1.47874283
173Taurodontia (HP:0000679)1.47874283
174Abnormality of permanent molar morphology (HP:0011071)1.47874283
175Oculomotor apraxia (HP:0000657)1.46492318
176Deformed sella turcica (HP:0002681)1.46109521
177Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.45430332
178Absent frontal sinuses (HP:0002688)1.45296619
179Short ribs (HP:0000773)1.45054775
180Inability to walk (HP:0002540)1.44389703
181Hypoplasia of the capital femoral epiphysis (HP:0003090)1.38130795
182Delayed gross motor development (HP:0002194)1.38124992
183Abnormality of the dental pulp (HP:0006479)1.37402787
184Pachygyria (HP:0001302)1.36949759
185Abnormality of molar (HP:0011077)1.36639540
186Abnormality of molar morphology (HP:0011070)1.36639540
187Broad foot (HP:0001769)1.36194657
188J-shaped sella turcica (HP:0002680)1.35225058
189Spastic tetraparesis (HP:0001285)1.34641627
190Gaze-evoked nystagmus (HP:0000640)1.32126839
191Retinitis pigmentosa (HP:0000510)1.31925944
192Impaired smooth pursuit (HP:0007772)1.30836167
193Constricted visual fields (HP:0001133)1.29311457
194Progressive inability to walk (HP:0002505)1.27346955
195Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.27250647
196Papillary thyroid carcinoma (HP:0002895)1.25728422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.69081254
2PDK37.69081254
3MAP4K25.38964541
4CLK14.89086744
5PRKD34.78375626
6PDK24.74137626
7TESK14.67715156
8EIF2AK14.64661005
9ICK2.84489484
10PLK42.79821711
11TXK2.72316199
12PNCK2.69340029
13PTK2B2.36942322
14CAMK1D2.19993486
15STK392.14840070
16KSR12.08847140
17WNK42.07690035
18TAOK22.04424096
19STK381.96280272
20MAP2K61.81726302
21EEF2K1.66806017
22TRPM71.58292224
23NEK11.50960362
24BMPR21.48081847
25MAPKAPK31.46180808
26PDK11.42288335
27ERBB31.40594812
28STK38L1.38783444
29DYRK1B1.38360058
30PIM11.31488206
31WNK11.29210061
32MST41.21192010
33TRIM281.14256992
34CCNB11.09503335
35MARK11.07363278
36MUSK1.06687943
37NEK21.05077812
38PDPK11.01765258
39STK40.98849125
40NTRK30.97997094
41TYRO30.96611307
42MAP2K70.92396959
43ADRBK20.91692016
44EIF2AK30.87302387
45EPHA40.85579265
46MAP3K40.85062871
47NME10.84007370
48TEC0.83679189
49MAP3K50.80382926
50FRK0.79586514
51PRKAA20.79536789
52NEK60.79074625
53BMX0.77730356
54ZAK0.75668318
55BUB10.75516324
56MKNK20.72910455
57MAPK110.72745184
58ILK0.71363691
59BRSK20.71245284
60VRK10.70827393
61MINK10.69898962
62PRKCG0.69684313
63PIM20.69592423
64MAPK120.69209444
65RIPK40.66313243
66MAP2K10.65603798
67MAPKAPK50.63962621
68NUAK10.63941914
69CHEK20.63785252
70PINK10.62920638
71RPS6KB20.60676617
72NTRK20.59940718
73PRKCI0.58230149
74PKN20.58125049
75CASK0.54900485
76BRSK10.51814310
77TAOK30.51414176
78STK160.50011432
79JAK20.49214575
80CAMK1G0.48037429
81DYRK30.47939866
82PBK0.47651856
83RPS6KA50.46771982
84MAP2K40.46352117
85GRK50.45884791
86CAMK2A0.45743289
87RAF10.43947154
88SGK20.42796200
89SIK20.42203617
90PLK20.41940294
91WEE10.41697587
92CDC70.41324885
93PKN10.40817636
94TTK0.40224311
95OXSR10.38725557
96SIK30.38712980
97IRAK10.37910053
98CDK10.37713577
99SGK2230.37640767
100SGK4940.37640767
101STK30.37188741
102CDK30.36597492
103CAMK10.36406861
104PASK0.35972477
105FER0.35253569
106CDK90.35176261
107CDK150.34777833
108CDK180.34470411
109LMTK20.34114524
110SRPK10.32441136
111RPS6KB10.32073381
112CDK140.31639283
113MARK30.31600855
114ATM0.31441172
115STK100.31332301
116LIMK10.31221386
117PAK60.30275155
118BMPR1B0.29938697
119CDK50.29666714
120MKNK10.28334161
121SCYL20.27607791
122PIK3CG0.27127087
123CSNK1D0.26891330
124CHEK10.26890307
125MAPK130.25980227
126MAPK40.25869313
127CAMKK10.25724812
128GRK70.25693193
129MAP3K20.25287455
130CDK20.25269179
131CDK11A0.25173155
132MAPK150.25002355
133PRKCZ0.24949837
134TAF10.24595253
135BCR0.22587934
136PRKG10.21527629
137PRKCE0.21209059
138WNK30.20738650
139PLK30.20711983
140PRKCB0.20389591
141PLK10.20002234
142ERBB40.17269258
143GSK3B0.16748403
144STK110.16584353
145MAPK80.16281002
146DYRK20.16091427
147PRKCQ0.15818272
148AKT30.15044221
149SGK30.14576866
150PRKACA0.14525416
151ACVR1B0.14455088
152NTRK10.13139955
153PRKACG0.12566664
154YES10.12097499
155PRKAA10.11680065
156CAMKK20.11506856
157ATR0.11420775
158CAMK2B0.10672202

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.85622707
2Fatty acid biosynthesis_Homo sapiens_hsa000613.31558491
3Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.16837441
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.01719807
5Butanoate metabolism_Homo sapiens_hsa006502.98121947
6Homologous recombination_Homo sapiens_hsa034402.98046998
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95551240
8Pyruvate metabolism_Homo sapiens_hsa006202.77067805
9Amphetamine addiction_Homo sapiens_hsa050312.66455881
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.63263612
11Mismatch repair_Homo sapiens_hsa034302.62035448
12Glucagon signaling pathway_Homo sapiens_hsa049222.52978696
13Propanoate metabolism_Homo sapiens_hsa006402.47062463
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.38757399
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38239768
16One carbon pool by folate_Homo sapiens_hsa006702.28999769
17Nucleotide excision repair_Homo sapiens_hsa034202.16318900
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13383787
19Nicotine addiction_Homo sapiens_hsa050332.11528286
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08649903
21Linoleic acid metabolism_Homo sapiens_hsa005912.07663183
22Oocyte meiosis_Homo sapiens_hsa041141.99736392
23Nitrogen metabolism_Homo sapiens_hsa009101.95510450
24Basal transcription factors_Homo sapiens_hsa030221.94139469
25Long-term potentiation_Homo sapiens_hsa047201.92270763
26Dorso-ventral axis formation_Homo sapiens_hsa043201.90340111
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80111524
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75335608
29Cell cycle_Homo sapiens_hsa041101.67782958
30Insulin secretion_Homo sapiens_hsa049111.67761779
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.62776448
32N-Glycan biosynthesis_Homo sapiens_hsa005101.62684381
33Renin secretion_Homo sapiens_hsa049241.59052078
34DNA replication_Homo sapiens_hsa030301.58011269
35Cardiac muscle contraction_Homo sapiens_hsa042601.56221009
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54160233
37Selenocompound metabolism_Homo sapiens_hsa004501.53541684
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52905401
39Circadian entrainment_Homo sapiens_hsa047131.47532898
40Collecting duct acid secretion_Homo sapiens_hsa049661.46169270
41Synaptic vesicle cycle_Homo sapiens_hsa047211.46112243
42Glycerolipid metabolism_Homo sapiens_hsa005611.45002776
43Cocaine addiction_Homo sapiens_hsa050301.44339877
44Huntingtons disease_Homo sapiens_hsa050161.43109414
45PPAR signaling pathway_Homo sapiens_hsa033201.40136447
46RNA transport_Homo sapiens_hsa030131.40131733
47Taste transduction_Homo sapiens_hsa047421.39805442
48Pentose phosphate pathway_Homo sapiens_hsa000301.36457023
49Fatty acid elongation_Homo sapiens_hsa000621.31950881
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29401831
51Salivary secretion_Homo sapiens_hsa049701.27288246
52Glutamatergic synapse_Homo sapiens_hsa047241.26335860
53Dopaminergic synapse_Homo sapiens_hsa047281.25393440
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23257464
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21143149
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18250933
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17661118
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.17177318
59Protein export_Homo sapiens_hsa030601.14065319
60Mineral absorption_Homo sapiens_hsa049781.12741602
61Peroxisome_Homo sapiens_hsa041461.11442303
62Folate biosynthesis_Homo sapiens_hsa007901.11032645
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10923191
64Calcium signaling pathway_Homo sapiens_hsa040201.07705770
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07112191
66Fanconi anemia pathway_Homo sapiens_hsa034601.02834408
67Glycerophospholipid metabolism_Homo sapiens_hsa005641.02827283
68cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02081900
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01645189
70Fat digestion and absorption_Homo sapiens_hsa049751.01148087
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98926948
72Pancreatic secretion_Homo sapiens_hsa049720.97360644
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.96634632
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96437909
75Gastric acid secretion_Homo sapiens_hsa049710.95875857
76Morphine addiction_Homo sapiens_hsa050320.95703465
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.95351794
78Base excision repair_Homo sapiens_hsa034100.93888533
79Long-term depression_Homo sapiens_hsa047300.93481135
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92402431
81Estrogen signaling pathway_Homo sapiens_hsa049150.92069564
82Ether lipid metabolism_Homo sapiens_hsa005650.91497866
83Thyroid hormone synthesis_Homo sapiens_hsa049180.89856385
84Pyrimidine metabolism_Homo sapiens_hsa002400.87952589
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87166279
86Carbon metabolism_Homo sapiens_hsa012000.85872306
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85476351
88Fatty acid metabolism_Homo sapiens_hsa012120.81456172
89Metabolic pathways_Homo sapiens_hsa011000.80027430
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79409568
91Olfactory transduction_Homo sapiens_hsa047400.77861975
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75752964
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74610367
94Spliceosome_Homo sapiens_hsa030400.73309414
95Fatty acid degradation_Homo sapiens_hsa000710.70558888
96GABAergic synapse_Homo sapiens_hsa047270.70019681
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.68783456
98Steroid biosynthesis_Homo sapiens_hsa001000.68776624
99Bile secretion_Homo sapiens_hsa049760.68304302
100Fructose and mannose metabolism_Homo sapiens_hsa000510.67760219
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67672404
102Sphingolipid metabolism_Homo sapiens_hsa006000.67557986
103Proteasome_Homo sapiens_hsa030500.67391906
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67063778
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66683449
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66609414
107Tryptophan metabolism_Homo sapiens_hsa003800.65520550
108Glutathione metabolism_Homo sapiens_hsa004800.64766892
109cAMP signaling pathway_Homo sapiens_hsa040240.64703167
110Regulation of autophagy_Homo sapiens_hsa041400.61573814
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60053011
112mRNA surveillance pathway_Homo sapiens_hsa030150.59929765
113Biosynthesis of amino acids_Homo sapiens_hsa012300.59272205
114p53 signaling pathway_Homo sapiens_hsa041150.59036816
115Hedgehog signaling pathway_Homo sapiens_hsa043400.57622336
116Renin-angiotensin system_Homo sapiens_hsa046140.57247183
117Purine metabolism_Homo sapiens_hsa002300.56974336
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55304622
119Oxytocin signaling pathway_Homo sapiens_hsa049210.53967449
120Sulfur metabolism_Homo sapiens_hsa009200.50278424
121Serotonergic synapse_Homo sapiens_hsa047260.50184112
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50042086
123AMPK signaling pathway_Homo sapiens_hsa041520.47520079
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47311089
125Vitamin digestion and absorption_Homo sapiens_hsa049770.46580090
126Protein digestion and absorption_Homo sapiens_hsa049740.43675678
127Alzheimers disease_Homo sapiens_hsa050100.41963644
128Alcoholism_Homo sapiens_hsa050340.41066532
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40841265
130Viral carcinogenesis_Homo sapiens_hsa052030.40677674
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40178068
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39824588
133Cholinergic synapse_Homo sapiens_hsa047250.39343898
134Non-homologous end-joining_Homo sapiens_hsa034500.38933532
135ABC transporters_Homo sapiens_hsa020100.38507998
136Circadian rhythm_Homo sapiens_hsa047100.38191532
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.38017912
138Gap junction_Homo sapiens_hsa045400.36619069
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.36530889
140Inositol phosphate metabolism_Homo sapiens_hsa005620.35573272
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35466512
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.34335912
143Vibrio cholerae infection_Homo sapiens_hsa051100.33464406
144Wnt signaling pathway_Homo sapiens_hsa043100.33185744
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33142824
146Type II diabetes mellitus_Homo sapiens_hsa049300.32649688
147Oxidative phosphorylation_Homo sapiens_hsa001900.31772457
148Parkinsons disease_Homo sapiens_hsa050120.31623589
149Phototransduction_Homo sapiens_hsa047440.31362706
150Melanogenesis_Homo sapiens_hsa049160.30715001
151RNA polymerase_Homo sapiens_hsa030200.30499760
152TGF-beta signaling pathway_Homo sapiens_hsa043500.27347988
153RNA degradation_Homo sapiens_hsa030180.23981614
154Melanoma_Homo sapiens_hsa052180.21371100

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