SPATC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)9.71437221
2epithelial cilium movement (GO:0003351)9.65183022
3binding of sperm to zona pellucida (GO:0007339)9.38688467
4cell-cell recognition (GO:0009988)9.14737376
5regulation of cilium movement (GO:0003352)9.13014996
6axonemal dynein complex assembly (GO:0070286)9.11320166
7multicellular organism reproduction (GO:0032504)9.02795726
8spermatid development (GO:0007286)8.90526029
9motile cilium assembly (GO:0044458)8.53746473
10plasma membrane fusion (GO:0045026)8.50409263
11reproduction (GO:0000003)7.87605863
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.64488075
13cilium movement (GO:0003341)7.48138358
14negative regulation of inclusion body assembly (GO:0090084)6.69139527
15cilium or flagellum-dependent cell motility (GO:0001539)6.59341830
16spermatogenesis (GO:0007283)6.43761675
17male gamete generation (GO:0048232)6.41232669
18organic cation transport (GO:0015695)6.37936646
19sperm capacitation (GO:0048240)6.35138477
20rRNA methylation (GO:0031167)6.34898715
21phosphatidylethanolamine biosynthetic process (GO:0006646)6.30933554
22synaptonemal complex organization (GO:0070193)6.30648321
23single fertilization (GO:0007338)6.18020284
24synaptonemal complex assembly (GO:0007130)6.06502873
25protein targeting to Golgi (GO:0000042)6.02828286
26gamete generation (GO:0007276)5.91343353
27microtubule depolymerization (GO:0007019)5.82208561
28piRNA metabolic process (GO:0034587)5.81483880
29establishment of protein localization to Golgi (GO:0072600)5.76567157
30phosphatidylethanolamine metabolic process (GO:0046337)5.75002799
31male meiosis (GO:0007140)5.74138410
32glycerol ether metabolic process (GO:0006662)5.73647098
33retrograde transport, vesicle recycling within Golgi (GO:0000301)5.68574742
34proline biosynthetic process (GO:0006561)5.67471247
35regulation of inclusion body assembly (GO:0090083)5.64682403
36fertilization (GO:0009566)5.64319360
37regulation of microtubule-based movement (GO:0060632)5.37909460
38chromosome condensation (GO:0030261)5.29292202
39ether metabolic process (GO:0018904)5.28027870
40germ cell development (GO:0007281)5.12025321
41rRNA modification (GO:0000154)5.07810706
42DNA packaging (GO:0006323)4.96058488
43cellular process involved in reproduction in multicellular organism (GO:0022412)4.92237820
44single strand break repair (GO:0000012)4.86277129
45calcium ion-dependent exocytosis (GO:0017156)4.75462429
46response to pheromone (GO:0019236)4.68164552
47multicellular organismal reproductive process (GO:0048609)4.66992703
48regulation of T-helper 2 cell differentiation (GO:0045628)4.50038982
49centriole replication (GO:0007099)4.48328241
50ventricular system development (GO:0021591)4.44918100
51centriole assembly (GO:0098534)4.34039798
52regulation of Rab GTPase activity (GO:0032313)4.30634932
53positive regulation of Rab GTPase activity (GO:0032851)4.30634932
54protein localization to Golgi apparatus (GO:0034067)4.25619935
55proline metabolic process (GO:0006560)4.21571602
56spermatid nucleus differentiation (GO:0007289)4.20588193
57cell recognition (GO:0008037)4.18888553
58regulation of spindle checkpoint (GO:0090231)4.09039303
59seminiferous tubule development (GO:0072520)4.07690726
60microtubule severing (GO:0051013)4.05794391
61left/right pattern formation (GO:0060972)4.03705991
62chromosome organization involved in meiosis (GO:0070192)3.94896060
63male meiosis I (GO:0007141)3.94730925
64sexual reproduction (GO:0019953)3.84441343
65protein polyglutamylation (GO:0018095)3.81022049
66sequestering of actin monomers (GO:0042989)3.74119519
67multicellular organismal development (GO:0007275)3.73839338
68positive regulation of type 2 immune response (GO:0002830)3.71031232
69meiotic nuclear division (GO:0007126)3.70616565
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.66761934
71DNA deamination (GO:0045006)3.55933249
72DNA methylation involved in gamete generation (GO:0043046)3.53731717
73genitalia morphogenesis (GO:0035112)3.53543343
74chaperone-mediated protein complex assembly (GO:0051131)3.52819538
75regulation of centriole replication (GO:0046599)3.48031059
76macrophage activation involved in immune response (GO:0002281)3.46154663
77membrane protein intracellular domain proteolysis (GO:0031293)3.41743235
78interferon-gamma secretion (GO:0072643)3.30121342
79peptide catabolic process (GO:0043171)3.29559793
80multicellular organismal movement (GO:0050879)3.26974572
81musculoskeletal movement (GO:0050881)3.26974572
82carnitine transport (GO:0015879)3.23858005
83amino-acid betaine transport (GO:0015838)3.23858005
84RNA localization (GO:0006403)3.22084943
85response to peptidoglycan (GO:0032494)3.21901999
86regulation of interferon-beta biosynthetic process (GO:0045357)3.20932079
87cellular ketone body metabolic process (GO:0046950)3.20014926
88regulation of podosome assembly (GO:0071801)3.19731786
89positive regulation of T-helper cell differentiation (GO:0045624)3.12070791
90transcription from mitochondrial promoter (GO:0006390)3.11529306
91regulation of transcription involved in cell fate commitment (GO:0060850)3.11283389
92microtubule nucleation (GO:0007020)3.07582184
93response to muramyl dipeptide (GO:0032495)3.07476491
94meiosis I (GO:0007127)3.07207090
95RNA destabilization (GO:0050779)3.06789880
96carnitine transmembrane transport (GO:1902603)3.05344910
97regulation of ARF GTPase activity (GO:0032312)3.01332308
98mitochondrion degradation (GO:0000422)3.01130332
99meiotic cell cycle (GO:0051321)3.00428202
100positive regulation by symbiont of host defense response (GO:0052509)2.97285802
101modulation by symbiont of host defense response (GO:0052031)2.97285802
102modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97285802
103modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97285802
104positive regulation by organism of defense response of other organism involved in symbiotic interact2.97285802
105modulation by symbiont of host immune response (GO:0052553)2.97285802
106embryonic process involved in female pregnancy (GO:0060136)2.97032377
107establishment of apical/basal cell polarity (GO:0035089)2.90178922
108myeloid cell activation involved in immune response (GO:0002275)2.89200871
109response to acidic pH (GO:0010447)2.88026825
110negative regulation of Rho protein signal transduction (GO:0035024)2.84558153
111lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83420768
112glycolytic process (GO:0006096)2.79956129
113negative regulation of granulocyte differentiation (GO:0030853)2.78825863
114positive regulation of protein homooligomerization (GO:0032464)2.76940355
115microtubule polymerization or depolymerization (GO:0031109)2.75074773
116nucleus organization (GO:0006997)2.74004992
117ketone body metabolic process (GO:1902224)2.73986495
118positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.71743688
119axoneme assembly (GO:0035082)2.71451949
120positive regulation of macrophage activation (GO:0043032)2.69493778
121leukocyte degranulation (GO:0043299)2.68150855
122cellular response to pH (GO:0071467)2.68027840
123meiotic cell cycle process (GO:1903046)2.67498216
124polyamine biosynthetic process (GO:0006596)2.65742720
125protein K11-linked deubiquitination (GO:0035871)2.65312000
126peptidyl-threonine dephosphorylation (GO:0035970)2.64416227
127adenosine receptor signaling pathway (GO:0001973)2.64046980
128regulated secretory pathway (GO:0045055)2.63189611
129glomerular visceral epithelial cell development (GO:0072015)2.62588853
130chromatin silencing (GO:0006342)2.60852979
131protein refolding (GO:0042026)2.59168832
132sex differentiation (GO:0007548)2.57895901
133regulation of T-helper cell differentiation (GO:0045622)2.57694373
134regulation of RNA export from nucleus (GO:0046831)2.56830992
135negative regulation of interleukin-12 production (GO:0032695)2.54952237
136regulation of mast cell degranulation (GO:0043304)2.53853809
137regulation of cilium assembly (GO:1902017)2.53499722
138mast cell degranulation (GO:0043303)2.52936918
139mast cell activation involved in immune response (GO:0002279)2.52936918
140oxidative demethylation (GO:0070989)2.51849312
141germinal center formation (GO:0002467)2.51392852
142mitotic sister chromatid cohesion (GO:0007064)2.51171746
143peptidyl-glutamic acid modification (GO:0018200)2.50586030
144regulation of cell cycle checkpoint (GO:1901976)2.49832198
145regulation of interleukin-13 production (GO:0032656)2.49627410
146replication fork processing (GO:0031297)2.46406370
147establishment or maintenance of monopolar cell polarity (GO:0061339)2.45790466
148establishment of monopolar cell polarity (GO:0061162)2.45790466
149regulation of protein homooligomerization (GO:0032462)2.43031324
150polyol catabolic process (GO:0046174)2.41134081
151sperm motility (GO:0030317)12.9305725
152cell wall macromolecule metabolic process (GO:0044036)11.5191631
153cell wall macromolecule catabolic process (GO:0016998)11.5191631
154fusion of sperm to egg plasma membrane (GO:0007342)11.3474245
155acrosome reaction (GO:0007340)11.3443094
156sperm-egg recognition (GO:0035036)10.2495804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.25070728
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.10407708
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.34339253
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.12053166
5EZH2_22144423_ChIP-Seq_EOC_Human2.69211096
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.53108244
7* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.51028171
8* P68_20966046_ChIP-Seq_HELA_Human2.40682334
9VDR_22108803_ChIP-Seq_LS180_Human2.37828857
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.34954846
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33573142
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32048099
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23437843
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.23216270
15FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20265688
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.11190908
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.03164131
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02454825
19FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.00314396
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.99673046
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97806121
22TET1_21451524_ChIP-Seq_MESCs_Mouse1.93406123
23VDR_21846776_ChIP-Seq_THP-1_Human1.92631402
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.88808742
25SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88263169
26RXRA_24833708_ChIP-Seq_LIVER_Mouse1.85193234
27VDR_24763502_ChIP-Seq_THP-1_Human1.83068834
28ERA_21632823_ChIP-Seq_H3396_Human1.77153875
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74474974
30* SPI1_26923725_Chip-Seq_HPCs_Mouse1.70578196
31* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.70158540
32MAF_26560356_Chip-Seq_TH2_Human1.69465347
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68115388
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64684795
35* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.62124369
36RARA_24833708_ChIP-Seq_LIVER_Mouse1.61244863
37DROSHA_22980978_ChIP-Seq_HELA_Human1.60912439
38SA1_27219007_Chip-Seq_ERYTHROID_Human1.60047525
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58684280
40SA1_27219007_Chip-Seq_Bcells_Human1.57754302
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56487104
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.56224911
43PU.1_20513432_ChIP-Seq_Bcells_Mouse1.55709276
44RUNX_20019798_ChIP-Seq_JUKART_Human1.55287871
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54887337
46SPI1_23127762_ChIP-Seq_K562_Human1.53583491
47MAF_26560356_Chip-Seq_TH1_Human1.52979093
48TAF2_19829295_ChIP-Seq_ESCs_Human1.52826638
49TCF7_22412390_ChIP-Seq_EML_Mouse1.52498665
50* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.51787221
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51414302
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51398361
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.50622295
54* BCOR_27268052_Chip-Seq_Bcells_Human1.50125486
55PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.49577153
56YY1_22570637_ChIP-Seq_MALME-3M_Human1.47596075
57MYC_27129775_Chip-Seq_CORNEA_Mouse1.46816451
58SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.46340620
59RAD21_21589869_ChIP-Seq_MESCs_Mouse1.45030354
60KDM2B_26808549_Chip-Seq_DND41_Human1.45013411
61SCL_19346495_ChIP-Seq_HPC-7_Human1.43368017
62GATA1_19941826_ChIP-Seq_K562_Human1.43101949
63PHF8_20622854_ChIP-Seq_HELA_Human1.40746322
64* OCT4_20526341_ChIP-Seq_ESCs_Human1.40436150
65NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.39859240
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.39734865
67SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39411098
68CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38865071
69GATA3_21867929_ChIP-Seq_CD8_Mouse1.37397927
70STAT1_17558387_ChIP-Seq_HELA_Human1.37294476
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37106869
72MYC_19829295_ChIP-Seq_ESCs_Human1.37060628
73ZNF274_21170338_ChIP-Seq_K562_Hela1.36685310
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36142221
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36005736
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36005736
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34074816
78CTCF_21964334_Chip-Seq_Bcells_Human1.33293665
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32289079
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32285405
81* BCL6_27268052_Chip-Seq_Bcells_Human1.31288122
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.30481830
83FLI1_21867929_ChIP-Seq_CD8_Mouse1.29001011
84RARB_24833708_ChIP-Seq_LIVER_Mouse1.28629771
85JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.28606314
86UTX_26944678_Chip-Seq_JUKART_Human1.28408578
87LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28327450
88* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.28147508
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27723148
90MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27107876
91TDRD3_21172665_ChIP-Seq_MCF-7_Human1.26146154
92* LXR_22292898_ChIP-Seq_THP-1_Human1.24722712
93VDR_24787735_ChIP-Seq_THP-1_Human1.24070537
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24043657
95GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.23270640
96CTCF_27219007_Chip-Seq_Bcells_Human1.22859220
97GATA3_21867929_ChIP-Seq_TH1_Mouse1.22052696
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.21895823
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21391979
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21374714
101ETS1_21867929_ChIP-Seq_TH2_Mouse1.21304690
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20717789
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19598722
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.18246193
105SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17248109
106ESET_19884257_ChIP-Seq_ESCs_Mouse1.16182864
107E2F1_20622854_ChIP-Seq_HELA_Human1.15593032
108* OCT4_19829295_ChIP-Seq_ESCs_Human1.15409312
109IRF8_27001747_Chip-Seq_BMDM_Mouse1.14999123
110ERG_20517297_ChIP-Seq_VCAP_Human1.14111940
111EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.13604498
112P53_21459846_ChIP-Seq_SAOS-2_Human1.13346922
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13103620
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13043445
115REST_21632747_ChIP-Seq_MESCs_Mouse1.12385443
116RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12356897
117* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12324681
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12283393
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12038937
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09174226
121SOX11_22085726_ChIP-Seq_ESNs_Mouse1.08914206
122CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08314993
123* SMC4_20622854_ChIP-Seq_HELA_Human1.08082844
124CSB_26484114_Chip-Seq_FIBROBLAST_Human1.07739728
125* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07680286
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07304624
127EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07269298
128GF1_26923725_Chip-Seq_HPCs_Mouse1.06989911
129P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06954614
130GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06742592
131CEBPB_22108803_ChIP-Seq_LS180_Human1.06625993
132TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06421016
133MYB_26560356_Chip-Seq_TH2_Human1.05836089
134CTCF_20526341_ChIP-Seq_ESCs_Human1.05270519
135SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04669581
136CBP_20019798_ChIP-Seq_JUKART_Human1.03959383
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03959383
138SPI1_20517297_ChIP-Seq_HL60_Human1.03923683
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02674772
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02631794
141STAT3_18555785_ChIP-Seq_MESCs_Mouse1.02216825
142LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02176132
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01826133
144POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01440690
145GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00357997
146* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98616699
147* KLF4_19829295_ChIP-Seq_ESCs_Human0.98518280
148* TP63_22573176_ChIP-Seq_HFKS_Human0.98133977
149FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97994295
150BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.96744614
151KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96360966
152ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96326460
153SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95603673
154SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95447068
155NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.95358455
156* STAT1_20625510_ChIP-Seq_HELA_Human0.95358271
157GATA1_19941827_ChIP-Seq_MEL_Mouse0.94905890
158* P300_27268052_Chip-Seq_Bcells_Human0.92989976
159PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91254374
160NANOG_20526341_ChIP-Seq_ESCs_Human0.89686168
161CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89284291
162NFYB_21822215_ChIP-Seq_K562_Human0.89199778
163* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89077822
164ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89074584
165* RAC3_21632823_ChIP-Seq_H3396_Human0.88654934

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.26525978
2MP0001929_abnormal_gametogenesis4.86111147
3MP0003878_abnormal_ear_physiology4.23975889
4MP0005377_hearing/vestibular/ear_phenot4.23975889
5MP0008877_abnormal_DNA_methylation3.61318968
6MP0009278_abnormal_bone_marrow3.23369159
7MP0002161_abnormal_fertility/fecundity3.01072921
8MP0003303_peritoneal_inflammation2.93388871
9MP0002210_abnormal_sex_determination2.87835282
10MP0004233_abnormal_muscle_weight2.86183286
11MP0005670_abnormal_white_adipose2.67647163
12MP0005451_abnormal_body_composition2.66743866
13MP0001145_abnormal_male_reproductive2.58663703
14MP0001835_abnormal_antigen_presentation2.55628480
15MP0002653_abnormal_ependyma_morphology2.52778665
16MP0001348_abnormal_lacrimal_gland2.24589717
17MP0005310_abnormal_salivary_gland2.23767615
18MP0008057_abnormal_DNA_replication2.23324394
19MP0000653_abnormal_sex_gland2.15952955
20MP0005423_abnormal_somatic_nervous2.13809108
21MP0009785_altered_susceptibility_to2.06517892
22MP0005410_abnormal_fertilization14.7372994
23MP0004510_myositis1.92992733
24MP0002419_abnormal_innate_immunity1.85624824
25MP0002282_abnormal_trachea_morphology1.84721219
26MP0003724_increased_susceptibility_to1.84530663
27MP0001986_abnormal_taste_sensitivity1.82537363
28MP0002148_abnormal_hypersensitivity_rea1.79410520
29MP0005025_abnormal_response_to1.77575367
30MP0008995_early_reproductive_senescence1.77276323
31MP0002138_abnormal_hepatobiliary_system1.77182527
32MP0001545_abnormal_hematopoietic_system1.72846082
33MP0005397_hematopoietic_system_phenotyp1.72846082
34MP0005000_abnormal_immune_tolerance1.68731404
35MP0002723_abnormal_immune_serum1.62700609
36MP0005167_abnormal_blood-brain_barrier1.61634989
37MP0003879_abnormal_hair_cell1.59942928
38MP0000678_abnormal_parathyroid_gland1.53489348
39MP0001800_abnormal_humoral_immune1.51032483
40MP0002452_abnormal_antigen_presenting1.48780100
41MP0009764_decreased_sensitivity_to1.48642243
42MP0005387_immune_system_phenotype1.45322415
43MP0001790_abnormal_immune_system1.45322415
44MP0005171_absent_coat_pigmentation1.43798983
45MP0001533_abnormal_skeleton_physiology1.35543628
46MP0002009_preneoplasia1.32702596
47MP0005083_abnormal_biliary_tract1.29409759
48MP0004947_skin_inflammation1.27594376
49MP0005671_abnormal_response_to1.23788024
50MP0001819_abnormal_immune_cell1.19383038
51MP0002420_abnormal_adaptive_immunity1.18356410
52MP0003646_muscle_fatigue1.14524845
53MP0008469_abnormal_protein_level1.13464147
54MP0002254_reproductive_system_inflammat1.12964334
55MP0005174_abnormal_tail_pigmentation1.05742246
56MP0004133_heterotaxia1.02764768
57MP0001845_abnormal_inflammatory_respons1.02648993
58MP0001293_anophthalmia1.01360463
59MP0001968_abnormal_touch/_nociception0.99834584
60MP0002160_abnormal_reproductive_system0.99628647
61MP0001873_stomach_inflammation0.98753249
62MP0006072_abnormal_retinal_apoptosis0.97934039
63MP0005379_endocrine/exocrine_gland_phen0.94940582
64MP0002998_abnormal_bone_remodeling0.94578505
65MP0005647_abnormal_sex_gland0.94183685
66MP0000716_abnormal_immune_system0.94101021
67MP0002933_joint_inflammation0.93443347
68MP0002269_muscular_atrophy0.88974742
69MP0008058_abnormal_DNA_repair0.87373736
70MP0002398_abnormal_bone_marrow0.86281991
71MP0001324_abnormal_eye_pigmentation0.85967080
72MP0005535_abnormal_body_temperature0.85960157
73MP0005375_adipose_tissue_phenotype0.85868696
74MP0009115_abnormal_fat_cell0.84724505
75MP0002735_abnormal_chemical_nociception0.84600391
76MP0003786_premature_aging0.83291923
77MP0003300_gastrointestinal_ulcer0.83101306
78MP0005166_decreased_susceptibility_to0.82474531
79MP0010094_abnormal_chromosome_stability0.82448276
80MP0003195_calcinosis0.81192270
81MP0005623_abnormal_meninges_morphology0.80325832
82MP0003656_abnormal_erythrocyte_physiolo0.78836356
83MP0002405_respiratory_system_inflammati0.77366595
84MP0005464_abnormal_platelet_physiology0.76850350
85MP0003183_abnormal_peptide_metabolism0.76321110
86MP0002429_abnormal_blood_cell0.75067679
87MP0003011_delayed_dark_adaptation0.71967676
88MP0003091_abnormal_cell_migration0.71669822
89MP0001764_abnormal_homeostasis0.71637099
90MP0010030_abnormal_orbit_morphology0.71575139
91MP0003115_abnormal_respiratory_system0.69511750
92MP0002139_abnormal_hepatobiliary_system0.69126774
93MP0000015_abnormal_ear_pigmentation0.69049740
94MP0003718_maternal_effect0.68651763
95MP0002722_abnormal_immune_system0.68537115
96MP0003045_fibrosis0.68024801
97MP0005365_abnormal_bile_salt0.67553018
98MP0008874_decreased_physiological_sensi0.67316912
99MP0000249_abnormal_blood_vessel0.66479726
100MP0005076_abnormal_cell_differentiation0.65431666
101MP0003283_abnormal_digestive_organ0.65023000
102MP0001485_abnormal_pinna_reflex0.64859621
103MP0003172_abnormal_lysosome_physiology0.63965078
104MP0001486_abnormal_startle_reflex0.63597614
105MP0005253_abnormal_eye_physiology0.63589682
106MP0006082_CNS_inflammation0.62975022
107MP0003890_abnormal_embryonic-extraembry0.59673728
108MP0000579_abnormal_nail_morphology0.59627592
109MP0003119_abnormal_digestive_system0.59197462
110MP0010155_abnormal_intestine_physiology0.59043066
111MP0000604_amyloidosis0.58715016
112MP0002084_abnormal_developmental_patter0.56560602
113MP0005389_reproductive_system_phenotype0.56143510
114MP0005409_darkened_coat_color0.55964451
115MP0005584_abnormal_enzyme/coenzyme_acti0.55573626
116MP0003699_abnormal_female_reproductive0.55246156
117MP0000689_abnormal_spleen_morphology0.54889070
118MP0001697_abnormal_embryo_size0.54881569
119MP0009046_muscle_twitch0.54683678
120MP0002971_abnormal_brown_adipose0.53776212
121MP0000685_abnormal_immune_system0.53151104
122MP0005666_abnormal_adipose_tissue0.52894228
123MP0005085_abnormal_gallbladder_physiolo0.52864081
124MP0004019_abnormal_vitamin_homeostasis0.52218937
125MP0002796_impaired_skin_barrier0.51875776
126MP0000639_abnormal_adrenal_gland0.50655572
127MP0002086_abnormal_extraembryonic_tissu0.50489451
128MP0003453_abnormal_keratinocyte_physiol0.49663463
129MP0004197_abnormal_fetal_growth/weight/0.49298509
130MP0000462_abnormal_digestive_system0.49178335
131MP0005391_vision/eye_phenotype0.48356953
132MP0005075_abnormal_melanosome_morpholog0.48292020
133MP0003111_abnormal_nucleus_morphology0.47397373
134MP0001765_abnormal_ion_homeostasis0.46326057
135MP0000371_diluted_coat_color0.46205305
136MP0001730_embryonic_growth_arrest0.42856451
137MP0005058_abnormal_lysosome_morphology0.42158456
138MP0001340_abnormal_eyelid_morphology0.41318960
139MP0003633_abnormal_nervous_system0.41147078
140MP0001672_abnormal_embryogenesis/_devel0.40684657
141MP0005380_embryogenesis_phenotype0.40684657
142MP0002249_abnormal_larynx_morphology0.40212199
143MP0002085_abnormal_embryonic_tissue0.40156367
144MP0000470_abnormal_stomach_morphology0.40054754
145MP0000358_abnormal_cell_content/0.37111459
146MP0010307_abnormal_tumor_latency0.35656094
147MP0003436_decreased_susceptibility_to0.34959065
148MP0003448_altered_tumor_morphology0.33307665
149MP0005266_abnormal_metabolism0.33036345
150MP0002932_abnormal_joint_morphology0.32611311
151MP0003942_abnormal_urinary_system0.32316267
152MP0001727_abnormal_embryo_implantation0.32291653
153MP0002970_abnormal_white_adipose0.30478628
154MP0000313_abnormal_cell_death0.30457924
155MP0001984_abnormal_olfaction0.29860291
156MP0010630_abnormal_cardiac_muscle0.29836389
157MP0003075_altered_response_to0.28876378
158MP0002080_prenatal_lethality0.28468585
159MP0002928_abnormal_bile_duct0.28245547
160MP0005319_abnormal_enzyme/_coenzyme0.27855546
161MP0000534_abnormal_ureter_morphology0.27589864
162MP0003806_abnormal_nucleotide_metabolis0.27583875
163MP0001119_abnormal_female_reproductive0.27452854
164MP0003936_abnormal_reproductive_system0.27054401
165MP0002019_abnormal_tumor_incidence0.26716481
166MP0002132_abnormal_respiratory_system0.25960290

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.28331772
2Abnormal respiratory motile cilium morphology (HP:0005938)9.28331772
3Abnormal respiratory motile cilium physiology (HP:0012261)8.09623371
4Infertility (HP:0000789)7.54425308
5Chronic bronchitis (HP:0004469)6.57079768
6Rhinitis (HP:0012384)6.55052680
7Male infertility (HP:0003251)6.42215229
8Abnormal ciliary motility (HP:0012262)6.06479041
9Nasal polyposis (HP:0100582)6.03957172
10Severe visual impairment (HP:0001141)5.76015700
11Abnormality of the nasal mucosa (HP:0000433)4.97432652
12Attenuation of retinal blood vessels (HP:0007843)4.94399756
13Bony spicule pigmentary retinopathy (HP:0007737)4.42087235
14Chronic hepatic failure (HP:0100626)4.21099572
15Bronchiectasis (HP:0002110)4.14210961
16Bronchitis (HP:0012387)4.12073198
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.90682359
18Enlarged epiphyses (HP:0010580)3.89854364
19Abnormality of the costochondral junction (HP:0000919)3.84486291
20Cone-rod dystrophy (HP:0000548)3.82069189
21Gastrointestinal infarctions (HP:0005244)3.39455548
22Nephronophthisis (HP:0000090)3.36920013
23Recurrent otitis media (HP:0000403)3.27788622
24Hypoalphalipoproteinemia (HP:0003233)3.24493474
25Hyperkalemia (HP:0002153)3.24250787
26Abnormal spermatogenesis (HP:0008669)3.19771037
27Abnormality of the hepatic vasculature (HP:0006707)3.15974436
28Widely patent fontanelles and sutures (HP:0004492)3.07578336
29Hypophosphatemic rickets (HP:0004912)3.06135912
30Abnormality of dental color (HP:0011073)3.05193129
31Resting tremor (HP:0002322)2.98312274
32Thin bony cortex (HP:0002753)2.93108044
33Choroideremia (HP:0001139)2.91097719
34Progressive sensorineural hearing impairment (HP:0000408)2.89447220
35Impulsivity (HP:0100710)2.88551262
36Amelogenesis imperfecta (HP:0000705)2.83376203
37Recurrent sinusitis (HP:0011108)2.74888437
38Portal hypertension (HP:0001409)2.72175096
39Abnormality of macular pigmentation (HP:0008002)2.70296774
40Hypoplasia of the thymus (HP:0000778)2.70236089
41Abnormality of macrophages (HP:0004311)2.64727829
42Abnormality of lateral ventricle (HP:0030047)2.59806712
43Optic neuritis (HP:0100653)2.54986571
44Retrobulbar optic neuritis (HP:0100654)2.54986571
45Gingivitis (HP:0000230)2.54520497
46Generalized aminoaciduria (HP:0002909)2.52690693
47Postural instability (HP:0002172)2.52209006
48Recurrent bronchitis (HP:0002837)2.48735485
49Aplasia/Hypoplasia of the earlobes (HP:0009906)2.46685614
50Asymmetric septal hypertrophy (HP:0001670)2.43656188
51Abnormality of the renal medulla (HP:0100957)2.42176998
52Recurrent pneumonia (HP:0006532)2.39892494
53Orchitis (HP:0100796)2.38775812
54Abnormal urine output (HP:0012590)2.38393365
55Facial shape deformation (HP:0011334)2.37434309
56Potter facies (HP:0002009)2.37434309
57Cholecystitis (HP:0001082)2.36459104
58Abnormal gallbladder physiology (HP:0012438)2.36459104
59Short humerus (HP:0005792)2.35504865
60Heterotopia (HP:0002282)2.32681185
61Alopecia of scalp (HP:0002293)2.32064644
62Truncal obesity (HP:0001956)2.30987888
63Gonadotropin excess (HP:0000837)2.30644261
64Recurrent bacterial skin infections (HP:0005406)2.28485985
65Myositis (HP:0100614)2.27879046
66Hypertriglyceridemia (HP:0002155)2.27487900
67Menstrual irregularities (HP:0000858)2.27216765
68Colitis (HP:0002583)2.26958787
69Bell-shaped thorax (HP:0001591)2.23086654
70Abnormal rod and cone electroretinograms (HP:0008323)2.20132463
71Tubular atrophy (HP:0000092)2.19700482
72Spastic tetraparesis (HP:0001285)2.18291764
73Delayed epiphyseal ossification (HP:0002663)2.17469960
74Recurrent abscess formation (HP:0002722)2.13659977
75Abnormality of the fingertips (HP:0001211)2.11769797
76Mesangial abnormality (HP:0001966)2.11581324
77Eczematoid dermatitis (HP:0000976)2.10868140
78Fetal akinesia sequence (HP:0001989)2.08789841
79Aplasia/hypoplasia of the humerus (HP:0006507)2.08744647
80Obstructive lung disease (HP:0006536)2.08442270
81Chronic obstructive pulmonary disease (HP:0006510)2.08442270
82Bulbar palsy (HP:0001283)2.07384699
83Recurrent gram-negative bacterial infections (HP:0005420)2.06016155
84Flat capital femoral epiphysis (HP:0003370)2.03514572
85Malignant hyperthermia (HP:0002047)2.03365686
86Medial flaring of the eyebrow (HP:0010747)2.01258002
87Clumsiness (HP:0002312)2.01053073
88Tubulointerstitial nephritis (HP:0001970)2.00320395
89Absent/shortened dynein arms (HP:0200106)11.9030854
90Dynein arm defect of respiratory motile cilia (HP:0012255)11.9030854
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.5726163
92Polyuria (HP:0000103)1.99318573
93Renal Fanconi syndrome (HP:0001994)1.99142907
94Abnormal albumin level (HP:0012116)1.96155289
95Hypoalbuminemia (HP:0003073)1.96155289
96Tubulointerstitial abnormality (HP:0001969)1.94729203
97Hemorrhage of the eye (HP:0011885)1.92784362
98Rickets (HP:0002748)1.90783854
99Tongue fasciculations (HP:0001308)1.90712248
100Progressive hearing impairment (HP:0001730)1.89443891
101Dyschromatopsia (HP:0007641)1.89223770
102Exercise-induced myalgia (HP:0003738)1.88700461
103Facial hemangioma (HP:0000329)1.85104262
104Renovascular hypertension (HP:0100817)1.84416386
105Pustule (HP:0200039)1.83866517
106Joint hemorrhage (HP:0005261)1.81458467
107Azoospermia (HP:0000027)1.81167207
108Progressive cerebellar ataxia (HP:0002073)1.80749012
109Myocardial infarction (HP:0001658)1.80620227
110Easy fatigability (HP:0003388)1.79792694
111Hypolipoproteinemia (HP:0010981)1.79628544
112Macular degeneration (HP:0000608)1.79406093
113Concave nail (HP:0001598)1.78973342
114Molar tooth sign on MRI (HP:0002419)1.78586480
115Abnormality of midbrain morphology (HP:0002418)1.78586480
116Elevated erythrocyte sedimentation rate (HP:0003565)1.77761815
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77373602
118Autoimmune thrombocytopenia (HP:0001973)1.75883044
119Flattened epiphyses (HP:0003071)1.73775936
120Abnormality of potassium homeostasis (HP:0011042)1.73009744
121Tubulointerstitial fibrosis (HP:0005576)1.72935333
122Facial diplegia (HP:0001349)1.72899654
123Rectal fistula (HP:0100590)1.72697213
124Rectovaginal fistula (HP:0000143)1.72697213
125Arterial thrombosis (HP:0004420)1.72293855
126Fatigable weakness (HP:0003473)1.72125888
127Abnormality of the neuromuscular junction (HP:0003398)1.72125888
128Rib fusion (HP:0000902)1.71811301
129Muscle fibrillation (HP:0010546)1.70819903
130Insulin-resistant diabetes mellitus (HP:0000831)1.70586003
131Ulnar bowing (HP:0003031)1.70157057
132Photophobia (HP:0000613)1.70097609
133Inflammation of the large intestine (HP:0002037)1.69005086
134Abnormality of the lower motor neuron (HP:0002366)1.67871250
135Aplasia/Hypoplasia of the thymus (HP:0010515)1.67761086
136Increased IgM level (HP:0003496)1.67676472
137Protuberant abdomen (HP:0001538)1.67138996
138Postaxial foot polydactyly (HP:0001830)1.64033260
139Poikiloderma (HP:0001029)1.63051085
140Stage 5 chronic kidney disease (HP:0003774)1.62316548
141Annular pancreas (HP:0001734)1.61157881
142Decreased central vision (HP:0007663)1.60607527
143Turricephaly (HP:0000262)1.59321212
144Hypochromic microcytic anemia (HP:0004840)1.55954232
145Vaginal fistula (HP:0004320)1.55037760
146Type 2 muscle fiber atrophy (HP:0003554)1.49382788
147Median cleft lip (HP:0000161)1.47788885
148Squamous cell carcinoma (HP:0002860)1.47196168
149Intestinal fistula (HP:0100819)1.47130740
150Albinism (HP:0001022)1.46639786
151Abnormality of male internal genitalia (HP:0000022)1.44221669
152Myoglobinuria (HP:0002913)1.43854977
153Double outlet right ventricle (HP:0001719)1.43015736
154Congenital malformation of the right heart (HP:0011723)1.43015736
155Polydipsia (HP:0001959)1.39808996
156Abnormal drinking behavior (HP:0030082)1.39808996
157Growth hormone excess (HP:0000845)1.39190111
158EMG: neuropathic changes (HP:0003445)1.38502490
159Muscle fiber atrophy (HP:0100295)1.37220028
160Polymicrogyria (HP:0002126)1.35439723
161Hypercholesterolemia (HP:0003124)1.34887166
162Neurofibrillary tangles (HP:0002185)1.34267152
163Abnormality of renal excretion (HP:0011036)1.33488175
164Decreased electroretinogram (ERG) amplitude (HP:0000654)1.32562393
165Short ribs (HP:0000773)1.32355656
166Postaxial hand polydactyly (HP:0001162)1.32297001
167Loss of speech (HP:0002371)1.30578082
168Polycythemia (HP:0001901)1.30329822
169Intestinal atresia (HP:0011100)1.30316984
170Malnutrition (HP:0004395)1.28852799
171Hypoplasia of the capital femoral epiphysis (HP:0003090)1.28756887
172Aplasia/Hypoplasia of the lens (HP:0008063)1.28427810
173Abnormality of vision evoked potentials (HP:0000649)1.28313165
174Short femoral neck (HP:0100864)1.28060912
175Increased CSF protein (HP:0002922)1.26623632
176Coronal craniosynostosis (HP:0004440)1.24170353
177Hypotelorism (HP:0000601)1.22379765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK7.24837707
2PLK46.62053821
3TESK15.90041910
4PDK35.80876730
5PDK45.80876730
6PRKD34.63220663
7PDK23.72918551
8MAPK152.97734934
9BRD42.68113987
10BLK2.53676862
11DYRK1B2.52031547
12INSRR2.40489420
13DDR22.30721337
14TYRO32.14078442
15PINK12.03303446
16MAP3K61.94950652
17IRAK31.86376387
18MAP3K141.85762524
19STK381.84255238
20PLK21.82037808
21CDK121.70357276
22PTK2B1.67230942
23PIK3CG1.65736216
24MAP3K111.61264314
25TBK11.54300731
26MAP2K31.49883464
27SIK21.49832459
28GRK61.46639177
29FGR1.44208438
30WNK41.41970106
31NEK21.39875476
32IKBKB1.38660241
33TNK21.37900920
34CSK1.37241415
35MATK1.36788704
36IKBKE1.30272387
37NEK61.29378413
38MAP4K21.28505098
39ERN11.27920767
40JAK31.27629358
41STK391.23149711
42ZAP701.16517472
43CAMK1D1.12477641
44BMX1.11101521
45DYRK31.10242373
46YES11.06392032
47KSR21.01398946
48IRAK41.01357043
49MST1R0.98172341
50DAPK10.98044324
51MAP3K130.95030644
52PRKD20.94045074
53TXK0.92304943
54PDK10.89207458
55UHMK10.87930746
56PIM20.87735538
57PIM10.86506399
58KIT0.86066984
59MAP3K10.82961925
60MAP3K100.81809475
61RIPK40.78423318
62CHUK0.78301002
63CHEK20.76295889
64RPS6KA20.74842778
65CDK60.74296842
66TLK10.72717053
67TESK20.72662334
68CDK40.71351088
69PNCK0.71135161
70MAP2K20.70633986
71TYK20.69480631
72SYK0.66968073
73PRPF4B0.65557090
74PDGFRA0.65410062
75STK30.63344490
76TAOK20.61535539
77PDPK10.61402536
78TRPM70.54713198
79PRKAA10.52666711
80MTOR0.51965010
81TAOK30.51073532
82MAP2K40.50847007
83GSK3A0.49005048
84CDK70.48944980
85AKT30.47543154
86RPS6KC10.47539401
87RPS6KL10.47539401
88RPS6KA10.46920008
89JAK20.46215648
90GRK70.44592791
91PAK10.42614191
92RPS6KA60.42377872
93BRAF0.42277706
94ACVR1B0.42127339
95MAP3K30.40779333
96BMPR20.39404524
97BTK0.37342546
98CSF1R0.35228057
99PRKCZ0.34645907
100RPS6KB10.34103633
101IRAK10.34047689
102HCK0.33892304
103NTRK20.33219446
104MAPK80.32834145
105LCK0.32684100
106LATS20.32483462
107PRKG10.30858380
108CDC42BPA0.30746039
109TRIB30.30699877
110WNK10.30652360
111PAK40.30495252
112EGFR0.29120015
113MARK20.28724089
114PLK10.28359680
115ATR0.27774450
116JAK10.27555955
117PHKG10.27237756
118PHKG20.27237756
119SIK10.26641134
120PAK20.26503319
121DAPK20.25691389
122MAPK110.25464636
123CHEK10.25253360
124EEF2K0.24573012
125MAP3K80.24255181
126STK100.23748991
127TTK0.23584722
128MAP2K60.23301103
129EPHB10.22301909
130ATM0.21097481
131CSNK2A10.20442720
132STK38L0.18912180
133IRAK20.17744006
134PDGFRB0.17235392
135MAPK40.16457428
136MUSK0.16329954
137PRKG20.16144560
138PRKCD0.15804873
139CAMK1G0.15773453
140CDK20.13567647
141PRKAA20.12938713
142TAOK10.11627705
143CDK150.11543998
144MAPK10.09817207
145PRKACG0.09672709
146PRKCG0.09461299
147CAMK2A0.09447138
148CCNB10.09024572
149CDK11A0.09014328
150CDK180.08111732
151PTK20.07924577
152LYN0.07848694
153GSK3B0.07260085
154INSR0.06111525
155MAP4K10.05660346
156CSNK2A20.05026180

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.55815192
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.39661396
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.69473564
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.62011116
5Linoleic acid metabolism_Homo sapiens_hsa005912.51656420
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51134581
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.38716743
8Pyruvate metabolism_Homo sapiens_hsa006202.30547164
9Fatty acid metabolism_Homo sapiens_hsa012122.19092684
10Fructose and mannose metabolism_Homo sapiens_hsa000512.11187356
11Osteoclast differentiation_Homo sapiens_hsa043802.09525027
12Leishmaniasis_Homo sapiens_hsa051402.09472913
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.07642663
14Allograft rejection_Homo sapiens_hsa053302.02853993
15Glucagon signaling pathway_Homo sapiens_hsa049221.98007569
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.96812560
17Vitamin B6 metabolism_Homo sapiens_hsa007501.93258597
18Base excision repair_Homo sapiens_hsa034101.90980187
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87861966
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.86724919
21Graft-versus-host disease_Homo sapiens_hsa053321.85418640
22Influenza A_Homo sapiens_hsa051641.85315926
23Glycerolipid metabolism_Homo sapiens_hsa005611.78650742
24Hedgehog signaling pathway_Homo sapiens_hsa043401.77802226
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.73311058
26Dorso-ventral axis formation_Homo sapiens_hsa043201.70211574
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.67755486
28Autoimmune thyroid disease_Homo sapiens_hsa053201.67626265
29Olfactory transduction_Homo sapiens_hsa047401.64006906
30Selenocompound metabolism_Homo sapiens_hsa004501.61778746
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.60771472
32Mineral absorption_Homo sapiens_hsa049781.60314595
33Propanoate metabolism_Homo sapiens_hsa006401.58865524
34Type I diabetes mellitus_Homo sapiens_hsa049401.58241509
35PPAR signaling pathway_Homo sapiens_hsa033201.54650098
36Other glycan degradation_Homo sapiens_hsa005111.52679970
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.48599584
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48208419
39Fat digestion and absorption_Homo sapiens_hsa049751.44070256
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.43891961
41mRNA surveillance pathway_Homo sapiens_hsa030151.43878056
42Oocyte meiosis_Homo sapiens_hsa041141.43271157
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.42805678
44Biosynthesis of amino acids_Homo sapiens_hsa012301.39968459
45Tuberculosis_Homo sapiens_hsa051521.38499646
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.38000505
47Basal transcription factors_Homo sapiens_hsa030221.35181754
48Fanconi anemia pathway_Homo sapiens_hsa034601.34502614
49TNF signaling pathway_Homo sapiens_hsa046681.32454340
50Mismatch repair_Homo sapiens_hsa034301.32147727
51Legionellosis_Homo sapiens_hsa051341.29271917
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.28739681
53Glutathione metabolism_Homo sapiens_hsa004801.25633243
54Malaria_Homo sapiens_hsa051441.23456835
55Type II diabetes mellitus_Homo sapiens_hsa049301.21941011
56Toxoplasmosis_Homo sapiens_hsa051451.21251470
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19422618
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16686167
59DNA replication_Homo sapiens_hsa030301.12552632
60Herpes simplex infection_Homo sapiens_hsa051681.11038721
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10658949
62Chemokine signaling pathway_Homo sapiens_hsa040621.10194072
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09626467
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06945324
65Asthma_Homo sapiens_hsa053101.05051233
66Pertussis_Homo sapiens_hsa051331.04423417
67Fatty acid degradation_Homo sapiens_hsa000711.04362486
68Pentose phosphate pathway_Homo sapiens_hsa000301.04115678
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01756103
70RNA transport_Homo sapiens_hsa030130.98943951
71VEGF signaling pathway_Homo sapiens_hsa043700.98893981
72Inositol phosphate metabolism_Homo sapiens_hsa005620.96249510
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95333536
74African trypanosomiasis_Homo sapiens_hsa051430.94169103
75Lysosome_Homo sapiens_hsa041420.94122834
76Carbon metabolism_Homo sapiens_hsa012000.93749942
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89459175
78mTOR signaling pathway_Homo sapiens_hsa041500.89150713
79Viral myocarditis_Homo sapiens_hsa054160.85576399
80Arginine and proline metabolism_Homo sapiens_hsa003300.85287405
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83984083
82Amphetamine addiction_Homo sapiens_hsa050310.83088007
83Prolactin signaling pathway_Homo sapiens_hsa049170.83078023
84Taste transduction_Homo sapiens_hsa047420.82038543
85Ether lipid metabolism_Homo sapiens_hsa005650.81794270
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81689324
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81505500
88Sphingolipid metabolism_Homo sapiens_hsa006000.80348922
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79876374
90Shigellosis_Homo sapiens_hsa051310.78348149
91Hematopoietic cell lineage_Homo sapiens_hsa046400.78133634
92T cell receptor signaling pathway_Homo sapiens_hsa046600.78103320
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76963469
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76216652
95Estrogen signaling pathway_Homo sapiens_hsa049150.73691321
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.73044685
97Rheumatoid arthritis_Homo sapiens_hsa053230.71062932
98AMPK signaling pathway_Homo sapiens_hsa041520.70601163
99Primary immunodeficiency_Homo sapiens_hsa053400.68552805
100Phenylalanine metabolism_Homo sapiens_hsa003600.68251615
101Hepatitis B_Homo sapiens_hsa051610.67147796
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.66675306
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.66659113
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.66306009
105Insulin resistance_Homo sapiens_hsa049310.66094575
106Arachidonic acid metabolism_Homo sapiens_hsa005900.65301428
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63710875
108Cardiac muscle contraction_Homo sapiens_hsa042600.63001382
109Sulfur relay system_Homo sapiens_hsa041220.62192698
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61206294
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59887198
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58068796
113Hepatitis C_Homo sapiens_hsa051600.57693221
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57088204
115ABC transporters_Homo sapiens_hsa020100.56840074
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56729477
117Endocytosis_Homo sapiens_hsa041440.56359676
118Adherens junction_Homo sapiens_hsa045200.56108790
119Circadian rhythm_Homo sapiens_hsa047100.54356134
120MAPK signaling pathway_Homo sapiens_hsa040100.54123653
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53609574
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.53598500
123Antigen processing and presentation_Homo sapiens_hsa046120.51737864
124Notch signaling pathway_Homo sapiens_hsa043300.50717420
125Non-small cell lung cancer_Homo sapiens_hsa052230.49889448
126Chemical carcinogenesis_Homo sapiens_hsa052040.48877199
127Wnt signaling pathway_Homo sapiens_hsa043100.48350648
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48180915
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46500317
130Basal cell carcinoma_Homo sapiens_hsa052170.46498543
131Epstein-Barr virus infection_Homo sapiens_hsa051690.45986879
132Hippo signaling pathway_Homo sapiens_hsa043900.43334551
133Bile secretion_Homo sapiens_hsa049760.42939888
134Salmonella infection_Homo sapiens_hsa051320.41145830
135B cell receptor signaling pathway_Homo sapiens_hsa046620.40382091
136Renin secretion_Homo sapiens_hsa049240.39527860
137Calcium signaling pathway_Homo sapiens_hsa040200.39504995
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38993587
139Platelet activation_Homo sapiens_hsa046110.38732668
140Collecting duct acid secretion_Homo sapiens_hsa049660.38366275
141cAMP signaling pathway_Homo sapiens_hsa040240.35250195
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33232985
143Prion diseases_Homo sapiens_hsa050200.32312284
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32019735
145Thyroid hormone synthesis_Homo sapiens_hsa049180.31187290
146Staphylococcus aureus infection_Homo sapiens_hsa051500.26207373
147Insulin signaling pathway_Homo sapiens_hsa049100.26099261
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23264549
149HIF-1 signaling pathway_Homo sapiens_hsa040660.22994900
150Systemic lupus erythematosus_Homo sapiens_hsa053220.21050660
151Viral carcinogenesis_Homo sapiens_hsa052030.20916977
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19660531
153Purine metabolism_Homo sapiens_hsa002300.19160024
154Arginine biosynthesis_Homo sapiens_hsa002200.18704129
155Bladder cancer_Homo sapiens_hsa052190.18438127
156Acute myeloid leukemia_Homo sapiens_hsa052210.18418831
157Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18367851
158Measles_Homo sapiens_hsa051620.18268731
159Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17069912
160Metabolic pathways_Homo sapiens_hsa011000.16614828
161Galactose metabolism_Homo sapiens_hsa000520.15793735
162Renin-angiotensin system_Homo sapiens_hsa046140.15521282
163Nucleotide excision repair_Homo sapiens_hsa034200.13859808

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »