SPATC1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.64411309
2cell-cell recognition (GO:0009988)9.37174791
3multicellular organism reproduction (GO:0032504)9.26942918
4spermatid development (GO:0007286)9.00208616
5axonemal dynein complex assembly (GO:0070286)8.75284806
6epithelial cilium movement (GO:0003351)8.72551165
7plasma membrane fusion (GO:0045026)8.68837884
8motile cilium assembly (GO:0044458)8.67155728
9reproduction (GO:0000003)8.12005718
10regulation of cilium movement (GO:0003352)7.87482839
11cilium or flagellum-dependent cell motility (GO:0001539)7.53689898
12organic cation transport (GO:0015695)7.10156551
13cilium movement (GO:0003341)6.98660604
14negative regulation of inclusion body assembly (GO:0090084)6.69142693
15sperm capacitation (GO:0048240)6.63231862
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.51690835
17single fertilization (GO:0007338)6.41997952
18synaptonemal complex organization (GO:0070193)6.39779512
19piRNA metabolic process (GO:0034587)6.33591716
20spermatogenesis (GO:0007283)6.26665105
21male gamete generation (GO:0048232)6.24208694
22synaptonemal complex assembly (GO:0007130)6.23678335
23male meiosis (GO:0007140)6.17370774
24gamete generation (GO:0007276)5.71300901
25regulation of inclusion body assembly (GO:0090083)5.70053384
26fertilization (GO:0009566)5.58520858
27microtubule depolymerization (GO:0007019)5.58103581
28calcium ion-dependent exocytosis (GO:0017156)5.12031060
29chromosome condensation (GO:0030261)4.97007947
30germ cell development (GO:0007281)4.90806401
31cellular process involved in reproduction in multicellular organism (GO:0022412)4.83442665
32glycerol ether metabolic process (GO:0006662)4.82146559
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.79773286
34DNA packaging (GO:0006323)4.70319060
35peptidyl-arginine omega-N-methylation (GO:0035247)4.60466786
36regulation of microtubule-based movement (GO:0060632)4.58030110
37multicellular organismal reproductive process (GO:0048609)4.50769578
38ether metabolic process (GO:0018904)4.44454923
39seminiferous tubule development (GO:0072520)4.41549507
40male meiosis I (GO:0007141)4.41381068
41cell recognition (GO:0008037)4.40260139
42ventricular system development (GO:0021591)4.32755705
43microtubule severing (GO:0051013)4.23319189
44chaperone-mediated protein complex assembly (GO:0051131)4.21213897
45chromosome organization involved in meiosis (GO:0070192)4.14677009
46spermatid nucleus differentiation (GO:0007289)4.14603825
47sexual reproduction (GO:0019953)4.09725519
48protein maturation by protein folding (GO:0022417)4.06309875
49peptidyl-arginine methylation (GO:0018216)4.03254764
50peptidyl-arginine N-methylation (GO:0035246)4.03254764
51DNA methylation involved in gamete generation (GO:0043046)3.99340458
52histone arginine methylation (GO:0034969)3.95640751
53left/right pattern formation (GO:0060972)3.93341651
54oxidative phosphorylation (GO:0006119)3.92833012
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.90839523
56protein retention in ER lumen (GO:0006621)3.90692004
57nucleosome disassembly (GO:0006337)3.90140331
58protein-DNA complex disassembly (GO:0032986)3.90140331
59regulation of mitochondrial translation (GO:0070129)3.84675609
60DNA unwinding involved in DNA replication (GO:0006268)3.72202309
61fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.71267425
62carnitine transport (GO:0015879)3.70771362
63amino-acid betaine transport (GO:0015838)3.70771362
64establishment of integrated proviral latency (GO:0075713)3.70487866
65formation of translation preinitiation complex (GO:0001731)3.68624150
66maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.65186517
67COPI coating of Golgi vesicle (GO:0048205)3.62682338
68Golgi transport vesicle coating (GO:0048200)3.62682338
69proline biosynthetic process (GO:0006561)3.62180571
70pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.59092626
71meiotic nuclear division (GO:0007126)3.58876041
72multicellular organismal development (GO:0007275)3.56962153
73chaperone-mediated protein transport (GO:0072321)3.55138441
74mitotic nuclear envelope reassembly (GO:0007084)3.53792419
75nuclear envelope reassembly (GO:0031468)3.53792419
76establishment of viral latency (GO:0019043)3.52187295
77carnitine transmembrane transport (GO:1902603)3.49578107
78meiosis I (GO:0007127)3.47601739
79genitalia morphogenesis (GO:0035112)3.39735540
80DNA strand elongation involved in DNA replication (GO:0006271)3.38440906
81L-serine metabolic process (GO:0006563)3.37225982
82single strand break repair (GO:0000012)3.35638191
83rRNA modification (GO:0000154)3.33438856
84peptidyl-glutamic acid modification (GO:0018200)3.30680896
85tRNA aminoacylation for protein translation (GO:0006418)3.30421399
86regulation of translational fidelity (GO:0006450)3.30033840
87DNA strand elongation (GO:0022616)3.28063655
88iron-sulfur cluster assembly (GO:0016226)3.27422189
89metallo-sulfur cluster assembly (GO:0031163)3.27422189
90pyrimidine nucleotide catabolic process (GO:0006244)3.26116159
91negative regulation of DNA-templated transcription, elongation (GO:0032785)3.25956091
922-deoxyribonucleotide biosynthetic process (GO:0009265)3.21961643
93deoxyribose phosphate biosynthetic process (GO:0046385)3.21961643
94urea metabolic process (GO:0019627)3.21209193
95urea cycle (GO:0000050)3.21209193
96tRNA aminoacylation (GO:0043039)3.17394657
97amino acid activation (GO:0043038)3.17394657
98proteasome assembly (GO:0043248)3.16860392
99protein targeting to mitochondrion (GO:0006626)3.16725097
100ATP synthesis coupled proton transport (GO:0015986)3.15921564
101energy coupled proton transport, down electrochemical gradient (GO:0015985)3.15921564
102negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.15098781
103protoporphyrinogen IX metabolic process (GO:0046501)3.14915581
104alditol metabolic process (GO:0019400)3.13727267
105negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.12646083
106mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09863963
107erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.09850729
108L-phenylalanine catabolic process (GO:0006559)3.09850729
109ribosome biogenesis (GO:0042254)3.09295668
110pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.07643739
111fructose metabolic process (GO:0006000)3.05130940
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.03837190
113protein polyglutamylation (GO:0018095)3.03804939
114DNA replication initiation (GO:0006270)3.03735661
115sequestering of actin monomers (GO:0042989)3.03367599
116positive regulation of glycolytic process (GO:0045821)3.01062987
117telomere maintenance via semi-conservative replication (GO:0032201)3.00560030
118pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.98728460
119guanosine-containing compound biosynthetic process (GO:1901070)2.98588383
120protoporphyrinogen IX biosynthetic process (GO:0006782)2.98331703
121protein insertion into membrane (GO:0051205)2.98087415
122ribosomal small subunit biogenesis (GO:0042274)2.94398121
123nitrogen cycle metabolic process (GO:0071941)2.93149535
124establishment of protein localization to mitochondrion (GO:0072655)2.92534133
125glycolytic process (GO:0006096)2.92421593
126alpha-linolenic acid metabolic process (GO:0036109)2.92251700
127meiotic cell cycle (GO:0051321)2.89222433
128protein K11-linked deubiquitination (GO:0035871)2.88499796
129GDP-mannose metabolic process (GO:0019673)2.87627724
130negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87430126
131negative regulation of ligase activity (GO:0051352)2.87430126
132pentose metabolic process (GO:0019321)2.87190097
133mitochondrial respiratory chain complex I assembly (GO:0032981)2.87174274
134NADH dehydrogenase complex assembly (GO:0010257)2.87174274
135mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87174274
136heme biosynthetic process (GO:0006783)2.87144929
137ribonucleoprotein complex biogenesis (GO:0022613)2.86848628
138retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86288696
139protein refolding (GO:0042026)2.86278005
140ribosomal small subunit assembly (GO:0000028)2.85217345
141L-phenylalanine metabolic process (GO:0006558)2.83847017
142erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.83847017
143regulation of spindle checkpoint (GO:0090231)2.83292492
144pseudouridine synthesis (GO:0001522)2.83282880
145quaternary ammonium group transport (GO:0015697)2.83255590
146polyamine biosynthetic process (GO:0006596)2.82470184
147amino-acid betaine metabolic process (GO:0006577)2.82396651
148protein localization to mitochondrion (GO:0070585)2.81178657
149rRNA methylation (GO:0031167)2.81051292
150establishment of mitochondrion localization (GO:0051654)2.80533029
151positive regulation of macrophage activation (GO:0043032)2.79982894
152polyol catabolic process (GO:0046174)2.77730906
153RNA localization (GO:0006403)2.76872398
154cellular component biogenesis (GO:0044085)2.75930621
155DNA replication checkpoint (GO:0000076)2.75174978
156regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.74519079
157interferon-gamma secretion (GO:0072643)2.74196193
158inner mitochondrial membrane organization (GO:0007007)2.73629536
159base-excision repair, AP site formation (GO:0006285)2.73576850
160protein localization to cilium (GO:0061512)2.72873622
161protein complex biogenesis (GO:0070271)2.72845473
162base-excision repair (GO:0006284)2.72749619
163microtubule polymerization or depolymerization (GO:0031109)2.71247446
164pentose-phosphate shunt (GO:0006098)2.69475948
165DNA damage response, detection of DNA damage (GO:0042769)2.68548125
166GMP metabolic process (GO:0046037)2.68404932
167mitochondrial respiratory chain complex assembly (GO:0033108)2.68215127
168aromatic amino acid family catabolic process (GO:0009074)2.67308873
169positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67106511
170anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.66795379
171positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.64099267
172porphyrin-containing compound biosynthetic process (GO:0006779)2.63606424
173carnitine metabolic process (GO:0009437)2.63297725
174establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62173789
175mitochondrion transport along microtubule (GO:0047497)2.62173789
176nucleus organization (GO:0006997)2.60739612
177viral mRNA export from host cell nucleus (GO:0046784)2.60502732
178UTP biosynthetic process (GO:0006228)2.59724619
179mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.58620450
180glycerol metabolic process (GO:0006071)2.58265376
181spliceosomal snRNP assembly (GO:0000387)2.57948678
182peptidyl-histidine modification (GO:0018202)2.57850846
183IMP biosynthetic process (GO:0006188)2.57284715
184RNA destabilization (GO:0050779)2.57113672
185transcription from mitochondrial promoter (GO:0006390)2.56874510
186lactate metabolic process (GO:0006089)2.56129584
187regulation of translational elongation (GO:0006448)2.55615726
188NADPH regeneration (GO:0006740)2.55524049
189de novo protein folding (GO:0006458)2.55392608
190nucleoside diphosphate phosphorylation (GO:0006165)2.54073699
191mitotic sister chromatid cohesion (GO:0007064)2.51644767
192monoubiquitinated protein deubiquitination (GO:0035520)2.49706410
193sperm motility (GO:0030317)13.1521089
194acrosome reaction (GO:0007340)11.5454042
195fusion of sperm to egg plasma membrane (GO:0007342)11.4874556
196cell wall macromolecule catabolic process (GO:0016998)11.4292684
197cell wall macromolecule metabolic process (GO:0044036)11.4292684
198sperm-egg recognition (GO:0035036)10.4654716
199acrosome assembly (GO:0001675)10.1570681

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.46313260
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81978740
3E2F7_22180533_ChIP-Seq_HELA_Human3.55607565
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.52333546
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.42551720
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.38967222
7EZH2_22144423_ChIP-Seq_EOC_Human3.37444161
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.31612651
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16906529
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.00955933
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.98225134
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90363638
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88562222
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.66176960
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.62084512
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.59991793
17XRN2_22483619_ChIP-Seq_HELA_Human2.58305198
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.47266989
19CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.43970893
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39157682
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38592268
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31849892
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25391112
24VDR_22108803_ChIP-Seq_LS180_Human2.23157548
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.17759314
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17070130
27GABP_19822575_ChIP-Seq_HepG2_Human2.14275522
28RXR_22158963_ChIP-Seq_LIVER_Mouse2.13411979
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13117139
30LXR_22158963_ChIP-Seq_LIVER_Mouse2.12697879
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06593708
32EGR1_23403033_ChIP-Seq_LIVER_Mouse2.02657446
33PPARA_22158963_ChIP-Seq_LIVER_Mouse2.02382691
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.02137195
35YY1_21170310_ChIP-Seq_MESCs_Mouse2.00941391
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00257914
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98935620
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98426113
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.94367105
40CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.92663286
41DCP1A_22483619_ChIP-Seq_HELA_Human1.88113121
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.87673411
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.85172047
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85080786
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82713535
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82097399
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80811351
48FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78618513
49STAT1_17558387_ChIP-Seq_HELA_Human1.77294884
50TTF2_22483619_ChIP-Seq_HELA_Human1.77153213
51ZNF274_21170338_ChIP-Seq_K562_Hela1.71899188
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71172202
53SOX2_22085726_ChIP-Seq_NPCs_Mouse1.67378432
54ELK4_26923725_Chip-Seq_MESODERM_Mouse1.66582864
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64726294
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.62170115
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.60997554
58FOXP3_21729870_ChIP-Seq_TREG_Human1.60484788
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.58600639
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.58167288
61CIITA_25753668_ChIP-Seq_RAJI_Human1.56302400
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55547985
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54978886
64GATA3_21867929_ChIP-Seq_CD8_Mouse1.54732055
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.53021924
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.52955988
67TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.52754571
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51767925
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.50393963
70ZNF263_19887448_ChIP-Seq_K562_Human1.50302906
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.49262824
72KDM5A_27292631_Chip-Seq_BREAST_Human1.49160305
73P53_21459846_ChIP-Seq_SAOS-2_Human1.48976317
74RXRA_24833708_ChIP-Seq_LIVER_Mouse1.48533130
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47408648
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47331631
77FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47253940
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.45738418
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45491486
80GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.43829184
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43817981
82LXR_22292898_ChIP-Seq_THP-1_Human1.41816361
83MYC_22102868_ChIP-Seq_BL_Human1.41122836
84NCOR1_26117541_ChIP-Seq_K562_Human1.40764791
85E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40746646
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40390522
87VDR_21846776_ChIP-Seq_THP-1_Human1.40327115
88RAD21_21589869_ChIP-Seq_MESCs_Mouse1.39678487
89WDR5_24793694_ChIP-Seq_LNCAP_Human1.38990874
90KAP1_22055183_ChIP-Seq_ESCs_Mouse1.38384805
91P68_20966046_ChIP-Seq_HELA_Human1.38111507
92FOXP1_21924763_ChIP-Seq_HESCs_Human1.37302038
93LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.37088740
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36530293
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36364132
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35743733
97VDR_23849224_ChIP-Seq_CD4+_Human1.34056550
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33919615
99CBP_20019798_ChIP-Seq_JUKART_Human1.33919615
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33228676
101SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32791242
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31417721
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30969032
104KDM2B_26808549_Chip-Seq_REH_Human1.30647608
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30388155
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29530528
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28157864
108PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27073687
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27031354
110TAL1_26923725_Chip-Seq_HPCs_Mouse1.26638805
111CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26244662
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24351837
113ELK3_25401928_ChIP-Seq_HUVEC_Human1.23076223
114SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22276937
115SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21288361
116PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21122703
117RARA_24833708_ChIP-Seq_LIVER_Mouse1.20872540
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19615135
119SPI1_26923725_Chip-Seq_HPCs_Mouse1.19318294
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19125183
121CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18962381
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18769299
123MYC_27129775_Chip-Seq_CORNEA_Mouse1.17591555
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17520324
125GATA3_21867929_ChIP-Seq_TH1_Mouse1.17109983
126ERG_20517297_ChIP-Seq_VCAP_Human1.16287864
127GF1_26923725_Chip-Seq_HPCs_Mouse1.16149108
128MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15918530
129TET1_21451524_ChIP-Seq_MESCs_Mouse1.15624864
130SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14773746
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13677045
132ESET_19884257_ChIP-Seq_ESCs_Mouse1.13468219
133NFE2_27457419_Chip-Seq_LIVER_Mouse1.12105020
134HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11001192
135REST_21632747_ChIP-Seq_MESCs_Mouse1.10321065
136SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10311399
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.09608124
138FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09200904
139CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08637875
140CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08339027
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08272608
142CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07583523
143BCL6_27268052_Chip-Seq_Bcells_Human1.07516005
144CTCF_20526341_ChIP-Seq_ESCs_Human1.06973182
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06693285
146JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05988067
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04765487
148RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04734494
149SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04263258
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03035796
151SA1_27219007_Chip-Seq_ERYTHROID_Human1.02998156
152NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02810236
153PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02634286
154POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02237881
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01905164
156TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01411708
157CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00598842
158POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00500027
159SOX11_22085726_ChIP-Seq_ESNs_Mouse1.00428962
160CRX_20693478_ChIP-Seq_RETINA_Mouse1.00234359
161TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00174268
162POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00174268
163PHF8_20622854_ChIP-Seq_HELA_Human0.98885581
164SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98828893
165GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98702264
166GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98659924
167TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98628748
168CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98435098
169BCOR_27268052_Chip-Seq_Bcells_Human0.98063738
170E2F1_21310950_ChIP-Seq_MCF-7_Human0.97882183
171SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96526262
172ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96477483
173LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96000876
174SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95867888
175YY1_22570637_ChIP-Seq_MALME-3M_Human0.95662649
176SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95640995
177ELF1_20517297_ChIP-Seq_JURKAT_Human0.94277353
178E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93442295
179EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93390620
180RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93313650
181CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93279107
182FLI1_21867929_ChIP-Seq_CD8_Mouse0.92299202
183SOX2_21211035_ChIP-Seq_LN229_Human0.92185415
184PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91458161
185NANOG_20526341_ChIP-Seq_ESCs_Human0.91274606
186TAF15_26573619_Chip-Seq_HEK293_Human0.90991245
187CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90098338
188TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89490745
189NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88571772
190SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87976622
191CTCF_27219007_Chip-Seq_Bcells_Human0.86862177
192NFYB_21822215_ChIP-Seq_K562_Human0.86515756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.18067706
2MP0001929_abnormal_gametogenesis4.74088637
3MP0002139_abnormal_hepatobiliary_system4.31047299
4MP0003693_abnormal_embryo_hatching3.74756643
5MP0005360_urolithiasis3.61598264
6MP0005670_abnormal_white_adipose3.13858580
7MP0005365_abnormal_bile_salt3.02900577
8MP0003111_abnormal_nucleus_morphology2.94297034
9MP0005085_abnormal_gallbladder_physiolo2.88002848
10MP0002161_abnormal_fertility/fecundity2.86705279
11MP0001529_abnormal_vocalization2.84127321
12MP0008877_abnormal_DNA_methylation2.82631075
13MP0003123_paternal_imprinting2.78721528
14MP0008932_abnormal_embryonic_tissue2.75752730
15MP0004957_abnormal_blastocyst_morpholog2.73497820
16MP0002210_abnormal_sex_determination2.72347091
17MP0004147_increased_porphyrin_level2.67695928
18MP0000678_abnormal_parathyroid_gland2.43042502
19MP0008875_abnormal_xenobiotic_pharmacok2.40978993
20MP0008058_abnormal_DNA_repair2.40932767
21MP0006292_abnormal_olfactory_placode2.36037415
22MP0001145_abnormal_male_reproductive2.33706290
23MP0010094_abnormal_chromosome_stability2.17776983
24MP0003806_abnormal_nucleotide_metabolis2.13989559
25MP0003077_abnormal_cell_cycle2.11370483
26MP0000653_abnormal_sex_gland2.04410856
27MP0005410_abnormal_fertilization14.7171936
28MP0005499_abnormal_olfactory_system1.99840918
29MP0005394_taste/olfaction_phenotype1.99840918
30MP0008789_abnormal_olfactory_epithelium1.98532605
31MP0008007_abnormal_cellular_replicative1.96392922
32MP0001730_embryonic_growth_arrest1.90076475
33MP0004859_abnormal_synaptic_plasticity1.87792836
34MP0003252_abnormal_bile_duct1.86068602
35MP0010329_abnormal_lipoprotein_level1.70150117
36MP0001188_hyperpigmentation1.68809825
37MP0002249_abnormal_larynx_morphology1.56757985
38MP0002653_abnormal_ependyma_morphology1.56683297
39MP0004858_abnormal_nervous_system1.56661338
40MP0006276_abnormal_autonomic_nervous1.52889078
41MP0002132_abnormal_respiratory_system1.51100868
42MP0003786_premature_aging1.50659138
43MP0003121_genomic_imprinting1.49046534
44MP0009278_abnormal_bone_marrow1.46987797
45MP0003718_maternal_effect1.45018205
46MP0003646_muscle_fatigue1.44215288
47MP0004145_abnormal_muscle_electrophysio1.43872841
48MP0003011_delayed_dark_adaptation1.43553583
49MP0001727_abnormal_embryo_implantation1.42836624
50MP0000049_abnormal_middle_ear1.42148149
51MP0002080_prenatal_lethality1.36682334
52MP0002160_abnormal_reproductive_system1.32859325
53MP0002163_abnormal_gland_morphology1.32365820
54MP0003122_maternal_imprinting1.25250639
55MP0000313_abnormal_cell_death1.25231359
56MP0004019_abnormal_vitamin_homeostasis1.24414087
57MP0005332_abnormal_amino_acid1.23804966
58MP0001764_abnormal_homeostasis1.22187649
59MP0005647_abnormal_sex_gland1.21686435
60MP0003385_abnormal_body_wall1.21200642
61MP0002282_abnormal_trachea_morphology1.20027805
62MP0000350_abnormal_cell_proliferation1.19579960
63MP0000372_irregular_coat_pigmentation1.15278498
64MP0004133_heterotaxia1.14406119
65MP0001697_abnormal_embryo_size1.14356730
66MP0005083_abnormal_biliary_tract1.11890439
67MP0001672_abnormal_embryogenesis/_devel1.10958767
68MP0005380_embryogenesis_phenotype1.10958767
69MP0000751_myopathy1.10500022
70MP0002085_abnormal_embryonic_tissue1.09768257
71MP0003195_calcinosis1.09227776
72MP0001765_abnormal_ion_homeostasis1.08297692
73MP0002118_abnormal_lipid_homeostasis1.07911406
74MP0001905_abnormal_dopamine_level1.06881733
75MP0004233_abnormal_muscle_weight1.02950186
76MP0003221_abnormal_cardiomyocyte_apopto1.02339761
77MP0010030_abnormal_orbit_morphology1.02230891
78MP0005636_abnormal_mineral_homeostasis1.02062303
79MP0005645_abnormal_hypothalamus_physiol0.98630555
80MP0000955_abnormal_spinal_cord0.98528834
81MP0005319_abnormal_enzyme/_coenzyme0.97650067
82MP0000609_abnormal_liver_physiology0.96455959
83MP0003787_abnormal_imprinting0.95388820
84MP0000681_abnormal_thyroid_gland0.92684487
85MP0003861_abnormal_nervous_system0.90660479
86MP0003984_embryonic_growth_retardation0.90225054
87MP0002084_abnormal_developmental_patter0.89945455
88MP0005058_abnormal_lysosome_morphology0.89619588
89MP0004811_abnormal_neuron_physiology0.89455460
90MP0001984_abnormal_olfaction0.87925571
91MP0003329_amyloid_beta_deposits0.85481848
92MP0009840_abnormal_foam_cell0.85316550
93MP0002751_abnormal_autonomic_nervous0.81091528
94MP0001666_abnormal_nutrient_absorption0.80891979
95MP0002088_abnormal_embryonic_growth/wei0.80646899
96MP0006036_abnormal_mitochondrial_physio0.78036808
97MP0003880_abnormal_central_pattern0.77244229
98MP0005379_endocrine/exocrine_gland_phen0.76537111
99MP0000750_abnormal_muscle_regeneration0.76454266
100MP0005584_abnormal_enzyme/coenzyme_acti0.76217372
101MP0009697_abnormal_copulation0.76089480
102MP0005666_abnormal_adipose_tissue0.75521084
103MP0003119_abnormal_digestive_system0.74944524
104MP0000604_amyloidosis0.74933962
105MP0005501_abnormal_skin_physiology0.74002688
106MP0004197_abnormal_fetal_growth/weight/0.73620402
107MP0003868_abnormal_feces_composition0.72635153
108MP0005384_cellular_phenotype0.72223250
109MP0002752_abnormal_somatic_nervous0.71686884
110MP0008770_decreased_survivor_rate0.71637761
111MP0002184_abnormal_innervation0.71324621
112MP0002138_abnormal_hepatobiliary_system0.69379385
113MP0004185_abnormal_adipocyte_glucose0.69101179
114MP0008260_abnormal_autophagy0.67371360
115MP0005623_abnormal_meninges_morphology0.64296464
116MP0000778_abnormal_nervous_system0.63801001
117MP0003191_abnormal_cellular_cholesterol0.63562498
118MP0005389_reproductive_system_phenotype0.62867583
119MP0003115_abnormal_respiratory_system0.60510421
120MP0002234_abnormal_pharynx_morphology0.60311897
121MP0005451_abnormal_body_composition0.60300578
122MP0002971_abnormal_brown_adipose0.60236227
123MP0001661_extended_life_span0.57555455
124MP0002928_abnormal_bile_duct0.55450677
125MP0009643_abnormal_urine_homeostasis0.53262289
126MP0001324_abnormal_eye_pigmentation0.52181125
127MP0000598_abnormal_liver_morphology0.49151445
128MP0006035_abnormal_mitochondrial_morpho0.48372230
129MP0002269_muscular_atrophy0.46371122
130MP0003699_abnormal_female_reproductive0.45865425
131MP0009642_abnormal_blood_homeostasis0.45068508
132MP0009115_abnormal_fat_cell0.44324920
133MP0008995_early_reproductive_senescence0.39756188
134MP0000358_abnormal_cell_content/0.39230466
135MP0005377_hearing/vestibular/ear_phenot0.37788924
136MP0003878_abnormal_ear_physiology0.37788924
137MP0004130_abnormal_muscle_cell0.37511572
138MP0004036_abnormal_muscle_relaxation0.36914662
139MP0005535_abnormal_body_temperature0.36827397
140MP0008469_abnormal_protein_level0.36197487
141MP0004043_abnormal_pH_regulation0.33749382
142MP0005376_homeostasis/metabolism_phenot0.32748693
143MP0005334_abnormal_fat_pad0.31871455
144MP0009763_increased_sensitivity_to0.31392658
145MP0005551_abnormal_eye_electrophysiolog0.31186354
146MP0002078_abnormal_glucose_homeostasis0.30988972
147MP0001545_abnormal_hematopoietic_system0.28182113
148MP0005397_hematopoietic_system_phenotyp0.28182113
149MP0003953_abnormal_hormone_level0.26641129
150MP0005266_abnormal_metabolism0.26454371
151MP0003656_abnormal_erythrocyte_physiolo0.26130290
152MP0002822_catalepsy0.25537833
153MP0002295_abnormal_pulmonary_circulatio0.24695638
154MP0002736_abnormal_nociception_after0.23429229
155MP0009672_abnormal_birth_weight0.22913517
156MP0009046_muscle_twitch0.22902507
157MP0002136_abnormal_kidney_physiology0.22795268
158MP0003186_abnormal_redox_activity0.22350844
159MP0003633_abnormal_nervous_system0.21656211
160MP0003959_abnormal_lean_body0.20666978
161MP0001119_abnormal_female_reproductive0.20057046
162MP0000639_abnormal_adrenal_gland0.19645953
163MP0005375_adipose_tissue_phenotype0.19429477
164MP0008961_abnormal_basal_metabolism0.19395701
165MP0002796_impaired_skin_barrier0.19030055
166MP0005084_abnormal_gallbladder_morpholo0.18329419
167MP0003942_abnormal_urinary_system0.18220565
168MP0001293_anophthalmia0.17760314
169MP0005253_abnormal_eye_physiology0.17634211
170MP0003950_abnormal_plasma_membrane0.17480680

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.42802560
2Abnormal respiratory epithelium morphology (HP:0012253)8.36573672
3Abnormal respiratory motile cilium morphology (HP:0005938)8.36573672
4Chronic bronchitis (HP:0004469)6.93666019
5Rhinitis (HP:0012384)6.92306091
6Infertility (HP:0000789)6.80974908
7Abnormal ciliary motility (HP:0012262)6.34185757
8Nasal polyposis (HP:0100582)6.05467448
9Abnormality of the nasal mucosa (HP:0000433)4.97302165
10Male infertility (HP:0003251)4.45190792
11Reticulocytosis (HP:0001923)4.37180807
12Truncus arteriosus (HP:0001660)4.36424465
13Bronchitis (HP:0012387)4.21754128
14Bronchiectasis (HP:0002110)3.99267985
15Abnormality of glycolysis (HP:0004366)3.93971411
16Cortical dysplasia (HP:0002539)3.90020653
17Hyperthyroidism (HP:0000836)3.71713831
18Nephronophthisis (HP:0000090)3.65653866
19Abnormality of reticulocytes (HP:0004312)3.58766341
20Abnormality of the heme biosynthetic pathway (HP:0010472)3.53107655
21Increased serum pyruvate (HP:0003542)3.51380881
22Abnormal spermatogenesis (HP:0008669)3.51370481
23Abnormal gallbladder physiology (HP:0012438)3.39146016
24Cholecystitis (HP:0001082)3.39146016
25Abnormal mitochondria in muscle tissue (HP:0008316)3.36324557
26Abnormal number of erythroid precursors (HP:0012131)3.20794119
27Recurrent otitis media (HP:0000403)3.20010223
28Increased intramyocellular lipid droplets (HP:0012240)3.11839408
29Acute necrotizing encephalopathy (HP:0006965)3.07125577
30Hepatocellular necrosis (HP:0001404)3.04686189
31Decreased activity of mitochondrial respiratory chain (HP:0008972)3.03848692
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.03848692
33Increased muscle lipid content (HP:0009058)2.99971954
34Recurrent sinusitis (HP:0011108)2.99911861
35Cholelithiasis (HP:0001081)2.96485825
36Abnormality of cells of the erythroid lineage (HP:0012130)2.95507530
37Mitochondrial inheritance (HP:0001427)2.91549578
38Impulsivity (HP:0100710)2.87405891
39Acute encephalopathy (HP:0006846)2.86347666
40Retinal dysplasia (HP:0007973)2.79207571
41Seborrheic dermatitis (HP:0001051)2.76284284
42Upper limb muscle weakness (HP:0003484)2.76194678
43Abnormality of the renal medulla (HP:0100957)2.73823796
44Tubulointerstitial nephritis (HP:0001970)2.67332558
45Increased CSF lactate (HP:0002490)2.67040217
46Renal Fanconi syndrome (HP:0001994)2.65042751
47Deep venous thrombosis (HP:0002625)2.65031334
48Abnormal gallbladder morphology (HP:0012437)2.64629127
49Lipid accumulation in hepatocytes (HP:0006561)2.61076135
50Intrahepatic cholestasis (HP:0001406)2.61022622
51Hypercholesterolemia (HP:0003124)2.51256798
52Gonadotropin excess (HP:0000837)2.50804984
53Increased hepatocellular lipid droplets (HP:0006565)2.50762428
54Hypertensive crisis (HP:0100735)2.50282877
55Tubulointerstitial abnormality (HP:0001969)2.46407585
56Microvesicular hepatic steatosis (HP:0001414)2.46293086
57Hepatic necrosis (HP:0002605)2.45211709
58Atelectasis (HP:0100750)2.45106707
59Abnormality of aromatic amino acid family metabolism (HP:0004338)2.44681698
60Bowel incontinence (HP:0002607)2.43738863
61Abnormality of the gallbladder (HP:0005264)2.43087952
62Hemorrhage of the eye (HP:0011885)2.41393043
63Recurrent bronchitis (HP:0002837)2.40479534
64Hand muscle atrophy (HP:0009130)2.38028788
65Abnormality of the tricuspid valve (HP:0001702)2.37515382
66Azoospermia (HP:0000027)2.36395581
67Abnormal large intestine physiology (HP:0012700)2.36337457
68Lactic acidosis (HP:0003128)2.35467050
69Hypoparathyroidism (HP:0000829)2.34154937
70Spastic tetraparesis (HP:0001285)2.33729186
71Tubular atrophy (HP:0000092)2.32236846
72Increased serum lactate (HP:0002151)2.29285271
73Broad distal phalanx of finger (HP:0009836)2.28006942
74Abnormally folded helix (HP:0008544)2.26694316
75Emotional lability (HP:0000712)2.25465523
76Exercise intolerance (HP:0003546)2.25078883
77Hypobetalipoproteinemia (HP:0003563)2.24702095
78Complement deficiency (HP:0004431)2.24377645
79Hyperbilirubinemia (HP:0002904)2.24276667
80Abnormality of monocarboxylic acid metabolism (HP:0010996)2.21257482
81Prolonged partial thromboplastin time (HP:0003645)2.18087927
82Insomnia (HP:0100785)2.15713044
83Progressive microcephaly (HP:0000253)2.14785231
84Abnormality of the aortic arch (HP:0012303)2.12489919
85Tubulointerstitial fibrosis (HP:0005576)2.10918062
86Cerebral edema (HP:0002181)2.09224098
87Overfolded helix (HP:0000396)2.08884970
88Progressive macrocephaly (HP:0004481)2.08555533
89Multiple enchondromatosis (HP:0005701)2.07681971
90Xanthomatosis (HP:0000991)2.06855479
91Birth length less than 3rd percentile (HP:0003561)2.04635349
92Type I transferrin isoform profile (HP:0003642)2.03604839
93Bile duct proliferation (HP:0001408)2.03344423
94Abnormal biliary tract physiology (HP:0012439)2.03344423
95Upper limb amyotrophy (HP:0009129)2.02357980
96Distal upper limb amyotrophy (HP:0007149)2.02357980
97Dyschromatopsia (HP:0007641)2.01370979
98Dynein arm defect of respiratory motile cilia (HP:0012255)12.2830742
99Absent/shortened dynein arms (HP:0200106)12.2830742
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0067802
101Premature skin wrinkling (HP:0100678)1.99768526
102Ragged-red muscle fibers (HP:0003200)1.99233049
103Neurofibrillary tangles (HP:0002185)1.96178841
104Vascular calcification (HP:0004934)1.96085182
105Cerebral hypomyelination (HP:0006808)1.95155896
106Disproportionate tall stature (HP:0001519)1.95136525
107Decreased central vision (HP:0007663)1.94990779
108Muscle fiber atrophy (HP:0100295)1.94771456
109Cerebral palsy (HP:0100021)1.93615569
110Reticulocytopenia (HP:0001896)1.93224689
111Abnormality of midbrain morphology (HP:0002418)1.91381633
112Molar tooth sign on MRI (HP:0002419)1.91381633
113Peripheral hypomyelination (HP:0007182)1.89244365
114Hypoplastic pelvis (HP:0008839)1.88348595
115Poor suck (HP:0002033)1.87857194
116Pallor (HP:0000980)1.87842215
117Choroideremia (HP:0001139)1.86023206
118Degeneration of anterior horn cells (HP:0002398)1.85183246
119Abnormality of the anterior horn cell (HP:0006802)1.85183246
120Ketosis (HP:0001946)1.85145351
121Horseshoe kidney (HP:0000085)1.84928422
122Abnormality of the renal cortex (HP:0011035)1.84737367
123Abnormality of the labia minora (HP:0012880)1.84152895
124Myokymia (HP:0002411)1.83721780
125Hypolipoproteinemia (HP:0010981)1.82824287
126Abnormality of complement system (HP:0005339)1.79688482
127Short 5th finger (HP:0009237)1.79115416
128Long foot (HP:0001833)1.78570741
129Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76994081
130Nonimmune hydrops fetalis (HP:0001790)1.76848180
131Abnormality of the lower motor neuron (HP:0002366)1.75337182
132Delayed CNS myelination (HP:0002188)1.74706943
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74585397
134Hypoalphalipoproteinemia (HP:0003233)1.74324689
135Rough bone trabeculation (HP:0100670)1.74051109
136Achilles tendon contracture (HP:0001771)1.73592291
1373-Methylglutaconic aciduria (HP:0003535)1.73368428
138Cardiovascular calcification (HP:0011915)1.72853161
139Medial flaring of the eyebrow (HP:0010747)1.71200385
140Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.71048791
141Respiratory difficulties (HP:0002880)1.70472177
142Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70211872
143Progressive muscle weakness (HP:0003323)1.69853379
144Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.69696675
145Malnutrition (HP:0004395)1.68382976
146Epidermoid cyst (HP:0200040)1.66755591
147Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.65600417
148Respiratory failure (HP:0002878)1.64869582
149Abnormal drinking behavior (HP:0030082)1.64221585
150Polydipsia (HP:0001959)1.64221585
151Ileus (HP:0002595)1.63676247
152Optic nerve coloboma (HP:0000588)1.62971445
153Myoglobinuria (HP:0002913)1.62955604
154Aplasia/Hypoplasia of the earlobes (HP:0009906)1.62758568
155Abnormality of renal excretion (HP:0011036)1.62103708
156Cerebral inclusion bodies (HP:0100314)1.60789734
157Aplasia/Hypoplasia of the thymus (HP:0010515)1.60630803
158Abnormal hemoglobin (HP:0011902)1.59989814
159Patellar aplasia (HP:0006443)1.59921681
160Hyperlipoproteinemia (HP:0010980)1.59192066
161Stage 5 chronic kidney disease (HP:0003774)1.58942243
162Absent epiphyses (HP:0010577)1.57991909
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57991909
164Patellar dislocation (HP:0002999)1.57397399
165Brushfield spots (HP:0001088)1.57373162
166Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.55840517
167Congenital hepatic fibrosis (HP:0002612)1.55344031
168Heterotopia (HP:0002282)1.54212453
169Postaxial foot polydactyly (HP:0001830)1.53195414
170Fibular hypoplasia (HP:0003038)1.49592064
171Short ribs (HP:0000773)1.44922268
172Abnormal urine output (HP:0012590)1.44426833
173Abnormality of aspartate family amino acid metabolism (HP:0010899)1.44197929
174Congenital malformation of the right heart (HP:0011723)1.42861155
175Double outlet right ventricle (HP:0001719)1.42861155
176Asymmetric septal hypertrophy (HP:0001670)1.42820393
177Global brain atrophy (HP:0002283)1.42565711
178Rhabdomyolysis (HP:0003201)1.41366624
179Bell-shaped thorax (HP:0001591)1.41179035
180Hyperammonemia (HP:0001987)1.36555376
181Exercise-induced myalgia (HP:0003738)1.35812007
182Abnormality of sulfur amino acid metabolism (HP:0004339)1.35692765
183Fat malabsorption (HP:0002630)1.35188948
184Stroke (HP:0001297)1.34373601
185Short femoral neck (HP:0100864)1.33618405
186Joint hemorrhage (HP:0005261)1.32477751
187Loss of speech (HP:0002371)1.31349610
188Retinal atrophy (HP:0001105)1.29333007
189Acanthocytosis (HP:0001927)1.28994263
190Abnormality of methionine metabolism (HP:0010901)1.28700823
191Impaired proprioception (HP:0010831)1.28447105
192Abnormality of glutamine family amino acid metabolism (HP:0010902)1.27683725
193Spontaneous abortion (HP:0005268)1.24151600
194Abnormality of vision evoked potentials (HP:0000649)1.21430217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.62435094
2PDK47.62435094
3TESK16.86953013
4PRKD35.61372980
5ICK4.96044792
6PDK24.95623267
7NME23.14540046
8VRK22.91093490
9BUB12.60439371
10PIM22.52897976
11SRPK12.48117958
12PTK2B2.25316958
13WNK42.18716567
14ARAF2.18172916
15KDR2.14151349
16MAP2K72.08321135
17STK381.99479507
18STK391.97356679
19DYRK1B1.84041487
20RAF11.82944551
21MAP4K21.77977348
22CDC71.76099445
23PLK41.75124956
24EIF2AK11.72663774
25NEK11.65237452
26LIMK11.64016322
27CDK191.59838514
28STK161.58575961
29NEK21.53652812
30PNCK1.53359797
31RPS6KA41.38333739
32BCR1.37458294
33KSR21.31308247
34PDK11.27298050
35CSNK1G31.27175413
36SIK21.21116909
37DYRK21.20444621
38CLK11.18504762
39AURKA1.17667568
40NME11.15985219
41MAP3K81.15872295
42SMG11.12532037
43IRAK31.12062857
44SCYL21.11166590
45BRSK11.06985385
46MAPK151.05952469
47CSNK1A1L1.05226157
48TRIM281.01538641
49PLK10.95583549
50NTRK10.92003953
51CDK70.91031226
52PDPK10.90311801
53MINK10.86519986
54CDK140.84716914
55DYRK30.84328829
56PINK10.82701962
57CSNK1G20.82553025
58TSSK60.79379616
59IRAK10.78680447
60NTRK30.78651377
61TYRO30.78562045
62MAP3K110.77784545
63BCKDK0.75517024
64MAP3K40.75034612
65SIK30.74278804
66BMX0.73920335
67TAOK20.70465581
68VRK10.69261822
69WNK10.67929833
70AURKB0.67396477
71STK30.65596005
72ILK0.65571599
73RPS6KA50.65251937
74EEF2K0.64462286
75CSNK1G10.61523392
76CDK20.60943008
77NUAK10.60107998
78FLT30.59426616
79PASK0.59243364
80MAP3K60.58127219
81MAP2K60.56398686
82TESK20.55552765
83IRAK20.55360902
84STK38L0.55144128
85CCNB10.54830410
86DAPK10.53979368
87CDK10.53629236
88PLK30.52425237
89CAMK1G0.48735616
90MAP3K100.48544113
91CSNK2A20.47692220
92SIK10.45836132
93TTK0.45743983
94PKN20.45723855
95RIPK40.44647273
96MATK0.44520553
97RPS6KB20.43764430
98AKT20.42546753
99PRKCG0.42506904
100LRRK20.40393149
101FGFR40.40347669
102RPS6KA20.40206316
103PBK0.38977553
104ERN10.38922135
105STK40.37313427
106TRIB30.35718207
107PRKCZ0.35608702
108NTRK20.35342516
109DAPK30.34661566
110PAK60.33760516
111PRKAA10.33690162
112LMTK20.33646173
113CHEK20.33468940
114MTOR0.32855277
115CAMKK10.30861800
116MUSK0.29699060
117MST1R0.29565843
118PAK20.27005467
119PAK10.26276353
120MARK20.26015157
121PRKCQ0.24884520
122CHEK10.22335499
123RPS6KB10.21269957
124PAK40.17562161
125PRKG20.16613807
126PRKACG0.16583871
127ATM0.15867855
128CDK60.14498930
129CSF1R0.14193967
130ERBB40.12916419
131EPHB10.12841591
132PIK3CG0.12338923
133INSRR0.11855299
134MARK30.10437890
135RPS6KA10.08512306
136NEK60.08445619
137PTK60.08438073
138ATR0.08250157
139MAPKAPK50.08097699
140MAP2K40.06271485
141MAPK40.05562303
142CSNK2A10.05342080
143PKN10.05335995
144PRKCA0.05028883
145CSK0.05022516
146PRKAA20.03870451
147PRKCD0.03530015
148CDK150.03505289
149PRKG10.03493513
150STK110.03296912
151EGFR0.03217145
152GSK3A0.03143183
153CAMK2A0.02117033
154PRKCB0.02111247
155TAOK30.01486495
156GSK3B0.01149470
157CDK40.01099975
158PIM10.01072065
159STK100.00691004
160CDK180.00273591
161FGFR2-0.0156954
162PRKACA-0.0132344
163RPS6KA3-0.0120342
164MAP3K5-0.0104854
165CSNK1D-0.0087348
166TBK1-0.0073851
167BRAF-0.0061818
168MAP3K3-0.0059855
169CDK11A-0.0022541

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.42389970
2Fatty acid biosynthesis_Homo sapiens_hsa000613.39189104
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.24943047
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.16955442
5Pyruvate metabolism_Homo sapiens_hsa006203.08869217
6Proteasome_Homo sapiens_hsa030503.02877791
7Propanoate metabolism_Homo sapiens_hsa006402.96944245
8Base excision repair_Homo sapiens_hsa034102.88769667
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.88696903
10Vitamin B6 metabolism_Homo sapiens_hsa007502.81472909
11Ribosome_Homo sapiens_hsa030102.73589094
12Fatty acid degradation_Homo sapiens_hsa000712.65282361
13Mismatch repair_Homo sapiens_hsa034302.53697963
14Oxidative phosphorylation_Homo sapiens_hsa001902.51780025
15Parkinsons disease_Homo sapiens_hsa050122.49720849
16Spliceosome_Homo sapiens_hsa030402.46730380
17PPAR signaling pathway_Homo sapiens_hsa033202.44864820
18Selenocompound metabolism_Homo sapiens_hsa004502.37982313
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.30498067
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22539504
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21036291
22RNA polymerase_Homo sapiens_hsa030202.20025988
23Fatty acid metabolism_Homo sapiens_hsa012122.18467812
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17164178
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16570729
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.15249258
27Nitrogen metabolism_Homo sapiens_hsa009102.11821211
28Linoleic acid metabolism_Homo sapiens_hsa005912.10817034
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05209545
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00596550
31Pyrimidine metabolism_Homo sapiens_hsa002401.95167983
32Huntingtons disease_Homo sapiens_hsa050161.93514370
33RNA transport_Homo sapiens_hsa030131.93349935
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88268562
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84657102
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.77616656
37Fat digestion and absorption_Homo sapiens_hsa049751.77487241
38Chemical carcinogenesis_Homo sapiens_hsa052041.76681184
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76619574
40Complement and coagulation cascades_Homo sapiens_hsa046101.73733727
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.71893617
42Glycerolipid metabolism_Homo sapiens_hsa005611.71171322
43Glucagon signaling pathway_Homo sapiens_hsa049221.67705991
44Carbon metabolism_Homo sapiens_hsa012001.62549182
45Arginine biosynthesis_Homo sapiens_hsa002201.62543714
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60589004
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58262951
48Homologous recombination_Homo sapiens_hsa034401.57603763
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.55545436
50Tryptophan metabolism_Homo sapiens_hsa003801.53380310
51Nucleotide excision repair_Homo sapiens_hsa034201.50516282
52Bile secretion_Homo sapiens_hsa049761.47480284
53Cell cycle_Homo sapiens_hsa041101.47477733
54Alzheimers disease_Homo sapiens_hsa050101.43818063
55Peroxisome_Homo sapiens_hsa041461.43251964
56Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39033911
57Pentose phosphate pathway_Homo sapiens_hsa000301.32697799
58Biosynthesis of amino acids_Homo sapiens_hsa012301.31995149
59mRNA surveillance pathway_Homo sapiens_hsa030151.30157091
60One carbon pool by folate_Homo sapiens_hsa006701.26610482
61Fanconi anemia pathway_Homo sapiens_hsa034601.24135762
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.23875185
63Fructose and mannose metabolism_Homo sapiens_hsa000511.23684927
64Glycerophospholipid metabolism_Homo sapiens_hsa005641.22419622
65Sulfur metabolism_Homo sapiens_hsa009201.21843951
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18568913
67Retinol metabolism_Homo sapiens_hsa008301.17562381
68Butanoate metabolism_Homo sapiens_hsa006501.13787595
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12123699
70ABC transporters_Homo sapiens_hsa020101.12094667
71Histidine metabolism_Homo sapiens_hsa003401.07969199
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07725235
73Glutathione metabolism_Homo sapiens_hsa004801.07660414
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05513199
75RNA degradation_Homo sapiens_hsa030180.95397142
76N-Glycan biosynthesis_Homo sapiens_hsa005100.91694890
77Galactose metabolism_Homo sapiens_hsa000520.91598647
78Synaptic vesicle cycle_Homo sapiens_hsa047210.91487320
79Phenylalanine metabolism_Homo sapiens_hsa003600.89331228
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87699216
81Folate biosynthesis_Homo sapiens_hsa007900.86487647
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84694162
83Vibrio cholerae infection_Homo sapiens_hsa051100.84504910
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.83996308
85beta-Alanine metabolism_Homo sapiens_hsa004100.80103859
86Staphylococcus aureus infection_Homo sapiens_hsa051500.79119456
87Starch and sucrose metabolism_Homo sapiens_hsa005000.79106724
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75341957
89Ether lipid metabolism_Homo sapiens_hsa005650.73240068
90Protein export_Homo sapiens_hsa030600.71416804
91Acute myeloid leukemia_Homo sapiens_hsa052210.70350643
92Tyrosine metabolism_Homo sapiens_hsa003500.69735002
93Basal transcription factors_Homo sapiens_hsa030220.68737530
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.68338146
95Non-homologous end-joining_Homo sapiens_hsa034500.68321350
96Dorso-ventral axis formation_Homo sapiens_hsa043200.67915884
97Mineral absorption_Homo sapiens_hsa049780.67521210
98Fatty acid elongation_Homo sapiens_hsa000620.65611758
99Steroid biosynthesis_Homo sapiens_hsa001000.64928579
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.61552968
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60721113
102Caffeine metabolism_Homo sapiens_hsa002320.58404552
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57511388
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56866565
105Shigellosis_Homo sapiens_hsa051310.56631624
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55804001
107Amphetamine addiction_Homo sapiens_hsa050310.55738594
108Metabolic pathways_Homo sapiens_hsa011000.54822877
109Epstein-Barr virus infection_Homo sapiens_hsa051690.54597046
110Thyroid cancer_Homo sapiens_hsa052160.54441294
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53951400
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52269443
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52093799
114Vitamin digestion and absorption_Homo sapiens_hsa049770.51564118
115Bladder cancer_Homo sapiens_hsa052190.50779214
116Arginine and proline metabolism_Homo sapiens_hsa003300.50154164
117Sulfur relay system_Homo sapiens_hsa041220.49298077
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46865491
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44242514
120Arachidonic acid metabolism_Homo sapiens_hsa005900.44015424
121Notch signaling pathway_Homo sapiens_hsa043300.41944741
122Viral carcinogenesis_Homo sapiens_hsa052030.38164948
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.36965974
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36628216
125Oocyte meiosis_Homo sapiens_hsa041140.35489582
126Cardiac muscle contraction_Homo sapiens_hsa042600.34800108
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33250697
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.32799875
129AMPK signaling pathway_Homo sapiens_hsa041520.32374712
130Lysine degradation_Homo sapiens_hsa003100.30811034
131Thyroid hormone synthesis_Homo sapiens_hsa049180.30426748
132p53 signaling pathway_Homo sapiens_hsa041150.30171371
133Antigen processing and presentation_Homo sapiens_hsa046120.28351063
134Purine metabolism_Homo sapiens_hsa002300.27668602
135Systemic lupus erythematosus_Homo sapiens_hsa053220.26683281
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.25621642
137Protein digestion and absorption_Homo sapiens_hsa049740.23761742
138Renin secretion_Homo sapiens_hsa049240.23379627
139Alcoholism_Homo sapiens_hsa050340.23342893
140Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23276536
141Chronic myeloid leukemia_Homo sapiens_hsa052200.22815572
142Hedgehog signaling pathway_Homo sapiens_hsa043400.22468879
143Renin-angiotensin system_Homo sapiens_hsa046140.22144072
144Colorectal cancer_Homo sapiens_hsa052100.21663387
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20372057
146Insulin resistance_Homo sapiens_hsa049310.19422154
147VEGF signaling pathway_Homo sapiens_hsa043700.17257124
148Insulin secretion_Homo sapiens_hsa049110.16639332
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16542698
150Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.16486977
151Other glycan degradation_Homo sapiens_hsa005110.16156984
1522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.15674970
153HIF-1 signaling pathway_Homo sapiens_hsa040660.15029233
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14583479
155Collecting duct acid secretion_Homo sapiens_hsa049660.14294813
156Apoptosis_Homo sapiens_hsa042100.13748666

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