SPATS2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)5.45390527
2polyketide metabolic process (GO:0030638)5.45390527
3doxorubicin metabolic process (GO:0044598)5.45390527
4bone trabecula formation (GO:0060346)4.44624305
5proline transport (GO:0015824)4.35276131
6regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.94360406
7notochord development (GO:0030903)3.92245081
8cell adhesion mediated by integrin (GO:0033627)3.84638909
9axonal fasciculation (GO:0007413)3.69345451
10aminoglycoside antibiotic metabolic process (GO:0030647)3.59577340
11regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.58327876
12skin morphogenesis (GO:0043589)3.58048254
13neuron cell-cell adhesion (GO:0007158)3.57539063
14vocalization behavior (GO:0071625)3.56004282
15chondrocyte proliferation (GO:0035988)3.49272413
16hemidesmosome assembly (GO:0031581)3.44679160
17regulation of response to osmotic stress (GO:0047484)3.44670375
18somite rostral/caudal axis specification (GO:0032525)3.43899937
19synaptic vesicle maturation (GO:0016188)3.41010749
20maintenance of protein location in nucleus (GO:0051457)3.39923445
21neuron recognition (GO:0008038)3.38937843
22phenol-containing compound catabolic process (GO:0019336)3.35909664
23regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.35234289
24negative regulation of epidermis development (GO:0045683)3.33707264
25calcium-mediated signaling using intracellular calcium source (GO:0035584)3.25090619
26negative regulation of fibrinolysis (GO:0051918)3.20345678
27head development (GO:0060322)3.18427537
28protein carboxylation (GO:0018214)3.17508188
29peptidyl-glutamic acid carboxylation (GO:0017187)3.17508188
30lateral sprouting from an epithelium (GO:0060601)3.16843194
31regulation of fibrinolysis (GO:0051917)3.16369546
32endodermal cell differentiation (GO:0035987)3.13704793
33fibrinolysis (GO:0042730)3.08702777
34cell migration in hindbrain (GO:0021535)3.08077604
35mitochondrion distribution (GO:0048311)3.05507645
36endothelial cell morphogenesis (GO:0001886)3.05379536
37cardiovascular system development (GO:0072358)3.03383715
38retina vasculature morphogenesis in camera-type eye (GO:0061299)3.00046312
39desmosome organization (GO:0002934)2.99467589
40negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.96554642
41negative regulation of chondrocyte differentiation (GO:0032331)2.96187351
42lung vasculature development (GO:0060426)2.96137906
43cell proliferation involved in metanephros development (GO:0072203)2.95808716
44mesenchymal-epithelial cell signaling (GO:0060638)2.94505248
45collagen fibril organization (GO:0030199)2.94437225
46intestinal cholesterol absorption (GO:0030299)2.93986360
47negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.93583343
48axon extension (GO:0048675)2.93216754
49glutamate secretion (GO:0014047)2.93036719
50glomerular basement membrane development (GO:0032836)2.90503742
51regulation of plasminogen activation (GO:0010755)2.90051162
52regulation of mammary gland epithelial cell proliferation (GO:0033599)2.89593719
53layer formation in cerebral cortex (GO:0021819)2.88941253
54positive regulation of smoothened signaling pathway (GO:0045880)2.88771963
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.87991393
56regulation of short-term neuronal synaptic plasticity (GO:0048172)2.87852766
57dendritic spine morphogenesis (GO:0060997)2.86384981
58planar cell polarity pathway involved in neural tube closure (GO:0090179)2.86364056
59metanephric mesenchyme development (GO:0072075)2.86231268
60regulation of hippo signaling (GO:0035330)2.84563872
61axon extension involved in axon guidance (GO:0048846)2.83585426
62neuron projection extension involved in neuron projection guidance (GO:1902284)2.83585426
63cellular glucuronidation (GO:0052695)2.79783740
64gap junction assembly (GO:0016264)2.79700374
65protein localization to synapse (GO:0035418)2.79155043
66regulation of cilium movement (GO:0003352)2.76590516
67muscle cell migration (GO:0014812)2.73122378
68muscle organ morphogenesis (GO:0048644)2.71075732
69cell fate commitment involved in formation of primary germ layer (GO:0060795)2.70777844
70central nervous system projection neuron axonogenesis (GO:0021952)2.68389605
71kidney mesenchyme development (GO:0072074)2.68181842
72positive regulation of synapse assembly (GO:0051965)2.68163603
73basement membrane organization (GO:0071711)2.66925976
74postsynaptic membrane organization (GO:0001941)2.66542905
75epithelial cell-cell adhesion (GO:0090136)2.66045017
76negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.65465684
77ventricular system development (GO:0021591)2.64163332
78regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.63966407
79positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.63656749
80regulation of MHC class I biosynthetic process (GO:0045343)2.62751468
81negative regulation of coagulation (GO:0050819)2.62506708
82lung epithelium development (GO:0060428)2.62471033
83synaptic vesicle exocytosis (GO:0016079)2.62324767
84intestinal absorption (GO:0050892)2.60868980
85positive regulation of synapse maturation (GO:0090129)2.60866555
86negative regulation of catenin import into nucleus (GO:0035414)2.60813924
87uronic acid metabolic process (GO:0006063)2.58888465
88glucuronate metabolic process (GO:0019585)2.58888465
89substrate adhesion-dependent cell spreading (GO:0034446)2.57599539
90negative regulation of axon extension involved in axon guidance (GO:0048843)2.57417342
91renal filtration (GO:0097205)2.56743411
92negative regulation of wound healing (GO:0061045)2.56456477
93negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.55040041
94regulation of protein activation cascade (GO:2000257)2.54940520
95exploration behavior (GO:0035640)2.54000930
96positive regulation of extracellular matrix organization (GO:1903055)2.53876454
97negative regulation of smoothened signaling pathway (GO:0045879)2.53385042
98paraxial mesoderm development (GO:0048339)2.51748149
99plasma membrane repair (GO:0001778)2.51142862
100extracellular fibril organization (GO:0043206)2.50692871
101negative regulation of protein localization to cell surface (GO:2000009)2.49820606
102microtubule severing (GO:0051013)2.49353685
103presynaptic membrane assembly (GO:0097105)2.49241709
104tonic smooth muscle contraction (GO:0014820)2.49132125
105histone H4-K5 acetylation (GO:0043981)2.49096202
106histone H4-K8 acetylation (GO:0043982)2.49096202
107endocardial cushion development (GO:0003197)2.48553807
108mesodermal cell differentiation (GO:0048333)2.48393685
109vitamin A metabolic process (GO:0006776)2.48277833
110regulation of complement activation (GO:0030449)2.47132581
111branching involved in mammary gland duct morphogenesis (GO:0060444)2.47088671
112detection of temperature stimulus (GO:0016048)2.46409840
113middle ear morphogenesis (GO:0042474)2.45781732
114innervation (GO:0060384)2.45549486
115body morphogenesis (GO:0010171)2.44967342
116regulation of glutamate receptor signaling pathway (GO:1900449)2.44943446
117regulation of pigment cell differentiation (GO:0050932)2.44611052
118negative regulation of blood coagulation (GO:0030195)2.44088455
119negative regulation of hemostasis (GO:1900047)2.44088455
120cullin deneddylation (GO:0010388)2.43911417
121primitive streak formation (GO:0090009)2.43203659
122convergent extension (GO:0060026)2.42929717
123negative regulation of potassium ion transmembrane transport (GO:1901380)2.41821063
124negative regulation of keratinocyte proliferation (GO:0010839)2.41535372
125positive regulation of axon extension (GO:0045773)2.40964725
126regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40717981
127negative regulation of systemic arterial blood pressure (GO:0003085)2.40461357
128inner ear receptor cell development (GO:0060119)2.40413140
129cerebellar granule cell differentiation (GO:0021707)2.40342143
130anterior/posterior axis specification, embryo (GO:0008595)2.39932287
131regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.39600505
132neuron projection extension (GO:1990138)2.39513567
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.39324435
134sequestering of extracellular ligand from receptor (GO:0035581)2.39066015
135positive regulation of osteoblast proliferation (GO:0033690)2.38110718
136substrate-dependent cell migration (GO:0006929)2.37382150
137response to muscle activity (GO:0014850)2.36934415
138establishment of tissue polarity (GO:0007164)2.36090438
139establishment of planar polarity (GO:0001736)2.36090438
140response to hepatocyte growth factor (GO:0035728)2.36045013
141cellular response to hepatocyte growth factor stimulus (GO:0035729)2.36045013
142glomerular visceral epithelial cell development (GO:0072015)2.35668475
143nucleotide-sugar biosynthetic process (GO:0009226)2.34694456
144cellular response to vitamin D (GO:0071305)2.34253655
145UDP-N-acetylglucosamine metabolic process (GO:0006047)2.33211952
146positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.33106531
147negative regulation of fatty acid transport (GO:2000192)2.32157894
148G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.32017633
149L-phenylalanine metabolic process (GO:0006558)2.31652086
150erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.31652086
151protein heterotrimerization (GO:0070208)2.31633693
152regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.30614343
153renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.30596068
154regulation of transforming growth factor beta2 production (GO:0032909)2.30364755
155anterior/posterior axis specification (GO:0009948)2.29957519
156cell migration involved in sprouting angiogenesis (GO:0002042)2.29833913
157primary alcohol catabolic process (GO:0034310)2.29000155
158regulation of metalloenzyme activity (GO:0048552)2.28813546
159response to dietary excess (GO:0002021)2.28551594
160Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.28343435
161outer ear morphogenesis (GO:0042473)2.28089181
162glomerular epithelial cell development (GO:0072310)2.27803749
163regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.26560930
164smooth muscle tissue development (GO:0048745)2.26146002
165regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.26066157
166negative regulation of protein activation cascade (GO:2000258)2.26056514
167presynaptic membrane organization (GO:0097090)2.25780510
168cell proliferation involved in kidney development (GO:0072111)2.25315939
169regulation of synapse assembly (GO:0051963)2.24100106
170auditory behavior (GO:0031223)2.23880723
171cellular response to vitamin (GO:0071295)2.23009862
172actin filament depolymerization (GO:0030042)2.22827258
173cochlea morphogenesis (GO:0090103)2.22703003
174locomotory exploration behavior (GO:0035641)2.21949916
175response to gravity (GO:0009629)2.21540357
176retinal metabolic process (GO:0042574)2.20736055
177negative regulation of axon guidance (GO:1902668)2.19986707
178negative regulation of lipase activity (GO:0060192)2.18553988
179regulation of bile acid biosynthetic process (GO:0070857)2.18499288
180lymphangiogenesis (GO:0001946)2.18377240
181keratinocyte proliferation (GO:0043616)2.15486876
182regulation of extracellular matrix disassembly (GO:0010715)2.14512343
183bundle of His cell to Purkinje myocyte communication (GO:0086069)2.13545227
184renal system process involved in regulation of blood volume (GO:0001977)2.13204094
185regulation of integrin-mediated signaling pathway (GO:2001044)2.13146057
186type B pancreatic cell proliferation (GO:0044342)2.12879776
187regulation of apoptotic cell clearance (GO:2000425)2.12687965
188artery smooth muscle contraction (GO:0014824)2.12543747
189positive regulation of fatty acid oxidation (GO:0046321)2.12331048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.28225676
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.63324174
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.55820925
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.55820925
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.55820925
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.43391165
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.21189075
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.83194888
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75145339
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75145339
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.73897855
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69280803
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65287459
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63208803
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.59467740
16CJUN_26792858_Chip-Seq_BT549_Human2.54523058
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54466928
18GBX2_23144817_ChIP-Seq_PC3_Human2.53090556
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.50893570
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44699618
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.42915693
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42650161
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41901908
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.36337212
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34159697
26EP300_21415370_ChIP-Seq_HL-1_Mouse2.23713248
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15470542
28TRIM28_21343339_ChIP-Seq_HEK293_Human2.12323048
29* RNF2_27304074_Chip-Seq_ESCs_Mouse2.05567189
30SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.02541987
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.90373253
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.89895056
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88510063
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84510996
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84106512
36SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.80735581
37TP53_16413492_ChIP-PET_HCT116_Human1.78961365
38SOX2_20726797_ChIP-Seq_SW620_Human1.78749618
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.74555525
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.73603770
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.72537895
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.71559428
43* BRD4_25478319_ChIP-Seq_HGPS_Human1.70434026
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68389595
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67384468
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67324710
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.65769065
48* RING1B_27294783_Chip-Seq_NPCs_Mouse1.65645947
49NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.65232473
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.64774965
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63749397
52RNF2_27304074_Chip-Seq_NSC_Mouse1.63629156
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.62294025
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.60953391
55CLOCK_20551151_ChIP-Seq_293T_Human1.59734188
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59686775
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.58657727
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58587423
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.58271184
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.58203604
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55498043
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55498043
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51858161
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48259091
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48259091
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47782366
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47379199
68* RING1B_27294783_Chip-Seq_ESCs_Mouse1.47057468
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45400021
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.43516333
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41884135
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40436892
73AR_21909140_ChIP-Seq_LNCAP_Human1.39907689
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39807099
75JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38902827
76GATA4_25053715_ChIP-Seq_YYC3_Human1.37227635
77PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35119658
78SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34219865
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32210119
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31484625
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31170324
82TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30495185
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30463496
84* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29969079
85NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.28964404
86REST_21632747_ChIP-Seq_MESCs_Mouse1.28673192
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.28625923
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28575281
89FOXO3_23340844_ChIP-Seq_DLD1_Human1.28136327
90* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27750625
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26409595
92* AHR_22903824_ChIP-Seq_MCF-7_Human1.26172092
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24179145
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23798616
95VDR_22108803_ChIP-Seq_LS180_Human1.23009046
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22971383
97* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22561296
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22482823
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22315523
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21457241
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20922900
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20208649
103TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.19828034
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.19749140
105* ARNT_22903824_ChIP-Seq_MCF-7_Human1.19195623
106CDX2_20551321_ChIP-Seq_CACO-2_Human1.19139339
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18271069
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17578272
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16748750
110CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16281884
111TCF4_18268006_ChIP-ChIP_LS174T_Human1.16201463
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.15916970
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15856626
114IGF1R_20145208_ChIP-Seq_DFB_Human1.15610131
115* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14232536
116SMAD3_21741376_ChIP-Seq_HESCs_Human1.13932141
117NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13374768
118RARB_27405468_Chip-Seq_BRAIN_Mouse1.13374630
119* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13080291
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10489303
121* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10260959
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10185630
123TP53_18474530_ChIP-ChIP_U2OS_Human1.09546572
124WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07998732
125SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07320437
126ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07167174
127* TP63_23658742_ChIP-Seq_EP156T_Human1.07044686
128* SMAD4_21799915_ChIP-Seq_A2780_Human1.05935907
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05700293
130HNF4A_19822575_ChIP-Seq_HepG2_Human1.04966229
131CDX2_22108803_ChIP-Seq_LS180_Human1.04847764
132REST_18959480_ChIP-ChIP_MESCs_Mouse1.04498602
133* FLI1_27457419_Chip-Seq_LIVER_Mouse1.04341999
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04311873
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03211813
136TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02967509
137* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01943493
138TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01865464
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01316437
140HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01252420
141TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01121894
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00109444
143DROSHA_22980978_ChIP-Seq_HELA_Human0.99888851
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99772666
145AR_19668381_ChIP-Seq_PC3_Human0.97152997
146SOX2_21211035_ChIP-Seq_LN229_Gbm0.96705650
147ISL1_27105846_Chip-Seq_CPCs_Mouse0.96586871
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96182238
149POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94936702
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94755126
151PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94417873
152SMAD_19615063_ChIP-ChIP_OVARY_Human0.93850771
153FUS_26573619_Chip-Seq_HEK293_Human0.93802149
154CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93594603
155GATA2_21666600_ChIP-Seq_HMVEC_Human0.93159707
156AR_21572438_ChIP-Seq_LNCaP_Human0.92776012
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92555325
158YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92094299
159TAF15_26573619_Chip-Seq_HEK293_Human0.90555496
160* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90330117
161* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89354429
162KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88376933
163* GATA6_25053715_ChIP-Seq_YYC3_Human0.87469176
164* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86775553
165BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84876451
166EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84279971
167* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82663619
168* GATA3_24758297_ChIP-Seq_MCF-7_Human0.82464100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.15840336
2MP0003950_abnormal_plasma_membrane3.50471862
3MP0004858_abnormal_nervous_system2.78073882
4MP0005360_urolithiasis2.77249973
5MP0003880_abnormal_central_pattern2.48265998
6MP0009780_abnormal_chondrocyte_physiolo2.45617826
7MP0005503_abnormal_tendon_morphology2.43717496
8MP0003566_abnormal_cell_adhesion2.31636918
9MP0002254_reproductive_system_inflammat2.30366532
10MP0004859_abnormal_synaptic_plasticity2.30123067
11MP0005394_taste/olfaction_phenotype2.29724624
12MP0005499_abnormal_olfactory_system2.29724624
13MP0008438_abnormal_cutaneous_collagen2.28883699
14MP0002139_abnormal_hepatobiliary_system2.24012373
15MP0003121_genomic_imprinting2.20681410
16MP0003011_delayed_dark_adaptation2.04884043
17MP0010030_abnormal_orbit_morphology2.01788307
18MP0003938_abnormal_ear_development2.01728349
19MP0005085_abnormal_gallbladder_physiolo1.98969383
20MP0000049_abnormal_middle_ear1.97519730
21MP0008875_abnormal_xenobiotic_pharmacok1.95422906
22MP0004272_abnormal_basement_membrane1.93898091
23MP0005023_abnormal_wound_healing1.89860227
24MP0010368_abnormal_lymphatic_system1.87541188
25MP0000778_abnormal_nervous_system1.83815415
26MP0009250_abnormal_appendicular_skeleto1.80206611
27MP0005365_abnormal_bile_salt1.79960118
28MP0006054_spinal_hemorrhage1.73762347
29MP0002653_abnormal_ependyma_morphology1.73721948
30MP0003942_abnormal_urinary_system1.73704917
31MP0006292_abnormal_olfactory_placode1.71524507
32MP0003385_abnormal_body_wall1.70145157
33MP0003123_paternal_imprinting1.69655912
34MP0003890_abnormal_embryonic-extraembry1.68892136
35MP0003635_abnormal_synaptic_transmissio1.68673408
36MP0005623_abnormal_meninges_morphology1.68010164
37MP0004264_abnormal_extraembryonic_tissu1.65872737
38MP0004270_analgesia1.64599573
39MP0003755_abnormal_palate_morphology1.63316984
40MP0002233_abnormal_nose_morphology1.61380950
41MP0003705_abnormal_hypodermis_morpholog1.59918859
42MP0000762_abnormal_tongue_morphology1.57902706
43MP0005257_abnormal_intraocular_pressure1.57682698
44MP0002932_abnormal_joint_morphology1.57287558
45MP0003283_abnormal_digestive_organ1.55632128
46MP0005275_abnormal_skin_tensile1.54342356
47MP0005508_abnormal_skeleton_morphology1.51696022
48MP0003195_calcinosis1.48067249
49MP0000534_abnormal_ureter_morphology1.48017471
50MP0006276_abnormal_autonomic_nervous1.44970710
51MP0002089_abnormal_postnatal_growth/wei1.44720047
52MP0002060_abnormal_skin_morphology1.44103845
53MP0009840_abnormal_foam_cell1.43351518
54MP0001542_abnormal_bone_strength1.41900624
55MP0002063_abnormal_learning/memory/cond1.41266385
56MP0000749_muscle_degeneration1.40969009
57MP0002249_abnormal_larynx_morphology1.40540988
58MP0002332_abnormal_exercise_endurance1.38795351
59MP0002184_abnormal_innervation1.38669378
60MP0003252_abnormal_bile_duct1.38505114
61MP0002572_abnormal_emotion/affect_behav1.38098346
62MP0010386_abnormal_urinary_bladder1.36567157
63MP0001666_abnormal_nutrient_absorption1.32922018
64MP0008789_abnormal_olfactory_epithelium1.32465730
65MP0003935_abnormal_craniofacial_develop1.31505814
66MP0002734_abnormal_mechanical_nocicepti1.30641312
67MP0002108_abnormal_muscle_morphology1.29698859
68MP0000013_abnormal_adipose_tissue1.29561519
69MP0002896_abnormal_bone_mineralization1.29479255
70MP0001486_abnormal_startle_reflex1.28099261
71MP0003868_abnormal_feces_composition1.26966728
72MP0002116_abnormal_craniofacial_bone1.25130191
73MP0009046_muscle_twitch1.24610369
74MP0005595_abnormal_vascular_smooth1.23472276
75MP0000767_abnormal_smooth_muscle1.22659858
76MP0002295_abnormal_pulmonary_circulatio1.21186552
77MP0000428_abnormal_craniofacial_morphol1.20705942
78MP0000537_abnormal_urethra_morphology1.20631945
79MP0002064_seizures1.19568699
80MP0003937_abnormal_limbs/digits/tail_de1.18525365
81MP0009745_abnormal_behavioral_response1.18178212
82MP0002114_abnormal_axial_skeleton1.17355977
83MP0010352_gastrointestinal_tract_polyps1.16500842
84MP0003787_abnormal_imprinting1.16033646
85MP0000678_abnormal_parathyroid_gland1.15685501
86MP0003091_abnormal_cell_migration1.15491562
87MP0003137_abnormal_impulse_conducting1.13456158
88MP0003119_abnormal_digestive_system1.12856379
89MP0005332_abnormal_amino_acid1.12596968
90MP0005248_abnormal_Harderian_gland1.12516371
91MP0002127_abnormal_cardiovascular_syste1.10729912
92MP0005197_abnormal_uvea_morphology1.10255984
93MP0002876_abnormal_thyroid_physiology1.10102009
94MP0000751_myopathy1.09525162
95MP0000955_abnormal_spinal_cord1.08946939
96MP0002733_abnormal_thermal_nociception1.08161850
97MP0000432_abnormal_head_morphology1.06512468
98MP0005164_abnormal_response_to1.03284027
99MP0000462_abnormal_digestive_system1.02306812
100MP0001968_abnormal_touch/_nociception1.01839794
101MP0004019_abnormal_vitamin_homeostasis1.01746742
102MP0003861_abnormal_nervous_system1.00393235
103MP0002751_abnormal_autonomic_nervous1.00175084
104MP0003315_abnormal_perineum_morphology0.98884168
105MP0010329_abnormal_lipoprotein_level0.98799256
106MP0000538_abnormal_urinary_bladder0.98673170
107MP0000467_abnormal_esophagus_morphology0.98634554
108MP0002938_white_spotting0.98552713
109MP0000163_abnormal_cartilage_morphology0.97679611
110MP0001270_distended_abdomen0.94544416
111MP0001958_emphysema0.94397020
112MP0000631_abnormal_neuroendocrine_gland0.93159514
113MP0001849_ear_inflammation0.92936597
114MP0004133_heterotaxia0.92422559
115MP0002081_perinatal_lethality0.92327676
116MP0009384_cardiac_valve_regurgitation0.91180916
117MP0002272_abnormal_nervous_system0.89535946
118MP0004084_abnormal_cardiac_muscle0.88610140
119MP0002109_abnormal_limb_morphology0.88061899
120MP0000750_abnormal_muscle_regeneration0.87006335
121MP0002557_abnormal_social/conspecific_i0.86660264
122MP0005165_increased_susceptibility_to0.86265999
123MP0001970_abnormal_pain_threshold0.84690279
124MP0004085_abnormal_heartbeat0.82756289
125MP0000733_abnormal_muscle_development0.82009684
126MP0004145_abnormal_muscle_electrophysio0.81948856
127MP0003941_abnormal_skin_development0.80949049
128MP0001299_abnormal_eye_distance/0.80754327
129MP0001440_abnormal_grooming_behavior0.80681186
130MP0000026_abnormal_inner_ear0.80482496
131MP0002882_abnormal_neuron_morphology0.79892821
132MP0002752_abnormal_somatic_nervous0.79728194
133MP0001879_abnormal_lymphatic_vessel0.79273549
134MP0001293_anophthalmia0.79105242
135MP0002282_abnormal_trachea_morphology0.78489185
136MP0009697_abnormal_copulation0.78142963
137MP0001243_abnormal_dermal_layer0.77037051
138MP0003279_aneurysm0.75901473
139MP0005330_cardiomyopathy0.75670251
140MP0009053_abnormal_anal_canal0.75653659
141MP0001943_abnormal_respiration0.74220214
142MP0001661_extended_life_span0.74183903
143MP0001501_abnormal_sleep_pattern0.73483911
144MP0005620_abnormal_muscle_contractility0.72687130
145MP0003115_abnormal_respiratory_system0.72434990
146MP0000566_synostosis0.72314215
147MP0002067_abnormal_sensory_capabilities0.72229528
148MP0002168_other_aberrant_phenotype0.70493006
149MP0001915_intracranial_hemorrhage0.68763577
150MP0002697_abnormal_eye_size0.67642263
151MP0001756_abnormal_urination0.67138273
152MP0002909_abnormal_adrenal_gland0.66837269
153MP0000003_abnormal_adipose_tissue0.66384407
154MP0006138_congestive_heart_failure0.65915284
155MP0000579_abnormal_nail_morphology0.63881919
156MP0008775_abnormal_heart_ventricle0.62887984
157MP0001614_abnormal_blood_vessel0.62840095
158MP0004043_abnormal_pH_regulation0.62204407
159MP0000230_abnormal_systemic_arterial0.60834043
160MP0004215_abnormal_myocardial_fiber0.60435887

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.46689592
2Hepatoblastoma (HP:0002884)4.88835489
3Aortic dissection (HP:0002647)3.83034702
4Vascular tortuosity (HP:0004948)3.67497115
5Hyperventilation (HP:0002883)3.62678779
6Cardiovascular calcification (HP:0011915)3.62282990
7Popliteal pterygium (HP:0009756)3.53340787
8Arterial tortuosity (HP:0005116)3.46636328
9Vascular calcification (HP:0004934)3.45185577
10Deep venous thrombosis (HP:0002625)3.38413364
11Protrusio acetabuli (HP:0003179)3.20970230
12Soft skin (HP:0000977)3.17691657
13Pterygium (HP:0001059)3.07050033
14Follicular hyperkeratosis (HP:0007502)3.06325655
15Rib fusion (HP:0000902)3.04783630
16Abnormality of the lower motor neuron (HP:0002366)2.95204024
17Aortic aneurysm (HP:0004942)2.95055064
18Premature rupture of membranes (HP:0001788)2.84523924
19Hypochromic microcytic anemia (HP:0004840)2.72625021
20Amblyopia (HP:0000646)2.72494551
21Abnormality of proline metabolism (HP:0010907)2.71533394
22Hydroxyprolinuria (HP:0003080)2.71533394
23Type 1 muscle fiber predominance (HP:0003803)2.68636694
24Bifid tongue (HP:0010297)2.68467377
25Mildly elevated creatine phosphokinase (HP:0008180)2.64438186
26Epileptic encephalopathy (HP:0200134)2.57177848
27Abnormality of dentin (HP:0010299)2.55773449
28Abnormality of the phalanges of the hallux (HP:0010057)2.53190712
29Neonatal short-limb short stature (HP:0008921)2.52408812
30Mitral stenosis (HP:0001718)2.49580884
31Prolonged partial thromboplastin time (HP:0003645)2.47522673
32Abnormality of the pubic bones (HP:0003172)2.45624867
33Renal duplication (HP:0000075)2.42822603
34Embryonal renal neoplasm (HP:0011794)2.40502229
35Nephroblastoma (Wilms tumor) (HP:0002667)2.40336835
36Febrile seizures (HP:0002373)2.39357935
37Hypobetalipoproteinemia (HP:0003563)2.36001431
38Preauricular pit (HP:0004467)2.35938154
39Periauricular skin pits (HP:0100277)2.35938154
40Short nail (HP:0001799)2.34834622
41Spinal rigidity (HP:0003306)2.34323371
42Congenital, generalized hypertrichosis (HP:0004540)2.33507258
43Focal seizures (HP:0007359)2.33073190
44Wormian bones (HP:0002645)2.30678159
45Wide anterior fontanel (HP:0000260)2.30246561
46Shallow orbits (HP:0000586)2.29101540
47Focal segmental glomerulosclerosis (HP:0000097)2.27750772
48Partial duplication of the phalanx of hand (HP:0009999)2.25879520
49Aplasia of the musculature (HP:0100854)2.25336057
50Atonic seizures (HP:0010819)2.24925320
51Abnormality of the nasolacrimal system (HP:0000614)2.24846868
52Abnormal delivery (HP:0001787)2.23911398
53Nasolacrimal duct obstruction (HP:0000579)2.23505861
54Abnormality of placental membranes (HP:0011409)2.22754811
55Amniotic constriction ring (HP:0009775)2.22754811
56Increased connective tissue (HP:0009025)2.22402131
57Abnormality of glutamine family amino acid metabolism (HP:0010902)2.21570907
58Right ventricular cardiomyopathy (HP:0011663)2.20944668
59Generalized hypotonia (HP:0001290)2.20254109
60Anomalous pulmonary venous return (HP:0010772)2.18719046
61Blue sclerae (HP:0000592)2.17755285
62Osteolytic defects of the hand bones (HP:0009699)2.16256155
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.16256155
64Abnormality of the lacrimal duct (HP:0011481)2.15245533
65Broad metatarsal (HP:0001783)2.14995491
66Spondylolisthesis (HP:0003302)2.13198565
67Abnormality of carpal bone ossification (HP:0006257)2.12866534
68Atrophic scars (HP:0001075)2.11116119
69Intrahepatic cholestasis (HP:0001406)2.10371467
70Abnormality of monocarboxylic acid metabolism (HP:0010996)2.09853291
71Increased variability in muscle fiber diameter (HP:0003557)2.09364594
72Delayed gross motor development (HP:0002194)2.07868796
73Preaxial foot polydactyly (HP:0001841)2.07021338
74Cervical subluxation (HP:0003308)2.06249560
75Abnormality of the pulmonary veins (HP:0011718)2.03895436
76Mesomelia (HP:0003027)2.03562492
77Focal motor seizures (HP:0011153)2.02918588
78Limited hip movement (HP:0008800)2.01955672
79Hypolipoproteinemia (HP:0010981)2.01336719
80Conjugated hyperbilirubinemia (HP:0002908)2.00874913
81Narrow nasal bridge (HP:0000446)2.00316009
82Amyotrophic lateral sclerosis (HP:0007354)1.98979125
83Cutaneous finger syndactyly (HP:0010554)1.98628630
84Increased corneal curvature (HP:0100692)1.97415542
85Keratoconus (HP:0000563)1.97415542
86Xanthomatosis (HP:0000991)1.96999336
87Complement deficiency (HP:0004431)1.95783652
88Sensory axonal neuropathy (HP:0003390)1.95503701
89Partial duplication of thumb phalanx (HP:0009944)1.94724324
90Ankle contracture (HP:0006466)1.93331595
91Abnormality of the distal phalanx of the thumb (HP:0009617)1.91804993
92Shawl scrotum (HP:0000049)1.91393885
93Ovoid vertebral bodies (HP:0003300)1.90628598
94Limb-girdle muscle atrophy (HP:0003797)1.90443863
95Aplasia/Hypoplasia of the sternum (HP:0006714)1.89711445
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88487929
97Abnormality of the acetabulum (HP:0003170)1.88147023
98Short 5th finger (HP:0009237)1.87787161
99Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.86010608
100Wrist flexion contracture (HP:0001239)1.85584610
101Neoplasm of the heart (HP:0100544)1.84993119
102Glomerulosclerosis (HP:0000096)1.84776462
103Abnormality of complement system (HP:0005339)1.82978464
104Coxa vara (HP:0002812)1.82677970
105Short humerus (HP:0005792)1.82508563
106Bowel diverticulosis (HP:0005222)1.82483089
107Fused cervical vertebrae (HP:0002949)1.82253491
108Alopecia of scalp (HP:0002293)1.79174035
109Vertebral compression fractures (HP:0002953)1.79159950
110Tibial bowing (HP:0002982)1.74861804
111Morphological abnormality of the middle ear (HP:0008609)1.74804646
112Horizontal nystagmus (HP:0000666)1.73723421
113Hypoalphalipoproteinemia (HP:0003233)1.72801612
114Round ear (HP:0100830)1.71627094
115Bronchomalacia (HP:0002780)1.71374004
116Skin pits (HP:0100276)1.70719587
117Exotropia (HP:0000577)1.70416959
118Nemaline bodies (HP:0003798)1.70271293
119Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.70227674
120Prominent supraorbital ridges (HP:0000336)1.69866348
121Short hallux (HP:0010109)1.69546022
122Peritonitis (HP:0002586)1.69507680
123Fat malabsorption (HP:0002630)1.69419003
124Abnormality of aromatic amino acid family metabolism (HP:0004338)1.69132246
125Aplasia/hypoplasia of the humerus (HP:0006507)1.68829023
126Open mouth (HP:0000194)1.68755720
127Hemiparesis (HP:0001269)1.68578261
128Dialeptic seizures (HP:0011146)1.68405720
129Abnormal ossification of hand bones (HP:0005921)1.67992252
130Bladder diverticulum (HP:0000015)1.67767428
131Broad toe (HP:0001837)1.67642481
132Failure to thrive in infancy (HP:0001531)1.66522788
133Preauricular skin tag (HP:0000384)1.66373779
134Infantile muscular hypotonia (HP:0008947)1.66312112
135Genu recurvatum (HP:0002816)1.66026747
136Concave nail (HP:0001598)1.65490344
137Neoplasm of striated muscle (HP:0009728)1.65459740
138Drooling (HP:0002307)1.65292871
139Excessive salivation (HP:0003781)1.65292871
140Rectal fistula (HP:0100590)1.64603168
141Rectovaginal fistula (HP:0000143)1.64603168
142Ulnar bowing (HP:0003031)1.64412160
143Upper limb muscle weakness (HP:0003484)1.64101381
144Mitral valve prolapse (HP:0001634)1.63918812
145Cutaneous syndactyly (HP:0012725)1.63403924
146Myokymia (HP:0002411)1.63247624
147Abnormality of the labia minora (HP:0012880)1.63099173
148Mild short stature (HP:0003502)1.62687180
149Skin nodule (HP:0200036)1.61629380
150Biconcave vertebral bodies (HP:0004586)1.61113044
151Multiple enchondromatosis (HP:0005701)1.60818570
152Large earlobe (HP:0009748)1.60392299
153Hypoventilation (HP:0002791)1.60223907
154Abnormal hand bone ossification (HP:0010660)1.59646348
155Broad thumb (HP:0011304)1.58706041
156Facial cleft (HP:0002006)1.58622028
157Hyperextensible skin (HP:0000974)1.58311131
158Absent frontal sinuses (HP:0002688)1.58305182
159Coronal craniosynostosis (HP:0004440)1.57957254
160Difficulty running (HP:0009046)1.57697061
161Lymphangioma (HP:0100764)1.57608586
162Abnormality of the Achilles tendon (HP:0005109)1.57162481
163Overgrowth (HP:0001548)1.57116561
164Arthropathy (HP:0003040)1.57000876
165Osteoarthritis (HP:0002758)1.56987675
166Trismus (HP:0000211)1.56349899
167Abnormality of skeletal muscle fiber size (HP:0012084)1.56165964
168Aplasia of the phalanges of the hand (HP:0009802)1.55637589
169Aplasia involving bones of the extremities (HP:0009825)1.55637589
170Aplasia involving bones of the upper limbs (HP:0009823)1.55637589
171Hip contracture (HP:0003273)1.55077032
172Absent speech (HP:0001344)1.53810582
173Small epiphyses (HP:0010585)1.53730200
174Fragile skin (HP:0001030)1.53601936
175Omphalocele (HP:0001539)1.52697785
176Breech presentation (HP:0001623)1.52433453
177Aortic regurgitation (HP:0001659)1.51841717
178Hypoplasia of the capital femoral epiphysis (HP:0003090)1.51422275
179Protruding ear (HP:0000411)1.51130154
180Glomerulonephritis (HP:0000099)1.50723640
181Slender build (HP:0001533)1.50302977
182Hypoplastic ischia (HP:0003175)1.49411724

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK54.89026639
2MST1R4.72795958
3CDK124.38378258
4EPHA24.11472770
5MET3.45841373
6GRK62.61581216
7TYRO32.61060569
8CASK2.56124326
9LATS22.42535622
10NTRK12.40880796
11LIMK12.36217007
12EPHA42.28113815
13NTRK32.23820201
14MARK12.20188294
15DDR22.09534993
16ADRBK21.95706212
17MUSK1.91963578
18MAP3K91.86243548
19NTRK21.85071598
20MAPK71.81643043
21GRK71.81526778
22ERN11.79022289
23PDGFRA1.74966985
24MAP2K41.74886468
25GRK11.70627102
26MST41.70512486
27WNK11.69895973
28MAP3K41.68539193
29MOS1.67166708
30EPHA31.53638719
31EPHB21.51140406
32STK391.46982060
33ADRBK11.46077329
34FGFR41.42567514
35TGFBR21.42501803
36CAMK41.40122001
37WNK41.36773750
38PLK21.31653499
39PAK21.30445073
40MINK11.29566656
41FRK1.29555888
42KSR11.28331036
43TESK11.21126513
44MAPKAPK31.20730044
45PAK61.20257177
46SIK21.20242463
47AKT31.16436696
48STK38L1.16225226
49TRPM71.13617941
50MAP2K71.13516225
51TTN1.13309130
52MATK1.13186041
53MARK21.11871442
54NEK11.10280990
55PAK31.10227482
56IRAK31.09775306
57SIK31.05556990
58TSSK61.05045549
59DMPK1.04241559
60MAP3K120.93477976
61FER0.91051596
62CSF1R0.90638033
63ILK0.90355124
64ABL20.88461857
65TRIB30.87546459
66FGFR20.86631109
67PRKCG0.86297915
68DAPK20.84346686
69MAPK130.84080353
70NEK90.83459004
71BMPR1B0.83164321
72PTK20.82459098
73PAK40.81910460
74CDK180.80693929
75STK30.79597250
76ERBB40.76773880
77CDK150.75379949
78CDK50.74905739
79NEK20.72067025
80LATS10.71763331
81DYRK20.71346820
82ACVR1B0.71239857
83NME10.70953238
84FGFR30.69491321
85CDK140.69451127
86PRKG20.68985255
87MAPK150.67824311
88LMTK20.67472698
89MELK0.66581379
90VRK20.65005472
91PTK2B0.64996605
92CDK11A0.64765461
93CAMK2D0.64758839
94MAPK120.64680230
95BCR0.64055008
96PHKG10.62037736
97PHKG20.62037736
98BRSK20.61928682
99TNIK0.61223470
100TTK0.60785946
101DYRK1A0.60503654
102GSK3A0.59407896
103CAMK2G0.58848966
104CAMK2A0.55505430
105MAP3K30.55190086
106ROCK20.54651065
107PBK0.54067320
108FLT30.53964525
109PIK3CG0.53357564
110TGFBR10.53085954
111MAP3K70.50488288
112MAP3K20.49961589
113PTK60.48390383
114BMX0.47848280
115ERBB20.47481092
116EIF2AK10.46340894
117UHMK10.45520700
118WEE10.45318742
119FGFR10.45137802
120ERBB30.45116664
121PRKCE0.43905671
122STK240.43754620
123PRKCI0.41954961
124ROCK10.41205363
125EPHB10.41197193
126SIK10.41176620
127AKT20.40563957
128CDC42BPA0.39758710
129PLK30.39422603
130PRPF4B0.38891130
131HIPK20.38624029
132RET0.38008578
133KSR20.37563507
134RIPK10.37473102
135TRIM280.37459939
136MAPK100.37449286
137MAP2K10.36956209
138OXSR10.36655590
139CSNK1E0.35983157
140CDK70.35776161
141PIK3CA0.34901200
142PDGFRB0.34164724
143DAPK30.34130119
144PRKACA0.32728861
145CAMK2B0.32678107
146CHEK20.32505025
147SRC0.32431162
148MYLK0.31871364
149MAPKAPK50.31792050
150TAOK10.31440587
151CDK80.31433640
152PNCK0.31353390
153INSR0.30356282
154WNK30.30138610
155STK380.29016841

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.49206494
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90148377
3Complement and coagulation cascades_Homo sapiens_hsa046102.69433658
4Nicotine addiction_Homo sapiens_hsa050332.59676241
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31497405
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.22170426
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.18756093
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14854780
9Histidine metabolism_Homo sapiens_hsa003402.01558113
10GABAergic synapse_Homo sapiens_hsa047272.00098051
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00070148
12Chemical carcinogenesis_Homo sapiens_hsa052041.94607392
13Axon guidance_Homo sapiens_hsa043601.93520423
14Synaptic vesicle cycle_Homo sapiens_hsa047211.90892904
15Taste transduction_Homo sapiens_hsa047421.86591654
16Retinol metabolism_Homo sapiens_hsa008301.85462430
17Sulfur metabolism_Homo sapiens_hsa009201.84830824
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.78963698
19Glutamatergic synapse_Homo sapiens_hsa047241.76448271
20Hedgehog signaling pathway_Homo sapiens_hsa043401.76419048
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.73678766
22Fat digestion and absorption_Homo sapiens_hsa049751.71858633
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.67785056
24Basal cell carcinoma_Homo sapiens_hsa052171.65487851
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61515056
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60083540
27Serotonergic synapse_Homo sapiens_hsa047261.59045306
28Long-term potentiation_Homo sapiens_hsa047201.58529435
29Circadian entrainment_Homo sapiens_hsa047131.53279811
30Amphetamine addiction_Homo sapiens_hsa050311.49137531
31Long-term depression_Homo sapiens_hsa047301.48701629
32Vitamin B6 metabolism_Homo sapiens_hsa007501.47907358
33Dilated cardiomyopathy_Homo sapiens_hsa054141.47709360
34Dopaminergic synapse_Homo sapiens_hsa047281.47570845
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47420096
36Starch and sucrose metabolism_Homo sapiens_hsa005001.47419101
37Bile secretion_Homo sapiens_hsa049761.46628773
38Caffeine metabolism_Homo sapiens_hsa002321.46379727
39ECM-receptor interaction_Homo sapiens_hsa045121.45916861
40Cardiac muscle contraction_Homo sapiens_hsa042601.44091601
41Salivary secretion_Homo sapiens_hsa049701.41923335
42Selenocompound metabolism_Homo sapiens_hsa004501.40816778
43Hippo signaling pathway_Homo sapiens_hsa043901.39603928
44Gap junction_Homo sapiens_hsa045401.39276753
45Arginine biosynthesis_Homo sapiens_hsa002201.38243965
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37702524
47Arginine and proline metabolism_Homo sapiens_hsa003301.36568808
48Renin secretion_Homo sapiens_hsa049241.36509578
49Phenylalanine metabolism_Homo sapiens_hsa003601.33572938
50GnRH signaling pathway_Homo sapiens_hsa049121.32903334
51Fatty acid degradation_Homo sapiens_hsa000711.32318541
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.32277943
53Oxytocin signaling pathway_Homo sapiens_hsa049211.31754374
54Cocaine addiction_Homo sapiens_hsa050301.31722114
55Morphine addiction_Homo sapiens_hsa050321.29456406
56Melanogenesis_Homo sapiens_hsa049161.29246766
57Tryptophan metabolism_Homo sapiens_hsa003801.29193513
58Calcium signaling pathway_Homo sapiens_hsa040201.28967055
59Wnt signaling pathway_Homo sapiens_hsa043101.25203889
60PPAR signaling pathway_Homo sapiens_hsa033201.24924266
61Olfactory transduction_Homo sapiens_hsa047401.23495111
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22573822
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22339176
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21110177
65Mineral absorption_Homo sapiens_hsa049781.20728061
66Glutathione metabolism_Homo sapiens_hsa004801.20411735
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20112582
68Vitamin digestion and absorption_Homo sapiens_hsa049771.18904954
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18563146
70Gastric acid secretion_Homo sapiens_hsa049711.15041181
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14322632
72Protein digestion and absorption_Homo sapiens_hsa049741.12909480
73Rap1 signaling pathway_Homo sapiens_hsa040151.11063783
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10908341
75Phospholipase D signaling pathway_Homo sapiens_hsa040721.10060593
76Tyrosine metabolism_Homo sapiens_hsa003501.09594047
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07907310
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07218367
79Drug metabolism - other enzymes_Homo sapiens_hsa009831.06725534
80Cholinergic synapse_Homo sapiens_hsa047251.06489645
81Focal adhesion_Homo sapiens_hsa045101.06140919
82Fructose and mannose metabolism_Homo sapiens_hsa000511.05876374
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02063984
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01434368
85Glioma_Homo sapiens_hsa052141.00973472
86cAMP signaling pathway_Homo sapiens_hsa040241.00283285
87ErbB signaling pathway_Homo sapiens_hsa040120.99008276
88Collecting duct acid secretion_Homo sapiens_hsa049660.97575635
89Choline metabolism in cancer_Homo sapiens_hsa052310.97341274
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97054214
91Pyruvate metabolism_Homo sapiens_hsa006200.96922775
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.95331325
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95227176
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95174079
95Steroid biosynthesis_Homo sapiens_hsa001000.93840008
96Insulin secretion_Homo sapiens_hsa049110.93331349
97Melanoma_Homo sapiens_hsa052180.92797250
98mTOR signaling pathway_Homo sapiens_hsa041500.91746427
99Proteoglycans in cancer_Homo sapiens_hsa052050.91480764
100Butanoate metabolism_Homo sapiens_hsa006500.90015087
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89795033
102Protein export_Homo sapiens_hsa030600.89775429
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89202465
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88170532
105Oxidative phosphorylation_Homo sapiens_hsa001900.88099031
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87626059
107Ras signaling pathway_Homo sapiens_hsa040140.87614711
108Estrogen signaling pathway_Homo sapiens_hsa049150.86749593
109Alzheimers disease_Homo sapiens_hsa050100.86418964
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86154727
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85143075
112Tight junction_Homo sapiens_hsa045300.83978687
113beta-Alanine metabolism_Homo sapiens_hsa004100.83699340
114Arachidonic acid metabolism_Homo sapiens_hsa005900.80606551
115Linoleic acid metabolism_Homo sapiens_hsa005910.79152803
116Pathways in cancer_Homo sapiens_hsa052000.78590506
117Nitrogen metabolism_Homo sapiens_hsa009100.78466162
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78302707
119Adherens junction_Homo sapiens_hsa045200.78109343
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77835635
121Ovarian steroidogenesis_Homo sapiens_hsa049130.77047432
122Vibrio cholerae infection_Homo sapiens_hsa051100.76544153
123Parkinsons disease_Homo sapiens_hsa050120.76523354
124One carbon pool by folate_Homo sapiens_hsa006700.75860066
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75098180
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74524511
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74392451
128Thyroid cancer_Homo sapiens_hsa052160.72364272
129Dorso-ventral axis formation_Homo sapiens_hsa043200.71692614
130Thyroid hormone synthesis_Homo sapiens_hsa049180.71624096
131Sulfur relay system_Homo sapiens_hsa041220.71274918
132TGF-beta signaling pathway_Homo sapiens_hsa043500.71128610
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70787820
134Bladder cancer_Homo sapiens_hsa052190.70135396
135MAPK signaling pathway_Homo sapiens_hsa040100.69173761
136N-Glycan biosynthesis_Homo sapiens_hsa005100.68760279
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67116824
138Peroxisome_Homo sapiens_hsa041460.66563246
139Endometrial cancer_Homo sapiens_hsa052130.63521884
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62859813
141MicroRNAs in cancer_Homo sapiens_hsa052060.61624100
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61563108
143Folate biosynthesis_Homo sapiens_hsa007900.61128710
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60993119
145Fatty acid biosynthesis_Homo sapiens_hsa000610.60038212
146Amoebiasis_Homo sapiens_hsa051460.59370014
147Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59130178
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.59000277
149Colorectal cancer_Homo sapiens_hsa052100.58248370
150Galactose metabolism_Homo sapiens_hsa000520.58123805
151African trypanosomiasis_Homo sapiens_hsa051430.57939826
152Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57300216
153Renal cell carcinoma_Homo sapiens_hsa052110.57220136
154Glycerolipid metabolism_Homo sapiens_hsa005610.57106731
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.56879283
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56244866
157ABC transporters_Homo sapiens_hsa020100.55500536
158Small cell lung cancer_Homo sapiens_hsa052220.55249150
159Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54721483
160Fatty acid metabolism_Homo sapiens_hsa012120.54598895
161Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54286537
162Huntingtons disease_Homo sapiens_hsa050160.53365832
163Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52173651
164VEGF signaling pathway_Homo sapiens_hsa043700.51657655
165Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49982526
166Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49922722
167Glycosaminoglycan degradation_Homo sapiens_hsa005310.49215889
168Neurotrophin signaling pathway_Homo sapiens_hsa047220.49158711
169Sphingolipid metabolism_Homo sapiens_hsa006000.49113364
170AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48932174
171Non-small cell lung cancer_Homo sapiens_hsa052230.48537141
172Renin-angiotensin system_Homo sapiens_hsa046140.48327993
173Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46533703
174Proteasome_Homo sapiens_hsa030500.46410533

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