SPCS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)8.44100814
2COPI coating of Golgi vesicle (GO:0048205)8.44100814
3* signal peptide processing (GO:0006465)6.33619677
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.27331427
5protein retention in ER lumen (GO:0006621)5.50506762
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.39737199
7DNA deamination (GO:0045006)5.37224284
8protein maturation by protein folding (GO:0022417)5.20207763
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.70531964
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.68048068
11* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.55495052
12sequestering of metal ion (GO:0051238)4.46891952
13* cotranslational protein targeting to membrane (GO:0006613)4.46727595
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.44770429
15ATP synthesis coupled proton transport (GO:0015986)4.44770429
16* protein targeting to ER (GO:0045047)4.43729070
17COPII vesicle coating (GO:0048208)4.40638989
18ribosomal small subunit assembly (GO:0000028)4.36945128
19chaperone-mediated protein transport (GO:0072321)4.28632016
20* protein localization to endoplasmic reticulum (GO:0070972)4.27044383
21respiratory electron transport chain (GO:0022904)4.26949759
22protein complex biogenesis (GO:0070271)4.19848714
23* establishment of protein localization to endoplasmic reticulum (GO:0072599)4.19107177
24electron transport chain (GO:0022900)4.18962166
25anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.07697912
26GDP-mannose metabolic process (GO:0019673)4.06055773
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.05494350
28mitochondrial respiratory chain complex assembly (GO:0033108)3.99022277
29protein neddylation (GO:0045116)3.88920169
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.82556279
31NADH dehydrogenase complex assembly (GO:0010257)3.82556279
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82556279
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.80247080
34ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.77857046
35CENP-A containing nucleosome assembly (GO:0034080)3.75579601
36signal transduction involved in DNA damage checkpoint (GO:0072422)3.73633579
37signal transduction involved in DNA integrity checkpoint (GO:0072401)3.73633579
38protein N-linked glycosylation via asparagine (GO:0018279)3.73353789
39signal transduction involved in cell cycle checkpoint (GO:0072395)3.71704678
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.71080384
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.71080384
42chromatin remodeling at centromere (GO:0031055)3.69666501
43exocrine pancreas development (GO:0031017)3.67709927
44peptidyl-asparagine modification (GO:0018196)3.67349069
45positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.61095793
46DNA double-strand break processing (GO:0000729)3.58961824
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.56786204
48positive regulation of nuclease activity (GO:0032075)3.54255547
49termination of RNA polymerase III transcription (GO:0006386)3.53357476
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.53357476
51activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.52693181
52regulation of mitochondrial translation (GO:0070129)3.44606352
53positive regulation of ligase activity (GO:0051351)3.44595531
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.42974670
55pteridine-containing compound biosynthetic process (GO:0042559)3.42484083
56protein N-linked glycosylation (GO:0006487)3.42481668
57water-soluble vitamin biosynthetic process (GO:0042364)3.41657060
58antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.41080190
59rRNA modification (GO:0000154)3.39623660
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37676672
61regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.35183642
62regulation of nuclease activity (GO:0032069)3.34065988
63secondary metabolite biosynthetic process (GO:0044550)3.33131512
64melanin biosynthetic process (GO:0042438)3.33031823
65histone exchange (GO:0043486)3.29931498
66regulation of cellular amine metabolic process (GO:0033238)3.27733123
67antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.27675034
68pseudouridine synthesis (GO:0001522)3.24535668
69platelet dense granule organization (GO:0060155)3.23780210
70endocrine pancreas development (GO:0031018)3.23383158
71regulation of ubiquitin-protein transferase activity (GO:0051438)3.23300611
72endoplasmic reticulum unfolded protein response (GO:0030968)3.19287887
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17201700
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17201700
75proteasome assembly (GO:0043248)3.15752704
76cellular response to topologically incorrect protein (GO:0035967)3.15641246
77cellular response to unfolded protein (GO:0034620)3.15588520
78dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.15403394
79establishment of integrated proviral latency (GO:0075713)3.14758055
80telomere maintenance via semi-conservative replication (GO:0032201)3.13137055
81protein targeting to mitochondrion (GO:0006626)3.12332321
82peptide hormone processing (GO:0016486)3.12316405
83ER overload response (GO:0006983)3.11647796
84DNA damage response, detection of DNA damage (GO:0042769)3.11491971
85regulation of ligase activity (GO:0051340)3.11033809
86antigen processing and presentation of endogenous antigen (GO:0019883)3.10495393
87DNA catabolic process, exonucleolytic (GO:0000738)3.08907551
88glandular epithelial cell differentiation (GO:0002067)3.08054379
89DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.06954818
90ER to Golgi vesicle-mediated transport (GO:0006888)3.04628630
91* translation (GO:0006412)3.04439449
92protein deneddylation (GO:0000338)3.04039173
93negative regulation of DNA-dependent DNA replication (GO:2000104)3.02963588
94maturation of 5.8S rRNA (GO:0000460)3.01163727
95regulation of type B pancreatic cell apoptotic process (GO:2000674)3.00762365
96folic acid-containing compound biosynthetic process (GO:0009396)3.00116082
97cell redox homeostasis (GO:0045454)3.00045418
98viral transcription (GO:0019083)2.99118433
99protein localization to mitochondrion (GO:0070585)2.97798587
100L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97542021
101vesicle coating (GO:0006901)2.95614684
102protein-cofactor linkage (GO:0018065)2.95156440
103translational termination (GO:0006415)2.93608511
104establishment of protein localization to mitochondrion (GO:0072655)2.92925070
105DNA ligation (GO:0006266)2.92079621
106ER-nucleus signaling pathway (GO:0006984)2.88716158
107cullin deneddylation (GO:0010388)2.88502220
108* protein targeting to membrane (GO:0006612)2.87743329
109oxidative phosphorylation (GO:0006119)2.87546378
110purine nucleobase biosynthetic process (GO:0009113)2.86837005
111DNA strand elongation involved in DNA replication (GO:0006271)2.86707692
112spliceosomal snRNP assembly (GO:0000387)2.85970824
113positive regulation of cell cycle arrest (GO:0071158)2.85830541
114kinetochore assembly (GO:0051382)2.84043136
115melanin metabolic process (GO:0006582)2.83945722
116inner mitochondrial membrane organization (GO:0007007)2.83279468
117DNA replication checkpoint (GO:0000076)2.83025405
118negative regulation of glycoprotein biosynthetic process (GO:0010561)2.82043435
119negative regulation of protein ubiquitination (GO:0031397)2.80725479
120histone mRNA metabolic process (GO:0008334)2.80721278
121replication fork processing (GO:0031297)2.80329697
122DNA strand elongation (GO:0022616)2.79899522
123regulation of mitotic spindle checkpoint (GO:1903504)2.79596368
124regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79596368
125protein K6-linked ubiquitination (GO:0085020)2.78881866
126translational elongation (GO:0006414)2.78449983
127hydrogen ion transmembrane transport (GO:1902600)2.78300011
128negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77091728
129kinetochore organization (GO:0051383)2.76705436
130telomere maintenance via recombination (GO:0000722)2.76521622
131UDP-N-acetylglucosamine metabolic process (GO:0006047)2.70895271
132lactate metabolic process (GO:0006089)2.70886681
1332-deoxyribonucleotide biosynthetic process (GO:0009265)2.70312729
134deoxyribose phosphate biosynthetic process (GO:0046385)2.70312729
135intracellular protein transmembrane import (GO:0044743)2.69302920
136DNA replication-independent nucleosome assembly (GO:0006336)2.68580011
137DNA replication-independent nucleosome organization (GO:0034724)2.68580011
138rRNA methylation (GO:0031167)2.68510169
139mannosylation (GO:0097502)2.67569994
140G1/S transition of mitotic cell cycle (GO:0000082)2.67446238
141cell cycle G1/S phase transition (GO:0044843)2.67446238
142establishment of viral latency (GO:0019043)2.66358256
143aldehyde catabolic process (GO:0046185)2.66220723
144response to endoplasmic reticulum stress (GO:0034976)2.64791264
145fatty acid elongation (GO:0030497)2.63610746
146respiratory chain complex IV assembly (GO:0008535)2.63263091
147protein K11-linked ubiquitination (GO:0070979)2.62959480
148proline biosynthetic process (GO:0006561)2.61191573
149nucleotide-sugar metabolic process (GO:0009225)2.58881209
150purine-containing compound salvage (GO:0043101)2.56123672
151GMP metabolic process (GO:0046037)2.54119388
152regulation of cellular amino acid metabolic process (GO:0006521)2.53051766
153positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.50872149
154protein peptidyl-prolyl isomerization (GO:0000413)2.49817174
155negative regulation of ligase activity (GO:0051352)2.49505987
156negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49505987
157chaperone-mediated protein folding (GO:0061077)2.48493047
158regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47910991
159DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.46251742
160response to unfolded protein (GO:0006986)2.45636393
161viral life cycle (GO:0019058)2.45413397
162response to topologically incorrect protein (GO:0035966)2.44423691
163ribosomal small subunit biogenesis (GO:0042274)2.43949509
164formation of translation preinitiation complex (GO:0001731)2.43827753
165peptidyl-histidine modification (GO:0018202)2.43041402
166intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.42716106
167signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42716106
168signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.41723762
169signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.41723762
170signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.41723762
171translational initiation (GO:0006413)2.41289768
172maturation of SSU-rRNA (GO:0030490)2.41046659
173positive regulation of insulin secretion (GO:0032024)2.40705536
174Arp2/3 complex-mediated actin nucleation (GO:0034314)2.40574170
175iron-sulfur cluster assembly (GO:0016226)2.38661120
176metallo-sulfur cluster assembly (GO:0031163)2.38661120
177mitochondrial calcium ion transport (GO:0006851)2.38392789
178cytochrome complex assembly (GO:0017004)2.37940543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05743294
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.98821638
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.90411447
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.63325029
5E2F7_22180533_ChIP-Seq_HELA_Human3.56791465
6* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.54140964
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44886955
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37319954
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.18216543
10* EST1_17652178_ChIP-ChIP_JURKAT_Human3.17318917
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.84429688
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.84256790
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70067086
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.65994873
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.65022566
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.56110884
17VDR_23849224_ChIP-Seq_CD4+_Human2.54847674
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51710775
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44844138
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.30880729
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28671836
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.25306724
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.24287377
24FOXP3_21729870_ChIP-Seq_TREG_Human2.21218383
25DCP1A_22483619_ChIP-Seq_HELA_Human2.21152392
26ERG_20887958_ChIP-Seq_HPC-7_Mouse2.17865650
27* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.13720215
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13646125
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12482611
30GABP_19822575_ChIP-Seq_HepG2_Human2.10859867
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05767920
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05553161
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04977620
34SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.04484211
35HOXB4_20404135_ChIP-ChIP_EML_Mouse2.03920706
36VDR_22108803_ChIP-Seq_LS180_Human2.02398357
37SRF_21415370_ChIP-Seq_HL-1_Mouse2.01971144
38XRN2_22483619_ChIP-Seq_HELA_Human1.98445786
39ELK1_19687146_ChIP-ChIP_HELA_Human1.93266901
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93225139
41ZNF274_21170338_ChIP-Seq_K562_Hela1.89744621
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88063122
43DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.84751684
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79345877
45* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79289731
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78760710
47* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75355640
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74982122
49EWS_26573619_Chip-Seq_HEK293_Human1.69643041
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69327161
51FUS_26573619_Chip-Seq_HEK293_Human1.68431177
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66101335
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65448081
54SPI1_23547873_ChIP-Seq_NB4_Human1.62629825
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.58529899
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58306609
57MYC_18940864_ChIP-ChIP_HL60_Human1.57943642
58IGF1R_20145208_ChIP-Seq_DFB_Human1.57750977
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.56820024
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.56414022
61TTF2_22483619_ChIP-Seq_HELA_Human1.56274592
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55673661
63* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52819446
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52252469
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52167877
66GATA1_22025678_ChIP-Seq_K562_Human1.51606844
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47966111
68CIITA_25753668_ChIP-Seq_RAJI_Human1.47430242
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47207630
70TFEB_21752829_ChIP-Seq_HELA_Human1.45162127
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.43100204
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43042272
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.37964832
74MYC_22102868_ChIP-Seq_BL_Human1.35665714
75TAF15_26573619_Chip-Seq_HEK293_Human1.35578930
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33887721
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31528891
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.30513754
79KDM5A_27292631_Chip-Seq_BREAST_Human1.30223475
80P300_19829295_ChIP-Seq_ESCs_Human1.27941340
81AR_21909140_ChIP-Seq_LNCAP_Human1.27608511
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25526145
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24395603
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23506712
85MYB_26560356_Chip-Seq_TH2_Human1.23093520
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22168503
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22146683
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20699421
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.18225797
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15457771
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14051842
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13550532
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12782794
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11278797
95FOXM1_23109430_ChIP-Seq_U2OS_Human1.11153815
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11076927
97* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10444486
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.10318232
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10165805
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09468691
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08959255
102* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08733292
103* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07951375
104* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07413171
105VDR_21846776_ChIP-Seq_THP-1_Human1.05149452
106IRF8_21731497_ChIP-ChIP_J774_Mouse1.04585711
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04006492
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03599432
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02556820
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02046447
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01726399
112POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01392801
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00793791
114SCL_19346495_ChIP-Seq_HPC-7_Human1.00374773
115NFE2_27457419_Chip-Seq_LIVER_Mouse0.99777816
116GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99638757
117EZH2_27294783_Chip-Seq_NPCs_Mouse0.99051504
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98947064
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98680052
120MYB_26560356_Chip-Seq_TH1_Human0.97925019
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97542983
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97463334
123POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97385546
124HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97321832
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95704229
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95483151
127SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95032286
128HTT_18923047_ChIP-ChIP_STHdh_Human0.93837314
129NANOG_16153702_ChIP-ChIP_HESCs_Human0.93393116
130RUNX1_22412390_ChIP-Seq_EML_Mouse0.91124740
131PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90571458
132TP53_22573176_ChIP-Seq_HFKS_Human0.90430259
133SOX2_19829295_ChIP-Seq_ESCs_Human0.90395039
134NANOG_19829295_ChIP-Seq_ESCs_Human0.90395039
135VDR_24763502_ChIP-Seq_THP-1_Human0.89699638
136TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89143488
137ER_23166858_ChIP-Seq_MCF-7_Human0.88884390
138FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88684804
139FOXA1_25329375_ChIP-Seq_VCAP_Human0.88684804
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88340047
141STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87389648
142GBX2_23144817_ChIP-Seq_PC3_Human0.87084302
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86117981
144NANOG_18555785_ChIP-Seq_MESCs_Mouse0.83781446
145AR_20517297_ChIP-Seq_VCAP_Human0.83275743
146FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83016888
147CBP_20019798_ChIP-Seq_JUKART_Human0.81975053
148IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81975053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.66227191
2MP0003693_abnormal_embryo_hatching3.17046587
3MP0003183_abnormal_peptide_metabolism3.15777929
4MP0002877_abnormal_melanocyte_morpholog3.10616938
5MP0005220_abnormal_exocrine_pancreas3.05034820
6MP0002693_abnormal_pancreas_physiology2.96980267
7MP0002102_abnormal_ear_morphology2.85331830
8MP0005171_absent_coat_pigmentation2.66011577
9MP0001944_abnormal_pancreas_morphology2.62075172
10MP0006054_spinal_hemorrhage2.58962257
11MP0003724_increased_susceptibility_to2.49572692
12MP0005671_abnormal_response_to2.38864822
13MP0001529_abnormal_vocalization2.34800956
14MP0001835_abnormal_antigen_presentation2.32509299
15MP0001986_abnormal_taste_sensitivity2.31450328
16MP0003718_maternal_effect2.18803594
17MP0003763_abnormal_thymus_physiology2.14842207
18MP0005379_endocrine/exocrine_gland_phen2.10359241
19MP0001984_abnormal_olfaction2.04190130
20MP0004043_abnormal_pH_regulation1.96552159
21MP0003195_calcinosis1.93142878
22MP0005058_abnormal_lysosome_morphology1.91938521
23MP0005253_abnormal_eye_physiology1.87733733
24MP0004957_abnormal_blastocyst_morpholog1.87492357
25MP0002736_abnormal_nociception_after1.87131760
26MP0004147_increased_porphyrin_level1.84540199
27MP0000678_abnormal_parathyroid_gland1.82405245
28MP0009333_abnormal_splenocyte_physiolog1.82376061
29MP0000013_abnormal_adipose_tissue1.77812466
30MP0009785_altered_susceptibility_to1.74270034
31MP0003880_abnormal_central_pattern1.69620126
32MP0002090_abnormal_vision1.68202410
33MP0003866_abnormal_defecation1.65666825
34MP0000490_abnormal_crypts_of1.65611637
35MP0008877_abnormal_DNA_methylation1.65518062
36MP0003186_abnormal_redox_activity1.65410368
37MP0003111_abnormal_nucleus_morphology1.65168641
38MP0010386_abnormal_urinary_bladder1.64662903
39MP0009697_abnormal_copulation1.63640687
40MP0005000_abnormal_immune_tolerance1.61978367
41MP0008007_abnormal_cellular_replicative1.61501869
42MP0003011_delayed_dark_adaptation1.61374366
43MP0003436_decreased_susceptibility_to1.55772604
44MP0003786_premature_aging1.54322070
45MP0008058_abnormal_DNA_repair1.53134230
46MP0005551_abnormal_eye_electrophysiolog1.50061418
47MP0000685_abnormal_immune_system1.49270549
48MP0005025_abnormal_response_to1.49078261
49MP0002909_abnormal_adrenal_gland1.48200890
50MP0004264_abnormal_extraembryonic_tissu1.44954666
51MP0001324_abnormal_eye_pigmentation1.43783058
52MP0005075_abnormal_melanosome_morpholog1.42972969
53MP0002148_abnormal_hypersensitivity_rea1.41524037
54MP0000015_abnormal_ear_pigmentation1.41102999
55MP0002420_abnormal_adaptive_immunity1.40185907
56MP0006035_abnormal_mitochondrial_morpho1.38930526
57MP0002396_abnormal_hematopoietic_system1.38926081
58MP0001819_abnormal_immune_cell1.37660108
59MP0000613_abnormal_salivary_gland1.37214418
60MP0002723_abnormal_immune_serum1.36564244
61MP0001905_abnormal_dopamine_level1.35375599
62MP0009379_abnormal_foot_pigmentation1.34858750
63MP0002166_altered_tumor_susceptibility1.34264094
64MP0002419_abnormal_innate_immunity1.33907759
65MP0001845_abnormal_inflammatory_respons1.33282205
66MP0002933_joint_inflammation1.32953914
67MP0000465_gastrointestinal_hemorrhage1.30901049
68MP0003890_abnormal_embryonic-extraembry1.30712622
69MP0002398_abnormal_bone_marrow1.29758115
70MP0003283_abnormal_digestive_organ1.29628624
71MP0000569_abnormal_digit_pigmentation1.29579441
72MP0008789_abnormal_olfactory_epithelium1.29154739
73MP0001800_abnormal_humoral_immune1.27288868
74MP0002837_dystrophic_cardiac_calcinosis1.26237282
75MP0002452_abnormal_antigen_presenting1.26223849
76MP0005636_abnormal_mineral_homeostasis1.25094606
77MP0005408_hypopigmentation1.24121414
78MP0002405_respiratory_system_inflammati1.23462717
79MP0001764_abnormal_homeostasis1.23453546
80MP0005310_abnormal_salivary_gland1.23294730
81MP0009643_abnormal_urine_homeostasis1.23222779
82MP0009046_muscle_twitch1.21288087
83MP0002638_abnormal_pupillary_reflex1.20946934
84MP0000716_abnormal_immune_system1.20814346
85MP0001790_abnormal_immune_system1.19942290
86MP0005387_immune_system_phenotype1.19942290
87MP0003121_genomic_imprinting1.19346249
88MP0000647_abnormal_sebaceous_gland1.18326405
89MP0010155_abnormal_intestine_physiology1.18221211
90MP0005084_abnormal_gallbladder_morpholo1.16928759
91MP0002078_abnormal_glucose_homeostasis1.16879633
92MP0003300_gastrointestinal_ulcer1.15219454
93MP0001968_abnormal_touch/_nociception1.13900610
94MP0004782_abnormal_surfactant_physiolog1.13408761
95MP0003077_abnormal_cell_cycle1.13313101
96MP0002429_abnormal_blood_cell1.12122222
97MP0000689_abnormal_spleen_morphology1.11073955
98MP0001666_abnormal_nutrient_absorption1.10740552
99MP0001293_anophthalmia1.10532011
100MP0000371_diluted_coat_color1.10093499
101MP0010094_abnormal_chromosome_stability1.09660787
102MP0000681_abnormal_thyroid_gland1.09566465
103MP0002722_abnormal_immune_system1.08921925
104MP0003172_abnormal_lysosome_physiology1.08634271
105MP0003567_abnormal_fetal_cardiomyocyte1.08616808
106MP0001533_abnormal_skeleton_physiology1.07448339
107MP0008872_abnormal_physiological_respon1.06468181
108MP0005174_abnormal_tail_pigmentation1.05961828
109MP0003868_abnormal_feces_composition1.05863194
110MP0001485_abnormal_pinna_reflex1.05647869
111MP0000372_irregular_coat_pigmentation1.05536565
112MP0002095_abnormal_skin_pigmentation1.05431778
113MP0002163_abnormal_gland_morphology1.04713772
114MP0006292_abnormal_olfactory_placode1.04252285
115MP0000858_altered_metastatic_potential1.03798308
116MP0008469_abnormal_protein_level1.03407038
117MP0008875_abnormal_xenobiotic_pharmacok1.03275340
118MP0000703_abnormal_thymus_morphology1.03191430
119MP0001873_stomach_inflammation1.02934612
120MP0006036_abnormal_mitochondrial_physio1.02087344
121MP0002928_abnormal_bile_duct1.00834112
122MP0005464_abnormal_platelet_physiology1.00159412
123MP0004142_abnormal_muscle_tone0.98288736
124MP0003806_abnormal_nucleotide_metabolis0.98143900
125MP0006072_abnormal_retinal_apoptosis0.96849903
126MP0008932_abnormal_embryonic_tissue0.96411568
127MP0004215_abnormal_myocardial_fiber0.90918350
128MP0000427_abnormal_hair_cycle0.90679976
129MP0001853_heart_inflammation0.90246370
130MP0003795_abnormal_bone_structure0.89904136
131MP0003959_abnormal_lean_body0.89878425
132MP0002751_abnormal_autonomic_nervous0.89854698
133MP0002019_abnormal_tumor_incidence0.89767507
134MP0001929_abnormal_gametogenesis0.89423416
135MP0002210_abnormal_sex_determination0.89204022
136MP0003943_abnormal_hepatobiliary_system0.88076120
137MP0002938_white_spotting0.87963069
138MP0002006_tumorigenesis0.87484714
139MP0002277_abnormal_respiratory_mucosa0.87268265
140MP0000358_abnormal_cell_content/0.87137446
141MP0005365_abnormal_bile_salt0.87097217
142MP0004808_abnormal_hematopoietic_stem0.85837925
143MP0002132_abnormal_respiratory_system0.84162333
144MP0002272_abnormal_nervous_system0.82646748
145MP0001919_abnormal_reproductive_system0.82554169
146MP0005389_reproductive_system_phenotype0.82490747
147MP0002234_abnormal_pharynx_morphology0.81566315
148MP0005332_abnormal_amino_acid0.81319186
149MP0004133_heterotaxia0.80460756
150MP0009745_abnormal_behavioral_response0.80193824
151MP0005391_vision/eye_phenotype0.78901909
152MP0002160_abnormal_reproductive_system0.78434275
153MP0000653_abnormal_sex_gland0.78079082
154MP0002282_abnormal_trachea_morphology0.77950000
155MP0005394_taste/olfaction_phenotype0.77263666
156MP0005499_abnormal_olfactory_system0.77263666
157MP0005645_abnormal_hypothalamus_physiol0.76902530
158MP0000516_abnormal_urinary_system0.73915280
159MP0005367_renal/urinary_system_phenotyp0.73915280
160MP0000631_abnormal_neuroendocrine_gland0.73529207
161MP0004885_abnormal_endolymph0.71846924
162MP0005395_other_phenotype0.71352963
163MP0005410_abnormal_fertilization0.70794336
164MP0005187_abnormal_penis_morphology0.69510863
165MP0001145_abnormal_male_reproductive0.69235836
166MP0001186_pigmentation_phenotype0.68304630
167MP0006276_abnormal_autonomic_nervous0.67104175
168MP0001119_abnormal_female_reproductive0.64773852
169MP0003698_abnormal_male_reproductive0.63078301
170MP0002075_abnormal_coat/hair_pigmentati0.62953164
171MP0002233_abnormal_nose_morphology0.62436102
172MP0003123_paternal_imprinting0.60919684
173MP0008995_early_reproductive_senescence0.60762697
174MP0005195_abnormal_posterior_eye0.60323877
175MP0004924_abnormal_behavior0.57325248

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)4.96512819
2Abnormal protein glycosylation (HP:0012346)4.56521539
3Abnormal glycosylation (HP:0012345)4.56521539
4Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.56521539
5Abnormal protein N-linked glycosylation (HP:0012347)4.56521539
6Progressive macrocephaly (HP:0004481)4.43916902
7Reduced antithrombin III activity (HP:0001976)4.08491853
8Increased hepatocellular lipid droplets (HP:0006565)4.00342547
9Hypoglycemic seizures (HP:0002173)3.86198561
10Hypoglycemic coma (HP:0001325)3.85269270
11Hyperinsulinemic hypoglycemia (HP:0000825)3.73095082
12Vacuolated lymphocytes (HP:0001922)3.59726893
13Symptomatic seizures (HP:0011145)3.49712485
14Aplastic anemia (HP:0001915)3.44328472
15Cerebral edema (HP:0002181)3.35939466
16Generalized aminoaciduria (HP:0002909)3.35760209
17Thrombocytosis (HP:0001894)3.28259171
18Renal Fanconi syndrome (HP:0001994)3.25547629
19Methylmalonic acidemia (HP:0002912)3.00451016
20IgM deficiency (HP:0002850)2.99562560
21Late onset (HP:0003584)2.82856889
22Poor head control (HP:0002421)2.82652333
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.82284806
24Dysostosis multiplex (HP:0000943)2.79432233
25Abnormality of T cell physiology (HP:0011840)2.76612410
26Hepatic necrosis (HP:0002605)2.75517322
27Methylmalonic aciduria (HP:0012120)2.75238415
28Respiratory failure (HP:0002878)2.69367327
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.65093906
30Lactic acidosis (HP:0003128)2.64829965
31Abnormality of methionine metabolism (HP:0010901)2.64533871
32Increased serum pyruvate (HP:0003542)2.62947418
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61453782
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61453782
35Abnormality of the labia minora (HP:0012880)2.61376040
36Hypothermia (HP:0002045)2.61328473
37Degeneration of anterior horn cells (HP:0002398)2.61023363
38Abnormality of the anterior horn cell (HP:0006802)2.61023363
393-Methylglutaconic aciduria (HP:0003535)2.60960481
40Mucopolysacchariduria (HP:0008155)2.59829445
41Urinary glycosaminoglycan excretion (HP:0003541)2.59829445
42Abnormality of glycolysis (HP:0004366)2.58967233
43Increased intramyocellular lipid droplets (HP:0012240)2.58378719
44Abnormality of endocrine pancreas physiology (HP:0012093)2.57982359
45Abnormality of the pancreatic islet cells (HP:0006476)2.57982359
46Congenital, generalized hypertrichosis (HP:0004540)2.54706255
47Abnormality of the intrinsic pathway (HP:0010989)2.53664930
48Abnormal number of erythroid precursors (HP:0012131)2.51104133
4911 pairs of ribs (HP:0000878)2.49346173
50Leukodystrophy (HP:0002415)2.48584704
51Medial flaring of the eyebrow (HP:0010747)2.45090329
52Exercise intolerance (HP:0003546)2.44604163
53Patchy hypopigmentation of hair (HP:0011365)2.43167379
54Pancreatic cysts (HP:0001737)2.42974750
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42554084
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.42058646
57True hermaphroditism (HP:0010459)2.40694496
58Lethargy (HP:0001254)2.40132651
59Progressive neurologic deterioration (HP:0002344)2.39632047
60Exertional dyspnea (HP:0002875)2.39266380
61Pancreatic fibrosis (HP:0100732)2.38005432
62Beaking of vertebral bodies (HP:0004568)2.37457251
63Elevated erythrocyte sedimentation rate (HP:0003565)2.35512718
64Optic disc pallor (HP:0000543)2.35489852
65Recurrent bronchitis (HP:0002837)2.35432481
66Abnormality of cells of the erythroid lineage (HP:0012130)2.33331571
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32352651
68Hyperglycinemia (HP:0002154)2.32348169
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.28081479
70Abnormality of T cells (HP:0002843)2.28010812
71Hepatocellular necrosis (HP:0001404)2.27093423
72B lymphocytopenia (HP:0010976)2.25192891
73Abnormality of B cell number (HP:0010975)2.25192891
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24963011
75Abnormality of polysaccharide metabolism (HP:0011012)2.24963011
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24963011
77Hypoplasia of the thymus (HP:0000778)2.22759390
78Pancreatic islet-cell hyperplasia (HP:0004510)2.20493117
79Molar tooth sign on MRI (HP:0002419)2.19989455
80Abnormality of midbrain morphology (HP:0002418)2.19989455
81Abnormality of calcium-phosphate metabolism (HP:0100530)2.15665476
82Congenital primary aphakia (HP:0007707)2.15602152
83Meckel diverticulum (HP:0002245)2.15441473
84Gait imbalance (HP:0002141)2.11221541
85Abnormal pancreas size (HP:0012094)2.11124060
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10824637
87Abnormality of serum amino acid levels (HP:0003112)2.08985436
88Chronic otitis media (HP:0000389)2.08350772
89Aplasia/Hypoplasia of the macula (HP:0008059)2.06610984
90Hypoplasia of the fovea (HP:0007750)2.06270314
91Aplasia/Hypoplasia of the fovea (HP:0008060)2.06270314
92Increased muscle lipid content (HP:0009058)2.06116985
93Megaloblastic anemia (HP:0001889)2.05386131
94Abnormality of the ileum (HP:0001549)2.04794859
95Bronchitis (HP:0012387)2.04471632
96Short tibia (HP:0005736)2.04167360
97Abnormal lung lobation (HP:0002101)2.03449532
98Aplasia/Hypoplasia of the uvula (HP:0010293)2.03275372
99Median cleft lip (HP:0000161)2.03259026
100Prominent metopic ridge (HP:0005487)2.02496154
101Abnormality of renal resorption (HP:0011038)2.01792247
102CNS demyelination (HP:0007305)2.01321508
103Mitochondrial inheritance (HP:0001427)1.99921927
104Abnormality of the vitamin B12 metabolism (HP:0004341)1.99732178
105Microretrognathia (HP:0000308)1.99369848
106Abnormality of vitamin B metabolism (HP:0004340)1.98990538
107Neoplasm of the adrenal gland (HP:0100631)1.98660061
108Thoracolumbar scoliosis (HP:0002944)1.98642960
109Insulin-resistant diabetes mellitus (HP:0000831)1.98370743
110Respiratory difficulties (HP:0002880)1.98359786
111Abnormality of chromosome stability (HP:0003220)1.98233800
112Nephrogenic diabetes insipidus (HP:0009806)1.98128821
113Intestinal atresia (HP:0011100)1.95603669
114Abnormality of the fovea (HP:0000493)1.94572919
115Eczematoid dermatitis (HP:0000976)1.93227528
116Large for gestational age (HP:0001520)1.93080594
117T lymphocytopenia (HP:0005403)1.91825982
118Irregular vertebral endplates (HP:0003301)1.89717162
119Severe visual impairment (HP:0001141)1.89686552
120Abnormal mitochondria in muscle tissue (HP:0008316)1.89614912
121Aplasia/Hypoplasia affecting the retina (HP:0008061)1.89601259
122Congenital stationary night blindness (HP:0007642)1.87865722
123Abnormal rod and cone electroretinograms (HP:0008323)1.87782290
124Recurrent abscess formation (HP:0002722)1.87274981
125Hyperglycemia (HP:0003074)1.86960442
126Renal cortical cysts (HP:0000803)1.86491056
127Reticulocytopenia (HP:0001896)1.85703699
128Myositis (HP:0100614)1.85195523
129White forelock (HP:0002211)1.84354231
130Abnormality of serine family amino acid metabolism (HP:0010894)1.84310778
131Abnormality of glycine metabolism (HP:0010895)1.84310778
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.83794437
133Acute necrotizing encephalopathy (HP:0006965)1.83769908
134Neutropenia (HP:0001875)1.83350947
135X-linked dominant inheritance (HP:0001423)1.80325602
136Bifid tongue (HP:0010297)1.80235050
137Genital tract atresia (HP:0001827)1.79752564
138Abnormality of T cell number (HP:0011839)1.78930847
139Microvesicular hepatic steatosis (HP:0001414)1.78531142
140Abnormality of the preputium (HP:0100587)1.78087916
141Supernumerary spleens (HP:0009799)1.77169721
142Decreased circulating renin level (HP:0003351)1.76898134
143Meningitis (HP:0001287)1.76492921
144Abnormality of urine glucose concentration (HP:0011016)1.76127171
145Glycosuria (HP:0003076)1.76127171
146Hypoplasia of the pons (HP:0012110)1.76093122
147Abnormal delayed hypersensitivity skin test (HP:0002963)1.74610031
148Insulin resistance (HP:0000855)1.74235733
149Increased CSF lactate (HP:0002490)1.73985860
150Hyperphosphaturia (HP:0003109)1.72516088
151Adrenal hypoplasia (HP:0000835)1.72461049
152Vaginal atresia (HP:0000148)1.72256540
153Cerebral hypomyelination (HP:0006808)1.72116743
154Limb hypertonia (HP:0002509)1.71354306
155Colon cancer (HP:0003003)1.70837568
156Petechiae (HP:0000967)1.70300981
157Aplasia/hypoplasia of the uterus (HP:0008684)1.69437488
158Sparse eyelashes (HP:0000653)1.69268185
159Dicarboxylic aciduria (HP:0003215)1.68419051
160Ketoacidosis (HP:0001993)1.64644627
161Abnormality of the pons (HP:0007361)1.64074972
162IgG deficiency (HP:0004315)1.63988792
163Pancytopenia (HP:0001876)1.63543649
164Increased neuronal autofluorescent lipopigment (HP:0002074)1.63192167
165Increased serum lactate (HP:0002151)1.62772512
166Conjugated hyperbilirubinemia (HP:0002908)1.61960929
167Recurrent viral infections (HP:0004429)1.61439735
168Lipid accumulation in hepatocytes (HP:0006561)1.60206058
169Progressive muscle weakness (HP:0003323)1.59540533
170Acute encephalopathy (HP:0006846)1.59267590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK3.83923924
2STK163.51961881
3EIF2AK33.25964051
4VRK22.96709115
5TRIM282.75168463
6EIF2AK12.74604027
7INSRR2.71370988
8ERN12.70158164
9FLT32.56034195
10TAOK32.51114889
11NEK12.47947172
12NME22.40672495
13MAPK152.32069855
14IRAK42.26266889
15BUB12.23854322
16WNK32.20344522
17IRAK32.15796393
18PLK32.14083762
19TEC2.07950753
20TESK22.05168292
21BCKDK1.99447054
22VRK11.82510368
23KDR1.81516116
24MAP4K21.80851694
25PLK21.77881115
26MAP4K11.76701939
27BCR1.73738892
28PDK21.72643799
29SCYL21.72281387
30ERBB31.69890932
31HIPK21.65161732
32TESK11.64949759
33TXK1.64019732
34ZAP701.63852881
35BTK1.45454990
36TTK1.44071360
37DYRK31.40844714
38PIM21.40039672
39ACVR1B1.39374131
40ZAK1.37887818
41BRSK21.36154375
42IRAK11.29245899
43RPS6KA41.25800866
44BLK1.24199063
45CSNK1G31.23856317
46NLK1.23547073
47JAK31.18772125
48TBK11.18745894
49CSNK1G21.15639680
50CSNK1G11.15073380
51WEE11.13273310
52KIT1.10233982
53PNCK1.10199936
54CDK81.09687575
55FRK1.04808754
56TLK11.04797823
57SRPK11.03908362
58GRK10.98207954
59ITK0.97928551
60IKBKE0.95731446
61DYRK20.95071899
62STK38L0.94148149
63MST40.92941863
64MAPK130.90572588
65NEK90.89959814
66MAPKAPK30.89068341
67CAMKK20.85791564
68PIK3CG0.85623788
69TGFBR10.83763122
70CASK0.83515749
71CSNK1A1L0.82687281
72TYK20.81833716
73LYN0.81308430
74TSSK60.79819545
75OXSR10.78450836
76IRAK20.78317728
77LIMK10.75621843
78BMPR1B0.74823013
79PBK0.74158077
80PRKCG0.73161962
81SYK0.73020377
82SIK30.72364171
83PLK40.70877586
84MKNK10.69960849
85YES10.69783398
86MKNK20.68727690
87PINK10.68485909
88EPHA30.67895906
89NME10.67468419
90MAP3K120.67234551
91PRKG20.66319942
92STK390.66290207
93TAF10.65901685
94MINK10.64966190
95MAP2K70.64092251
96LCK0.63610204
97AURKB0.60826378
98BRAF0.60711590
99PRKCE0.60145239
100PAK30.57272147
101DYRK1B0.55869639
102MAPKAPK50.55784196
103DAPK10.54604329
104MAP3K110.52115440
105STK30.51868328
106ATR0.51197747
107RPS6KB20.50262966
108CDC70.50199205
109MAP3K140.49182657
110ERBB40.48291578
111CSNK2A10.48250082
112CDK70.47473320
113CCNB10.47250361
114FER0.46658618
115ATM0.44790257
116CHEK20.44548286
117BRSK10.43981059
118MAP3K40.42959350
119TNIK0.42516534
120CSNK1A10.42431874
121CSK0.42172599
122GRK50.42135806
123CSF1R0.42033894
124FGFR20.41535494
125MAP3K10.40447522
126PAK40.40223588
127EIF2AK20.40145358
128AURKA0.39637097
129MARK30.38637319
130EPHA40.38424384
131PRKCI0.38389118
132CAMK2A0.38090935
133CDK30.37839510
134PLK10.37575026
135CSNK2A20.37491372
136ADRBK20.37202604
137RPS6KA50.36553849
138IKBKB0.36016624
139CHUK0.35916079
140LRRK20.34780902
141FES0.34527780
142CLK10.34287571
143MAP2K20.33545609
144PIM10.31789470
145MST1R0.30137514
146FGFR10.28769174
147NUAK10.28508637
148ILK0.27630546
149MAPKAPK20.27618101
150ADRBK10.27345521
151MYLK0.26923132
152CAMK2D0.26687069
153ABL20.26318414
154CDK140.26057017
155CDK180.25740922

Predicted pathways (KEGG)

RankGene SetZ-score
1* Protein export_Homo sapiens_hsa030606.48176599
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.87576881
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.08065699
4DNA replication_Homo sapiens_hsa030302.86210054
5Proteasome_Homo sapiens_hsa030502.81868737
6Ribosome_Homo sapiens_hsa030102.76261615
7N-Glycan biosynthesis_Homo sapiens_hsa005102.59196850
8Folate biosynthesis_Homo sapiens_hsa007902.24529008
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18544324
10Mismatch repair_Homo sapiens_hsa034302.16735908
11Other glycan degradation_Homo sapiens_hsa005112.07825276
12Sulfur metabolism_Homo sapiens_hsa009201.99754534
13Propanoate metabolism_Homo sapiens_hsa006401.86891124
14Base excision repair_Homo sapiens_hsa034101.86032299
15RNA polymerase_Homo sapiens_hsa030201.82346400
16Pyrimidine metabolism_Homo sapiens_hsa002401.75747010
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.73872764
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72228093
19Antigen processing and presentation_Homo sapiens_hsa046121.72138793
20Steroid biosynthesis_Homo sapiens_hsa001001.68967847
21Homologous recombination_Homo sapiens_hsa034401.68862257
22Spliceosome_Homo sapiens_hsa030401.67085042
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65453785
24Selenocompound metabolism_Homo sapiens_hsa004501.63912195
25Nucleotide excision repair_Homo sapiens_hsa034201.59520442
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57502426
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52291461
28Non-homologous end-joining_Homo sapiens_hsa034501.50284201
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.48188852
30Butanoate metabolism_Homo sapiens_hsa006501.41431989
31Vibrio cholerae infection_Homo sapiens_hsa051101.38712586
32One carbon pool by folate_Homo sapiens_hsa006701.33800953
33Primary immunodeficiency_Homo sapiens_hsa053401.30272615
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28815113
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.28241352
36Legionellosis_Homo sapiens_hsa051341.26318338
37Pyruvate metabolism_Homo sapiens_hsa006201.22397220
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.21975281
39Lysosome_Homo sapiens_hsa041421.20708970
40Sulfur relay system_Homo sapiens_hsa041221.18919863
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16027856
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14544680
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13524861
44Galactose metabolism_Homo sapiens_hsa000521.12344423
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07900042
46RNA degradation_Homo sapiens_hsa030181.06583180
47Collecting duct acid secretion_Homo sapiens_hsa049661.06203617
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04409196
49RNA transport_Homo sapiens_hsa030131.03200604
50Type I diabetes mellitus_Homo sapiens_hsa049401.02025910
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00485139
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99414357
53Basal transcription factors_Homo sapiens_hsa030220.98168416
54Vitamin B6 metabolism_Homo sapiens_hsa007500.97192833
55Cardiac muscle contraction_Homo sapiens_hsa042600.96788902
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92847633
57Fatty acid metabolism_Homo sapiens_hsa012120.90972548
58Purine metabolism_Homo sapiens_hsa002300.90407377
59Cell cycle_Homo sapiens_hsa041100.86194752
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.85312304
61Oxidative phosphorylation_Homo sapiens_hsa001900.84862988
62Tryptophan metabolism_Homo sapiens_hsa003800.80584397
63Carbon metabolism_Homo sapiens_hsa012000.76611192
64beta-Alanine metabolism_Homo sapiens_hsa004100.75024823
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74674122
66Nitrogen metabolism_Homo sapiens_hsa009100.74121834
67Phototransduction_Homo sapiens_hsa047440.72030642
68Fatty acid degradation_Homo sapiens_hsa000710.71977223
69Parkinsons disease_Homo sapiens_hsa050120.71877166
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.70516086
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.70258530
72Measles_Homo sapiens_hsa051620.69785215
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69749460
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68794935
75Oocyte meiosis_Homo sapiens_hsa041140.68523586
76Hematopoietic cell lineage_Homo sapiens_hsa046400.68086728
77Fanconi anemia pathway_Homo sapiens_hsa034600.67704701
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67181991
79Regulation of autophagy_Homo sapiens_hsa041400.67112483
80Tyrosine metabolism_Homo sapiens_hsa003500.65817002
81Thyroid cancer_Homo sapiens_hsa052160.65677297
82Herpes simplex infection_Homo sapiens_hsa051680.65252516
83Chemical carcinogenesis_Homo sapiens_hsa052040.63653541
84Caffeine metabolism_Homo sapiens_hsa002320.62113790
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61555773
86Biosynthesis of amino acids_Homo sapiens_hsa012300.61328659
87Pentose phosphate pathway_Homo sapiens_hsa000300.60777163
88Sphingolipid metabolism_Homo sapiens_hsa006000.58663801
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57443093
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57288128
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57167777
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56953847
93Epstein-Barr virus infection_Homo sapiens_hsa051690.55940111
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55078342
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53194213
96p53 signaling pathway_Homo sapiens_hsa041150.53026543
97Leishmaniasis_Homo sapiens_hsa051400.52797479
98Asthma_Homo sapiens_hsa053100.51780868
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.50921863
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48615962
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47002559
102Glutathione metabolism_Homo sapiens_hsa004800.45143148
103Renin-angiotensin system_Homo sapiens_hsa046140.45131797
104Metabolic pathways_Homo sapiens_hsa011000.45115964
105Phagosome_Homo sapiens_hsa041450.44424990
106Huntingtons disease_Homo sapiens_hsa050160.42981676
107Arginine and proline metabolism_Homo sapiens_hsa003300.42006272
108Arachidonic acid metabolism_Homo sapiens_hsa005900.41202840
109Fructose and mannose metabolism_Homo sapiens_hsa000510.40325080
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38916931
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38496532
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37686290
113Pertussis_Homo sapiens_hsa051330.35849570
114Starch and sucrose metabolism_Homo sapiens_hsa005000.35070731
115Vitamin digestion and absorption_Homo sapiens_hsa049770.34634706
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.33575223
117Alzheimers disease_Homo sapiens_hsa050100.33150060
118Retinol metabolism_Homo sapiens_hsa008300.32633666
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32487093
120Fatty acid elongation_Homo sapiens_hsa000620.32079328
121mRNA surveillance pathway_Homo sapiens_hsa030150.30909997
122Viral carcinogenesis_Homo sapiens_hsa052030.30224450
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29164863
124Histidine metabolism_Homo sapiens_hsa003400.29027488
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28947254
126Mineral absorption_Homo sapiens_hsa049780.27709588
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27709167
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27681668
129Allograft rejection_Homo sapiens_hsa053300.27141049
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.26119939
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26036961
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.25565082
133Shigellosis_Homo sapiens_hsa051310.25558909
134Insulin secretion_Homo sapiens_hsa049110.25482985
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24483776
136Pancreatic secretion_Homo sapiens_hsa049720.24055611
137Ether lipid metabolism_Homo sapiens_hsa005650.23040567
138Apoptosis_Homo sapiens_hsa042100.22464753
139Hepatitis B_Homo sapiens_hsa051610.21895870
140Nicotine addiction_Homo sapiens_hsa050330.21587583
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20618148
142Peroxisome_Homo sapiens_hsa041460.20512993
143Systemic lupus erythematosus_Homo sapiens_hsa053220.20474446
144Linoleic acid metabolism_Homo sapiens_hsa005910.20347101
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18570101
146Influenza A_Homo sapiens_hsa051640.18517993

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