SPCS2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.46248079
2positive regulation of action potential (GO:0045760)5.79020796
3water-soluble vitamin biosynthetic process (GO:0042364)5.41382628
4tachykinin receptor signaling pathway (GO:0007217)5.40481634
5negative regulation of heart rate (GO:0010459)5.16015499
6signal peptide processing (GO:0006465)4.69508434
7regulation of action potential (GO:0098900)4.59268882
8GTP biosynthetic process (GO:0006183)4.43691052
9regulation of immunoglobulin secretion (GO:0051023)4.20320032
10negative regulation of synaptic transmission, GABAergic (GO:0032229)4.14386472
11regulation of dopamine secretion (GO:0014059)4.12411438
12positive regulation of synaptic transmission, GABAergic (GO:0032230)4.11773971
13ATP synthesis coupled proton transport (GO:0015986)3.99552802
14energy coupled proton transport, down electrochemical gradient (GO:0015985)3.99552802
15cytidine metabolic process (GO:0046087)3.93083464
16cytidine catabolic process (GO:0006216)3.93083464
17cytidine deamination (GO:0009972)3.93083464
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.89152748
19protein deneddylation (GO:0000338)3.86602012
20positive regulation of steroid hormone secretion (GO:2000833)3.81067543
21positive regulation of digestive system process (GO:0060456)3.72974401
22chaperone-mediated protein transport (GO:0072321)3.70804879
23protein neddylation (GO:0045116)3.68633410
24UTP biosynthetic process (GO:0006228)3.62675233
25regulation of isotype switching to IgG isotypes (GO:0048302)3.53300871
26regulation of chronic inflammatory response (GO:0002676)3.48481278
27regulation of cytokine production involved in inflammatory response (GO:1900015)3.47283917
28pyrimidine ribonucleoside catabolic process (GO:0046133)3.46985891
29behavioral response to nicotine (GO:0035095)3.45202434
30phosphatidylinositol acyl-chain remodeling (GO:0036149)3.39266411
31protein complex biogenesis (GO:0070271)3.34293279
32ubiquinone biosynthetic process (GO:0006744)3.33349634
33growth hormone secretion (GO:0030252)3.33128127
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32584444
35positive regulation of growth hormone secretion (GO:0060124)3.22346536
36fucose catabolic process (GO:0019317)3.21927158
37L-fucose metabolic process (GO:0042354)3.21927158
38L-fucose catabolic process (GO:0042355)3.21927158
39platelet dense granule organization (GO:0060155)3.19956872
40UTP metabolic process (GO:0046051)3.19917974
41piRNA metabolic process (GO:0034587)3.17513774
42cytokine biosynthetic process (GO:0042089)3.17368257
43cullin deneddylation (GO:0010388)3.14963083
44pseudouridine synthesis (GO:0001522)3.13967524
45aggressive behavior (GO:0002118)3.10116801
46phenol-containing compound catabolic process (GO:0019336)3.08690386
47purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.07301588
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05827903
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05488345
50negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.04340966
51negative regulation of T-helper cell differentiation (GO:0045623)3.04340966
52ubiquinone metabolic process (GO:0006743)3.02834757
53purine nucleoside triphosphate biosynthetic process (GO:0009145)2.99259988
54regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.93895876
55electron transport chain (GO:0022900)2.92219701
56respiratory electron transport chain (GO:0022904)2.90312625
57regulation of interleukin-6 biosynthetic process (GO:0045408)2.88183309
58serotonin receptor signaling pathway (GO:0007210)2.86276740
59mitochondrial respiratory chain complex assembly (GO:0033108)2.84360057
60dopamine transport (GO:0015872)2.81367808
61establishment of protein localization to mitochondrial membrane (GO:0090151)2.80089701
62T-helper cell differentiation (GO:0042093)2.78435811
63CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.78435811
64DNA methylation involved in gamete generation (GO:0043046)2.77669824
65termination of RNA polymerase III transcription (GO:0006386)2.76737311
66transcription elongation from RNA polymerase III promoter (GO:0006385)2.76737311
67phosphatidylserine acyl-chain remodeling (GO:0036150)2.76228432
68protein-cofactor linkage (GO:0018065)2.75627756
69quinone biosynthetic process (GO:1901663)2.74768099
70positive regulation of granulocyte differentiation (GO:0030854)2.74760963
71protein prenylation (GO:0018342)2.74269635
72prenylation (GO:0097354)2.74269635
73negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.73641558
74regulation of mitochondrial translation (GO:0070129)2.72007207
75positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.70949304
76NADH dehydrogenase complex assembly (GO:0010257)2.69342725
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69342725
78mitochondrial respiratory chain complex I assembly (GO:0032981)2.69342725
79detection of light stimulus involved in sensory perception (GO:0050962)2.68505145
80detection of light stimulus involved in visual perception (GO:0050908)2.68505145
81nucleoside diphosphate phosphorylation (GO:0006165)2.67220003
82CTP biosynthetic process (GO:0006241)2.66565844
83CTP metabolic process (GO:0046036)2.66565844
84appendage development (GO:0048736)2.66529777
85limb development (GO:0060173)2.66529777
86ATP biosynthetic process (GO:0006754)2.64231231
87kidney morphogenesis (GO:0060993)2.63195151
88protein K11-linked deubiquitination (GO:0035871)2.58558785
89response to pheromone (GO:0019236)2.57804445
90epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57567743
91cytokine metabolic process (GO:0042107)2.57391748
92guanosine-containing compound biosynthetic process (GO:1901070)2.56285812
93maternal behavior (GO:0042711)2.54135111
94phosphatidylcholine acyl-chain remodeling (GO:0036151)2.53526676
95negative regulation of acute inflammatory response (GO:0002674)2.53261897
96alpha-beta T cell differentiation involved in immune response (GO:0002293)2.52674539
97alpha-beta T cell activation involved in immune response (GO:0002287)2.52674539
98T cell differentiation involved in immune response (GO:0002292)2.52674539
99tRNA processing (GO:0008033)2.52305693
100maturation of SSU-rRNA (GO:0030490)2.51802856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FLI1_27457419_Chip-Seq_LIVER_Mouse3.66450594
2ZNF274_21170338_ChIP-Seq_K562_Hela3.50411606
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.40892756
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34248462
5VDR_22108803_ChIP-Seq_LS180_Human3.22363138
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.95720137
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90382976
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.75747936
9GBX2_23144817_ChIP-Seq_PC3_Human2.54417793
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30560887
11IGF1R_20145208_ChIP-Seq_DFB_Human2.23926927
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13032480
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.08888309
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03296259
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01728086
16NOTCH1_21737748_ChIP-Seq_TLL_Human1.93920055
17FUS_26573619_Chip-Seq_HEK293_Human1.91521944
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87639487
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86517887
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85663091
21TP53_22573176_ChIP-Seq_HFKS_Human1.83252197
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79037832
23NFE2_27457419_Chip-Seq_LIVER_Mouse1.78124688
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71180355
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.70723274
26VDR_23849224_ChIP-Seq_CD4+_Human1.68885877
27EWS_26573619_Chip-Seq_HEK293_Human1.67418562
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.65371836
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61664141
30MYC_18940864_ChIP-ChIP_HL60_Human1.61349133
31P300_19829295_ChIP-Seq_ESCs_Human1.60719207
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54487694
33EZH2_27294783_Chip-Seq_NPCs_Mouse1.50518686
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.46015573
35ER_23166858_ChIP-Seq_MCF-7_Human1.45209085
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40897273
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38687684
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38034016
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.36315386
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36315386
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35688848
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35622649
43ELK1_19687146_ChIP-ChIP_HELA_Human1.33988334
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32770172
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31933694
46FOXP3_21729870_ChIP-Seq_TREG_Human1.30327783
47CRX_20693478_ChIP-Seq_RETINA_Mouse1.29268263
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28812432
49MYC_19829295_ChIP-Seq_ESCs_Human1.27978175
50P53_22387025_ChIP-Seq_ESCs_Mouse1.26361954
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24385769
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23757283
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23420566
54SOX2_19829295_ChIP-Seq_ESCs_Human1.22548020
55NANOG_19829295_ChIP-Seq_ESCs_Human1.22548020
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.20236716
57EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19141038
58HTT_18923047_ChIP-ChIP_STHdh_Human1.18719651
59STAT3_18555785_Chip-Seq_ESCs_Mouse1.17330782
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17175058
61P300_18555785_Chip-Seq_ESCs_Mouse1.16811434
62NCOR_22424771_ChIP-Seq_293T_Human1.15927266
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14880706
64RNF2_27304074_Chip-Seq_NSC_Mouse1.13622673
65OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13110969
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12884586
67NANOG_20526341_ChIP-Seq_ESCs_Human1.12663918
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.12160748
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11640708
70STAT3_23295773_ChIP-Seq_U87_Human1.11580254
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09587671
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07992301
73SOX2_18555785_Chip-Seq_ESCs_Mouse1.06574509
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05904146
75TAF15_26573619_Chip-Seq_HEK293_Human1.05735223
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05439950
77TCF4_23295773_ChIP-Seq_U87_Human1.05398415
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03893481
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02787960
80EGR1_19032775_ChIP-ChIP_M12_Human1.02719743
81CTCF_18555785_Chip-Seq_ESCs_Mouse1.01692925
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.01637054
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01282983
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00124496
85CMYC_18555785_Chip-Seq_ESCs_Mouse0.99540523
86OCT4_20526341_ChIP-Seq_ESCs_Human0.99443810
87CBP_20019798_ChIP-Seq_JUKART_Human0.99254328
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99254328
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98302974
90ETV1_20927104_ChIP-Seq_GIST48_Human0.96844663
91TTF2_22483619_ChIP-Seq_HELA_Human0.96821678
92OCT4_18555785_Chip-Seq_ESCs_Mouse0.96808736
93SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96559050
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95730102
95NMYC_18555785_Chip-Seq_ESCs_Mouse0.95594578
96BCAT_22108803_ChIP-Seq_LS180_Human0.95423673
97KLF4_18555785_Chip-Seq_ESCs_Mouse0.95211807
98ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94795042
99RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94044515
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93951564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder4.61739588
2MP0001501_abnormal_sleep_pattern3.54021331
3MP0008875_abnormal_xenobiotic_pharmacok3.42132226
4MP0001348_abnormal_lacrimal_gland3.22907388
5MP0003195_calcinosis3.06128916
6MP0002102_abnormal_ear_morphology3.02279470
7MP0003787_abnormal_imprinting2.91513582
8MP0003283_abnormal_digestive_organ2.58069307
9MP0008872_abnormal_physiological_respon2.41766751
10MP0005551_abnormal_eye_electrophysiolog2.36003983
11MP0008877_abnormal_DNA_methylation2.32967121
12MP0004885_abnormal_endolymph2.25889127
13MP0001986_abnormal_taste_sensitivity2.19656469
14MP0002876_abnormal_thyroid_physiology2.07712332
15MP0003121_genomic_imprinting1.92564061
16MP0002272_abnormal_nervous_system1.76462145
17MP0001968_abnormal_touch/_nociception1.76347762
18MP0001529_abnormal_vocalization1.70809167
19MP0005253_abnormal_eye_physiology1.67313882
20MP0001905_abnormal_dopamine_level1.65764503
21MP0009745_abnormal_behavioral_response1.64506513
22MP0004142_abnormal_muscle_tone1.63036294
23MP0005671_abnormal_response_to1.62224869
24MP0000427_abnormal_hair_cycle1.60213261
25MP0002736_abnormal_nociception_after1.60127285
26MP0005646_abnormal_pituitary_gland1.56938130
27MP0001873_stomach_inflammation1.55576169
28MP0002160_abnormal_reproductive_system1.53593467
29MP0001835_abnormal_antigen_presentation1.49173810
30MP0006035_abnormal_mitochondrial_morpho1.48440089
31MP0003879_abnormal_hair_cell1.47397439
32MP0004924_abnormal_behavior1.42471645
33MP0005386_behavior/neurological_phenoty1.42471645
34MP0001790_abnormal_immune_system1.37484195
35MP0005387_immune_system_phenotype1.37484195
36MP0005171_absent_coat_pigmentation1.36932661
37MP0009785_altered_susceptibility_to1.35900269
38MP0006072_abnormal_retinal_apoptosis1.35830063
39MP0001970_abnormal_pain_threshold1.34294126
40MP0001756_abnormal_urination1.32885329
41MP0000372_irregular_coat_pigmentation1.31964739
42MP0003123_paternal_imprinting1.31829576
43MP0002572_abnormal_emotion/affect_behav1.29690518
44MP0005389_reproductive_system_phenotype1.29621958
45MP0002928_abnormal_bile_duct1.28742094
46MP0000631_abnormal_neuroendocrine_gland1.27334723
47MP0003786_premature_aging1.26812310
48MP0004145_abnormal_muscle_electrophysio1.26768449
49MP0002735_abnormal_chemical_nociception1.25189064
50MP0006036_abnormal_mitochondrial_physio1.23203834
51MP0009046_muscle_twitch1.22816056
52MP0000685_abnormal_immune_system1.20211656
53MP0002693_abnormal_pancreas_physiology1.17899626
54MP0002933_joint_inflammation1.16178062
55MP0002095_abnormal_skin_pigmentation1.15188899
56MP0003122_maternal_imprinting1.12435722
57MP0002557_abnormal_social/conspecific_i1.11720709
58MP0008775_abnormal_heart_ventricle1.10806795
59MP0002148_abnormal_hypersensitivity_rea1.09687320
60MP0001984_abnormal_olfaction1.09616567
61MP0003436_decreased_susceptibility_to0.99591115
62MP0002064_seizures0.99297103
63MP0002733_abnormal_thermal_nociception0.98496105
64MP0001440_abnormal_grooming_behavior0.98026176
65MP0002837_dystrophic_cardiac_calcinosis0.97120556
66MP0001919_abnormal_reproductive_system0.96221848
67MP0005636_abnormal_mineral_homeostasis0.94608756
68MP0003635_abnormal_synaptic_transmissio0.93748185
69MP0001800_abnormal_humoral_immune0.93366661
70MP0003011_delayed_dark_adaptation0.90794735
71MP0001661_extended_life_span0.90179422
72MP0002166_altered_tumor_susceptibility0.89253407
73MP0005187_abnormal_penis_morphology0.88457432
74MP0001765_abnormal_ion_homeostasis0.86926916
75MP0001486_abnormal_startle_reflex0.86746396
76MP0005360_urolithiasis0.86222259
77MP0006292_abnormal_olfactory_placode0.86092542
78MP0004043_abnormal_pH_regulation0.84880607
79MP0003866_abnormal_defecation0.84745578
80MP0002067_abnormal_sensory_capabilities0.84634182
81MP0003718_maternal_effect0.83455841
82MP0004742_abnormal_vestibular_system0.81707064
83MP0002938_white_spotting0.81693944
84MP0002184_abnormal_innervation0.81144756
85MP0010155_abnormal_intestine_physiology0.79390812
86MP0003186_abnormal_redox_activity0.79338824
87MP0000647_abnormal_sebaceous_gland0.78837973
88MP0002229_neurodegeneration0.77635808
89MP0001881_abnormal_mammary_gland0.75294722
90MP0008058_abnormal_DNA_repair0.74783946
91MP0005084_abnormal_gallbladder_morpholo0.72441392
92MP0002063_abnormal_learning/memory/cond0.71265388
93MP0001663_abnormal_digestive_system0.70045931
94MP0005379_endocrine/exocrine_gland_phen0.68679139
95MP0005195_abnormal_posterior_eye0.68298541
96MP0002006_tumorigenesis0.66618681
97MP0009697_abnormal_copulation0.65765252
98MP0003959_abnormal_lean_body0.65576926
99MP0001502_abnormal_circadian_rhythm0.65090032
100MP0004134_abnormal_chest_morphology0.64289233

Predicted human phenotypes

RankGene SetZ-score
1Lipid accumulation in hepatocytes (HP:0006561)5.38957241
2Increased hepatocellular lipid droplets (HP:0006565)5.28599694
3Renal Fanconi syndrome (HP:0001994)4.38307913
4Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.10630761
5Congenital stationary night blindness (HP:0007642)3.84756594
6Abnormality of the renal cortex (HP:0011035)3.64679814
73-Methylglutaconic aciduria (HP:0003535)3.46603941
8Pancreatic cysts (HP:0001737)3.45276944
9Acute necrotizing encephalopathy (HP:0006965)3.32544183
10Mitochondrial inheritance (HP:0001427)3.29434132
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.27168162
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.27168162
13Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.25250148
14Increased CSF lactate (HP:0002490)3.21333843
15Pendular nystagmus (HP:0012043)3.20888459
16Renal cortical cysts (HP:0000803)3.18438241
17Exertional dyspnea (HP:0002875)3.16081798
18Increased intramyocellular lipid droplets (HP:0012240)3.11107097
19Progressive macrocephaly (HP:0004481)3.08477276
20Acute encephalopathy (HP:0006846)2.98032186
21Submucous cleft hard palate (HP:0000176)2.96286430
22Mesomelia (HP:0003027)2.94712281
23Pancreatic fibrosis (HP:0100732)2.90196865
24Increased muscle lipid content (HP:0009058)2.88764376
25Abnormality of urine glucose concentration (HP:0011016)2.85377371
26Glycosuria (HP:0003076)2.85377371
27Optic disc pallor (HP:0000543)2.82709514
28Abnormal mitochondria in muscle tissue (HP:0008316)2.82362755
29Abnormal biliary tract physiology (HP:0012439)2.74795416
30Bile duct proliferation (HP:0001408)2.74795416
31Adrenal hypoplasia (HP:0000835)2.71564999
32Nephronophthisis (HP:0000090)2.69604367
33Congenital, generalized hypertrichosis (HP:0004540)2.67075661
34Abnormality of renal resorption (HP:0011038)2.65284988
35Hypothermia (HP:0002045)2.60086623
36Increased serum lactate (HP:0002151)2.58245950
37Inability to walk (HP:0002540)2.52666834
38Large for gestational age (HP:0001520)2.52599566
39Abolished electroretinogram (ERG) (HP:0000550)2.52484174
40Progressive inability to walk (HP:0002505)2.48945105
41Insulin-resistant diabetes mellitus (HP:0000831)2.48679935
42Tubular atrophy (HP:0000092)2.48132414
43True hermaphroditism (HP:0010459)2.47986971
44Abnormality of the renal medulla (HP:0100957)2.46000732
45Polydipsia (HP:0001959)2.44656415
46Abnormal drinking behavior (HP:0030082)2.44656415
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33767093
48Rib fusion (HP:0000902)2.32890099
49Chorioretinal atrophy (HP:0000533)2.31439744
50Limb dystonia (HP:0002451)2.30784127
51Hyperglycemia (HP:0003074)2.29350737
52Cerebral edema (HP:0002181)2.28926782
53Medial flaring of the eyebrow (HP:0010747)2.27202480
54Respiratory difficulties (HP:0002880)2.26619346
55Lactic acidosis (HP:0003128)2.25219652
56Supernumerary spleens (HP:0009799)2.19897711
57Stomatitis (HP:0010280)2.19082228
58Clumsiness (HP:0002312)2.18444629
59Abnormality of macular pigmentation (HP:0008002)2.15404446
60Hyperglycinuria (HP:0003108)2.15010104
61Abnormality of midbrain morphology (HP:0002418)2.08004219
62Molar tooth sign on MRI (HP:0002419)2.08004219
63Tubulointerstitial fibrosis (HP:0005576)2.07416238
64Ketosis (HP:0001946)2.07380365
65Congenital hepatic fibrosis (HP:0002612)2.05592513
66Abnormal number of erythroid precursors (HP:0012131)2.05582754
67Sclerocornea (HP:0000647)2.04443205
68Ketoacidosis (HP:0001993)2.03640463
69Cheilitis (HP:0100825)2.03242906
70Pancreatic islet-cell hyperplasia (HP:0004510)2.00932618
71Aplasia/Hypoplasia of the fovea (HP:0008060)2.00302966
72Hypoplasia of the fovea (HP:0007750)2.00302966
73Congenital sensorineural hearing impairment (HP:0008527)1.97606676
74Hyperglycinemia (HP:0002154)1.96222562
75Cystic liver disease (HP:0006706)1.96193001
76Limb hypertonia (HP:0002509)1.95182364
77Polyuria (HP:0000103)1.95064007
78Aplasia/Hypoplasia of the spleen (HP:0010451)1.94055860
79Hepatic necrosis (HP:0002605)1.93179016
80Thyroiditis (HP:0100646)1.93095435
81Attenuation of retinal blood vessels (HP:0007843)1.91309852
82Asplenia (HP:0001746)1.90614404
83Broad-based gait (HP:0002136)1.90126823
84Decreased central vision (HP:0007663)1.90009396
85Abnormal ciliary motility (HP:0012262)1.88350129
86Hyperphosphaturia (HP:0003109)1.87455839
87Occipital encephalocele (HP:0002085)1.80986496
88Exercise intolerance (HP:0003546)1.80107160
89Oligodactyly (hands) (HP:0001180)1.79294892
90Abnormality of cells of the erythroid lineage (HP:0012130)1.78878236
91Colon cancer (HP:0003003)1.77921388
92Short nail (HP:0001799)1.77519651
93Abnormality of the labia minora (HP:0012880)1.77119139
94Growth hormone deficiency (HP:0000824)1.76055711
95Abnormal rod and cone electroretinograms (HP:0008323)1.75459150
96Anophthalmia (HP:0000528)1.73759968
97Increased corneal curvature (HP:0100692)1.72980406
98Keratoconus (HP:0000563)1.72980406
99Lethargy (HP:0001254)1.72970966
100Gait imbalance (HP:0002141)1.72751621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.25696497
2MAP4K22.75713273
3TAOK32.50187492
4BCKDK2.49877604
5BMPR1B2.44226025
6PBK2.40800551
7WNK42.36577504
8GRK12.34311457
9ZAK2.28525714
10ADRBK22.27147898
11ACVR1B2.21394848
12MAPK132.18953390
13WNK32.13390006
14PHKG11.96704307
15PHKG21.96704307
16STK38L1.95925236
17VRK21.88384177
18NEK11.80177111
19PLK21.71162398
20PLK41.70313954
21TXK1.62753669
22MAP2K61.58682144
23PIK3CG1.45448307
24CSNK1G21.38959645
25PINK11.35668071
26MAPKAPK51.26199302
27PLK31.23323263
28STK161.16183416
29NME11.08295420
30TSSK61.07881302
31STK241.06982387
32PRKCE1.03976111
33EPHA41.02072836
34MAP3K41.01316066
35TGFBR11.00226022
36CSNK1G30.96371208
37TIE10.95908225
38ERBB30.95253480
39IKBKB0.94720155
40FGFR20.93102289
41MAP2K70.91556349
42MARK10.90496687
43TRIM280.89926558
44PIK3CA0.89786383
45TLK10.88210186
46MKNK20.84201458
47TEC0.84075976
48EIF2AK10.82699815
49NUAK10.81127420
50VRK10.78609425
51INSRR0.77172427
52ITK0.71745381
53ADRBK10.71741792
54PRKCG0.71595614
55DAPK20.71470163
56PRKCH0.71358396
57MAPKAPK30.71281315
58CAMK2A0.70893973
59MST40.70397819
60CLK10.69180684
61IKBKE0.65859584
62CSNK1G10.65314082
63CAMKK20.64407260
64STK390.64331376
65OXSR10.63688014
66NTRK30.55657223
67CAMK2D0.54480523
68DYRK20.53884824
69PRKACA0.53683586
70MKNK10.53535444
71CDK80.51668047
72PRKCQ0.50002883
73DYRK30.48398551
74STK30.48351055
75SYK0.44072877
76PKN10.43027231
77GRK50.42860357
78CDK30.42236603
79PRKCI0.42144280
80CDK140.41733093
81PRKCA0.41215227
82PRKG20.40146659
83PASK0.40103914
84TRPM70.40025938
85KIT0.38336860
86CDK180.37994031
87PAK30.36260747
88PRKG10.36145878
89CDK150.35658437
90RPS6KA50.35453531
91FES0.34809403
92NTRK20.34161312
93EPHB20.34077386
94CDK11A0.33820332
95TNK20.33816537
96PRKCZ0.33681303
97STK40.33660474
98CSNK1A1L0.32446507
99GRK60.31969797
100EIF2AK30.31523500

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.42145070
2Linoleic acid metabolism_Homo sapiens_hsa005913.33492842
3Oxidative phosphorylation_Homo sapiens_hsa001902.85811347
4Protein export_Homo sapiens_hsa030602.85455333
5Ether lipid metabolism_Homo sapiens_hsa005652.78489019
6Parkinsons disease_Homo sapiens_hsa050122.59678240
7RNA polymerase_Homo sapiens_hsa030202.52334230
8Caffeine metabolism_Homo sapiens_hsa002322.50055646
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.33667550
10Nicotine addiction_Homo sapiens_hsa050332.18656612
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18528122
12Vitamin B6 metabolism_Homo sapiens_hsa007502.09728257
13Sulfur relay system_Homo sapiens_hsa041222.04918082
14Nitrogen metabolism_Homo sapiens_hsa009102.01965164
15Proteasome_Homo sapiens_hsa030501.97930769
16Propanoate metabolism_Homo sapiens_hsa006401.84092965
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82838747
18Asthma_Homo sapiens_hsa053101.80132511
19Phototransduction_Homo sapiens_hsa047441.79037251
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79000988
21Ribosome_Homo sapiens_hsa030101.67599641
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64492090
23Autoimmune thyroid disease_Homo sapiens_hsa053201.64231219
24Allograft rejection_Homo sapiens_hsa053301.63830459
25Alzheimers disease_Homo sapiens_hsa050101.62178692
26Arachidonic acid metabolism_Homo sapiens_hsa005901.60920442
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54656822
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52246548
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.49866746
30Huntingtons disease_Homo sapiens_hsa050161.46312875
31One carbon pool by folate_Homo sapiens_hsa006701.37115824
32Fatty acid biosynthesis_Homo sapiens_hsa000611.33881147
33Cardiac muscle contraction_Homo sapiens_hsa042601.33675634
34RNA degradation_Homo sapiens_hsa030181.32914436
35Fat digestion and absorption_Homo sapiens_hsa049751.32439024
36Butanoate metabolism_Homo sapiens_hsa006501.29980378
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.28776350
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23491766
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21481737
40Basal transcription factors_Homo sapiens_hsa030221.13591601
41Homologous recombination_Homo sapiens_hsa034401.02342501
42Ovarian steroidogenesis_Homo sapiens_hsa049131.00783358
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99032318
44Sulfur metabolism_Homo sapiens_hsa009200.97317867
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96473514
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95524365
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94952061
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.94067468
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91217036
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89350536
51Primary immunodeficiency_Homo sapiens_hsa053400.88217040
52Pyrimidine metabolism_Homo sapiens_hsa002400.84678114
53Type I diabetes mellitus_Homo sapiens_hsa049400.81928702
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81273091
55Folate biosynthesis_Homo sapiens_hsa007900.79253934
56Taste transduction_Homo sapiens_hsa047420.77272866
57Insulin secretion_Homo sapiens_hsa049110.76274317
58Selenocompound metabolism_Homo sapiens_hsa004500.75514394
59Chemical carcinogenesis_Homo sapiens_hsa052040.73832986
60Tryptophan metabolism_Homo sapiens_hsa003800.73128517
61Serotonergic synapse_Homo sapiens_hsa047260.72864695
62Peroxisome_Homo sapiens_hsa041460.71177449
63Steroid biosynthesis_Homo sapiens_hsa001000.69023415
64Metabolic pathways_Homo sapiens_hsa011000.66831951
65Purine metabolism_Homo sapiens_hsa002300.65843892
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65441090
67Collecting duct acid secretion_Homo sapiens_hsa049660.64690298
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62448594
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.58163424
70Retinol metabolism_Homo sapiens_hsa008300.57753023
71Pyruvate metabolism_Homo sapiens_hsa006200.57312695
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56493524
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.55320767
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54701920
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54054991
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50571192
77Rheumatoid arthritis_Homo sapiens_hsa053230.47453982
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46862113
79Mineral absorption_Homo sapiens_hsa049780.45598198
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44436811
81Graft-versus-host disease_Homo sapiens_hsa053320.44280938
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.44040718
83Glutamatergic synapse_Homo sapiens_hsa047240.43625616
84Cocaine addiction_Homo sapiens_hsa050300.43018567
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41240339
86Synaptic vesicle cycle_Homo sapiens_hsa047210.40880021
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.40096848
88Type II diabetes mellitus_Homo sapiens_hsa049300.40049799
89Pancreatic secretion_Homo sapiens_hsa049720.37586017
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.36723039
91Tyrosine metabolism_Homo sapiens_hsa003500.35867899
92Starch and sucrose metabolism_Homo sapiens_hsa005000.35791875
93Glycerolipid metabolism_Homo sapiens_hsa005610.33392963
94Nucleotide excision repair_Homo sapiens_hsa034200.30741969
95Olfactory transduction_Homo sapiens_hsa047400.30436288
96Fanconi anemia pathway_Homo sapiens_hsa034600.28850047
97Glutathione metabolism_Homo sapiens_hsa004800.28808864
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27813162
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25751933
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25607091

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