SPCS2P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.19028624
2signal peptide processing (GO:0006465)4.81656125
3proteasome assembly (GO:0043248)4.53984214
4respiratory chain complex IV assembly (GO:0008535)4.32269038
5water-soluble vitamin biosynthetic process (GO:0042364)4.12551914
6cytochrome complex assembly (GO:0017004)3.93815751
7regulation of cellular amino acid metabolic process (GO:0006521)3.91417305
8cytidine deamination (GO:0009972)3.90517515
9cytidine metabolic process (GO:0046087)3.90517515
10cytidine catabolic process (GO:0006216)3.90517515
11DNA double-strand break processing (GO:0000729)3.76160877
12lactate metabolic process (GO:0006089)3.71832148
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.70186422
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.70123050
15signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.63796017
16signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.63796017
17signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.63796017
18cullin deneddylation (GO:0010388)3.61648848
19positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.59448847
20intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.58386249
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.58386249
22protein complex biogenesis (GO:0070271)3.53328335
23somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.50457200
24somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.50457200
25isotype switching (GO:0045190)3.50457200
26mannosylation (GO:0097502)3.49445279
27protein deneddylation (GO:0000338)3.48220364
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.47270786
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.45303168
30signal transduction involved in DNA integrity checkpoint (GO:0072401)3.44767869
31signal transduction involved in DNA damage checkpoint (GO:0072422)3.44767869
32signal transduction involved in cell cycle checkpoint (GO:0072395)3.43634733
33rRNA modification (GO:0000154)3.43241841
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37244089
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.34274290
36negative regulation of ligase activity (GO:0051352)3.34274290
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31967968
38maturation of 5.8S rRNA (GO:0000460)3.30503299
39pyrimidine ribonucleoside catabolic process (GO:0046133)3.28268871
40mitochondrial respiratory chain complex assembly (GO:0033108)3.28147869
41fucose catabolic process (GO:0019317)3.26129474
42L-fucose metabolic process (GO:0042354)3.26129474
43L-fucose catabolic process (GO:0042355)3.26129474
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.23668297
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.23064482
46platelet dense granule organization (GO:0060155)3.22000034
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18162312
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18162312
49pseudouridine synthesis (GO:0001522)3.17721785
50energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16626859
51ATP synthesis coupled proton transport (GO:0015986)3.16626859
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.11746864
53branched-chain amino acid catabolic process (GO:0009083)3.09204508
54preassembly of GPI anchor in ER membrane (GO:0016254)3.08559859
55DNA catabolic process, exonucleolytic (GO:0000738)3.07218168
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06106210
57protein-cofactor linkage (GO:0018065)3.05819128
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04984556
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01928905
60transcription elongation from RNA polymerase III promoter (GO:0006385)3.00807091
61termination of RNA polymerase III transcription (GO:0006386)3.00807091
62positive regulation of ligase activity (GO:0051351)2.97683758
63protein neddylation (GO:0045116)2.95395920
64antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.91273371
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.88549303
66mitochondrial respiratory chain complex I assembly (GO:0032981)2.88549303
67NADH dehydrogenase complex assembly (GO:0010257)2.88549303
68rRNA methylation (GO:0031167)2.84730718
69DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.84245945
70negative regulation of DNA-dependent DNA replication (GO:2000104)2.81804838
71regulation of cellular amine metabolic process (GO:0033238)2.81174812
72electron transport chain (GO:0022900)2.80324255
73respiratory electron transport chain (GO:0022904)2.80194097
74positive regulation of cell cycle arrest (GO:0071158)2.75639514
75RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.75122128
76regulation of mitochondrial translation (GO:0070129)2.72111136
77adenosine metabolic process (GO:0046085)2.71330617
78antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.66257219
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65981538
80regulation of mitotic spindle checkpoint (GO:1903504)2.63859303
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.63859303
82C-terminal protein lipidation (GO:0006501)2.60083441
83regulation of ubiquitin-protein transferase activity (GO:0051438)2.56737992
84regulation of hexokinase activity (GO:1903299)2.55304232
85regulation of glucokinase activity (GO:0033131)2.55304232
86somatic diversification of immunoglobulins (GO:0016445)2.54998543
87cellular ketone body metabolic process (GO:0046950)2.53793820
88regulation of ligase activity (GO:0051340)2.52783415
89tRNA processing (GO:0008033)2.52672797
90negative regulation of telomere maintenance (GO:0032205)2.51918141
91S-adenosylmethionine metabolic process (GO:0046500)2.48868118
92dopamine transport (GO:0015872)2.48196737
93branched-chain amino acid metabolic process (GO:0009081)2.47245216
94histone H2A acetylation (GO:0043968)2.46727081
95nucleobase biosynthetic process (GO:0046112)2.46540704
96ubiquinone biosynthetic process (GO:0006744)2.45978429
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.45016556
98negative regulation of thymocyte apoptotic process (GO:0070244)2.44846692
99GPI anchor biosynthetic process (GO:0006506)2.44632438
100replication fork processing (GO:0031297)2.44327791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.89373495
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.10140334
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.63467465
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.56329795
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23132642
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.10570189
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92526981
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91076500
9VDR_23849224_ChIP-Seq_CD4+_Human2.72441210
10ZNF274_21170338_ChIP-Seq_K562_Hela2.63781125
11ELK1_19687146_ChIP-ChIP_HELA_Human2.55204706
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.46848438
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.38992056
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38714161
15VDR_22108803_ChIP-Seq_LS180_Human2.33560652
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.32620991
17FOXP3_21729870_ChIP-Seq_TREG_Human2.24066995
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16671614
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08967014
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07640321
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97388488
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.96643410
23IGF1R_20145208_ChIP-Seq_DFB_Human1.96325196
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.96039658
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93729447
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.89856655
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85895947
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84703846
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81512338
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80166117
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70705276
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70673998
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65889982
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59350256
35MYC_18940864_ChIP-ChIP_HL60_Human1.56089693
36DCP1A_22483619_ChIP-Seq_HELA_Human1.55208879
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53821809
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52410644
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.47280431
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46333786
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46256943
42EWS_26573619_Chip-Seq_HEK293_Human1.40986211
43E2F7_22180533_ChIP-Seq_HELA_Human1.40168690
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37682346
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37154879
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36905668
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33013965
48TP53_22573176_ChIP-Seq_HFKS_Human1.32466483
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32053993
50GABP_19822575_ChIP-Seq_HepG2_Human1.30325023
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.25236593
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24866719
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.23719694
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23719694
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23001087
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22818205
57AR_20517297_ChIP-Seq_VCAP_Human1.21660103
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20107289
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19706374
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18994664
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16816709
62GATA3_26560356_Chip-Seq_TH2_Human1.14489851
63HTT_18923047_ChIP-ChIP_STHdh_Human1.13779467
64P300_19829295_ChIP-Seq_ESCs_Human1.12482272
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11953203
66TAF15_26573619_Chip-Seq_HEK293_Human1.11022476
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.10728450
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10277143
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.09860316
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08771019
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.08001754
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07263811
73FUS_26573619_Chip-Seq_HEK293_Human1.06713876
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06481583
75NANOG_19829295_ChIP-Seq_ESCs_Human1.06205602
76SOX2_19829295_ChIP-Seq_ESCs_Human1.06205602
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05571067
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.03066698
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00729771
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00077269
81ER_23166858_ChIP-Seq_MCF-7_Human0.99122844
82TTF2_22483619_ChIP-Seq_HELA_Human0.96933828
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96587264
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.95820477
85CRX_20693478_ChIP-Seq_RETINA_Mouse0.94566558
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93226801
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91873982
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91580101
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91488124
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91430447
91RBPJ_21746931_ChIP-Seq_IB4_Human0.90975643
92BCAT_22108803_ChIP-Seq_LS180_Human0.90733858
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90616110
94CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89764270
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88829223
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88598751
97CDX2_22108803_ChIP-Seq_LS180_Human0.87647367
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87314987
99NCOR_22424771_ChIP-Seq_293T_Human0.86803712
100EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.84339140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.35845065
2MP0005671_abnormal_response_to3.07254584
3MP0002837_dystrophic_cardiac_calcinosis2.89791341
4MP0003806_abnormal_nucleotide_metabolis2.79269749
5MP0008877_abnormal_DNA_methylation2.74371721
6MP0006072_abnormal_retinal_apoptosis2.71308309
7MP0001835_abnormal_antigen_presentation2.54655374
8MP0008058_abnormal_DNA_repair2.45625066
9MP0002102_abnormal_ear_morphology2.34783631
10MP0005084_abnormal_gallbladder_morpholo2.30462564
11MP0003787_abnormal_imprinting2.25715683
12MP0003786_premature_aging2.23499830
13MP0002163_abnormal_gland_morphology2.18659618
14MP0009785_altered_susceptibility_to2.17207475
15MP0006036_abnormal_mitochondrial_physio2.05407266
16MP0005645_abnormal_hypothalamus_physiol1.96218949
17MP0002138_abnormal_hepatobiliary_system1.96013312
18MP0010094_abnormal_chromosome_stability1.90710792
19MP0008872_abnormal_physiological_respon1.87490662
20MP0005379_endocrine/exocrine_gland_phen1.83812409
21MP0002876_abnormal_thyroid_physiology1.74947457
22MP0002254_reproductive_system_inflammat1.73523017
23MP0002148_abnormal_hypersensitivity_rea1.71257915
24MP0002166_altered_tumor_susceptibility1.67898839
25MP0000685_abnormal_immune_system1.66309120
26MP0005075_abnormal_melanosome_morpholog1.65588507
27MP0008875_abnormal_xenobiotic_pharmacok1.62965901
28MP0006035_abnormal_mitochondrial_morpho1.62965715
29MP0009697_abnormal_copulation1.61319132
30MP0002693_abnormal_pancreas_physiology1.58842837
31MP0000372_irregular_coat_pigmentation1.57813468
32MP0009333_abnormal_splenocyte_physiolog1.56967593
33MP0001873_stomach_inflammation1.53181282
34MP0003186_abnormal_redox_activity1.49710642
35MP0005387_immune_system_phenotype1.47278516
36MP0001790_abnormal_immune_system1.47278516
37MP0005253_abnormal_eye_physiology1.42591942
38MP0005000_abnormal_immune_tolerance1.40112407
39MP0002006_tumorigenesis1.38452385
40MP0008007_abnormal_cellular_replicative1.36730590
41MP0001800_abnormal_humoral_immune1.34549381
42MP0003011_delayed_dark_adaptation1.33440859
43MP0005551_abnormal_eye_electrophysiolog1.32790814
44MP0003718_maternal_effect1.31367295
45MP0000516_abnormal_urinary_system1.30459120
46MP0005367_renal/urinary_system_phenotyp1.30459120
47MP0002139_abnormal_hepatobiliary_system1.26696173
48MP0006082_CNS_inflammation1.24505070
49MP0002736_abnormal_nociception_after1.22500524
50MP0005332_abnormal_amino_acid1.19314777
51MP0004147_increased_porphyrin_level1.18337990
52MP0002723_abnormal_immune_serum1.16800341
53MP0003121_genomic_imprinting1.16324360
54MP0003763_abnormal_thymus_physiology1.15623081
55MP0006054_spinal_hemorrhage1.13211972
56MP0001968_abnormal_touch/_nociception1.12397636
57MP0001845_abnormal_inflammatory_respons1.11138549
58MP0003693_abnormal_embryo_hatching1.09923920
59MP0005220_abnormal_exocrine_pancreas1.07996451
60MP0002420_abnormal_adaptive_immunity1.06706888
61MP0003866_abnormal_defecation1.06580111
62MP0005636_abnormal_mineral_homeostasis1.06377615
63MP0002452_abnormal_antigen_presenting1.06148602
64MP0001819_abnormal_immune_cell1.04913145
65MP0002277_abnormal_respiratory_mucosa1.04091615
66MP0000427_abnormal_hair_cycle1.03767556
67MP0001764_abnormal_homeostasis1.03382891
68MP0010155_abnormal_intestine_physiology1.02459188
69MP0001984_abnormal_olfaction1.01358009
70MP0004957_abnormal_blastocyst_morpholog1.01227817
71MP0009046_muscle_twitch1.00561246
72MP0000689_abnormal_spleen_morphology0.97712489
73MP0003252_abnormal_bile_duct0.97418706
74MP0001944_abnormal_pancreas_morphology0.95038890
75MP0002751_abnormal_autonomic_nervous0.94344892
76MP0004215_abnormal_myocardial_fiber0.91872489
77MP0001919_abnormal_reproductive_system0.90458842
78MP0009764_decreased_sensitivity_to0.90242877
79MP0001986_abnormal_taste_sensitivity0.89047208
80MP0001661_extended_life_span0.88000318
81MP0005389_reproductive_system_phenotype0.87805907
82MP0005025_abnormal_response_to0.81743261
83MP0001905_abnormal_dopamine_level0.80909675
84MP0008469_abnormal_protein_level0.79785025
85MP0008873_increased_physiological_sensi0.78995991
86MP0005365_abnormal_bile_salt0.78603823
87MP0000716_abnormal_immune_system0.77800481
88MP0003880_abnormal_central_pattern0.77188924
89MP0004043_abnormal_pH_regulation0.77104457
90MP0003111_abnormal_nucleus_morphology0.76250786
91MP0005410_abnormal_fertilization0.75699879
92MP0002398_abnormal_bone_marrow0.75084655
93MP0005319_abnormal_enzyme/_coenzyme0.75058282
94MP0002928_abnormal_bile_duct0.73689688
95MP0008775_abnormal_heart_ventricle0.73345292
96MP0001529_abnormal_vocalization0.73000080
97MP0002090_abnormal_vision0.71546478
98MP0000358_abnormal_cell_content/0.70771460
99MP0001501_abnormal_sleep_pattern0.69734646
100MP0002722_abnormal_immune_system0.67683242

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.16917406
2Progressive macrocephaly (HP:0004481)3.86109367
3Mitochondrial inheritance (HP:0001427)3.76290319
4Increased CSF lactate (HP:0002490)3.72691592
5Acute encephalopathy (HP:0006846)3.71037560
6Abnormal mitochondria in muscle tissue (HP:0008316)3.66701269
7Increased hepatocellular lipid droplets (HP:0006565)3.37141936
8Hepatic necrosis (HP:0002605)3.33673601
9Hypothermia (HP:0002045)3.26040745
10Hepatocellular necrosis (HP:0001404)3.24820741
11Lipid accumulation in hepatocytes (HP:0006561)3.23790669
12Methylmalonic acidemia (HP:0002912)3.16880428
13Stomatitis (HP:0010280)2.87849969
14Methylmalonic aciduria (HP:0012120)2.85402803
15Ketoacidosis (HP:0001993)2.83142155
16Decreased activity of mitochondrial respiratory chain (HP:0008972)2.82236465
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.82236465
18Cerebral edema (HP:0002181)2.80676074
19Renal Fanconi syndrome (HP:0001994)2.80472701
203-Methylglutaconic aciduria (HP:0003535)2.76239832
21Congenital, generalized hypertrichosis (HP:0004540)2.75687685
22Renal cortical cysts (HP:0000803)2.67635006
23Increased serum lactate (HP:0002151)2.63838756
24Pancreatic cysts (HP:0001737)2.60323710
25Hypoglycemic coma (HP:0001325)2.59617334
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54605805
27Thyroiditis (HP:0100646)2.52874843
28Lactic acidosis (HP:0003128)2.51279750
29Hypoproteinemia (HP:0003075)2.46199777
30Abnormality of the renal cortex (HP:0011035)2.45379974
31Hyperinsulinemic hypoglycemia (HP:0000825)2.42008996
32Abnormality of vitamin B metabolism (HP:0004340)2.41766189
33IgG deficiency (HP:0004315)2.40887216
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35199712
35Hypoglycemic seizures (HP:0002173)2.34852993
36Glycosuria (HP:0003076)2.32651531
37Abnormality of urine glucose concentration (HP:0011016)2.32651531
38Hyperglycemia (HP:0003074)2.32650334
39Degeneration of anterior horn cells (HP:0002398)2.32615787
40Abnormality of the anterior horn cell (HP:0006802)2.32615787
41Lethargy (HP:0001254)2.31812584
42Respiratory failure (HP:0002878)2.31682663
43Congenital stationary night blindness (HP:0007642)2.31649749
44Abnormality of midbrain morphology (HP:0002418)2.30586392
45Molar tooth sign on MRI (HP:0002419)2.30586392
46Abnormality of endocrine pancreas physiology (HP:0012093)2.27719342
47Abnormality of the pancreatic islet cells (HP:0006476)2.27719342
48Generalized aminoaciduria (HP:0002909)2.26291992
49Tongue fasciculations (HP:0001308)2.25896209
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25224323
51Pancreatic fibrosis (HP:0100732)2.24292786
52Increased intramyocellular lipid droplets (HP:0012240)2.23588628
53Ketosis (HP:0001946)2.23026285
54Aplastic anemia (HP:0001915)2.21812497
55Exertional dyspnea (HP:0002875)2.21382080
56Severe combined immunodeficiency (HP:0004430)2.19194503
57Optic disc pallor (HP:0000543)2.18964147
58Type I transferrin isoform profile (HP:0003642)2.17996945
59True hermaphroditism (HP:0010459)2.15222050
60Abnormality of methionine metabolism (HP:0010901)2.13245961
61Abnormality of the labia minora (HP:0012880)2.12306266
62Abnormality of the vitamin B12 metabolism (HP:0004341)2.11860760
63Aplasia/hypoplasia of the uterus (HP:0008684)2.09870996
64Abolished electroretinogram (ERG) (HP:0000550)2.09755413
65Hypomagnesemia (HP:0002917)2.07040894
66Abnormal protein N-linked glycosylation (HP:0012347)2.06501611
67Abnormal protein glycosylation (HP:0012346)2.06501611
68Abnormal glycosylation (HP:0012345)2.06501611
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06501611
70Neoplasm of the adrenal gland (HP:0100631)2.04060345
71Progressive microcephaly (HP:0000253)2.01325129
72Dicarboxylic aciduria (HP:0003215)2.01269578
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01269578
74Pancreatic islet-cell hyperplasia (HP:0004510)1.99868989
75Progressive inability to walk (HP:0002505)1.98308909
76Leukodystrophy (HP:0002415)1.96710667
77Palpitations (HP:0001962)1.96522677
78Pancytopenia (HP:0001876)1.95550506
79Exercise intolerance (HP:0003546)1.94177646
80Abnormality of T cell physiology (HP:0011840)1.94025877
81Abnormality of B cell number (HP:0010975)1.93357681
82Abnormality of the prostate (HP:0008775)1.93106216
83Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91797413
84Symptomatic seizures (HP:0011145)1.88924959
85Abnormal drinking behavior (HP:0030082)1.87841863
86Polydipsia (HP:0001959)1.87841863
87Hyperglycinuria (HP:0003108)1.87553722
88Prominent metopic ridge (HP:0005487)1.86970597
89Increased muscle lipid content (HP:0009058)1.84595288
90B lymphocytopenia (HP:0010976)1.84303061
91Muscle fibrillation (HP:0010546)1.83375843
92Abnormality of serine family amino acid metabolism (HP:0010894)1.79073343
93Abnormality of glycine metabolism (HP:0010895)1.79073343
94Bile duct proliferation (HP:0001408)1.79038733
95Abnormal biliary tract physiology (HP:0012439)1.79038733
96Conjunctival hamartoma (HP:0100780)1.78104817
97Large for gestational age (HP:0001520)1.77492375
98Nephronophthisis (HP:0000090)1.77404783
99Hypoalbuminemia (HP:0003073)1.76633780
100Abnormal albumin level (HP:0012116)1.76633780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.79728476
2MST43.04440097
3VRK22.84865765
4EIF2AK32.71188959
5NUAK12.70229931
6ZAK2.66583778
7TXK2.56837826
8TSSK62.52880530
9MAP4K22.32276147
10BMPR1B2.21510172
11TRIM282.19806025
12WNK32.01631601
13STK161.98748312
14BUB11.96291699
15VRK11.89079339
16MAP3K121.88098045
17GRK11.87044918
18EIF2AK11.83698777
19PLK31.76886435
20ADRBK21.74907143
21ACVR1B1.74520408
22TNIK1.71838404
23TLK11.65689830
24NEK11.62942196
25BCKDK1.59824113
26MKNK21.43725818
27SRPK11.33451518
28PLK21.24250495
29OXSR11.22167120
30BCR1.21605593
31CSNK1G31.19990489
32ERBB31.17247803
33MAP2K61.14739854
34INSRR1.14648634
35TAOK31.12708150
36CSNK1G11.12560316
37PHKG21.09972566
38PHKG11.09972566
39DAPK11.06691096
40WNK41.04568980
41CSNK1G21.02589408
42KDR0.96196408
43MKNK10.91163186
44BRSK20.88265621
45STK390.87474625
46TAF10.87388312
47MAP4K10.85404208
48PLK40.84376760
49IKBKB0.83295785
50MAPKAPK30.82502275
51FER0.81524986
52TEC0.79471677
53TIE10.77070871
54EIF2AK20.76897905
55CSNK1A1L0.75633869
56MYLK0.74656958
57TTK0.70342613
58PRKCE0.70175768
59STK38L0.70067437
60PASK0.68662151
61SIK30.67282815
62FGFR20.66648196
63LIMK10.66485690
64NME10.66117700
65PBK0.65181679
66NLK0.63512066
67WEE10.63043226
68PAK30.61440944
69KIT0.61186185
70BMPR20.60968887
71ITK0.60208014
72PINK10.59464639
73MAPK130.59117917
74PLK10.55186531
75CDC70.54959006
76STK30.54703657
77EPHA30.53125367
78ATR0.51622857
79PRKCQ0.50885237
80TESK10.47302477
81IKBKE0.44400183
82PRKCI0.44301390
83FLT30.43094265
84MAP3K140.41863018
85SCYL20.41740243
86MAPKAPK50.39461116
87ALK0.39187499
88LYN0.38867882
89IRAK10.38751353
90RPS6KA50.37560698
91FES0.36859324
92ATM0.36357088
93CAMKK20.36352976
94CSNK1A10.35906289
95PTK2B0.35739990
96PRKCG0.35512669
97CSNK2A10.35480822
98SYK0.35232036
99CLK10.34932861
100PAK40.34139437

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.58494447
2Protein export_Homo sapiens_hsa030604.24030303
3Oxidative phosphorylation_Homo sapiens_hsa001902.75063702
4Parkinsons disease_Homo sapiens_hsa050122.20493553
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.14410886
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10251685
7Type I diabetes mellitus_Homo sapiens_hsa049402.08925621
8RNA polymerase_Homo sapiens_hsa030202.08500211
9Non-homologous end-joining_Homo sapiens_hsa034502.07839681
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02988235
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87606277
12Fatty acid elongation_Homo sapiens_hsa000621.86126634
13Allograft rejection_Homo sapiens_hsa053301.85626446
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81582580
15Propanoate metabolism_Homo sapiens_hsa006401.80560819
16Homologous recombination_Homo sapiens_hsa034401.73703168
17Autoimmune thyroid disease_Homo sapiens_hsa053201.73351331
18Mismatch repair_Homo sapiens_hsa034301.70164417
19Sulfur metabolism_Homo sapiens_hsa009201.66942533
20Primary immunodeficiency_Homo sapiens_hsa053401.64298887
21Asthma_Homo sapiens_hsa053101.58428537
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.57174679
23One carbon pool by folate_Homo sapiens_hsa006701.54739838
24Graft-versus-host disease_Homo sapiens_hsa053321.52862104
25Butanoate metabolism_Homo sapiens_hsa006501.51184245
26Basal transcription factors_Homo sapiens_hsa030221.45284119
27RNA degradation_Homo sapiens_hsa030181.44458531
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43797077
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43781901
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37410886
31Collecting duct acid secretion_Homo sapiens_hsa049661.34227678
32DNA replication_Homo sapiens_hsa030301.33263449
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32551991
34Phototransduction_Homo sapiens_hsa047441.31315556
35Rheumatoid arthritis_Homo sapiens_hsa053231.24815153
36Alzheimers disease_Homo sapiens_hsa050101.23177737
37Antigen processing and presentation_Homo sapiens_hsa046121.22193587
38Huntingtons disease_Homo sapiens_hsa050161.21427544
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18583563
40Fanconi anemia pathway_Homo sapiens_hsa034601.18135672
41Pyrimidine metabolism_Homo sapiens_hsa002401.15476999
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14405293
43Tryptophan metabolism_Homo sapiens_hsa003801.13114071
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10565540
45Caffeine metabolism_Homo sapiens_hsa002321.09852598
46Selenocompound metabolism_Homo sapiens_hsa004501.06044965
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03832687
48Peroxisome_Homo sapiens_hsa041461.03430841
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.01021781
50Base excision repair_Homo sapiens_hsa034101.01021144
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99564226
52Vitamin B6 metabolism_Homo sapiens_hsa007500.99089152
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95676531
54Folate biosynthesis_Homo sapiens_hsa007900.94053201
55Purine metabolism_Homo sapiens_hsa002300.93725076
56RNA transport_Homo sapiens_hsa030130.93115948
57Nucleotide excision repair_Homo sapiens_hsa034200.89324345
58Steroid biosynthesis_Homo sapiens_hsa001000.86321010
59Spliceosome_Homo sapiens_hsa030400.83779253
60Pyruvate metabolism_Homo sapiens_hsa006200.83709334
61Glutathione metabolism_Homo sapiens_hsa004800.83624226
62Regulation of autophagy_Homo sapiens_hsa041400.79807374
63Nitrogen metabolism_Homo sapiens_hsa009100.79039893
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75655632
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71589576
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71507649
67Linoleic acid metabolism_Homo sapiens_hsa005910.71415890
68Metabolic pathways_Homo sapiens_hsa011000.67167179
69Ether lipid metabolism_Homo sapiens_hsa005650.64888279
70Fatty acid metabolism_Homo sapiens_hsa012120.64296321
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.61366027
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61260421
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60946895
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60496171
75Systemic lupus erythematosus_Homo sapiens_hsa053220.60395858
76Hematopoietic cell lineage_Homo sapiens_hsa046400.58362377
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55947313
78Legionellosis_Homo sapiens_hsa051340.54871873
79Fatty acid degradation_Homo sapiens_hsa000710.53712550
80beta-Alanine metabolism_Homo sapiens_hsa004100.53601162
81Chemical carcinogenesis_Homo sapiens_hsa052040.49864290
82Arachidonic acid metabolism_Homo sapiens_hsa005900.48712839
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48289090
84N-Glycan biosynthesis_Homo sapiens_hsa005100.47960868
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44650853
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.44092075
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43555420
88Retinol metabolism_Homo sapiens_hsa008300.41823363
89Vibrio cholerae infection_Homo sapiens_hsa051100.41313736
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41292751
91Carbon metabolism_Homo sapiens_hsa012000.39704924
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38257455
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37680852
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.37270531
95Viral myocarditis_Homo sapiens_hsa054160.35618583
96Herpes simplex infection_Homo sapiens_hsa051680.35321949
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34738916
98Cardiac muscle contraction_Homo sapiens_hsa042600.34396351
99Epstein-Barr virus infection_Homo sapiens_hsa051690.34348001
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.34338460

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